7515
2015
2015
eng
14
9
article
Frontiers Research Foundation
Lausanne
1
2015-04-13
2015-04-10
--
Interoception in insula subregions as a possible state marker for depression
Background: Interoceptive awareness (iA), the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored.
Methods: A well-established fMRI paradigm for studying (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups.
Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences.
Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst non-psychiatric participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus.
Frontiers in behavioral neuroscience
an exploratory fMRI study investigating healthy, depressed and remitted participants
10.3389/fnbeh.2015.00082
1662-5153
Universität Potsdam, Publikationsfonds
PA 2015_04
1142.40
online registration
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-75161">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 271</a>
CC-BY - Namensnennung 4.0 International
Christine Wiebking
Moritz de Greck
Niall W. Duncan
Claus Tempelmann
Malek Bajbouj
Georg Northoff
eng
uncontrolled
major depressive disorder
eng
uncontrolled
interoceptive awareness
eng
uncontrolled
insula
eng
uncontrolled
remission
eng
uncontrolled
neuroimaging
eng
uncontrolled
fMRI
eng
uncontrolled
hopelessness
eng
uncontrolled
interoception
Psychologie
Strukturbereich Kognitionswissenschaften
Referiert
Publikationsfonds der Universität Potsdam
Open Access
7516
2015
eng
14
postprint
1
2015-04-13
--
--
Interoception in insula subregions as a possible state marker for depression
Background: Interoceptive awareness (iA), the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored.
Methods: A well-established fMRI paradigm for studying (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups.
Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences.
Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst non-psychiatric participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus.
an exploratory fMRI study investigating healthy, depressed and remitted participants
urn:nbn:de:kobv:517-opus4-75161
online registration
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/7515">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Christine Wiebking
Moritz de Greck
Niall W. Duncan
Claus Tempelmann
Malek Bajbouj
Georg Northoff
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
271
eng
uncontrolled
major depressive disorder
eng
uncontrolled
interoceptive awareness
eng
uncontrolled
insula
eng
uncontrolled
remission
eng
uncontrolled
neuroimaging
eng
uncontrolled
fMRI
eng
uncontrolled
hopelessness
eng
uncontrolled
interoception
Psychologie
open_access
Strukturbereich Kognitionswissenschaften
Referiert
Open Access
Frontiers
Universität Potsdam
https://publishup.uni-potsdam.de/files/7516/phr271.pdf
https://publishup.uni-potsdam.de/files/7516/phr271.epub
https://publishup.uni-potsdam.de/files/7516/phr271.xml