47328
2019
2019
eng
14
841
postprint
1
2019-08-08
2019-08-08
--
Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers
In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
Behavioral, Neural and Polygenic Correlates
1866-8364
10.25932/publishup-47328
urn:nbn:de:kobv:517-opus4-473280
online registration
Garbusow, Maria
Verion of record
<a href="https://publishup.uni-potsdam.de/48724">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Journal of Clinical Medicine 8 (2019) 8 DOI: 10.3390/jcm8081188
CC-BY - Namensnennung 4.0 International
Maria Garbusow
Stephan Nebe
Christian Sommer
Sören Kuitunen-Paul
Miriam Hannah Sebold
Daniel Schad
Eva Friedel
Ilya M. Veer
Hans-Ulrich Wittchen
Michael Armin Rapp
Stephan Ripke
Henrik Walter
Quentin J. M. Huys
Florian Schlagenhauf
Michael N. Smolka
Andreas Heinz
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
841
eng
uncontrolled
Pavlovian-to-instrumental transfer
eng
uncontrolled
amygdala
eng
uncontrolled
alcohol
eng
uncontrolled
polygenic risk
eng
uncontrolled
high risk drinkers
Psychologie
open_access
Referiert
Department Sport- und Gesundheitswissenschaften
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/47328/zhr841.pdf
48547
2019
2019
eng
2437
2449
13
8
236
article
Springer
New York
1
--
2019-06-28
--
Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms
Background Aversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover, the underlying computational mechanisms of these decision-making biases are unknown. Methods To elucidate these mechanisms, 54 healthy young male subjects performed a two-step sequential decision-making task, which allows to computationally model different aspects of learning, e.g., model-free, habitual, and model-based, goal-directed learning. We used a within-subject design, crossing task valence (reward vs. punishment learning) with emotional context (aversive vs. neutral background stimuli). We analyzed choice data, applied a computational model, and performed simulations. Results Whereas model-based learning was not affected, aversive stimuli interacted with model-free learning in a way that depended on task valence. Thus, aversive stimuli increased model-free avoidance learning but decreased model-free reward learning. The computational model confirmed this effect: the parameter lambda that indicates the influence of reward prediction errors on decision values was increased in the punishment condition but decreased in the reward condition when aversive stimuli were present. Further, by using the inferred computational parameters to simulate choice data, our effects were captured. Exploratory analyses revealed that the observed biases were associated with subclinical depressive symptoms. Conclusion Our data show that aversive environmental stimuli affect complex learning and decision-making, which depends on task valence. Further, we provide a model of the underlying computations of this affective modulation. Finally, our finding of increased decision-making biases in subjects reporting subclinical depressive symptoms matches recent reports of amplified Pavlovian influences on action selection in depression and suggests a potential vulnerability factor for mood disorders. We discuss our findings in the light of the involvement of the neuromodulators serotonin and dopamine.
Psychopharmacology
10.1007/s00213-019-05299-9
31254091
0033-3158
1432-2072
wos:2019
WOS:000481767900012
Sebold, M (reprint author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany.; Sebold, M (reprint author), Univ Potsdam, Dept Social & Prevent Med, Potsdam, Germany., miriam.sebold@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [HE2597/14-1, HE2597/14-2, RA1047/2-1, RA1047/2-2, RO 5046/2-2, SCHA1971/1-2, SCHL 1969/4-1, SCHL 1969/2-2]; Federal Ministry of Health (Bundesministerium fur Gesundheit, BMG) [ZMVI1-2516DSM223]
2020-12-07T18:28:11+00:00
sword
importub
filename=package.tar
303d8df5662341f99b5ffb6ed8264076
false
true
Miriam Hannah Sebold
Maria Garbusow
P. Jetzschmann
Daniel Schad
S. Nebe
Florian Schlagenhauf
A. Heinz
Michael Armin Rapp
Nina Romanczuk-Seiferth
eng
uncontrolled
Reward learning
eng
uncontrolled
Avoidance learning
eng
uncontrolled
Reinforcement learning
eng
uncontrolled
Computational psychiatry
eng
uncontrolled
Decision-making
eng
uncontrolled
Affective modulation
eng
uncontrolled
Depression symptoms
Psychologie
Department Sport- und Gesundheitswissenschaften
Import
48724
2019
2019
eng
14
8
8
article
MDPI
Basel
1
2019-08-08
2019-08-08
--
Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers
In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
Journal of Clinical Medicine
Behavioral, Neural and Polygenic Correlates
10.3390/jcm8081188
2077-0383
31398853
wos:2019
1188
WOS:000483737700173
Garbusow, M (reprint author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany.; Garbusow, M (reprint author), Berlin Inst Hlth, D-10117 Berlin, Germany., maria.garbusow@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [FOR 1617, FR 3572/1-1, HE 2597/13-1, HE 2597/13-2, HE 2597/15-1, HE 2597/15-2, RA 1047/2-1, SCHL 1969/2-2/4-1, SM 80/7-1, SM 80/7-2, WA 1539/7-1, WI 709/10-1, WI 709/10-2, SFB 940/1, SFB 940/2]; Charite-Universitatsmedizin; Berlin Institute of Health
2020-12-18T14:21:37+00:00
sword
importub
filename=package.tar
60fb3b29192282dfe5f64cc1f96a7169
Garbusow, Maria
<a href="https://doi.org/10.25932/publishup-47328">Zweitveröffentlichung in der Schriftenreihe Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe ; 841</a>
CC-BY - Namensnennung 4.0 International
Maria Garbusow
Stephan Nebe
Christian Sommer
Sören Kuitunen-Paul
Miriam Hannah Sebold
Daniel Schad
Eva Friedel
Ilya M. Veer
Hans-Ulrich Wittchen
Michael Armin Rapp
Stephan Ripke
Henrik Walter
Quentin J. M. Huys
Florian Schlagenhauf
Michael N. Smolka
Andreas Heinz
eng
uncontrolled
Pavlovian-to-instrumental transfer
eng
uncontrolled
amygdala
eng
uncontrolled
alcohol
eng
uncontrolled
polygenic risk
eng
uncontrolled
high risk drinkers
Psychologie
Referiert
Department Sport- und Gesundheitswissenschaften
Import
Gold Open-Access
DOAJ gelistet
52809
2018
2018
eng
128A
128A
1
42
other
Wiley
Hoboken
1
--
--
--
Multi-level evidence of general pavlovian-to-instrumental transfer in alcohol use disorder
Alcoholism : clinical and experimental research ; the official journal of the American Medical Society on Alcoholism and the Research Society on Alcoholism
0145-6008
1530-0277
wos:2018
41st Annual Scientific Meeting of the Research-Society-on-Alcoholism
JUN 16-20, 2018
WOS:000443221501437
San Diego, CA
2021-11-24T12:39:34+00:00
sword
importub
filename=package.tar
b9ac3aed74f9496127d45fec3981b970
false
true
Maria Garbusow
Christian Sommer
Stephan Nebe
Miriam Hannah Sebold
Sören Kuitunen-Paul
Hans-Ulrich Wittchen
Michael N. Smolka
Ulrich S. Zimmermann
Michael Armin Rapp
Quentin J. M. Huys
Florian Schlagenhauf
Andreas Heinz
Medizin und Gesundheit
Department Sport- und Gesundheitswissenschaften
Import
53471
2018
2018
eng
S546
S546
1
48
other
Elsevier
ISSY-LES-MOULINEAUX
1
--
--
--
Pavlovian-instrumental transfer in the course of alcohol use disorder
Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping on- going thought and behavior. The influence of Pavlovian stimuli on on-going behavior is paradigmatically measured by Pavlovian-to-instrumental-transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol
dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent, and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced Pavlovian-Instrumental transfer.
Methods: 32 recently detoxified alcohol-dependent patients and 32 age and gender matched healthy controls performed a PIT task with instrumental go/no-go approach behaviours. The task involved both Pavlovian stimuli associated with monetary rewards and losses, and images of drinks.
Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs.
Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol- dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.
European psychiatry : the journal of the Association of European Psychiatrists
0924-9338
1778-3585
wos:2018
WOS:000461256107116
2022-01-17T13:35:26+00:00
sword
importub
filename=package.tar
35a271d1eb0584101215ef2a32edd3bc
Garbusow, Maria
false
true
Maria Garbusow
C. Sommer
S. Nebe
Miriam Hannah Sebold
Sören Kuitunen-Paul
H. U. Wittchen
M. Smolka
U. Zimmermann
Michael Armin Rapp
Q. Huys
Florian Schlagenhauf
A. Heinz
Medizin und Gesundheit
Referiert
Department Psychologie
Import
DOAJ gelistet
53472
2018
2018
eng
S274
S274
1
48
other
Elsevier
Paris
1
--
--
--
From goals to habits in alcohol dependence
European psychiatry : the journal of the Association of European Psychiatrists
association with treatment outcome and cognitive bias modification training
0924-9338
1778-3585
wos:2018
WOS:000461256103156
2022-01-17T14:23:22+00:00
sword
importub
filename=package.tar
925f92fd18f2630bd4c9ebdc9000f0a1
false
true
Miriam Hannah Sebold
Maria Garbusow
S. Nebe
L. Sundmacher
Sören Kuitunen-Paul
H. U. Wittchen
M. Smolka
U. Zimmermann
Michael Armin Rapp
Q. Huys
Florian Schlagenhauf
A. Heinz
Psychologie
Referiert
Department Psychologie
Import
DOAJ gelistet
49914
2018
2018
eng
295
308
14
3
269
article
Springer
Heidelberg
1
2018-01-08
2018-01-08
--
Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk
The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = -3.86, p < .001), but not in healthy controls (t = -0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t((30)) = 2.06, p < .05). Interestingly, both the effects were only present in subsequent abstainers, but not relapsers and in those with mild but not severe dependence. Our data show that alcohol-related cues can acquire inhibitory behavioral features typical of aversive stimuli despite being accompanied by a stronger NAcc activation, suggesting salience attribution. The fact that these findings are restricted to abstinence and milder illness suggests that they may be potential resilience factors.
European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
10.1007/s00406-017-0860-4
29313106
0940-1334
1433-8491
wos:2019
WOS:000464862700004
Smolka, MN (reprint author), Tech Univ Dresden, Dept Psychiat, Dresden, Germany.; Smolka, MN (reprint author), Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany., michael.rapp@uni-potsdam.de
German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [FOR 1617, HE 2597/13-1, HE 2597/13-2, HE 2597/14-1, HE 2597/14-2, HE 2597/15-1, HE 2597/15-2, RA 1047/2-1, RA 1047/2-2, SCHA 1971/1-2, SCHL 1969/2-1, SCHL 1969/2-2, SM 80/7-1, SM 80/7-2, WI 709/10-1, WI 709/10-2, ZI 1119/3-1, ZI 1119/3-2]; Charite-Universitatsmedizin; Berlin Institute of Health
2021-03-15T06:16:44+00:00
sword
importub
filename=package.tar
dcdd8cee01eb32a748d4d9e53da92b7c
Rapp, Michael Armin
false
true
Daniel Schad
Maria Garbusow
Eva Friedel
Christian Sommer
Miriam Hannah Sebold
Claudia Hägele
Nadine Bernhardt
Stephan Nebe
Sören Kuitunen-Paul
Shuyan Liu
Uta Eichmann
Anne Beck
Hans-Ulrich Wittchen
Henrik Walter
Philipp Sterzer
Ulrich S. Zimmermann
Michael N. Smolka
Florian Schlagenhauf
Quentin J. M. Huys
Andreas Heinz
Michael Armin Rapp
eng
uncontrolled
Alcohol dependence
eng
uncontrolled
Human neuroimaging
eng
uncontrolled
Nucleus accumbens
eng
uncontrolled
Pavlovian-instrumental transfer
eng
uncontrolled
Relapse
Medizin und Gesundheit
Referiert
Department Sport- und Gesundheitswissenschaften
Import
46735
2017
2017
eng
S11
S11
1
41
other
Elsevier
Paris
1
--
--
--
Neurobiological correlates of learning and decision-making in alcohol dependence
European psychiatry : the journal of the Association of European Psychiatrists
10.1016/j.eurpsy.2017.01.084
0924-9338
1778-3585
wos:2017
WOS:000404952200025
importub
2020-04-20T03:57:01+00:00
filename=package.tar
5e7278e8b5b17093fecc96789207bb0e
Miriam Hannah Sebold
Stephan Nebe
Maria Garbusow
Daniel Schad
Christian Sommer
Michael Armin Rapp
Michael N. Smolka
Quentin J. M. Huys
Florian Schlagenhauf
Andreas Heinz
Referiert
Department Sport- und Gesundheitswissenschaften
Import
Institut für Sportmedizin und Prävention
46153
2017
2017
eng
847
856
10
82
article
Elsevier
New York
1
--
--
--
When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence
BACKGROUND: Addiction is supposedly characterized by a shift from goal-directed to habitual decision making, thus facilitating automatic drug intake. The two-step task allows distinguishing between these mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-free control. In addicted patients, decision making may also strongly depend upon drug-associated expectations. Therefore, we investigated model-based versus model-free decision making and its neural correlates as well as alcohol expectancies in alcohol-dependent patients and healthy controls and assessed treatment outcome in patients. METHODS: Ninety detoxified, medication-free, alcohol-dependent patients and 96 age-and gender-matched control subjects underwent functional magnetic resonance imaging during the two-step task. Alcohol expectancies were measured with the Alcohol Expectancy Questionnaire. Over a follow-up period of 48 weeks, 37 patients remained abstinent and 53 patients relapsed as indicated by the Alcohol Timeline Followback method. RESULTS: Patients who relapsed displayed reduced medial prefrontal cortex activation during model-based decision making. Furthermore, high alcohol expectancies were associated with low model-based control in relapsers, while the opposite was observed in abstainers and healthy control subjects. However, reduced model-based control per se was not associated with subsequent relapse. CONCLUSIONS: These findings suggest that poor treatment outcome in alcohol dependence does not simply result from a shift from model-based to model-free control but is instead dependent on the interaction between high drug expectancies and low model-based decision making. Reduced model-based medial prefrontal cortex signatures in those who relapse point to a neural correlate of relapse risk. These observations suggest that therapeutic interventions should target subjective alcohol expectancies.
Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry
10.1016/j.biopsych.2017.04.019
28673442
0006-3223
1873-2402
wos:2017
WOS:000414057400012
Sebold, M (reprint author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany., miriam.sebold@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft Forschergruppe) [HE2597/14-1, HE2597/14-2, RA1047/2-1, RA1047/2-2, SM 80/7-1, SM 80/7-2, ZI1119/3-1, ZI1119/3-2, 1617]
importub
2020-04-19T23:06:01+00:00
filename=package.tar
df0d039485f2cf3078c586e3186b8cc6
Miriam Hannah Sebold
Stephan Nebe
Maria Garbusow
Matthias Guggenmos
Daniel Schad
Anne Beck
Sören Kuitunen-Paul
Christian Sommer
Robin Frank
Peter Neu
Ulrich S. Zimmermann
Michael Armin Rapp
Michael N. Smolka
Quentin J. M. Huys
Florian Schlagenhauf
Andreas Heinz
eng
uncontrolled
Alcohol dependence
eng
uncontrolled
Alcohol expectancy
eng
uncontrolled
Goal-directed control
eng
uncontrolled
Medial prefrontal cortex
eng
uncontrolled
Reinforcement learning
eng
uncontrolled
Treatment outcome
Referiert
Department Sport- und Gesundheitswissenschaften
Import
Institut für Sportmedizin und Prävention
45385
2016
2016
eng
719
731
13
21
article
Wiley-Blackwell
Hoboken
1
--
--
--
Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence
In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n=31 detoxified patients diagnosed with alcohol dependence and n=24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence.
Addiction biology
10.1111/adb.12243
25828702
1355-6215
1369-1600
wos2016:2019
WOS:000374486200017
Garbusow, M (reprint author), Charite, Dept Clin Psychiat & Psychotherapy, Campus Mitte, Charitepl 1, D-10117 Berlin, Germany., maria.garbusow@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) [FOR 1617, HE 2597/13-1, HE 2597/14-1, HE 2597/15-1, SCHL 1969/2-1, SM 80/7-1, STE 1430/6-1, RA 1047/2-1, WI 709/10-1, ZI 1119/3-1]; German Research Foundation (NeuroCure) [EXC 257]; Netherlands Organisation for Healthy Research and Development [AGIKO 92003576]
importub
2020-03-22T18:06:01+00:00
filename=package.tar
2039d75849d8ed914592b7c85b581306
Maria Garbusow
Daniel Schad
Miriam Hannah Sebold
Eva Friedel
Nadine Bernhardt
Stefan P. Koch
Bruno Steinacher
Norbert Kathmann
Dirk E. M. Geurts
Christian Sommer
Dirk K. Mueller
Stephan Nebe
Soeren Paul
Hans-Ulrich Wittchen
Ulrich S. Zimmermann
Henrik Walter
Michael N. Smolka
Philipp Sterzer
Michael Armin Rapp
Quentin J. M. Huys
Florian Schlagenhauf
Andreas Heinz
eng
uncontrolled
human Pavlovian-to-instrumental transfer
eng
uncontrolled
nucleus accumbens
eng
uncontrolled
relapse in alcohol use disorder
Referiert
Exzellenzbereich Kognitionswissenschaften
Import
38218
2014
2014
eng
111
121
11
2
70
article
Karger
Basel
1
--
--
--
Pavlovian-to-instrumental transfer in alcohol dependence: a pilot study
Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping ongoing thought and behavior. The influence of pavlovian stimuli on ongoing behavior is paradigmatically measured by pavlovian-to-instrumental transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced PIT. Methods: Thirty-two recently detoxified alcohol-dependent patients and 32 age- and gender-matched healthy controls performed a PIT task with instrumental go/no-go approach behaviors. The task involved both pavlovian stimuli associated with monetary rewards and losses, and images of drinks. Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect, and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs. Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol-dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.
Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography
10.1159/000363507
25359491
0302-282X
1423-0224
wos:2014
WOS:000343956100006
Garbusow, M (reprint author), Charite, Charite Campus Mitte, Dept Psychiat & Psychotherapy, Charitepl 1, DE-10117 Berlin, Germany., maria.garbusow@charite.de
German Research Foundation (Deutsche Forschungsgemeinschaft)
[HE2597/14-1, SM80/7-1, RA1047/2-1]
Maria Garbusow
Daniel Schad
Christian Sommer
Elisabeth Juenger
Miriam Hannah Sebold
Eva Friedel
Jean Wendt
Norbert Kathmann
Florian Schlagenhauf
Ulrich S. Zimmermann
Andreas Heinz
Quentin J. M. Huys
Michael Armin Rapp
eng
uncontrolled
Pavlovian-to-instrumental transfer
eng
uncontrolled
Alcohol dependence
eng
uncontrolled
Human
Referiert
Department Psychologie
Institut für Psychologie
38219
2014
2014
eng
122
131
10
2
70
article
Karger
Basel
1
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Model-based and model-free decisions in alcohol dependence
Background: Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive. Methods: Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns. Results: Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task. Conclusion: Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex.
Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography
10.1159/000362840
25359492
0302-282X
1423-0224
wos:2014
WOS:000343956100007
Sebold, M (reprint author), Charite, Campus Charite Mitte, Dept Psychiat & Psychotherapy, Charitepl 1, DE-10117 Berlin, Germany., Miriam.sebold@charite.de
German Research Foundation (DeutscheForschungsgemeinschaft)
[HE2597/14-1, ZI1119/3-1, DFG RA1047/2-1]
Miriam Hannah Sebold
Lorenz Deserno
Stefan Nebe
Daniel Schad
Maria Garbusow
Claudia Haegele
Juergen Keller
Elisabeth Juenger
Norbert Kathmann
Michael N. Smolka
Michael Armin Rapp
Florian Schlagenhauf
Andreas Heinz
Quentin J. M. Huys
eng
uncontrolled
Alcohol dependence
eng
uncontrolled
Decision-making
eng
uncontrolled
Reinforcement learning
eng
uncontrolled
Dopamine
eng
uncontrolled
Computational psychiatry
Referiert
Department Psychologie
Institut für Psychologie