TY  - JOUR
A1  - Kolocouris, Antonios
A1  - Zervos, Nikolaos
A1  - De Proft, Frank
A1  - Koch, Andreas
T1  - Improper Hydrogen Bonded Cyclohexane C-H-ax center dot center dot center dot Y-ax Contacts theoretical predictions and experimental Evidence from H-1 NMR Spectroscopy of Suitable Axial Cyclohexane Models
JF  - The journal of organic chemistry
N2  - C-H-ax center dot center dot center dot Y-ax are a textbook prototype of steric hindrance in organic chemistry. The nature of these contacts is investigated in this work. MP2/6-31+G(d,p) calculations predicted the presence of improper hydrogen bonded C-H-ax center dot center dot center dot Y-ax of different strength in substituted cyclohexane rings. To support the theoretical predictions with experimental evidence, several synthetic 2-substituted adamantane analogues (1-24) with suitable improper H-bonded C-H-ax center dot center dot center dot Y-ax contacts of different strength were used as models of a substituted cyclohexane ring. The H-1 NMR signal separation, Delta delta(gamma-CH2), within the cyclohexane ring gamma-CH(2)s is raised when the MP2/6-31+G(d,p) calculated parameters, reflecting the strength of the H-bonded C-H-ax center dot center dot center dot Y-ax contact, are increased. In molecules with enhanced improper H-bonded contacts C-H-ax center dot center dot center dot Y-ax, like those having sterically crowded contacts (Y-ax = t-Bu) or contacts including considerable electrostatic attractions (Y-ax = O-C or O=C) the calculated DFT steric energies of the gamma-axial hydrogens are considerably reduced reflecting their electron cloud compression. The results suggest that the proton H-ax electron cloud compression, caused by the C-H-ax center dot center dot center dot Y-ax contacts, and the resulting increase in Delta delta(gamma-CH2) value can be effected not just from van der Waals spheres compression, but more generally from electrostatic attraction forces and van der Waals repulsion, both of which are improper H-bonding components.
Y1  - 2011
U6  - https://doi.org/10.1021/jo102353f
SN  - 0022-3263
VL  - 76
IS  - 11
SP  - 4432
EP  - 4443
PB  - American Chemical Society
CY  - Washington
ER  -