Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-15418 Wissenschaftlicher Artikel Yenesew, Abiy; Induli, M.; Derese, Solomon; Midiwo, Jacob O.; Heydenreich, Matthias; Peter, Martin G.; Akala, Hoseah M.; Wangui, Julia; Liyala, Pamela; Waters, Norman C. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 +/- 1.1 and 5.3 +/- 0.7 mug/ml, respectively. From this extract, a new chalcone, 2,3,4,4'-tetrahydroxy-5- prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'- prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti- plasmodial principles. The structures were determined on the basis of spectroscopic evidence. (C) 2004 Elsevier Ltd. All rights reserved 2004 Institut für Chemie OPUS4-31371 Wissenschaftlicher Artikel Andayi, Andrew W.; Yenesew, Abiy; Derese, Solomon; Midiwo, Jacob O.; Gitu, Peter M.; Jondiko, Ogoche J. I.; Akala, Hoseah M.; Liyala, Pamela; Wangui, Julia; Waters, Norman C.; Heydenreich, Matthias; Peter, Martin G. Antiplasmodial flavonoids from Erythrina sacleuxii The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence 2006 10.1055/s-2005-873200 Institut für Chemie