41925
2018
2018
eng
12
473
postprint
1
2018-11-12
2018-11-12
--
Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level
Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult) targets produced larger P3b (but not P3a) amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation) increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
A Pilot Study
urn:nbn:de:kobv:517-opus4-419259
online registration
202
Frontiers in Human Neuroscience 12 (2018) Art. 202 DOI: 10.3389/fnhum.2018.00202
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/41926">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Carlos Ventura-Bort
Janine Wirkner
Hannah Genheimer
Julia Wendt
Alfons O. Hamm
Mathias Weymar
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
473
eng
uncontrolled
EEG
eng
uncontrolled
P300
eng
uncontrolled
tVNS
eng
uncontrolled
norepinephrine
eng
uncontrolled
locus coeruleus
eng
uncontrolled
salivary alpha-amylase
Medizin und Gesundheit
open_access
Referiert
Open Access
Department Psychologie
Institut für Psychologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/41925/phr473.online.pdf
41926
2018
2018
eng
1
12
12
article
Frontiers Research Foundation
Lausanne
1
2018-06-21
2018-06-21
--
Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level
Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory post hoc analyses, however, revealed that, in comparison to standard stimuli, easy (but not difficult) targets produced larger P3b (but not P3a) amplitudes during active tVNS, compared to sham stimulation. For sAA levels, although main analyses did not show differential effects of stimulation, direct testing revealed that tVNS (but not sham stimulation) increased sAA levels after stimulation. Additionally, larger differences between tVNS and sham stimulation in P3b magnitudes for easy targets were associated with larger increase in sAA levels after tVNS, but not after sham stimulation. Despite preliminary evidence for a modulatory influence of tVNS on the P3b, which may be partly mediated by activation of the noradrenergic system, additional research in this field is clearly warranted. Future studies need to clarify whether tVNS also facilitates other processes, such as learning and memory, and whether tVNS can be used as therapeutic tool.
Frontiers in Human Neuroscience
A Pilot Study
10.3389/fnhum.2018.00202
1662-5161
Universität Potsdam, Publikationsfonds
PA 2018_26
1995.09
online registration
202
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-419259">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 473</a>
CC-BY - Namensnennung 4.0 International
Carlos Ventura-Bort
Janine Wirkner
Hannah Genheimer
Julia Wendt
Alfons O. Hamm
Mathias Weymar
eng
uncontrolled
EEG
eng
uncontrolled
P300
eng
uncontrolled
tVNS
eng
uncontrolled
norepinephrine
eng
uncontrolled
locus coeruleus
eng
uncontrolled
salivary alpha-amylase
Medizin und Gesundheit
open_access
Referiert
Publikationsfonds der Universität Potsdam
Open Access
Department Psychologie
Institut für Psychologie