TY  - JOUR
A1  - Lombardo, Verónica A.
A1  - Heise, Melina
A1  - Moghtadaei, Motahareh
A1  - Bornhorst, Dorothee
A1  - Männer, Jörg
A1  - Abdelilah-Seyfried, Salim
T1  - Morphogenetic control of zebrafish cardiac looping by Bmp signaling
JF  - Development : Company of Biologists
N2  - Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. High-resolution 4D live imaging of mosaically labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire a conical cell shape, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces S-shaping of the heart. During cardiac looping, bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of bone morphogenetic protein signaling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This description of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects.
KW  - BMP
KW  - Wnt
KW  - Cardiac looping
KW  - Hemodynamics
KW  - Zebrafish
Y1  - 2019
U6  - https://doi.org/10.1242/dev.180091
SN  - 0950-1991
SN  - 1477-9129
VL  - 146
IS  - 22
PB  - The Company of Biologists Ltd
CY  - Cambridge
ER  -