TY  - GEN
A1  - McQuade, D. Tyler
A1  - O'Brien, Alexander G.
A1  - Dörr, Markus
A1  - Rajaratnam, Rajathees
A1  - Eisold, Ursula
A1  - Monnanda, Bopanna
A1  - Nobuta, Tomoya
A1  - Löhmannsröben, Hans-Gerd
A1  - Meggers, Eric
A1  - Seeberger, Peter H.
T1  - Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization
N2  - Pyridocarbazoles when ligated to transition metals yield high affinity kinase inhibitors. While batch photocyclizations enable the synthesis of these heterocycles, the non-oxidative Mallory reaction only provides modest yields and difficult to purify mixtures. We demonstrate here that a flow-based Mallory cyclization provides superior results and enables observation of a clear isobestic point. The flow method allowed us to rapidly synthesize ten pyridocarbazoles and for the first time to document their interesting photophysical attributes. Preliminary characterization reveals that these molecules might be a new class of fluorescent bioprobe.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 246 
KW  - protein-kinase inhibitors
KW  - continuous-flow
KW  - photochemical synthesis
KW  - light
KW  - efficient
KW  - phenanthrenes
KW  - complexes
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95214
SP  - 4067
EP  - 4070
ER  - 
TY  - GEN
A1  - Eich, Susanne
A1  - Schmälzlin, Elmar
A1  - Löhmannsröben, Hans-Gerd
T1  - Distributed fiber optical sensing of oxygen with optical time domain reflectometry
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - In many biological and environmental applications spatially resolved sensing of molecular oxygen is desirable. A powerful tool for distributed measurements is optical time domain reflectometry (OTDR) which is often used in the field of telecommunications. We combine this technique with a novel optical oxygen sensor dye, triangular-[4] phenylene (TP), immobilized in a polymer matrix. The TP luminescence decay time is 86 ns. The short decay time of the sensor dye is suitable to achieve a spatial resolution of some meters. In this paper we present the development and characterization of a reflectometer in the UV range of the electromagnetic spectrum as well as optical oxygen sensing with different fiber arrangements.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1085 
KW  - OTDR
KW  - optical sensing
KW  - molecular oxygen
KW  - triangular-[4] phenylene
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-476659
SN  - 1866-8372
IS  - 1085
ER  -