36793
2011
2011
eng
176
178
3
2
4
article
Elsevier
Amsterdam
1
--
--
--
Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea
The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.
Phytochemistry letters
10.1016/j.phytol.2011.02.010
1874-3900
wos:2011-2013
WOS:000290788100027
Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya., ayenesew@uonbi.ac.ke
Deutche Forschungemeinschaft (DFG), Germany; Germany Federal Ministry
for Economic Cooperation and Development (BMZ) within the DFG/BMZ
Wanyama P. Juma
Hoseah M. Akala
Fredrick L. Eyase
Lois M. Muiva
Matthias Heydenreich
Faith A. Okalebo
Peter M. Gitu
Martin G. Peter
Douglas S. Walsh
Mabel Imbuga
Abiy Yenesew
eng
uncontrolled
Tephrosia purpurea
eng
uncontrolled
Leguminosae
eng
uncontrolled
Stem
eng
uncontrolled
Flavone
eng
uncontrolled
Terpurinflavone
eng
uncontrolled
Antiplasmodial
Institut für Chemie
Referiert
31371
2006
2006
eng
article
1
--
--
--
Antiplasmodial flavonoids from Erythrina sacleuxii
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence
http://www.thieme-connect.com/ejournals/toc/plantamedica
10.1055/s-2005-873200
0032-0943
allegro:1991-2014
10102125
Planta medica. - ISSN 0032-0943. - 72 (2006), 2, S. 187 - 189
Andrew W. Andayi
Abiy Yenesew
Solomon Derese
Jacob O. Midiwo
Peter M. Gitu
Ogoche J. I. Jondiko
Hoseah M. Akala
Pamela Liyala
Julia Wangui
Norman C. Waters
Matthias Heydenreich
Martin G. Peter
Institut für Chemie
Referiert
30861
2009
2009
eng
article
1
--
--
--
8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica
A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone ext. of the root bark of Erythrina abyssinica. In addn., the known isoflavonoid derivs. eryvarin L, erycristagallin and shinpterocarpin were identified for the first time from the roots of this plant. The structures were detd. on the basis of spectroscopic evidence. The new compd. showed selective antimicrobial activity against Trichophyton mentagrophytes. The acetone ext. of the root bark of E. abyssinica showed radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the std. quercetin. [on SciFinder (R)]
http://www.ajol.info/journal_index.php?jid=120&ab=bcse
1011-3924
allegro:1991-2014
10106611
Bulletin of The Chemical Society of Ethiopia. - ISSN 1011-3924. - 23 (2009), 2, S. 205 - 210
Abiy Yenesew
Hannington Twinomuhwezi
Bernard T. Kiremire
Martin N. Mbugua
Peter M. Gitu
Matthias Heydenreich
Martin G. Peter
Institut für Chemie
Referiert