@article{HerrmannBodenMaureretal.2022, author = {Herrmann, Matthias L. and Boden, Cindy and Maurer, Christoph and Kentischer, Felix and Mennig, Eva and Wagner, S{\"o}ren and Conzelmann, Lars O. and F{\"o}rstner, Bernd R. and Rapp, Michael A. and von Arnim, Christine A. F. and Denkinger, Michael and Eschweiler, Gerhard W. and Thomas, Christine}, title = {Anticholinergic drug exposure increases the risk of delirium in older patients undergoing elective surgery}, series = {Frontiers in medicine}, volume = {9}, journal = {Frontiers in medicine}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-858X}, doi = {10.3389/fmed.2022.871229}, pages = {8}, year = {2022}, abstract = {IntroductionPostoperative delirium (POD) is a common and serious adverse event of surgery in older people. Because of its great impact on patients' safety and quality of life, identification of modifiable risk factors could be useful. Although preoperative medication intake is assumed to be an important modifiable risk factor, the impact of anticholinergic drugs on the occurrence of POD seems underestimated in elective surgery. The aim of this study was to investigate the association between preoperative anticholinergic burden and POD. We hypothesized that a high preoperative anticholinergic burden is an independent, potentially modifiable predisposing and precipitating factor of POD in older people. MethodsBetween November 2017 and April 2019, 1,470 patients of 70 years and older undergoing elective orthopedic, general, cardiac, or vascular surgery were recruited in the randomized, prospective, multicenter PAWEL trial. Anticholinergic burden of a sub-cohort of 899 patients, who did not receive a multimodal intervention for preventing POD, was assessed by two different tools at hospital admission: The established Anticholinergic Risk Scale (ARS) and the recently developed Anticholinergic Burden Score (ABS). POD was detected by confusion assessment method (CAM) and a validated post discharge medical record review. Logistic regression analyses were performed to evaluate the association between anticholinergic burden and POD. ResultsPOD was observed in 210 of 899 patients (23.4\%). Both ARS and ABS were independently associated with POD. The association persisted after adjustment for relevant confounding factors such as age, sex, comorbidities, preoperative cognitive and physical status, number of prescribed drugs, surgery time, type of surgery and anesthesia, usage of heart-lung-machine, and treatment in intensive care unit. If a patient was taking one of the 56 drugs listed in the ABS, risk for POD was 2.7-fold higher (OR = 2.74, 95\% CI = 1.55-4.94) and 1.5-fold higher per additional point on the ARS (OR = 1.54, 95\% CI = 1.15-2.02). ConclusionPreoperative anticholinergic drug exposure measured by ARS or ABS was independently associated with POD in older patients undergoing elective surgery. Therefore, identification, discontinuation or substitution of anticholinergic medication prior to surgery may be a promising approach to reduce the risk of POD in older patients.}, language = {en} } @article{HoangMertensWessigetal.2018, author = {Hoang, Hoa T. and Mertens, Monique and Wessig, Pablo and Sellrie, Frank and Schenk, J{\"o}rg A. and Kumke, Michael Uwe}, title = {Antibody Binding at the Liposome-Water Interface}, series = {ACS Omega}, volume = {3}, journal = {ACS Omega}, number = {12}, publisher = {American Chemical Society}, address = {Washington}, issn = {2470-1343}, doi = {10.1021/acsomega.8b03016}, pages = {18109 -- 18116}, year = {2018}, abstract = {Different signal amplification strategies to improve the detection sensitivity of immunoassays have been applied which utilize enzymatic reactions, nanomaterials, or liposomes. The latter are very attractive materials for signal amplification because liposomes can be loaded with a large amount of signaling molecules, leading to a high sensitivity. In addition, liposomes can be used as a cell-like "bioscaffold" to directly test recognition schemes aiming at cell-related processes. This study demonstrates an easy and fast approach to link the novel hydrophobic optical probe based on [1,3]dioxolo[4,5-f]-[1,3]benzodioxole (DBD dye mm239) with tunable optical properties to hydrophilic recognition elements (e.g., antibodies) using liposomes for signal amplification and as carrier of the hydrophobic dye. The fluorescence properties of mm239 (e.g., long fluorescence lifetime, large Stokes shift, high photostability, and high quantum yield), its high hydrophobicity for efficient anchoring in liposomes, and a maleimide bioreactive group were applied in a unique combination to build a concept for the coupling of antibodies or other protein markers to liposomes (coupling to membranes can be envisaged). The concept further allowed us to avoid multiple dye labeling of the antibody. Here, anti-TAMRA-antibody (DC7-Ab) was attached to the liposomes. In proof-of-concept, steady-state as well as time-resolved fluorescence measurements (e.g., fluorescence depolarization) in combination with single molecule detection (fluorescence correlation spectroscopy, FCS) were used to analyze the binding interaction between DC7-Ab and liposomes as well as the binding of the antigen rhodamine 6G (R6G) to the antibody. Here, the Forster resonance energy transfer (FRET) between mm239 and R6G was monitored. In addition to ensemble FRET data, single-molecule FRET (PIE-FRET) experiments using pulsed interleaved excitation were used to characterize in detail the binding on a single-molecule level to avoid averaging out effects.}, language = {en} } @incollection{Balderjahn2022, author = {Balderjahn, Ingo}, title = {Anti-Consumption und Nachhaltigkeit}, series = {Marke, Nachhaltigkeit und Verbraucherpolitik : Die Gew{\"a}hrleistungsmarke im Spannungsfeld zwischen Unternehmen, Konsumenten und Regulierung}, booktitle = {Marke, Nachhaltigkeit und Verbraucherpolitik : Die Gew{\"a}hrleistungsmarke im Spannungsfeld zwischen Unternehmen, Konsumenten und Regulierung}, editor = {Boltz, Dirk-Mario and Bruhn, Manfred and Gr{\"o}ppel-Klein, Andrea and Hellmann, Kai-Uwe}, publisher = {Nomos}, address = {Baden-Baden}, isbn = {978-3-7489-1271-2}, doi = {10.5771/9783748912712-29}, pages = {29 -- 40}, year = {2022}, language = {de} } @article{ZiesemerHuettelBalderjahn2019, author = {Ziesemer, Florence and H{\"u}ttel, Alexandra and Balderjahn, Ingo}, title = {Anti-Consumption}, series = {Sustainability}, volume = {11}, journal = {Sustainability}, number = {23}, publisher = {MDPI}, address = {Basel}, issn = {2071-1050}, doi = {10.3390/su11236663}, pages = {16}, year = {2019}, abstract = {Transcending the conventional debate around efficiency in sustainable consumption, anti-consumption patterns leading to decreased levels of material consumption have been gaining importance. Change agents are crucial for the promotion of such patterns, so there may be lessons for governance interventions that can be learnt from the every-day experiences of those who actively implement and promote sustainability in the field of anti-consumption. Eighteen social innovation pioneers, who engage in and diffuse practices of voluntary simplicity and collaborative consumption as sustainable options of anti-consumption share their knowledge and personal insights in expert interviews for this research. Our qualitative content analysis reveals drivers, barriers, and governance strategies to strengthen anti-consumption patterns, which are negotiated between the market, the state, and civil society. Recommendations derived from the interviews concern entrepreneurship, municipal infrastructures in support of local grassroots projects, regulative policy measures, more positive communication to strengthen the visibility of initiatives and emphasize individual benefits, establishing a sense of community, anti-consumer activism, and education. We argue for complementary action between top-down strategies, bottom-up initiatives, corporate activities, and consumer behavior. The results are valuable to researchers, activists, marketers, and policymakers who seek to enhance their understanding of materially reduced consumption patterns based on the real-life experiences of active pioneers in the field.}, language = {en} } @article{Petersen2023, author = {Petersen, Jens}, title = {Anthropozentrik und {\"O}kozentrik im Umweltrecht}, series = {Studien zur juristischen Ideengeschichte}, journal = {Studien zur juristischen Ideengeschichte}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-543-9}, doi = {10.25932/publishup-60430}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-604303}, pages = {149 -- 160}, year = {2023}, language = {de} } @article{Crane2019, author = {Crane, Kylie Ann}, title = {Anthropocene Presences and the Limits of Deferral}, series = {Open library of humanities}, volume = {5}, journal = {Open library of humanities}, number = {1}, publisher = {Open library of humanities}, address = {Cambridge}, issn = {2056-6700}, doi = {10.16995/olh.348}, pages = {24}, year = {2019}, abstract = {Literary criticism, particularly ecocriticism, occupies an uneasy position with regard to activism: reading books (or plays, or poems) seems like a rather leisurely activity to be undertaking if our environment—our planet—is in crisis. And yet, critiquing the narratives that structure worlds and discourses is key to the activities of the (literary) critic in this time of crisis. If this crisis manifests as a 'crisis of imagination' (e.g. Ghosh), I argue that this not so much a crisis of the absence of texts that address the environmental disaster, but rather a failure to comprehend the presences of the Anthropocene in the present. To interpret (literary) texts in this framework must entail acknowledging and scrutinising the extent of the incapacity of the privileged reader to comprehend the crisis as presence and present rather than spatially or temporally remote. The readings of the novels Carpentaria (2006) and The Swan Book (2013) by Waanyi writer Alexis Wright (Australia) trace the uneven presences of Anthropocenes in the present by way of bringing future worlds (The Swan Book) to the contemporary (Carpentaria). In both novels, protagonists must forge survival amongst ruins of the present and future: the depicted worlds, in particular the representations of the disenfranchisement of indigenous inhabitants of the far north of the Australian continent, emerge as a critique of the intersections of capitalist and colonial projects that define modernity and its impact on the global climate.}, language = {en} } @article{AgtheKayserSchwarzetal.2023, author = {Agthe, Maria and Kayser, Daniela Niesta and Schwarz, Sascha and Maner, Jon K.}, title = {Antecedents of the red-romance effect}, series = {PLOS ONE / Public Library of Science}, volume = {18}, journal = {PLOS ONE / Public Library of Science}, number = {4}, publisher = {PLOS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0284035}, pages = {19}, year = {2023}, abstract = {The color red has been implicated in a variety of social processes, including those involving mating. While previous research suggests that women sometimes wear red strategically to increase their attractiveness, the replicability of this literature has been questioned. The current research is a reasonably powered conceptual replication designed to strengthen this literature by testing whether women are more inclined to display the color red 1) during fertile (as compared with less fertile) days of the menstrual cycle, and 2) when expecting to interact with an attractive man (as compared with a less attractive man and with a control condition). Analyses controlled for a number of theoretically relevant covariates (relationship status, age, the current weather). Only the latter hypothesis received mixed support (mainly among women on hormonal birth control), whereas results concerning the former hypothesis did not reach significance. Women (N = 281) displayed more red when expecting to interact with an attractive man; findings did not support the prediction that women would increase their display of red on fertile days of the cycle. Findings thus suggested only mixed replicability for the link between the color red and psychological processes involving romantic attraction. They also illustrate the importance of further investigating the boundary conditions of color effects on everyday social processes.}, language = {en} } @article{ReeseAlbrechtMengeletal.2018, author = {Reese, Ronja and Albrecht, Torsten and Mengel, Matthias and Asay-Davis, Xylar and Winkelmann, Ricarda}, title = {Antarctic sub-shelf melt rates via PICO}, series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, volume = {12}, journal = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union}, number = {6}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1994-0416}, doi = {10.5194/tc-12-1969-2018}, pages = {1969 -- 1985}, year = {2018}, abstract = {Ocean-induced melting below ice shelves is one of the dominant drivers for mass loss from the Antarctic Ice Sheet at present. An appropriate representation of sub-shelf melt rates is therefore essential for model simulations of marine-based ice sheet evolution. Continental-scale ice sheet models often rely on simple melt-parameterizations, in particular for long-term simulations, when fully coupled ice-ocean interaction becomes computationally too expensive. Such parameterizations can account for the influence of the local depth of the ice-shelf draft or its slope on melting. However, they do not capture the effect of ocean circulation underneath the ice shelf. Here we present the Potsdam Ice-shelf Cavity mOdel (PICO), which simulates the vertical overturning circulation in ice-shelf cavities and thus enables the computation of sub-shelf melt rates consistent with this circulation. PICO is based on an ocean box model that coarsely resolves ice shelf cavities and uses a boundary layer melt formulation. We implement it as a module of the Parallel Ice Sheet Model (PISM) and evaluate its performance under present-day conditions of the Southern Ocean. We identify a set of parameters that yield two-dimensional melt rate fields that qualitatively reproduce the typical pattern of comparably high melting near the grounding line and lower melting or refreezing towards the calving front. PICO captures the wide range of melt rates observed for Antarctic ice shelves, with an average of about 0.1 ma(-1) for cold sub-shelf cavities, for example, underneath Ross or Ronne ice shelves, to 16 ma(-1) for warm cavities such as in the Amundsen Sea region. This makes PICO a computationally feasible and more physical alternative to melt parameterizations purely based on ice draft geometry.}, language = {en} } @article{IlicicWoodhouseKarstenetal.2022, author = {Ilicic, Doris and Woodhouse, Jason Nicholas and Karsten, Ulf and Zimmermann, Jonas and Wichard, Thomas and Quartino, Maria Liliana and Campana, Gabriela Laura and Livenets, Alexandra and Van den Wyngaert, Silke and Grossart, Hans-Peter}, title = {Antarctic Glacial Meltwater Impacts the Diversity of Fungal Parasites Associated With Benthic Diatoms in Shallow Coastal Zones}, series = {Frontiers in microbiology}, journal = {Frontiers in microbiology}, number = {13}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-302X}, doi = {10.3389/fmicb.2022.805694}, pages = {12}, year = {2022}, abstract = {Aquatic ecosystems are frequently overlooked as fungal habitats, although there is increasing evidence that their diversity and ecological importance are greater than previously considered. Aquatic fungi are critical and abundant components of nutrient cycling and food web dynamics, e.g., exerting top-down control on phytoplankton communities and forming symbioses with many marine microorganisms. However, their relevance for microphytobenthic communities is almost unexplored. In the light of global warming, polar regions face extreme changes in abiotic factors with a severe impact on biodiversity and ecosystem functioning. Therefore, this study aimed to describe, for the first time, fungal diversity in Antarctic benthic habitats along the salinity gradient and to determine the co-occurrence of fungal parasites with their algal hosts, which were dominated by benthic diatoms. Our results reveal that Ascomycota and Chytridiomycota are the most abundant fungal taxa in these habitats. We show that also in Antarctic waters, salinity has a major impact on shaping not just fungal but rather the whole eukaryotic community composition, with a diversity of aquatic fungi increasing as salinity decreases. Moreover, we determined correlations between putative fungal parasites and potential benthic diatom hosts, highlighting the need for further systematic analysis of fungal diversity along with studies on taxonomy and ecological roles of Chytridiomycota.}, language = {en} } @article{BittmannDechSchaefer2023, author = {Bittmann, Frank and Dech, Silas and Schaefer, Laura}, title = {Another way to confuse motor control}, series = {Brain Sciences}, volume = {13}, journal = {Brain Sciences}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2076-3425}, doi = {10.3390/brainsci13071105}, pages = {20}, year = {2023}, abstract = {Sensorimotor control can be impaired by slacked muscle spindles. This was shown for reflex responses and, recently, also for muscular stability in the sense of Adaptive Force (AF). The slack in muscle spindles was generated by contracting the lengthened muscle followed by passive shortening. AF was suggested to specifically reflect sensorimotor control since it requires tension-length control in adaptation to an increasing load. This study investigated AF parameters in reaction to another, manually performed slack procedure in a preselected sample (n = 13). The AF of 11 elbow and 12 hip flexors was assessed by an objectified manual muscle test (MMT) using a handheld device. Maximal isometric AF was significantly reduced after manual spindle technique vs. regular MMT. Muscle lengthening started at 64.93 \& PLUSMN; 12.46\% of maximal voluntary isometric contraction (MVIC). During regular MMT, muscle length could be maintained stable until 92.53 \& PLUSMN; 10.12\% of MVIC. Hence, muscular stability measured by AF was impaired after spindle manipulation. Force oscillations arose at a significantly lower level for regular vs. spindle. This supports the assumption that they are a prerequisite for stable adaptation. Reduced muscular stability in reaction to slack procedures is considered physiological since sensory information is misled. It is proposed to use slack procedures to test the functionality of the neuromuscular system, which is relevant for clinical practice.}, language = {en} }