38473
2015
2015
eng
4622
4637
16
11
36
article
Wiley-Blackwell
Hoboken
1
--
--
--
Negative childhood experiences alter a prefrontal-insular-motor cortical network in healthy adults: A preliminary multimodal rsfMRI-fMRI-MRS-dMRI study
Research in humans and animals has shown that negative childhood experiences (NCE) can have long-term effects on the structure and function of the brain. Alterations have been noted in grey and white matter, in the brain's resting state, on the glutamatergic system, and on neural and behavioural responses to aversive stimuli. These effects can be linked to psychiatric disorder such as depression and anxiety disorders that are influenced by excessive exposure to early life stressors. The aim of the current study was to investigate the effect of NCEs on these systems. Resting state functional MRI (rsfMRI), aversion task fMRI, glutamate magnetic resonance spectroscopy (MRS), and diffusion magnetic resonance imaging (dMRI) were combined with the Childhood Trauma Questionnaire (CTQ) in healthy subjects to examine the impact of NCEs on the brain. Low CTQ scores, a measure of NCEs, were related to higher resting state glutamate levels and higher resting state entropy in the medial prefrontal cortex (mPFC). CTQ scores, mPFC glutamate and entropy, correlated with neural BOLD responses to the anticipation of aversive stimuli in regions throughout the aversion-related network, with strong correlations between all measures in the motor cortex and left insula. Structural connectivity strength, measured using mean fractional anisotropy, between the mPFC and left insula correlated to aversion-related signal changes in the motor cortex. These findings highlight the impact of NCEs on multiple inter-related brain systems. In particular, they highlight the role of a prefrontal-insular-motor cortical network in the processing and responsivity to aversive stimuli and its potential adaptability by NCEs. Hum Brain Mapp 36:4622-4637, 2015. (c) 2015 Wiley Periodicals, Inc.
Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging
10.1002/hbm.22941
26287448
1065-9471
1097-0193
wos:2015
WOS:000364219500028
Duncan, NW (reprint author), Taipei Med Univ, Grad Inst Humanities Med, 250 Wu Xin St, Taipei 11031, Taiwan., niall.w.duncan@gmail.com
Biotechnology Research Center (BTRC) [P41 RR008079, P41 EB015894, NCC
P30 NS057091]; Canadian Institutes of Health Research; Michael Smith
Foundation
Niall W. Duncan
Dave J. Hayes
Christine Wiebking
Brice Tiret
Karin Pietruska
David Q. Chen
Pierre Rainville
Malgorzata Marjanska
Omar Ayad
Julien Doyon
Mojgan Hodaie
Georg Northoff
eng
uncontrolled
affect
eng
uncontrolled
early life stress
eng
uncontrolled
brain networks
eng
uncontrolled
aversion
eng
uncontrolled
resting state
eng
uncontrolled
mood disorder
Referiert
Department Sport- und Gesundheitswissenschaften
Institut für Sportwissenschaft
39006
2015
2015
eng
33
9
article
Frontiers Research Foundation
Lausanne
1
--
--
--
Interoception in insula subregions as a possible state marker for depression - an exploratory fMRI study investigating healthy, depressed and remitted participants
Background: Interoceptive awareness, the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored.
Methods: A well-established fMRI paradigm for studying interoceptive awareness (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups.
Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences.
Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst healthy participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus.
Frontiers in behavioral neuroscience
10.3389/fnbeh.2015.00082
25914633
1662-5153
wos:2015
UNSP 82
WOS:000352276000001
Wiebking, C (reprint author), Univ Ottawa, Mind Brain Imaging & Neuroeth, Mental Hlth Res Inst, 1145 Carling Ave,Room 6437, Ottawa, ON K1Z 7K4, Canada., Christine.Wiebking@gmx.de
Lilly Germany; Salus Foundation; Hope of Depression Research Foundation;
German Research Foundation (DFG) [Sonderforschungsbereich 779-A6]; IMHR
Postdoctoral Fellowship
Christine Wiebking
Moritz de Greck
Niall W. Duncan
Claus Tempelmann
Malek Bajbouj
Georg Northoff
eng
uncontrolled
major depressive disorder
eng
uncontrolled
interoceptive awareness
eng
uncontrolled
insula
eng
uncontrolled
remission
eng
uncontrolled
neuroimaging
eng
uncontrolled
fMRI
Strukturbereich Kognitionswissenschaften
Referiert
Open Access
Exzellenzbereich Kognitionswissenschaften
7515
2015
2015
eng
14
9
article
Frontiers Research Foundation
Lausanne
1
2015-04-13
2015-04-10
--
Interoception in insula subregions as a possible state marker for depression
Background: Interoceptive awareness (iA), the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored.
Methods: A well-established fMRI paradigm for studying (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups.
Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences.
Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst non-psychiatric participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus.
Frontiers in behavioral neuroscience
an exploratory fMRI study investigating healthy, depressed and remitted participants
10.3389/fnbeh.2015.00082
1662-5153
Universität Potsdam, Publikationsfonds
PA 2015_04
1142.40
online registration
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-75161">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 271</a>
CC-BY - Namensnennung 4.0 International
Christine Wiebking
Moritz de Greck
Niall W. Duncan
Claus Tempelmann
Malek Bajbouj
Georg Northoff
eng
uncontrolled
major depressive disorder
eng
uncontrolled
interoceptive awareness
eng
uncontrolled
insula
eng
uncontrolled
remission
eng
uncontrolled
neuroimaging
eng
uncontrolled
fMRI
eng
uncontrolled
hopelessness
eng
uncontrolled
interoception
Psychologie
Strukturbereich Kognitionswissenschaften
Referiert
Publikationsfonds der Universität Potsdam
Open Access
7516
2015
eng
14
postprint
1
2015-04-13
--
--
Interoception in insula subregions as a possible state marker for depression
Background: Interoceptive awareness (iA), the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored.
Methods: A well-established fMRI paradigm for studying (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups.
Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences.
Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst non-psychiatric participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus.
an exploratory fMRI study investigating healthy, depressed and remitted participants
urn:nbn:de:kobv:517-opus4-75161
online registration
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/7515">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Christine Wiebking
Moritz de Greck
Niall W. Duncan
Claus Tempelmann
Malek Bajbouj
Georg Northoff
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
271
eng
uncontrolled
major depressive disorder
eng
uncontrolled
interoceptive awareness
eng
uncontrolled
insula
eng
uncontrolled
remission
eng
uncontrolled
neuroimaging
eng
uncontrolled
fMRI
eng
uncontrolled
hopelessness
eng
uncontrolled
interoception
Psychologie
open_access
Strukturbereich Kognitionswissenschaften
Referiert
Open Access
Frontiers
Universität Potsdam
https://publishup.uni-potsdam.de/files/7516/phr271.pdf
https://publishup.uni-potsdam.de/files/7516/phr271.epub
https://publishup.uni-potsdam.de/files/7516/phr271.xml
38728
2015
2015
eng
3204
3212
9
8
36
article
Wiley-Blackwell
Hoboken
1
--
--
--
Increase in glutamate/glutamine concentration in the medial prefrontal cortex during mental imagery: A combined functional mrs and fMRI study
Recent functional magnetic resonance spectroscopy (fMRS) studies have shown changes in glutamate/glutamine (Glx) concentrations between resting-state and active-task conditions. However, the types of task used have been limited to sensory paradigms, and the regions from which Glx concentrations have been measured limited to sensory ones. This leaves open the question as to whether the same effect can be seen in higher-order brain regions during cognitive tasks. Cortical midline structures, especially the medial prefrontal cortex (MPFC), have been suggested to be involved in various such cognitive tasks. We, therefore set out to use fMRS to investigate the dynamics of Glx concentrations in the MPFC between resting-state and mental imagery task conditions. The auditory cortex was used as a control region. In addition, functional magnetic resonance imaging was used to explore task-related neural activity changes. The mental imagery task consisted of imagining swimming and was applied to a large sample of healthy participants (n=46). The participants were all competitive swimmers, ensuring proficiency in mental-swimming. Glx concentrations in the MPFC increased during the imagery task, as compared to resting-state periods preceding and following the task. These increases mirror BOLD activity changes in the same region during the task. No changes in either Glx concentrations or BOLD activity were seen in the auditory cortex. These findings contribute to our understanding of the biochemical basis of generating or manipulating mental representations and the MPFC's role in this. Hum Brain Mapp 36:3204-3212, 2015. (c) 2015 Wiley Periodicals, Inc.
Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging
10.1002/hbm.22841
26059006
1065-9471
1097-0193
wos:2015
WOS:000357949900026
Huang, ZR (reprint author), Univ Ottawa, Mental Hlth Res Inst, Room 6440,1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada., Dr.zirui.huang@gmail.com
Swim Canada; CIHR; HDRF-ISAN; EJLB-CIHR
Zirui Huang
Henry (Hap) Davis Iv
Qiang Yue
Christine Wiebking
Niall W. Duncan
Jianfeng Zhang
Nils-Frederic Wagner
Annemarie Wolff
Georg Northoff
eng
uncontrolled
medial prefrontal cortex
eng
uncontrolled
glutamate
eng
uncontrolled
glutamine
eng
uncontrolled
magnetic resonance spectroscopy
eng
uncontrolled
functional magnetic resonance imaging
eng
uncontrolled
mental imagery
Referiert
Department Sport- und Gesundheitswissenschaften
Institut für Sportwissenschaft