TY  - GEN
A1  - Stuetz, Wolfgang
A1  - Weber, Daniela
A1  - Dollé, Martijn E. T.
A1  - Jansen, Eugène
A1  - Grubeck-Loebenstein, Beatrix
A1  - Fiegl, Simone
A1  - Toussaint, Olivier
A1  - Bernhardt, Juergen
A1  - Gonos, Efstathios S.
A1  - Franceschi, Claudio
A1  - Sikora, Ewa
A1  - Moreno-Villanueva, María
A1  - Breusing, Nicolle
A1  - Grune, Tilman
A1  - Bürkle, Alexander
T1  - Plasma carotenoids, tocopherols, and retinol in the age-stratified (35–74 years) general population
BT  - a cross-sectional study in six European countries
T2  - Nutrients
N2  - Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels. Significant correlations with age were observed for lycopene (r = −0.248), α-tocopherol (r = 0.208), α-carotene (r = −0.112), and β-cryptoxanthin (r = 0.125; all p < 0.001). Age was inversely associated with lycopene (−6.5% per five-year age increase) and this association remained in the multiple regression model with the significant predictors (covariables) being country, season, cholesterol, gender, smoking status, body mass index (BMI (kg/m2)), and dietary habits. The positive association of α-tocopherol with age remained when all covariates including cholesterol and use of vitamin supplements were included (1.7% vs. 2.4% per five-year age increase). The association of higher β-cryptoxanthin with higher age was no longer statistically significant after adjustment for fruit consumption, whereas the inverse association of α-carotene with age remained in the fully adjusted multivariable model (−4.8% vs. −3.8% per five-year age increase). We conclude from our study that age is an independent predictor of plasma lycopene, α-tocopherol, and α-carotene.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 449 
KW  - carotenoids
KW  - plasma
KW  - age
KW  - Europe
KW  - micronutrient
KW  - lycopene
KW  - retinol
KW  - tocopherols
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-407659
ER  - 
TY  - GEN
A1  - Henze, Andrea
A1  - Raila, Jens
A1  - Kempf, Caroline
A1  - Reinke, Petra
A1  - Sefrin, Anett
A1  - Querfeld, Uwe
A1  - Schweigert, Florian J.
T1  - Vitamin A metabolism is changed in donors after living-kidney transplantation
BT  - an observational study
N2  - Background

The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT.
Results

As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months.
Conclusion

LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 373 
KW  - Donors
KW  - glomerular filtration rate
KW  - kidney transplantation
KW  - retinol
KW  - retinol-binding protein 4
KW  - transthyretin
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-400942
ER  -