TY  - JOUR
A1  - Göldel, Julia Marlen
A1  - Kamrath, Clemens
A1  - Minden, Kirsten
A1  - Wiegand, Susanna
A1  - Lanzinger, Stefanie
A1  - Sengler, Claudia
A1  - Weihrauch-Blüher, Susann
A1  - Holl, Reinhard
A1  - Tittel, Sascha René
A1  - Warschburger, Petra
T1  - Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany
JF  - Children
N2  - This study examines the access to healthcare for children and adolescents with three common chronic diseases (type-1 diabetes (T1D), obesity, or juvenile idiopathic arthritis (JIA)) within the 4th (Delta), 5th (Omicron), and beginning of the 6th (Omicron) wave (June 2021 until July 2022) of the COVID-19 pandemic in Germany in a cross-sectional study using three national patient registries. A paper-and-pencil questionnaire was given to parents of pediatric patients (<21 years) during the routine check-ups. The questionnaire contains self-constructed items assessing the frequency of healthcare appointments and cancellations, remote healthcare, and satisfaction with healthcare. In total, 905 parents participated in the T1D-sample, 175 in the obesity-sample, and 786 in the JIA-sample. In general, satisfaction with healthcare (scale: 0–10; 10 reflecting the highest satisfaction) was quite high (median values: T1D 10, JIA 10, obesity 8.5). The proportion of children and adolescents with canceled appointments was relatively small (T1D 14.1%, JIA 11.1%, obesity 20%), with a median of 1 missed appointment, respectively. Only a few parents (T1D 8.6%; obesity 13.1%; JIA 5%) reported obstacles regarding health services during the pandemic. To conclude, it seems that access to healthcare was largely preserved for children and adolescents with chronic health conditions during the COVID-19 pandemic in Germany.
KW  - chronic health condition
KW  - children and adolescents
KW  - health care
KW  - COVID-19 pandemic
KW  - diabetes
KW  - rheumatic diseases
KW  - obesity
Y1  - 2022
U6  - https://doi.org/10.3390/children10010010
SN  - 2227-9067
VL  - 10
SP  - 1
EP  - 11
PB  - MDPI
CY  - Basel, Schweiz
ET  - 1
ER  - 
TY  - JOUR
A1  - Delfan, Maryam
A1  - Juybari, Raheleh Amadeh
A1  - Gorgani-Firuzjaee, Sattar
A1  - Nielsen, Jens Høiriis
A1  - Delfan, Neda
A1  - Laher, Ismail
A1  - Saeidi, Ayoub
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats
JF  - Frontiers in Cardiovascular Medicine
N2  - Objective: A role for microRNAs is implicated in several biological and pathological processes. We investigated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on molecular markers of diabetic cardiomyopathy in rats.

Methods: Eighteen male Wistar rats (260 ± 10 g; aged 8 weeks) with streptozotocin (STZ)-induced type 1 diabetes mellitus (55 mg/kg, IP) were randomly allocated to three groups: control, MICT, and HIIT. The two different training protocols were performed 5 days each week for 5 weeks. Cardiac performance (end-systolic and end-diastolic dimensions, ejection fraction), the expression of miR-206, HSP60, and markers of apoptosis (cleaved PARP and cytochrome C) were determined at the end of the exercise interventions.

Results: Both exercise interventions (HIIT and MICT) decreased blood glucose levels and improved cardiac performance, with greater changes in the HIIT group (p < 0.001, η2: 0.909). While the expressions of miR-206 and apoptotic markers decreased in both training protocols (p < 0.001, η2: 0.967), HIIT caused greater reductions in apoptotic markers and produced a 20% greater reduction in miR-206 compared with the MICT protocol (p < 0.001). Furthermore, both training protocols enhanced the expression of HSP60 (p < 0.001, η2: 0.976), with a nearly 50% greater increase in the HIIT group compared with MICT.

Conclusions: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis. It seems however that HIIT is even more effective than MICT to modulate these molecular markers.
KW  - diabetes
KW  - apoptosis
KW  - miRNAs
KW  - exercise
KW  - cardiomyopathy
Y1  - 2022
U6  - https://doi.org/10.3389/fcvm.2022.927956
SN  - 2297-055X
VL  - 9
SP  - 1
EP  - 11
PB  - Frontiers
CY  - Lausanne, Schweiz
ER  -