@article{Mikolajczyk2017,
  author    = {Mikolajczyk, Aniela Maria},
  title     = {Alexander von Humboldts Manuskript Isle de Cube},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/248},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395773},
  pages     = {58 -- 79},
  year      = {2017},
  abstract  = {Das von Alexander von Humboldt ab 1804 oder sp{\"a}ter verfasste Manuskript „Isle de Cube. Antilles en g{\´e}n{\´e}ral" wurde erst k{\"u}rzlich zum ersten Mal ver{\"o}ffentlicht. Es stellt die Grundlage f{\"u}r den Essai politique sur l'{\^i}le de Cuba (1826) dar, der als das „wichtigste liberale Manifest des 19. Jahrhunderts gegen die Sklaverei" gilt. Ziel der Untersuchung ist, die textgenetische inhaltliche und stilistische Entwicklung vom Manuskript zur Publikation ansatzweise nachverfolgen zu k{\"o}nnen, um R{\"u}ckschl{\"u}sse auf Humboldts Arbeitsweise und Strategien als Autor mit einem politischen Anliegen zu ziehen.},
  language  = {de}
}
@article{Leitner2017,
  author    = {Leitner, Ulrike},
  title     = {Sobre r{\´i}os y canales},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/251},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395769},
  pages     = {29 -- 57},
  year      = {2017},
  abstract  = {Anhand von unpublizierten Beispielen aus dem Nachlass Humboldts soll ein wichtiger Aspekt seiner Reise vorgestellt werden: Nach seinen Messungen, berechnete er die Ergebnisse mit mathematischen Methoden, zeichnete Karten und verglich diese mit denen seiner Vorg{\"a}nger. Sp{\"a}ter publizierte er Karten von hoher Qualit{\"a}t und gab zur Vervollst{\"a}ndigung anderen Reisenden Ratschl{\"a}ge, um in Regionen zu messen, die er nicht selbst besucht hatte. Humboldts Nachlass widerspiegelt die Informationen von Reisenden, H{\"a}ndlern und Wissenschaftlern, die Humboldt benutzte. Mit der Unabh{\"a}ngigkeit wuchs das Interesse der lateinamerikanischen L{\"a}nder an einem Austausch mit Europa. Mit dem Kolumbianer Joaqu{\´i}n Acosta entwickelte sich ein gegenseitiger Austausch z. B. {\"u}ber die Region Choc{\´o}, die f{\"u}r den Bergbau von Gold und Platin, sowie f{\"u}r die interozeanische Verbindung von großem Interesse war.},
  language  = {es}
}
@article{DrozdowskaBroering2017,
  author    = {Drozdowska-Broering, Izabela},
  title     = {Alexander von Humboldt und die polnische Wissenschafts- und Kulturwelt},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/249},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395750},
  pages     = {16 -- 28},
  year      = {2017},
  abstract  = {Alexander von Humboldt war in Polen bereits im ausgehenden 18. Jahrhundert ber{\"u}hmt geworden. Er reiste mehrmals nach Polen und unterhielt Kontakte zu polnischen oder polnischst{\"a}mmigen Wissenschaftlern. Aus den 30er und 40er Jahren stammen die meisten schriftlichen Belege, die von Beziehungen Humboldts zu solchen Pers{\"o}nlichkeiten wie Ludwik Zejszner, J{\´o}zef Waraszkiewicz oder Filip Neryusz Walter zeugen. Nicht nachweisbar ist heute daf{\"u}r Humboldts Kontakt zu Wincenty Pol sowie zu Ignacy Domeyko. Humboldt inspiriert nicht nur polnische Wissenschaftler, sondern auch f{\"u}hrende polnische Dichter der Romantik. Viele polnische Exilanten verdanken dem deutschen Gelehrten wertvolle Kontakte, Empfehlungsschreiben und Gesuche bei damaligen Machthabern.},
  language  = {de}
}
@article{Paessler2017,
  author    = {P{\"a}ßler, Ulrich},
  title     = {A Political Economy of Nature},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/252},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395781},
  pages     = {80 -- 91},
  year      = {2017},
  abstract  = {In seinem Aufsatz „Ueber die Schwankungen der Goldproduktion mit R{\"u}cksicht auf staatswirthschaftliche Probleme" (1838) entfaltet Alexander von Humboldt auf wenigen Seiten eine Weltgeschichte des Edelmetallverkehrs von der Antike bis ins 19. Jahrhundert. Der vorliegende Artikel geht Humboldts {\"o}konomischem Denken als Teil seiner Forschungen zur Natur- und Menschheitsgeschichte nach. Er beginnt mit einem kurzen Abriss der von sp{\"a}tmerkantilistischen und fr{\"u}hliberalen Einfl{\"u}ssen gepr{\"a}gten Ausbildung Humboldts. Der Artikel diskutiert anschließend eine von Humboldt angefertigte Weltkarte sowie vier darauf bezogene Schaubilder, die historische und zeitgen{\"o}ssische statistische Daten zur graphischen Vision eines globalen Wirtschaftskreislaufs kombinieren. In einem weiteren Schritt geht der Artikel Humboldts Anwendung historischer und naturgeschichtlicher Forschungsmethoden auf dem Gebiet der politischen {\"O}konomie am Beispiel des Aufsatzes von 1838 nach. Den Schluss der Untersuchung bildet Humboldts Auseinandersetzung mit dem Edelmetall Platin, dessen begrenzte Verbreitung im Widerspruch zur Idee eines freien weltweiten Austauschs stand.},
  language  = {en}
}
@article{Schwarz2017,
  author    = {Schwarz, Ingo},
  title     = {"Any American will always be welcome to the study of Alexander von Humboldt"},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/250},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395798},
  pages     = {92 -- 95},
  year      = {2017},
  abstract  = {Im Jahr 1836 traf der US-amerikanische Geistliche und Sammler historischer Dokumente William B. Sprague (1795-1876) w{\"a}hrend seines zweiten Europabesuches auch mit Alexander von Humboldt in Berlin zusammen. Im Verlaufe des Gespr{\"a}ches zeigte sich Humboldt mit den politischen Entwicklungen in den Vereinigten Staaten bestens vertraut. Er kritisierte das Sklavensystem, r{\"a}umte aber auch ein, dass er viele Aspekte der amerikanischen Demokratie bewunderte.},
  language  = {de}
}
@article{Schwarz2017,
  author    = {Schwarz, Ingo},
  title     = {Bernd K{\"o}lbel: Geologe und Alexander-von-Humboldt-Forscher},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/253},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395836},
  pages     = {167 -- 170},
  year      = {2017},
  abstract  = {Nachruf mit Bibliographie.},
  language  = {de}
}
@article{Schwarz2017,
  author    = {Schwarz, Ingo},
  title     = {Nachtrag zu HiN XVII, 33 (2016)},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/255},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395824},
  pages     = {166 -- 167},
  year      = {2017},
  language  = {de}
}
@article{Werner2017,
  author    = {Werner, Petra},
  title     = {Franz Julius Ferdinand Meyen: gef{\"o}rdert und fr{\"u}hvollendet},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/247},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395819},
  pages     = {147 -- 164},
  year      = {2017},
  abstract  = {Franz Ferdinand Julius Meyen (1804-1840) ver{\"o}ffentlichte auf sehr vielen Gebieten der Biologie wichtige Arbeiten, vor allem in Botanik und Zoologie. Mit Unterst{\"u}tzung Alexander von Humboldts gelang es ihm, auf dem Forschungsschiff „Prinzess Louise" anzuheuern und als Schiffsarzt an einer mehrj{\"a}hrigen Weltreise teilzunehmen. Humboldt, der einige Regionen ebenfalls besucht und erforscht hatte, unterst{\"u}tzte seinen jungen Kollegen bei der Vorbereitung seiner Reise. Meyen ver{\"o}ffentlichte seine Reiseergebnisse bereits kurz nach seiner R{\"u}ckkehr, gef{\"o}rdert von Christian Gottfried Nees von Esenbeck (1776-1858), sowohl als zweiteiligen historischen Reisebericht als auch in sieben Einzelabhandlungen. Einige Ergebnisse, die er, schwerkrank, nicht selbst verwerten konnte, {\"u}bergab er noch bei Lebzeiten zur Bearbeitung an Spezialisten, andere wurden posthum von Mitgliedern der Leopoldina publiziert. Meyen brachte u. a. eine umfangreiche Sammlung an Vogelpr{\"a}paraten mit, zu denen auch das Erstbeschreibungsexemplar des von ihm so genannten Spheniscus humboldti (Trivialname: Humboldt-Pinguin) geh{\"o}rt.},
  language  = {de}
}
@article{ZimmermannRaschkeEppetal.2017,
  author    = {Zimmermann, Heike Hildegard and Raschke, Elena and Epp, Laura Saskia and Stoof-Leichsenring, Kathleen Rosemarie and Schirrmeister, Lutz and Schwamborn, Georg and Herzschuh, Ulrike},
  title     = {The history of tree and shrub taxa on Bol'shoy Lyakhovsky Island (New Siberian Archipelago) since the Last Interglacial Uncovered by Sedimentary Ancient DNA and Pollen Data},
  series = {Genes},
  volume    = {8},
  journal   = {Genes},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4425},
  doi       = {10.3390/genes8100273},
  pages     = {273},
  year      = {2017},
  abstract  = {Ecosystem boundaries, such as the Arctic-Boreal treeline, are strongly coupled with climate and were spatially highly dynamic during past glacial-interglacial cycles. Only a few studies cover vegetation changes since the last interglacial, as most of the former landscapes are inundated and difficult to access. Using pollen analysis and sedimentary ancient DNA (sedaDNA) metabarcoding, we reveal vegetation changes on Bol'shoy Lyakhovsky Island since the last interglacial from permafrost sediments. Last interglacial samples depict high levels of floral diversity with the presence of trees (Larix, Picea, Populus) and shrubs (Alnus, Betula, Ribes, Cornus, Saliceae) on the currently treeless island. After the Last Glacial Maximum, Larix re-colonised the island but disappeared along with most shrub taxa. This was probably caused by Holocene sea-level rise, which led to increased oceanic conditions on the island. Additionally, we applied two newly developed larch-specific chloroplast markers to evaluate their potential for tracking past population dynamics from environmental samples. The novel markers were successfully re-sequenced and exhibited two variants of each marker in last interglacial samples. SedaDNA can track vegetation changes as well as genetic changes across geographic space through time and can improve our understanding of past processes that shape modern patterns.},
  language  = {en}
}
@article{BernacchioniGhiniCencettietal.2017,
  author    = {Bernacchioni, Caterina and Ghini, Veronica and Cencetti, Francesca and Japtok, Lukasz and Donati, Chiara and Bruni, Paola and Turano, Paola},
  title     = {NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells},
  series = {Molecular oncology / Federation of European Biochemical Societies},
  volume    = {11},
  journal   = {Molecular oncology / Federation of European Biochemical Societies},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1878-0261},
  doi       = {10.1002/1878-0261.12048},
  pages     = {517 -- 533},
  year      = {2017},
  abstract  = {Strong experimental evidence in animal and cellular models supports a pivotal role of sphingosine kinase-1 (SK1) in oncogenesis. In many human cancers, SK1 levels are upregulated and these increases are linked to poor prognosis in patients. Here, by employing untargeted NMR- based metabolomic profiling combined with functional validations, we report the crucial role of SK1 in the metabolic shift known as the Warburg effect in A2780 ovarian cancer cells. Indeed, expression of SK1 induced a high glycolytic rate, characterized by increased levels of lactate along with increased expression of the proton/monocarboxylate symporter MCT1, and decreased oxidative metabolism, associated with the accumulation of intermediates of the tricarboxylic acid cycle and reduction in CO2 production. Additionally, SK1-expressing cells displayed a significant increase in glucose uptake paralleled by GLUT3 transporter upregulation. The role of SK1 is not limited to the induction of aerobic glycolysis, affecting metabolic pathways that appear to support the biosynthesis of macromolecules. These findings highlight the role of SK1 signaling axis in cancer metabolic reprogramming, pointing out innovative strategies for cancer therapies.},
  language  = {en}
}
@article{HintscheWaljorGrossmannetal.2017,
  author    = {Hintsche, Marius and Waljor, Veronika and Grossmann, Robert and K{\"u}hn, Marco J. and Thormann, Kai M. and Peruani, Fernando and Beta, Carsten},
  title     = {A polar bundle of flagella can drive bacterial swimming by pushing, pulling, or coiling around the cell body},
  series = {Scientific reports},
  volume    = {7},
  journal   = {Scientific reports},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-16428-9},
  pages     = {10},
  year      = {2017},
  abstract  = {Bacteria swim in sequences of straight runs that are interrupted by turning events. They drive their swimming locomotion with the help of rotating helical flagella. Depending on the number of flagella and their arrangement across the cell body, different run-and-turn patterns can be observed. Here, we present fluorescence microscopy recordings showing that cells of the soil bacterium Pseudomonas putida that are decorated with a polar tuft of helical flagella, can alternate between two distinct swimming patterns. On the one hand, they can undergo a classical push-pull-push cycle that is well known from monopolarly flagellated bacteria but has not been reported for species with a polar bundle of multiple flagella. Alternatively, upon leaving the pulling mode, they can enter a third slow swimming phase, where they propel themselves with their helical bundle wrapped around the cell body. A theoretical estimate based on a random-walk model shows that the spreading of a population of swimmers is strongly enhanced when cycling through a sequence of pushing, pulling, and wrapped flagellar configurations as compared to the simple push-pull-push pattern.},
  language  = {en}
}
@article{FrielerSchaubergerArnethetal.2017,
  author    = {Frieler, Katja and Schauberger, Bernhard and Arneth, Almut and Balkovic, Juraj and Chryssanthacopoulos, James and Deryng, Delphine and Elliott, Joshua and Folberth, Christian and Khabarov, Nikolay and M{\"u}ller, Christoph and Olin, Stefan and Pugh, Thomas A. M. and Schaphoff, Sibyll and Schewe, Jacob and Schmid, Erwin and Warszawski, Lila and Levermann, Anders},
  title     = {Understanding the weather signal in national crop-yield variability},
  series = {Earths future},
  volume    = {5},
  journal   = {Earths future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2016EF000525},
  pages     = {605 -- 616},
  year      = {2017},
  abstract  = {Year-to-year variations in crop yields can have major impacts on the livelihoods of subsistence farmers and may trigger significant global price fluctuations, with severe consequences for people in developing countries. Fluctuations can be induced by weather conditions, management decisions, weeds, diseases, and pests. Although an explicit quantification and deeper understanding of weather-induced crop-yield variability is essential for adaptation strategies, so far it has only been addressed by empirical models. Here, we provide conservative estimates of the fraction of reported national yield variabilities that can be attributed to weather by state-of-the-art, process-based crop model simulations. We find that observed weather variations can explain more than 50\% of the variability in wheat yields in Australia, Canada, Spain, Hungary, and Romania. For maize, weather sensitivities exceed 50\% in seven countries, including the United States. The explained variance exceeds 50\% for rice in Japan and South Korea and for soy in Argentina. Avoiding water stress by simulating yields assuming full irrigation shows that water limitation is a major driver of the observed variations in most of these countries. Identifying the mechanisms leading to crop-yield fluctuations is not only fundamental for dampening fluctuations, but is also important in the context of the debate on the attribution of loss and damage to climate change. Since process-based crop models not only account for weather influences on crop yields, but also provide options to represent human-management measures, they could become essential tools for differentiating these drivers, and for exploring options to reduce future yield fluctuations.},
  language  = {en}
}
@article{MahataPandayRupakhetietal.2017,
  author    = {Mahata, Khadak Singh and Panday, Arnico Kumar and Rupakheti, Maheswar and Singh, Ashish and Naja, Manish and Lawrence, Mark},
  title     = {Seasonal and diurnal variations in methane and carbon dioxide in the Kathmandu Valley in the foothills of the central Himalayas},
  series = {Atmospheric Chemistry and Physics},
  volume    = {17},
  journal   = {Atmospheric Chemistry and Physics},
  number    = {20},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1680-7316},
  doi       = {10.5194/acp-17-12573-2017},
  pages     = {12573 -- 12596},
  year      = {2017},
  abstract  = {The SusKat-ABC (Sustainable Atmosphere for the Kathmandu Valley-Atmospheric Brown Clouds) international air pollution measurement campaign was carried out from December 2012 to June 2013 in the Kathmandu Valley and surrounding regions in Nepal. The Kathmandu Valley is a bowl-shaped basin with a severe air pollution problem. This paper reports measurements of two major greenhouse gases (GHGs), methane (CH4) and carbon dioxide (CO2), along with the pollutant CO, that began during the campaign and were extended for 1 year at the SusKat-ABC supersite in Bode, a semi-urban location in the Kathmandu Valley. Simultaneous measurements were also made during 2015 in Bode and a nearby rural site (Chanban) similar to 25 km (aerial distance) to the southwest of Bode on the other side of a tall ridge. The ambient mixing ratios of methane (CH4), carbon dioxide (CO2), water vapor, and carbon monoxide (CO) were measured with a cavity ring-down spectrometer (G2401; Picarro, USA) along with meteorological parameters for 1 year (March 2013-March 2014). These measurements are the first of their kind in the central Himalayan foothills. At Bode, the annual average mixing ratios of CO2 and CH4 were 419.3 (+/- 6.0) ppm and 2.192 (+/- 0.066) ppm, respectively. These values are higher than the levels observed at background sites such as Mauna Loa, USA (CO2: 396.8 +/- 2.0 ppm, CH4: 1.831 +/- 0.110 ppm) and Waliguan, China (CO2: 397.7 +/- 3.6 ppm, CH4: 1.879 +/- 0.009 ppm) during the same period and at other urban and semi-urban sites in the region, such as Ahmedabad and Shadnagar (India). They varied slightly across the seasons at Bode, with seasonal average CH4 mixing ratios of 2.157 (+/- 0.230) ppm in the pre-monsoon season, 2.199 (+/- 0.241) ppm in the monsoon, 2.210 (+/- 0.200) ppm in the post-monsoon, and 2.214 (+/- 0.209) ppm in the winter season. The average CO2 mixing ratios were 426.2 (+/- 25.5) ppm in the pre-monsoon, 413.5 (+/- 24.2) ppm in the monsoon, 417.3 (+/- 23.1) ppm in the postmonsoon, and 421.9 (+/- 20.3) ppm in the winter season. The maximum seasonal mean mixing ratio of CH4 in winter was only 0.057 ppm or 2.6\% higher than the seasonal minimum during the pre-monsoon period, while CO2 was 12.8 ppm or 3.1\% higher during the pre-monsoon period (seasonal maximum) than during the monsoon (seasonal minimum). On the other hand, the CO mixing ratio at Bode was 191\% higher during the winter than during the monsoon season. The enhancement in CO2 mixing ratios during the pre-monsoon season is associated with additional CO2 emissions from forest fires and agro-residue burning in northern South Asia in addition to local emissions in the Kathmandu Valley. Published CO = CO2 ratios of different emission sources in Nepal and India were compared with the observed CO = CO2 ratios in this study. This comparison suggested that the major sources in the Kathmandu Valley were residential cooking and vehicle exhaust in all seasons except winter. In winter, brick kiln emissions were a major source. Simultaneous measurements in Bode and Chanban (15 July-3 October 2015) revealed that the mixing ratios of CO2, CH4, and CO were 3.8, 12, and 64\% higher in Bode than Chanban. The Kathmandu Valley thus has significant emissions from local sources, which can also be attributed to its bowl-shaped geography that is conducive to pollution build-up. At Bode, all three gas species (CO2, CH4, and CO) showed strong diurnal patterns in their mixing ratios with a pronounced morning peak (ca. 08:00), a dip in the afternoon, and a gradual increase again through the night until the next morning. CH4 and CO at Chanban, however, did not show any noticeable diurnal variations. These measurements provide the first insights into the diurnal and seasonal variation in key greenhouse gases and air pollutants and their local and regional sources, which is important information for atmospheric research in the region.},
  language  = {en}
}
@article{WiesmeierDalinWehrleetal.2017,
  author    = {Wiesmeier, Isabella K. and Dalin, Daniela and Wehrle, Anja and Granacher, Urs and Muehlbauer, Thomas and Dietterle, J{\"o}rg and Weiller, Cornelius and Gollhofer, Albert and Maurer, Christoph},
  title     = {Balance training enhances vestibular function and reduces overactive proprioceptive feedback in elderly},
  series = {Frontiers in aging neuroscience},
  volume    = {9},
  journal   = {Frontiers in aging neuroscience},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1663-4365},
  doi       = {10.3389/fnagi.2017.00273},
  pages     = {13},
  year      = {2017},
  abstract  = {Objectives: Postural control in elderly people is impaired by degradations of sensory, motor, and higher-level adaptive mechanisms. Here, we characterize the effects of a progressive balance training programon these postural control impairments using a brain network model based on system identification techniques. Methods and Material: We analyzed postural control of 35 healthy elderly subjects and compared findings to data from 35 healthy young volunteers. Eighteen elderly subjects performed a 10 week balance training conducted twice per week. Balance training was carried out in static and dynamic movement states, on support surfaces with different elastic compliances, under different visual conditions and motor tasks. Postural control was characterized by spontaneous sway and postural reactions to pseudorandom anterior-posterior tilts of the support surface. Data were interpreted using a parameter identification procedure based on a brain network model. Conclusion: Balance training reduced overactive proprioceptive feedback and restored vestibular orientation in elderly. Based on the assumption of a linear deterioration of postural control across the life span, the training effect can be extrapolated as a juvenescence of 10 years. This study points to a considerable benefit of a continuous balance training in elderly, even without any sensorimotor deficits.},
  language  = {en}
}
@article{OrtizAmezcuaGuerreroRascadoJoseGranadosMunozetal.2017,
  author    = {Ortiz-Amezcua, Pablo and Guerrero-Rascado, Juan Luis and Jose Granados-Munoz, Maria and Benavent-Oltra, Jose Antonio and B{\"o}ckmann, Christine and Samaras, Stefanos and Stachlewska, Iwona Sylwia and Janicka, Lucja and Baars, Holger and Bohlmann, Stephanie and Alados-Arboledas, Lucas},
  title     = {Microphysical characterization of long-range transported biomass burning particles from North America at three EARLINET stations},
  series = {Atmospheric Chemistry and Physics},
  volume    = {17},
  journal   = {Atmospheric Chemistry and Physics},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1680-7316},
  doi       = {10.5194/acp-17-5931-2017},
  pages     = {5931 -- 5946},
  year      = {2017},
  abstract  = {Strong events of long-range transported biomass burning aerosol were detected during July 2013 at three EARLINET (European Aerosol Research Lidar Network) stations, namely Granada (Spain), Leipzig (Germany) and Warsaw (Poland). Satellite observations from MODIS (Moderate Resolution Imaging Spectroradiometer) and CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization) instruments, as well as modeling tools such as HYSPLIT (Hybrid Single-Particle Lagrangian Integrated Trajectory) and NAAPS (Navy Aerosol Analysis and Prediction System), have been used to estimate the sources and transport paths of those North American forest fire smoke particles. A multiwavelength Raman lidar technique was applied to obtain vertically resolved particle optical properties, and further inversion of those properties with a regularization algorithm allowed for retrieving microphysical information on the studied particles. The results highlight the presence of smoke layers of 1-2 km thickness, located at about 5 km a.s.l. altitude over Granada and Leipzig and around 2.5 km a.s.l. at Warsaw. These layers were intense, as they accounted for more than 30\% of the total AOD (aerosol optical depth) in all cases, and presented optical and microphysical features typical for different aging degrees: color ratio of lidar ratios (LR532/LR355) around 2, alpha-related angstrom exponents of less than 1, effective radii of 0.3 mu m and large values of single scattering albedos (SSA), nearly spectrally independent. The intensive microphysical properties were compared with columnar retrievals form co-located AERONET (Aerosol Robotic Network) stations. The intensity of the layers was also characterized in terms of particle volume concentration, and then an experimental relationship between this magnitude and the particle extinction coefficient was established.},
  language  = {en}
}
@article{WachsBilzFischeretal.2017,
  author    = {Wachs, Sebastian and Bilz, Ludwig and Fischer, Saskia M. and Wright, Michelle F.},
  title     = {Do emotional components of alexithymia mediate the interplay between cyberbullying victimization and perpetration?},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {14},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph14121530},
  pages     = {11},
  year      = {2017},
  abstract  = {A substantial amount of research has revealed that cyberbully-victims have more emotional and behavioral problems than either cyberbullying victims or perpetrators. However, until now, little research has been conducted into the factors that contribute to the interplay between cyberbullying victimization and perpetration. The purpose of this study was to examine the relationship between cyberbullying victimization, perpetration, and two emotional components of alexithymia, namely difficulties in identifying and describing one's own feelings. Self-report questions were administered to 1549 adolescents between 12 and 18 years old (M = 14.51; SD = 1.68; 42.1\% (n = 652) male) from Germany and Thailand. Results showed that cyberbullying victimization and alexithymia are associated with cyberbullying perpetration. Moreover, alexithymia mediated the associations between cyberbullying victimization and adolescents' cyberbullying perpetration. Consequently, we suggest that the ability to describe and identify one's own feelings might be important for understanding the link between cyberbullying, victimization, and perpetration. The results may help develop prevention and intervention programs focused on reducing cyberbullying.},
  language  = {en}
}
@article{KreibichDiBaldassarreVorogushynetal.2017,
  author    = {Kreibich, Heidi and Di Baldassarre, Giuliano and Vorogushyn, Sergiy and Aerts, Jeroen C. J. H. and Apel, Heiko and Aronica, Giuseppe T. and Arnbjerg-Nielsen, Karsten and Bouwer, Laurens M. and Bubeck, Philip and Caloiero, Tommaso and Chinh, Do T. and Cortes, Maria and Gain, Animesh K. and Giampa, Vincenzo and Kuhlicke, Christian and Kundzewicz, Zbigniew W. and Llasat, Maria Carmen and Mard, Johanna and Matczak, Piotr and Mazzoleni, Maurizio and Molinari, Daniela and Dung, Nguyen V. and Petrucci, Olga and Schr{\"o}ter, Kai and Slager, Kymo and Thieken, Annegret and Ward, Philip J. and Merz, Bruno},
  title     = {Adaptation to flood risk},
  series = {Earth's Future},
  volume    = {5},
  journal   = {Earth's Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000606},
  pages     = {953 -- 965},
  year      = {2017},
  abstract  = {As flood impacts are increasing in large parts of the world, understanding the primary drivers of changes in risk is essential for effective adaptation. To gain more knowledge on the basis of empirical case studies, we analyze eight paired floods, that is, consecutive flood events that occurred in the same region, with the second flood causing significantly lower damage. These success stories of risk reduction were selected across different socioeconomic and hydro-climatic contexts. The potential of societies to adapt is uncovered by describing triggered societal changes, as well as formal measures and spontaneous processes that reduced flood risk. This novel approach has the potential to build the basis for an international data collection and analysis effort to better understand and attribute changes in risk due to hydrological extremes in the framework of the IAHSs Panta Rhei initiative. Across all case studies, we find that lower damage caused by the second event was mainly due to significant reductions in vulnerability, for example, via raised risk awareness, preparedness, and improvements of organizational emergency management. Thus, vulnerability reduction plays an essential role for successful adaptation. Our work shows that there is a high potential to adapt, but there remains the challenge to stimulate measures that reduce vulnerability and risk in periods in which extreme events do not occur.},
  language  = {en}
}
@article{WurzbacherFuchsAttermeyeretal.2017,
  author    = {Wurzbacher, Christian and Fuchs, Andrea and Attermeyer, Katrin and Frindte, Katharina and Grossart, Hans-Peter and Hupfer, Michael and Casper, Peter and Monaghan, Michael T.},
  title     = {Shifts among Eukaryota, Bacteria, and Archaea define the vertical organization of a lake sediment},
  series = {Microbiome},
  volume    = {5},
  journal   = {Microbiome},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2049-2618},
  doi       = {10.1186/s40168-017-0255-9},
  pages     = {16},
  year      = {2017},
  abstract  = {Background: Lake sediments harbor diverse microbial communities that cycle carbon and nutrients while being constantly colonized and potentially buried by organic matter sinking from the water column. The interaction of activity and burial remained largely unexplored in aquatic sediments. We aimed to relate taxonomic composition to sediment biogeochemical parameters, test whether community turnover with depth resulted from taxonomic replacement or from richness effects, and to provide a basic model for the vertical community structure in sediments. Methods: We analyzed four replicate sediment cores taken from 30-m depth in oligo-mesotrophic Lake Stechlin in northern Germany. Each 30-cm core spanned ca. 170 years of sediment accumulation according to Cs-137 dating and was sectioned into layers 1-4 cm thick. We examined a full suite of biogeochemical parameters and used DNA metabarcoding to examine community composition of microbial Archaea, Bacteria, and Eukaryota. Results: Community beta-diversity indicated nearly complete turnover within the uppermost 30 cm. We observed a pronounced shift from Eukaryota- and Bacteria-dominated upper layers (<5 cm) to Bacteria-dominated intermediate layers (5-14 cm) and to deep layers (>14 cm) dominated by enigmatic Archaea that typically occur in deep-sea sediments. Taxonomic replacement was the prevalent mechanism in structuring the community composition and was linked to parameters indicative of microbial activity (e.g., CO2 and CH4 concentration, bacterial protein production). Richness loss played a lesser role but was linked to conservative parameters (e.g., C, N, P) indicative of past conditions. Conclusions: By including all three domains, we were able to directly link the exponential decay of eukaryotes with the active sediment microbial community. The dominance of Archaea in deeper layers confirms earlier findings from marine systems and establishes freshwater sediments as a potential low-energy environment, similar to deep sea sediments. We propose a general model of sediment structure and function based on microbial characteristics and burial processes. An upper "replacement horizon" is dominated by rapid taxonomic turnover with depth, high microbial activity, and biotic interactions. A lower "depauperate horizon" is characterized by low taxonomic richness, more stable "low-energy" conditions, and a dominance of enigmatic Archaea.},
  language  = {en}
}
@article{WichaHuisingaKloft2017,
  author    = {Wicha, Sebastian G. and Huisinga, Wilhelm and Kloft, Charlotte},
  title     = {Translational pharmacometric evaluation of typical antibiotic broad-spectrum combination therapies against staphylococcus aureus exploiting in vitro information},
  series = {CPT: pharmacometrics \& systems pharmacology},
  volume    = {6},
  journal   = {CPT: pharmacometrics \& systems pharmacology},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2163-8306},
  doi       = {10.1002/psp4.12197},
  pages     = {512 -- 522},
  year      = {2017},
  abstract  = {Broad-spectrum antibiotic combination therapy is frequently applied due to increasing resistance development of infective pathogens. The objective of the present study was to evaluate two common empiric broad-spectrum combination therapies consisting of either linezolid (LZD) or vancomycin (VAN) combined with meropenem (MER) against Staphylococcus aureus (S. aureus) as the most frequent causative pathogen of severe infections. A semimechanistic pharmacokinetic-pharmacodynamic (PK-PD) model mimicking a simplified bacterial life-cycle of S. aureus was developed upon time-kill curve data to describe the effects of LZD, VAN, and MER alone and in dual combinations. The PK-PD model was successfully (i) evaluated with external data from two clinical S. aureus isolates and further drug combinations and (ii) challenged to predict common clinical PK-PD indices and breakpoints. Finally, clinical trial simulations were performed that revealed that the combination of VAN-MER might be favorable over LZD-MER due to an unfavorable antagonistic interaction between LZD and MER.},
  language  = {en}
}
@article{EhmannZollerMinichmayretal.2017,
  author    = {Ehmann, Lisa and Zoller, Michael and Minichmayr, Iris K. and Scharf, Christina and Maier, Barbara and Schmitt, Maximilian V. and Hartung, Niklas and Huisinga, Wilhelm and Vogeser, Michael and Frey, Lorenz and Zander, Johannes and Kloft, Charlotte},
  title     = {Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients},
  series = {Critical care},
  volume    = {21},
  journal   = {Critical care},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1466-609X},
  doi       = {10.1186/s13054-017-1829-4},
  pages     = {14},
  year      = {2017},
  abstract  = {Background: Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically ill patients. The objective of this study was to investigate the target attainment of standard meropenem dosing in a heterogeneous critically ill population, to quantify the impact of the full renal function spectrum on meropenem exposure and target attainment, and ultimately to translate the findings into a tool for practical application. Methods: A prospective observational single-centre study was performed with critically ill patients with severe infections receiving standard dosing of meropenem. Serial blood samples were drawn over 4 study days to determine meropenem serum concentrations. Renal function was assessed by creatinine clearance according to the Cockcroft and Gault equation (CLCRCG). Variability in meropenem serum concentrations was quantified at the middle and end of each monitored dosing interval. The attainment of two pharmacokinetic/pharmacodynamic targets (100\% T->MIC, 50\% T->4xMIC) was evaluated for minimum inhibitory concentration (MIC) values of 2 mg/L and 8 mg/L and standard meropenem dosing (1000 mg, 30-minute infusion, every 8 h). Furthermore, we assessed the impact of CLCRCG on meropenem concentrations and target attainment and developed a tool for risk assessment of target non-attainment. Results: Large inter-and intra-patient variability in meropenem concentrations was observed in the critically ill population (n = 48). Attainment of the target 100\% T->MIC was merely 48.4\% and 20.6\%, given MIC values of 2 mg/L and 8 mg/L, respectively, and similar for the target 50\% T->4xMIC. A hyperbolic relationship between CLCRCG (25-255 ml/minute) and meropenem serum concentrations at the end of the dosing interval (C-8h) was derived. For infections with pathogens of MIC 2 mg/L, mild renal impairment up to augmented renal function was identified as a risk factor for target non-attainment (for MIC 8 mg/L, additionally, moderate renal impairment). Conclusions: The investigated standard meropenem dosing regimen appeared to result in insufficient meropenem exposure in a considerable fraction of critically ill patients. An easy-and free-to-use tool (the MeroRisk Calculator) for assessing the risk of target non-attainment for a given renal function and MIC value was developed.},
  language  = {en}
}