@article{MatternPudellLaskinetal.2021,
  author    = {Mattern, Maximilian and Pudell, Jan-Etienne and Laskin, Gennadii and Reppert, Alexander von and Bargheer, Matias},
  title     = {Analysis of the temperature- and fluence-dependent magnetic stress in laser-excited SrRuO3},
  series = {Structural dynamics},
  volume    = {8},
  journal   = {Structural dynamics},
  number    = {2},
  publisher = {AIP Publishing LLC},
  address   = {Melville, NY},
  issn      = {2329-7778},
  doi       = {10.1063/4.0000072},
  pages     = {9},
  year      = {2021},
  abstract  = {We use ultrafast x-ray diffraction to investigate the effect of expansive phononic and contractive magnetic stress driving the picosecond strain response of a metallic perovskite SrRuO3 thin film upon femtosecond laser excitation. We exemplify how the anisotropic bulk equilibrium thermal expansion can be used to predict the response of the thin film to ultrafast deposition of energy. It is key to consider that the laterally homogeneous laser excitation changes the strain response compared to the near-equilibrium thermal expansion because the balanced in-plane stresses suppress the Poisson stress on the picosecond timescale. We find a very large negative Gr{\"u}neisen constant describing the large contractive stress imposed by a small amount of energy in the spin system. The temperature and fluence dependence of the strain response for a double-pulse excitation scheme demonstrates the saturation of the magnetic stress in the high-fluence regime.},
  language  = {en}
}
@article{KocPetrowThieken2020,
  author    = {Koc, Gamze and Petrow, Theresia and Thieken, Annegret},
  title     = {Analysis of the most severe flood events in Turkey (1960-2014)},
  series = {Water / Molecular Diversity Preservation International (MDPI)},
  volume    = {12},
  journal   = {Water / Molecular Diversity Preservation International (MDPI)},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4441},
  doi       = {10.3390/w12061562},
  pages     = {32},
  year      = {2020},
  abstract  = {The most severe flood events in Turkey were determined for the period 1960-2014 by considering the number of fatalities, the number of affected people, and the total economic losses as indicators. The potential triggering mechanisms (i.e., atmospheric circulations and precipitation amounts) and aggravating pathways (i.e., topographic features, catchment size, land use types, and soil properties) of these 25 events were analyzed. On this basis, a new approach was developed to identify the main influencing factor per event and to provide additional information for determining the dominant flood occurrence pathways for severe floods. The events were then classified through hierarchical cluster analysis. As a result, six different clusters were found and characterized. Cluster 1 comprised flood events that were mainly influenced by drainage characteristics (e.g., catchment size and shape); Cluster 2 comprised events aggravated predominantly by urbanization; steep topography was identified to be the dominant factor for Cluster 3; extreme rainfall was determined as the main triggering factor for Cluster 4; saturated soil conditions were found to be the dominant factor for Cluster 5; and orographic effects of mountain ranges characterized Cluster 6. This study determined pathway patterns of the severe floods in Turkey with regard to their main causal or aggravating mechanisms. Accordingly, geomorphological properties are of major importance in large catchments in eastern and northeastern Anatolia. In addition, in small catchments, the share of urbanized area seems to be an important factor for the extent of flood impacts. This paper presents an outcome that could be used for future urban planning and flood risk prevention studies to understand the flood mechanisms in different regions of Turkey.},
  language  = {en}
}
@article{ArkesAbereggArpin2022,
  author    = {Arkes, Hal R. and Aberegg, Scott K. and Arpin, Kevin A.},
  title     = {Analysis of physicians' probability estimates of a medical outcome based on a sequence of events},
  series = {JAMA network open / American Medical Association},
  volume    = {5},
  journal   = {JAMA network open / American Medical Association},
  number    = {6},
  publisher = {American Veterinary Medical Association},
  address   = {Chicago},
  issn      = {2574-3805},
  doi       = {10.1001/jamanetworkopen.2022.18804},
  pages     = {10},
  year      = {2022},
  abstract  = {IMPORTANCE The probability of a conjunction of 2 independent events is the product of the probabilities of the 2 components and therefore cannot exceed the probability of either component; violation of this basic law is called the conjunction fallacy. A common medical decision-making scenario involves estimating the probability of a final outcome resulting from a sequence of independent events; however, little is known about physicians' ability to accurately estimate the overall probability of success in these situations. OBJECTIVE To ascertain whether physicians are able to correctly estimate the overall probability of a medical outcome resulting from 2 independent events. DESIGN, SETTING, AND PARTICIPANTS This survey study consisted of 3 separate substudies, in which 215 physicians were asked via internet-based survey to estimate the probability of success of each of 2 components of a diagnostic or prognostic sequence as well as the overall probability of success of the 2-step sequence. Substudy 1 was performed from April 2 to 4, 2021, substudy 2 from November 2 toll, 2021, and substudy 3 from May 13 to 19, 2021. All physicians were board certified or board eligible in the primary specialty germane to the substudy (ie, obstetrics and gynecology for substudies land 3 and pulmonology for substudy 2), were recruited from a commercial survey service, and volunteered to participate in the study. EXPOSURES Case scenarios presented in an online survey. MAIN OUTCOMES AND MEASURES Respondents were asked to provide their demographic information in addition to 3 probability estimates. The first substudy included a scenario describing a brow presentation discovered during labor; the 2 conjuncts were the probabilities that the brow presentation would resolve and that the delivery would be vaginal. The second substudy involved a diagnostic evaluation of an incidentally discovered pulmonary nodule; the 2 conjuncts were the probabilities that the patient had a malignant condition and that a technically successful transthoracic needle biopsy would reveal a malignant condition. The third substudy included a modification of the first substudy in an attempt to debias the conjunction fallacy prevalent in the first substudy. Respondents' own probability estimates of the individual events were used to calculate the mathematically correct conjunctive probability. RESULTS Among 215 respondents, the mean (SD) age was 54.0 (9.5) years; 142 respondents (66.0\%) were male. Data on race and ethnicity were not collected. A total of 168 physicians (78.1\%) estimated the probability of the 2-step sequence to be greater than the probability of at least 1 of the 2 component events. Compared with the product of their 2 estimated components, respondents overestimated the combined probability by 12.8\% (95\% CI, 9.6\%-16.1\%; P < .001) in substudy 1, 19.8\% (95\% Cl, 16.6\%-23.0\%; P < .001) in substudy 2, and 18.0\% (95\% CI, 13.4\%-22.5\%; P < .001) in substudy 3, results that were mathematically incoherent (ie, formally illogical and mathematically incorrect). CONCLUSIONS AND RELEVANCE In this survey study of 215 physicians, respondents consistently overestimated the combined probability of 2 events compared with the probability calculated from their own estimates of the individual events. This biased estimation, consistent with the conjunction fallacy, may have substantial implications for diagnostic and prognostic decision-making.},
  language  = {en}
}
@article{SchenkeSchjeidePuescheletal.2020,
  author    = {Schenke, Maren and Schjeide, Brit-Maren and P{\"u}schel, Gerhard Paul and Seeger, Bettina},
  title     = {Analysis of motor neurons differentiated from human induced pluripotent stem cells for the use in cell-based Botulinum neurotoxin activity assays},
  series = {Toxins},
  volume    = {12},
  journal   = {Toxins},
  number    = {5},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6651},
  doi       = {10.3390/toxins12050276},
  pages     = {20},
  year      = {2020},
  abstract  = {Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs). For the potency assessment of BoNTs produced for treatment in traditional and aesthetic medicine, the mouse lethality assay is still used by the majority of manufacturers, which is ethically questionable in terms of the 3Rs principle. In this study, MNs were differentiated from human induced pluripotent stem cells based on three published protocols. The resulting cell populations were analyzed for their MN yield and their suitability for the potency assessment of BoNTs. MNs produce specific gangliosides and synaptic proteins, which are bound by BoNTs in order to be taken up by receptor-mediated endocytosis, which is followed by cleavage of specific soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) proteins required for neurotransmitter release. The presence of receptors and substrates for all BoNT serotypes was demonstrated in MNs generated in vitro. In particular, the MN differentiation protocol based on Du et al. yielded high numbers of MNs in a short amount of time with high expression of BoNT receptors and targets. The resulting cells are more sensitive to BoNT/A1 than the commonly used neuroblastoma cell line SiMa. MNs are, therefore, an ideal tool for being combined with already established detection methods.},
  language  = {en}
}
@misc{Degen2023,
  author    = {Degen, Andreas},
  title     = {Analyse visueller Wahrnehmungsqualit{\"a}ten von Lyrik},
  series = {Textpraxis : digitales Journal f{\"u}r Philologie / Sonderausgabe},
  volume    = {7},
  journal   = {Textpraxis : digitales Journal f{\"u}r Philologie / Sonderausgabe},
  number    = {2},
  publisher = {Westf{\"a}lische Wilhelms-Universit{\"a}t},
  address   = {M{\"u}nster},
  issn      = {2191-8236},
  doi       = {10.17879/19958489288},
  pages     = {4},
  year      = {2023},
  abstract  = {Das Projekt besch{\"a}ftigt sich mit der visuellen Wirkungsdimension von Lyrik und der M{\"o}glichkeit ihrer analytischen Beschreibung. Daf{\"u}r werden die Anordnung von Versen und W{\"o}rtern, Auszeichnungen und andere typographische Strukturen von nicht experimentellen Gedichten seit Ende des 18. Jahrhunderts im Rahmen von Modellanalysen untersucht.},
  language  = {de}
}
@article{VorogushynApelKemteretal.2022,
  author    = {Vorogushyn, Sergiy and Apel, Heiko and Kemter, Matthias and Thieken, Annegret},
  title     = {Analyse der Hochwassergef{\"a}hrdung im Ahrtal unter Ber{\"u}cksichtigung historischer Hochwasser},
  series = {Hydrologie und Wasserbewirtschaftung},
  volume    = {66},
  journal   = {Hydrologie und Wasserbewirtschaftung},
  number    = {5},
  publisher = {Bundesanst. f{\"u}r Gew{\"a}sserkunde},
  address   = {Koblenz},
  issn      = {1439-1783},
  doi       = {10.5675/HyWa_2022.5_2},
  pages     = {244 -- 254},
  year      = {2022},
  abstract  = {The flood disaster in July 2021 in western Germany calls for a critical discussion on flood hazard assessment, revision of flood hazard maps and communication of extreme flood scenarios. In the presented work, extreme value analysis was carried out for annual maximum peak flow series at the Altenahr gauge on the river Ahr. We compared flood statistics with and without considering historical flood events. An estimate for the return period of the recent flood based on the Generalized Extreme Value (GEV) distribution considering historical floods ranges between about 2600 and above 58700 years (90\% confidence interval) with a median of approximately 8600 years, whereas an estimate based on the 74-year long systematically recorded flow series would theoretically exceed 100 million years. Consideration of historical floods dramatically changes the flood quantiles that are used for the generation of official flood hazard maps. The fitting of the GEV to the time series with historical floods reveals, however, that the model potentially inadequately reflects the flood population. In this case, we might face a mixed sample, in which extreme floods result from very different processes compared to smaller floods. Hence, the probabilities of extreme floods could be much larger than those resulting from a single GEV model. The application of a process-based mixed flood distribution should be explored in future work. <br /> The comparison of the official HQextrem flood maps for the AhrValley with the inundation areas from July 2021 shows a striking discrepancy in the affected areas and calls for revision of design values used to define extreme flood scenarios. The hydrodynamic simulations of a 1000-year return period flood considering historical events and of the 1804 flood scenario compare much better to the flooded areas from July 2021, though both scenarios still underestimated the flood extent. <br /> Particular effects such as clogging of bridges and geomorphological changes of the river channel led to considerably larger flooded areas in July 2021 compared to the simulation results. Based on this analysis, we call for a consistent definition of HQextrem for flood hazard mapping in Germany, and suggest using high flood quantiles in the range of a 1,000-year flood. Flood maps should additionally include model-based reconstructions of the largest, reliably documented historical floods and/or synthetic worst-case scenarios. This would be an important step towards protecting potentially affected population and disaster management from surprises due to very rare and extreme flood events in future.},
  language  = {de}
}
@article{ThomasCarvalhoHaileetal.2017,
  author    = {Thomas, Jessica E. and Carvalho, Gary R. and Haile, James and Martin, Michael D. and Castruita, Jose A. Samaniego and Niemann, Jonas and Sinding, Mikkel-Holger S. and Sandoval-Velasco, Marcela and Rawlence, Nicolas J. and Fuller, Errol and Fjeldsa, Jon and Hofreiter, Michael and Stewart, John R. and Gilbert, M. Thomas P. and Knapp, Michael},
  title     = {An ‛Aukward' tale},
  series = {Genes},
  volume    = {8},
  journal   = {Genes},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4425},
  doi       = {10.3390/genes8060164},
  pages     = {164},
  year      = {2017},
  abstract  = {One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which—if any—of Fuller's candidate skins likely belong to either of the two birds. Using mitochondrial genomes from the five candidate birds (housed in museums in Bremen, Brussels, Kiel, Los Angeles, and Oldenburg) and the organs of the last two known individuals, we partially solve the mystery that has been on Great Auk scholars' minds for generations and make new suggestions as to the whereabouts of the still-missing skin from these two birds.},
  language  = {en}
}
@article{VencesKoehlerCrottinietal.2022,
  author    = {Vences, Miguel and K{\"o}hler, J{\"o}rn and Crottini, Angelica and Hofreiter, Michael and Hutter, Carl R. and du Preez, Louis and Preick, Michaela and Rakotoarison, Andolalao and Rancilhac, Lo{\"i}s and Raselimanana, Achille P. and Rosa, Gon{\c{c}}alo M. and Scherz, Mark D. and Glaw, Frank},
  title     = {An integrative taxonomic revision and redefinition of Gephyromantis (Laurentomantis) malagasius based on archival DNA analysis reveals four new mantellid frog species from Madagascar},
  series = {Vertebrate zoology},
  volume    = {72},
  journal   = {Vertebrate zoology},
  publisher = {Senckenberg Gesellschaft f{\"u}r Naturforschung},
  address   = {Frankfurt am Main},
  issn      = {1864-5755},
  doi       = {10.3897/vz.72.e78830},
  pages     = {271 -- 309},
  year      = {2022},
  abstract  = {The subgenus Laurentomantis in the genus Gephyromantis contains some of the least known amphibian species of Madagascar. The six currently valid nominal species are rainforest frogs known from few individuals, hampering a full understanding of the species diversity of the clade. We assembled data on specimens collected during field surveys over the past 30 years and integrated analysis of mitochondrial and nuclear-encoded genes of 88 individuals, a comprehensive bioacoustic analysis, and morphological comparisons to delimit a minimum of nine species-level lineages in the subgenus. To clarify the identity of the species Gephyromantis malagasius, we applied a target-enrichment approach to a sample of the 110 year old holotype of Microphryne malagasia Methuen and Hewitt, 1913 to assign this specimen to a lineage based on a mitochondrial DNA barcode. The holotype clustered unambiguously with specimens previously named G. ventrimaculatus. Consequently we propose to consider Trachymantis malagasia ventrimaculatus Angel, 1935 as a junior synonym of Gephyromantis malagasius. Due to this redefinition of G. malagasius, no scientific name is available for any of the four deep lineages of frogs previously subsumed under this name, all characterized by red color ventrally on the hindlimbs. These are here formally named as Gephyromantis fiharimpe sp. nov., G. matsilo sp. nov., G. oelkrugi sp. nov., and G. portonae sp. nov. The new species are distinguishable from each other by genetic divergences of >4\% uncorrected pairwise distance in a fragment of the 16S rRNA marker and a combination of morphological and bioacoustic characters. Gephyromantis fiharimpe and G. matsilo occur, respectively, at mid-elevations and lower elevations along a wide stretch of Madagascar's eastern rainforest band, while G. oelkrugi and G. portonae appear to be more range-restricted in parts of Madagascar's North East and Northern Central East regions. Open taxonomic questions surround G. horridus, to which we here assign specimens from Montagne d'Ambre and the type locality Nosy Be; and G. ranjomavo, which contains genetically divergent populations from Marojejy, Tsaratanana, and Ampotsidy.},
  language  = {en}
}
@article{HoanRichterBorsigetal.2022,
  author    = {Hoan, Tran Viet and Richter, Karl-Gerd and Borsig, Nicolas and Bauer, Jonas and Ha, Nguyen Thi and Norra, Stefan},
  title     = {An improved groundwater model framework for aquifer structures of the quaternary-formed sediment body in the southernmost parts of the Mekong Delta, Vietnam},
  series = {Hydrology : open access journal},
  volume    = {9},
  journal   = {Hydrology : open access journal},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2306-5338},
  doi       = {10.3390/hydrology9040061},
  pages     = {20},
  year      = {2022},
  abstract  = {The Ca Mau peninsula (CMP) is a key economic region in southern Vietnam. In recent decades, the high demand for water has increased the exploitation of groundwater, thus lowering the groundwater level and leading to risks of degradation, depletion, and land subsidence, as well as salinity intrusion in the groundwater of the whole Mekong Delta region. By using a finite element groundwater model with boundary expansion to the sea, we updated the latest data on hydrogeological profiles, groundwater levels, and exploitation. The basic model setup covers seven aquifers and seven aquitards. It is determined that the inflow along the coastline to the mainland is 39\% of the total inflow. The exploitation of the study area in 2019 was 567,364 m(3)/day. The most exploited aquifers are the upper-middle Pleistocene (qp(2-3)) and the middle Pliocene (n(2)(2)), accounting for 63.7\% and 24.6\%, respectively; the least exploited aquifers are the upper Pleistocene and the upper Miocene, accounting for 0.35\% and 0.02\%, respectively. In the deeper aquifers, qp(2-3) and n(2)(2), the change in storage is negative due to the high exploitation rate, leading to a decline in the reserves of these aquifers. These groundwater model results are the calculations of groundwater reserves from the coast to the mainland in the entire system of aquifers in the CMP. This makes groundwater decision managers, stakeholders, and others more efficient in sustainable water resources planning in the CMP and Mekong Delta (MKD).},
  language  = {en}
}
@article{NakoudiStachlewskaRitter2021,
  author    = {Nakoudi, Konstantina and Stachlewska, Iwona S. and Ritter, Christoph},
  title     = {An extended lidar-based cirrus cloud retrieval scheme},
  series = {Optics express : the international electronic journal of optics / Optica},
  volume    = {29},
  journal   = {Optics express : the international electronic journal of optics / Optica},
  number    = {6},
  publisher = {Optical Society of America},
  address   = {Washington},
  issn      = {1094-4087},
  doi       = {10.1364/OE.414770},
  pages     = {8553 -- 8580},
  year      = {2021},
  abstract  = {Accurate and precise characterization of cirrus cloud geometrical and optical properties is essential for better constraining their radiative footprint. A lidar-based retrieval scheme is proposed here, with its performance assessed on fine spatio-temporal observations over the Arctic site of Ny-Alesund, Svalbard. Two contributions related to cirrus geometrical (dynamic Wavelet Covariance Transform (WCT)) and optical properties (constrained Klett) are reported. The dynamic WCT rendered cirrus detection more robust, especially for thin cirrus layers that frequently remained undetected by the classical WCT method. Regarding optical characterization, we developed an iterative scheme for determining the cirrus lidar ratio (LRci) that is a crucial parameter for aerosol - cloud discrimination. Building upon the Klett-Fernald method, the LRci was constrained by an additional reference value. In established methods, such as the double-ended Klett, an aerosol-free reference value is applied. In the proposed constrained Klett, however, the reference value was approximated from cloud-free or low cloud optical depth (COD up to 0.2) profiles and proved to agree with independent Raman estimates. For optically thin cirrus, the constrained Klett inherent uncertainties reached 50\% (60-74\%) in terms of COD (LRci). However, for opaque cirrus COD (LRci) uncertainties were lower than 10\% (15\%). The detection method discrepancies (dynamic versus static WCT) had a higher impact on the optical properties of low COD layers (up to 90\%) compared to optically thicker ones (less than 10\%). The constrained Klett presented high agreement with two established retrievals. For an exemplary cirrus cloud, the constrained Klett estimated the COD355 (LRci355) at 0.28 +/- 0.17 (29 +/- 4 sr), the double-ended Klett at 0.27 +/- 0.15 (32 +/- 4 sr) and the Raman retrievals at 0.22 +/- 0.12 (26 +/- 11 sr). Our approach to determine the necessary reference value can also be applied in established methods and increase their accuracy. In contrast, the classical aerosol-free assumption led to 44 sr LRci overestimation in optically thin layers and 2-8 sr in thicker ones. The multiple scattering effect was corrected using Eloranta (1998) and accounted for 50-60\% extinction underestimation near the cloud base and 20-30\% within the cirrus layers.},
  language  = {en}
}
@article{SallehRamosMadrigalPenalozaetal.2017,
  author    = {Salleh, Faezah Mohd and Ramos-Madrigal, Jazmin and Penaloza, Fernando and Liu, Shanlin and Sinding, Mikkel-Holger S. and Patel, Riddhi P. and Martins, Renata and Lenz, Dorina and Fickel, J{\"o}rns and Roos, Christian and Shamsir, Mohd Shahir and Azman, Mohammad Shahfiz and Lim, Burton K. and Rossiter, Stephen J. and Wilting, Andreas and Gilbert, M. Thomas P.},
  title     = {An expanded mammal mitogenome dataset from Southeast Asia},
  series = {Gigascience},
  volume    = {6},
  journal   = {Gigascience},
  number    = {8},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {2047-217X},
  pages     = {1 -- 19},
  year      = {2017},
  abstract  = {Background: Findings: Approximately 55 gigabases of raw sequence were generated. From this data we assembled 72 complete mitogenome sequences, with an average depth of coverage of 102.9x and 55.2x for modern samples and historical samples, respectively. This dataset represents 52 species, of which 30 species had no previous mitogenome data available. The mitogenomes were geotagged to their sampling location, where known, to display a detailed geographical distribution of the species. Conclusion:},
  language  = {en}
}
@article{DreherBaldermannSchreineretal.2019,
  author    = {Dreher, Dorothee and Baldermann, Susanne and Schreiner, Monika and Hause, Bettina},
  title     = {An arbuscular mycorrhizal fungus and a root pathogen induce different volatiles emitted by Medicago truncatula roots},
  series = {Journal of Advanced Research},
  volume    = {19},
  journal   = {Journal of Advanced Research},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2090-1232},
  doi       = {10.1016/j.jare.2019.03.002},
  pages     = {85 -- 90},
  year      = {2019},
  abstract  = {Plants are in permanent contact with various microorganisms and are always impacted by them. To better understand the first steps of a plant's recognition of soil-borne microorganisms, the early release of volatile organic compounds (VOCs) emitted from roots of Medicago truncatula in response to the symbiont Rhizophagus irregularis or the pathogenic oomycete Aphanomyces euteiches was analysed. More than 90 compounds were released from roots as detected by an untargeted gas chromatography-mass spectrometry approach. Principal component analyses clearly distinguished untreated roots from roots treated with either R. irregularis or A. euteiches. Several VOCs were found to be emitted specifically in response to each of the microorganisms. Limonene was specifically emitted from wild-type roots after contact with R. irregularis spores but not from roots of the mycorrhiza-deficient mutant does not make infections3. The application of limonene to mycorrhizal roots, however, did not affect the mycorrhization rate. Inoculation of roots with A. euteiches zoospores resulted in the specific emission of several sesquiterpenes, such as nerolidol, viridiflorol and nerolidol-epoxyacetate but application of nerolidol to zoospores of A. euteiches did not affect their vitality. Therefore, plants discriminate between different microorganisms at early stages of their interaction and respond differently to the level of root-emitted volatiles.},
  language  = {en}
}
@article{AloniPerovicWeitmanetal.2019,
  author    = {Aloni, Sapir Shekef and Perovic, Milena and Weitman, Michal and Cohen, Reut and Oschatz, Martin and Mastai, Yitzhak},
  title     = {Amino acid-based ionic liquids as precursors for the synthesis of chiral nanoporous carbons},
  series = {Nanoscale Advances},
  volume    = {1},
  journal   = {Nanoscale Advances},
  number    = {12},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2516-0230},
  doi       = {10.1039/c9na00520j},
  pages     = {4981 -- 4988},
  year      = {2019},
  abstract  = {The synthesis of chiral nanoporous carbons based on chiral ionic liquids (CILs) of amino acids as precursors is described. Such unique precursors for the carbonization of CILs yield chiral carbonaceous materials with high surface area (approximate to 620 m(2) g(-1)). The enantioselectivities of the porous carbons are examined by advanced techniques such as selective adsorption of enantiomers using cyclic voltammetry, isothermal titration calorimetry, and mass spectrometry. These techniques demonstrate the chiral nature and high enantioselectivity of the chiral carbon materials. Overall, we believe that the novel approach presented here can contribute significantly to the development of new chiral carbon materials that will find important applications in chiral chemistry, such as in chiral catalysis and separation and in chiral sensors. From a scientific point of view, the approach and results reported here can significantly deepen our understanding of chirality at the nanoscale and of the structure and nature of chiral nonporous materials and surfaces.},
  language  = {en}
}
@article{NaolouLendleinNeffe2019,
  author    = {Naolou, Toufik and Lendlein, Andreas and Neffe, Axel T.},
  title     = {Amides as non-polymerizable catalytic adjuncts enable the ring-opening polymerization of lactide with ferrous acetate under mild conditions},
  series = {Frontiers in Chemistry},
  volume    = {7},
  journal   = {Frontiers in Chemistry},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {2296-2646},
  doi       = {10.3389/fchem.2019.00346},
  pages     = {12},
  year      = {2019},
  abstract  = {Sn-based catalysts are effective in the ring-opening polymerization (ROP) but are toxic. Fe(OAc)(2) used as an alternative catalyst is suitable for the ROP of lactide only at higher temperatures (>170 degrees C), associated with racemization. In the ROP of ester and amide group containing morpholinediones with Fe(OAc)(2) to polydepsipeptides at 135 degrees C, ester bonds were selectively opened. Here, it was hypothesized that ROP of lactones is possible with Fe(OAc)(2) when amides are present in the reactions mixture as Fe-ligands could increase the solubility and activity of the metal catalytic center. The ROP of lactide in the melt with Fe(OAc)(2) is possible at temperatures as low as 105 degrees C, in the presence of N-ethylacetamide or N-rnethylbenzamide as non-polymerizable catalytic adjuncts (NPCA), with high conversion (up to 99 mol\%) and yield (up to 88 mol\%). Polydispersities of polylactide decreased with decreasing reaction temperature to <= 1.1. NMR as well as polarimetric studies showed that no racemization occurred at reaction temperatures <= 145 degrees C. A kinetic study demonstrated a living chain-growth mechanism. MALDI analysis revealed that no side reactions (e.g., cyclization) occurred, though transesterification took place.},
  language  = {en}
}
@article{LangeBuerkner2021,
  author    = {Lange, Bastian and B{\"u}rkner, Hans-Joachim},
  title     = {Ambiguous avant-gardes and their geographies},
  series = {Die Erde : journal of the Geographical Society of Berlin ; Zeitschrift der Gesellschaft f{\"u}r Erdkunde zu Berlin},
  volume    = {152},
  journal   = {Die Erde : journal of the Geographical Society of Berlin ; Zeitschrift der Gesellschaft f{\"u}r Erdkunde zu Berlin},
  number    = {4},
  publisher = {Gesellschaft f{\"u}r Erdkunde},
  address   = {Berlin},
  issn      = {0013-9998},
  doi       = {10.12854/erde-2021-566},
  pages     = {273 -- 287},
  year      = {2021},
  abstract  = {In the following article, the focus is on the transformative potentials created by so-called persistence avant-gardes and prevention innovators. The text extends Bluhdorn's guiding concept of narratives of hope (Bluhdorn 2017; Bluhdorn and Butzlaff 2019) by considering those groups that are marginalized within debates on socio-ecological transformation. With a closer look at the narratives of prevention and blockade that these actors engage, the ambiguous nature of postgrowth avant-gardes is carved out. Their discursive, argumentative, and effective inhibition of transitory policies is interpreted as a pro-active potential, rather than a mere obstacle to socio-ecological transformation. Adding a geographical perspective, the paper pleads for a more precise theoretical penetration of the ambivalent figure of avantgardes when analyzing processes of local and regional postgrowth.},
  language  = {en}
}
@article{SchroeterNeugartSchreineretal.2019,
  author    = {Schr{\"o}ter, David and Neugart, Susanne and Schreiner, Monika and Grune, Tilman and Rohn, Sascha and Ott, Christiane},
  title     = {Amaranth's 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages},
  series = {Nutrients},
  volume    = {11},
  journal   = {Nutrients},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6643},
  doi       = {10.3390/nu11030571},
  pages     = {14},
  year      = {2019},
  abstract  = {For centuries, Amaranthus sp. were used as food, ornamentals, and medication. Molecular mechanisms, explaining the health beneficial properties of amaranth, are not yet understood, but have been attributed to secondary metabolites, such as phenolic compounds. One of the most abundant phenolic compounds in amaranth leaves is 2-caffeoylisocitric acid (C-IA) and regarding food occurrence, C-IA is exclusively found in various amaranth species. In the present study, the anti-inflammatory activity of C-IA, chlorogenic acid, and caffeic acid in LPS-challenged macrophages (RAW 264.7) has been investigated and cellular contents of the caffeic acid derivatives (CADs) were quantified in the cells and media. The CADs were quantified in the cell lysates in nanomolar concentrations, indicating a cellular uptake. Treatment of LPS-challenged RAW 264.7 cells with 10 µM of CADs counteracted the LPS effects and led to significantly lower mRNA and protein levels of inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin 6, by directly decreasing the translocation of the nuclear factor κB/Rel-like containing protein 65 into the nucleus. This work provides new insights into the molecular mechanisms that attribute to amaranth's anti-inflammatory properties and highlights C-IA's potential as a health-beneficial compound for future research.},
  language  = {en}
}
@article{StreflerKrieglerBaueretal.2021,
  author    = {Strefler, Jessica and Kriegler, Elmar and Bauer, Nico and Luderer, Gunnar and Pietzcker, Robert C. and Giannousakis, Anastasis and Edenhofer, Ottmar},
  title     = {Alternative carbon price trajectories can avoid excessive carbon removal},
  series = {Nature communications},
  volume    = {12},
  journal   = {Nature communications},
  number    = {1},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-021-22211-2},
  pages     = {8},
  year      = {2021},
  abstract  = {The large majority of climate change mitigation scenarios that hold warming below 2 °C show high deployment of carbon dioxide removal (CDR), resulting in a peak-and-decline behavior in global temperature. This is driven by the assumption of an exponentially increasing carbon price trajectory which is perceived to be economically optimal for meeting a carbon budget. However, this optimality relies on the assumption that a finite carbon budget associated with a temperature target is filled up steadily over time. The availability of net carbon removals invalidates this assumption and therefore a different carbon price trajectory should be chosen. We show how the optimal carbon price path for remaining well below 2 °C limits CDR demand and analyze requirements for constructing alternatives, which may be easier to implement in reality. We show that warming can be held at well below 2 °C at much lower long-term economic effort and lower CDR deployment and therefore lower risks if carbon prices are high enough in the beginning to ensure target compliance, but increase at a lower rate after carbon neutrality has been reached.},
  language  = {en}
}
@article{WarszawskiKrieglerLentonetal.2021,
  author    = {Warszawski, Lila and Kriegler, Elmar and Lenton, Timothy M. and Gaffney, Owen and Jacob, Daniela and Klingenfeld, Daniel and Koide, Ryu and Costa, Mar{\´i}a M{\´a}{\~n}ez and Messner, Dirk and Nakicenovic, Nebojsa and Schellnhuber, Hans Joachim and Schlosser, Peter and Takeuchi, Kazuhiko and van der Leeuw, Sander and Whiteman, Gail and Rockstr{\"o}m, Johan},
  title     = {All options, not silver bullets, needed to limit global warming to 1.5 °C},
  series = {Environmental research letters},
  volume    = {16},
  journal   = {Environmental research letters},
  number    = {6},
  publisher = {IOP Publishing},
  address   = {Bristol},
  issn      = {1748-9326},
  doi       = {10.1088/1748-9326/abfeec},
  pages     = {15},
  year      = {2021},
  abstract  = {Climate science provides strong evidence of the necessity of limiting global warming to 1.5 °C, in line with the Paris Climate Agreement. The IPCC 1.5 °C special report (SR1.5) presents 414 emissions scenarios modelled for the report, of which around 50 are classified as '1.5 °C scenarios', with no or low temperature overshoot. These emission scenarios differ in their reliance on individual mitigation levers, including reduction of global energy demand, decarbonisation of energy production, development of land-management systems, and the pace and scale of deploying carbon dioxide removal (CDR) technologies. The reliance of 1.5 °C scenarios on these levers needs to be critically assessed in light of the potentials of the relevant technologies and roll-out plans. We use a set of five parameters to bundle and characterise the mitigation levers employed in the SR1.5 1.5 °C scenarios. For each of these levers, we draw on the literature to define 'medium' and 'high' upper bounds that delineate between their 'reasonable', 'challenging' and 'speculative' use by mid century. We do not find any 1.5 °C scenarios that stay within all medium upper bounds on the five mitigation levers. Scenarios most frequently 'over use' CDR with geological storage as a mitigation lever, whilst reductions of energy demand and carbon intensity of energy production are 'over used' less frequently. If we allow mitigation levers to be employed up to our high upper bounds, we are left with 22 of the SR1.5 1.5 °C scenarios with no or low overshoot. The scenarios that fulfil these criteria are characterised by greater coverage of the available mitigation levers than those scenarios that exceed at least one of the high upper bounds. When excluding the two scenarios that exceed the SR1.5 carbon budget for limiting global warming to 1.5 °C, this subset of 1.5 °C scenarios shows a range of 15-22 Gt CO2 (16-22 Gt CO2 interquartile range) for emissions in 2030. For the year of reaching net zero CO2 emissions the range is 2039-2061 (2049-2057 interquartile range).},
  language  = {en}
}
@misc{Ette2019,
  author    = {Ette, Ottmar},
  title     = {Alexander von Humboldt y Am{\´e}rica Latina},
  series = {Iberoamericana},
  volume    = {19},
  journal   = {Iberoamericana},
  number    = {70},
  publisher = {Vervuert},
  address   = {Frankfurt am Main},
  issn      = {1577-3388},
  doi       = {10.18441/ibam.19.2019.70.7-8},
  pages     = {7 -- 8},
  year      = {2019},
  abstract  = {Bas{\´a}ndose en el conjunto de la obra humboldtiana, desde sus comienzos hasta el Cosmos, este dossier trata de destacar la orientaci{\´o}n cosmopolita del sabio prusiano as{\´i} como, sobre todo, el fundamento americano de sus enfoques. El continente americano, para Humboldt, representa la diversidad de lo pensable y la multirrelacionalidad de lo imaginable: la llave para entender su cosmovisi{\´o}n.},
  language  = {es}
}
@article{MenzeMuellerMuelleretal.2022,
  author    = {Menze, Inga and M{\"u}ller, Patrick and M{\"u}ller, Notger Germar and Schmicker, Marlen},
  title     = {Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Nature portfolio},
  address   = {Berlin},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-11283-9},
  pages     = {16},
  year      = {2022},
  abstract  = {Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health. Here we asked how restriction-related changes influence cognitive performance and how age, perceived loneliness, depressiveness and affectedness by restrictions contribute to these effects. 51 Germans completed three assessments of an online based study during the first lockdown in Germany (April 2020), a month later, and during the beginning of the second lockdown (November 2020). Participants completed nine online cognitive tasks of the MyBrainTraining and online questionnaires about their perceived strain and impact on lifestyle factors by the situation (affectedness), perceived loneliness, depressiveness as well as subjective cognitive performance. The results suggested a possible negative impact of depressiveness and affectedness on objective cognitive performance within the course of the lockdown. The younger the participants, the more pronounced these effects were. Loneliness and depressiveness moreover contributed to a worse evaluation of subjective cognition. In addition, especially younger individuals reported increased distress. As important educational and social input has partly been scarce during this pandemic and mental health problems have increased, future research should also assess cognitive long-term consequences.},
  language  = {en}
}
@article{ZuhrDolmanHoetal.2022,
  author    = {Zuhr, Alexandra M. and Dolman, Andrew M. and Ho, Sze Ling and Groeneveld, Jeroen and Loewemark, Ludvig and Grotheer, Hendrik and Su, Chih-Chieh and Laepple, Thomas},
  title     = {Age-heterogeneity in marine sediments revealed by three-dimensional high-resolution radiocarbon measurements},
  series = {Frontiers in Earth Science},
  volume    = {10},
  journal   = {Frontiers in Earth Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-6463},
  doi       = {10.3389/feart.2022.871902},
  pages     = {15},
  year      = {2022},
  abstract  = {Marine sedimentary archives are routinely used to reconstruct past environmental changes. In many cases, bioturbation and sedimentary mixing affect the proxy time-series and the age-depth relationship. While idealized models of bioturbation exist, they usually assume homogeneous mixing, thus that a single sample is representative for the sediment layer it is sampled from. However, it is largely unknown to which extent this assumption holds for sediments used for paleoclimate reconstructions. To shed light on 1) the age-depth relationship and its full uncertainty, 2) the magnitude of mixing processes affecting the downcore proxy variations, and 3) the representativity of the discrete sample for the sediment layer, we designed and performed a case study on South China Sea sediment material which was collected using a box corer and which covers the last glacial cycle. Using the radiocarbon content of foraminiferal tests as a tracer of time, we characterize the spatial age-heterogeneity of sediments in a three-dimensional setup. In total, 118 radiocarbon measurements were performed on defined small- and large-volume bulk samples ( similar to 200 specimens each) to investigate the horizontal heterogeneity of the sediment. Additionally, replicated measurements on small numbers of specimens (10 x 5 specimens) were performed to assess the heterogeneity within a sample volume. Visual assessment of X-ray images and a quantitative assessment of the mixing strength show typical mixing from bioturbation corresponding to around 10 cm mixing depth. Notably, our 3D radiocarbon distribution reveals that the horizontal heterogeneity (up to 1,250 years), contributing to the age uncertainty, is several times larger than the typically assumed radiocarbon based age-model error (single errors up to 250 years). Furthermore, the assumption of a perfectly bioturbated layer with no mixing underneath is not met. Our analysis further demonstrates that the age-heterogeneity might be a function of sample size; smaller samples might contain single features from the incomplete mixing and are thus less representative than larger samples. We provide suggestions for future studies, optimal sampling strategies for quantitative paleoclimate reconstructions and realistic uncertainty in age models, as well as discuss possible implications for the interpretation of paleoclimate records.},
  language  = {en}
}
@article{OdongoSchlotzBaldermannetal.2018,
  author    = {Odongo, Grace Akinyi and Schlotz, Nina and Baldermann, Susanne and Neugart, Susanne and Huyskens-Keil, Susanne and Ngwene, Benard and Trierweiler, Bernhard and Schreiner, Monika and Lamy, Evelyn},
  title     = {African Nightshade (Solanum scabrum Mill.)},
  series = {Nutrients},
  volume    = {10},
  journal   = {Nutrients},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6643},
  doi       = {10.3390/nu10101532},
  pages     = {20},
  year      = {2018},
  abstract  = {Plant cultivation and processing may impact nutrient and phytochemical content of vegetables. The present study aimed at determining the influence of cultivation and processing on the health promoting capacity of African nightshade (Solanum scabrum Mill.) leaves, an indigenous vegetable, rich in nutrients and phytochemicals. Anti-genotoxicity against the human liver carcinogen aflatoxin B1 (AFB(1)) as determined by the comet assay and radical oxygen species (ROS) scavenging capacity of ethanolic and aqueous extracts were investigated in human derived liver (HepG2) cells. ROS scavenging activity was assessed using electron paramagnetic spin resonance and quantification of ARE/Nrf2 mediated gene expression. The cultivation was done under different environmental conditions. The processing included fermentation and cooking; postharvest ultraviolet irradiation (UV-C) treatment was also investigated. Overall, S. scabrum extracts showed strong health promoting potential, the highest potential was observed with the fermented extract, which showed a 60\% reduction of AFB(1) induced DNA damage and a 38\% reduction in FeSO4 induced oxidative stress. The content of total polyphenols, carotenoids and chlorophylls was indeed affected by cultivation and processing. Based on the present in vitro findings consumption of S. scabrum leaves could be further encouraged, preferentially after cooking or fermentation of the plant.},
  language  = {en}
}
@article{RamachandranRupakhetiLawrence2020,
  author    = {Ramachandran, Srikanthan and Rupakheti, Maheswar and Lawrence, Mark},
  title     = {Aerosol-induced atmospheric heating rate decreases over South and East Asia as a result of changing content and composition},
  series = {Scientific reports},
  volume    = {10},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {[London]},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-020-76936-z},
  pages     = {17},
  year      = {2020},
  abstract  = {Aerosol emissions from human activities are extensive and changing rapidly over Asia. Model simulations and satellite observations indicate a dipole pattern in aerosol emissions and loading between South Asia and East Asia, two of the most heavily polluted regions of the world. We examine the previously unexplored diverging trends in the existing dipole pattern of aerosols between East and South Asia using the high quality, two-decade long ground-based time series of observations of aerosol properties from the Aerosol Robotic Network (AERONET), from satellites (Moderate Resolution Imaging Spectroradiometer (MODIS) and Ozone Monitoring Instrument (OMI)), and from model simulations (Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2). The data cover the period since 2001 for Kanpur (South Asia) and Beijing (East Asia), two locations taken as being broadly representative of the respective regions. Since 2010 a dipole in aerosol optical depth (AOD) is maintained, but the trend is reversed-the decrease in AOD over Beijing (East Asia) is rapid since 2010, being 17\% less in current decade compared to first decade of twenty-first century, while the AOD over South Asia increased by 12\% during the same period. Furthermore, we find that the aerosol composition is also changing over time. The single scattering albedo (SSA), a measure of aerosol's absorption capacity and related to aerosol composition, is slightly higher over Beijing than Kanpur, and has increased from 0.91 in 2002 to 0.93 in 2017 over Beijing and from 0.89 to 0.92 during the same period over Kanpur, confirming that aerosols in this region have on an average become more scattering in nature. These changes have led to a notable decrease in aerosol-induced atmospheric heating rate (HR) over both regions between the two decades, decreasing considerably more over East Asia (- 31\%) than over South Asia (- 9\%). The annual mean HR is lower now, it is still large (>= 0.6 K per day), which has significant climate implications. The seasonal trends in AOD, SSA and HR are more pronounced than their respective annual trends over both regions. The seasonal trends are caused mainly by the increase/decrease in anthropogenic aerosol emissions (sulfate, black carbon and organic carbon) while the natural aerosols (dust and sea salt) did not change significantly over South and East Asia during the last two decades. The MERRA-2 model is able to simulate the observed trends in AODs well but not the magnitude, while it also did not simulate the SSA values or trends well. These robust findings based on observations of key aerosol parameters and previously unrecognized diverging trends over South and East Asia need to be accounted for in current state-of-the-art climate models to ensure accurate quantification of the complex and evolving impact of aerosols on the regional climate over Asia.},
  language  = {en}
}
@article{WengLuedekeZempetal.2018,
  author    = {Weng, Wei and L{\"u}deke, Matthias K. B. and Zemp, Delphine Clara and Lakes, Tobia and Kropp, J{\"u}rgen},
  title     = {Aerial and surface rivers},
  series = {Hydrology and earth system sciences : HESS},
  volume    = {22},
  journal   = {Hydrology and earth system sciences : HESS},
  number    = {1},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1027-5606},
  doi       = {10.5194/hess-22-911-2018},
  pages     = {911 -- 927},
  year      = {2018},
  abstract  = {The abundant evapotranspiration provided by the Amazon forests is an important component of the hydrological cycle, both regionally and globally. Since the last century, deforestation and expanding agricultural activities have been changing the ecosystem and its provision of moisture to the atmosphere. However, it remains uncertain how the ongoing land use change will influence rainfall, runoff, and water availability as findings from previous studies differ. Using moisture tracking experiments based on observational data, we provide a spatially detailed analysis recognizing potential teleconnection between source and sink regions of atmospheric moisture. We apply land use scenarios in upwind moisture sources and quantify the corresponding rainfall and runoff changes in downwind moisture sinks. We find spatially varying responses of water regimes to land use changes, which may explain the diverse results from previous studies. Parts of the Peruvian Amazon and western Bolivia are identified as the sink areas most sensitive to land use change in the Amazon and we highlight the current water stress by Amazonian land use change on these areas in terms of the water availability. Furthermore, we also identify the influential source areas where land use change may considerably reduce a given target sink's water reception (from our example of the Ucayali River basin outlet, rainfall by 5-12 \% and runoff by 19-50 \% according to scenarios). Sensitive sinks and influential sources are therefore suggested as hotspots for achieving sustainable land-water management.},
  language  = {en}
}
@article{BriegerHerzschuhPestryakovaetal.2019,
  author    = {Brieger, Frederic and Herzschuh, Ulrike and Pestryakova, Luidmila Agafyevna and Bookhagen, Bodo and Zakharov, Evgenii S. and Kruse, Stefan},
  title     = {Advances in the Derivation of Northeast Siberian Forest Metrics Using High-Resolution UAV-Based Photogrammetric Point Clouds},
  series = {Remote sensing},
  volume    = {11},
  journal   = {Remote sensing},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-4292},
  doi       = {10.3390/rs11121447},
  pages     = {24},
  year      = {2019},
  abstract  = {Forest structure is a crucial component in the assessment of whether a forest is likely to act as a carbon sink under changing climate. Detailed 3D structural information about the tundra-taiga ecotone of Siberia is mostly missing and still underrepresented in current research due to the remoteness and restricted accessibility. Field based, high-resolution remote sensing can provide important knowledge for the understanding of vegetation properties and dynamics. In this study, we test the applicability of consumer-grade Unmanned Aerial Vehicles (UAVs) for rapid calculation of stand metrics in treeline forests. We reconstructed high-resolution photogrammetric point clouds and derived canopy height models for 10 study sites from NE Chukotka and SW Yakutia. Subsequently, we detected individual tree tops using a variable-window size local maximum filter and applied a marker-controlled watershed segmentation for the delineation of tree crowns. With this, we successfully detected 67.1\% of the validation individuals. Simple linear regressions of observed and detected metrics show a better correlation (R2) and lower relative root mean square percentage error (RMSE\%) for tree heights (mean R2 = 0.77, mean RMSE\% = 18.46\%) than for crown diameters (mean R2 = 0.46, mean RMSE\% = 24.9\%). The comparison between detected and observed tree height distributions revealed that our tree detection method was unable to representatively identify trees <2 m. Our results show that plot sizes for vegetation surveys in the tundra-taiga ecotone should be adapted to the forest structure and have a radius of >15-20 m to capture homogeneous and representative forest stands. Additionally, we identify sources of omission and commission errors and give recommendations for their mitigation. In summary, the efficiency of the used method depends on the complexity of the forest's stand structure.},
  language  = {en}
}
@misc{RandallJuengelRimannetal.2018,
  author    = {Randall, Matthew J. and J{\"u}ngel, Astrid and Rimann, Markus and Wuertz-Kozak, Karin},
  title     = {Advances in the biofabrication of 3D Skin in vitro},
  series = {Frontiers in Bioengineeringand Biotechnology},
  volume    = {6},
  journal   = {Frontiers in Bioengineeringand Biotechnology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {2296-4185},
  doi       = {10.3389/fbioe.2018.00154},
  pages     = {12},
  year      = {2018},
  abstract  = {The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.},
  language  = {en}
}
@misc{BaslerFernieNikoloski2018,
  author    = {Basler, Georg and Fernie, Alisdair R. and Nikoloski, Zoran},
  title     = {Advances in metabolic flux analysis toward genome-scale profiling of higher organisms},
  series = {Bioscience reports : communications and reviews in molecular and cellular biology},
  volume    = {38},
  journal   = {Bioscience reports : communications and reviews in molecular and cellular biology},
  publisher = {Portland Press (London)},
  address   = {London},
  issn      = {0144-8463},
  doi       = {10.1042/BSR20170224},
  pages     = {11},
  year      = {2018},
  abstract  = {Methodological and technological advances have recently paved the way for metabolic flux profiling in higher organisms, like plants. However, in comparison with omics technologies, flux profiling has yet to provide comprehensive differential flux maps at a genome-scale and in different cell types, tissues, and organs. Here we highlight the recent advances in technologies to gather metabolic labeling patterns and flux profiling approaches. We provide an opinion of how recent local flux profiling approaches can be used in conjunction with the constraint-based modeling framework to arrive at genome-scale flux maps. In addition, we point at approaches which use metabolomics data without introduction of label to predict either non-steady state fluxes in a time-series experiment or flux changes in different experimental scenarios. The combination of these developments allows an experimentally feasible approach for flux-based large-scale systems biology studies.},
  language  = {en}
}
@article{SchlappaBresselReichetal.2023,
  author    = {Schlappa, Stephanie and Bressel, Lena and Reich, Oliver and M{\"u}nzberg, Marvin},
  title     = {Advanced particle size analysis in high-solid-content polymer dispersions using photon density wave spectroscopy},
  series = {Polymers},
  volume    = {15},
  journal   = {Polymers},
  number    = {15},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4360},
  doi       = {10.3390/polym15153181},
  pages     = {17},
  year      = {2023},
  abstract  = {High-solid-content polystyrene and polyvinyl acetate dispersions of polymer particles with a 50 nm to 500 nm mean particle diameter and 12-55\% (w/w) solid content have been produced via emulsion polymerization and characterized regarding their optical and physical properties. Both systems have been analyzed with common particle-size-measuring techniques like dynamic light scattering (DLS) and static light scattering (SLS) and compared to inline particle size distribution (PSD) measurements via photon density wave (PDW) spectroscopy in undiluted samples. It is shown that particle size measurements of undiluted polystyrene dispersions are in good agreement between analysis methods. However, for polyvinyl acetate particles, size determination is challenging due to bound water in the produced polymer. For the first time, water-swelling factors were determined via an iterative approach of PDW spectroscopy error (X-2) minimization. It is shown that water-swollen particles can be analyzed in high-solid-content solutions and their physical properties can be assumed to determine the refractive index, density, and volume fraction in dispersion. It was found that assumed water swelling improved the reduced scattering coefficient fit by PDW spectroscopy by up to ten times and particle size determination was refined and enabled. Particle size analysis of the water-swollen particles agreed well with offline-based state-of-the-art techniques.},
  language  = {en}
}
@article{TaubertLerouxRabuetal.2019,
  author    = {Taubert, Andreas and Leroux, Fabrice and Rabu, Pierre and de Zea Bermudez, Veronica},
  title     = {Advanced hybrid nanomaterials},
  series = {Beilstein journal of nanotechnology},
  volume    = {10},
  journal   = {Beilstein journal of nanotechnology},
  publisher = {Beilstein-Institut zur F{\"o}rderung der Chemischen Wissenschaften},
  address   = {Frankfurt am Main},
  issn      = {2190-4286},
  doi       = {10.3762/bjnano.10.247},
  pages     = {2563 -- 2567},
  year      = {2019},
  language  = {en}
}
@article{BirukovCuadratPolemitietal.2021,
  author    = {Birukov, Anna and Cuadrat, Rafael R. C. and Polemiti, Elli and Eichelmann, Fabian and Schulze, Matthias Bernd},
  title     = {Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals},
  series = {Cardiovascular diabetology},
  volume    = {20},
  journal   = {Cardiovascular diabetology},
  number    = {1},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1475-2840},
  doi       = {10.1186/s12933-021-01296-5},
  pages     = {11},
  year      = {2021},
  abstract  = {Background Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships between advanced glycation end-products, measured as skin autofluorescence, and vascular stiffness in various glycemic strata. Methods We performed a cross-sectional analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort, comprising n = 3535 participants (median age 67 years, 60\% women). Advanced glycation end-products were measured as skin autofluorescence with AGE-Reader (TM), vascular stiffness was measured as pulse wave velocity, augmentation index and ankle-brachial index with Vascular Explorer (TM). A subset of 1348 participants underwent an oral glucose tolerance test. Participants were sub-phenotyped into normoglycemic, prediabetes and diabetes groups. Associations between skin autofluorescence and various indices of vascular stiffness were assessed by multivariable regression analyses and were adjusted for age, sex, measures of adiposity and lifestyle, blood pressure, prevalent conditions, medication use and blood biomarkers. Results Skin autofluorescence associated with pulse wave velocity, augmentation index and ankle-brachial index, adjusted beta coefficients (95\% CI) per unit skin autofluorescence increase: 0.38 (0.21; 0.55) for carotid-femoral pulse wave velocity, 0.25 (0.14; 0.37) for aortic pulse wave velocity, 1.00 (0.29; 1.70) for aortic augmentation index, 4.12 (2.24; 6.00) for brachial augmentation index and - 0.04 (- 0.05; - 0.02) for ankle-brachial index. The associations were strongest in men, younger individuals and were consistent across all glycemic strata: for carotid-femoral pulse wave velocity 0.36 (0.12; 0.60) in normoglycemic, 0.33 (- 0.01; 0.67) in prediabetes and 0.45 (0.09; 0.80) in diabetes groups; with similar estimates for aortic pulse wave velocity. Augmentation index was associated with skin autofluorescence only in normoglycemic and diabetes groups. Ankle-brachial index inversely associated with skin autofluorescence across all sex, age and glycemic strata. Conclusions Our findings indicate that advanced glycation end-products measured as skin autofluorescence might be involved in vascular stiffening independent of age and other cardiometabolic risk factors not only in individuals with diabetes but also in normoglycemic and prediabetic conditions. Skin autofluorescence might prove as a rapid and non-invasive method for assessment of macrovascular disease progression across all glycemic strata.},
  language  = {en}
}
@article{PoltrockChenKwoketal.2018,
  author    = {Poltrock, Silvana and Chen, Hui and Kwok, Celia and Cheung, Hintat and Nazzi, Thierry},
  title     = {Adult learning of novel words in a non-native language},
  series = {Frontiers in psychology},
  volume    = {9},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2018.01211},
  pages     = {15},
  year      = {2018},
  language  = {en}
}
@article{FoongPradhanFroeretal.2022,
  author    = {Foong, Adrian and Pradhan, Prajal and Fr{\"o}r, Oliver and Kropp, J{\"u}rgen P.},
  title     = {Adjusting agricultural emissions for trade matters for climate change mitigation},
  series = {Nature Communications},
  volume    = {13},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-022-30607-x},
  pages     = {10},
  year      = {2022},
  abstract  = {Reducing greenhouse gas emissions in food systems is becoming more challenging as food is increasingly consumed away from producer regions, highlighting the need to consider emissions embodied in trade in agricultural emissions accounting. To address this, our study explores recent trends in trade-adjusted agricultural emissions of food items at the global, regional, and national levels. We find that emissions are largely dependent on a country's consumption patterns and their agricultural emission intensities relative to their trading partners'. The absolute differences between the production-based and trade-adjusted emissions accounting approaches are especially apparent for major agricultural exporters and importers and where large shares of emission-intensive items such as ruminant meat, milk products and rice are involved. In relative terms, some low-income and emerging and developing economies with consumption of high emission intensity food products show large differences between approaches. Similar trends are also found under various specifications that account for trade and re-exports differently. These findings could serve as an important element towards constructing national emissions reduction targets that consider trading partners, leading to more effective emissions reductions overall.},
  language  = {en}
}
@article{RadchukReedTeplitskyetal.2019,
  author    = {Radchuk, Viktoriia and Reed, Thomas and Teplitsky, Celine and van de Pol, Martijn and Charmantier, Anne and Hassall, Christopher and Adamik, Peter and Adriaensen, Frank and Ahola, Markus P. and Arcese, Peter and Miguel Aviles, Jesus and Balbontin, Javier and Berg, Karl S. and Borras, Antoni and Burthe, Sarah and Clobert, Jean and Dehnhard, Nina and de Lope, Florentino and Dhondt, Andre A. and Dingemanse, Niels J. and Doi, Hideyuki and Eeva, Tapio and Fickel, J{\"o}rns and Filella, Iolanda and Fossoy, Frode and Goodenough, Anne E. and Hall, Stephen J. G. and Hansson, Bengt and Harris, Michael and Hasselquist, Dennis and Hickler, Thomas and Jasmin Radha, Jasmin and Kharouba, Heather and Gabriel Martinez, Juan and Mihoub, Jean-Baptiste and Mills, James A. and Molina-Morales, Mercedes and Moksnes, Arne and Ozgul, Arpat and Parejo, Deseada and Pilard, Philippe and Poisbleau, Maud and Rousset, Francois and R{\"o}del, Mark-Oliver and Scott, David and Carlos Senar, Juan and Stefanescu, Constanti and Stokke, Bard G. and Kusano, Tamotsu and Tarka, Maja and Tarwater, Corey E. and Thonicke, Kirsten and Thorley, Jack and Wilting, Andreas and Tryjanowski, Piotr and Merila, Juha and Sheldon, Ben C. and Moller, Anders Pape and Matthysen, Erik and Janzen, Fredric and Dobson, F. Stephen and Visser, Marcel E. and Beissinger, Steven R. and Courtiol, Alexandre and Kramer-Schadt, Stephanie},
  title     = {Adaptive responses of animals to climate change are most likely insufficient},
  series = {Nature Communications},
  volume    = {10},
  journal   = {Nature Communications},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-019-10924-4},
  pages     = {14},
  year      = {2019},
  abstract  = {Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species.},
  language  = {en}
}
@article{SchaeferDechBittmann2021,
  author    = {Schaefer, Laura and Dech, Silas and Bittmann, Frank},
  title     = {Adaptive force and emotionally related imaginations},
  series = {Heliyon},
  volume    = {7},
  journal   = {Heliyon},
  number    = {8},
  publisher = {Elsevier},
  address   = {London},
  issn      = {2405-8440},
  doi       = {10.1016/j.heliyon.2021.e07827},
  pages     = {13},
  year      = {2021},
  abstract  = {The link between emotions and motor control has been discussed for years. The measurement of the Adaptive Force (AF) provides the possibility to get insights into the adaptive control of the neuromuscular system in reaction to external forces. It was hypothesized that the holding isometric AF is especially vulnerable to disturbing inputs. Here, the behavior of the AF under the influence of positive (tasty) vs. negative (disgusting) food imaginations was investigated. The AF was examined in n = 12 cases using an objectified manual muscle test of the hip flexors, elbow flexors or pectoralis major muscle, performed by one of two experienced testers while the participants imagined their most tasty or most disgusting food. The reaction force and the limb position were measured by a handheld device. While the slope of force rises and the maximal AF did not differ significantly between tasty and disgusting imaginations (p > 0.05), the maximal isometric AF was significantly lower and the AF at the onset of oscillations was significantly higher under disgusting vs. tasty imaginations (both p = 0.001). A proper length tension control of muscles seems to be a crucial functional parameter of the neuromuscular system which can be impaired instantaneously by emotionally related negative imaginations. This might be a potential approach to evaluate somatic reactions to emotions.},
  language  = {en}
}
@article{PrieskeChaabeneMoranetal.2022,
  author    = {Prieske, Olaf and Chaabene, Helmi and Moran, Jason and Saeterbakken, Atle Hole},
  title     = {Adaptations to Advanced Resistance Training Strategies in Youth and Adult Athletes},
  series = {Frontiers in physiology / Frontiers Research Foundation},
  volume    = {13},
  journal   = {Frontiers in physiology / Frontiers Research Foundation},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2022.888118},
  pages     = {3},
  year      = {2022},
  language  = {en}
}
@article{KreibichDiBaldassarreVorogushynetal.2017,
  author    = {Kreibich, Heidi and Di Baldassarre, Giuliano and Vorogushyn, Sergiy and Aerts, Jeroen C. J. H. and Apel, Heiko and Aronica, Giuseppe T. and Arnbjerg-Nielsen, Karsten and Bouwer, Laurens M. and Bubeck, Philip and Caloiero, Tommaso and Chinh, Do T. and Cortes, Maria and Gain, Animesh K. and Giampa, Vincenzo and Kuhlicke, Christian and Kundzewicz, Zbigniew W. and Llasat, Maria Carmen and Mard, Johanna and Matczak, Piotr and Mazzoleni, Maurizio and Molinari, Daniela and Dung, Nguyen V. and Petrucci, Olga and Schr{\"o}ter, Kai and Slager, Kymo and Thieken, Annegret and Ward, Philip J. and Merz, Bruno},
  title     = {Adaptation to flood risk},
  series = {Earth's Future},
  volume    = {5},
  journal   = {Earth's Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000606},
  pages     = {953 -- 965},
  year      = {2017},
  abstract  = {As flood impacts are increasing in large parts of the world, understanding the primary drivers of changes in risk is essential for effective adaptation. To gain more knowledge on the basis of empirical case studies, we analyze eight paired floods, that is, consecutive flood events that occurred in the same region, with the second flood causing significantly lower damage. These success stories of risk reduction were selected across different socioeconomic and hydro-climatic contexts. The potential of societies to adapt is uncovered by describing triggered societal changes, as well as formal measures and spontaneous processes that reduced flood risk. This novel approach has the potential to build the basis for an international data collection and analysis effort to better understand and attribute changes in risk due to hydrological extremes in the framework of the IAHSs Panta Rhei initiative. Across all case studies, we find that lower damage caused by the second event was mainly due to significant reductions in vulnerability, for example, via raised risk awareness, preparedness, and improvements of organizational emergency management. Thus, vulnerability reduction plays an essential role for successful adaptation. Our work shows that there is a high potential to adapt, but there remains the challenge to stimulate measures that reduce vulnerability and risk in periods in which extreme events do not occur.},
  language  = {en}
}
@article{WutzlerHudsonThieken2022,
  author    = {Wutzler, Bianca and Hudson, Paul and Thieken, Annegret},
  title     = {Adaptation strategies of flood-damaged businesses in Germany},
  series = {Frontiers in water},
  volume    = {4},
  journal   = {Frontiers in water},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2624-9375},
  doi       = {10.3389/frwa.2022.932061},
  pages     = {13},
  year      = {2022},
  abstract  = {Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication.},
  language  = {en}
}
@article{WillnerLevermannZhaoetal.2018,
  author    = {Willner, Sven N. and Levermann, Anders and Zhao, Fang and Frieler, Katja},
  title     = {Adaptation required to preserve future high-end river flood risk at present levels},
  series = {Science Advances},
  volume    = {4},
  journal   = {Science Advances},
  number    = {1},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {2375-2548},
  doi       = {10.1126/sciadv.aao1914},
  pages     = {8},
  year      = {2018},
  abstract  = {Earth's surface temperature will continue to rise for another 20 to 30 years even with the strongest carbon emission reduction currently considered. The associated changes in rainfall patterns can result in an increased flood risk worldwide. We compute the required increase in flood protection to keep high-end fluvial flood risk at present levels. The analysis is carried out worldwide for subnational administrative units. Most of the United States, Central Europe, and Northeast and West Africa, as well as large parts of India and Indonesia, require the strongest adaptation effort. More than half of the United States needs to at least double their protection within the next two decades. Thus, the need for adaptation to increased river flood is a global problem affecting industrialized regions as much as developing countries.},
  language  = {en}
}
@article{DellepianeVaidJaladankietal.2021,
  author    = {Dellepiane, Sergio and Vaid, Akhil and Jaladanki, Suraj K. and Coca, Steven and Fayad, Zahi A. and Charney, Alexander W. and B{\"o}ttinger, Erwin and He, John Cijiang and Glicksberg, Benjamin S. and Chan, Lili and Nadkarni, Girish},
  title     = {Acute kidney injury in patients hospitalized with COVID-19 in New York City},
  series = {Kidney medicine},
  volume    = {3},
  journal   = {Kidney medicine},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2590-0595},
  doi       = {10.1016/j.xkme.2021.06.008},
  pages     = {877 -- 879},
  year      = {2021},
  language  = {en}
}
@article{ZinkeGebelGranacheretal.2019,
  author    = {Zinke, Fridolin and Gebel, Arnd and Granacher, Urs and Prieske, Olaf},
  title     = {Acute Effects of Short-Term Local Tendon Vibration on Plantar Flexor Torque, Muscle Contractile Properties, Neuromuscular and Brain Activity in Young Athletes},
  series = {Journal of sports science \& medicine},
  volume    = {18},
  journal   = {Journal of sports science \& medicine},
  number    = {2},
  publisher = {Department of Sports Medicine, Medical Faculty of Uludag University},
  address   = {Bursa},
  issn      = {1303-2968},
  pages     = {327 -- 336},
  year      = {2019},
  abstract  = {The purpose of this study was to examine the acute effects of short-term Achilles tendon vibration on plantar flexor torque, twitch contractile properties as well as muscle and cortical activity in young athletes. Eleven female elite soccer players aged 15.6 +/- 0.5 years participated in this study. Three different conditions were applied in randomized order: Achilles tendon vibration (80 Hz) for 30 and 300 s, and a passive control condition (300 s). Tests at baseline and following conditions included the assessment of peak plantar flexor torque during maximum voluntary contraction, electrically evoked muscle twitches (e.g., potentiated twitch peak torque [PT]), and electromyographic (EMG) activity of the plantar flexors. Additionally, electroencephalographic (EEG) activity of the primary motor and somatosensory cortex were assessed during a submaximal dynamic concentric-eccentric plantar flexion exercise using an elastic rubber band. Large-sized main effects of condition were found for EEG absolute alpha-1 and beta-1 band power (p <= 0.011; 1.5 <= d <= 2.6). Post-hoc tests indicated that alpha-1 power was significantly lower at 30 and 300 s (p = 0.009; d = 0.8) and beta-1 power significantly lower at 300 s (p < 0.001; d = 0.2) compared to control condition. No significant effect of condition was found for peak plantar flexor torque, electrical evoked muscle twitches, and EMG activity. In conclusion, short-term local Achilles tendon vibration induced lower brain activity (i.e., alpha-1 and beta-1 band power) but did not affect lower limb peak torque, twitch contractile properties, and muscle activity. Lower brain activity following short-term local Achilles tendon vibration may indicate improved cortical function during a submaximal dynamic exercise in female young soccer players.},
  language  = {en}
}
@article{BeckmannBeckerKadowetal.2019,
  author    = {Beckmann, Nadine and Becker, Katrin Anne and Kadow, Stephanie and Schumacher, Fabian and Kramer, Melanie and Kuehn, Claudine and Schulz-Schaeffer, Walter J. and Edwards, Michael J. and Kleuser, Burkhard and Gulbins, Erich and Carpinteiro, Alexander},
  title     = {Acid Sphingomyelinase Deficiency Ameliorates Farber Disease},
  series = {International journal of molecular sciences},
  volume    = {20},
  journal   = {International journal of molecular sciences},
  number    = {24},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms20246253},
  pages     = {18},
  year      = {2019},
  abstract  = {Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can't achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients.},
  language  = {en}
}
@article{GrafMorenodelasHerasRuizetal.2018,
  author    = {Graf, Lukas and Moreno-de-las-Heras, Mariano and Ruiz, Maurici and Calsamiglia, Aleix and Garc{\´i}a-Comendador, Juli{\´a}n and Fortesa, Josep and L{\´o}pez-Taraz{\´o}n, Jos{\´e} A. and Estrany, Joan},
  title     = {Accuracy assessment of digital terrain model dataset sources for hydrogeomorphological modelling in small mediterranean catchments},
  series = {Remote sensing},
  volume    = {10},
  journal   = {Remote sensing},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-4292},
  doi       = {10.3390/rs10122014},
  pages     = {26},
  year      = {2018},
  abstract  = {Digital terrain models (DTMs) are a fundamental source of information in Earth sciences. DTM-based studies, however, can contain remarkable biases if limitations and inaccuracies in these models are disregarded. In this work, four freely available datasets, including Shuttle Radar Topography Mission C-Band Synthetic Aperture Radar (SRTM C-SAR V3 DEM), Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Map (ASTER GDEM V2), and two nationwide airborne light detection and ranging (LiDAR)-derived DTMs (at 5-m and 1-m spatial resolution, respectively) were analysed in three geomorphologically contrasting, small (3-5 km2) catchments located in Mediterranean landscapes under intensive human influence (Mallorca Island, Spain). Vertical accuracy as well as the influence of each dataset's characteristics on hydrological and geomorphological modelling applicability were assessed by using ground-truth data, classic geometric and morphometric parameters, and a recently proposed index of sediment connectivity. Overall vertical accuracy—expressed as the root mean squared error (RMSE) and normalised median deviation (NMAD)—revealed the highest accuracy for the 1-m (RMSE = 1.55 m; NMAD = 0.44 m) and 5-m LiDAR DTMs (RMSE = 1.73 m; NMAD = 0.84 m). Vertical accuracy of the SRTM data was lower (RMSE = 6.98 m; NMAD = 5.27 m), but considerably higher than for the ASTER data (RMSE = 16.10 m; NMAD = 11.23 m). All datasets were affected by systematic distortions. Propagation of these errors and coarse horizontal resolution caused negative impacts on flow routing, stream network, and catchment delineation, and to a lower extent, on the distribution of slope values. These limitations should be carefully considered when applying DTMs for catchment hydrogeomorphological modelling.},
  language  = {en}
}
@article{Kulawiak2021,
  author    = {Kulawiak, Pawel R.},
  title     = {Academic benefits of wearing noise-cancelling headphones during class for typically developing students and students with special needs},
  series = {Cogent education},
  volume    = {8},
  journal   = {Cogent education},
  number    = {1},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {2331-186X},
  doi       = {10.1080/2331186X.2021.1957530},
  pages     = {21},
  year      = {2021},
  abstract  = {Classroom noise impairs students' cognition and learning. At a first glance, it seems useful to prevent the negative effects of noise on academic learning by wearing noise-cancelling (NC) headphones during class. The literature and guidelines emphasize the academic benefits of wearing NC headphones (decreased auditory distraction, increased concentration, learning improvement, and decreased distress). These benefits are particularly expected for students with special needs. None of the recommendations to wear NC headphones during class refer to any empirical studies, indicating a potential research gap and lack of evidence. Therefore, the question arises: Is there any empirical evidence supporting academic benefits of wearing NC headphones during class for typically developing students or students with special needs? A total of 13 empirical studies (quantitative and qualitative) were identified through a systematic scoping review of the existing literature. A wide range of outcomes (cognition, learning, academic performance, behaviour, and emotions) were reported related to the use of NC headphones. Most of the studies refer to specific groups of students with special needs (learning disabilities, autism, ADHD, etc.). In view of the limited number of studies, small sample sizes, and lack of replication studies, all studies give the impression of being pilot studies on the academic benefits of wearing NC headphones. The practice of wearing NC headphones during class is an understudied topic. The current body of evidence does not meet the standards for evidence-based practices in both general and special education. Implications for educational practice and future research are discussed.},
  language  = {en}
}
@article{GuggenbergerChechkinMetzler2022,
  author    = {Guggenberger, Tobias and Chechkin, Aleksei and Metzler, Ralf},
  title     = {Absence of stationary states and non-Boltzmann distributions of fractional Brownian motion in shallow external potentials},
  series = {New journal of physics : the open-access journal for physics},
  volume    = {24},
  journal   = {New journal of physics : the open-access journal for physics},
  number    = {7},
  publisher = {Dt. Physikalische Ges.},
  address   = {[Bad Honnef]},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ac7b3c},
  pages     = {18},
  year      = {2022},
  abstract  = {We study the diffusive motion of a particle in a subharmonic potential of the form U(x) = |x|( c ) (0 < c < 2) driven by long-range correlated, stationary fractional Gaussian noise xi ( alpha )(t) with 0 < alpha <= 2. In the absence of the potential the particle exhibits free fractional Brownian motion with anomalous diffusion exponent alpha. While for an harmonic external potential the dynamics converges to a Gaussian stationary state, from extensive numerical analysis we here demonstrate that stationary states for shallower than harmonic potentials exist only as long as the relation c > 2(1 - 1/alpha) holds. We analyse the motion in terms of the mean squared displacement and (when it exists) the stationary probability density function. Moreover we discuss analogies of non-stationarity of Levy flights in shallow external potentials.},
  language  = {en}
}
@article{GoswamiBoersRheinwaltetal.2018,
  author    = {Goswami, Bedartha and Boers, Niklas and Rheinwalt, Aljoscha and Marwan, Norbert and Heitzig, Jobst and Breitenbach, Sebastian Franz Martin and Kurths, J{\"u}rgen},
  title     = {Abrupt transitions in time series with uncertainties},
  series = {Nature Communications},
  volume    = {9},
  journal   = {Nature Communications},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-017-02456-6},
  pages     = {10},
  year      = {2018},
  abstract  = {Identifying abrupt transitions is a key question in various disciplines. Existing transition detection methods, however, do not rigorously account for time series uncertainties, often neglecting them altogether or assuming them to be independent and qualitatively similar. Here, we introduce a novel approach suited to handle uncertainties by representing the time series as a time-ordered sequence of probability density functions. We show how to detect abrupt transitions in such a sequence using the community structure of networks representing probabilities of recurrence. Using our approach, we detect transitions in global stock indices related to well-known periods of politico-economic volatility. We further uncover transitions in the El Ni{\~n}o-Southern Oscillation which coincide with periods of phase locking with the Pacific Decadal Oscillation. Finally, we provide for the first time an 'uncertainty-aware' framework which validates the hypothesis that ice-rafting events in the North Atlantic during the Holocene were synchronous with a weakened Asian summer monsoon.},
  language  = {en}
}
@article{DoeringGrigorievTapioetal.2021,
  author    = {Doering, Ulrike and Grigoriev, Dmitry and Tapio, Kosti and Rosencrantz, Sophia and Rosencrantz, Ruben R. and Bald, Ilko and B{\"o}ker, Alexander},
  title     = {About the mechanism of ultrasonically induced protein capsule formation},
  series = {RSC Advances : an international journal to further the chemical sciences / Royal Society of Chemistry},
  volume    = {11},
  journal   = {RSC Advances : an international journal to further the chemical sciences / Royal Society of Chemistry},
  number    = {27},
  publisher = {RSC Publishing},
  address   = {London},
  issn      = {2046-2069},
  doi       = {10.1039/d0ra08100k},
  pages     = {16152 -- 16157},
  year      = {2021},
  abstract  = {In this paper, we propose a consistent mechanism of protein microcapsule formation upon ultrasound treatment. Aqueous suspensions of bovine serum albumin (BSA) microcapsules filled with toluene are prepared by use of high-intensity ultrasound following a reported method. Stabilization of the oil-in-water emulsion by the adsorption of the protein molecules at the interface of the emulsion droplets is accompanied by the creation of the cross-linked capsule shell due to formation of intermolecular disulfide bonds caused by highly reactive species like superoxide radicals generated sonochemically. The evidence for this mechanism, which until now remained elusive and was not proven properly, is presented based on experimental data from SDS-PAGE, Raman spectroscopy and dynamic light scattering.},
  language  = {en}
}
@article{CortiCioniFranceschinietal.2019,
  author    = {Corti, Giacomo and Cioni, Raffaello and Franceschini, Zara and Sani, Federico and Scaillet, Stephane and Molin, Paola and Isola, Ilaria and Mazzarini, Francesco and Brune, Sascha and Keir, Derek and Erbello Doelesso, Asfaw and Muluneh, Ameha and Illsley-Kemp, Finnigan and Glerum, Anne},
  title     = {Aborted propagation of the Ethiopian rift caused by linkage with the Kenyan rift},
  series = {Nature Communications},
  volume    = {10},
  journal   = {Nature Communications},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-019-09335-2},
  pages     = {11},
  year      = {2019},
  abstract  = {Continental rift systems form by propagation of isolated rift segments that interact, and eventually evolve into continuous zones of deformation. This process impacts many aspects of rifting including rift morphology at breakup, and eventual ocean-ridge segmentation. Yet, rift segment growth and interaction remain enigmatic. Here we present geological data from the poorly documented Ririba rift (South Ethiopia) that reveals how two major sectors of the East African rift, the Kenyan and Ethiopian rifts, interact. We show that the Ririba rift formed from the southward propagation of the Ethiopian rift during the Pliocene but this propagation was short-lived and aborted close to the Pliocene-Pleistocene boundary. Seismicity data support the abandonment of laterally offset, overlapping tips of the Ethiopian and Kenyan rifts. Integration with new numerical models indicates that rift abandonment resulted from progressive focusing of the tectonic and magmatic activity into an oblique, throughgoing rift zone of near pure extension directly connecting the rift sectors.},
  language  = {en}
}
@article{CordonnierBovyBraun2019,
  author    = {Cordonnier, Guillaume and Bovy, Benoit and Braun, Jean},
  title     = {A versatile, linear complexity algorithm for flow routing in topographies with depressions},
  series = {Earth surface dynamics},
  volume    = {7},
  journal   = {Earth surface dynamics},
  number    = {2},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {2196-6311},
  doi       = {10.5194/esurf-7-549-2019},
  pages     = {549 -- 562},
  year      = {2019},
  abstract  = {We present a new algorithm for solving the common problem of flow trapped in closed depressions within digital elevation models, as encountered in many applications relying on flow routing. Unlike other approaches (e.g., the Priority-Flood depression filling algorithm), this solution is based on the explicit computation of the flow paths both within and across the depressions through the construction of a graph connecting together all adjacent drainage basins. Although this represents many operations, a linear time complexity can be reached for the whole computation, making it very efficient. Compared to the most optimized solutions proposed so far, we show that this algorithm of flow path enforcement yields the best performance when used in landscape evolution models. In addition to its efficiency, our proposed method also has the advantage of letting the user choose among different strategies of flow path enforcement within the depressions (i.e., filling vs. carving). Furthermore, the computed graph of basins is a generic structure that has the potential to be reused for solving other problems as well, such as the simulation of erosion. This sequential algorithm may be helpful for those who need to, e.g., process digital elevation models of moderate size on single computers or run batches of simulations as part of an inference study.},
  language  = {en}
}
@misc{FrankKreitz2018,
  author    = {Frank, Mario and Kreitz, Christoph},
  title     = {A theorem prover for scientific and educational purposes},
  series = {Electronic proceedings in theoretical computer science},
  journal   = {Electronic proceedings in theoretical computer science},
  number    = {267},
  publisher = {Open Publishing Association},
  address   = {Sydney},
  issn      = {2075-2180},
  doi       = {10.4204/EPTCS.267.4},
  pages     = {59 -- 69},
  year      = {2018},
  abstract  = {We present a prototype of an integrated reasoning environment for educational purposes. The presented tool is a fragment of a proof assistant and automated theorem prover. We describe the existing and planned functionality of the theorem prover and especially the functionality of the educational fragment. This currently supports working with terms of the untyped lambda calculus and addresses both undergraduate students and researchers. We show how the tool can be used to support the students' understanding of functional programming and discuss general problems related to the process of building theorem proving software that aims at supporting both research and education.},
  language  = {en}
}
@article{PradhanCostaRybskietal.2017,
  author    = {Pradhan, Prajal and Costa, Lu{\´i}s F{\´i}l{\´i}pe Carvalho da and Rybski, Diego and Lucht, Wolfgang and Kropp, J{\"u}rgen},
  title     = {A Systematic Study of Sustainable Development Goal (SDG) Interactions},
  series = {Earths Future},
  volume    = {5},
  journal   = {Earths Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000632},
  pages     = {1169 -- 1179},
  year      = {2017},
  abstract  = {Sustainable development goals (SDGs) have set the 2030 agenda to transform our world by tackling multiple challenges humankind is facing to ensure well-being, economic prosperity, and environmental protection. In contrast to conventional development agendas focusing on a restricted set of dimensions, the SDGs provide a holistic and multidimensional view on development. Hence, interactions among the SDGs may cause diverging results. To analyze the SDG interactions we systematize the identification of synergies and trade-offs using official SDG indicator data for 227 countries. A significant positive correlation between a pair of SDG indicators is classified as a synergy while a significant negative correlation is classified as a trade-off. We rank synergies and trade-offs between SDGs pairs on global and country scales in order to identify the most frequent SDG interactions. For a given SDG, positive correlations between indicator pairs were found to outweigh the negative ones in most countries. Among SDGs the positive and negative correlations between indicator pairs allowed for the identification of particular global patterns. SDG 1 (No poverty) has synergetic relationship with most of the other goals, whereas SDG 12 (Responsible consumption and production) is the goal most commonly associated with trade-offs. The attainment of the SDG agenda will greatly depend on whether the identified synergies among the goals can be leveraged. In addition, the highlighted trade-offs, which constitute obstacles in achieving the SDGs, need to be negotiated and made structurally nonobstructive by deeper changes in the current strategies.},
  language  = {en}
}