TY  - JOUR
A1  - Haack, Timm
A1  - Abdelilah-Seyfried, Salim
T1  - The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
JF  - Development : Company of Biologists
N2  - Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.
KW  - Endocardium
KW  - Cardiac development
KW  - Hemodynamics
KW  - Bmp
KW  - Kruppel-like factor 2
KW  - Vegf
KW  - Mechanotransduction
KW  - Zebrafish
KW  - Mouse
Y1  - 2016
U6  - https://doi.org/10.1242/dev.131425
SN  - 0950-1991
SN  - 1477-9129
VL  - 143
SP  - 373
EP  - 386
PB  - Company of Biologists Limited
CY  - Cambridge
ER  -