TY  - GEN
A1  - Taubert, Andreas
A1  - Balischewski, Christian
A1  - Hentrich, Doreen
A1  - Elschner, Thomas
A1  - Eidner, Sascha
A1  - Günter, Christina
A1  - Behrens, Karsten
A1  - Heinze, Thomas
T1  - Water-soluble cellulose derivatives are sustainable additives for biomimetic calcium phosphate mineralization
N2  - The effect of cellulose-based polyelectrolytes on biomimetic calcium phosphate mineralization is described. Three cellulose derivatives, a polyanion, a polycation, and a polyzwitterion were used as additives. Scanning electron microscopy, X-ray diffraction, IR and Raman spectroscopy show that, depending on the composition of the starting solution, hydroxyapatite or brushite precipitates form. Infrared and Raman spectroscopy also show that significant amounts of nitrate ions are incorporated in the precipitates. Energy dispersive X-ray spectroscopy shows that the Ca/P ratio varies throughout the samples and resembles that of other bioinspired calcium phosphate hybrid materials. Elemental analysis shows that the carbon (i.e., polymer) contents reach 10% in some samples, clearly illustrating the formation of a true hybrid material. Overall, the data indicate that a higher polymer concentration in the reaction mixture favors the formation of polymer-enriched materials, while lower polymer concentrations or high precursor concentrations favor the formation of products that are closely related to the control samples precipitated in the absence of polymer. The results thus highlight the potential of (water-soluble) cellulose derivatives for the synthesis and design of bioinspired and bio-based hybrid materials.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 354 
KW  - cellulose
KW  - polyamine
KW  - polyammonium salt
KW  - polycarboxylate
KW  - polyzwitterion
KW  - calcium phosphate
KW  - biomineralization
KW  - brushite
KW  - hydroyxapatite
KW  - biomaterial
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-400453
ER  - 
TY  - GEN
A1  - Hentrich, Doreen
A1  - Tauer, Klaus
A1  - Espanol, Montserrat
A1  - Ginebra, Maria-Pau
A1  - Taubert, Andreas
T1  - EDTA and NTA effectively tune the mineralization of calcium phosphate from bulk aqueous solution
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - This study describes the effects of nitrilotriacetic acid (NTA) and ethylenediaminotetraacetic acid (EDTA) on themineralization of calciumphosphate from bulk aqueous solution. Mineralization was performed between pH 6 and 9 and with NTA or EDTA concentrations of 0, 5, 10, and 15 mM. X-ray diffraction and infrared spectroscopy show that at low pH, mainly brushite precipitates and at higher pH, mostly hydroxyapatite forms. Both additives alter the morphology of the precipitates. Without additive, brushite precipitates as large plates. With NTA, the morphology changes to an unusual rod-like shape. With EDTA, the edges of the particles are rounded and disk-like particles form. Conductivity and pH measurements suggest that the final products form through several intermediate steps.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1095 
KW  - biomineralization
KW  - biomimetic mineralization
KW  - calcium phosphate
KW  - NTA
KW  - EDTA
KW  - precipitation
KW  - brushite
KW  - hydroxyapatite
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469186
SN  - 1866-8372
IS  - 1095
ER  - 
TY  - GEN
A1  - Hardy, John G.
A1  - Torres-Rendon, Jose Guillermo
A1  - Leal-Egaña, Aldo
A1  - Walther, Andreas
A1  - Schlaad, Helmut
A1  - Cölfen, Helmut
A1  - Scheibel, Thomas R.
T1  - Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering
N2  - Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 359 
KW  - spider silk
KW  - recombinant protein
KW  - biodegradable polymers
KW  - biomaterials
KW  - biomineralization
KW  - bone tissue engineering
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-400519
ER  -