TY  - JOUR
A1  - Hörmann, Simon
A1  - dos Santos, Luara Ferreira
A1  - Morkisch, Nadine
A1  - Jettkowski, Katrin
A1  - Sillis, Moran
A1  - Devan, Hemakumar
A1  - Kanagasabai, Parimala S.
A1  - Schmidt, Henning
A1  - Krüger, Jörg
A1  - Dohle, Christian
A1  - Regenbrecht, Holger
A1  - Hale, Leigh
A1  - Cutfield, Nicholas J.
T1  - Computerised mirror therapy with Augmented Reflection Technology for early stroke rehabilitation
BT  - clinical feasibility and integration as an adjunct therapy
JF  - Disability and rehabilitation : an international, multidisciplinary journal
N2  - Purpose: New rehabilitation strategies for post-stroke upper limb rehabilitation employing visual stimulation show promising results, however, cost-efficient and clinically feasible ways to provide these interventions are still lacking. An integral step is to translate recent technological advances, such as in virtual and augmented reality, into therapeutic practice to improve outcomes for patients. This requires research on the adaptation of the technology for clinical use as well as on the appropriate guidelines and protocols for sustainable integration into therapeutic routines. Here, we present and evaluate a novel and affordable augmented reality system (Augmented Reflection Technology, ART) in combination with a validated mirror therapy protocol for upper limb rehabilitation after stroke. Results: The results showed that the combination and application of the Berlin Protocol for Mirror Therapy together with ART was feasible for clinical use. This combination was integrated into the therapeutic plan of subacute stroke patients at the two clinical locations where the second part of this research was conducted. Conclusions: Our findings pave the way for using technology to provide mirror therapy in clinical settings and show potential for the more effective use of inpatient time and enhanced recoveries for patients. IMPLICATIONS FOR REHABILITATION Computerised Mirror Therapy is feasible for clinical use Augmented Reflection Technology can be integrated as an adjunctive therapeutic intervention for subacute stroke patients in an inpatient setting Virtual Rehabilitation devices such as Augmented Reflection Technology have considerable potential to enhance stroke rehabilitation
KW  - Augmented reality
KW  - virtual reality
KW  - usability
KW  - user experience
KW  - upper limb
KW  - visual illusion
Y1  - 2017
U6  - https://doi.org/10.1080/09638288.2017.1291765
SN  - 0963-8288
SN  - 1464-5165
VL  - 39
SP  - 1503
EP  - 1514
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Jedrusik-Bode, Monika
A1  - Studencka, Maja
A1  - Smolka, Christian
A1  - Baumann, Tobias
A1  - Schmidt, Henning
A1  - Kampf, Jan
A1  - Paap, Franziska
A1  - Martin, Sophie
A1  - Tazi, Jamal
A1  - Müller, Kristian M.
A1  - Krüger, Marcus
A1  - Braun, Thomas
A1  - Bober, Eva
T1  - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
JF  - Journal of cell science
N2  - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.
KW  - C. elegans
KW  - G3BP
KW  - SIRT6
KW  - Sirtuins
KW  - Stress
KW  - Stress granules
Y1  - 2013
U6  - https://doi.org/10.1242/jcs.130708
SN  - 0021-9533
SN  - 1477-9137
VL  - 126
IS  - 22
SP  - 5166
EP  - +
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - THES
A1  - Schmidt, Henning
T1  - Dynamisch veränderbare Betriebssystemstrukturen
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Schmidt, Henning
A1  - Berg, Ralph
A1  - Büttner, Lars
A1  - Cordson, Jörg
A1  - Luther, Eva-Maria
A1  - Schön, Friedrich
T1  - PEACE - Beispiel einer anwendungsorientierten Betriebssystemstruktur
Y1  - 1996
ER  -