TY  - JOUR
A1  - Dey, Pradip
A1  - Bergmann, Tobias
A1  - Cuellar-Camacho, Jose Luis
A1  - Ehrmann, Svenja
A1  - Chowdhury, Mohammad Suman
A1  - Zhang, Minze
A1  - Dahmani, Ismail
A1  - Haag, Rainer
A1  - Azad, Walid
T1  - Multivalent flexible nanogels exhibit broad-spectrum antiviral activity by blocking virus entry
JF  - ACS nano
N2  - The entry process of viruses into host cells is complex and involves stable but transient multivalent interactions with different cell surface receptors. The initial contact of several viruses begins with attachment to heparan sulfate (HS) proteoglycans on the cell surface, which results in a cascade of events that end up with virus entry. The development of antiviral agents based on multivalent interactions to shield virus particles and block initial interactions with cellular receptors has attracted attention in antiviral research. Here, we designed nanogels with different degrees of flexibility based on dendritic polyglycerol sulfate to mimic cellular HS. The designed nanogels are nontoxic and broad-spectrum, can multivalently interact with viral glycoproteins, shield virus surfaces, and efficiently block infection. We also visualized virus-nanogel interactions as well as the uptake of nanogels by the cells through clathrin-mediated endocytosis using confocal microscopy. As many human viruses attach to the cells through HS moieties, we introduce our flexible nanogels as robust inhibitors for these viruses.
KW  - multivalent
KW  - herpes simplex virus
KW  - heparan sulfate
KW  - nanoparticles
KW  - click chemistry
KW  - polyglycerol
Y1  - 2018
U6  - https://doi.org/10.1021/acsnano.8b01616
SN  - 1936-0851
SN  - 1936-086X
VL  - 12
IS  - 7
SP  - 6429
EP  - 6442
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Dal Bianco, Andrea
A1  - Wischke, Christian
A1  - Zhou, Shuo
A1  - Lendlein, Andreas
T1  - Controlling surface properties and permeability of polyglycerol network films
JF  - Polymers for advanced technologies
N2  - While branched polyglycerol (PG)-based molecules are well established as hydrophilic particles, the capacity of utilizing PG in bulk materials and opportunities arising by their further surface functionalization have only recently been considered. Here we investigated how the mold used in PG network synthesis may affect surface composition and how the permeability of substances through PG can be controlled by altering network structure, i.e. introducing 20mol% oligoethylene glycol (OEG) bifunctional spacer molecules. Overall, PG-based bulk network materials were shown to be tailorable, hydrophilic, low swelling and relatively stiff polyether-based materials, with low impact of salt onto material properties. Based on these features, but also on the principal capacity of free hydroxyl groups to be used for functionalization reactions, these materials may be an interesting platform for medical and technical applications, e.g. as diffusion-rate controlling membrane in aqueous environment. Copyright (c) 2016 John Wiley & Sons, Ltd.
KW  - polyglycerol
KW  - surface properties
KW  - diffusion
KW  - network structure
Y1  - 2017
U6  - https://doi.org/10.1002/pat.3917
SN  - 1042-7147
SN  - 1099-1581
VL  - 28
SP  - 1263
EP  - 1268
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Lange, Maik
A1  - Braune, Steffen
A1  - Luetzow, Karola
A1  - Richau, Klaus
A1  - Scharnagl, Nico
A1  - Weinhart, Marie
A1  - Neffe, Axel T.
A1  - Jung, Friedrich
A1  - Haag, Rainer
A1  - Lendlein, Andreas
T1  - Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity
JF  - Macromolecular rapid communications
N2  - Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
KW  - hemocompatibility
KW  - poly(ethylene glycol)
KW  - polyglycerol
KW  - polyimides
KW  - surface chemistry
Y1  - 2012
U6  - https://doi.org/10.1002/marc.201200426
SN  - 1022-1336
VL  - 33
IS  - 17
SP  - 1487
EP  - 1492
PB  - Wiley-VCH
CY  - Weinheim
ER  -