TY  - JOUR
A1  - Basaran, Nursen
A1  - Duydu, Yalcin
A1  - Ustundag, Aylin
A1  - Taner, Gokce
A1  - Aydin, Sevtap
A1  - Anlar, Hatice Gul
A1  - Yalcin, Can Özgür
A1  - Bacanli, Merve
A1  - Aydos, Kaan
A1  - Atabekoglu, Cem Somer
A1  - Golka, Klaus
A1  - Ickstadt, Katja
A1  - Schwerdtle, Tanja
A1  - Werner, Matthias
A1  - Meyer, Sören
A1  - Bolt, Hermann M.
T1  - Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions
JF  - Mutation Research/Genetic Toxicology and Environmental Mutagenesis
N2  - Industrial production and use of boron compounds have increased during the last decades, especially for the manufacture of borosilicate glass, fiberglass, metal alloys and flame retardants. This study was conducted in two districts of Balikesir; Bandirma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandirma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandirma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in the DNA damage in blood, sperm and buccal cells was observed in the residents exposed to boron both occupationally and environmentally (p = 0.861) for Comet test in the sperm samples, p = 0.116 for Comet test in the lymphocyte samples, p = 0.042 for micronucleus (MN) test, p = 0.955 for binucleated cells (BN), p = 1.486 for condensed chromatin (CC), p = 0.455 for karyorrhectic cells (KHC), p = 0.541 for karyolitic cells (KLY), p = 1.057 for pyknotic cells (PHC), p = 0.331 for nuclear bud (NBUD)). No correlations were seen between blood boron levels and tail intensity values of the sperm samples, lymphocyte samples, frequencies of MN, BN, KHC, KYL, PHC and NBUD. The results of this study came to the same conclusions of the previous studies that boron does not induce DNA damage even under extreme exposure conditions.
KW  - Boric acid
KW  - Boron exposure
KW  - DNA damage
KW  - Comet assay
Y1  - 2019
U6  - https://doi.org/10.1016/j.mrgentox.2018.12.013
SN  - 1383-5718
SN  - 1879-3592
VL  - 843
SP  - 33
EP  - 39
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Duydu, Yalcin
A1  - Basaran, Nursen
A1  - Yalcin, Can Özgür
A1  - Ustundag, Aylin
A1  - Aydin, Sevtap
A1  - Anlar, Hatice Gul
A1  - Bacanli, Merve
A1  - Aydos, Kaan
A1  - Atabekoglu, Cem Somer
A1  - Golka, Klaus
A1  - Ickstadt, Katja
A1  - Schwerdtle, Tanja
A1  - Werner, Matthias
A1  - Bolt, Hermann M.
T1  - Boron-exposed male workers in Turkey
BT  - no change in sperm Y:X chromosome ratio and in offspring's sex ratio
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 +/- 18.32 mg B/day, 1643.23 +/- 965.44 ng B/g semen and 553.83 +/- 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.
KW  - Paternal exposure
KW  - Boron exposure
KW  - Y:X chromosome ratio
KW  - Sex ratio at birth
Y1  - 2019
U6  - https://doi.org/10.1007/s00204-019-02391-z
SN  - 0340-5761
SN  - 1432-0738
VL  - 93
IS  - 3
SP  - 743
EP  - 751
PB  - Springer
CY  - Heidelberg
ER  -