TY  - JOUR
A1  - Gilles, Maria
A1  - Otto, Henrike
A1  - Wolf, Isabell A. C.
A1  - Scharnholz, Barbara
A1  - Peus, Verena
A1  - Schredl, Michael
A1  - Suetterlin, Marc W.
A1  - Witt, Stephanie H.
A1  - Rietschel, Marcella
A1  - Laucht, Manfred
A1  - Deuschle, Michael
T1  - Maternal hypothalamus-pituitary-adrenal (HPA) system activity and stress measures at birth
JF  - Psychoneuroendocrinology
N2  - Background: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome. Methods: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36.8 +/- 1.9 weeks of gestational age) and their singleton neonates were studied. We investigated the impact of different prenatal stress indices derived from six stress variables (perceived stress, specific prenatal worries, negative life events, symptoms of depression, trait anxiety, neuroticism) and diurnal maternal saliva cortisol secretion on gestational age and anthropometric measures at birth.
KW  - Early life stress
KW  - Gestational age
KW  - Anthropometric measures at birth
KW  - Cortisol
KW  - Prenatal distress
KW  - Pregnancy
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.04.022
SN  - 0306-4530
VL  - 94
SP  - 152
EP  - 161
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Wolf, Isabell Ann-Cathrin
A1  - Gilles, Maria
A1  - Peus, Verena
A1  - Scharnholz, Barbara
A1  - Seibert, Julia
A1  - Jennen-Steinmetz, Christine
A1  - Krumm, Bertram
A1  - Deuschle, Michael
A1  - Laucht, Manfred
T1  - Impact of prenatal stress on the dyadic behavior of mothers and their 6-month-old infants during a play situation: role of different dimensions of stress
JF  - Journal of neural transmission
KW  - Prenatal stress
KW  - Cortisol
KW  - Mother-infant behavior
KW  - Pregnancy
KW  - Stress inoculation
Y1  - 2017
U6  - https://doi.org/10.1007/s00702-017-1770-3
SN  - 0300-9564
SN  - 1435-1463
VL  - 124
SP  - 1251
EP  - 1260
PB  - Springer
CY  - Wien
ER  - 
TY  - JOUR
A1  - Wolf, Isabell Ann-Cathrin
A1  - Gilles, Maria
A1  - Peus, Verena
A1  - Scharnholz, Barbara
A1  - Seibert, Julia
A1  - Jennen-Steinmetz, Christine
A1  - Krumm, Bertram
A1  - Rietschel, Marcella
A1  - Deuschle, Michael
A1  - Laucht, Manfred
T1  - Impact of prenatal stress on mother-infant dyadic behavior during the still-face paradigm
JF  - Borderline Personality Disorder and Emotion Dysregulation : the official journal of the National Education Alliance for Borderline Personality Disorder (NEA.BPD) and Dachverband Dialektisch Behaviorale Therapie (DDBT)
N2  - Background:
Mother-infant interaction provides important training for the infant’s ability to cope with stress and the development of resilience. Prenatal stress (PS) and its impact on the offspring’s development have long been a focus of stress research, with studies highlighting both harmful and beneficial effects. The aim of the current study was to examine the possible influence of both psychological stress and hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy with mother-child dyadic behavior following stress exposure.
Methods:
The behavior of 164 mother-infant dyads during the still-face situation was filmed at six months postpartum and coded into three dyadic patterns: 1) both positive, 2) infant protesting-mother positive, and 3) infant protesting-mother negative. PS exposure was assessed prenatally according to psychological measures (i.e., psychopathological, perceived and psychosocial PS; n = 164) and HPA axis activity measures (maternal salivary cortisol, i.e., cortisol decline and area under the curve with respect to ground (AUCg); n = 134).
Results:
Mother-infant dyads in both the high- and low-stress groups showed decreasing positive and increasing negative dyadic behavior in the reunion episode, which is associated with the well-known “still-face” and “carry-over” effect. Furthermore, mother-infant dyads with higher psychosocial PS exhibited significantly more positive dyadic behavior than the low psychosocial PS group in the first play episode, but not in the reunion episode. Similarly, mother-infant dyads with high HPA axis activity (i.e. high AUCg) but steeper diurnal cortisol decline (i.e. cortisol decline) displayed significantly less negative behavior in the reunion episode than dyads with low HPA axis activity. No significant results were found for psychopathological stress and perceived stress.
Conclusions:
The results suggest a beneficial effect of higher psychosocial PS and higher prenatal maternal HPA axis activity in late gestation, which is in line with “stress inoculation” theories.
KW  - Prenatal stress
KW  - Face-to-face still-face paradigm
KW  - Resilience
KW  - Psychosocial stress
KW  - Cortisol
Y1  - 2018
U6  - https://doi.org/10.1186/s40479-018-0078-8
SN  - 2051-6673
VL  - 5
PB  - BioMed Central
CY  - London
ER  -