TY  - JOUR
A1  - Schmaelzlin, Elmar
A1  - Moralejo, Benito
A1  - Rutowska, Monika
A1  - Monreal-Ibero, Ana
A1  - Sandin, Christer
A1  - Tarcea, Nicolae
A1  - Popp, Juergen
A1  - Roth, Martin M.
T1  - Raman imaging with a fiber-coupled multichannel spectrograph
JF  - Sensors
N2  - Until now, spatially resolved Raman Spectroscopy has required to scan a sample under investigation in a time-consuming step-by-step procedure. Here, we present a technique that allows the capture of an entire Raman image with only one single exposure. The Raman scattering arising from the sample was collected with a fiber-coupled high-performance astronomy spectrograph. The probe head consisting of an array of 20 x 20 multimode fibers was linked to the camera port of a microscope. To demonstrate the high potential of this new concept, Raman images of reference samples were recorded. Entire chemical maps were received without the need for a scanning procedure.
KW  - multichannel Raman spectroscopy
KW  - astronomy spectrograph
KW  - optical fiber bundle
KW  - Raman imaging
Y1  - 2014
U6  - https://doi.org/10.3390/s141121968
SN  - 1424-8220
VL  - 14
IS  - 11
SP  - 21968
EP  - 21980
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schmälzlin, Elmar Gerd
A1  - Moralejo, Benito
A1  - Gersonde, Ingo
A1  - Schleusener, Johannes
A1  - Darvin, Maxim E.
A1  - Thiede, Gisela
A1  - Roth, Martin M.
T1  - Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination
JF  - Journal of biomedical optics
N2  - Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
KW  - Raman spectroscopy
KW  - cancer diagnosis
KW  - Raman imaging
KW  - multichannel
KW  - astronomy
KW  - epidermis
KW  - dermis
Y1  - 2018
U6  - https://doi.org/10.1117/1.JBO.23.10.105001
SN  - 1083-3668
SN  - 1560-2281
VL  - 23
IS  - 10
PB  - SPIE
CY  - Bellingham
ER  -