@article{WichaHuisingaKloft2017, author = {Wicha, Sebastian G. and Huisinga, Wilhelm and Kloft, Charlotte}, title = {Translational pharmacometric evaluation of typical antibiotic broad-spectrum combination therapies against staphylococcus aureus exploiting in vitro information}, series = {CPT: pharmacometrics \& systems pharmacology}, volume = {6}, journal = {CPT: pharmacometrics \& systems pharmacology}, publisher = {Wiley}, address = {Hoboken}, issn = {2163-8306}, doi = {10.1002/psp4.12197}, pages = {512 -- 522}, year = {2017}, abstract = {Broad-spectrum antibiotic combination therapy is frequently applied due to increasing resistance development of infective pathogens. The objective of the present study was to evaluate two common empiric broad-spectrum combination therapies consisting of either linezolid (LZD) or vancomycin (VAN) combined with meropenem (MER) against Staphylococcus aureus (S. aureus) as the most frequent causative pathogen of severe infections. A semimechanistic pharmacokinetic-pharmacodynamic (PK-PD) model mimicking a simplified bacterial life-cycle of S. aureus was developed upon time-kill curve data to describe the effects of LZD, VAN, and MER alone and in dual combinations. The PK-PD model was successfully (i) evaluated with external data from two clinical S. aureus isolates and further drug combinations and (ii) challenged to predict common clinical PK-PD indices and breakpoints. Finally, clinical trial simulations were performed that revealed that the combination of VAN-MER might be favorable over LZD-MER due to an unfavorable antagonistic interaction between LZD and MER.}, language = {en} } @misc{OPUS4-53752, title = {Transnational American Jewish Studies}, series = {PaRDeS : Journal of the Association for Jewish Studies in Germany}, journal = {PaRDeS : Journal of the Association for Jewish Studies in Germany}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-520-0}, issn = {1614-6492}, doi = {10.25932/publishup-53752}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-537525}, pages = {143 -- 147}, year = {2021}, language = {en} } @article{BethgeSerthStaubitzetal.2021, author = {Bethge, Joseph and Serth, Sebastian and Staubitz, Thomas and Wuttke, Tobias and Nordemann, Oliver and Das, Partha-Pratim and Meinel, Christoph}, title = {TransPipe}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-51694}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-516943}, pages = {79 -- 94}, year = {2021}, abstract = {Online learning environments, such as Massive Open Online Courses (MOOCs), often rely on videos as a major component to convey knowledge. However, these videos exclude potential participants who do not understand the lecturer's language, regardless of whether that is due to language unfamiliarity or aural handicaps. Subtitles and/or interactive transcripts solve this issue, ease navigation based on the content, and enable indexing and retrieval by search engines. Although there are several automated speech-to-text converters and translation tools, their quality varies and the process of integrating them can be quite tedious. Thus, in practice, many videos on MOOC platforms only receive subtitles after the course is already finished (if at all) due to a lack of resources. This work describes an approach to tackle this issue by providing a dedicated tool, which is closing this gap between MOOC platforms and transcription and translation tools and offering a simple workflow that can easily be handled by users with a less technical background. The proposed method is designed and evaluated by qualitative interviews with three major MOOC providers.}, language = {en} } @article{Ette2015, author = {Ette, Ottmar}, title = {Tras la huella de la vida}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XVI}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {31}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, doi = {10.18443/219}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-88913}, pages = {21 -- 25}, year = {2015}, abstract = {El proyecto de larga duraci{\´o}n "Centro Alejandro de Humboldt - Ciencia en movimiento" (iniciado en 2015) de la Academia de las Ciencias y Humanidades Berl{\´i}n-Brandemburgo tiene como objetivo la edici{\´o}n de los manuscritos de viaje del famoso autor, naturalista, cosmop{\´o}lito y viajero. La edici{\´o}n incluir{\´a} los manuscritos de sus dos viajes hemisf{\´e}ricos (Am{\´e}rica, Asia) como tambi{\´e}n los de su legado literario. La pregunta esencial que acompa{\~n}a las investigaciones en torno al proyecto de la Academia es la importancia que Humboldt le da a la vida y a la convivencia. Los tres pilares en los que descansa la reflexi{\´o}n son: la relacionalidad, la concomitancia entre ciencia y est{\´e}tica y el movimiento.}, language = {es} } @article{Burek2023, author = {Burek, Wojciech}, title = {Treaty flexibility unilaterally boosted}, series = {Netherlands quarterly of human rights}, volume = {41}, journal = {Netherlands quarterly of human rights}, number = {1}, publisher = {Sage Publications Ltd}, address = {London}, issn = {0924-0519}, doi = {10.1177/09240519231151950}, pages = {35 -- 52}, year = {2023}, abstract = {Thus far, research into reservations to treaties has often overlooked reservations formulated to both European Social Charters (and its Protocols) and the relevant European Committee of Social Rights practices. There are several pressing reasons to further explore this gap in existing literature. First, an analysis of practices within the European Social Charters (and Protocols) will provide a fuller picture of the reservations and responses of treaty bodies. Second, in the context of previous landmark events it is worth noting the practices of another human rights treaty monitoring body that is often omitted from analyses. Third, the very fact that the formulation of reservations to treaties gives parties such far-reaching flexibility to shape their contractual obligations ({\`a} la carte) is surprising. An important outcome of the research is the finding that, despite the far-reaching flexibility present in the treaties analysed, both the States Parties and the European Committee of Social Rights generally treat them as conventional treaties to which the general rules on reservations apply. Consequently, there is no basis for assuming that the mere fact of adopting the {\`a} la carte system in a treaty with no reservation clause implies a formal prohibition of reservations or otherwise discourages their formulation.}, language = {en} } @article{DeusdaraLealSamprognaMohorCuartasetal.2022, author = {Deusdar{\´a}-Leal, Karinne and Samprogna Mohor, Guilherme and Cuartas, Luz Adriana and Seluchi, Marcelo E. and Marengo, Jose A. and Zhang, Rong and Broedel, Elisangela and Amore, Diogo de Jesus and Alval{\´a}, Regina C. S. and Cunha, Ana Paula M. A. and Gon{\c{c}}alves, Jos{\´e} A. C.}, title = {Trends and climate elasticity of streamflow in south-eastern Brazil basins}, series = {Water}, volume = {14}, journal = {Water}, number = {14}, publisher = {MDPI}, address = {Basel}, issn = {2073-4441}, doi = {10.3390/w14142245}, pages = {25}, year = {2022}, abstract = {Trends in streamflow, rainfall and potential evapotranspiration (PET) time series, from 1970 to 2017, were assessed for five important hydrological basins in Southeastern Brazil. The concept of elasticity was also used to assess the streamflow sensitivity to changes in climate variables, for annual data and 5-, 10- and 20-year moving averages. Significant negative trends in streamflow and rainfall and significant increasing trend in PET were detected. For annual analysis, elasticity revealed that 1\% decrease in rainfall resulted in 1.21-2.19\% decrease in streamflow, while 1\% increase in PET induced different reductions percentages in streamflow, ranging from 2.45\% to 9.67\%. When both PET and rainfall were computed to calculate the elasticity, results were positive for some basins. Elasticity analysis considering 20-year moving averages revealed that impacts on the streamflow were cumulative: 1\% decrease in rainfall resulted in 1.83-4.75\% decrease in streamflow, while 1\% increase in PET induced 3.47-28.3\% decrease in streamflow. This different temporal response may be associated with the hydrological memory of the basins. Streamflow appears to be more sensitive in less rainy basins. This study provides useful information to support strategic government decisions, especially when the security of water resources and drought mitigation are considered in face of climate change.}, language = {en} } @article{VehLuetzowKharlamovaetal.2022, author = {Veh, Georg and L{\"u}tzow, Natalie and Kharlamova, Varvara and Petrakov, Dmitry and Hugonnet, Romain and Korup, Oliver}, title = {Trends, Breaks, and Biases in the Frequency of Reported Glacier Lake Outburst Floods}, series = {Earth's Future}, volume = {10}, journal = {Earth's Future}, edition = {3}, publisher = {Wiley-Blackwell}, address = {Hoboken, New Jersey}, issn = {2328-4277}, doi = {10.1029/2021EF002426}, pages = {1 -- 14}, year = {2022}, abstract = {Thousands of glacier lakes have been forming behind natural dams in high mountains following glacier retreat since the early 20th century. Some of these lakes abruptly released pulses of water and sediment with disastrous downstream consequences. Yet it remains unclear whether the reported rise of these glacier lake outburst floods (GLOFs) has been fueled by a warming atmosphere and enhanced meltwater production, or simply a growing research effort. Here we estimate trends and biases in GLOF reporting based on the largest global catalog of 1,997 dated glacier-related floods in six major mountain ranges from 1901 to 2017. We find that the positive trend in the number of reported GLOFs has decayed distinctly after a break in the 1970s, coinciding with independently detected trend changes in annual air temperatures and in the annual number of field-based glacier surveys (a proxy of scientific reporting). We observe that GLOF reports and glacier surveys decelerated, while temperature rise accelerated in the past five decades. Enhanced warming alone can thus hardly explain the annual number of reported GLOFs, suggesting that temperature-driven glacier lake formation, growth, and failure are weakly coupled, or that outbursts have been overlooked. Indeed, our analysis emphasizes a distinct geographic and temporal bias in GLOF reporting, and we project that between two to four out of five GLOFs on average might have gone unnoticed in the early to mid-20th century. We recommend that such biases should be considered, or better corrected for, when attributing the frequency of reported GLOFs to atmospheric warming.}, language = {en} } @book{BarkowskyGiese2023, author = {Barkowsky, Matthias and Giese, Holger}, title = {Triple graph grammars for multi-version models}, number = {155}, isbn = {978-3-86956-556-9}, issn = {1613-5652}, doi = {10.25932/publishup-57399}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-573994}, publisher = {Universit{\"a}t Potsdam}, pages = {28 -- 28}, year = {2023}, abstract = {Like conventional software projects, projects in model-driven software engineering require adequate management of multiple versions of development artifacts, importantly allowing living with temporary inconsistencies. In the case of model-driven software engineering, employed versioning approaches also have to handle situations where different artifacts, that is, different models, are linked via automatic model transformations. In this report, we propose a technique for jointly handling the transformation of multiple versions of a source model into corresponding versions of a target model, which enables the use of a more compact representation that may afford improved execution time of both the transformation and further analysis operations. Our approach is based on the well-known formalism of triple graph grammars and a previously introduced encoding of model version histories called multi-version models. In addition to showing the correctness of our approach with respect to the standard semantics of triple graph grammars, we conduct an empirical evaluation that demonstrates the potential benefit regarding execution time performance.}, language = {en} } @article{KaechDennisVorburger2021, author = {Kaech, Heidi and Dennis, Alice B. and Vorburger, Christoph}, title = {Triple RNA-Seq characterizes aphid gene expression in response to infection with unequally virulent strains of the endosymbiont Hamiltonella defensa}, series = {BMC genomics}, volume = {22}, journal = {BMC genomics}, number = {1}, publisher = {BioMed Central}, address = {London}, issn = {1471-2164}, doi = {10.1186/s12864-021-07742-8}, pages = {21}, year = {2021}, abstract = {Background Secondary endosymbionts of aphids provide benefits to their hosts, but also impose costs such as reduced lifespan and reproductive output. The aphid Aphis fabae is host to different strains of the secondary endosymbiont Hamiltonella defensa, which encode different putative toxins. These strains have very different phenotypes: They reach different densities in the host, and the costs and benefits (protection against parasitoid wasps) they confer to the host vary strongly. Results We used RNA-Seq to generate hypotheses on why four of these strains inflict such different costs to A. fabae. We found different H. defensa strains to cause strain-specific changes in aphid gene expression, but little effect of H. defensa on gene expression of the primary endosymbiont, Buchnera aphidicola. The highly costly and over-replicating H. defensa strain H85 was associated with strongly reduced aphid expression of hemocytin, a marker of hemocytes in Drosophila. The closely related strain H15 was associated with downregulation of ubiquitin-related modifier 1, which is related to nutrient-sensing and oxidative stress in other organisms. Strain H402 was associated with strong differential regulation of a set of hypothetical proteins, the majority of which were only differentially regulated in presence of H402. Conclusions Overall, our results suggest that costs of different strains of H. defensa are likely caused by different mechanisms, and that these costs are imposed by interacting with the host rather than the host's obligatory endosymbiont B. aphidicola.}, language = {en} } @article{TrautmannZhouBrahmsetal.2021, author = {Trautmann, Justin and Zhou, Lin and Brahms, Clemens Markus and Tunca, Can and Ersoy, Cem and Granacher, Urs and Arnrich, Bert}, title = {TRIPOD}, series = {Data : open access ʻData in scienceʼ journal}, volume = {6}, journal = {Data : open access ʻData in scienceʼ journal}, number = {9}, publisher = {MDPI}, address = {Basel}, issn = {2306-5729}, doi = {10.3390/data6090095}, pages = {19}, year = {2021}, abstract = {Inertial measurement units (IMUs) enable easy to operate and low-cost data recording for gait analysis. When combined with treadmill walking, a large number of steps can be collected in a controlled environment without the need of a dedicated gait analysis laboratory. In order to evaluate existing and novel IMU-based gait analysis algorithms for treadmill walking, a reference dataset that includes IMU data as well as reliable ground truth measurements for multiple participants and walking speeds is needed. This article provides a reference dataset consisting of 15 healthy young adults who walked on a treadmill at three different speeds. Data were acquired using seven IMUs placed on the lower body, two different reference systems (Zebris FDMT-HQ and OptoGait), and two RGB cameras. Additionally, in order to validate an existing IMU-based gait analysis algorithm using the dataset, an adaptable modular data analysis pipeline was built. Our results show agreement between the pressure-sensitive Zebris and the photoelectric OptoGait system (r = 0.99), demonstrating the quality of our reference data. As a use case, the performance of an algorithm originally designed for overground walking was tested on treadmill data using the data pipeline. The accuracy of stride length and stride time estimations was comparable to that reported in other studies with overground data, indicating that the algorithm is equally applicable to treadmill data. The Python source code of the data pipeline is publicly available, and the dataset will be provided by the authors upon request, enabling future evaluations of IMU gait analysis algorithms without the need of recording new data.}, language = {en} } @article{HodgkinsRichardsonDommainetal.2018, author = {Hodgkins, Suzanne B. and Richardson, Curtis J. and Dommain, Rene and Wang, Hongjun and Glaser, Paul H. and Verbeke, Brittany and Winkler, B. Rose and Cobb, Alexander R. and Rich, Virginia I. and Missilmani, Malak and Flanagan, Neal and Ho, Mengchi and Hoyt, Alison M. and Harvey, Charles F. and Vining, S. Rose and Hough, Moira A. and Moore, Tim R. and Richard, Pierre J. H. and De la Cruz, Florentino B. and Toufaily, Joumana and Hamdan, Rasha and Cooper, William T. and Chanton, Jeffrey P.}, title = {Tropical peatland carbon storage linked to global latitudinal trends in peat recalcitrance}, series = {Nature Communications}, volume = {9}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-018-06050-2}, pages = {13}, year = {2018}, abstract = {Peatlands represent large terrestrial carbon banks. Given that most peat accumulates in boreal regions, where low temperatures and water saturation preserve organic matter, the existence of peat in (sub)tropical regions remains enigmatic. Here we examined peat and plant chemistry across a latitudinal transect from the Arctic to the tropics. Near-surface low-latitude peat has lower carbohydrate and greater aromatic content than near-surface high-latitude peat, creating a reduced oxidation state and resulting recalcitrance. This recalcitrance allows peat to persist in the (sub)tropics despite warm temperatures. Because we observed similar declines in carbohydrate content with depth in high-latitude peat, our data explain recent field-scale deep peat warming experiments in which catotelm (deeper) peat remained stable despite temperature increases up to 9 degrees C. We suggest that high-latitude deep peat reservoirs may be stabilized in the face of climate change by their ultimately lower carbohydrate and higher aromatic composition, similar to tropical peats.}, language = {en} } @article{Zagrebnov2020, author = {Zagrebnov, Valentin}, title = {Trotter product formula on Hilbert and Banach spaces for operator-norm convergence}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47197}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-471971}, pages = {23 -- 34}, year = {2020}, language = {en} } @article{Seng2020, author = {Seng, Helmut}, title = {Tr{\"a}ume statt Theurgie}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Transformative Translations in Jewish History and Culture}, volume = {2020}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Transformative Translations in Jewish History and Culture}, number = {11}, editor = {Amb{\"u}hl, Annemarie}, issn = {2364-7612}, doi = {10.34679/thersites.vol11.167}, pages = {247 -- 276}, year = {2020}, abstract = {In his work De insomniis (On Dreams), Synesios adopts a rather critical view of theurgy, resembling Porphyry's attitude; his wording shows polemical exaggeration. His insistence on the usefulness of dream revelation for hunting might be read as a (not too serious) claim to the divine inspiration of his work κυνηγετικαί.}, language = {de} } @article{Oehme2020, author = {Oehme, Annegret}, title = {Tu felix Camelot nube!}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Transformative Translations in Jewish History and Culture}, volume = {2020}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Transformative Translations in Jewish History and Culture}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-493-7}, issn = {1614-6492}, doi = {10.25932/publishup-48563}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-485637}, pages = {61 -- 74}, year = {2020}, abstract = {This article explores the ways in which the Yiddish Arthurian romance Viduvilt (sixteenth ct.) reworks its Middle High German model text, Wirnt von Grafenberg's Wigalois (1210/1220), for an early modern Jewish audience. Through seemingly minor changes, the adaptor creates a story world in which family politics play an essential role and become the driving force behind the story development. Part of this change is the reevaluation of female figures, in particular mothers. In contrast to its model, the Arthurian knight in Viduvilt is created as a figure that relies and depends largely on the decisions made by mothers, who are portrayed as powerful matres familias.}, language = {de} } @article{PetreskaPejovSandevetal.2022, author = {Petreska, Irina and Pejov, Ljupco and Sandev, Trifce and Kocarev, Ljupčo and Metzler, Ralf}, title = {Tuning of the dielectric relaxation and complex susceptibility in a system of polar molecules: a generalised model based on rotational diffusion with resetting}, series = {Fractal and fractional}, volume = {6}, journal = {Fractal and fractional}, number = {2}, publisher = {MDPI AG, Fractal Fract Editorial Office}, address = {Basel}, issn = {2504-3110}, doi = {10.3390/fractalfract6020088}, pages = {23}, year = {2022}, abstract = {The application of the fractional calculus in the mathematical modelling of relaxation processes in complex heterogeneous media has attracted a considerable amount of interest lately. The reason for this is the successful implementation of fractional stochastic and kinetic equations in the studies of non-Debye relaxation. In this work, we consider the rotational diffusion equation with a generalised memory kernel in the context of dielectric relaxation processes in a medium composed of polar molecules. We give an overview of existing models on non-exponential relaxation and introduce an exponential resetting dynamic in the corresponding process. The autocorrelation function and complex susceptibility are analysed in detail. We show that stochastic resetting leads to a saturation of the autocorrelation function to a constant value, in contrast to the case without resetting, for which it decays to zero. The behaviour of the autocorrelation function, as well as the complex susceptibility in the presence of resetting, confirms that the dielectric relaxation dynamics can be tuned by an appropriate choice of the resetting rate. The presented results are general and flexible, and they will be of interest for the theoretical description of non-trivial relaxation dynamics in heterogeneous systems composed of polar molecules.}, language = {en} } @article{BruckmaierKraussBinderetal.2021, author = {Bruckmaier, Georg and Krauss, Stefan and Binder, Karin and Hilbert, Sven Lars and Brunner, Martin}, title = {Tversky and Kahneman's cognitive illusions}, series = {Frontiers in psychology}, volume = {12}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2021.584689}, pages = {25}, year = {2021}, abstract = {In the present paper we empirically investigate the psychometric properties of some of the most famous statistical and logical cognitive illusions from the "heuristics and biases" research program by Daniel Kahneman and Amos Tversky, who nearly 50 years ago introduced fascinating brain teasers such as the famous Linda problem, the Wason card selection task, and so-called Bayesian reasoning problems (e.g., the mammography task). In the meantime, a great number of articles has been published that empirically examine single cognitive illusions, theoretically explaining people's faulty thinking, or proposing and experimentally implementing measures to foster insight and to make these problems accessible to the human mind. Yet these problems have thus far usually been empirically analyzed on an individual-item level only (e.g., by experimentally comparing participants' performance on various versions of one of these problems). In this paper, by contrast, we examine these illusions as a group and look at the ability to solve them as a psychological construct. Based on an sample of N = 2,643 Luxembourgian school students of age 16-18 we investigate the internal psychometric structure of these illusions (i.e., Are they substantially correlated? Do they form a reflexive or a formative construct?), their connection to related constructs (e.g., Are they distinguishable from intelligence or mathematical competence in a confirmatory factor analysis?), and the question of which of a person's abilities can predict the correct solution of these brain teasers (by means of a regression analysis).}, language = {en} } @misc{Jauer2021, author = {Jauer, Nora}, title = {Two milestones in favour of the environment in just a few days?}, publisher = {M. Riegner c/o Humboldt-Univ.}, address = {Berlin}, issn = {2510-2567}, doi = {10.17176/20211102-172527-0}, pages = {5}, year = {2021}, language = {en} } @book{PuergstallerNeuber2024, author = {P{\"u}rgstaller, Esther and Neuber, Nils}, title = {T{\"a}nzerischer Kreativit{\"a}tstest f{\"u}r 8- bis 12-J{\"a}hrige}, editor = {P{\"u}rgstaller, Esther and Neuber, Nils}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62704}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-627040}, publisher = {Universit{\"a}t Potsdam}, pages = {83}, year = {2024}, abstract = {Der t{\"a}nzerische Kreativit{\"a}tstest stellt ein valides Instrumentarium dar, welches auf tanzspezifischen Aufgaben basiert und f{\"u}r die differenzierte und standardisierte Erfassung der t{\"a}nzerischen Kreativit{\"a}t bei Kindern im Alter von 8 bis 12 Jahren konzipiert ist. Mit dem t{\"a}nzerischen Kreativit{\"a}tstest k{\"o}nnen nicht nur Fragestellungen zum Stand sowie zur Entwicklung t{\"a}nzerisch-kreativer F{\"a}higkeiten im Kindesalter bearbeitet werden, sondern er liefert auch wertvolle Informationen f{\"u}r die Optimierung von Trainings-, F{\"o}rder- und Vermittlungsmaßnahmen. Erfasst werden folgende t{\"a}nzerisch-kreativen F{\"a}higkeiten: 1) Vielfalt und Originalit{\"a}t in der Fortbewegung und in K{\"o}rperpositionen sowie 2) Ideenreichtum, Vielfalt und Originalit{\"a}t in der Gestaltung von Bewegungspatterns und -kompositionen. Dieser Test l{\"a}sst sich mit gr{\"o}ßeren Gruppen und minimalem materiellen Aufwand durchf{\"u}hren, ist zeitlich unbeschr{\"a}nkt und erm{\"o}glicht es, unterschiedliche Leistungsniveaus zu identifizieren. Der t{\"a}nzerische Kreativit{\"a}tstest bietet Forschenden und Lehrkr{\"a}ften eine wertvolle M{\"o}glichkeit, die t{\"a}nzerisch-kreativen F{\"a}higkeiten von Kindern zu analysieren und zu f{\"o}rdern.}, language = {de} } @article{DemarisWidigsonIlvemarketal.2022, author = {D{\´e}maris, Alix and Widigson, Ella S. K. and Ilvemark, Johan F. K. F. and Steenholdt, Casper and Seidelin, Jakob B. and Huisinga, Wilhelm and Michelet, Robin and Aulin, Linda B. S. and Kloft, Charlotte}, title = {Ulcerative colitis and acute severe ulcerative colitis patients are overlooked in infliximab population pharmacokinetic models}, series = {Pharmaceutics / Molecular Diversity Preservation International}, volume = {14}, journal = {Pharmaceutics / Molecular Diversity Preservation International}, number = {10}, publisher = {MDPI}, address = {Basel}, issn = {1999-4923}, doi = {10.3390/pharmaceutics14102095}, pages = {32}, year = {2022}, abstract = {Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour necrosis alpha monoclonal antibodies, including infliximab (IFX). Even though treatment of UC patients by IFX has been in place for over a decade, many gaps in modelling of IFX PK in this population remain. This is even more true for acute severe UC (ASUC) patients for which early prediction of IFX pharmacokinetic (PK) could highly improve treatment outcome. Thus, this review aims to compile and analyse published population PK models of IFX in UC and ASUC patients, and to assess the current knowledge on disease activity impact on IFX PK. For this, a semi-systematic literature search was conducted, from which 26 publications including a population PK model analysis of UC patients receiving IFX therapy were selected. Amongst those, only four developed a model specifically for UC patients, and only three populations included severe UC patients. Investigations of disease activity impact on PK were reported in only 4 of the 14 models selected. In addition, the lack of reported model codes and assessment of predictive performance make the use of published models in a clinical setting challenging. Thus, more comprehensive investigation of PK in UC and ASUC is needed as well as more adequate reports on developed models and their evaluation in order to apply them in a clinical setting.}, language = {en} } @techreport{WuttkeNeurothRothfritzetal.2021, author = {Wuttke, Ulrike and Neuroth, Heike and Rothfritz, Laura and Straka, Janine and Zeunert, Miriam and Schneemann, Carsten and Hartmann, Niklas and Radtke, Ina}, title = {Umfeldanalyse zum Aufbau einer neuen Datenkultur in Brandenburg}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-48090}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-480905}, pages = {112}, year = {2021}, abstract = {Digitale Forschungsdaten gewinnen zunehmend an Bedeutung und stellen neue Herausforderungen an wissenschaftliche Einrichtungen und ihre Forschenden. Der Begriff Forschungsdatenmanagement umfasst alle Aktivit{\"a}ten, die mit der Aufbereitung, Speicherung, Archivierung und Ver{\"o}ffentlichung von Forschungsdaten verbunden sind. Da der Umgang mit Forschungsdaten generische, fachliche, rechtliche und technische Aspekte betrifft, erfordert es eine Begleitung der Forschenden durch ein umfangreiches Spektrum an Services, von Information und Beratung bis hin zu fachspezifischen Standards und IT-Infrastrukturen. Im vorliegenden Bericht werden zun{\"a}chst die Ausgangslage und die Begrifflichkeiten rund um Forschungsdatenmanagement gekl{\"a}rt und anschließend die wichtigsten nationalen und internationalen Strategien und Entwicklungen vorgestellt. Dabei bilden Richtlinien und Empfehlungen f{\"u}r Forschungsdaten(management) den Handlungsrahmen f{\"u}r alle Beteiligte hin zu einem nachhaltigen Forschungsdatenmanagement. Bundeslandinitiativen schaffen die Grundlage und unterst{\"u}tzen den Kulturwandel zu offenen Daten. Eine Forschungsdaten-Strategie f{\"u}r Brandenburg muss die Bedeutung von digitalen Forschungsdaten als wissenschaftliches Gut in den Vordergrund stellen, indem daf{\"u}r das Bewusstsein geschaffen wird und konkrete Vorgaben und Leitlinien auf Landes- und Einrichtungsebene vereinbart werden. Gute wissenschaftliche Praxis wird durch eine geeignete Infrastruktur unterst{\"u}tzt, welche die heterogenen Bedarfe und Voraussetzungen aller Beteiligten ber{\"u}cksichtigt. Ziele sollten die Institutionalisierung von Forschungsdatenmanagement an den Hochschulen und Kooperationen zwischen den Einrichtungen Brandenburgs sein.}, language = {de} } @phdthesis{Ritt2022, author = {Ritt, Vanessa}, title = {Unbemannte Schiffe im Internationalen Seerecht}, series = {Acta Iuridica Universitatis Potsdamiensis}, journal = {Acta Iuridica Universitatis Potsdamiensis}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-522-4}, issn = {2199-9686}, doi = {10.25932/publishup-51938}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-519385}, school = {Universit{\"a}t Potsdam}, pages = {292}, year = {2022}, abstract = {Die internationale Schifffahrt erhofft sich mit der Entwicklung unbemannter Schiffe, die nur noch von Kontrollzentren an Land durch Personal {\"u}berwacht werden und sonst durch Elektromotoren und Solarenergie betrieben und mit selbstlernenden Navigationsprogrammen ausgestattet weitgehend autark agieren, eine Einsparung von Transportkosten von {\"u}ber 20 \%. Diese voranschreitende technische Entwicklung wird insbesondere das internationale Seerecht in Zukunft vor Herausforderungen stellen. Das Werk untersucht vor diesem Hintergrund prim{\"a}r die Kompatibilit{\"a}t dieser Schiffe mit dem Seerechts{\"u}bereinkommen. Zun{\"a}chst wird eine Schiffsdefinition f{\"u}r den Vertrag entwickelt und eine Anwendung des Regelwerks auf autonome Schiffe {\"u}berpr{\"u}ft. Dann wird auf Problemfelder wie die Einhaltung von Pflichten durch die Schiffe, die Notwendigkeit besonderer Schutzrechte vor allem in Bezug auf Zwangsmaßnahmen durch die K{\"u}stenstaaten an Bord und die Anwendbarkeit der bestehenden Piraterievorschriften auf diese Schiffe eingegangen. Weiter wirft die Arbeit die Frage auf, ob die Staatengemeinschaft, besonders mit Hinblick auf den maritimen Umweltschutz, nach dem Seerechts{\"u}bereinkommen eine Pflicht zur F{\"o}rderung unbemannter Schiffe hat. Abschließend wird auf erforderliche Cyber Security Maßnahmen f{\"u}r diesen besonderen Schiffstyp eingegangen. Insgesamt zeigt sich nach dieser Analyse, dass das Seerechts{\"u}bereinkommen, mit {\"u}berschaubaren Anpassungen, gut Anwendung auf autonome Schiffe finden kann.}, language = {de} } @article{KamaliLoriteWebberetal.2022, author = {Kamali, Bahareh and Lorite, Ignacio J. and Webber, Heidi A. and Rezaei, Ehsan Eyshi and Gabaldon-Leal, Clara and Nendel, Claas and Siebert, Stefan and Ramirez-Cuesta, Juan Miguel and Ewert, Frank and Ojeda, Jonathan J.}, title = {Uncertainty in climate change impact studies for irrigated maize cropping systems in southern Spain}, series = {Scientific reports}, volume = {12}, journal = {Scientific reports}, number = {1}, publisher = {Macmillan Publishers Limited,}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-022-08056-9}, pages = {13}, year = {2022}, abstract = {This study investigates the main drivers of uncertainties in simulated irrigated maize yield under historical conditions as well as scenarios of increased temperatures and altered irrigation water availability. Using APSIM, MONICA, and SIMPLACE crop models, we quantified the relative contributions of three irrigation water allocation strategies, three sowing dates, and three maize cultivars to the uncertainty in simulated yields. The water allocation strategies were derived from historical records of farmer's allocation patterns in drip-irrigation scheme of the Genil-Cabra region, Spain (2014-2017). By considering combinations of allocation strategies, the adjusted R-2 values (showing the degree of agreement between simulated and observed yields) increased by 29\% compared to unrealistic assumptions of considering only near optimal or deficit irrigation scheduling. The factor decomposition analysis based on historic climate showed that irrigation strategies was the main driver of uncertainty in simulated yields (66\%). However, under temperature increase scenarios, the contribution of crop model and cultivar choice to uncertainty in simulated yields were as important as irrigation strategy. This was partially due to different model structure in processes related to the temperature responses. Our study calls for including information on irrigation strategies conducted by farmers to reduce the uncertainty in simulated yields at field scale.}, language = {en} } @article{DevittNealWageneretal.2021, author = {Devitt, Laura and Neal, Jeffrey and Wagener, Thorsten and Coxon, Gemma}, title = {Uncertainty in the extreme flood magnitude estimates of large-scale flood hazard models}, series = {Environmental research letters : ERL / Institute of Physics}, volume = {16}, journal = {Environmental research letters : ERL / Institute of Physics}, number = {6}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1748-9326}, doi = {10.1088/1748-9326/abfac4}, pages = {15}, year = {2021}, abstract = {The growing worldwide impact of flood events has motivated the development and application of global flood hazard models (GFHMs). These models have become useful tools for flood risk assessment and management, especially in regions where little local hazard information is available. One of the key uncertainties associated with GFHMs is the estimation of extreme flood magnitudes to generate flood hazard maps. In this study, the 1-in-100 year flood (Q100) magnitude was estimated using flow outputs from four global hydrological models (GHMs) and two global flood frequency analysis datasets for 1350 gauges across the conterminous US. The annual maximum flows of the observed and modelled timeseries of streamflow were bootstrapped to evaluate the sensitivity of the underlying data to extrapolation. Results show that there are clear spatial patterns of bias associated with each method. GHMs show a general tendency to overpredict Western US gauges and underpredict Eastern US gauges. The GloFAS and HYPE models underpredict Q100 by more than 25\% in 68\% and 52\% of gauges, respectively. The PCR-GLOBWB and CaMa-Flood models overestimate Q100 by more than 25\% at 60\% and 65\% of gauges in West and Central US, respectively. The global frequency analysis datasets have spatial variabilities that differ from the GHMs. We found that river basin area and topographic elevation explain some of the spatial variability in predictive performance found in this study. However, there is no single model or method that performs best everywhere, and therefore we recommend a weighted ensemble of predictions of extreme flood magnitudes should be used for large-scale flood hazard assessment.}, language = {en} } @article{StoneNicenboimVasishthetal.2023, author = {Stone, Kate and Nicenboim, Bruno and Vasishth, Shravan and R{\"o}sler, Frank}, title = {Understanding the effects of constraint and predictability in ERP}, series = {Neurobiology of language}, volume = {4}, journal = {Neurobiology of language}, number = {2}, publisher = {MIT Press}, address = {Cambridge, MA, USA}, issn = {2641-4368}, doi = {10.1162/nol_a_00094}, pages = {221 -- 256}, year = {2023}, abstract = {Intuitively, strongly constraining contexts should lead to stronger probabilistic representations of sentences in memory. Encountering unexpected words could therefore be expected to trigger costlier shifts in these representations than expected words. However, psycholinguistic measures commonly used to study probabilistic processing, such as the N400 event-related potential (ERP) component, are sensitive to word predictability but not to contextual constraint. Some research suggests that constraint-related processing cost may be measurable via an ERP positivity following the N400, known as the anterior post-N400 positivity (PNP). The PNP is argued to reflect update of a sentence representation and to be distinct from the posterior P600, which reflects conflict detection and reanalysis. However, constraint-related PNP findings are inconsistent. We sought to conceptually replicate Federmeier et al. (2007) and Kuperberg et al. (2020), who observed that the PNP, but not the N400 or the P600, was affected by constraint at unexpected but plausible words. Using a pre-registered design and statistical approach maximising power, we demonstrated a dissociated effect of predictability and constraint: strong evidence for predictability but not constraint in the N400 window, and strong evidence for constraint but not predictability in the later window. However, the constraint effect was consistent with a P600 and not a PNP, suggesting increased conflict between a strong representation and unexpected input rather than greater update of the representation. We conclude that either a simple strong/weak constraint design is not always sufficient to elicit the PNP, or that previous PNP constraint findings could be an artifact of smaller sample size.}, language = {en} } @article{TrouwloonStreckChagasetal.2023, author = {Trouwloon, Danick and Streck, Charlotte and Chagas, Thiago and Martinus, Glenpherd}, title = {Understanding the use of carbon credits by companies}, series = {Global challenges (Hoboken, NJ)}, volume = {7}, journal = {Global challenges (Hoboken, NJ)}, number = {4}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {2056-6646}, doi = {10.1002/gch2.202200158}, pages = {18}, year = {2023}, abstract = {Worldwide, companies are increasingly making claims about their current climate efforts and their future mitigation commitments. These claims tend to be underpinned by carbon credits issued in voluntary carbon markets to offset emissions. Corporate climate claims are largely unregulated which means that they are often (perceived to be) misleading and deceptive. As such, corporate climate claims risk undermining, rather than contributing to, global climate mitigation. This paper takes as its point of departure the proposition that a better understanding of corporate climate claims is needed to govern such claims in a manner that adequately addresses potential greenwashing risks. To that end, the paper reviews the nascent literature on corporate climate claims relying on the use of voluntary carbon credits. Drawing on the reviewed literature, three key dimensions of corporate climate claims as related to carbon credits are discussed: 1) the intended use of carbon credits: offsetting versus non-offsetting claims; 2) the framing and meaning of headline terms: net-zero versus carbon neutral claims; and 3) the status of the claim: future aspirational commitments versus stated achievements. The paper thereby offers a preliminary categorization of corporate climate claims and discusses risks associated with and governance implications for each of these categories.}, language = {en} } @article{FrielerSchaubergerArnethetal.2017, author = {Frieler, Katja and Schauberger, Bernhard and Arneth, Almut and Balkovic, Juraj and Chryssanthacopoulos, James and Deryng, Delphine and Elliott, Joshua and Folberth, Christian and Khabarov, Nikolay and M{\"u}ller, Christoph and Olin, Stefan and Pugh, Thomas A. M. and Schaphoff, Sibyll and Schewe, Jacob and Schmid, Erwin and Warszawski, Lila and Levermann, Anders}, title = {Understanding the weather signal in national crop-yield variability}, series = {Earths future}, volume = {5}, journal = {Earths future}, publisher = {Wiley}, address = {Hoboken}, issn = {2328-4277}, doi = {10.1002/2016EF000525}, pages = {605 -- 616}, year = {2017}, abstract = {Year-to-year variations in crop yields can have major impacts on the livelihoods of subsistence farmers and may trigger significant global price fluctuations, with severe consequences for people in developing countries. Fluctuations can be induced by weather conditions, management decisions, weeds, diseases, and pests. Although an explicit quantification and deeper understanding of weather-induced crop-yield variability is essential for adaptation strategies, so far it has only been addressed by empirical models. Here, we provide conservative estimates of the fraction of reported national yield variabilities that can be attributed to weather by state-of-the-art, process-based crop model simulations. We find that observed weather variations can explain more than 50\% of the variability in wheat yields in Australia, Canada, Spain, Hungary, and Romania. For maize, weather sensitivities exceed 50\% in seven countries, including the United States. The explained variance exceeds 50\% for rice in Japan and South Korea and for soy in Argentina. Avoiding water stress by simulating yields assuming full irrigation shows that water limitation is a major driver of the observed variations in most of these countries. Identifying the mechanisms leading to crop-yield fluctuations is not only fundamental for dampening fluctuations, but is also important in the context of the debate on the attribution of loss and damage to climate change. Since process-based crop models not only account for weather influences on crop yields, but also provide options to represent human-management measures, they could become essential tools for differentiating these drivers, and for exploring options to reduce future yield fluctuations.}, language = {en} } @article{WangSenoSokolovetal.2020, author = {Wang, Wei and Seno, Flavio and Sokolov, Igor M. and Chechkin, Aleksei V. and Metzler, Ralf}, title = {Unexpected crossovers in correlated random-diffusivity processes}, series = {New Journal of Physics}, volume = {22}, journal = {New Journal of Physics}, publisher = {Dt. Physikalische Ges.}, address = {Bad Honnef}, issn = {1367-2630}, doi = {10.1088/1367-2630/aba390}, pages = {17}, year = {2020}, abstract = {The passive and active motion of micron-sized tracer particles in crowded liquids and inside living biological cells is ubiquitously characterised by 'viscoelastic' anomalous diffusion, in which the increments of the motion feature long-ranged negative and positive correlations. While viscoelastic anomalous diffusion is typically modelled by a Gaussian process with correlated increments, so-called fractional Gaussian noise, an increasing number of systems are reported, in which viscoelastic anomalous diffusion is paired with non-Gaussian displacement distributions. Following recent advances in Brownian yet non-Gaussian diffusion we here introduce and discuss several possible versions of random-diffusivity models with long-ranged correlations. While all these models show a crossover from non-Gaussian to Gaussian distributions beyond some correlation time, their mean squared displacements exhibit strikingly different behaviours: depending on the model crossovers from anomalous to normal diffusion are observed, as well as a priori unexpected dependencies of the effective diffusion coefficient on the correlation exponent. Our observations of the non-universality of random-diffusivity viscoelastic anomalous diffusion are important for the analysis of experiments and a better understanding of the physical origins of 'viscoelastic yet non-Gaussian' diffusion.}, language = {en} } @article{QuarmbyKhajooeiKurtzetal.2023, author = {Quarmby, Andrew James and Khajooei, Mina and Kurtz, Philip and Henschke, Jakob and Kim, MyoungHwee and Mayer, Frank and Engel, Tilman}, title = {Unexpected running perturbations}, series = {Frontiers in sports and active living}, volume = {5}, journal = {Frontiers in sports and active living}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2023.1129058}, pages = {14}, year = {2023}, abstract = {Introduction Balance is vital for human health and experiments have been conducted to measure the mechanisms of postural control, for example studying reflex responses to simulated perturbations. Such studies are frequent in walking but less common in running, and an understanding of reflex responses to trip-like disturbances could enhance our understanding of human gait and improve approaches to training and rehabilitation. Therefore, the primary aim of this study was to investigate the technical validity and reliability of a treadmill running protocol with perturbations. A further exploratory aim was to evaluate the associated neuromuscular reflex responses to the perturbations, in the lower limbs. Methods Twelve healthy participants completed a running protocol (9 km/h) test-retest (2 weeks apart), whereby 30 unilateral perturbations were executed via the treadmill belts (presets:2.0 m/s amplitude;150 ms delay (post-heel contact);100ms duration). Validity of the perturbations was assessed via mean +/- SD comparison, percentage error calculation between the preset and recorded perturbation characteristics (PE\%), and coefficient of variation (CV\%). Test-retest reliability (TRV\%) and Bland-Altman analysis (BLA; bias +/- 1.96 * SD) was calculated for reliability. To measure reflex activity, electromyography (EMG) was applied in both legs. EMG amplitudes (root mean square normalized to unperturbed strides) and latencies [ms] were analysed descriptively. Results Left-side perturbation amplitude was 1.9 +/- 0.1 m/s, delay 105 +/- 2 ms, and duration 78 +/- 1 ms. Right-side perturbation amplitude was 1.9 +/- 0.1 m/s, delay 118 +/- 2 ms, duration 78 +/- 1 ms. PE\% ranged from 5-30\% for the recorded perturbations. CV\% of the perturbations ranged from 19.5-76.8\%. TRV\% for the perturbations was 6.4-16.6\%. BLA for the left was amplitude: 0.0 +/- 0.3m/s, delay: 0 +/- 17 ms, duration: 2 +/- 13 ms, and for the right was amplitude: 0.1 +/- 0.7, delay: 4 +/- 40 ms, duration: 1 +/- 35 ms. EMG amplitudes ranged from 175 +/- 141\%-454 +/- 359\% in both limbs. Latencies were 109 +/- 12-116 +/- 23 ms in the tibialis anterior, and 128 +/- 49-157 +/- 20 ms in the biceps femoris. Discussion Generally, this study indicated sufficient validity and reliability of the current setup considering the technical challenges and limitations, although the reliability of the right-sided perturbations could be questioned. The protocol provoked reflex responses in the lower extremities, especially in the leading leg. Acute neuromusculoskeletal adjustments to the perturbations could be studied and compared in clinical and healthy running populations, and the protocol could be utilised to monitor chronic adaptations to interventions over time.}, language = {en} } @article{PostClassKohler2020, author = {Post, Julia C. and Class, Fabian and Kohler, Ulrich}, title = {Unit nonresponse biases in estimates of SARS-CoV-2 prevalence}, series = {Survey research methods}, volume = {14}, journal = {Survey research methods}, number = {2}, publisher = {European Survey Research Association}, address = {Duisburg}, issn = {1864-3361}, doi = {10.18148/srm/2020.v14i2.7755}, pages = {115 -- 121}, year = {2020}, abstract = {Since COVID-19 became a pandemic, many studies are being conducted to get a better understanding of the disease itself and its spread. One crucial indicator is the prevalence of SARS-CoV-2 infections. Since this measure is an important foundation for political decisions, its estimate must be reliable and unbiased. This paper presents reasons for biases in prevalence estimates due to unit nonresponse in typical studies. Since it is difficult to avoid bias in situations with mostly unknown nonresponse mechanisms, we propose the maximum amount of bias as one measure to assess the uncertainty due to nonresponse. An interactive web application is presented that calculates the limits of such a conservative unit nonresponse confidence interval (CUNCI).}, language = {en} } @article{SeržantMoroz2022, author = {Seržant, Ilja A. and Moroz, George A.}, title = {Universal attractors in language evolution provide evidence for the kinds of efficiency pressures involved}, series = {Humanities \& Social Sciences Communications}, volume = {9}, journal = {Humanities \& Social Sciences Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-9992}, doi = {10.1057/s41599-022-01072-0}, pages = {9}, year = {2022}, abstract = {Efficiency is central to understanding the communicative and cognitive underpinnings of language. However, efficiency management is a complex mechanism in which different efficiency effects-such as articulatory, processing and planning ease, mental accessibility, and informativity, online and offline efficiency effects-conspire to yield the coding of linguistic signs. While we do not yet exactly understand the interactional mechanism of these different effects, we argue that universal attractors are an important component of any dynamic theory of efficiency that would be aimed at predicting efficiency effects across languages. Attractors are defined as universal states around which language evolution revolves. Methodologically, we approach efficiency from a cross-linguistic perspective on the basis of a world-wide sample of 383 languages from 53 families, balancing all six macro-areas (Eurasia, North and South America, Australia, Africa, and Oceania). We explore the grammatical domain of verbal person-number subject indexes. We claim that there is an attractor state in this domain to which languages tend to develop and tend not to leave if they happen to comply with the attractor in their earlier stages of evolution. The attractor is characterized by different lengths for each person and number combination, structured along Zipf's predictions. Moreover, the attractor strongly prefers non-compositional, cumulative coding of person and number. On the basis of these and other properties of the attractor, we conclude that there are two domains in which efficiency pressures are most powerful: strive towards less processing and articulatory effort. The latter, however, is overridden by constant information flow. Strive towards lower lexicon complexity and memory costs are weaker efficiency pressures for this grammatical category due to its order of frequency.}, language = {en} } @article{SposiniGrebenkovMetzleretal.2020, author = {Sposini, Vittoria and Grebenkov, Denis S. and Metzler, Ralf and Oshanin, Gleb and Seno, Flavio}, title = {Universal spectral features of different classes of random-diffusivity processes}, series = {New Journal of Physics}, volume = {22}, journal = {New Journal of Physics}, number = {6}, publisher = {Dt. Physikalische Ges.}, address = {Bad Honnef}, issn = {1367-2630}, doi = {10.1088/1367-2630/ab9200}, pages = {26}, year = {2020}, abstract = {Stochastic models based on random diffusivities, such as the diffusing-diffusivity approach, are popular concepts for the description of non-Gaussian diffusion in heterogeneous media. Studies of these models typically focus on the moments and the displacement probability density function. Here we develop the complementary power spectral description for a broad class of random-diffusivity processes. In our approach we cater for typical single particle tracking data in which a small number of trajectories with finite duration are garnered. Apart from the diffusing-diffusivity model we study a range of previously unconsidered random-diffusivity processes, for which we obtain exact forms of the probability density function. These new processes are different versions of jump processes as well as functionals of Brownian motion. The resulting behaviour subtly depends on the specific model details. Thus, the central part of the probability density function may be Gaussian or non-Gaussian, and the tails may assume Gaussian, exponential, log-normal, or even power-law forms. For all these models we derive analytically the moment-generating function for the single-trajectory power spectral density. We establish the generic 1/f²-scaling of the power spectral density as function of frequency in all cases. Moreover, we establish the probability density for the amplitudes of the random power spectral density of individual trajectories. The latter functions reflect the very specific properties of the different random-diffusivity models considered here. Our exact results are in excellent agreement with extensive numerical simulations.}, language = {en} } @article{RitschelCherstvyMetzler2021, author = {Ritschel, Stefan and Cherstvy, Andrey G. and Metzler, Ralf}, title = {Universality of delay-time averages for financial time series}, series = {Journal of physics. Complexity}, volume = {2}, journal = {Journal of physics. Complexity}, number = {4}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2632-072X}, doi = {10.1088/2632-072X/ac2220}, pages = {30}, year = {2021}, abstract = {We analyze historical data of stock-market prices for multiple financial indices using the concept of delay-time averaging for the financial time series (FTS). The region of validity of our recent theoretical predictions [Cherstvy A G et al 2017 New J. Phys. 19 063045] for the standard and delayed time-averaged mean-squared 'displacements' (TAMSDs) of the historical FTS is extended to all lag times. As the first novel element, we perform extensive computer simulations of the stochastic differential equation describing geometric Brownian motion (GBM) which demonstrate a quantitative agreement with the analytical long-term price-evolution predictions in terms of the delayed TAMSD (for all stock-market indices in crisis-free times). Secondly, we present a robust procedure of determination of the model parameters of GBM via fitting the features of the price-evolution dynamics in the FTS for stocks and cryptocurrencies. The employed concept of single-trajectory-based time averaging can serve as a predictive tool (proxy) for a mathematically based assessment and rationalization of probabilistic trends in the evolution of stock-market prices.}, language = {en} } @article{DespujolTurroBusquets2021, author = {Despujol, Ignacio and Turr{\´o}, Carlos and Busquets, Jaime}, title = {Universitat Polit{\`e}cnica de Val{\`e}ncia's Experience with EDX MOOC Initiatives During the Covid Lockdown}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51719}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517196}, pages = {181 -- 185}, year = {2021}, abstract = {In March 2020, when massive lockdowns started to be enforced around the world to contain the spread of the COVID-19 pandemic, edX launched two initiatives to help students around the world providing free certificates for its courses, RAP, for member institutions and OCE, for any accredited academic institution. In this paper we analyze how Universitat Polt{\`e}cnica de Val{\`e}ncia contributed with its courses to both initiatives, providing almost 14,000 free certificate codes in total, and how UPV used the RAP initiative as a customer, describing the mechanism used to distribute more than 22,000 codes for free certificates to more than 7,000 UPV community members, what led to the achievement of more than 5,000 free certificates. We also comment the results of a post initiative survey answered by 1,612 UPV members about 3,241 edX courses, in which they communicated a satisfaction of 4,69 over 5 with the initiative.}, language = {en} } @article{WiebelerVollbrechtNeubaetal.2021, author = {Wiebeler, Christian and Vollbrecht, Joachim and Neuba, Adam and Kitzerow, Heinz and Schumacher, Stefan}, title = {Unraveling the electrochemical and spectroscopic properties of neutral and negatively charged perylene tetraethylesters}, series = {Scientific reports}, volume = {11}, journal = {Scientific reports}, number = {1}, publisher = {Macmillan Publishers Limited, part of Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-021-95551-0}, pages = {11}, year = {2021}, abstract = {A detailed investigation of the energy levels of perylene-3,4,9,10-tetracarboxylic tetraethylester as a representative compound for the whole family of perylene esters was performed. It was revealed via electrochemical measurements that one oxidation and two reductions take place. The bandgaps determined via the electrochemical approach are in good agreement with the optical bandgap obtained from the absorption spectra via a Tauc plot. In addition, absorption spectra in dependence of the electrochemical potential were the basis for extensive quantum-chemical calculations of the neutral, monoanionic, and dianionic molecules. For this purpose, calculations based on density functional theory were compared with post-Hartree-Fock methods and the CAM-B3LYP functional proved to be the most reliable choice for the calculation of absorption spectra. Furthermore, spectral features found experimentally could be reproduced with vibronic calculations and allowed to understand their origins. In particular, the two lowest energy absorption bands of the anion are not caused by absorption of two distinct electronic states, which might have been expected from vertical excitation calculations, but both states exhibit a strong vibronic progression resulting in contributions to both bands.}, language = {en} } @article{VilkAghionAvgaretal.2022, author = {Vilk, Ohad and Aghion, Erez and Avgar, Tal and Beta, Carsten and Nagel, Oliver and Sabri, Adal and Sarfati, Raphael and Schwartz, Daniel K. and Weiß, Matthias and Krapf, Diego and Nathan, Ran and Metzler, Ralf and Assaf, Michael}, title = {Unravelling the origins of anomalous diffusion}, series = {Physical review research / American Physical Society}, volume = {4}, journal = {Physical review research / American Physical Society}, number = {3}, publisher = {American Physical Society}, address = {College Park, MD}, issn = {2643-1564}, doi = {10.1103/PhysRevResearch.4.033055}, pages = {16}, year = {2022}, abstract = {Anomalous diffusion or, more generally, anomalous transport, with nonlinear dependence of the mean-squared displacement on the measurement time, is ubiquitous in nature. It has been observed in processes ranging from microscopic movement of molecules to macroscopic, large-scale paths of migrating birds. Using data from multiple empirical systems, spanning 12 orders of magnitude in length and 8 orders of magnitude in time, we employ a method to detect the individual underlying origins of anomalous diffusion and transport in the data. This method decomposes anomalous transport into three primary effects: long-range correlations ("Joseph effect"), fat-tailed probability density of increments ("Noah effect"), and nonstationarity ("Moses effect"). We show that such a decomposition of real-life data allows us to infer nontrivial behavioral predictions and to resolve open questions in the fields of single-particle tracking in living cells and movement ecology.}, language = {en} } @article{WestphalVockKretschmann2021, author = {Westphal, Andrea and Vock, Miriam and Kretschmann, Julia}, title = {Unravelling the relationship between teacher-assigned grades, student personality, and standardized test scores}, series = {Frontiers in psychology / Frontiers Research Foundation}, journal = {Frontiers in psychology / Frontiers Research Foundation}, number = {12}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2021.627440}, pages = {11}, year = {2021}, abstract = {The Big Five personality traits play a major role in student achievement. As such, there is consistent evidence that students that are more conscientious receive better teacher-assigned grades in secondary school. However, research often does not support the claim that students that are more conscientious similarly achieve higher scores in domain-specific standardized achievement tests. Based on the Invest-and-Accrue Model, we argue that conscientiousness explains to some extent why certain students receive better grades despite similar academic accomplishments (i.e., achieving similar scores in domain-specific standardized achievement tests). Therefore, the present study examines to what extent the relationship between student personality and teacher-assigned grades consists of direct as opposed to indirect associations (via subject-specific standardized test scores). We used a representative sample of 14,710 ninth-grade students to estimate these direct and indirect pathways in mathematics and German. Structural equation models showed that test scores explained between 8 and 11\% of the variance in teacher-assigned grades in mathematics and German. The Big Five personality traits in students additionally explained between 8 and 10\% of the variance in grades. Finally, the personality-grade relationship consisted of direct (0.02 | β| ≤ 0.27) and indirect associations via test scores (0.01 | β| ≤ 0.07). Conscientiousness explained discrepancies between teacher-assigned grades and students' scores in domain-specific standardized tests to a greater extent than any of the other Big Five personality traits. Our findings suggest that students that are more conscientious may invest more effort to accomplish classroom goals, but fall short of mastery.}, language = {en} } @article{KurthsAgarwalShuklaetal.2019, author = {Kurths, J{\"u}rgen and Agarwal, Ankit and Shukla, Roopam and Marwan, Norbert and Maheswaran, Rathinasamy and Caesar, Levke and Krishnan, Raghavan and Merz, Bruno}, title = {Unravelling the spatial diversity of Indian precipitation teleconnections via a non-linear multi-scale approach}, series = {Nonlinear processes in geophysics}, volume = {26}, journal = {Nonlinear processes in geophysics}, number = {3}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1023-5809}, doi = {10.5194/npg-26-251-2019}, pages = {251 -- 266}, year = {2019}, abstract = {A better understanding of precipitation dynamics in the Indian subcontinent is required since India's society depends heavily on reliable monsoon forecasts. We introduce a non-linear, multiscale approach, based on wavelets and event synchronization, for unravelling teleconnection influences on precipitation. We consider those climate patterns with the highest relevance for Indian precipitation. Our results suggest significant influences which are not well captured by only the wavelet coherence analysis, the state-of-the-art method in understanding linkages at multiple timescales. We find substantial variation across India and across timescales. In particular, El Ni{\~n}o-Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD) mainly influence precipitation in the south-east at interannual and decadal scales, respectively, whereas the North Atlantic Oscillation (NAO) has a strong connection to precipitation, particularly in the northern regions. The effect of the Pacific Decadal Oscillation (PDO) stretches across the whole country, whereas the Atlantic Multidecadal Oscillation (AMO) influences precipitation particularly in the central arid and semi-arid regions. The proposed method provides a powerful approach for capturing the dynamics of precipitation and, hence, helps improve precipitation forecasting.}, language = {en} } @misc{Bilgen2024, author = {Bilgen, Isa}, title = {Unsere W{\"u}rde in Euren H{\"a}nden}, series = {Verfassungsblog : on matters constitutional}, journal = {Verfassungsblog : on matters constitutional}, publisher = {Max Steinbeis Verfassungsblog gGmbH}, address = {Berlin}, issn = {2366-7044}, doi = {10.17176/20240204-004217-0}, pages = {9}, year = {2024}, language = {de} } @article{GoodwinMuddClubb2018, author = {Goodwin, Guillaume C. H. and Mudd, Simon M. and Clubb, Fiona J.}, title = {Unsupervised detection of salt marsh platforms}, series = {Earth surface dynamics}, volume = {6}, journal = {Earth surface dynamics}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2196-6311}, doi = {10.5194/esurf-6-239-2018}, pages = {239 -- 255}, year = {2018}, abstract = {Salt marshes filter pollutants, protect coastlines against storm surges, and sequester carbon, yet are under threat from sea level rise and anthropogenic modification. The sustained existence of the salt marsh ecosystem depends on the topographic evolution of marsh platforms. Quantifying marsh platform topography is vital for improving the management of these valuable landscapes. The determination of platform boundaries currently relies on supervised classification methods requiring near-infrared data to detect vegetation, or demands labour-intensive field surveys and digitisation. We propose a novel, unsupervised method to reproducibly isolate salt marsh scarps and platforms from a digital elevation model (DEM), referred to as Topographic Identification of Platforms (TIP). Field observations and numerical models show that salt marshes mature into subhorizontal platforms delineated by subvertical scarps. Based on this premise, we identify scarps as lines of local maxima on a slope raster, then fill landmasses from the scarps upward, thus isolating mature marsh platforms. We test the TIP method using lidar-derived DEMs from six salt marshes in England with varying tidal ranges and geometries, for which topographic platforms were manually isolated from tidal flats. Agreement between manual and unsupervised classification exceeds 94\% for DEM resolutions of 1 m, with all but one site maintaining an accuracy superior to 90\% for resolutions up to 3 m. For resolutions of 1 m, platforms detected with the TIP method are comparable in surface area to digitised platforms and have similar elevation distributions. We also find that our method allows for the accurate detection of local block failures as small as 3 times the DEM resolution. Detailed inspection reveals that although tidal creeks were digitised as part of the marsh platform, unsupervised classification categorises them as part of the tidal flat, causing an increase in false negatives and overall platform perimeter. This suggests our method may benefit from combination with existing creek detection algorithms. Fallen blocks and high tidal flat portions, associated with potential pioneer zones, can also lead to differences between our method and supervised mapping. Although pioneer zones prove difficult to classify using a topographic method, we suggest that these transition areas should be considered when analysing erosion and accretion processes, particularly in the case of incipient marsh platforms. Ultimately, we have shown that unsupervised classification of marsh platforms from high-resolution topography is possible and sufficient to monitor and analyse topographic evolution.}, language = {en} } @article{MientusNowakWulffetal.2023, author = {Mientus, Lukas and Nowak, Anna and Wulff, Peter and Borowski, Andreas}, title = {Unterrichtsanalyse und Reflexion}, series = {Reflexion in der Lehrkr{\"a}ftebildung: Empirisch - Phasen{\"u}bergreifend - Interdisziplin{\"a}r (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 4)}, journal = {Reflexion in der Lehrkr{\"a}ftebildung: Empirisch - Phasen{\"u}bergreifend - Interdisziplin{\"a}r (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 4)}, number = {4}, editor = {Mientus, Lukas and Klempin, Christiane and Nowak, Anna}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-566-8}, issn = {2626-3556}, doi = {10.25932/publishup-63200}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-632005}, pages = {445 -- 452}, year = {2023}, abstract = {Schulpraktische Phasen stellen eine bedeutende praxisnahe Lerngelegenheit im Lehramtsstudium dar, da sie Raum f{\"u}r umfangreiche Reflexionen der eigenen Lernerfahrung bieten. Das im Studium erworbene theoretisch-formale Wissen steht hierbei dem praktischen Wissen und K{\"o}nnen gegen{\"u}ber. Mit der professionellen Entwicklung im Referendariat, besonders im Kompetenzbereich des Unterrichtens, kann geschlussfolgert werden, dass sich eine Reflexion {\"u}ber eher fachliche Aspekte unter den Studierenden im Referendariat auf eine Reflexion {\"u}ber eher {\"u}berfachliche und p{\"a}dagogische Aspekte weitet. Infolge der Analyse von N = 55 schriftlichen Fremdreflexionen von angehenden Physiklehrkr{\"a}ften aus Studium und Referendariat konnte diese Hypothese f{\"u}r den Bereich der Unterrichtsanalyse und -reflexion unterst{\"u}tzt werden. Weiter wurde aus der Videovignette ein Workshopangebot f{\"u}r Lehrkr{\"a}fte der zweiten und dritten Phase der Lehrkr{\"a}ftebildung entwickelt, erprobt und evaluiert.}, language = {de} } @techreport{DillenardtThieken2021, author = {Dillenardt, Lisa and Thieken, Annegret}, title = {Untersuchung der r{\"a}umlichen Verteilung von Bodenk{\"u}hlpotenzialen in Remscheid}, doi = {10.25932/publishup-52667}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-526670}, pages = {III, 40}, year = {2021}, abstract = {Eine Zunahme der allgemeinen Temperatur auf Grund des Klimawandels und die damit einhergehende Zunahme von Hitzewellen f{\"u}hrten dazu, dass das Landesamt f{\"u}r Umwelt und Verbraucherschutz Nordrhein-Westfalen (LANUV) einen Leitfaden f{\"u}r den Schutz der positiven Klimafunktion urbaner B{\"o}den herausgab. Darauf aufbauend wurde auf regionaler Ebene f{\"u}r die Stadt D{\"u}sseldorf die K{\"u}hlleistung der urbanen B{\"o}den quantifiziert, um besonders schutzw{\"u}rdige Bereiche zu identifizieren. Im Rahmen des Projektes ExTrass sollte nun die K{\"u}hlleistung urbaner B{\"o}den innerhalb Remscheids quantifiziert werden, jedoch auf Basis von frei zug{\"a}nglichen Daten. Eine solche Datengrundlage schließt eine Modellierung des Bodenwasserhaushaltes, welches die Grundlage der Quantifizierung in D{\"u}sseldorf war, f{\"u}r Remscheid aus. Jedoch bietet der vorgestellte Ansatz die M{\"o}glichkeit, eine solche Untersuchung auch in anderen Gemeinden innerhalb Deutschlands mit relativ wenig Aufwand durchzuf{\"u}hren. Die K{\"u}hlleistung der B{\"o}den wurde {\"u}ber die nutzbare Feldkapazit{\"a}t abgesch{\"a}tzt, welche das Wasserspeichervolumen der obersten durchwurzelten Bodenzone angibt. Es ist der Bodenwasserspeicher, der Wasser f{\"u}r die Evapotranspiration zur Verf{\"u}gung stellt und damit maßgeblich die K{\"u}hlleistung eines Bodens definiert, d.h. durch direkte Evaporation des Bodenwassers sowie durch die Transpiration von Wasser durch Pflanzen. In die Erstellung der Karte sind eingegangen: (a) die Bodenkarte Nordrhein-Westfalens (BK50), um die nutzbare Feldkapazit{\"a}t (nFK) je Fl{\"a}che zu bestimmen; (b) der Landnutzungsdatensatz UrbanAtlas 2012, in Verbindung mit einer Literaturrecherche, um den Einfluss der Landnutzung auf die Werte der nFK, insbesondere im Hinblick auf Versiegelung und Verdichtung herzuleiten; und (c) OpenStreetMap (OSM), um den Anteil der versiegelten Fl{\"a}chen genauer zu bestimmen, als dies auf Basis des UrbanAtlas m{\"o}glich gewesen w{\"a}re. Es hat sich gezeigt, dass dieser Ansatz geeignet ist, um die r{\"a}umliche Verteilung der potenziellen Bodenk{\"u}hlfunktion innerhalb einer Stadt zu untersuchen. Es ist zu beachten, dass der Einfluss des Grundwassers in Remscheid nicht ber{\"u}cksichtigt werden konnte. Denn es ist damit zu rechnen, dass die Grundwasserverh{\"a}ltnisse aufgrund der geologischen und topographischen Situation in Remscheid kleinr{\"a}umig Variationen unterliegen und es somit keinen durchg{\"a}ngigen und kartierten Aquifer gibt. Kleingartenanlagen, Parks und Friedh{\"o}he im innerst{\"a}dtischen Bereich und allgemein die Landnutzungsklassen Wald und Gr{\"u}nland wurden als Fl{\"a}chen mit einem besonders hohem potenziellen Bodenk{\"u}hlpotenzial identifiziert. Solche Fl{\"a}chen sind besonders sch{\"u}tzenswert. Die Analyse der Speicherf{\"u}llst{\"a}nde der oberen Bodenzone, basierend auf der erstellten Karte der potenziellen Bodenk{\"u}hlfunktion und der klimatischen Wasserbilanz, ergab, dass besonders innerst{\"a}dtische Fl{\"a}chen, die einen kleinen Bodenwasserspeicher haben, in einem trockenen Jahr bereits fr{\"u}h im Sommer ihre K{\"u}hlfunktion verlieren und bei Hitzewellen somit eine verringerte positive Klimafunktion haben. Gest{\"u}tzt wird diese Aussage durch eine Auswertung des normalisierten differenzierten Vegetationsindex (NDVI), der genutzt wurde, um die Ver{\"a}nderung der Pflanzenvitalit{\"a}t vor und nach einer Hitzeperiode im Juni/Juli 2018 zu untersuchen. Messungen mit Meteobikes, einer Vorrichtung, die dazu geeignet ist, w{\"a}hrend einer Radfahrt kontinuierlich die Temperatur zu messen, st{\"u}tzen die Erkenntnis, dass innerst{\"a}dtische Gr{\"u}nfl{\"a}chen wie Parks eine positive Wirkung auf das urbane Mikroklima haben. Weiterhin zeigen diese Messungen, dass die Topographie innerhalb des Untersuchungsgebietes die Aufheizung einzelner Fl{\"a}chen und die Temperaturverteilung vermutlich mitbestimmt. Die hier vorgestellte Karte der potenziellen K{\"u}hlfunktion f{\"u}r Remscheid sollte als Erg{\"a}nzung in die Klimafunktionskarte f{\"u}r Remscheid eingehen und den bestehenden Layer „fl{\"a}chenhafte Klimafunktion", der nur die Landnutzung ber{\"u}cksichtigt, ersetzen.}, language = {de} } @article{MarkoetterSintschukBritzkeetal.2022, author = {Mark{\"o}tter, Henning and Sintschuk, Michael and Britzke, Ricardo and Dayani, Shahabeddin and Bruno, Giovanni}, title = {Upgraded imaging capabilities at the BAMline (BESSY II)}, series = {Journal of synchrotron radiation}, volume = {29}, journal = {Journal of synchrotron radiation}, number = {5}, publisher = {International Union of Crystallography}, address = {Chester}, issn = {1600-5775}, doi = {10.1107/S1600577522007342}, pages = {1292 -- 1298}, year = {2022}, abstract = {The BAMline at the BESSY II synchrotron X-ray source has enabled research for more than 20 years in widely spread research fields such as materials science, biology, cultural heritage and medicine. As a nondestructive characterization method, synchrotron X-ray imaging, especially tomography, plays a particularly important role in structural characterization. A recent upgrade of key equipment of the BAMline widens its imaging capabilities: shorter scan acquisition times are now possible, in situ and op erando studies can now be routinely performed, and different energy spectra can easily be set up. In fact, the upgraded double-multilayer monochromator brings full flexibility by yielding different energy spectra to optimize flux and energy resolution as desired. The upgraded detector (based on an sCMOS camera) also allows exploiting the higher flux with reduced readout times. Furthermore, an installed slip ring allows the sample stage to continuously rotate. The latter feature enables tomographic observation of processes occurring in the time scale of a few seconds.}, language = {en} } @article{JonesGonzalezFortesConnelletal.2015, author = {Jones, Eppie R. and Gonz{\´a}lez-Fortes, Gloria M. and Connell, Sarah and Siska, Veronika and Eriksson, Anders and Martiniano, Rui and McLaughlin, Russell L. and Llorente, Marcos Gallego and Cassidy, Lara M. and Gamba, Cristina and Meshveliani, Tengiz and Bar-Yosef, Ofer and Mueller, Werner and Belfer-Cohen, Anna and Matskevich, Zinovi and Jakeli, Nino and Higham, Thomas F. G. and Currat, Mathias and Lordkipanidze, David and Hofreiter, Michael and Manica, Andrea and Pinhasi, Ron and Bradley, Daniel G.}, title = {Upper Palaeolithic genomes reveal deep roots of modern Eurasians}, series = {Nature Communications}, volume = {6}, journal = {Nature Communications}, publisher = {Nature Publishing Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/ncomms9912}, pages = {8}, year = {2015}, abstract = {We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus and a Late Upper Palaeolithic (13,700 years old, 9.5-fold) male from Switzerland. While we detect Late Palaeolithic-Mesolithic genomic continuity in both regions, we find that Caucasus hunter-gatherers (CHG) belong to a distinct ancient clade that split from western hunter-gatherers similar to 45 kya, shortly after the expansion of anatomically modern humans into Europe and from the ancestors of Neolithic farmers similar to 25 kya, around the Last Glacial Maximum. CHG genomes significantly contributed to the Yamnaya steppe herders who migrated into Europe similar to 3,000 BC, supporting a formative Caucasus influence on this important Early Bronze age culture. CHG left their imprint on modern populations from the Caucasus and also central and south Asia possibly marking the arrival of Indo-Aryan languages.}, language = {en} } @article{ZapataSobelDelPapaetal.2020, author = {Zapata, Sebastian and Sobel, Edward and Del Papa, Cecilia and Glodny, Johannes}, title = {Upper Plate Controls on the Formation of Broken Foreland Basins in the Andean Retroarc Between 26°S and 28°S}, series = {Geochemistry, Geophysics, Geosystems}, volume = {21}, journal = {Geochemistry, Geophysics, Geosystems}, number = {7}, publisher = {John Wiley \& Sons, Inc.}, address = {New Jersey}, pages = {22}, year = {2020}, abstract = {Marked along-strike changes in stratigraphy, mountain belt morphology, basement exhumation, and deformation styles characterize the Andean retroarc; these changes have previously been related to spatiotemporal variations in the subduction angle. We modeled new apatite fission track and apatite (U-Th-Sm)/He data from nine ranges located between 26 degrees S and 28 degrees S. Using new and previously published data, we constructed a Cretaceous to Pliocene paleogeographic model that delineates a four-stage tectonic evolution: extensional tectonics during the Cretaceous (120-75 Ma), the formation of a broken foreland basin between 55 and 30 Ma, reheating due to burial beneath sedimentary rocks (18-13 Ma), and deformation, exhumation, and surface uplift during the Late Miocene and the Pliocene (13-3 Ma). Our model highlights how preexisting upper plate structures control the deformation patterns of broken foreland basins. Because retroarc deformation predates flat-slab subduction, we propose that slab anchoring may have been the precursor of Eocene-Oligocene compression in the Andean retroarc. Our model challenges models which consider broken foreland basins and retroarc deformation in the NW Argentinian Andes to be directly related to Miocene flat subduction.}, language = {en} } @incollection{Schmidt2021, author = {Schmidt, Thorsten Ingo}, title = {Urbanisation and local government - an introduction}, series = {Urbanisation and local government(s)}, booktitle = {Urbanisation and local government(s)}, editor = {Hoffman, Istv{\´a}n and Rozsnyai, Krisztina F. and Nagy, Marianna}, publisher = {Institute for Local Self-Government}, address = {Maribor}, isbn = {978-961-7124-06-4}, doi = {10.4335/2021.7}, pages = {5 -- 14}, year = {2021}, abstract = {This introductory essay is structured as follows: First of all, several forms of urbanisation (I.) are introduced and the processes of urbanisation and dis-urbanisation (II.) are defined. Then four fields of law which are deeply affected by urbanisation are put into the focus. These are, local government law (III.), but also public building law (IV.), civil service law (V.) and public finance law (VI.). Afterwards the effects of the corona pandemic on these fields of law are contemplated, taking account of the process of urbanisation (VII.). Finally, the main results are summarised (VIII.).}, language = {en} } @article{ChaykovskaHeunischvonEinemetal.2018, author = {Chaykovska, Lyubov and Heunisch, Fabian and von Einem, Gina and Hocher, Carl-Friedrich and Tsuprykov, Oleg and Pavkovic, Mira and Sandner, Peter and Kretschmer, Axel and Chu, Chang and Elitok, Saban and Stasch, Johannes-Peter and Hocher, Berthold}, title = {Urinary cGMP predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus before exposure to contrast medium}, series = {PLoS one}, volume = {13}, journal = {PLoS one}, number = {4}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0195828}, pages = {13}, year = {2018}, abstract = {Background The use of iodine-based contrast agents entails the risk of contrast induced nephropathy (CIN). Radiocontrast agents elicit the third most common cause of nephropathy among hospitalized patients, accounting for 11-12\% of cases. CIN is connected with clinically significant consequences, including increased morbidity, prolonged hospitalization, increased risk of complications, potential need for dialysis, and increased mortality rate. The number of in hospital examinations using iodine-based contrast media has been significantly increasing over the last decade. In order to protect patients from possible complications of such examinations, new biomarkers are needed that are able to predict a risk of contrast-induced nephropathy. Urinary and plasma cyclic guanosine monophosphate (cGMP) concentrations are influenced by renal function. Urinary cGMP is primarily of renal cellular origin. Therefore, we assessed if urinary cGMP concentration may predict major adverse renal events (MARE) after contrast media exposure during coronary angiography. Methods Urine samples were prospectively collected from non-randomized consecutive patients with either diabetes or preexisting impaired kidney function receiving intra-arterial contrast medium (CM) for emergent or elective coronary angiography at the Charite Campus Mitte, University Hospital Berlin. Urinary cGMP concentration in spot urine was analyzed 24 hours after CM exposure. Patients were followed up over 90 days for occurrence of death, initiation of dialysis, doubling of plasma creatinine concentration or MARE. Results In total, 289 consecutive patients were included into the study. Urine cGMP/creatinine ratio 24 hours before CM exposure expressed as mean +/- SD was predictive for the need of dialysis (no dialysis: 89.77 +/- 92.85 mu M/mM, n = 277; need for dialysis: 140.3 +/- 82.90 mu M/mM, n = 12, p = 0.008), death (no death during follow-up: 90.60 +/- 92.50 mu M/mM, n = 280; death during follow-up: 169.88 +/- 81.52 mu M/mM, n = 9; p = 0.002), and the composite endpoint MARE (no MARE: 86.02 +/- 93.17 mu M/mM, n = 271; MARE: 146.64 +/- 74.68 mu M/mM, n = 18, p<0.001) during the follow-up of 90 days after contrast media application. cGMP/creatinine ratio stayed significantly increased at values exceeding 120 pM/mM in patients who developed MARE, required dialysis or died. Conclusions Urinary cGMP/creatinine ratio >= 120 mu M/mM before CM exposure is a promising biomarker for the need of dialysis and all-cause mortality 90 days after CM exposure in patients with preexisting renal impairment or diabetes.}, language = {en} } @article{MetjeLeverMayeretal.2020, author = {Metje, Jan and Lever, Fabiano and Mayer, Dennis and Squibb, Richard James and Robinson, Matthew Scott and Niebuhr, Mario and Feifel, Raimund and D{\"u}sterer, Stefan and G{\"u}hr, Markus}, title = {URSA-PQ}, series = {Applied Sciences}, volume = {10}, journal = {Applied Sciences}, number = {21}, publisher = {MDPI}, address = {Basel}, issn = {2076-3417}, doi = {10.3390/app10217882}, pages = {13}, year = {2020}, abstract = {We present a highly flexible and portable instrument to perform pump-probe spectroscopy with an optical and an X-ray pulse in the gas phase. The so-called URSA-PQ (German for 'Ultraschnelle R{\"o}ntgenspektroskopie zur Abfrage der Photoenergiekonversion an Quantensystemen', Engl. 'ultrafast X-ray spectroscopy for probing photoenergy conversion in quantum systems') instrument is equipped with a magnetic bottle electron spectrometer (MBES) and tools to characterize the spatial and temporal overlap of optical and X-ray laser pulses. Its adherence to the CAMP instrument dimensions allows for a wide range of sample sources as well as other spectrometers to be included in the setup. We present the main design and technical features of the instrument. The MBES performance was evaluated using Kr M4,5NN Auger lines using backfilled Kr gas, with an energy resolution ΔE/E ≅ 1/40 in the integrating operative mode. The time resolution of the setup at FLASH 2 FL 24 has been characterized with the help of an experiment on 2-thiouracil that is inserted via the instruments' capillary oven. We find a time resolution of 190 fs using the molecular 2p photoline shift and attribute this to different origins in the UV-pump—the X-ray probe setup.}, language = {en} } @article{GrafenSchumacherChithelenetal.2019, author = {Grafen, Anika and Schumacher, Fabian and Chithelen, Janice and Kleuser, Burkhard and Beyersdorf, Niklas and Schneider-Schaulies, J{\"u}rgen}, title = {Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro}, series = {Frontiers in Cell and Developmental Biology}, volume = {7}, journal = {Frontiers in Cell and Developmental Biology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {2296-634X}, doi = {10.3389/fcell.2019.00218}, pages = {14}, year = {2019}, abstract = {As structural membrane components and signaling effector molecules sphingolipids influence a plethora of host cell functions, and by doing so also the replication of viruses. Investigating the effects of various inhibitors of sphingolipid metabolism in primary human peripheral blood lymphocytes (PBL) and the human B cell line BJAB we found that not only the sphingosine kinase (SphK) inhibitor SKI-II, but also the acid ceramidase inhibitor ceranib-2 efficiently inhibited measles virus (MV) replication. Virus uptake into the target cells was not grossly altered by the two inhibitors, while titers of newly synthesized MV were reduced by approximately 1 log (90\%) in PBL and 70-80\% in BJAB cells. Lipidomic analyses revealed that in PBL SKI-II led to increased ceramide levels, whereas in BJAB cells ceranib-2 increased ceramides. SKI-II treatment decreased sphingosine-1-phosphate (S1P) levels in PBL and BJAB cells. Furthermore, we found that MV infection of lymphocytes induced a transient (0.5-6 h) increase in S1P, which was prevented by SKI-II. Investigating the effect of the inhibitors on the metabolic (mTORC1) activity we found that ceranib-2 reduced the phosphorylation of p70 S6K in PBL, and that both inhibitors, ceranib-2 and SKI-II, reduced the phosphorylation of p70 S6K in BJAB cells. As mTORC1 activity is required for efficient MV replication, this effect of the inhibitors is one possible antiviral mechanism. In addition, reduced intracellular S1P levels affect a number of signaling pathways and functions including Hsp90 activity, which was reported to be required for MV replication. Accordingly, we found that pharmacological inhibition of Hsp90 with the inhibitor 17-AAG strongly impaired MV replication in primary PBL. Thus, our data suggest that treatment of lymphocytes with both, acid ceramidase and SphK inhibitors, impair MV replication by affecting a number of cellular activities including mTORC1 and Hsp90, which alter the metabolic state of the cells causing a hostile environment for the virus.}, language = {en} } @article{RigamontiEstelGehlenetal.2021, author = {Rigamonti, Lia and Estel, Katharina and Gehlen, Tobias and Wolfarth, Bernd and Lawrence, James B. and Back, David A.}, title = {Use of artificial intelligence in sports medicine}, series = {BMC Sports Science, Medicine \& Rehabilitation}, volume = {13}, journal = {BMC Sports Science, Medicine \& Rehabilitation}, publisher = {BioMed Central}, address = {London}, issn = {2052-1847}, doi = {10.1186/s13102-021-00243-x}, pages = {17}, year = {2021}, abstract = {Background Artificial intelligence (AI) is one of the most promising areas in medicine with many possibilities for improving health and wellness. Already today, diagnostic decision support systems may help patients to estimate the severity of their complaints. This fictional case study aimed to test the diagnostic potential of an AI algorithm for common sports injuries and pathologies. Methods Based on a literature review and clinical expert experience, five fictional "common" cases of acute, and subacute injuries or chronic sport-related pathologies were created: Concussion, ankle sprain, muscle pain, chronic knee instability (after ACL rupture) and tennis elbow. The symptoms of these cases were entered into a freely available chatbot-guided AI app and its diagnoses were compared to the pre-defined injuries and pathologies. Results A mean of 25-36 questions were asked by the app per patient, with optional explanations of certain questions or illustrative photos on demand. It was stressed, that the symptom analysis would not replace a doctor's consultation. A 23-yr-old male patient case with a mild concussion was correctly diagnosed. An ankle sprain of a 27-yr-old female without ligament or bony lesions was also detected and an ER visit was suggested. Muscle pain in the thigh of a 19-yr-old male was correctly diagnosed. In the case of a 26-yr-old male with chronic ACL instability, the algorithm did not sufficiently cover the chronic aspect of the pathology, but the given recommendation of seeing a doctor would have helped the patient. Finally, the condition of the chronic epicondylitis in a 41-yr-old male was correctly detected. Conclusions All chosen injuries and pathologies were either correctly diagnosed or at least tagged with the right advice of when it is urgent for seeking a medical specialist. However, the quality of AI-based results could presumably depend on the data-driven experience of these programs as well as on the understanding of their users. Further studies should compare existing AI programs and their diagnostic accuracy for medical injuries and pathologies.}, language = {en} } @article{Knigge2020, author = {Knigge, Michel}, title = {Use of evidence to promote inclusive education development commentary on Mel Ainscow. Promoting inclusion and equity in education}, series = {Nordic Journal of Studies in Educational Policy}, volume = {6}, journal = {Nordic Journal of Studies in Educational Policy}, number = {1}, publisher = {Taylor \& Francis Group}, address = {London}, issn = {2002-0317}, doi = {10.1080/20020317.2020.1730093}, pages = {21 -- 24}, year = {2020}, abstract = {In his essay, Mel Ainscow looks at inclusion and equity from an international perspective and makes suggestions on how to develop inclusive education in a 'whole-system approach'. After discussing different conceptions of inclusion and equity, he describes international policies which address them. From this international macro-level, Ainscow zooms in to the meso-level of the school and its immediate environment, defining dimensions to be considered for an inclusive school development. One of these dimensions is the 'use of evidence'. In my comment, I want to focus on this dimension and discuss its scope and the potential to apply it in inclusive education development. As a first and important precondition, Ainscow explains that different circumstances lead to different linguistic uses of the term 'inclusive education'. Thus, the term 'inclusive education' does not refer to an identical set of objectives across countries, and neither does the term 'equity'.}, language = {en} }