@article{SoechtingTrapp2020, author = {S{\"o}chting, Maximilian and Trapp, Matthias}, title = {Controlling image-stylization techniques using eye tracking}, series = {Science and Technology Publications}, journal = {Science and Technology Publications}, publisher = {Springer}, address = {Berlin}, issn = {2184-4321}, pages = {10}, year = {2020}, abstract = {With the spread of smart phones capable of taking high-resolution photos and the development of high-speed mobile data infrastructure, digital visual media is becoming one of the most important forms of modern communication. With this development, however, also comes a devaluation of images as a media form with the focus becoming the frequency at which visual content is generated instead of the quality of the content. In this work, an interactive system using image-abstraction techniques and an eye tracking sensor is presented, which allows users to experience diverting and dynamic artworks that react to their eye movement. The underlying modular architecture enables a variety of different interaction techniques that share common design principles, making the interface as intuitive as possible. The resulting experience allows users to experience a game-like interaction in which they aim for a reward, the artwork, while being held under constraints, e.g., not blinking. The co nscious eye movements that are required by some interaction techniques hint an interesting, possible future extension for this work into the field of relaxation exercises and concentration training.}, language = {en} } @article{ThienenWeinsteinMeinel2023, author = {Thienen, Julia von and Weinstein, Theresa Julia and Meinel, Christoph}, title = {Creative metacognition in design thinking}, series = {Frontiers in psychology}, volume = {14}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2023.1157001}, pages = {20}, year = {2023}, abstract = {Design thinking is a well-established practical and educational approach to fostering high-level creativity and innovation, which has been refined since the 1950s with the participation of experts like Joy Paul Guilford and Abraham Maslow. Through real-world projects, trainees learn to optimize their creative outcomes by developing and practicing creative cognition and metacognition. This paper provides a holistic perspective on creativity, enabling the formulation of a comprehensive theoretical framework of creative metacognition. It focuses on the design thinking approach to creativity and explores the role of metacognition in four areas of creativity expertise: Products, Processes, People, and Places. The analysis includes task-outcome relationships (product metacognition), the monitoring of strategy effectiveness (process metacognition), an understanding of individual or group strengths and weaknesses (people metacognition), and an examination of the mutual impact between environments and creativity (place metacognition). It also reviews measures taken in design thinking education, including a distribution of cognition and metacognition, to support students in their development of creative mastery. On these grounds, we propose extended methods for measuring creative metacognition with the goal of enhancing comprehensive assessments of the phenomenon. Proposed methodological advancements include accuracy sub-scales, experimental tasks where examinees explore problem and solution spaces, combinations of naturalistic observations with capability testing, as well as physiological assessments as indirect measures of creative metacognition.}, language = {en} } @article{OmotoshoAyegbaEmuoyibofarheetal.2019, author = {Omotosho, Adebayo and Ayegba, Peace and Emuoyibofarhe, Justice and Meinel, Christoph}, title = {Current State of ICT in Healthcare Delivery in Developing Countries}, series = {International Journal of Online and Biomedical Engineering}, volume = {15}, journal = {International Journal of Online and Biomedical Engineering}, number = {8}, publisher = {Kassel University Press}, address = {Kassel}, issn = {2626-8493}, doi = {10.3991/ijoe.v15i08.10294}, pages = {91 -- 107}, year = {2019}, abstract = {Electronic health is one of the most popular applications of information and communication technologies and it has contributed immensely to health delivery through the provision of quality health service and ubiquitous access at a lower cost. Even though this mode of health service is increasingly becoming known or used in developing nations, these countries are faced with a myriad of challenges when implementing and deploying e-health services on both small and large scale. It is estimated that the Africa population alone carries the highest percentage of the world's global diseases despite its certain level of e-health adoption. This paper aims at analyzing the progress so far and the current state of e-health in developing countries particularly Africa and propose a framework for further improvement.}, language = {en} } @book{BartzKrestel2021, author = {Bartz, Christian and Krestel, Ralf}, title = {Deep learning for computer vision in the art domain}, number = {139}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-514-9}, issn = {1613-5652}, doi = {10.25932/publishup-51290}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-512906}, publisher = {Universit{\"a}t Potsdam}, pages = {vii, 79}, year = {2021}, abstract = {In recent years, computer vision algorithms based on machine learning have seen rapid development. In the past, research mostly focused on solving computer vision problems such as image classification or object detection on images displaying natural scenes. Nowadays other fields such as the field of cultural heritage, where an abundance of data is available, also get into the focus of research. In the line of current research endeavours, we collaborated with the Getty Research Institute which provided us with a challenging dataset, containing images of paintings and drawings. In this technical report, we present the results of the seminar "Deep Learning for Computer Vision". In this seminar, students of the Hasso Plattner Institute evaluated state-of-the-art approaches for image classification, object detection and image recognition on the dataset of the Getty Research Institute. The main challenge when applying modern computer vision methods to the available data is the availability of annotated training data, as the dataset provided by the Getty Research Institute does not contain a sufficient amount of annotated samples for the training of deep neural networks. However, throughout the report we show that it is possible to achieve satisfying to very good results, when using further publicly available datasets, such as the WikiArt dataset, for the training of machine learning models.}, language = {en} } @article{ZieglerPfitznerSchulzetal.2022, author = {Ziegler, Joceline and Pfitzner, Bjarne and Schulz, Heinrich and Saalbach, Axel and Arnrich, Bert}, title = {Defending against Reconstruction Attacks through Differentially Private Federated Learning for Classification of Heterogeneous Chest X-ray Data}, series = {Sensors}, volume = {22}, journal = {Sensors}, edition = {14}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {1424-8220}, doi = {10.3390/s22145195}, pages = {25}, year = {2022}, abstract = {Privacy regulations and the physical distribution of heterogeneous data are often primary concerns for the development of deep learning models in a medical context. This paper evaluates the feasibility of differentially private federated learning for chest X-ray classification as a defense against data privacy attacks. To the best of our knowledge, we are the first to directly compare the impact of differentially private training on two different neural network architectures, DenseNet121 and ResNet50. Extending the federated learning environments previously analyzed in terms of privacy, we simulated a heterogeneous and imbalanced federated setting by distributing images from the public CheXpert and Mendeley chest X-ray datasets unevenly among 36 clients. Both non-private baseline models achieved an area under the receiver operating characteristic curve (AUC) of 0.940.94 on the binary classification task of detecting the presence of a medical finding. We demonstrate that both model architectures are vulnerable to privacy violation by applying image reconstruction attacks to local model updates from individual clients. The attack was particularly successful during later training stages. To mitigate the risk of a privacy breach, we integrated R{\´e}nyi differential privacy with a Gaussian noise mechanism into local model training. We evaluate model performance and attack vulnerability for privacy budgets ε∈{1,3,6,10}�∈{1,3,6,10}. The DenseNet121 achieved the best utility-privacy trade-off with an AUC of 0.940.94 for ε=6�=6. Model performance deteriorated slightly for individual clients compared to the non-private baseline. The ResNet50 only reached an AUC of 0.760.76 in the same privacy setting. Its performance was inferior to that of the DenseNet121 for all considered privacy constraints, suggesting that the DenseNet121 architecture is more robust to differentially private training.}, language = {en} } @article{GiannatelliTomasini2023, author = {Giannatelli, Ada and Tomasini, Alessandra}, title = {Descriptors and EU Standards to support the recognition of MOOCs}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62396}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-623967}, pages = {133 -- 146}, year = {2023}, abstract = {Digital technologies have enabled a variety of learning offers that opened new challenges in terms of recognition of formal, informal and non-formal learning, such as MOOCs. This paper focuses on how providing relevant data to describe a MOOC is conducive to increase the transparency of information and, ultimately, the flexibility of European higher education. The EU-funded project ECCOE took up these challenges and developed a solution by identifying the most relevant descriptors of a learning opportunity with a view to supporting a European system for micro-credentials. Descriptors indicate the specific properties of a learning opportunity according to European standards. They can provide a recognition framework also for small volumes of learning (micro-credentials) to support the integration of non-formal learning (MOOCs) into formal learning (e.g. institutional university courses) and to tackle skills shortage, upskilling and reskilling by acquiring relevant competencies. The focus on learning outcomes can facilitate the recognition of skills and competences of students and enhance both virtual and physical mobility and employability. This paper presents two contexts where ECCOE descriptors have been adopted: the Politecnico di Milano MOOC platform (Polimi Open Knowledge - POK), which is using these descriptors as the standard information to document the features of its learning opportunities, and the EU-funded Uforest project on urban forestry, which developed a blended training program for students of partner universities whose MOOCs used the ECCOE descriptors. Practice with ECCOE descriptors shows how they can be used not only to detail MOOC features, but also as a compass to design the learning offer. In addition, some rules of thumb can be derived and applied when using specific descriptors.}, language = {en} } @book{GerkenUebernickeldePaula2022, author = {Gerken, Stefanie and Uebernickel, Falk and de Paula, Danielly}, title = {Design Thinking: a Global Study on Implementation Practices in Organizations}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-525-5}, doi = {10.25932/publishup-53466}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-534668}, publisher = {Universit{\"a}t Potsdam}, pages = {230}, year = {2022}, abstract = {These days design thinking is no longer a "new approach". Among practitioners, as well as academics, interest in the topic has gathered pace over the last two decades. However, opinions are divided over the longevity of the phenomenon: whether design thinking is merely "old wine in new bottles," a passing trend, or still evolving as it is being spread to an increasing number of organizations and industries. Despite its growing relevance and the diffusion of design thinking, knowledge on the actual status quo in organizations remains scarce. With a new study, the research team of Prof. Uebernickel and Stefanie Gerken investigates temporal developments and changes in design thinking practices in organizations over the past six years comparing the results of the 2015 "Parts without a whole" study with current practices and future developments. Companies of all sizes and from different parts of the world participated in the survey. The findings from qualitative interviews with experts, i.e., people who have years of knowledge with design thinking, were cross-checked with the results from an exploratory analysis of the survey data. This analysis uncovers significant variances and similarities in how design thinking is interpreted and applied in businesses.}, language = {en} } @book{MeinelJohnWollowski2022, author = {Meinel, Christoph and John, Catrina and Wollowski, Tobias}, title = {Die HPI Schul-Cloud - Von der Vision zur digitale Infrastruktur f{\"u}r deutsche Schulen}, number = {144}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-526-2}, issn = {1613-5652}, doi = {10.25932/publishup-53586}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-535860}, publisher = {Universit{\"a}t Potsdam}, pages = {v, 77}, year = {2022}, abstract = {Digitale Medien sind aus unserem Alltag kaum noch wegzudenken. Einer der zentralsten Bereiche f{\"u}r unsere Gesellschaft, die schulische Bildung, darf hier nicht hintanstehen. Wann immer der Einsatz digital unterst{\"u}tzter Tools p{\"a}dagogisch sinnvoll ist, muss dieser in einem sicheren Rahmen erm{\"o}glicht werden k{\"o}nnen. Die HPI Schul-Cloud ist dieser Vision gefolgt, die vom Nationalen IT-Gipfel 2016 angestoßen wurde und dem Bericht vorangestellt ist - gefolgt. Sie hat sich in den vergangenen f{\"u}nf Jahren vom Pilotprojekt zur unverzichtbaren IT-Infrastruktur f{\"u}r zahlreiche Schulen entwickelt. W{\"a}hrend der Corona-Pandemie hat sie f{\"u}r viele Tausend Schulen wichtige Unterst{\"u}tzung bei der Umsetzung ihres Bildungsauftrags geboten. Das Ziel, eine zukunftssichere und datenschutzkonforme Infrastruktur zur digitalen Unterst{\"u}tzung des Unterrichts zur Verf{\"u}gung zu stellen, hat sie damit mehr als erreicht. Aktuell greifen rund 1,4 Millionen Lehrkr{\"a}fte und Sch{\"u}lerinnen und Sch{\"u}ler bundesweit und an den deutschen Auslandsschulen auf die HPI Schul-Cloud zu.}, language = {de} } @article{MihaescuAndoneVasiu2021, author = {Mihaescu, Vlad and Andone, Diana and Vasiu, Radu}, title = {DigiCulture MOOC Courses Piloting with Students}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51733}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517339}, pages = {275 -- 279}, year = {2021}, language = {en} } @book{MeinelGalbasHageboelling2023, author = {Meinel, Christoph and Galbas, Michael and Hageb{\"o}lling, David}, title = {Digital sovereignty: insights from Germany's education sector}, number = {157}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-561-3}, issn = {1613-5652}, doi = {10.25932/publishup-59772}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-597723}, publisher = {Universit{\"a}t Potsdam}, pages = {1 -- 27}, year = {2023}, abstract = {Digital technology offers significant political, economic, and societal opportunities. At the same time, the notion of digital sovereignty has become a leitmotif in German discourse: the state's capacity to assume its responsibilities and safeguard society's - and individuals' - ability to shape the digital transformation in a self-determined way. The education sector is exemplary for the challenge faced by Germany, and indeed Europe, of harnessing the benefits of digital technology while navigating concerns around sovereignty. It encompasses education as a core public good, a rapidly growing field of business, and growing pools of highly sensitive personal data. The report describes pathways to mitigating the tension between digitalization and sovereignty at three different levels - state, economy, and individual - through the lens of concrete technical projects in the education sector: the HPI Schul-Cloud (state sovereignty), the MERLOT data spaces (economic sovereignty), and the openHPI platform (individual sovereignty).}, language = {en} } @book{MeinelGalbasHageboelling2023, author = {Meinel, Christoph and Galbas, Michael and Hageb{\"o}lling, David}, title = {Digitale Souver{\"a}nit{\"a}t: Erkenntnisse aus dem deutschen Bildungssektor}, number = {156}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-560-6}, issn = {1613-5652}, doi = {10.25932/publishup-59513}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-595138}, publisher = {Universit{\"a}t Potsdam}, pages = {1 -- 29}, year = {2023}, abstract = {Digitale Technologien bieten erhebliche politische, wirtschaftliche und gesellschaftliche Chancen. Zugleich ist der Begriff digitale Souver{\"a}nit{\"a}t zu einem Leitmotiv im deutschen Diskurs {\"u}ber digitale Technologien geworden: das heißt, die F{\"a}higkeit des Staates, seine Verantwortung wahrzunehmen und die Bef{\"a}higung der Gesellschaft - und des Einzelnen - sicherzustellen, die digitale Transformation selbstbestimmt zu gestalten. Exemplarisch f{\"u}r die Herausforderung in Deutschland und Europa, die Vorteile digitaler Technologien zu nutzen und gleichzeitig Souver{\"a}nit{\"a}tsbedenken zu ber{\"u}cksichtigen, steht der Bildungssektor. Er umfasst Bildung als zentrales {\"o}ffentliches Gut, ein schnell aufkommendes Gesch{\"a}ftsfeld und wachsende Best{\"a}nde an hochsensiblen personenbezogenen Daten. Davon ausgehend beschreibt der Bericht Wege zur Entsch{\"a}rfung des Spannungsverh{\"a}ltnisses zwischen Digitalisierung und Souver{\"a}nit{\"a}t auf drei verschiedenen Ebenen - Staat, Wirtschaft und Individuum - anhand konkreter technischer Projekte im Bildungsbereich: die HPI Schul-Cloud (staatliche Souver{\"a}nit{\"a}t), die MERLOT-Datenr{\"a}ume (wirtschaftliche Souver{\"a}nit{\"a}t) und die openHPI-Plattform (individuelle Souver{\"a}nit{\"a}t).}, language = {de} } @article{LewkowiczBoettingerSiegel2023, author = {Lewkowicz, Daniel and B{\"o}ttinger, Erwin and Siegel, Martin}, title = {Economic evaluation of digital therapeutic care apps for unsupervised treatment of low back pain}, series = {JMIR mhealth and uhealth}, volume = {11}, journal = {JMIR mhealth and uhealth}, publisher = {JMIR Publications}, address = {Toronto}, issn = {2291-5222}, doi = {10.2196/44585}, pages = {14}, year = {2023}, abstract = {Background: Digital therapeutic care (DTC) programs are unsupervised app-based treatments that provide video exercises and educational material to patients with nonspecific low back pain during episodes of pain and functional disability. German statutory health insurance can reimburse DTC programs since 2019, but evidence on efficacy and reasonable pricing remains scarce. This paper presents a probabilistic sensitivity analysis (PSA) to evaluate the efficacy and cost-utility of a DTC app against treatment as usual (TAU) in Germany. Objective: The aim of this study was to perform a PSA in the form of a Monte Carlo simulation based on the deterministic base case analysis to account for model assumptions and parameter uncertainty. We also intend to explore to what extent the results in this probabilistic analysis differ from the results in the base case analysis and to what extent a shortage of outcome data concerning quality-of-life (QoL) metrics impacts the overall results. Methods: The PSA builds upon a state-transition Markov chain with a 4-week cycle length over a model time horizon of 3 years from a recently published deterministic cost-utility analysis. A Monte Carlo simulation with 10,000 iterations and a cohort size of 10,000 was employed to evaluate the cost-utility from a societal perspective. Quality-adjusted life years (QALYs) were derived from Veterans RAND 6-Dimension (VR-6D) and Short-Form 6-Dimension (SF-6D) single utility scores. Finally, we also simulated reducing the price for a 3-month app prescription to analyze at which price threshold DTC would result in being the dominant strategy over TAU in Germany. Results: The Monte Carlo simulation yielded on average a euro135.97 (a currency exchange rate of EUR euro1=US \$1.069 is applicable) incremental cost and 0.004 incremental QALYs per person and year for the unsupervised DTC app strategy compared to in-person physiotherapy in Germany. The corresponding incremental cost-utility ratio (ICUR) amounts to an additional euro34,315.19 per additional QALY. DTC yielded more QALYs in 54.96\% of the iterations. DTC dominates TAU in 24.04\% of the iterations for QALYs. Reducing the app price in the simulation from currently euro239.96 to euro164.61 for a 3-month prescription could yield a negative ICUR and thus make DTC the dominant strategy, even though the estimated probability of DTC being more effective than TAU is only 54.96\%. Conclusions: Decision-makers should be cautious when considering the reimbursement of DTC apps since no significant treatment effect was found, and the probability of cost-effectiveness remains below 60\% even for an infinite willingness-to-pay threshold. More app-based studies involving the utilization of QoL outcome parameters are urgently needed to account for the low and limited precision of the available QoL input parameters, which are crucial to making profound recommendations concerning the cost-utility of novel apps.}, language = {en} } @article{LewkowiczWohlbrandtBoettinger2020, author = {Lewkowicz, Daniel and Wohlbrandt, Attila and B{\"o}ttinger, Erwin}, title = {Economic impact of clinical decision support interventions based on electronic health records}, series = {BMC Health Services Research}, volume = {20}, journal = {BMC Health Services Research}, publisher = {BioMed Central}, address = {London}, issn = {1472-6963}, doi = {10.1186/s12913-020-05688-3}, pages = {12}, year = {2020}, abstract = {Background Unnecessary healthcare utilization, non-adherence to current clinical guidelines, or insufficient personalized care are perpetual challenges and remain potential major cost-drivers for healthcare systems around the world. Implementing decision support systems into clinical care is promised to improve quality of care and thereby yield substantial effects on reducing healthcare expenditure. In this article, we evaluate the economic impact of clinical decision support (CDS) interventions based on electronic health records (EHR). Methods We searched for studies published after 2014 using MEDLINE, CENTRAL, WEB OF SCIENCE, EBSCO, and TUFTS CEA registry databases that encompass an economic evaluation or consider cost outcome measures of EHR based CDS interventions. Thereupon, we identified best practice application areas and categorized the investigated interventions according to an existing taxonomy of front-end CDS tools. Results and discussion Twenty-seven studies are investigated in this review. Of those, twenty-two studies indicate a reduction of healthcare expenditure after implementing an EHR based CDS system, especially towards prevalent application areas, such as unnecessary laboratory testing, duplicate order entry, efficient transfusion practice, or reduction of antibiotic prescriptions. On the contrary, order facilitators and undiscovered malfunctions revealed to be threats and could lead to new cost drivers in healthcare. While high upfront and maintenance costs of CDS systems are a worldwide implementation barrier, most studies do not consider implementation cost. Finally, four included economic evaluation studies report mixed monetary outcome results and thus highlight the importance of further high-quality economic evaluations for these CDS systems. Conclusion Current research studies lack consideration of comparative cost-outcome metrics as well as detailed cost components in their analyses. Nonetheless, the positive economic impact of EHR based CDS interventions is highly promising, especially with regard to reducing waste in healthcare.}, language = {en} } @inproceedings{JacqminOezdemirFellKurbanetal.2021, author = {Jacqmin, Julien and {\"O}zdemir, Paker Doğu and Fell Kurban, Caroline and Tun{\c{c}} Pekkan, Zelha and Koskinen, Johanna and Suonp{\"a}{\"a}, Maija and Seng, Cheyvuth and Carlon, May Kristine Jonson and Gayed, John Maurice and Cross, Jeffrey S. and Langseth, Inger and Jacobsen, Dan Yngve and Haugsbakken, Halvdan and Bethge, Joseph and Serth, Sebastian and Staubitz, Thomas and Wuttke, Tobias and Nordemann, Oliver and Das, Partha-Pratim and Meinel, Christoph and Ponce, Eva and Srinath, Sindhu and Allegue, Laura and Perach, Shai and Alexandron, Giora and Corti, Paola and Baudo, Valeria and Turr{\´o}, Carlos and Moura Santos, Ana and Nilsson, Charlotta and Maldonado-Mahauad, Jorge and Valdiviezo, Javier and Carvallo, Juan Pablo and Samaniego-Erazo, Nicolay and Poce, Antonella and Re, Maria Rosaria and Valente, Mara and Karp Gershon, Sa'ar and Ruip{\´e}rez-Valiente, Jos{\´e} A. and Despujol, Ignacio and Busquets, Jaime and Kerr, John and Lorenz, Anja and Sch{\"o}n, Sandra and Ebner, Martin and Wittke, Andreas and Beirne, Elaine and Nic Giolla Mhich{\´i}l, Mair{\´e}ad and Brown, Mark and Mac Lochlainn, Conch{\´u}r and Topali, Paraskevi and Chounta, Irene-Angelica and Ortega-Arranz, Alejandro and Villagr{\´a}-Sobrino, Sara L. and Mart{\´i}nez-Mon{\´e}s, Alejandra and Blackwell, Virginia Katherine and Wiltrout, Mary Ellen and Rami Gaddem, Mohamed and Hern{\´a}ndez Reyes, C{\´e}sar Augusto and Nagahama, Toru and Buchem, Ilona and Okatan, Ebru and Khalil, Mohammad and Casiraghi, Daniela and Sancassani, Susanna and Brambilla, Federica and Mihaescu, Vlad and Andone, Diana and Vasiu, Radu and Şahin, Muhittin and Egloffstein, Marc and Bothe, Max and Rohloff, Tobias and Schenk, Nathanael and Schwerer, Florian and Ifenthaler, Dirk and Hense, Julia and Bernd, Mike}, title = {EMOOCs 2021}, editor = {Meinel, Christoph and Staubitz, Thomas and Schweiger, Stefanie and Friedl, Christian and Kiers, Janine and Ebner, Martin and Lorenz, Anja and Ubachs, George and Mongenet, Catherine and Ruip{\´e}rez-Valiente, Jos{\´e} A. and Cortes Mendez, Manoel}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51030}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-510300}, pages = {vii, 295}, year = {2021}, abstract = {From June 22 to June 24, 2021, Hasso Plattner Institute, Potsdam, hosted the seventh European MOOC Stakeholder Summit (EMOOCs 2021) together with the eighth ACM Learning@Scale Conference. Due to the COVID-19 situation, the conference was held fully online. The boost in digital education worldwide as a result of the pandemic was also one of the main topics of this year's EMOOCs. All institutions of learning have been forced to transform and redesign their educational methods, moving from traditional models to hybrid or completely online models at scale. The learnings, derived from practical experience and research, have been explored in EMOOCs 2021 in six tracks and additional workshops, covering various aspects of this field. In this publication, we present papers from the conference's Experience Track, the Policy Track, the Business Track, the International Track, and the Workshops.}, language = {en} } @inproceedings{EsveldVriesBecchettietal.2023, author = {Esveld, Selma van and Vries, Nardo de and Becchetti, Sibilla and Dopper, Sofia and Valkenburg, Willem van and Carlon, May Kristine Jonson and Yokoi, Kensuke and Gayed, John Maurice and Suyama, Hiroshi and Cross, Jeffrey Scott and Jin, Tonje and Xue, Wei and Bruillard, {\´E}ric and Steinbeck, Hendrik and Meinel, Christoph and {\"O}zdemir, Paker Doğu and Can Bayer, Burak and Mercan, Duygu and Buyurucu, Gamze and Haugsbakken, Halvdan and Hagelia, Marianne and Ebner, Martin and Edelsbrunner, Sarah and Hohla-Sejkora, Katharina and Lipp, Silvia and Sch{\"o}n, Sandra and Xiaoxiao, Wang and Shuangshuang, Guo and Morales-Chan, Miguel and Amado-Salvatierra, H{\´e}ctor R. and Hern{\´a}ndez-Rizzardini, Rocael and Egloffstein, Marc and H{\"u}nemohr, Holger and Ifenthaler, Dirk and Dixon, Fred and Trabucchi, Stefania and Khaneboubi, Mehdi and Giannatelli, Ada and Tomasini, Alessandra and Staubitz, Thomas and Serth, Sebastian and Thomas, Max and Koschutnig-Ebner, Markus and Rampelt, Florian and Stetten, Alexander von and Wittke, Andreas and Theeraroungchaisri, Anuchai and Thammetar, Thapanee and Duangchinda, Vorasuang and Khlaisang, Jintavee and Mair, Bettina and Steinkellner, Iris and Stojcevic, Ivana and Zwiauer, Charlotte and Thirouard, Maria and Vill{\`e}sbrunne, Marie de la and Bernaert, Oliver and Nohr, Magnus and Alario Hoyos, Carlos and Delgado Kloos, Carlos and Kiendl, Doris and Terzieva, Liliya and Concia, Francesca and Distler, Petr and Law, Gareth and Macerata, Elena and Mariani, Mario and Mossini, Eros and Negrin, Maddalena and Štrok, Marko and Neub{\"o}ck, Kristina and Linschinger, Nadine and Lorenz, Anja and Bock, Stefanie and Schulte-Ostermann, Juleka and Moura Santos, Ana and Corti, Paola and Costa, Luis Felipe Coimbra and Utunen, Heini and Attias, Melissa and Tokar, Anna and Kennedy, Eileen and Laurillard, Diana and Zeitoun, Samar and Wasilewski, Julie and Shlaka, Souhad and Ouahib, Sara and Berrada, Khalid and Dietz, Michael and Roth, Dennis}, title = {EMOOCs 2023}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Cross, Jeffrey and Jonson Carlon, May Kristine and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, doi = {10.25932/publishup-57645}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-576450}, year = {2023}, abstract = {From June 14 to June 16, 2023, Hasso Plattner Institute, Potsdam, hosted the eighth European MOOC Stakeholder Summit (EMOOCs 2023). The pandemic is fortunately over. It has once again shown how important digital education is. How well-prepared a country was could be seen in our schools, universities, and companies. In different countries, the problems manifested themselves differently. The measures and approaches to solving the problems varied accordingly. Digital education, whether micro-credentials, MOOCs, blended learning formats, or other e-learning tools, received a major boost. EMOOCs 2023 focusses on the effects of this emergency situation. How has it affected the development and delivery of MOOCs and other e-learning offerings all over Europe? Which projects can serve as models for successful digital learning and teaching? Which roles can MOOCs and micro-credentials bear in the current business transformation? Is there a backlash to the routine we knew from pre-Corona times? Or have many things become firmly established in the meantime, e.g. remote work, hybrid conferences, etc.? Furthermore, EMOOCs 2023 has a closer look at the development and formalization of digital learning. Micro-credentials are just the starting point. Further steps in this direction would be complete online study programs or full online universities. Another main topic is the networking of learning offers and the standardization of formats and metadata. Examples of fruitful cooperations are the MOOChub, the European MOOC Consortium, and the Common Micro-Credential Framework. The learnings, derived from practical experience and research, are explored in EMOOCs 2023 in four tracks and additional workshops, covering various aspects of this field. In this publication, we present papers from the conference's Research \& Experience Track, the Business Track and the International Track.}, language = {en} } @article{PoceReValente2021, author = {Poce, Antonella and Re, Maria Rosaria and Valente, Mara}, title = {Evaluating OERs in Museum Education Context}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51717}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517178}, pages = {159 -- 168}, year = {2021}, abstract = {This paper aims to present the results of a higher education experience promoted by the research centres INTELLECT (University of Modena and Reggio Emilia) and CDM (University of Roma Tre), as part of difference master's degrees programme of the academic years 2018/2019, 2019/2020, and 2020/2021. Through different online activities, 37 students attended and evaluated a MOOC on museum education content, such promoting their professionals and transverse skills, such as critical thinking, and developing their knowledge relative to OERs, within culture and heritage education contexts. Moreover, results from the online evaluation activities support the implementation of the MOOC in a collaborative way: during the academic years, evaluation data have been used by researcher to make changes to the course modules, thus realizing a more effective online path from and educational point of view.}, language = {en} } @article{AlbertOwolabiGebeletal.2020, author = {Albert, Justin Amadeus and Owolabi, Victor and Gebel, Arnd and Brahms, Clemens Markus and Granacher, Urs and Arnrich, Bert}, title = {Evaluation of the Pose Tracking Performance of the Azure Kinect and Kinect v2 for Gait Analysis in Comparison with a Gold Standard}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {18}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20185104}, pages = {22}, year = {2020}, abstract = {Gait analysis is an important tool for the early detection of neurological diseases and for the assessment of risk of falling in elderly people. The availability of low-cost camera hardware on the market today and recent advances in Machine Learning enable a wide range of clinical and health-related applications, such as patient monitoring or exercise recognition at home. In this study, we evaluated the motion tracking performance of the latest generation of the Microsoft Kinect camera, Azure Kinect, compared to its predecessor Kinect v2 in terms of treadmill walking using a gold standard Vicon multi-camera motion capturing system and the 39 marker Plug-in Gait model. Five young and healthy subjects walked on a treadmill at three different velocities while data were recorded simultaneously with all three camera systems. An easy-to-administer camera calibration method developed here was used to spatially align the 3D skeleton data from both Kinect cameras and the Vicon system. With this calibration, the spatial agreement of joint positions between the two Kinect cameras and the reference system was evaluated. In addition, we compared the accuracy of certain spatio-temporal gait parameters, i.e., step length, step time, step width, and stride time calculated from the Kinect data, with the gold standard system. Our results showed that the improved hardware and the motion tracking algorithm of the Azure Kinect camera led to a significantly higher accuracy of the spatial gait parameters than the predecessor Kinect v2, while no significant differences were found between the temporal parameters. Furthermore, we explain in detail how this experimental setup could be used to continuously monitor the progress during gait rehabilitation in older people.}, language = {en} } @article{EhrigWagnerWolteretal.2023, author = {Ehrig, Lukas and Wagner, Ann-Christin and Wolter, Heike and Correll, Christoph U. and Geisel, Olga and Konigorski, Stefan}, title = {FASDetect as a machine learning-based screening app for FASD in youth with ADHD}, series = {npj Digital Medicine}, volume = {6}, journal = {npj Digital Medicine}, number = {1}, publisher = {Macmillan Publishers Limited}, address = {Basingstoke}, issn = {2398-6352}, doi = {10.1038/s41746-023-00864-1}, pages = {9}, year = {2023}, abstract = {Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a German University outpatient unit are assessed including 275 patients aged 0-19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0-19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance. Random forest models yield the best prediction models with a cross-validated AUC of 0.92 (95\% confidence interval [0.84, 0.99]). Follow-up analyses indicate that a random forest model with 6 variables - body length and head circumference at birth, IQ, socially intrusive behaviour, poor memory and sleep disturbance - yields equivalent predictive accuracy. We implement the prediction model in a web-based app called FASDetect - a user-friendly, clinically scalable FASD risk calculator that is freely available at https://fasdetect.dhc-lab.hpi.de.}, language = {en} } @book{EichenrothReinHirschfeld2022, author = {Eichenroth, Friedrich and Rein, Patrick and Hirschfeld, Robert}, title = {Fast packrat parsing in a live programming environment}, series = {Technische Berichte des Hasso-Plattner-Instituts f{\"u}r Digital Engineering an der Universit{\"a}t Potsdam}, journal = {Technische Berichte des Hasso-Plattner-Instituts f{\"u}r Digital Engineering an der Universit{\"a}t Potsdam}, number = {135}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-503-3}, issn = {1613-5652}, doi = {10.25932/publishup-49124}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-491242}, publisher = {Universit{\"a}t Potsdam}, pages = {79}, year = {2022}, abstract = {Language developers who design domain-specific languages or new language features need a way to make fast changes to language definitions. Those fast changes require immediate feedback. Also, it should be possible to parse the developed languages quickly to handle extensive sets of code. Parsing expression grammars provides an easy to understand method for language definitions. Packrat parsing is a method to parse grammars of this kind, but this method is unable to handle left-recursion properly. Existing solutions either partially rewrite left-recursive rules and partly forbid them, or use complex extensions to packrat parsing that are hard to understand and cost-intensive. We investigated methods to make parsing as fast as possible, using easy to follow algorithms while not losing the ability to make fast changes to grammars. We focused our efforts on two approaches. One is to start from an existing technique for limited left-recursion rewriting and enhance it to work for general left-recursive grammars. The second approach is to design a grammar compilation process to find left-recursion before parsing, and in this way, reduce computational costs wherever possible and generate ready to use parser classes. Rewriting parsing expression grammars is a task that, if done in a general way, unveils a large number of cases such that any rewriting algorithm surpasses the complexity of other left-recursive parsing algorithms. Lookahead operators introduce this complexity. However, most languages have only little portions that are left-recursive and in virtually all cases, have no indirect or hidden left-recursion. This means that the distinction of left-recursive parts of grammars from components that are non-left-recursive holds great improvement potential for existing parsers. In this report, we list all the required steps for grammar rewriting to handle left-recursion, including grammar analysis, grammar rewriting itself, and syntax tree restructuring. Also, we describe the implementation of a parsing expression grammar framework in Squeak/Smalltalk and the possible interactions with the already existing parser Ohm/S. We quantitatively benchmarked this framework directing our focus on parsing time and the ability to use it in a live programming context. Compared with Ohm, we achieved massive parsing time improvements while preserving the ability to use our parser it as a live programming tool. The work is essential because, for one, we outlined the difficulties and complexity that come with grammar rewriting. Also, we removed the existing limitations that came with left-recursion by eliminating them before parsing.}, language = {en} } @article{KappattanavarHeckerMoontahaetal.2023, author = {Kappattanavar, Arpita Mallikarjuna and Hecker, Pascal and Moontaha, Sidratul and Steckhan, Nico and Arnrich, Bert}, title = {Food choices after cognitive load}, series = {Sensors}, volume = {23}, journal = {Sensors}, number = {14}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s23146597}, pages = {22}, year = {2023}, abstract = {Psychology and nutritional science research has highlighted the impact of negative emotions and cognitive load on calorie consumption behaviour using subjective questionnaires. Isolated studies in other domains objectively assess cognitive load without considering its effects on eating behaviour. This study aims to explore the potential for developing an integrated eating behaviour assistant system that incorporates cognitive load factors. Two experimental sessions were conducted using custom-developed experimentation software to induce different stimuli. During these sessions, we collected 30 h of physiological, food consumption, and affective states questionnaires data to automatically detect cognitive load and analyse its effect on food choice. Utilising grid search optimisation and leave-one-subject-out cross-validation, a support vector machine model achieved a mean classification accuracy of 85.12\% for the two cognitive load tasks using eight relevant features. Statistical analysis was performed on calorie consumption and questionnaire data. Furthermore, 75\% of the subjects with higher negative affect significantly increased consumption of specific foods after high-cognitive-load tasks. These findings offer insights into the intricate relationship between cognitive load, affective states, and food choice, paving the way for an eating behaviour assistant system to manage food choices during cognitive load. Future research should enhance system capabilities and explore real-world applications.}, language = {en} } @article{CortiBaudoTurroetal.2021, author = {Corti, Paola and Baudo, Valeria and Turr{\´o}, Carlos and Santos, Ana Moura and Nilsson, Charlotta}, title = {Fostering Women to STEM MOOCs}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51714}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517141}, pages = {129 -- 141}, year = {2021}, abstract = {In the context of the Fostering Women to STEM MOOCs (FOSTWOM) project, we present here the general ideas of a gender balance Toolkit, i.e. a collection of recommendations and resources for instructional designers, visual designers, and teaching staff to apply while designing and preparing storyboards for MOOCs and their visual components, so that future STEM online courses have a greater chance to be more inclusive and gender-balanced. Overall, The FOSTWOM project intends to use the inclusive potential of Massive Open Online Courses to propose STEM subjects free of stereotyping assumptions on gender abilities. Moreover, the consortium is interested in attracting girls and young women to science and technology careers, through accessible online content, which can include role models' interviews, relevant real-world situations, and strong conceptual frameworks.}, language = {en} } @article{ThirouarddelaVillesbrunneBernaert2023, author = {Thirouard, Maria and de la Vill{\`e}sbrunne, Marie and Bernaert, Oliver}, title = {From MOOC to "2M-POC"}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62426}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624268}, pages = {187 -- 200}, year = {2023}, abstract = {IFP School develops and produces MOOCs since 2014. After the COVID-19 crisis, the demand of our industrial and international partners to offer continuous training to their employees increased drastically in an energy transition and sustainable mobility environment that finds itself in constant and rapid evolution. Therefore, it is time for a new format of digital learning tools to efficiently and rapidly train an important number of employees. To address this new demand, in a more and more digital learning environment, we have completely changed our initial MOOC model to propose an innovative SPOC business model mixing synchronous and asynchronous modules. This paper describes the work that has been done to transform our MOOCs to a hybrid SPOC model. We changed the format itself from a standard MOOC model of several weeks to small modules of one week average more adapted to our client's demand. We precisely engineered the exchanges between learners and the social aspect all along the SPOC duration. We propose a multimodal approach with a combination of asynchronous activities like online module, exercises, and synchronous activities like webinars with experts, and after-work sessions. Additionally, this new format increases the number of uses of the MOOC resources by our professors in our own master programs. With all these actions, we were able to reach a completion rate between 80 and 96\% - total enrolled -, compared to the completion rate of 15 to 28\% - total enrolled - as to be recorded in our original MOOC format. This is to be observed for small groups (50-100 learners) as SPOC but also for large groups (more than 2500 learners), as a Massive and Multimodal Private Online Course ("2M-POC"). Today a MOOC is not a simple assembly of videos, text, discussions forums and validation exercises but a complete multimodal learning path including social learning, personal followup, synchronous and asynchronous modules. We conclude that the original MOOC format is not at all suitable to propose efficient training to companies, and we must re-engineer the learning path to have a SPOC hybrid and multimodal training compatible with a cost-effective business model.}, language = {en} } @article{EssenSternHaaseetal.2022, author = {Essen, Anna and Stern, Ariel Dora and Haase, Christoffer Bjerre and Car, Josip and Greaves, Felix and Paparova, Dragana and Vandeput, Steven and Wehrens, Rik and Bates, David W.}, title = {Health app policy}, series = {npj digital medicine}, volume = {5}, journal = {npj digital medicine}, number = {1}, publisher = {Macmillan Publishers Limited}, address = {Basingstoke}, issn = {2398-6352}, doi = {10.1038/s41746-022-00573-1}, pages = {10}, year = {2022}, abstract = {An abundant and growing supply of digital health applications (apps) exists in the commercial tech-sector, which can be bewildering for clinicians, patients, and payers. A growing challenge for the health care system is therefore to facilitate the identification of safe and effective apps for health care practitioners and patients to generate the most health benefit as well as guide payer coverage decisions. Nearly all developed countries are attempting to define policy frameworks to improve decision-making, patient care, and health outcomes in this context. This study compares the national policy approaches currently in development/use for health apps in nine countries. We used secondary data, combined with a detailed review of policy and regulatory documents, and interviews with key individuals and experts in the field of digital health policy to collect data about implemented and planned policies and initiatives. We found that most approaches aim for centralized pipelines for health app approvals, although some countries are adding decentralized elements. While the countries studied are taking diverse paths, there is nevertheless broad, international convergence in terms of requirements in the areas of transparency, health content, interoperability, and privacy and security. The sheer number of apps on the market in most countries represents a challenge for clinicians and patients. Our analyses of the relevant policies identified challenges in areas such as reimbursement, safety, and privacy and suggest that more regulatory work is needed in the areas of operationalization, implementation and international transferability of approvals. Cross-national efforts are needed around regulation and for countries to realize the benefits of these technologies.}, language = {en} } @article{WasilewskiKhaneboubiBruillard2023, author = {Wasilewski, Julie and Khaneboubi, Mehdi and Bruillard, {\´E}ric}, title = {How to detect At-Risk learners in professional finance MOOCs}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62481}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624818}, pages = {305 -- 316}, year = {2023}, abstract = {"Financial Analysis" is an online course designed for professionals consisting of three MOOCs, offering a professionally and institutionally recognized certificate in finance. The course is open but not free of charge and attracts mostly professionals from the banking industry. The primary objective of this study is to identify indicators that can predict learners at high risk of failure. To achieve this, we analyzed data from a previous course that had 875 enrolled learners and involve in the course during Fall 2021. We utilized correspondence analysis to examine demographic and behavioral variables. The initial results indicate that demographic factors have a minor impact on the risk of failure in comparison to learners' behaviors on the course platform. Two primary profiles were identified: (1) successful learners who utilized all the documents offered and spent between one to two hours per week, and (2) unsuccessful learners who used less than half of the proposed documents and spent less than one hour per week. Between these groups, at-risk students were identified as those who used more than half of the proposed documents and spent more than two hours per week. The goal is to identify those in group 1 who may be at risk of failing and those in group 2 who may succeed in the current MOOC, and to implement strategies to assist all learners in achieving success.}, language = {en} } @article{MouraSantosCortiFelipeCoimbraCosta2023, author = {Moura Santos, Ana and Corti, Paola and Felipe Coimbra Costa, Luis}, title = {How to reuse inclusive stem Moocs in blended settings to engage young girls to scientific careers}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62475}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624756}, pages = {271 -- 278}, year = {2023}, abstract = {The FOSTWOM project (2019-2022), an ERASMUS+ funding, gave METID (Politecnico di Milano) and the MOOC T{\´e}cnico (Instituto Superior T{\´e}cnico, University of Lisbon), together with other partners, the opportunity to support the design and creation of gender-inclusive MOOCs. Among other project outputs, we designed a toolkit and a framework that enabled the production of two MOOCs for undergraduate and graduate students in Science, Technology, Engineering and Maths (STEM) and used them as academic content free of gender stereotypes about intellectual ability. In this short paper, the authors aim to 1) briefly share the main outputs of the project; 2) tell the story of how the FOSTWOM approach together with 3) a motivational strategy, the Heroine's Learning Journey, proved to be effective in the context of rural and marginal areas in Brazil, with young girls as a specific target audience.}, language = {en} } @article{ZhouFischerTuncaetal.2020, author = {Zhou, Lin and Fischer, Eric and Tunca, Can and Brahms, Clemens Markus and Ersoy, Cem and Granacher, Urs and Arnrich, Bert}, title = {How We Found Our IMU}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {15}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20154090}, pages = {29}, year = {2020}, abstract = {Inertial measurement units (IMUs) are commonly used for localization or movement tracking in pervasive healthcare-related studies, and gait analysis is one of the most often studied topics using IMUs. The increasing variety of commercially available IMU devices offers convenience by combining the sensor modalities and simplifies the data collection procedures. However, selecting the most suitable IMU device for a certain use case is increasingly challenging. In this study, guidelines for IMU selection are proposed. In particular, seven IMUs were compared in terms of their specifications, data collection procedures, and raw data quality. Data collected from the IMUs were then analyzed by a gait analysis algorithm. The difference in accuracy of the calculated gait parameters between the IMUs could be used to retrace the issues in raw data, such as acceleration range or sensor calibration. Based on our algorithm, we were able to identify the best-suited IMUs for our needs. This study provides an overview of how to select the IMUs based on the area of study with concrete examples, and gives insights into the features of seven commercial IMUs using real data.}, language = {en} } @book{RanaMohapatraSidorovaetal.2022, author = {Rana, Kaushik and Mohapatra, Durga Prasad and Sidorova, Julia and Lundberg, Lars and Sk{\"o}ld, Lars and Lopes Grim, Lu{\´i}s Fernando and Sampaio Gradvohl, Andr{\´e} Leon and Cremerius, Jonas and Siegert, Simon and Weltzien, Anton von and Baldi, Annika and Klessascheck, Finn and Kalancha, Svitlana and Lichtenstein, Tom and Shaabani, Nuhad and Meinel, Christoph and Friedrich, Tobias and Lenzner, Pascal and Schumann, David and Wiese, Ingmar and Sarna, Nicole and Wiese, Lena and Tashkandi, Araek Sami and van der Walt, Est{\´e}e and Eloff, Jan H. P. and Schmidt, Christopher and H{\"u}gle, Johannes and Horschig, Siegfried and Uflacker, Matthias and Najafi, Pejman and Sapegin, Andrey and Cheng, Feng and Stojanovic, Dragan and Stojnev Ilić, Aleksandra and Djordjevic, Igor and Stojanovic, Natalija and Predic, Bratislav and Gonz{\´a}lez-Jim{\´e}nez, Mario and de Lara, Juan and Mischkewitz, Sven and Kainz, Bernhard and van Hoorn, Andr{\´e} and Ferme, Vincenzo and Schulz, Henning and Knigge, Marlene and Hecht, Sonja and Prifti, Loina and Krcmar, Helmut and Fabian, Benjamin and Ermakova, Tatiana and Kelkel, Stefan and Baumann, Annika and Morgenstern, Laura and Plauth, Max and Eberhard, Felix and Wolff, Felix and Polze, Andreas and Cech, Tim and Danz, Noel and Noack, Nele Sina and Pirl, Lukas and Beilharz, Jossekin Jakob and De Oliveira, Roberto C. L. and Soares, F{\´a}bio Mendes and Juiz, Carlos and Bermejo, Belen and M{\"u}hle, Alexander and Gr{\"u}ner, Andreas and Saxena, Vageesh and Gayvoronskaya, Tatiana and Weyand, Christopher and Krause, Mirko and Frank, Markus and Bischoff, Sebastian and Behrens, Freya and R{\"u}ckin, Julius and Ziegler, Adrian and Vogel, Thomas and Tran, Chinh and Moser, Irene and Grunske, Lars and Sz{\´a}rnyas, G{\´a}bor and Marton, J{\´o}zsef and Maginecz, J{\´a}nos and Varr{\´o}, D{\´a}niel and Antal, J{\´a}nos Benjamin}, title = {HPI Future SOC Lab - Proceedings 2018}, number = {151}, editor = {Meinel, Christoph and Polze, Andreas and Beins, Karsten and Strotmann, Rolf and Seibold, Ulrich and R{\"o}dszus, Kurt and M{\"u}ller, J{\"u}rgen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-547-7}, issn = {1613-5652}, doi = {10.25932/publishup-56371}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-563712}, publisher = {Universit{\"a}t Potsdam}, pages = {x, 277}, year = {2022}, abstract = {The "HPI Future SOC Lab" is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2018. Selected projects have presented their results on April 17th and November 14th 2017 at the Future SOC Lab Day events.}, language = {en} } @book{KubanRottaNolteetal.2024, author = {Kuban, Robert and Rotta, Randolf and Nolte, J{\"o}rg and Chromik, Jonas and Beilharz, Jossekin Jakob and Pirl, Lukas and Friedrich, Tobias and Lenzner, Pascal and Weyand, Christopher and Juiz, Carlos and Bermejo, Belen and Sauer, Joao and Coelh, Leandro dos Santos and Najafi, Pejman and P{\"u}nter, Wenzel and Cheng, Feng and Meinel, Christoph and Sidorova, Julia and Lundberg, Lars and Vogel, Thomas and Tran, Chinh and Moser, Irene and Grunske, Lars and Elsaid, Mohamed Esameldin Mohamed and Abbas, Hazem M. and Rula, Anisa and Sejdiu, Gezim and Maurino, Andrea and Schmidt, Christopher and H{\"u}gle, Johannes and Uflacker, Matthias and Nozza, Debora and Messina, Enza and Hoorn, Andr{\´e} van and Frank, Markus and Schulz, Henning and Alhosseini Almodarresi Yasin, Seyed Ali and Nowicki, Marek and Muite, Benson K. and Boysan, Mehmet Can and Bianchi, Federico and Cremaschi, Marco and Moussa, Rim and Abdel-Karim, Benjamin M. and Pfeuffer, Nicolas and Hinz, Oliver and Plauth, Max and Polze, Andreas and Huo, Da and Melo, Gerard de and Mendes Soares, F{\´a}bio and Oliveira, Roberto C{\´e}lio Lim{\~a}o de and Benson, Lawrence and Paul, Fabian and Werling, Christian and Windheuser, Fabian and Stojanovic, Dragan and Djordjevic, Igor and Stojanovic, Natalija and Stojnev Ilic, Aleksandra and Weidmann, Vera and Lowitzki, Leon and Wagner, Markus and Ifa, Abdessatar Ben and Arlos, Patrik and Megia, Ana and Vendrell, Joan and Pfitzner, Bjarne and Redondo, Alberto and R{\´i}os Insua, David and Albert, Justin Amadeus and Zhou, Lin and Arnrich, Bert and Szab{\´o}, Ildik{\´o} and Fodor, Szabina and Ternai, Katalin and Bhowmik, Rajarshi and Campero Durand, Gabriel and Shevchenko, Pavlo and Malysheva, Milena and Prymak, Ivan and Saake, Gunter}, title = {HPI Future SOC Lab - Proceedings 2019}, number = {158}, editor = {Meinel, Christoph and Polze, Andreas and Beins, Karsten and Strotmann, Rolf and Seibold, Ulrich and R{\"o}dszus, Kurt and M{\"u}ller, J{\"u}rgen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-564-4}, issn = {1613-5652}, doi = {10.25932/publishup-59791}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-597915}, publisher = {Universit{\"a}t Potsdam}, pages = {xi, 301}, year = {2024}, abstract = {The "HPI Future SOC Lab" is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2019. Selected projects have presented their results on April 9th and November 12th 2019 at the Future SOC Lab Day events.}, language = {en} } @book{Weber2023, author = {Weber, Benedikt}, title = {Human pose estimation for decubitus prophylaxis}, number = {153}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-551-4}, issn = {1613-5652}, doi = {10.25932/publishup-56719}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-567196}, publisher = {Universit{\"a}t Potsdam}, pages = {73}, year = {2023}, abstract = {Decubitus is one of the most relevant diseases in nursing and the most expensive to treat. It is caused by sustained pressure on tissue, so it particularly affects bed-bound patients. This work lays a foundation for pressure mattress-based decubitus prophylaxis by implementing a solution to the single-frame 2D Human Pose Estimation problem. For this, methods of Deep Learning are employed. Two approaches are examined, a coarse-to-fine Convolutional Neural Network for direct regression of joint coordinates and a U-Net for the derivation of probability distribution heatmaps. We conclude that training our models on a combined dataset of the publicly available Bodies at Rest and SLP data yields the best results. Furthermore, various preprocessing techniques are investigated, and a hyperparameter optimization is performed to discover an improved model architecture. Another finding indicates that the heatmap-based approach outperforms direct regression. This model achieves a mean per-joint position error of 9.11 cm for the Bodies at Rest data and 7.43 cm for the SLP data. We find that it generalizes well on data from mattresses other than those seen during training but has difficulties detecting the arms correctly. Additionally, we give a brief overview of the medical data annotation tool annoto we developed in the bachelor project and furthermore conclude that the Scrum framework and agile practices enhanced our development workflow.}, language = {en} } @article{KoskinenKairikkoSuonpaeae2021, author = {Koskinen, Johanna and Kairikko, Anette and Suonp{\"a}{\"a}, Maija}, title = {Hybrid MOOCs Enabling Global Collaboration Between Learners}, series = {EMOOCs 2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51691}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-516917}, pages = {35 -- 48}, year = {2021}, abstract = {The COVID-19 pandemic has accelerated the pace of digital transformation, which has forced people to quickly adapt to working and collaborating online. Learning in digital environments has without a doubt gained increased significance during this rather unique time and, therefore, Massive Open Online Courses (MOOCs) have more potential to attract a wider target audience. This has also brought about more possibilities for global collaboration among learners as learning is not limited to physical spaces. Despite the wide interest in MOOCs, there is a need for further research on the global collaboration potential they offer. The aim of this paper is to adopt an action research approach to study how a hybrid MOOC design enables learners' global collaboration. During the years 2019-2020 together with an international consortium called Corship (Corporate Edupreneurship) we jointly designed, created and implemented a hybrid model MOOC, called the "Co-innovation Journey for Startups and Corporates". It was targeted towards startup entrepreneurs, corporate representatives and higher education students and it was funded by the EU. The MOOC started with 2,438 enrolled learners and the completion rate for the first four weeks was 29.7\%. Out of these 208 learners enrolled for the last two weeks, which in turn had a completion rate of 58\%. These figures were clearly above the general average for MOOCs. According to our findings, we argue that a hybrid MOOC design may foster global collaboration within a learning community even beyond the course boundaries. The course included four weeks of independent learning, an xMOOC part, and two weeks of collaborative learning, a cMOOC part. The xMOOC part supported learners in creating a shared knowledge base, which enhanced the collaborative learning when entering the cMOOC part of the course.}, language = {en} } @article{MontiRautenstrauchGhanbarietal.2022, author = {Monti, Remo and Rautenstrauch, Pia and Ghanbari, Mahsa and Rani James, Alva and Kirchler, Matthias and Ohler, Uwe and Konigorski, Stefan and Lippert, Christoph}, title = {Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes}, series = {Nature Communications}, volume = {13}, journal = {Nature Communications}, publisher = {Nature Publishing Group UK}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-022-32864-2}, pages = {16}, year = {2022}, abstract = {Here we present an exome-wide rare genetic variant association study for 30 blood biomarkers in 191,971 individuals in the UK Biobank. We compare gene- based association tests for separate functional variant categories to increase interpretability and identify 193 significant gene-biomarker associations. Genes associated with biomarkers were ~ 4.5-fold enriched for conferring Mendelian disorders. In addition to performing weighted gene-based variant collapsing tests, we design and apply variant-category-specific kernel-based tests that integrate quantitative functional variant effect predictions for mis- sense variants, splicing and the binding of RNA-binding proteins. For these tests, we present a computationally efficient combination of the likelihood- ratio and score tests that found 36\% more associations than the score test alone while also controlling the type-1 error. Kernel-based tests identified 13\% more associations than their gene-based collapsing counterparts and had advantages in the presence of gain of function missense variants. We introduce local collapsing by amino acid position for missense variants and use it to interpret associations and identify potential novel gain of function variants in PIEZO1. Our results show the benefits of investigating different functional mechanisms when performing rare-variant association tests, and demonstrate pervasive rare-variant contribution to biomarker variability.}, language = {en} } @article{EbnerEdelsbrunnerHohlaSejkoraetal.2023, author = {Ebner, Martin and Edelsbrunner, Sarah and Hohla-Sejkora, Katharina and Mair, Bettina and Sch{\"o}n, Sandra and Lipp, Silvia and Steinkellner, Iris and Stojcevic, Ivana and Zwiauer, Charlotte}, title = {Impact assessment of a MOOC platform}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62422}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624222}, pages = {171 -- 186}, year = {2023}, abstract = {In 2020, the project "iMooX - The MOOC Platform as a Service for all Austrian Universities" was launched. It is co-financed by the Austrian Ministry of Education, Science and Research. After half of the funding period, the project management wants to assess and share results and outcomes but also address (potential) additional "impacts" of the MOOC platform. Building upon work on OER impact assessment, this contribution describes in detail how the specific iMooX.at approach of impact measurement was developed. Literature review, stakeholder analysis, and problem-based interviews were the base for developing a questionnaire addressing the defined key stakeholder "MOOC creators". The article also presents the survey results in English for the first time but focuses more on the development, strengths, and weaknesses of the selected methods. The article is seen as a contribution to the further development of impact assessment for MOOC platforms.}, language = {en} } @article{vanEsvelddeVriesBecchettietal.2023, author = {van Esveld, Selma and de Vries, Nardo and Becchetti, Sibilla and Dopper, Sofia and van Valkenburg, Willem}, title = {Impact of Mooc and Other Online Course Development on Campus Education}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Cross, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62078}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-620785}, pages = {1 -- 8}, year = {2023}, abstract = {The TU Delft Extension School for Continuing Education develops and delivers MOOCs, programs and other online courses for lifelong learners and professionals worldwide focused on Science, Engineering \& Design. At the beginning of 2022, we started a project to examine whether creating an online course had any impact on TU Delft campus education. Through a survey, we collected feedback from 68 TU Delft lecturers involved in developing and offering online courses and programs for lifelong learners and professionals. The lecturers reported on the impact of developing an online course on a personal and curricular level. The results showed that the developed online materials, and the acquired skills and experiences from creating online courses, were beneficial for campus education, especially during the transition to remote emergency teaching in the COVID-19 lockdown periods. In this short paper, we will describe the responses in detail and map the benefits and challenges experienced by lecturers when implementing their online course materials and newly acquired educational skills on campus. Finally, we will explore future possibilities to extend the reported, already relevant, impact of MOOCs and of other online courses on campus education.}, language = {en} } @article{SlosarekIbingSchormairetal.2023, author = {Slosarek, Tamara and Ibing, Susanne and Schormair, Barbara and Heyne, Henrike and B{\"o}ttinger, Erwin and Andlauer, Till and Schurmann, Claudia}, title = {Implementation and evaluation of personal genetic testing as part of genomics analysis courses in German universities}, series = {BMC Medical Genomics}, volume = {16}, journal = {BMC Medical Genomics}, number = {1}, publisher = {BMC}, address = {London}, issn = {1755-8794}, doi = {10.1186/s12920-023-01503-0}, pages = {13}, year = {2023}, abstract = {Purpose Due to the increasing application of genome analysis and interpretation in medical disciplines, professionals require adequate education. Here, we present the implementation of personal genotyping as an educational tool in two genomics courses targeting Digital Health students at the Hasso Plattner Institute (HPI) and medical students at the Technical University of Munich (TUM). Methods We compared and evaluated the courses and the students ' perceptions on the course setup using questionnaires. Results During the course, students changed their attitudes towards genotyping (HPI: 79\% [15 of 19], TUM: 47\% [25 of 53]). Predominantly, students became more critical of personal genotyping (HPI: 73\% [11 of 15], TUM: 72\% [18 of 25]) and most students stated that genetic analyses should not be allowed without genetic counseling (HPI: 79\% [15 of 19], TUM: 70\% [37 of 53]). Students found the personal genotyping component useful (HPI: 89\% [17 of 19], TUM: 92\% [49 of 53]) and recommended its inclusion in future courses (HPI: 95\% [18 of 19], TUM: 98\% [52 of 53]). Conclusion Students perceived the personal genotyping component as valuable in the described genomics courses. The implementation described here can serve as an example for future courses in Europe.}, language = {en} } @book{FreundRaetschHradilaketal.2022, author = {Freund, Rieke and R{\"a}tsch, Jan Philip and Hradilak, Franziska and Vidic, Benedikt and Heß, Oliver and Lißner, Nils and W{\"o}lert, Hendrik and Lincke, Jens and Beckmann, Tom and Hirschfeld, Robert}, title = {Implementing a crowd-sourced picture archive for Bad Harzburg}, number = {149}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-545-3}, issn = {1613-5652}, doi = {10.25932/publishup-56029}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-560291}, publisher = {Universit{\"a}t Potsdam}, pages = {x, 191}, year = {2022}, abstract = {Pictures are a medium that helps make the past tangible and preserve memories. Without context, they are not able to do so. Pictures are brought to life by their associated stories. However, the older pictures become, the fewer contemporary witnesses can tell these stories. Especially for large, analog picture archives, knowledge and memories are spread over many people. This creates several challenges: First, the pictures must be digitized to save them from decaying and make them available to the public. Since a simple listing of all the pictures is confusing, the pictures should be structured accessibly. Second, known information that makes the stories vivid needs to be added to the pictures. Users should get the opportunity to contribute their knowledge and memories. To make this usable for all interested parties, even for older, less technophile generations, the interface should be intuitive and error-tolerant. The resulting requirements are not covered in their entirety by any existing software solution without losing the intuitive interface or the scalability of the system. Therefore, we have developed our digital picture archive within the scope of a bachelor project in cooperation with the Bad Harzburg-Stiftung. For the implementation of this web application, we use the UI framework React in the frontend, which communicates via a GraphQL interface with the Content Management System Strapi in the backend. The use of this system enables our project partner to create an efficient process from scanning analog pictures to presenting them to visitors in an organized and annotated way. To customize the solution for both picture delivery and information contribution for our target group, we designed prototypes and evaluated them with people from Bad Harzburg. This helped us gain valuable insights into our system's usability and future challenges as well as requirements. Our web application is already being used daily by our project partner. During the project, we still came up with numerous ideas for additional features to further support the exchange of knowledge.}, language = {en} } @article{CohenHershcovitchTarazetal.2023, author = {Cohen, Sarel and Hershcovitch, Moshik and Taraz, Martin and Kissig, Otto and Issac, Davis and Wood, Andrew and Waddington, Daniel and Chin, Peter and Friedrich, Tobias}, title = {Improved and optimized drug repurposing for the SARS-CoV-2 pandemic}, series = {PLoS one}, volume = {18}, journal = {PLoS one}, number = {3}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0266572}, pages = {13}, year = {2023}, abstract = {The active global SARS-CoV-2 pandemic caused more than 426 million cases and 5.8 million deaths worldwide. The development of completely new drugs for such a novel disease is a challenging, time intensive process. Despite researchers around the world working on this task, no effective treatments have been developed yet. This emphasizes the importance of drug repurposing, where treatments are found among existing drugs that are meant for different diseases. A common approach to this is based on knowledge graphs, that condense relationships between entities like drugs, diseases and genes. Graph neural networks (GNNs) can then be used for the task at hand by predicting links in such knowledge graphs. Expanding on state-of-the-art GNN research, Doshi et al. recently developed the Dr-COVID model. We further extend their work using additional output interpretation strategies. The best aggregation strategy derives a top-100 ranking of 8,070 candidate drugs, 32 of which are currently being tested in COVID-19-related clinical trials. Moreover, we present an alternative application for the model, the generation of additional candidates based on a given pre-selection of drug candidates using collaborative filtering. In addition, we improved the implementation of the Dr-COVID model by significantly shortening the inference and pre-processing time by exploiting data-parallelism. As drug repurposing is a task that requires high computation and memory resources, we further accelerate the post-processing phase using a new emerging hardware-we propose a new approach to leverage the use of high-capacity Non-Volatile Memory for aggregate drug ranking.}, language = {en} } @article{KonakWegnerArnrich2020, author = {Konak, Orhan and Wegner, Pit and Arnrich, Bert}, title = {IMU-Based Movement Trajectory Heatmaps for Human Activity Recognition}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {24}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20247179}, pages = {15}, year = {2020}, abstract = {Recent trends in ubiquitous computing have led to a proliferation of studies that focus on human activity recognition (HAR) utilizing inertial sensor data that consist of acceleration, orientation and angular velocity. However, the performances of such approaches are limited by the amount of annotated training data, especially in fields where annotating data is highly time-consuming and requires specialized professionals, such as in healthcare. In image classification, this limitation has been mitigated by powerful oversampling techniques such as data augmentation. Using this technique, this work evaluates to what extent transforming inertial sensor data into movement trajectories and into 2D heatmap images can be advantageous for HAR when data are scarce. A convolutional long short-term memory (ConvLSTM) network that incorporates spatiotemporal correlations was used to classify the heatmap images. Evaluation was carried out on Deep Inertial Poser (DIP), a known dataset composed of inertial sensor data. The results obtained suggest that for datasets with large numbers of subjects, using state-of-the-art methods remains the best alternative. However, a performance advantage was achieved for small datasets, which is usually the case in healthcare. Moreover, movement trajectories provide a visual representation of human activities, which can help researchers to better interpret and analyze motion patterns.}, language = {en} } @article{AlarioHoyosDelgadoKloosKiendletal.2023, author = {Alario Hoyos, Carlos and Delgado Kloos, Carlos and Kiendl, Doris and Terzieva, Liliya}, title = {Innovat MOOC}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62456}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624560}, pages = {229 -- 237}, year = {2023}, abstract = {The COVID-19 pandemic has revealed the importance for university teachers to have adequate pedagogical and technological competences to cope with the various possible educational scenarios (face-to-face, online, hybrid, etc.), making use of appropriate active learning methodologies and supporting technologies to foster a more effective learning environment. In this context, the InnovaT project has been an important initiative to support the development of pedagogical and technological competences of university teachers in Latin America through several trainings aiming to promote teacher innovation. These trainings combined synchronous online training through webinars and workshops with asynchronous online training through the MOOC "Innovative Teaching in Higher Education." This MOOC was released twice. The first run took place right during the lockdown of 2020, when Latin American teachers needed urgent training to move to emergency remote teaching overnight. The second run took place in 2022 with the return to face-to-face teaching and the implementation of hybrid educational models. This article shares the results of the design of the MOOC considering the constraints derived from the lockdowns applied in each country, the lessons learned from the delivery of such a MOOC to Latin American university teachers, and the results of the two runs of the MOOC.}, language = {en} } @article{KhlaisangDuangchindaThammetaretal.2023, author = {Khlaisang, Jintavee and Duangchinda, Vorasuang and Thammetar, Thapanee and Theeraroungchaisri, Anuchai}, title = {Instructional design for work-based skill MOOCs}, series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, journal = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?}, editor = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-62431}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624318}, pages = {221 -- 227}, year = {2023}, abstract = {As Thailand moves towards becoming an innovation-driven economy, the need for human capital development has become crucial. Work-based skill MOOCs, offered on Thai MOOC, a national digital learning platform launched by Thailand Cyber University Project, ministry of Higher Education, Science, Research and Innovation, provide an effective way to overcome this challenge. This paper discusses the challenges faced in designing an instruction for work-based skill MOOCs that can serve as a foundation model for many more to come. The instructional design of work-based skill courses in Thai MOOC involves four simple steps, including course selection, learning from accredited providers, course requirements completion, and certification of acquired skills. The development of such courses is ongoing at the higher education level, vocational level, and pre-university level, which serve as a foundation model for many more work-based skill MOOC that will be offered on Thai MOOC soon. The instructional design of work-based skills courses should focus on the development of currently demanded professional competencies and skills, increasing the efficiency of work in the organization, creativity, and happiness in life that meets the human resources needs of industries in the 4.0 economy era in Thailand. This paper aims to present the challenges of designing instruction for work-based skill MOOCs and suggests effective ways to design instruction to enhance workforce development in Thailand.}, language = {en} } @article{PonceSrinathAllegue2021, author = {Ponce, Eva and Srinath, Sindhu and Allegue, Laura}, title = {Integrating Community Teaching in MOOCs}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51712}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517123}, pages = {95 -- 109}, year = {2021}, abstract = {The MITx MicroMasters Program in Supply Chain Management (SCM) is a Massive Open Online Course (MOOC) based program that aims to impart quantitative and qualitative knowledge to SCM enthusiasts all around the world. The program that started in 2014 with just one course, now offers 5 courses and one final proctored exam, which allows a learner to gain a MicroMasters credential upon completion. While the courses are delivered in the form of pre-recorded videos by the faculty members of Massachusetts Institute of Technology (MIT), the questions and comments posted by learners in discussion forums are addressed by a group of Community Teaching Assistants (CTAs) who volunteer for this role. The MITx staff carefully selects CTAs for each run of the individual courses as they take on a co-facilitator's role in the program. This paper highlights the importance of community teaching, discusses the profile of CTAs involved with the program, their recruitment, training, tasks and responsibilities, engagement, and rewarding process. In the end we also share a few recommendations based on the lessons learned in community teaching during the last five years of running more than 45 MOOC courses, that could help other MOOC teams deliver a high-touch experience.}, language = {en} } @article{PerscheidGrasnickUflacker2019, author = {Perscheid, Cindy and Grasnick, Bastien and Uflacker, Matthias}, title = {Integrative Gene Selection on Gene Expression Data}, series = {Journal of Integrative Bioinformatics}, volume = {16}, journal = {Journal of Integrative Bioinformatics}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {1613-4516}, doi = {10.1515/jib-2018-0064}, pages = {17}, year = {2019}, abstract = {The advance of high-throughput RNA-Sequencing techniques enables researchers to analyze the complete gene activity in particular cells. From the insights of such analyses, researchers can identify disease-specific expression profiles, thus understand complex diseases like cancer, and eventually develop effective measures for diagnosis and treatment. The high dimensionality of gene expression data poses challenges to its computational analysis, which is addressed with measures of gene selection. Traditional gene selection approaches base their findings on statistical analyses of the actual expression levels, which implies several drawbacks when it comes to accurately identifying the underlying biological processes. In turn, integrative approaches include curated information on biological processes from external knowledge bases during gene selection, which promises to lead to better interpretability and improved predictive performance. Our work compares the performance of traditional and integrative gene selection approaches. Moreover, we propose a straightforward approach to integrate external knowledge with traditional gene selection approaches. We introduce a framework enabling the automatic external knowledge integration, gene selection, and evaluation. Evaluation results prove our framework to be a useful tool for evaluation and show that integration of external knowledge improves overall analysis results.}, language = {en} } @book{MaximovaSchneiderGiese2021, author = {Maximova, Maria and Schneider, Sven and Giese, Holger}, title = {Interval probabilistic timed graph transformation systems}, number = {134}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-502-6}, issn = {1613-5652}, doi = {10.25932/publishup-51289}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-512895}, publisher = {Universit{\"a}t Potsdam}, pages = {58}, year = {2021}, abstract = {The formal modeling and analysis is of crucial importance for software development processes following the model based approach. We present the formalism of Interval Probabilistic Timed Graph Transformation Systems (IPTGTSs) as a high-level modeling language. This language supports structure dynamics (based on graph transformation), timed behavior (based on clocks, guards, resets, and invariants as in Timed Automata (TA)), and interval probabilistic behavior (based on Discrete Interval Probability Distributions). That is, for the probabilistic behavior, the modeler using IPTGTSs does not need to provide precise probabilities, which are often impossible to obtain, but rather provides a probability range instead from which a precise probability is chosen nondeterministically. In fact, this feature on capturing probabilistic behavior distinguishes IPTGTSs from Probabilistic Timed Graph Transformation Systems (PTGTSs) presented earlier. Following earlier work on Interval Probabilistic Timed Automata (IPTA) and PTGTSs, we also provide an analysis tool chain for IPTGTSs based on inter-formalism transformations. In particular, we provide in our tool AutoGraph a translation of IPTGTSs to IPTA and rely on a mapping of IPTA to Probabilistic Timed Automata (PTA) to allow for the usage of the Prism model checker. The tool Prism can then be used to analyze the resulting PTA w.r.t. probabilistic real-time queries asking for worst-case and best-case probabilities to reach a certain set of target states in a given amount of time.}, language = {en} } @book{SchneiderMaximovaGiese2022, author = {Schneider, Sven and Maximova, Maria and Giese, Holger}, title = {Invariant Analysis for Multi-Agent Graph Transformation Systems using k-Induction}, number = {143}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-531-6}, issn = {1613-5652}, doi = {10.25932/publishup-54585}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-545851}, publisher = {Universit{\"a}t Potsdam}, pages = {37}, year = {2022}, abstract = {The analysis of behavioral models such as Graph Transformation Systems (GTSs) is of central importance in model-driven engineering. However, GTSs often result in intractably large or even infinite state spaces and may be equipped with multiple or even infinitely many start graphs. To mitigate these problems, static analysis techniques based on finite symbolic representations of sets of states or paths thereof have been devised. We focus on the technique of k-induction for establishing invariants specified using graph conditions. To this end, k-induction generates symbolic paths backwards from a symbolic state representing a violation of a candidate invariant to gather information on how that violation could have been reached possibly obtaining contradictions to assumed invariants. However, GTSs where multiple agents regularly perform actions independently from each other cannot be analyzed using this technique as of now as the independence among backward steps may prevent the gathering of relevant knowledge altogether. In this paper, we extend k-induction to GTSs with multiple agents thereby supporting a wide range of additional GTSs. As a running example, we consider an unbounded number of shuttles driving on a large-scale track topology, which adjust their velocity to speed limits to avoid derailing. As central contribution, we develop pruning techniques based on causality and independence among backward steps and verify that k-induction remains sound under this adaptation as well as terminates in cases where it did not terminate before.}, language = {en} } @article{JonsonCarlonGaddemHernandezReyesetal.2021, author = {Jonson Carlon, May Kristine and Gaddem, Mohamed Rami and Hern{\´a}ndez Reyes, C{\´e}sar Augusto and Nagahama, Toru and Cross, Jeffrey S.}, title = {Investigating Mechanical Engineering Learners' Satisfaction with a Revised Monozukuri MOOC}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51726}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517266}, pages = {237 -- 247}, year = {2021}, abstract = {Aside from providing instructional materials to the public, developing massive open online courses (MOOCs) can benefit institutions in different ways. Some examples include providing training opportunities for their students aspiring to work in the online learning space, strengthening its brand recognition through courses appealing to enthusiasts, and enabling online linkages with other universities. One such example is the monozukuri MOOC offered by the Tokyo Institute of Technology on edX, which initially presented the Japanese philosophy of making things in the context of a mechanical engineering course. In this paper, we describe the importance of involving a course development team with a diverse background. The monozukuri MOOC and its revision enabled us to showcase an otherwise distinctively Japanese topic (philosophy) as an intersection of various topics of interest to learners with an equally diverse background. The revision resulted in discussing monozukuri in a mechanical engineering lesson and how monozukuri is actively being practiced in the Japanese workplace and academic setting while juxtaposing it to the relatively Western concept of experiential learning. Aside from presenting the course with a broader perspective, the revision had been an exercise for its team members on working in a multicultural environment within a Japanese institution, thus developing their project management and communication skills.}, language = {en} } @book{SeitzLinckeReinetal.2021, author = {Seitz, Klara and Lincke, Jens and Rein, Patrick and Hirschfeld, Robert}, title = {Language and tool support for 3D crochet patterns}, number = {137}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-505-7}, issn = {1613-5652}, doi = {10.25932/publishup-49253}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-492530}, publisher = {Universit{\"a}t Potsdam}, pages = {vii, 94}, year = {2021}, abstract = {Crochet is a popular handcraft all over the world. While other techniques such as knitting or weaving have received technical support over the years through machines, crochet is still a purely manual craft. Not just the act of crochet itself is manual but also the process of creating instructions for new crochet patterns, which is barely supported by domain specific digital solutions. This leads to unstructured and often also ambiguous and erroneous pattern instructions. In this report, we propose a concept to digitally represent crochet patterns. This format incorporates crochet techniques which allows domain specific support for crochet pattern designers during the pattern creation and instruction writing process. As contributions, we present a thorough domain analysis, the concept of a graph structure used as domain specific language to specify crochet patterns and a prototype of a projectional editor using the graph as representation format of patterns and a diagramming system to visualize them in 2D and 3D. By analyzing the domain, we learned about crochet techniques and pain points of designers in their pattern creation workflow. These insights are the basis on which we defined the pattern representation. In order to evaluate our concept, we built a prototype by which the feasibility of the concept is shown and we tested the software with professional crochet designers who approved of the concept.}, language = {en} } @article{GarrelsKhodabakhshRenardetal.2023, author = {Garrels, Tim and Khodabakhsh, Athar and Renard, Bernhard Y. and Baum, Katharina}, title = {LazyFox: fast and parallelized overlapping community detection in large graphs}, series = {PEERJ Computer Science}, volume = {9}, journal = {PEERJ Computer Science}, publisher = {PeerJ Inc.}, address = {London}, issn = {2376-5992}, doi = {10.7717/peerj-cs.1291}, pages = {30}, year = {2023}, abstract = {The detection of communities in graph datasets provides insight about a graph's underlying structure and is an important tool for various domains such as social sciences, marketing, traffic forecast, and drug discovery. While most existing algorithms provide fast approaches for community detection, their results usually contain strictly separated communities. However, most datasets would semantically allow for or even require overlapping communities that can only be determined at much higher computational cost. We build on an efficient algorithm, FOX, that detects such overlapping communities. FOX measures the closeness of a node to a community by approximating the count of triangles which that node forms with that community. We propose LAZYFOX, a multi-threaded adaptation of the FOX algorithm, which provides even faster detection without an impact on community quality. This allows for the analyses of significantly larger and more complex datasets. LAZYFOX enables overlapping community detection on complex graph datasets with millions of nodes and billions of edges in days instead of weeks. As part of this work, LAZYFOX's implementation was published and is available as a tool under an MIT licence at https://github.com/TimGarrels/LazyFox.}, language = {en} } @article{BlackwellWiltrout2021, author = {Blackwell, Virginia Katherine and Wiltrout, Mary Ellen}, title = {Learning During COVID-19}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-512-5}, doi = {10.25932/publishup-51725}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517251}, pages = {219 -- 236}, year = {2021}, abstract = {During the COVID-19 pandemic, learning in higher education and beyond shifted en masse to online formats, with the short- and long-term consequences for Massive Open Online Course (MOOC) platforms, learners, and creators still under evaluation. In this paper, we sought to determine whether the COVID-19 pandemic and this shift to online learning led to increased learner engagement and attainment in a single introductory biology MOOC through evaluating enrollment, proportional and individual engagement, and verification and performance data. As this MOOC regularly operates each year, we compared these data collected from two course runs during the pandemic to three pre-pandemic runs. During the first pandemic run, the number and rate of learners enrolling in the course doubled when compared to prior runs, while the second pandemic run indicated a gradual return to pre-pandemic enrollment. Due to higher enrollment, more learners viewed videos, attempted problems, and posted to the discussion forums during the pandemic. Participants engaged with forums in higher proportions in both pandemic runs, but the proportion of participants who viewed videos decreased in the second pandemic run relative to the prior runs. A higher percentage of learners chose to pursue a certificate via the verified track in each pandemic run, though a smaller proportion earned certification in the second pandemic run. During the pandemic, more enrolled learners did not necessarily correlate to greater engagement by all metrics. While verified-track learner performance varied widely during each run, the effects of the pandemic were not uniform for learners, much like in other aspects of life. As such, individual engagement trends in the first pandemic run largely resemble pre-pandemic metrics but with more learners overall, while engagement trends in the second pandemic run are less like pre-pandemic metrics, hinting at learner "fatigue". This study serves to highlight the life-long learning opportunity that MOOCs offer is even more critical when traditional education modes are disrupted and more people are at home or unemployed. This work indicates that this boom in MOOC participation may not remain at a high level for the longer term in any one course, but overall, the number of MOOCs, programs, and learners continues to grow.}, language = {en} } @book{DuerschReinMattisetal.2022, author = {D{\"u}rsch, Falco and Rein, Patrick and Mattis, Toni and Hirschfeld, Robert}, title = {Learning from failure}, number = {145}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-528-6}, issn = {1613-5652}, doi = {10.25932/publishup-53755}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-537554}, publisher = {Universit{\"a}t Potsdam}, pages = {87}, year = {2022}, abstract = {Regression testing is a widespread practice in today's software industry to ensure software product quality. Developers derive a set of test cases, and execute them frequently to ensure that their change did not adversely affect existing functionality. As the software product and its test suite grow, the time to feedback during regression test sessions increases, and impedes programmer productivity: developers wait longer for tests to complete, and delays in fault detection render fault removal increasingly difficult. Test case prioritization addresses the problem of long feedback loops by reordering test cases, such that test cases of high failure probability run first, and test case failures become actionable early in the testing process. We ask, given test execution schedules reconstructed from publicly available data, to which extent can their fault detection efficiency improved, and which technique yields the most efficient test schedules with respect to APFD? To this end, we recover regression 6200 test sessions from the build log files of Travis CI, a popular continuous integration service, and gather 62000 accompanying changelists. We evaluate the efficiency of current test schedules, and examine the prioritization results of state-of-the-art lightweight, history-based heuristics. We propose and evaluate a novel set of prioritization algorithms, which connect software changes and test failures in a matrix-like data structure. Our studies indicate that the optimization potential is substantial, because the existing test plans score only 30\% APFD. The predictive power of past test failures proves to be outstanding: simple heuristics, such as repeating tests with failures in recent sessions, result in efficiency scores of 95\% APFD. The best-performing matrix-based heuristic achieves a similar score of 92.5\% APFD. In contrast to prior approaches, we argue that matrix-based techniques are useful beyond the scope of effective prioritization, and enable a number of use cases involving software maintenance. We validate our findings from continuous integration processes by extending a continuous testing tool within development environments with means of test prioritization, and pose further research questions. We think that our findings are suited to propel adoption of (continuous) testing practices, and that programmers' toolboxes should contain test prioritization as an existential productivity tool.}, language = {en} } @article{SengCarlonGayedetal.2021, author = {Seng, Cheyvuth and Carlon, May Kristine Jonson and Gayed, John Maurice and Cross, Jeffrey S.}, title = {Long-Term Effects of Short-Term Intervention Using MOOCs for Developing Cambodian Undergraduate Research Skills}, series = {EMOOCs 2021}, volume = {2021}, journal = {EMOOCs 2021}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-51692}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-516929}, pages = {49 -- 62}, year = {2021}, abstract = {Developing highly skilled researchers is essential to accelerate the economic progress of developing countries such as Cambodia in South East Asia. While there is continuing research investigating Cambodia's potential to cultivate such a workforce, the circumstances of undergraduate students in public provincial universities do not receive ample attention. This is crucial as numerous multinational corporations are participating via foreign direct investments in special economic zones at the border provinces and need talented human resources in Cambodia as well as in neighboring Southeast Asian countries such as Thailand and Vietnam. Student's research capability growth starts with one's belief in their capacity to use the necessary information tools and their potential to succeed in research. In this research paper, we look at how such beliefs, specifically research self-efficacy and information literacy, can be developed through a short-term intervention that uses MOOCs and assess their long-term effects. Our previous research has shown that short-term training intervention has immediate positive effects on the undergraduate students' self-efficacies in Cambodian public provincial universities. In this paper, we present the follow-up study results conducted sixteen months after the said short-term training intervention. Results reveal that from follow-up evaluations that while student's self-efficacies were significantly higher than before the short-term intervention was completed, they were lower than immediately after the intervention. Thus, while perfunctory interventions such as merely introducing the students to MOOCs and other relevant research tools over as little as three weeks can have significant positive effects, efforts must be made to sustain the benefits gained. This implication is essential to developing countries such as Cambodia that need low-cost solutions with immediate positive results in developing human resources to conduct research, particularly in areas far from more developed capital cities.}, language = {en} } @article{ShamsWangRoineetal.2022, author = {Shams, Boshra and Wang, Ziqian and Roine, Timo and Aydogan, Dogu Baran and Vajkoczy, Peter and Lippert, Christoph and Picht, Thomas and Fekonja, Lucius Samo}, title = {Machine learning-based prediction of motor status in glioma patients using diffusion MRI metrics along the corticospinal tract}, series = {Brain communications}, volume = {4}, journal = {Brain communications}, number = {3}, publisher = {Oxford University Press}, address = {Oxford}, issn = {2632-1297}, doi = {10.1093/braincomms/fcac141}, pages = {17}, year = {2022}, abstract = {Shams et al. report that glioma patients' motor status is predicted accurately by diffusion MRI metrics along the corticospinal tract based on support vector machine method, reaching an overall accuracy of 77\%. They show that these metrics are more effective than demographic and clinical variables. Along tract statistics enables white matter characterization using various diffusion MRI metrics. These diffusion models reveal detailed insights into white matter microstructural changes with development, pathology and function. Here, we aim at assessing the clinical utility of diffusion MRI metrics along the corticospinal tract, investigating whether motor glioma patients can be classified with respect to their motor status. We retrospectively included 116 brain tumour patients suffering from either left or right supratentorial, unilateral World Health Organization Grades II, III and IV gliomas with a mean age of 53.51 +/- 16.32 years. Around 37\% of patients presented with preoperative motor function deficits according to the Medical Research Council scale. At group level comparison, the highest non-overlapping diffusion MRI differences were detected in the superior portion of the tracts' profiles. Fractional anisotropy and fibre density decrease, apparent diffusion coefficient axial diffusivity and radial diffusivity increase. To predict motor deficits, we developed a method based on a support vector machine using histogram-based features of diffusion MRI tract profiles (e.g. mean, standard deviation, kurtosis and skewness), following a recursive feature elimination method. Our model achieved high performance (74\% sensitivity, 75\% specificity, 74\% overall accuracy and 77\% area under the curve). We found that apparent diffusion coefficient, fractional anisotropy and radial diffusivity contributed more than other features to the model. Incorporating the patient demographics and clinical features such as age, tumour World Health Organization grade, tumour location, gender and resting motor threshold did not affect the model's performance, revealing that these features were not as effective as microstructural measures. These results shed light on the potential patterns of tumour-related microstructural white matter changes in the prediction of functional deficits.}, language = {en} }