TY - GEN A1 - Freitag, Nils A1 - Weber, Pia Deborah A1 - Sanders, Tanja Christiane A1 - Schulz, Holger A1 - Bloch, Wilhelm A1 - Schumann, Moritz T1 - High-intensity interval training and hyperoxia during chemotherapy BT - A case report about the feasibility, safety and physical functioning in a colorectal cancer patient T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Introduction: We conducted a case study to examine the feasibility and safety of high-intensity interval training (HIIT) with increased inspired oxygen content in a colon cancer patient undergoing chemotherapy. A secondary purpose was to investigate the effects of such training regimen on physical functioning. Case presentation: A female patient (51 years; 49.1 kg; 1.65 m; tumor stage: pT3, pN2a (5/29), pM1a (HEP), L0, V0, R0) performed 8 sessions of HIIT (5 × 3 minutes at 90% of Wmax, separated by 2 minutes at 45% Wmax) with an increased inspired oxygen fraction of 30%. Patient safety, training adherence, cardiorespiratory fitness (peak oxygen uptake and maximal power output during an incremental cycle ergometer test), autonomous nervous function (i.e., heart rate variability during an orthostatic test) as well as questionnaire-assessed quality of life (EORTC QLQ-C30) were evaluated before and after the intervention. No adverse events were reported throughout the training intervention and a 3 months follow-up. While the patient attended all sessions, adherence to total training time was only 51% (102 of 200 minutes; mean training time per session 12:44 min:sec). VO2peak and Wmax increased by 13% (from 23.0 to 26.1 mL min kg−1) and 21% (from 83 to 100 W), respectively. Heart rate variability represented by the root mean squares of successive differences both in supine and upright positions were increased after the training by 143 and 100%, respectively. The EORTC QLQ-C30 score for physical functioning (7.5%) as well as the global health score (10.7%) improved, while social function decreased (17%). Conclusions: Our results show that a already short period of HIIT with concomitant hyperoxia was safe and feasible for a patient undergoing chemotherapy for colon cancer. Furthermore, the low overall training adherence of only 51% and an overall low training time per session (∼13 minutes) was sufficient to induce clinically meaningful improvements in physical functioning. However, this case also underlines that intensity and/or length of the HIIT-bouts might need further adjustments to increase training compliance. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 453 KW - carcinoma KW - chemo-toxicity KW - exercise therapy KW - fatigue KW - gastrointestinal cancer KW - heart rate variability KW - high-intensity interval training KW - solid tumor Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414112 IS - 453 ER - TY - JOUR A1 - Freitag, Nils A1 - Weber, Pia Deborah A1 - Sanders, Tanja Christiane A1 - Schulz, Holger A1 - Bloch, Wilhelm A1 - Schumann, Moritz T1 - High-intensity interval training and hyperoxia during chemotherapy BT - A case report about the feasibility, safety and physical functioning in a colorectal cancer patient JF - Medicine N2 - Introduction: We conducted a case study to examine the feasibility and safety of high-intensity interval training (HIIT) with increased inspired oxygen content in a colon cancer patient undergoing chemotherapy. A secondary purpose was to investigate the effects of such training regimen on physical functioning. Case presentation: A female patient (51 years; 49.1 kg; 1.65 m; tumor stage: pT3, pN2a (5/29), pM1a (HEP), L0, V0, R0) performed 8 sessions of HIIT (5 × 3 minutes at 90% of Wmax, separated by 2 minutes at 45% Wmax) with an increased inspired oxygen fraction of 30%. Patient safety, training adherence, cardiorespiratory fitness (peak oxygen uptake and maximal power output during an incremental cycle ergometer test), autonomous nervous function (i.e., heart rate variability during an orthostatic test) as well as questionnaire-assessed quality of life (EORTC QLQ-C30) were evaluated before and after the intervention. No adverse events were reported throughout the training intervention and a 3 months follow-up. While the patient attended all sessions, adherence to total training time was only 51% (102 of 200 minutes; mean training time per session 12:44 min:sec). VO2peak and Wmax increased by 13% (from 23.0 to 26.1 mL min kg−1) and 21% (from 83 to 100 W), respectively. Heart rate variability represented by the root mean squares of successive differences both in supine and upright positions were increased after the training by 143 and 100%, respectively. The EORTC QLQ-C30 score for physical functioning (7.5%) as well as the global health score (10.7%) improved, while social function decreased (17%). Conclusions: Our results show that a already short period of HIIT with concomitant hyperoxia was safe and feasible for a patient undergoing chemotherapy for colon cancer. Furthermore, the low overall training adherence of only 51% and an overall low training time per session (∼13 minutes) was sufficient to induce clinically meaningful improvements in physical functioning. However, this case also underlines that intensity and/or length of the HIIT-bouts might need further adjustments to increase training compliance. KW - carcinoma KW - chemo-toxicity KW - exercise therapy KW - fatigue KW - gastrointestinal cancer KW - heart rate variability KW - high-intensity interval training KW - solid tumor Y1 - 2018 U6 - https://doi.org/10.1097/MD.0000000000011068 SN - 1536-5964 SN - 0025-7974 VL - 97 IS - 24 SP - 1 EP - 7 PB - Lippincott Williams & Wilkins CY - Baltimore, Md. ER - TY - JOUR A1 - Wendt, Julia A1 - Weymar, Mathias A1 - Junge, Martin A1 - Hamm, Alfons O. A1 - Lischke, Alexander T1 - Heartfelt memories BT - Cardiac vagal tone correlates with increased memory for untrustworthy faces JF - Emotion : a new journal from the American Psychological Association N2 - During social interactions, we rapidly judge others’ trustworthiness on basis of their facial characteristics. Face-based trustworthiness judgments may not only affect our current but also our future interactions because we seem to be more inclined to remember untrustworthy than trustworthy faces. Memory formation of salient stimuli like untrustworthy faces may be modulated by the interplay between the autonomic and central nervous system, which can be indexed by changes in vagally mediated heart rate variability (HRV). To test this assumption, we investigated whether differences in HRV would be associated with differences in memory formation of untrustworthy faces in a sample of healthy participants (n = 34, all female). Untrustworthy faces were remembered more accurately than trustworthy faces, albeit only by participants with high and not low HRV. Across participants, increased memory accuracy for untrustworthy faces was associated with increased HRV. We discuss these findings in the context of neurobiological theories regarding the interplay between the autonomic and central nervous system during the regulation of autonomic, emotional and cognitive processes. (PsycInfo Database Record KW - trustworthiness KW - face memory KW - heart rate variability KW - amygdala KW - prefrontal cortex Y1 - 2018 U6 - https://doi.org/10.1037/emo0000396 SN - 1528-3542 SN - 1931-1516 VL - 19 IS - 1 SP - 178 EP - 182 PB - American Psychological Association CY - Washington ER - TY - GEN A1 - Topçu, Çağdaş A1 - Frühwirth, Matthias A1 - Moser, Maximilian A1 - Rosenblum, Michael A1 - Pikovskij, Arkadij T1 - Disentangling respiratory sinus arrhythmia in heart rate variability records T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Objective: Several different measures of heart rate variability, and particularly of respiratory sinus arrhythmia, are widely used in research and clinical applications. For many purposes it is important to know which features of heart rate variability are directly related to respiration and which are caused by other aspects of cardiac dynamics. Approach: Inspired by ideas from the theory of coupled oscillators, we use simultaneous measurements of respiratory and cardiac activity to perform a nonlinear disentanglement of the heart rate variability into the respiratory-related component and the rest. Main results: The theoretical consideration is illustrated by the analysis of 25 data sets from healthy subjects. In all cases we show how the disentanglement is manifested in the different measures of heart rate variability. Significance: The suggested technique can be exploited as a universal preprocessing tool, both for the analysis of respiratory influence on the heart rate and in cases when effects of other factors on the heart rate variability are in focus. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 913 KW - respiratory sinus arrhythmia KW - heart rate variability KW - coupled oscillators model KW - phase dynamics KW - data analysis Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-436315 SN - 1866-8372 IS - 913 ER - TY - JOUR A1 - Topçu, Çağdaş A1 - Frühwirth, Matthias A1 - Moser, Maximilian A1 - Rosenblum, Michael A1 - Pikovskij, Arkadij T1 - Disentangling respiratory sinus arrhythmia in heart rate variability records JF - Physiological Measurement N2 - Objective: Several different measures of heart rate variability, and particularly of respiratory sinus arrhythmia, are widely used in research and clinical applications. For many purposes it is important to know which features of heart rate variability are directly related to respiration and which are caused by other aspects of cardiac dynamics. Approach: Inspired by ideas from the theory of coupled oscillators, we use simultaneous measurements of respiratory and cardiac activity to perform a nonlinear disentanglement of the heart rate variability into the respiratory-related component and the rest. Main results: The theoretical consideration is illustrated by the analysis of 25 data sets from healthy subjects. In all cases we show how the disentanglement is manifested in the different measures of heart rate variability. Significance: The suggested technique can be exploited as a universal preprocessing tool, both for the analysis of respiratory influence on the heart rate and in cases when effects of other factors on the heart rate variability are in focus. KW - respiratory sinus arrhythmia KW - heart rate variability KW - coupled oscillators model KW - phase dynamics KW - data analysis Y1 - 2018 U6 - https://doi.org/10.1088/1361-6579/aabea4 SN - 0967-3334 SN - 1361-6579 VL - 39 IS - 5 PB - IOP Publ. Ltd. CY - Bristol ER -