TY  - JOUR
A1  - Marques, Telma S.
A1  - Smialek, Malgorzata A.
A1  - Schürmann, Robin
A1  - Bald, Ilko
A1  - Raposo, Maria
A1  - Eden, Sam
A1  - Mason, Nigel J.
T1  - Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles
JF  - The European physical journal : D, Atomic, molecular, optical and plasma physics
N2  - Halogenated uracil derivatives are of great interest in modern cancer therapy, either as chemotherapeutics or radiosensitisers depending on their halogen atom. This work applies UV-Vis spectroscopy to study the radiation damage of uracil, 5-bromouracil and 5-fluorouracil dissolved in water in the presence of gold nanoparticles upon irradiation with an Nd:YAG ns-pulsed laser operating at 532 nm at different fluences. Gold nanoparticles absorb light efficiently by their surface plasmon resonance and can significantly damage DNA in their vicinity by an increase of temperature and the generation of reactive secondary species, notably radical fragments and low energy electrons. A recent study using the same experimental approach characterized the efficient laser-induced decomposition of the pyrimidine ring structure of 5-bromouracil mediated by the surface plasmon resonance of gold nanoparticles. The present results show that the presence of irradiated gold nanoparticles decomposes the ring structure of uracil and its halogenated derivatives with similar efficiency. In addition to the fragmentation of the pyrimidine ring, for 5-bromouracil the cleavage of the carbon-halogen bond could be observed, whereas for 5-fluorouracil this reaction channel was inhibited. Locally-released halogen atoms can react with molecular groups within DNA, hence this result indicates a specific mechanism by which doping with 5-bromouracil can enhance DNA damage in the proximity of laser irradiated gold nanoparticles.
Y1  - 2020
U6  - https://doi.org/10.1140/epjd/e2020-10208-3
SN  - 1434-6060
SN  - 1434-6079
VL  - 74
IS  - 11
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Bald, Ilko
A1  - Solov'yov, Ilia A.
A1  - Mason, Nigel J.
A1  - Solov'yov, Andrey V.
T1  - Special issue
BT  - dynamics of systems on the nanoscale (2018). Editorial
JF  - The European physical journal. D, Atomic, molecular, optical and plasma physics
N2  - The structure, formation and dynamics of both animate and inanimate matter on the nanoscale are a highly interdisciplinary field of rapidly emerging research engaging a broad community encompassing experimentalists, theorists, and technologists. It is relevant for a large variety of molecular and nanosystems of different origin and composition and concerns numerous phenomena originating from physics, chemistry, biology, or materials science. This Topical Issue presents a collection of original research papers devoted to different aspects of structure and dynamics on the nanoscale. Some of the contributions discuss specific applications of the research results in several modern technologies and in next generation medicine. Most of the works of this topical issue were reported at the Fifth International Conference on Dynamics of Systems on the Nanoscale (DySoN) - the premier forum for the presentation of cutting-edge research in this field that was held in Potsdam, Germany in October of 2018.
Y1  - 2020
U6  - https://doi.org/10.1140/epjd/e2020-10134-4
SN  - 1434-6060
SN  - 1434-6079
VL  - 74
IS  - 4
SP  - 75
EP  - 82
PB  - Springer
CY  - Berlin
ER  -