37145
2011
2011
eng
1
33
33
1
240
review
Springer
Berlin
1
--
--
--
Smart polymer surfaces concepts and applications in biosciences
Stimuli-responsive macromolecules (i.e., pH-, thermo-, photo-, chemo-, and bioresponsive polymers) have gained exponential importance in materials science, nanotechnology, and biotechnology during the last two decades. This chapter describes the usefulness of this class of polymer for preparing smart surfaces (e.g., modified planar surfaces, particles surfaces, and surfaces of three-dimensional scaffolds). Some efficient pathways for connecting these macromolecules to inorganic, polymer, or biological substrates are described. In addition, some emerging bioapplications of smart polymer surfaces (e.g., antifouling surfaces, cell engineering, protein chromatography, tissue engineering, biochips, and bioassays) are critically discussed.
Advances in polymer science = Fortschritte der Hochpolymeren-Forschung
Advances in Polymer Science
10.1007/12_2010_88
978-3-642-20154-7
0065-3195
wos:2011-2013
WOS:000293033800001
Lutz, JF (reprint author), Fraunhofer Inst Appl Polymer Res, Geiselbergstr 69, D-14476 Potsdam, Germany., erik.wischerhoff@iap.fraunhofer.de; nezhabadi@yahoo.fr; andre.laschewsky@iap.fraunhofer.de; lutz@iap.fhg.de; lutz@iap.fhg.de
Erik Wischerhoff
Nezha Badi
André Laschewsky
Jean-Francois Lutz
eng
uncontrolled
Antifouling surfaces
eng
uncontrolled
Bioactive surfaces
eng
uncontrolled
Biocompatible polymers
eng
uncontrolled
Bioseparation
eng
uncontrolled
Cell engineering
eng
uncontrolled
Polymer-modified surfaces
eng
uncontrolled
Stimuli-responsive polymers
Institut für Chemie
Referiert
36209
2012
2012
eng
185
190
6
3
10
article
Wichtig
Milano
1
--
--
--
Synthesis and characterization of telechelic oligoethers with terminal cinnamylidene acetic acid moieties
Purpose: The formation of photoresponsive hydrogels were reported by irradiation of star-shaped poly(ethylene glycol)s with terminal cinnamylidene acetic acid (CAA) groups, which are capable of a photoinduced [2+2] cycloaddition. In this study we explored whether oligo(ethylene glycol) s and oligo(propylene glycol)s of varying molecular architecture (linear or star-shaped) or molecular weights could be functionalized with CAA as terminal groups by esterification or by amide formation.
Methods: Oligo(ethylene glycol) (OEG) and oligo(propylene glycol) (OPG) with varying molecular architecture (linear, star-shaped) and weight average molecular weights between 1000 and 5000 g.mol(-1) were functionalized by means of esterification of hydroxyl or amine endgroups with cinnamylidene acetic acid (CAA) or cinnamylidene acetyl chloride (CAC) as telechelic endgroups. The chemical structure, thermal properties, and molecular weights of the oligoethers obtained were determined by NMR spectroscopy, UV spectroscopy, DSC, and MALDI-TOF.
Results: CAA-functionalized linear and star-shaped OEGs or OPGs could be obtained with a degree of functionalization higher than 90%. In MALDI-TOF measurements an increase in Mw of about 150 g.mol(-1) (for each terminal end) after the functionalization reaction was observed. OEGCAA and OPGCAA showed an increase in glass transition temperature (T-g) from about -70 degrees C to -50 degrees C, compared to the unfunctionalized oligoethers. In addition, the melting temperature (T-m) of OEGCAA decreased from about 55 C to 30 degrees C, which can be accounted for by the hampered crystallization of the precursors because of the bulky CAA end groups as well as by the loss of the hydroxyl telechelic end groups.
Conclusion: The synthesis of photoresponsive oligoethers containing cinnamylidene acetic acid as telechelic endgroup was reported and high degrees of functionalization could be achieved. Such photosensitive oligomers are promising candidates as reactive precursors, for the preparation of biocompatible high molecular weight polymers and polymer networks.
Journal of applied biomaterials & functional materials
10.5301/JABFM.2012.10364
2280-8000
wos:2011-2013
WOS:000324537200004
Lendlein, A (reprint author), Helmholtz Zentrum Geesthacht, Ctr Biomat Dev, Kantstr 55, D-14513 Teltow, Germany., andreas.lendlein@hzg.de
Helmholtz Association
Christian Melchert
Nunnarpas Yongvongsoontorn
Marc Behl
Andreas Lendlein
eng
uncontrolled
Biocompatible polymers
eng
uncontrolled
Cinnamylidene acetic acid
eng
uncontrolled
Photoresponsive polymers
Institut für Chemie
Referiert