TY  - JOUR
A1  - Wittenbecher, Clemens
A1  - Kuxhaus, Olga
A1  - Boeing, Heiner
A1  - Stefan, Norbert
A1  - Schulze, Matthias Bernd
T1  - Associations of short stature and components of height with incidence of type 2 diabetes
BT  - mediating effects of cardiometabolic risk factors
JF  - Diabetologia : journal of the European Association for the Study of Diabetes (EASD)
N2  - Aims/hypothesis This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. Methods A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. Results After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. Conclusions/interpretation We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile.
KW  - Adult height
KW  - Blood pressure
KW  - Diabetes incidence
KW  - Leg length
KW  - Liver fat
KW  - Short stature
KW  - Trunk length
Y1  - 2019
U6  - https://doi.org/10.1007/s00125-019-04978-8
SN  - 0012-186X
SN  - 1432-0428
VL  - 62
IS  - 12
SP  - 2211
EP  - 2221
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Lu, Yong Ping
A1  - Tsuprykov, Oleg
A1  - Vignon-Zellweger, Nicolas
A1  - Heiden, Susi
A1  - Hocher, Berthold
T1  - Global Overexpression of ET-1 Decreases Blood Pressure - A Systematic Review and Meta-Analysis of ET-1 Transgenic Mice
JF  - Naunyn-Schmiedeberg's archives of pharmacology
N2  - Background/Aims: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially counteracting mechanisms on blood pressure, a systematic meta-analysis was performed. Methods: Based on the principles of Cochrane systematic reviews, we searched in major literature databases - MEDLINE (PubMed), Embase, Google Scholar, and the China Biological Medicine Database (CBM-disc) - for articles relevant to the topic of the blood pressure phenotype of endothelin-1 transgenic (ET-1+/+) mice from January 1, 1988 to March 31, 2016. Review Manager Version 5.0 (Rev-Man 5.0) software was applied for statistical analysis. In total thirteen studies reported blood pressure data. Results: The meta-analysis of blood pressure data showed that homozygous ET-1 transgenic mice (ET-1+/+ mice) had a significantly lower blood pressure as compared to WT mice (mean difference:-2.57 mmHg, 95% CI: -4.98 similar to -0.16, P = 0.04), with minimal heterogeneity (P = 0.86). A subgroup analysis of mice older than 6 months revealed that the blood pressure difference between ET-1+/+ mice and WT mice was even more pronounced (mean difference: -6.19 mmHg, 95% CI: -10.76 similar to -1.62, P = 0.008), with minimal heterogeneity (P = 0.91). Conclusion: This meta-analysis provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure. (C) 2016 The Author(s) Published by S. Karger AG, Basel
KW  - Endothelin-1 transgenic mice
KW  - Blood pressure
KW  - Kidney weight
KW  - Heart weight
Y1  - 2016
U6  - https://doi.org/10.1159/000450567
SN  - 1420-4096
SN  - 1423-0143
VL  - 41
SP  - 770
EP  - 780
PB  - Karger
CY  - Basel
ER  -