@article{ZoccaratoSherMikietal.2022,
  author    = {Zoccarato, Luca and Sher, Daniel and Miki, Takeshi and Segre, Daniel and Grossart, Hans-Peter},
  title     = {A comparative whole-genome approach identifies bacterial traits for marine microbial interactions},
  series = {Communications biology},
  volume    = {5},
  journal   = {Communications biology},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {2399-3642},
  doi       = {10.1038/s42003-022-03184-4},
  pages     = {13},
  year      = {2022},
  abstract  = {Luca Zoccarato, Daniel Sher et al. leverage publicly available bacterial genomes from marine and other environments to examine traits underlying microbial interactions. Their results provide a valuable resource to investigate clusters of functional and linked traits to better understand marine bacteria community assembly and dynamics. Microbial interactions shape the structure and function of microbial communities with profound consequences for biogeochemical cycles and ecosystem health. Yet, most interaction mechanisms are studied only in model systems and their prevalence is unknown. To systematically explore the functional and interaction potential of sequenced marine bacteria, we developed a trait-based approach, and applied it to 473 complete genomes (248 genera), representing a substantial fraction of marine microbial communities. We identified genome functional clusters (GFCs) which group bacterial taxa with common ecology and life history. Most GFCs revealed unique combinations of interaction traits, including the production of siderophores (10\% of genomes), phytohormones (3-8\%) and different B vitamins (57-70\%). Specific GFCs, comprising Alpha- and Gammaproteobacteria, displayed more interaction traits than expected by chance, and are thus predicted to preferentially interact synergistically and/or antagonistically with bacteria and phytoplankton. Linked trait clusters (LTCs) identify traits that may have evolved to act together (e.g., secretion systems, nitrogen metabolism regulation and B vitamin transporters), providing testable hypotheses for complex mechanisms of microbial interactions. Our approach translates multidimensional genomic information into an atlas of marine bacteria and their putative functions, relevant for understanding the fundamental rules that govern community assembly and dynamics.},
  language  = {en}
}
@article{MacdonaldOteroButler2021,
  author    = {Macdonald, Elena and Otero, Noelia and Butler, Tim},
  title     = {A comparison of long-term trends in observations and emission inventories of NOx},
  series = {Atmospheric chemistry and physics / European Geosciences Union},
  volume    = {21},
  journal   = {Atmospheric chemistry and physics / European Geosciences Union},
  number    = {5},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1680-7316},
  doi       = {10.5194/acp-21-4007-2021},
  pages     = {4007 -- 4023},
  year      = {2021},
  abstract  = {Air pollution is a pressing issue that is associated with adverse effects on human health, ecosystems, and climate. Despite many years of effort to improve air quality, nitrogen dioxide (NO2) limit values are still regularly exceeded in Europe, particularly in cities and along streets. This study explores how concentrations of nitrogen oxides (NOx = NO + NO2) in European urban areas have changed over the last decades and how this relates to changes in emissions. To do so, the incremental approach was used, comparing urban increments (i.e. urban background minus rural concentrations) to total emissions, and roadside increments (i.e. urban roadside concentrations minus urban background concentrations) to traffic emissions. In total, nine European cities were assessed. The study revealed that potentially confounding factors like the impact of urban pollution at rural monitoring sites through atmospheric transport are generally negligible for NOx. The approach proves therefore particularly useful for this pollutant. The estimated urban increments all showed downward trends, and for the majority of the cities the trends aligned well with the total emissions. However, it was found that factors like a very densely populated surrounding or local emission sources in the rural area such as shipping traffic on inland waterways restrict the application of the approach for some cities. The roadside increments showed an overall very diverse picture in their absolute values and trends and also in their relation to traffic emissions. This variability and the discrepancies between roadside increments and emissions could be attributed to a combination of local influencing factors at the street level and different aspects introducing inaccuracies to the trends of the emis-sion inventories used, including deficient emission factors. Applying the incremental approach was evaluated as useful for long-term pan-European studies, but at the same time it was found to be restricted to certain regions and cities due to data availability issues. The results also highlight that using emission inventories for the prediction of future health impacts and compliance with limit values needs to consider the distinct variability in the concentrations not only across but also within cities.},
  language  = {en}
}
@misc{MotaLeckeltGeukesetal.2018,
  author    = {Mota, Simon and Leckelt, Marius and Geukes, Katharina and Nestler, Steffen and Humberg, Sarah and Schr{\"o}der-Abe, Michela and Schmukle, Stefan C. and Back, Mitja D.},
  title     = {A comprehensive examination of narcissists' self-perceived and actual socioemotional cognition ability},
  series = {Collabra: Psychology},
  volume    = {5},
  journal   = {Collabra: Psychology},
  number    = {1},
  publisher = {University of California Press},
  address   = {Oakland},
  issn      = {2474-7394},
  doi       = {10.1525/collabra.174},
  pages     = {25},
  year      = {2018},
  abstract  = {Narcissists are assumed to lack the motivation and ability to share and understand the mental states of others. Prior empirical research, however, has yielded inconclusive findings and has differed with respect to the specific aspects of narcissism and socioemotional cognition that have been examined. Here, we propose a differentiated facet approach that can be applied across research traditions and that distinguishes between facets of narcissism (agentic vs. antagonistic) on the one hand, and facets of socioemotional cognition ability (SECA; self-perceived vs. actual) on the other. Using five nonclinical samples in two studies (total N = 602), we investigated the effect of facets of grandiose narcissism on aspects of socioemotional cognition across measures of affective and cognitive empathy, Theory of Mind, and emotional intelligence, while also controlling for general reasoning ability. Across both studies, agentic facets of narcissism were found to be positively related to perceived SECA, whereas antagonistic facets of narcissism were found to be negatively related to perceived SECA. However, both narcissism facets were negatively related to actual SECA. Exploratory condition-based regression analyses further showed that agentic narcissists had a higher directed discrepancy between perceived and actual SECA: They self-enhanced their socio-emotional capacities. Implications of these results for the multifaceted theoretical understanding of the narcissism-SECA link are discussed.},
  language  = {en}
}
@article{StaufferMengeshaSeifertetal.2022,
  author    = {Stauffer, Maxime and Mengesha, Isaak and Seifert, Konrad and Krawczuk, Igor and Fischer, Jens and Serugendo, Giovanna Di Marzo},
  title     = {A computational turn in policy process studies},
  series = {Complexity},
  volume    = {2022},
  journal   = {Complexity},
  publisher = {Wiley-Hindawi},
  address   = {London},
  issn      = {1076-2787},
  doi       = {10.1155/2022/8210732},
  pages     = {17},
  year      = {2022},
  abstract  = {The past three decades of policy process studies have seen the emergence of a clear intellectual lineage with regard to complexity. Implicitly or explicitly, scholars have employed complexity theory to examine the intricate dynamics of collective action in political contexts. However, the methodological counterparts to complexity theory, such as computational methods, are rarely used and, even if they are, they are often detached from established policy process theory. Building on a critical review of the application of complexity theory to policy process studies, we present and implement a baseline model of policy processes using the logic of coevolving networks. Our model suggests that an actor's influence depends on their environment and on exogenous events facilitating dialogue and consensus-building. Our results validate previous opinion dynamics models and generate novel patterns. Our discussion provides ground for further research and outlines the path for the field to achieve a computational turn.},
  language  = {en}
}
@article{ChapmanLantOhashietal.2019,
  author    = {Chapman, Eric M. and Lant, Benjamin and Ohashi, Yota and Yu, Bin and Schertzberg, Michael and Go, Christopher and Dogra, Deepika and Koskimaki, Janne and Girard, Romuald and Li, Yan and Fraser, Andrew G. and Awad, Issam A. and Abdelilah-Seyfried, Salim and Gingras, Anne-Claude and Derry, William Brent},
  title     = {A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis},
  series = {Nature Communications},
  volume    = {10},
  journal   = {Nature Communications},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-019-09829-z},
  pages     = {15},
  year      = {2019},
  abstract  = {Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.},
  language  = {en}
}
@article{WolffGastEversetal.2021,
  author    = {Wolff, Martin and Gast, Klaus and Evers, Andreas and Kurz, Michael and Pfeiffer-Marek, Stefania and Sch{\"u}ler, Anja and Seckler, Robert and Thalhammer, Anja},
  title     = {A Conserved Hydrophobic Moiety and Helix-Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4},
  series = {Biomolecules},
  volume    = {11},
  journal   = {Biomolecules},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2218-273X},
  doi       = {10.3390/biom11091305},
  pages     = {20},
  year      = {2021},
  abstract  = {Exendin-4 is a pharmaceutical peptide used in the control of insulin secretion. Structural information on exendin-4 and related peptides especially on the level of quaternary structure is scarce. We present the first published association equilibria of exendin-4 directly measured by static and dynamic light scattering. We show that exendin-4 oligomerization is pH dependent and that these oligomers are of low compactness. We relate our experimental results to a structural hypothesis to describe molecular details of exendin-4 oligomers. Discussion of the validity of this hypothesis is based on NMR, circular dichroism and fluorescence spectroscopy, and light scattering data on exendin-4 and a set of exendin-4 derived peptides. The essential forces driving oligomerization of exendin-4 are helix-helix interactions and interactions of a conserved hydrophobic moiety. Our structural hypothesis suggests that key interactions of exendin-4 monomers in the experimentally supported trimer take place between a defined helical segment and a hydrophobic triangle constituted by the Phe22 residues of the three monomeric subunits. Our data rationalize that Val19 might function as an anchor in the N-terminus of the interacting helix-region and that Trp25 is partially shielded in the oligomer by C-terminal amino acids of the same monomer. Our structural hypothesis suggests that the Trp25 residues do not interact with each other, but with C-terminal Pro residues of their own monomers.},
  language  = {en}
}
@article{MaierWiljesHartungetal.2022,
  author    = {Maier, Corinna Sabrina and Wiljes, Jana de and Hartung, Niklas and Kloft, Charlotte and Huisinga, Wilhelm},
  title     = {A continued learning approach for model-informed precision dosing},
  series = {CPT: pharmacometrics \& systems pharmacology},
  volume    = {11},
  journal   = {CPT: pharmacometrics \& systems pharmacology},
  number    = {2},
  publisher = {London},
  address   = {Nature Publ. Group},
  issn      = {2163-8306},
  doi       = {10.1002/psp4.12745},
  pages     = {185 -- 198},
  year      = {2022},
  abstract  = {Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment. Structural models and prior parameter distributions used in MIPD approaches typically build on prior clinical trials that involve only a limited number of patients selected according to some exclusion/inclusion criteria. Compared to the prior clinical trial population, the patient population in clinical practice can be expected to also include altered behavior and/or increased interindividual variability, the extent of which, however, is typically unknown. Here, we address the question of how to adapt and refine models on the level of the model parameters to better reflect this real-world diversity. We propose an approach for continued learning across patients during MIPD using a sequential hierarchical Bayesian framework. The approach builds on two stages to separate the update of the individual patient parameters from updating the population parameters. Consequently, it enables continued learning across hospitals or study centers, because only summary patient data (on the level of model parameters) need to be shared, but no individual TDM data. We illustrate this continued learning approach with neutrophil-guided dosing of paclitaxel. The present study constitutes an important step toward building confidence in MIPD and eventually establishing MIPD increasingly in everyday therapeutic use.},
  language  = {en}
}
@techreport{BaganzdeTeresaLinggetal.2023,
  type      = {Working Paper},
  author    = {Baganz, Melissa and de Teresa, Aurelia G{\´o}mez and Lingg, Rosana T. and Montijo, Yuriditzi Pascacio},
  title     = {A critical assessment on National Action Plans},
  series = {Staat, Recht und Politik - Forschungs- und Diskussionspapiere},
  journal   = {Staat, Recht und Politik - Forschungs- und Diskussionspapiere},
  number    = {13},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2509-6974},
  doi       = {10.25932/publishup-57679},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-576797},
  pages     = {11},
  year      = {2023},
  abstract  = {National Action Plans (NAPs) have been increas-ingly adopted world-wide after the Vienna Dec-laration in 1993, where it was urged to consider the improvement and promotion of Human Rights. In this paper, we discuss their usefulness and success by analysing the challenges present-ed during NAP processes as well as the benefits this set of actions entails: The challenges for their implementation outweigh its actual benefits. Nevertheless, NAPs have great potential. Based on new research, we elaborate a set of recom-mendations for improving the design and imple-mentation of national action planning. In order to effectively bring NAP into practice, we consider it crucial to plan and analyse every state local circumstances in detail. The latter is important, since the implementation of a concrete set of actions is intended to directly transform and improve the local living conditions of the people. In a long-term perspective, we defend the benefit of NAP's implementation for complying obliga-tions set up by HR treaties.},
  language  = {en}
}
@techreport{Hajos2023,
  type      = {Working Paper},
  author    = {Hajos, Yael},
  title     = {A Critical Overview of the Public Health Emergency of International Concern Mechanism},
  series = {Staat, Recht und Politik - Forschungs- und Diskussionspapiere},
  journal   = {Staat, Recht und Politik - Forschungs- und Diskussionspapiere},
  number    = {15},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2509-6974},
  doi       = {10.25932/publishup-58523},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-585238},
  pages     = {20},
  year      = {2023},
  abstract  = {The last years have been affected by Covid-19 and the international emergency mecha-nism to deal with health-related threats. The effects of this period manifested differ-ently worldwide, depending on matters such as international relations, national policies, power dynamics etc. Additionally, the impact of this time will likely have long-term effects which are yet to be known. This paper gives a critical overview of the Public Health Emergency of International Concern (PHEIC) mechanism in the context of Covid-19. It does so by explaining the legal framework for states of emergency, specifically in the context of a PHEIC, while considering its restrictions and limitations on human rights. It further outlines issues in the manifestation of global protections and limitations on human rights during Covid-19. Lastly, considering the likelihood of future PHEICs and the known systemic obstructions, this paper offers ways to im-prove this mechanism from a holistic, non-zero-sum perspective.},
  language  = {en}
}
@article{BrillPassuniPinedaEspichanCuyaetal.2020,
  author    = {Brill, Fabio Alexander and Passuni Pineda, Silvia and Espichan Cuya, Bruno and Kreibich, Heidi},
  title     = {A data-mining approach towards damage modelling for El Nino events in Peru},
  series = {Geomatics, natural hazards and risk},
  volume    = {11},
  journal   = {Geomatics, natural hazards and risk},
  number    = {1},
  publisher = {Routledge, Taylor \& Francis Group},
  address   = {Abingdon},
  issn      = {1947-5705},
  doi       = {10.1080/19475705.2020.1818636},
  pages     = {1966 -- 1990},
  year      = {2020},
  abstract  = {Compound natural hazards likeEl Ninoevents cause high damage to society, which to manage requires reliable risk assessments. Damage modelling is a prerequisite for quantitative risk estimations, yet many procedures still rely on expert knowledge, and empirical studies investigating damage from compound natural hazards hardly exist. A nationwide building survey in Peru after theEl Ninoevent 2017 - which caused intense rainfall, ponding water, flash floods and landslides - enables us to apply data-mining methods for statistical groundwork, using explanatory features generated from remote sensing products and open data. We separate regions of different dominant characteristics through unsupervised clustering, and investigate feature importance rankings for classifying damage via supervised machine learning. Besides the expected effect of precipitation, the classification algorithms select the topographic wetness index as most important feature, especially in low elevation areas. The slope length and steepness factor ranks high for mountains and canyons. Partial dependence plots further hint at amplified vulnerability in rural areas. An example of an empirical damage probability map, developed with a random forest model, is provided to demonstrate the technical feasibility.},
  language  = {en}
}
@article{Ette2021,
  author    = {Ette, Ottmar},
  title     = {A expuls{\~a}o do {\´E}den},
  series = {Literatura e autoritarismo},
  journal   = {Literatura e autoritarismo},
  number    = {25},
  publisher = {Universidade Federal de Santa Maria (UFSM)},
  address   = {Santa Maria},
  issn      = {1679-849X},
  doi       = {10.5902/1679849X65745},
  pages     = {5 -- 42},
  year      = {2021},
  abstract  = {A tem{\´a}tica da migra{\c{c}}{\~a}o est{\´a} intimamente vinculada {\`a} hist{\´o}ria humana, desde a narrativa b{\´i}blica da expuls{\~a}o do para{\´i}so. O ser humano n{\~a}o apenas empregou t{\´e}cnicas cada vez mais sofisticadas para a viol{\^e}ncia, como tamb{\´e}m transmitiu, atrav{\´e}s dos s{\´e}culos, t{\´e}cnicas de conserva{\c{c}}{\~a}o e uso de seu saberconviver. Nesse sentido m{\´o}vel da hist{\´o}ria, e em conson{\^a}ncia com as literaturas do mundo, a partir de suas diversas origens, {\´e} poss{\´i}vel dizer que existe um "Homo migrans" desde que existe o "Homo sapiens". Assim, {\´e} poss{\´i}vel afirmar que as ideias territoriais ou territorializantes com proveni{\^e}ncia hist{\´o}rico-espacial permitem, vez ou outra, reconhecer seus esfor{\c{c}}os para filtrar e isolar a dimens{\~a}o hist{\´o}rico-m{\´o}vel e vetorial da hist{\´o}ria como narrativa, para tentar construir, com a ajuda de ideias est{\´a}ticas, novos lugares da promessa ou da perda, da abund{\^a}ncia ou da queda.},
  language  = {pt}
}
@article{DemalHeiseReizetal.2019,
  author    = {Demal, Till Joscha and Heise, Melina and Reiz, Benedikt and Dogra, Deepika and Braenne, Ingrid and Reichenspurner, Hermann and M{\"a}nner, J{\"o}rg and Aherrahrou, Zouhair and Schunkert, Heribert and Erdmann, Jeanette and Abdelilah-Seyfried, Salim},
  title     = {A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A},
  series = {Scientific reports},
  volume    = {9},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-019-39648-7},
  pages     = {12},
  year      = {2019},
  abstract  = {The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein's anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology.},
  language  = {en}
}
@article{XiaoLiuWangetal.2020,
  author    = {Xiao, Shangbin and Liu, Liu and Wang, Wei and Lorke, Andreas and Woodhouse, Jason Nicholas and Grossart, Hans-Peter},
  title     = {A Fast-Response Automated Gas Equilibrator (FaRAGE) for continuous in situ measurement of CH4 and CO2 dissolved in water},
  series = {Hydrology and earth system sciences : HESS},
  volume    = {24},
  journal   = {Hydrology and earth system sciences : HESS},
  number    = {7},
  publisher = {European Geosciences Union (EGU) ; Copernicus},
  address   = {Munich},
  issn      = {1027-5606},
  doi       = {10.5194/hess-24-3871-2020},
  pages     = {3871 -- 3880},
  year      = {2020},
  abstract  = {Biogenic greenhouse gas emissions, e.g., of methane (CH4) and carbon dioxide (CO2) from inland waters, contribute substantially to global warming. In aquatic systems, dissolved greenhouse gases are highly heterogeneous in both space and time. To better understand the biological and physical processes that affect sources and sinks of both CH4 and CO2, their dissolved concentrations need to be measured with high spatial and temporal resolution. To achieve this goal, we developed the Fast-Response Automated Gas Equilibrator (FaRAGE) for real-time in situ measurement of dissolved CH4 and CO2 concentrations at the water surface and in the water column. FaRAGE can achieve an exceptionally short response time (t(95\%) = 12 s when including the response time of the gas analyzer) while retaining an equilibration ratio of 62.6\% and a measurement accuracy of 0.5\% for CH4. A similar performance was observed for dissolved CO2 (t(95\%) = 10 s, equilibration ratio 67.1 \%). An equilibration ratio as high as 91.8\% can be reached at the cost of a slightly increased response time (16 s). The FaRAGE is capable of continuously measuring dissolved CO2 and CH4 concentrations in the nM-to-submM (10(-9)-10(-3) mol L-1) range with a detection limit of subnM (10(-10) mol L-1), when coupling with a cavity ring-down greenhouse gas analyzer (Picarro GasScouter). FaRAGE allows for the possibility of mapping dissolved concentration in a "quasi" three-dimensional manner in lakes and provides an inexpensive alternative to other commercial gas equilibrators. It is simple to operate and suitable for continuous monitoring with a strong tolerance for suspended particles. While the FaRAGE is developed for inland waters, it can be also applied to ocean waters by tuning the gas-water mixing ratio. The FaRAGE is easily adapted to suit other gas analyzers expanding the range of potential applications, including nitrous oxide and isotopic composition of the gases.},
  language  = {en}
}
@article{LangenhanJaegerBaumetal.2022,
  author    = {Langenhan, Jennifer and Jaeger, Carsten and Baum, Katharina and Simon, Mareike and Lisec, Jan},
  title     = {A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments},
  series = {Metabolites},
  volume    = {12},
  journal   = {Metabolites},
  number    = {5},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2218-1989},
  doi       = {10.3390/metabo12050408},
  pages     = {10},
  year      = {2022},
  abstract  = {The investigation of metabolic fluxes and metabolite distributions within cells by means of tracer molecules is a valuable tool to unravel the complexity of biological systems. Technological advances in mass spectrometry (MS) technology such as atmospheric pressure chemical ionization (APCI) coupled with high resolution (HR), not only allows for highly sensitive analyses but also broadens the usefulness of tracer-based experiments, as interesting signals can be annotated de novo when not yet present in a compound library. However, several effects in the APCI ion source, i.e., fragmentation and rearrangement, lead to superimposed mass isotopologue distributions (MID) within the mass spectra, which need to be corrected during data evaluation as they will impair enrichment calculation otherwise. Here, we present and evaluate a novel software tool to automatically perform such corrections. We discuss the different effects, explain the implemented algorithm, and show its application on several experimental datasets. This adjustable tool is available as an R package from CRAN.},
  language  = {en}
}
@misc{RisbeyLewandowskyCowtanetal.2018,
  author    = {Risbey, James S. and Lewandowsky, Stephan and Cowtan, Kevin and Oreskes, Naomi and Rahmstorf, Stefan and Jokim{\"a}ki, Ari and Foster, Grant},
  title     = {A fluctuation in surface temperature in historical context},
  series = {Environmental research letters},
  volume    = {13},
  journal   = {Environmental research letters},
  number    = {12},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {1748-9326},
  doi       = {10.1088/1748-9326/aaf342},
  pages     = {23},
  year      = {2018},
  abstract  = {This work reviews the literature on an alleged global warming 'pause' in global mean surface temperature (GMST) to determine how it has been defined, what time intervals are used to characterise it, what data are used to measure it, and what methods used to assess it. We test for 'pauses', both in the normally understood meaning of the term to mean no warming trend, as well as for a 'pause' defined as a substantially slower trend in GMST. The tests are carried out with the historical versions of GMST that existed for each pause-interval tested, and with current versions of each of the GMST datasets. The tests are conducted following the common (but questionable) practice of breaking the linear fit at the start of the trend interval ('broken' trends), and also with trends that are continuous with the data bordering the trend interval. We also compare results when appropriate allowance is made for the selection bias problem. The results show that there is little or no statistical evidence for a lack of trend or slower trend in GMST using either the historical data or the current data. The perception that there was a 'pause' in GMST was bolstered by earlier biases in the data in combination with incomplete statistical testing.},
  language  = {en}
}
@article{Zass2020,
  author    = {Zass, Alexander},
  title     = {A Gibbs point process of diffusions: Existence and uniqueness},
  series = {Lectures in pure and applied mathematics},
  journal   = {Lectures in pure and applied mathematics},
  number    = {6},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-485-2},
  issn      = {2199-4951},
  doi       = {10.25932/publishup-47195},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-471951},
  pages     = {13 -- 22},
  year      = {2020},
  language  = {en}
}
@article{ZhangChenSiemiatkowskaetal.2020,
  author    = {Zhang, Youjun and Chen, Moxian and Siemiatkowska, Beata and Toleco, Mitchell Rey and Jing, Yue and Strotmann, Vivien and Zhang, Jianghua and Stahl, Yvonne and Fernie, Alisdair R.},
  title     = {A highly efficient agrobacterium-mediated method for transient gene expression and functional studies in multiple plant species},
  series = {Plant Communications},
  volume    = {1},
  journal   = {Plant Communications},
  number    = {5},
  publisher = {Science Direct},
  address   = {New York},
  issn      = {2590-3462},
  pages     = {12},
  year      = {2020},
  abstract  = {Although the use of stable transformation technology has led to great insight into gene function, its application in high-throughput studies remains arduous. Agro-infiltration have been widely used in species such as Nicotiana benthamiana for the rapid detection of gene expression and protein interaction analysis, but this technique does not work efficiently in other plant species, including Arabidopsis thaliana. As an efficient high-throughput transient expression system is currently lacking in the model plant species A. thaliana, we developed a method that is characterized by high efficiency, reproducibility, and suitability for transient expression of a variety of functional proteins in A. thaliana and 7 other plant species, including Brassica oleracea, Capsella rubella, Thellungiella salsuginea, Thellungiella halophila, Solanum tuberosum, Capsicum annuum, and N. benthamiana. Efficiency of this method was independently verified in three independent research facilities, pointing to the robustness of this technique. Furthermore, in addition to demonstrating the utility of this technique in a range of species, we also present a case study employing this method to assess protein-protein interactions in the sucrose biosynthesis pathway in Arabidopsis.},
  language  = {en}
}
@article{SchwarzKutzinski2021,
  author    = {Schwarz, Ingo and Kutzinski, Vera M.},
  title     = {A Letter from Alexander von Humboldt to Joseph Albert Wright - Archival Traces},
  series = {HiN : Alexander von Humboldt im Netz},
  volume    = {XXII},
  journal   = {HiN : Alexander von Humboldt im Netz},
  number    = {43},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2568-3543},
  doi       = {10.25932/publishup-53278},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-532787},
  pages     = {5 -- 12},
  year      = {2021},
  abstract  = {A few months before his death, A. v. Humboldt attended the celebration in honor of the 127th birthday of George Washington at the US legation in Berlin. A letter to the American Envoy, Joseph A. Wright (1810 - 1867), underlines Humboldt's admiration for the fi rst president of the United States. At the same time Humboldt asked the diplomat to mail a letter to the German-American Bernard Moses (1832 - 1897) in Clinton, Louisiana, who had named his son Alexander Humboldt Moses (grave on the Hebrew Rest Cemetery \#2 in New Orleans, burial plot A, 12, 5). It appears to be possible that the Moses family still owns Humboldt's letter.},
  language  = {en}
}
@article{HeroldLabottGraessleretal.2022,
  author    = {Herold, Fabian and Labott, Berit K. and Gr{\"a}ssler, Bernhard and Halfpaap, Nicole and Langhans, Corinna and M{\"u}ller, Patrick and Ammar, Achraf and Dordevic, Milos and H{\"o}kelmann, Anita and M{\"u}ller, Notger Germar},
  title     = {A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls},
  series = {Healthcare : open access journal},
  volume    = {10},
  journal   = {Healthcare : open access journal},
  edition   = {2},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9032},
  doi       = {10.3390/healthcare10020230},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A\&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.},
  language  = {en}
}
@article{FuchsKoenigGerstenberg2021,
  author    = {Fuchs, Susanne and Koenig, Laura L. and Gerstenberg, Annette},
  title     = {A longitudinal study of speech acoustics in older French females},
  series = {Languages : open access journal},
  volume    = {6},
  journal   = {Languages : open access journal},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2226-471X},
  doi       = {10.3390/languages6040211},
  pages     = {24},
  year      = {2021},
  abstract  = {Aging in speech production is a multidimensional process. Biological, cognitive, social, and communicative factors can change over time, stay relatively stable, or may even compensate for each other. In this longitudinal work, we focus on stability and change at the laryngeal and supralaryngeal levels in the discourse particle euh produced by 10 older French-speaking females at two times, 10 years apart. Recognizing the multiple discourse roles of euh, we divided out occurrences according to utterance position. We quantified the frequency of euh, and evaluated acoustic changes in formants, fundamental frequency, and voice quality across time and utterance position. Results showed that euh frequency was stable with age. The only acoustic measure that revealed an age effect was harmonics-to-noise ratio, showing less noise at older ages. Other measures mostly varied with utterance position, sometimes in interaction with age. Some voice quality changes could reflect laryngeal adjustments that provide for airflow conservation utterance-finally. The data suggest that aging effects may be evident in some prosodic positions (e.g., utterance-final position), but not others (utterance-initial position). Thus, it is essential to consider the interactions among these factors in future work and not assume that vocal aging is evident throughout the signal.},
  language  = {en}
}
@article{MalemShinitskiOpperReichetal.2020,
  author    = {Malem-Shinitski, Noa and Opper, Manfred and Reich, Sebastian and Schwetlick, Lisa and Seelig, Stefan A. and Engbert, Ralf},
  title     = {A mathematical model of local and global attention in natural scene viewing},
  series = {PLoS Computational Biology : a new community journal},
  volume    = {16},
  journal   = {PLoS Computational Biology : a new community journal},
  number    = {12},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1553-734X},
  doi       = {10.1371/journal.pcbi.1007880},
  pages     = {21},
  year      = {2020},
  abstract  = {Author summary <br /> Switching between local and global attention is a general strategy in human information processing. We investigate whether this strategy is a viable approach to model sequences of fixations generated by a human observer in a free viewing task with natural scenes. Variants of the basic model are used to predict the experimental data based on Bayesian inference. Results indicate a high predictive power for both aggregated data and individual differences across observers. The combination of a novel model with state-of-the-art Bayesian methods lends support to our two-state model using local and global internal attention states for controlling eye movements. <br /> Understanding the decision process underlying gaze control is an important question in cognitive neuroscience with applications in diverse fields ranging from psychology to computer vision. The decision for choosing an upcoming saccade target can be framed as a selection process between two states: Should the observer further inspect the information near the current gaze position (local attention) or continue with exploration of other patches of the given scene (global attention)? Here we propose and investigate a mathematical model motivated by switching between these two attentional states during scene viewing. The model is derived from a minimal set of assumptions that generates realistic eye movement behavior. We implemented a Bayesian approach for model parameter inference based on the model's likelihood function. In order to simplify the inference, we applied data augmentation methods that allowed the use of conjugate priors and the construction of an efficient Gibbs sampler. This approach turned out to be numerically efficient and permitted fitting interindividual differences in saccade statistics. Thus, the main contribution of our modeling approach is two-fold; first, we propose a new model for saccade generation in scene viewing. Second, we demonstrate the use of novel methods from Bayesian inference in the field of scan path modeling.},
  language  = {en}
}
@article{HartungBorghardt2020,
  author    = {Hartung, Niklas and Borghardt, Jens Markus},
  title     = {A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs},
  series = {PLoS Computational Biology : a new community journal},
  volume    = {16},
  journal   = {PLoS Computational Biology : a new community journal},
  number    = {12},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1553-734X},
  doi       = {10.1371/journal.pcbi.1008466},
  pages     = {24},
  year      = {2020},
  abstract  = {Author summary <br /> The use of orally inhaled drugs for treating lung diseases is appealing since they have the potential for lung selectivity, i.e. high exposure at the site of action -the lung- without excessive side effects. However, the degree of lung selectivity depends on a large number of factors, including physiochemical properties of drug molecules, patient disease state, and inhalation devices. To predict the impact of these factors on drug exposure and thereby to understand the characteristics of an optimal drug for inhalation, we develop a predictive mathematical framework (a "pharmacokinetic model"). In contrast to previous approaches, our model allows combining knowledge from different sources appropriately and its predictions were able to adequately predict different sets of clinical data. Finally, we compare the impact of different factors and find that the most important factors are the size of the inhaled particles, the affinity of the drug to the lung tissue, as well as the rate of drug dissolution in the lung. In contrast to the common belief, the solubility of a drug in the lining fluids is not found to be relevant. These findings are important to understand how inhaled drugs should be designed to achieve best treatment results in patients. <br /> The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Even though each single process has been systematically investigated, a quantitative understanding on the interaction of processes remains limited and therefore identifying optimal drug and formulation characteristics for orally inhaled drugs is still challenging. To investigate this complex interplay, the pulmonary processes can be integrated into mathematical models. However, existing modeling attempts considerably simplify these processes or are not systematically evaluated against (clinical) data. In this work, we developed a mathematical framework based on physiologically-structured population equations to integrate all relevant pulmonary processes mechanistically. A tailored numerical resolution strategy was chosen and the mechanistic model was evaluated systematically against data from different clinical studies. Without adapting the mechanistic model or estimating kinetic parameters based on individual study data, the developed model was able to predict simultaneously (i) lung retention profiles of inhaled insoluble particles, (ii) particle size-dependent pharmacokinetics of inhaled monodisperse particles, (iii) pharmacokinetic differences between inhaled fluticasone propionate and budesonide, as well as (iv) pharmacokinetic differences between healthy volunteers and asthmatic patients. Finally, to identify the most impactful optimization criteria for orally inhaled drugs, the developed mechanistic model was applied to investigate the impact of input parameters on both the pulmonary and systemic exposure. Interestingly, the solubility of the inhaled drug did not have any relevant impact on the local and systemic pharmacokinetics. Instead, the pulmonary dissolution rate, the particle size, the tissue affinity, and the systemic clearance were the most impactful potential optimization parameters. In the future, the developed prediction framework should be considered a powerful tool for identifying optimal drug and formulation characteristics.},
  language  = {en}
}
@article{SchiroColangeliMueller2019,
  author    = {Schiro, Gabriele and Colangeli, Pierluigi and M{\"u}ller, Marina E. H.},
  title     = {A Metabarcoding Analysis of the Mycobiome of Wheat Ears Across a Topographically Heterogeneous Field},
  series = {Frontiers in microbiology},
  volume    = {10},
  journal   = {Frontiers in microbiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-302X},
  doi       = {10.3389/fmicb.2019.02095},
  pages     = {12},
  year      = {2019},
  language  = {en}
}
@article{StaubitzSerthThomasetal.2023,
  author    = {Staubitz, Thomas and Serth, Sebastian and Thomas, Max and Ebner, Martin and Koschutnig-Ebner, Markus and Rampelt, Florian and von Stetten, Alexander and Wittke, Andreas},
  title     = {A metastandard for the international exchange of MOOCs},
  series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?},
  journal   = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?},
  editor    = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  doi       = {10.25932/publishup-62415},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624154},
  pages     = {147 -- 161},
  year      = {2023},
  abstract  = {The MOOChub is a joined web-based catalog of all relevant German and Austrian MOOC platforms that lists well over 750 Massive Open Online Courses (MOOCs). Automatically building such a catalog requires that all partners describe and publicly offer the metadata of their courses in the same way. The paper at hand presents the genesis of the idea to establish a common metadata standard and the story of its subsequent development. The result of this effort is, first, an open-licensed de-facto-standard, which is based on existing commonly used standards and second, a first prototypical platform that is using this standard: the MOOChub, which lists all courses of the involved partners. This catalog is searchable and provides a more comprehensive overview of basically all MOOCs that are offered by German and Austrian MOOC platforms. Finally, the upcoming developments to further optimize the catalog and the metadata standard are reported.},
  language  = {en}
}
@article{RamezaniZiaraniBookhagenSchmidtetal.2021,
  author    = {Ramezani Ziarani, Maryam and Bookhagen, Bodo and Schmidt, Torsten and Wickert, Jens and de la Torre, Alejandro and Deng, Zhiguo and Calori, Andrea},
  title     = {A model for the relationship between rainfall, GNSS-derived integrated water vapour, and CAPE in the eastern central Andes},
  series = {Remote Sensing},
  volume    = {13},
  journal   = {Remote Sensing},
  number    = {18},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-4292},
  doi       = {10.3390/rs13183788},
  pages     = {19},
  year      = {2021},
  abstract  = {Atmospheric water vapour content is a key variable that controls the development of deep convective storms and rainfall extremes over the central Andes. Direct measurements of water vapour are challenging; however, recent developments in microwave processing allow the use of phase delays from L-band radar to measure the water vapour content throughout the atmosphere: Global Navigation Satellite System (GNSS)-based integrated water vapour (IWV) monitoring shows promising results to measure vertically integrated water vapour at high temporal resolutions. Previous works also identified convective available potential energy (CAPE) as a key climatic variable for the formation of deep convective storms and rainfall in the central Andes. Our analysis relies on GNSS data from the Argentine Continuous Satellite Monitoring Network, Red Argentina de Monitoreo Satelital Continuo (RAMSAC) network from 1999 to 2013. CAPE is derived from version 2.0 of the ECMWF's (European Centre for Medium-Range Weather Forecasts) Re-Analysis (ERA-interim) and rainfall from the TRMM (Tropical Rainfall Measuring Mission) product. In this study, we first analyse the rainfall characteristics of two GNSS-IWV stations by comparing their complementary cumulative distribution function (CCDF). Second, we separately derive the relation between rainfall vs. CAPE and GNSS-IWV. Based on our distribution fitting analysis, we observe an exponential relation of rainfall to GNSS-IWV. In contrast, we report a power-law relationship between the daily mean value of rainfall and CAPE at the GNSS-IWV station locations in the eastern central Andes that is close to the theoretical relationship based on parcel theory. Third, we generate a joint regression model through a multivariable regression analysis using CAPE and GNSS-IWV to explain the contribution of both variables in the presence of each other to extreme rainfall during the austral summer season. We found that rainfall can be characterised with a higher statistical significance for higher rainfall quantiles, e.g., the 0.9 quantile based on goodness-of-fit criterion for quantile regression. We observed different contributions of CAPE and GNSS-IWV to rainfall for each station for the 0.9 quantile. Fourth, we identify the temporal relation between extreme rainfall (the 90th, 95th, and 99th percentiles) and both GNSS-IWV and CAPE at 6 h time steps. We observed an increase before the rainfall event and at the time of peak rainfall—both for GNSS-integrated water vapour and CAPE. We show higher values of CAPE and GNSS-IWV for higher rainfall percentiles (99th and 95th percentiles) compared to the 90th percentile at a 6-h temporal scale. Based on our correlation analyses and the dynamics of the time series, we show that both GNSS-IWV and CAPE had comparable magnitudes, and we argue to consider both climatic variables when investigating their effect on rainfall extremes.},
  language  = {en}
}
@article{HassaninKliemSeehaferetal.2022,
  author    = {Hassanin, Alshaimaa and Kliem, Bernhard and Seehafer, Norbert and T{\"o}r{\"o}k, Tibor},
  title     = {A model of homologous confined and ejective eruptions involving kink instability and flux cancellation},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {929},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {2},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {2041-8205},
  doi       = {10.3847/2041-8213/ac64a9},
  pages     = {7},
  year      = {2022},
  abstract  = {In this study, we model a sequence of a confined and a full eruption, employing the relaxed end state of the confined eruption of a kink-unstable flux rope as the initial condition for the ejective one. The full eruption, a model of a coronal mass ejection, develops as a result of converging motions imposed at the photospheric boundary, which drive flux cancellation. In this process, parts of the positive and negative external flux converge toward the polarity inversion line, reconnect, and cancel each other. Flux of the same amount as the canceled flux transfers to a flux rope, increasing the free magnetic energy of the coronal field. With sustained flux cancellation and the associated progressive weakening of the magnetic tension of the overlying flux, we find that a flux reduction of approximate to 11\% initiates the torus instability of the flux rope, which leads to a full eruption. These results demonstrate that a homologous full eruption, following a confined one, can be driven by flux cancellation.},
  language  = {en}
}
@article{PornsawadSapsakulBoeckmann2019,
  author    = {Pornsawad, Pornsarp and Sapsakul, Nantawan and B{\"o}ckmann, Christine},
  title     = {A modified asymptotical regularization of nonlinear ill-posed problems},
  series = {Mathematics},
  volume    = {7},
  journal   = {Mathematics},
  edition   = {5},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-7390},
  doi       = {10.3390/math7050419},
  pages     = {19},
  year      = {2019},
  abstract  = {In this paper, we investigate the continuous version of modified iterative Runge-Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of ∥𝐹(𝑥𝛿(𝑇))-𝑦𝛿∥=𝜏𝛿+ for some 𝛿+>𝛿, and an appropriate source condition. We yield the optimal rate of convergence.},
  language  = {en}
}
@article{GrebenkovMetzlerOshanin2021,
  author    = {Grebenkov, Denis S. and Metzler, Ralf and Oshanin, Gleb},
  title     = {A molecular relay race: sequential first-passage events to the terminal reaction centre in a cascade of diffusion controlled processes},
  series = {New Journal of Physics (NJP)},
  volume    = {23},
  journal   = {New Journal of Physics (NJP)},
  publisher = {IOP - Institute of Physics Publishing},
  address   = {Bristol},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ac1e42},
  pages     = {18},
  year      = {2021},
  abstract  = {We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles. The model studied here represents a typical reaction setting encountered in diverse molecular biology systems, in which, e.g. a signal transduction proceeds via a series of consecutive 'messengers': the first messenger has to find its respective immobile target site triggering a launch of the second messenger, the second messenger seeks its own target site and provokes a launch of the third messenger and so on, resembling a relay race in human competitions. For such a molecular relay race taking place in infinite one-, two- and three-dimensional systems, we find exact expressions for the probability density function of the time instant of the terminal reaction event, conditioned on preceding successful reaction events on an ordered array of target sites. The obtained expressions pertain to the most general conditions: number of intermediate stages and the corresponding diffusion coefficients, the sizes of the target sites, the distances between them, as well as their reactivities are arbitrary.},
  language  = {en}
}
@article{PerachAlexandron2021,
  author    = {Perach, Shai and Alexandron, Giora},
  title     = {A MOOC-Based Computer Science Program for Middle School},
  series = {EMOOCs 2021},
  volume    = {2021},
  journal   = {EMOOCs 2021},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-512-5},
  doi       = {10.25932/publishup-51713},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-517133},
  pages     = {111 -- 127},
  year      = {2021},
  abstract  = {In an attempt to pave the way for more extensive Computer Science Education (CSE) coverage in K-12, this research developed and made a preliminary evaluation of a blended-learning Introduction to CS program based on an academic MOOC. Using an academic MOOC that is pedagogically effective and engaging, such a program may provide teachers with disciplinary scaffolds and allow them to focus their attention on enhancing students' learning experience and nurturing critical 21st-century skills such as self-regulated learning. As we demonstrate, this enabled us to introduce an academic level course to middle-school students. In this research, we developed the principals and initial version of such a program, targeting ninth-graders in science-track classes who learn CS as part of their standard curriculum. We found that the middle-schoolers who participated in the program achieved academic results on par with undergraduate students taking this MOOC for academic credit. Participating students also developed a more accurate perception of the essence of CS as a scientific discipline. The unplanned school closure due to the COVID19 pandemic outbreak challenged the research but underlined the advantages of such a MOOCbased blended learning program above classic pedagogy in times of global or local crises that lead to school closure. While most of the science track classes seem to stop learning CS almost entirely, and the end-of-year MoE exam was discarded, the program's classes smoothly moved to remote learning mode, and students continued to study at a pace similar to that experienced before the school shut down.},
  language  = {en}
}
@article{WinkelbeinerWandtEbertetal.2020,
  author    = {Winkelbeiner, Nicola Lisa and Wandt, Viktoria Klara Veronika and Ebert, Franziska and Lossow, Kristina and Bankoglu, Ezgi E. and Martin, Maximilian and Mangerich, Aswin and Stopper, Helga and Bornhorst, Julia and Kipp, Anna Patricia and Schwerdtle, Tanja},
  title     = {A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {18},
  publisher = {Molecular Diversity Preservation International},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21186600},
  pages     = {19},
  year      = {2020},
  abstract  = {Investigation of processes that contribute to the maintenance of genomic stability is one crucial factor in the attempt to understand mechanisms that facilitate ageing. The DNA damage response (DDR) and DNA repair mechanisms are crucial to safeguard the integrity of DNA and to prevent accumulation of persistent DNA damage. Among them, base excision repair (BER) plays a decisive role. BER is the major repair pathway for small oxidative base modifications and apurinic/apyrimidinic (AP) sites. We established a highly sensitive non-radioactive assay to measure BER incision activity in murine liver samples. Incision activity can be assessed towards the three DNA lesions 8-oxo-2'-deoxyguanosine (8-oxodG), 5-hydroxy-2'-deoxyuracil (5-OHdU), and an AP site analogue. We applied the established assay to murine livers of adult and old mice of both sexes. Furthermore, poly(ADP-ribosyl)ation (PARylation) was assessed, which is an important determinant in DDR and BER. Additionally, DNA damage levels were measured to examine the overall damage levels. No impact of ageing on the investigated endpoints in liver tissue were found. However, animal sex seems to be a significant impact factor, as evident by sex-dependent alterations in all endpoints investigated. Moreover, our results revealed interrelationships between the investigated endpoints indicative for the synergetic mode of action of the cellular DNA integrity maintaining machinery.},
  language  = {en}
}
@article{Brandenburger2022,
  author    = {Brandenburger, Bonny},
  title     = {A multidimensional and analytical perspective on Open Educational Practices in the 21st century},
  series = {Frontiers in education},
  volume    = {7},
  journal   = {Frontiers in education},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2504-284X},
  doi       = {10.3389/feduc.2022.990675},
  pages     = {17},
  year      = {2022},
  abstract  = {Participatory approaches to teaching and learning are experiencing a new lease on life in the 21st century as a result of the rapid technology development. Knowledge, practices, and tools can be shared across spatial and temporal boundaries in higher education by means of Open Educational Resources, Massive Open Online Courses, and open-source technologies. In this context, the Open Education Movement calls for new didactic approaches that encourage greater learner participation in formal higher education. Based on a representative literature review and focus group research, in this study an analytical framework was developed that enables researchers and practitioners to assess the form of participation in formal, collaborative teaching and learning practices. The analytical framework is focused on the micro-level of higher education, in particular on the interaction between students and lecturers when organizing the curriculum. For this purpose, the research reflects anew on the concept of participation, taking into account existing stage models for participation in the educational context. These are then brought together with the dimensions of teaching and learning processes, such as methods, objectives and content, etc. This paper aims to make a valuable contribution to the opening up of learning and teaching, and expands the discourse around possibilities for interpreting Open Educational Practices.},
  language  = {en}
}
@article{SchittkoBernardVerdierHegeretal.2020,
  author    = {Schittko, Conrad and Bernard-Verdier, Maud and Heger, Tina and Buchholz, Sascha and Kowarik, Ingo and von der Lippe, Moritz and Seitz, Birgit and Joshi, Jasmin Radha and Jeschke, Jonathan M.},
  title     = {A multidimensional framework for measuring biotic novelty: How novel is a community?},
  series = {Global Change Biology},
  volume    = {26},
  journal   = {Global Change Biology},
  number    = {8},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {New Jersey},
  pages     = {17},
  year      = {2020},
  abstract  = {Anthropogenic changes in climate, land use, and disturbance regimes, as well as introductions of non-native species can lead to the transformation of many ecosystems. The resulting novel ecosystems are usually characterized by species assemblages that have not occurred previously in a given area. Quantifying the ecological novelty of communities (i.e., biotic novelty) would enhance the understanding of environmental change. However, quantification remains challenging since current novelty metrics, such as the number and/or proportion of non-native species in a community, fall short of considering both functional and evolutionary aspects of biotic novelty. Here, we propose the Biotic Novelty Index (BNI), an intuitive and flexible multidimensional measure that combines (a) functional differences between native and non-native introduced species with (b) temporal dynamics of species introductions. We show that the BNI is an additive partition of Rao's quadratic entropy, capturing the novel interaction component of the community's functional diversity. Simulations show that the index varies predictably with the relative amount of functional novelty added by recently arrived species, and they illustrate the need to provide an additional standardized version of the index. We present a detailed R code and two applications of the BNI by (a) measuring changes of biotic novelty of dry grassland plant communities along an urbanization gradient in a metropolitan region and (b) determining the biotic novelty of plant species assemblages at a national scale. The results illustrate the applicability of the index across scales and its flexibility in the use of data of different quality. Both case studies revealed strong connections between biotic novelty and increasing urbanization, a measure of abiotic novelty. We conclude that the BNI framework may help building a basis for better understanding the ecological and evolutionary consequences of global change.},
  language  = {en}
}
@article{JannaschNickelBergmannetal.2022,
  author    = {Jannasch, Franziska and Nickel, Daniela V. and Bergmann, Manuela M. and Schulze, Matthias Bernd},
  title     = {A new evidence-based diet score to capture associations of food consumption and chronic disease risk},
  series = {Nutrients / Molecular Diversity Preservation International (MDPI)},
  volume    = {14},
  journal   = {Nutrients / Molecular Diversity Preservation International (MDPI)},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6643},
  doi       = {10.3390/nu14112359},
  pages     = {16},
  year      = {2022},
  abstract  = {Previously, the attempt to compile German dietary guidelines into a diet score was predominantly not successful with regards to preventing chronic diseases in the EPIC-Potsdam study. Current guidelines were supplemented by the latest evidence from systematic reviews and expert papers published between 2010 and 2020 on the prevention potential of food groups on chronic diseases such as type 2 diabetes, cardiovascular diseases and cancer. A diet score was developed by scoring the food groups according to a recommended low, moderate or high intake. The relative validity and reliability of the diet score, assessed by a food frequency questionnaire, was investigated. The consideration of current evidence resulted in 10 key food groups being preventive of the chronic diseases of interest. They served as components in the diet score and were scored from 0 to 1 point, depending on their recommended intake, resulting in a maximum of 10 points. Both the reliability (r = 0.53) and relative validity (r = 0.43) were deemed sufficient to consider the diet score as a stable construct in future investigations. This new diet score can be a promising tool to investigate dietary intake in etiological research by concentrating on 10 key dietary determinants with evidence-based prevention potential for chronic diseases.},
  language  = {en}
}
@article{ChengDennisOsuohaetal.2023,
  author    = {Cheng, Feng and Dennis, Alice B. and Osuoha, Josephine Ijeoma and Canitz, Julia and Kirschbaum, Frank and Tiedemann, Ralph},
  title     = {A new genome assembly of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha},
  series = {BMC genomics},
  volume    = {24},
  journal   = {BMC genomics},
  number    = {1},
  publisher = {BMC},
  address   = {London},
  issn      = {1471-2164},
  doi       = {10.1186/s12864-023-09196-6},
  pages     = {13},
  year      = {2023},
  abstract  = {Background Teleost fishes comprise more than half of the vertebrate species. Within teleosts, most phylogenies consider the split between Osteoglossomorpha and Euteleosteomorpha/Otomorpha as basal, preceded only by the derivation of the most primitive group of teleosts, the Elopomorpha. While Osteoglossomorpha are generally species poor, the taxon contains the African weakly electric fish (Mormyroidei), which have radiated into numerous species. Within the mormyrids, the genus Campylomormyrus is mostly endemic to the Congo Basin. Campylomormyrus serves as a model to understand mechanisms of adaptive radiation and ecological speciation, especially with regard to its highly diverse species-specific electric organ discharges (EOD). Currently, there are few well-annotated genomes available for electric fish in general and mormyrids in particular. Our study aims at producing a high-quality genome assembly and to use this to examine genome evolution in relation to other teleosts. This will facilitate further understanding of the evolution of the osteoglossomorpha fish in general and of electric fish in particular. Results A high-quality weakly electric fish (C. compressirostris) genome was produced from a single individual with a genome size of 862 Mb, consisting of 1,497 contigs with an N50 of 1,399 kb and a GC-content of 43.69\%. Gene predictions identified 34,492 protein-coding genes, which is a higher number than in the two other available Osteoglossomorpha genomes of Paramormyrops kingsleyae and Scleropages formosus. A Computational Analysis of gene Family Evolution (CAFE5) comparing 33 teleost fish genomes suggests an overall faster gene family turnover rate in Osteoglossomorpha than in Otomorpha and Euteleosteomorpha. Moreover, the ratios of expanded/contracted gene family numbers in Osteoglossomorpha are significantly higher than in the other two taxa, except for species that had undergone an additional genome duplication (Cyprinus carpio and Oncorhynchus mykiss). As potassium channel proteins are hypothesized to play a key role in EOD diversity among species, we put a special focus on them, and manually curated 16 Kv1 genes. We identified a tandem duplication in the KCNA7a gene in the genome of C. compressirostris. Conclusions We present the fourth genome of an electric fish and the third well-annotated genome for Osteoglossomorpha, enabling us to compare gene family evolution among major teleost lineages. Osteoglossomorpha appear to exhibit rapid gene family evolution, with more gene family expansions than contractions. The curated Kv1 gene family showed seven gene clusters, which is more than in other analyzed fish genomes outside Osteoglossomorpha. The KCNA7a, encoding for a potassium channel central for EOD production and modulation, is tandemly duplicated which may related to the diverse EOD observed among Campylomormyrus species.},
  language  = {en}
}
@article{VoitHeistermann2022,
  author    = {Voit, Paul and Heistermann, Maik},
  title     = {A new index to quantify the extremeness of precipitation across scales},
  series = {NHESS - Natural Hazards and Earth System Sciences},
  volume    = {22},
  journal   = {NHESS - Natural Hazards and Earth System Sciences},
  edition   = {8},
  publisher = {Copernicus},
  address   = {Katlenburg-Lindau},
  issn      = {1684-9981},
  doi       = {10.5194/nhess-22-2791-2022},
  pages     = {2791 -- 2805},
  year      = {2022},
  abstract  = {Quantifying the extremeness of heavy precipitation allows for the comparison of events. Conventional quantitative indices, however, typically neglect the spatial extent or the duration, while both are important to understand potential impacts. In 2014, the weather extremity index (WEI) was suggested to quantify the extremeness of an event and to identify the spatial and temporal scale at which the event was most extreme. However, the WEI does not account for the fact that one event can be extreme at various spatial and temporal scales. To better understand and detect the compound nature of precipitation events, we suggest complementing the original WEI with a "cross-scale weather extremity index" (xWEI), which integrates extremeness over relevant scales instead of determining its maximum. Based on a set of 101 extreme precipitation events in Germany, we outline and demonstrate the computation of both WEI and xWEI. We find that the choice of the index can lead to considerable differences in the assessment of past events but that the most extreme events are ranked consistently, independently of the index. Even then, the xWEI can reveal cross-scale properties which would otherwise remain hidden. This also applies to the disastrous event from July 2021, which clearly outranks all other analyzed events with regard to both WEI and xWEI. While demonstrating the added value of xWEI, we also identify various methodological challenges along the required computational workflow: these include the parameter estimation for the extreme value distributions, the definition of maximum spatial extent and temporal duration, and the weighting of extremeness at different scales. These challenges, however, also represent opportunities to adjust the retrieval of WEI and xWEI to specific user requirements and application scenarios.},
  language  = {en}
}
@article{ObbardShiRobertsetal.2020,
  author    = {Obbard, Darren J. and Shi, Mang and Roberts, Katherine E. and Longdon, Ben and Dennis, Alice B.},
  title     = {A new lineage of segmented RNA viruses infecting animals},
  series = {Virus Evolution},
  volume    = {6},
  journal   = {Virus Evolution},
  number    = {1},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {2057-1577},
  doi       = {10.1093/ve/vez061},
  pages     = {1 -- 10},
  year      = {2020},
  abstract  = {Metagenomic sequencing has revolutionised our knowledge of virus diversity, with new virus sequences being reported faster than ever before. However, virus discovery from metagenomic sequencing usually depends on detectable homology: without a sufficiently close relative, so-called 'dark' virus sequences remain unrecognisable. An alternative approach is to use virus-identification methods that do not depend on detecting homology, such as virus recognition by host antiviral immunity. For example, virus-derived small RNAs have previously been used to propose 'dark' virus sequences associated with the Drosophilidae (Diptera). Here, we combine published Drosophila data with a comprehensive search of transcriptomic sequences and selected meta-transcriptomic datasets to identify a completely new lineage of segmented positive-sense single-stranded RNA viruses that we provisionally refer to as the Quenyaviruses. Each of the five segments contains a single open reading frame, with most encoding proteins showing no detectable similarity to characterised viruses, and one sharing a small number of residues with the RNA-dependent RNA polymerases of single- and double-stranded RNA viruses. Using these sequences, we identify close relatives in approximately 20 arthropods, including insects, crustaceans, spiders, and a myriapod. Using a more conserved sequence from the putative polymerase, we further identify relatives in meta-transcriptomic datasets from gut, gill, and lung tissues of vertebrates, reflecting infections of vertebrates or of their associated parasites. Our data illustrate the utility of small RNAs to detect viruses with limited sequence conservation, and provide robust evidence for a new deeply divergent and phylogenetically distinct RNA virus lineage.},
  language  = {en}
}
@article{KindermannDoblerNiedeggenetal.2021,
  author    = {Kindermann, Liana and Dobler, Magnus and Niedeggen, Daniela and Linst{\"a}dter, Anja},
  title     = {A new protocol for estimation of woody aboveground biomass in disturbance-prone ecosystems},
  series = {Ecological indicators : integrating monitoring, assessment and management},
  volume    = {135},
  journal   = {Ecological indicators : integrating monitoring, assessment and management},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1470-160X},
  doi       = {10.1016/j.ecolind.2021.108466},
  pages     = {16},
  year      = {2021},
  abstract  = {Almost one third of global drylands are open forests and savannas, which are typically shaped by frequent natural disturbances such as wildfire and herbivory. Studies on ecosystem functions and services of woody vegetation require robust estimates of aboveground biomass (AGB). However, most methods have been developed for comparatively undisturbed forest ecosystems. As they are not tailored to accurately quantify AGB of small and irregular growth forms, their application on these growth forms may lead to unreliable or even biased AGB estimates in disturbance-prone dryland ecosystems. Moreover, these methods cannot quantify AGB losses caused by disturbance agents. Here we propose a methodology to estimate individual-and stand-level woody AGB in disturbance-prone ecosystems. It consists of flexible field sampling routines and estimation workflows for six growth classes, delineated by size and damage criteria. It also comprises a detailed damage assessment, harnessing the ecological archive of woody growth for past disturbances. Based on large inventories collected along steep gradients of elephant disturbances in African dryland ecosystems, we compared the AGB estimates generated with our proposed method against estimates from a less adapted forest inventory method. We evaluated the necessary stepwise procedures of method adaptation and analyzed each step's effect on stand-level AGB estimation. We further explored additional advantages of our proposed method with regard to disturbance impact quantification. Results indicate that a majority of growth forms and individuals in savanna vegetation could only be assessed if methods of AGB estimation were adapted to the conditions of a disturbance-prone ecosystem. Furthermore, our damage assessment demonstrated that one third to half of all woody AGB was lost to disturbances. Consequently, less adapted methods may be insufficient and are likely to render inaccurate AGB estimations. Our proposed method has the potential to accurately quantify woody AGB in disturbance-prone ecosystems, as well as AGB losses. Our method is more time consuming than conventional allometric approaches, yet it can cover sufficient areas within reasonable timespans, and can also be easily adapted to alternative sampling schemes.},
  language  = {en}
}
@article{SrokaGodunkoRutschmannetal.2019,
  author    = {Sroka, Pavel and Godunko, Roman J. and Rutschmann, Sereina and Angeli, Kamila B. and Salles, Frederico F. and Gattolliat, Jean-Luc},
  title     = {A new species of Bungona in Turkey (Ephemeroptera, Baetidae)},
  series = {Zoosytematics and evolution},
  volume    = {95},
  journal   = {Zoosytematics and evolution},
  number    = {1},
  publisher = {Pensoft Publ.},
  address   = {Sofia},
  issn      = {1860-0743},
  doi       = {10.3897/zse.95.29487},
  pages     = {1 -- 13},
  year      = {2019},
  abstract  = {By using an integrative approach, we describe a new species of mayfly, Bungona (Chopralla) pontica sp. n., from Turkey. The discovery of a representative of the tropical mayfly genus Bungona in the Middle East is rather unexpected. The new species shows all the main morphological characters of the subgenus Chopralla, which has its closest related species occurring in southeastern Asia. Barcoding clearly indicated that the new species represents an independent lineage isolated for a very long time from other members of the complex. The claw is equipped with two rows of three or four flattened denticles. This condition is a unique feature of Bungona (Chopralla) pontica sp. n. among West Palaearctic mayfly species. Within the subgenus Chopralla, the species can be identified by the presence of a simple, not bifid right prostheca (also present only in Bungona (Chopralla) liebenauae (Soldan, Braasch \& Muu, 1987)), the shape of the labial palp, and the absence of protuberances on pronotum.},
  language  = {en}
}
@article{GoethelListekMesserschmidtetal.2021,
  author    = {G{\"o}thel, Markus and Listek, Martin and Messerschmidt, Katrin and Schl{\"o}r, Anja and H{\"o}now, Anja and Hanack, Katja},
  title     = {A New Workflow to Generate Monoclonal Antibodies against Microorganisms},
  series = {Applied Sciences},
  volume    = {11},
  journal   = {Applied Sciences},
  number    = {20},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1454-5101},
  doi       = {10.3390/app11209359},
  pages     = {15},
  year      = {2021},
  abstract  = {Monoclonal antibodies are used worldwide as highly potent and efficient detection reagents for research and diagnostic applications. Nevertheless, the specific targeting of complex antigens such as whole microorganisms remains a challenge. To provide a comprehensive workflow, we combined bioinformatic analyses with novel immunization and selection tools to design monoclonal antibodies for the detection of whole microorganisms. In our initial study, we used the human pathogenic strain E. coli O157:H7 as a model target and identified 53 potential protein candidates by using reverse vaccinology methodology. Five different peptide epitopes were selected for immunization using epitope-engineered viral proteins. The identification of antibody-producing hybridomas was performed by using a novel screening technology based on transgenic fusion cell lines. Using an artificial cell surface receptor expressed by all hybridomas, the desired antigen-specific cells can be sorted fast and efficiently out of the fusion cell pool. Selected antibody candidates were characterized and showed strong binding to the target strain E. coli O157:H7 with minor or no cross-reactivity to other relevant microorganisms such as Legionella pneumophila and Bacillus ssp. This approach could be useful as a highly efficient workflow for the generation of antibodies against microorganisms.},
  language  = {en}
}
@article{WoutersenJardineGiovanniBogotaAngeletal.2018,
  author    = {Woutersen, Amber and Jardine, Phillip E. and Giovanni Bogota-Angel, Raul and Zhang, Hong-Xiang and Silvestro, Daniele and Antonelli, Alexandre and Gogna, Elena and Erkens, Roy H. J. and Gosling, William D. and Dupont-Nivet, Guillaume and Hoorn, Carina},
  title     = {A novel approach to study the morphology and chemistry of pollen in a phylogenetic context, applied to the halophytic taxon Nitraria L.(Nitrariaceae)},
  series = {PeerJ},
  volume    = {6},
  journal   = {PeerJ},
  publisher = {PeerJ Inc.},
  address   = {London},
  issn      = {2167-8359},
  doi       = {10.7717/peerj.5055},
  pages     = {31},
  year      = {2018},
  abstract  = {Nitraria is a halophytic taxon (i.e., adapted to saline environments) that belongs to the plant family Nitrariaceae and is distributed from the Mediterranean, across Asia into the south-eastern tip of Australia. This taxon is thought to have originated in Asia during the Paleogene (66-23 Ma), alongside the proto-Paratethys epicontinental sea. The evolutionary history of Nitraria might hold important clues on the links between climatic and biotic evolution but limited taxonomic documentation of this taxon has thus far hindered this line of research. Here we investigate if the pollen morphology and the chemical composition of the pollen wall are informative of the evolutionary history of Nitraria and could explain if origination along the proto-Paratethys and dispersal to the Tibetan Plateau was simultaneous or a secondary process. To answer these questions, we applied a novel approach consisting of a combination of Fourier Transform Infrared spectroscopy (FTIR), to determine the chemical composition of the pollen wall, and pollen morphological analyses using Light Microscopy (LM) and Scanning Electron Microscopy (SEM). We analysed our data using ordinations (principal components analysis and non-metric multidimensional scaling), and directly mapped it on the Nitrariaceae phylogeny to produce a phylomorphospace and a phylochemospace. Our LM, SEM and FTIR analyses show clear morphological and chemical differences between the sister groups Peganum and Nitraria. Differences in the morphological and chemical characteristics of highland species (Nitraria schoberi, N. sphaerocarpa, N. sibirica and N. tangutorum) and lowland species (Nitraria billardierei and N. retusa) are very subtle, with phylogenetic history appearing to be a more important control on Nitraria pollen than local environmental conditions. Our approach shows a compelling consistency between the chemical and morphological characteristics of the eight studied Nitrariaceae species, and these traits are in agreement with the phylogenetic tree. Taken together, this demonstrates how novel methods for studying fossil pollen can facilitate the evolutionary investigation of living and extinct taxa, and the environments they represent.},
  language  = {en}
}
@article{KagelBierFrohmeetal.2019,
  author    = {Kagel, Heike and Bier, Frank Fabian and Frohme, Marcus and Gl{\"o}kler, J{\"o}rn F.},
  title     = {A Novel Optical Method To Reversibly Control Enzymatic Activity Based On Photoacids},
  series = {Scientific reports},
  volume    = {9},
  journal   = {Scientific reports},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-019-50867-w},
  pages     = {6},
  year      = {2019},
  abstract  = {Most biochemical reactions depend on the pH value of the aqueous environment and some are strongly favoured to occur in an acidic environment. A non-invasive control of pH to tightly regulate such reactions with defined start and end points is a highly desirable feature in certain applications, but has proven difficult to achieve so far. We report a novel optical approach to reversibly control a typical biochemical reaction by changing the pH and using acid phosphatase as a model enzyme. The reversible photoacid G-acid functions as a proton donor, changing the pH rapidly and reversibly by using high power UV LEDs as an illumination source in our experimental setup. The reaction can be tightly controlled by simply switching the light on and off and should be applicable to a wide range of other enzymatic reactions, thus enabling miniaturization and parallelization through non-invasive optical means.},
  language  = {en}
}
@article{WehrhanSommer2021,
  author    = {Wehrhan, Marc and Sommer, Michael},
  title     = {A parsimonious approach to estimate soil organic carbon applying Unmanned Aerial System (UAS) multispectral imagery and the topographic position index in a heterogeneous soil landscape},
  series = {Remote sensing / Molecular Diversity Preservation International (MDPI)},
  volume    = {13},
  journal   = {Remote sensing / Molecular Diversity Preservation International (MDPI)},
  number    = {18},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-4292},
  doi       = {10.3390/rs13183557},
  pages     = {20},
  year      = {2021},
  abstract  = {Remote sensing plays an increasingly key role in the determination of soil organic carbon (SOC) stored in agriculturally managed topsoils at the regional and field scales. Contemporary Unmanned Aerial Systems (UAS) carrying low-cost and lightweight multispectral sensors provide high spatial resolution imagery (<10 cm). These capabilities allow integrate of UAS-derived soil data and maps into digitalized workflows for sustainable agriculture. However, the common situation of scarce soil data at field scale might be an obstacle for accurate digital soil mapping. In our case study we tested a fixed-wing UAS equipped with visible and near infrared (VIS-NIR) sensors to estimate topsoil SOC distribution at two fields under the constraint of limited sampling points, which were selected by pedological knowledge. They represent all releva nt soil types along an erosion-deposition gradient; hence, the full feature space in terms of topsoils' SOC status. We included the Topographic Position Index (TPI) as a co-variate for SOC prediction. Our study was performed in a soil landscape of hummocky ground moraines, which represent a significant of global arable land. Herein, small scale soil variability is mainly driven by tillage erosion which, in turn, is strongly dependent on topography. Relationships between SOC, TPI and spectral information were tested by Multiple Linear Regression (MLR) using: (i) single field data (local approach) and (ii) data from both fields (pooled approach). The highest prediction performance determined by a leave-one-out-cross-validation (LOOCV) was obtained for the models using the reflectance at 570 nm in conjunction with the TPI as explanatory variables for the local approach (coefficient of determination (R-2) = 0.91; root mean square error (RMSE) = 0.11\% and R-2 = 0.48; RMSE = 0.33, respectively). The local MLR models developed with both reflectance and TPI using values from all points showed high correlations and low prediction errors for SOC content (R-2 = 0.88, RMSE = 0.07\%; R-2 = 0.79, RMSE = 0.06\%, respectively). The comparison with an enlarged dataset consisting of all points from both fields (pooled approach) showed no improvement of the prediction accuracy but yielded decreased prediction errors. Lastly, the local MLR models were applied to the data of the respective other field to evaluate the cross-field prediction ability. The spatial SOC pattern generally remains unaffected on both fields; differences, however, occur concerning the predicted SOC level. Our results indicate a high potential of the combination of UAS-based remote sensing and environmental covariates, such as terrain attributes, for the prediction of topsoil SOC content at the field scale. The temporal flexibility of UAS offer the opportunity to optimize flight conditions including weather and soil surface status (plant cover or residuals, moisture and roughness) which, otherwise, might obscure the relationship between spectral data and SOC content. Pedologically targeted selection of soil samples for model development appears to be the key for an efficient and effective prediction even with a small dataset.},
  language  = {en}
}
@article{GrossmannAransonPeruani2020,
  author    = {Großmann, Robert and Aranson, Igor S. and Peruani, Fernando},
  title     = {A particle-field approach bridges phase separation and collective motion in active matter},
  series = {Nature Communications},
  volume    = {11},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-020-18978-5},
  pages     = {12},
  year      = {2020},
  abstract  = {Whereas self-propelled hard discs undergo motility-induced phase separation, self-propelled rods exhibit a variety of nonequilibrium phenomena, including clustering, collective motion, and spatio-temporal chaos. In this work, we present a theoretical framework representing active particles by continuum fields. This concept combines the simplicity of alignment-based models, enabling analytical studies, and realistic models that incorporate the shape of self-propelled objects explicitly. By varying particle shape from circular to ellipsoidal, we show how nonequilibrium stresses acting among self-propelled rods destabilize motility-induced phase separation and facilitate orientational ordering, thereby connecting the realms of scalar and vectorial active matter. Though the interaction potential is strictly apolar, both, polar and nematic order may emerge and even coexist. Accordingly, the symmetry of ordered states is a dynamical property in active matter. The presented framework may represent various systems including bacterial colonies, cytoskeletal extracts, or shaken granular media. Interacting self-propelled particles exhibit phase separation or collective motion depending on particle shape. A unified theory connecting these paradigms represents a major challenge in active matter, which the authors address here by modeling active particles as continuum fields.},
  language  = {en}
}
@article{MalassTarkhanov2020,
  author    = {Malass, Ihsane and Tarkhanov, Nikolaj Nikolaevič},
  title     = {A perturbation of the de Rham complex},
  series = {Journal of Siberian Federal University : Mathematics \& Physics},
  volume    = {13},
  journal   = {Journal of Siberian Federal University : Mathematics \& Physics},
  number    = {5},
  publisher = {Siberian Federal University},
  address   = {Krasnojarsk},
  issn      = {1997-1397},
  doi       = {10.17516/1997-1397-2020-13-5-519-532},
  pages     = {519 -- 532},
  year      = {2020},
  abstract  = {We consider a perturbation of the de Rham complex on a compact manifold with boundary. This perturbation goes beyond the framework of complexes, and so cohomology does not apply to it. On the other hand, its curvature is "small", hence there is a natural way to introduce an Euler characteristic and develop a Lefschetz theory for the perturbation. This work is intended as an attempt to develop a cohomology theory for arbitrary sequences of linear mappings.},
  language  = {en}
}
@article{SpikesRodriguezSilvaBennettetal.2021,
  author    = {Spikes, Montrai and Rodr{\´i}guez-Silva, Rodet and Bennett, Kerri-Ann and Br{\"a}ger, Stefan and Josaphat, James and Torres-Pineda, Patricia and Ernst, Anja and Havenstein, Katja and Schlupp, Ingo and Tiedemann, Ralph},
  title     = {A phylogeny of the genus Limia (Teleostei: Poeciliidae) suggests a single-lake radiation nested in a Caribbean-wide allopatric speciation scenario},
  series = {BMC Research Notes},
  volume    = {14},
  journal   = {BMC Research Notes},
  publisher = {BMC Research Notes / Biomed Central},
  address   = {London},
  issn      = {1756-0500},
  doi       = {10.1186/s13104-021-05843-x},
  pages     = {1 -- 8},
  year      = {2021},
  abstract  = {Objective The Caribbean is an important global biodiversity hotspot. Adaptive radiations there lead to many speciation events within a limited period and hence are particularly prominent biodiversity generators. A prime example are freshwater fish of the genus Limia, endemic to the Greater Antilles. Within Hispaniola, nine species have been described from a single isolated site, Lake Mirago{\^a}ne, pointing towards extraordinary sympatric speciation. This study examines the evolutionary history of the Limia species in Lake Mirago{\^a}ne, relative to their congeners throughout the Caribbean. Results For 12 Limia species, we obtained almost complete sequences of the mitochondrial cytochrome b gene, a well-established marker for lower-level taxonomic relationships. We included sequences of six further Limia species from GenBank (total N  = 18 species). Our phylogenies are in concordance with other published phylogenies of Limia. There is strong support that the species found in Lake Mirago{\^a}ne in Haiti are monophyletic, confirming a recent local radiation. Within Lake Mirago{\^a}ne, speciation is likely extremely recent, leading to incomplete lineage sorting in the mtDNA. Future studies using multiple unlinked genetic markers are needed to disentangle the relationships within the Lake Mirago{\^a}ne clade.},
  language  = {en}
}
@article{HintscheWaljorGrossmannetal.2017,
  author    = {Hintsche, Marius and Waljor, Veronika and Grossmann, Robert and K{\"u}hn, Marco J. and Thormann, Kai M. and Peruani, Fernando and Beta, Carsten},
  title     = {A polar bundle of flagella can drive bacterial swimming by pushing, pulling, or coiling around the cell body},
  series = {Scientific reports},
  volume    = {7},
  journal   = {Scientific reports},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-16428-9},
  pages     = {10},
  year      = {2017},
  abstract  = {Bacteria swim in sequences of straight runs that are interrupted by turning events. They drive their swimming locomotion with the help of rotating helical flagella. Depending on the number of flagella and their arrangement across the cell body, different run-and-turn patterns can be observed. Here, we present fluorescence microscopy recordings showing that cells of the soil bacterium Pseudomonas putida that are decorated with a polar tuft of helical flagella, can alternate between two distinct swimming patterns. On the one hand, they can undergo a classical push-pull-push cycle that is well known from monopolarly flagellated bacteria but has not been reported for species with a polar bundle of multiple flagella. Alternatively, upon leaving the pulling mode, they can enter a third slow swimming phase, where they propel themselves with their helical bundle wrapped around the cell body. A theoretical estimate based on a random-walk model shows that the spreading of a population of swimmers is strongly enhanced when cycling through a sequence of pushing, pulling, and wrapped flagellar configurations as compared to the simple push-pull-push pattern.},
  language  = {en}
}
@article{Paessler2017,
  author    = {P{\"a}ßler, Ulrich},
  title     = {A Political Economy of Nature},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XVIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {34},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.18443/252},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395781},
  pages     = {80 -- 91},
  year      = {2017},
  abstract  = {In seinem Aufsatz „Ueber die Schwankungen der Goldproduktion mit R{\"u}cksicht auf staatswirthschaftliche Probleme" (1838) entfaltet Alexander von Humboldt auf wenigen Seiten eine Weltgeschichte des Edelmetallverkehrs von der Antike bis ins 19. Jahrhundert. Der vorliegende Artikel geht Humboldts {\"o}konomischem Denken als Teil seiner Forschungen zur Natur- und Menschheitsgeschichte nach. Er beginnt mit einem kurzen Abriss der von sp{\"a}tmerkantilistischen und fr{\"u}hliberalen Einfl{\"u}ssen gepr{\"a}gten Ausbildung Humboldts. Der Artikel diskutiert anschließend eine von Humboldt angefertigte Weltkarte sowie vier darauf bezogene Schaubilder, die historische und zeitgen{\"o}ssische statistische Daten zur graphischen Vision eines globalen Wirtschaftskreislaufs kombinieren. In einem weiteren Schritt geht der Artikel Humboldts Anwendung historischer und naturgeschichtlicher Forschungsmethoden auf dem Gebiet der politischen {\"O}konomie am Beispiel des Aufsatzes von 1838 nach. Den Schluss der Untersuchung bildet Humboldts Auseinandersetzung mit dem Edelmetall Platin, dessen begrenzte Verbreitung im Widerspruch zur Idee eines freien weltweiten Austauschs stand.},
  language  = {en}
}
@article{WarschburgerKamrathLanzingeretal.2023,
  author    = {Warschburger, Petra and Kamrath, Clemens and Lanzinger, Stefanie and Sengler, Claudia and Wiegand, Susanna and G{\"o}ldel, Julia Marlen and Weihrauch-Bl{\"u}her, Susann and Holl, Reinhard and Minden, Kirsten},
  title     = {A prospective analysis of the long-term impact of the COVID-19 pandemic on well-being and health care among children with a chronic condition and their families},
  series = {BMC pediatrics},
  volume    = {23},
  journal   = {BMC pediatrics},
  number    = {1},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1471-2431},
  doi       = {10.1186/s12887-023-03912-7},
  pages     = {15},
  year      = {2023},
  abstract  = {Background There is consistent evidence that the COVID-19 pandemic is associated with an increased psychosocial burden on children and adolescents and their parents. Relatively little is known about its particular impact on high-risk groups with chronic physical health conditions (CCs). Therefore, the primary aim of the study is to analyze the multiple impacts on health care and psychosocial well-being on these children and adolescents and their parents. Methods We will implement a two-stage approach. In the first step, parents and their underage children from three German patient registries for diabetes, obesity, and rheumatic diseases, are invited to fill out short questionnaires including questions about corona-specific stressors, the health care situation, and psychosocial well-being. In the next step, a more comprehensive, in-depth online survey is carried out in a smaller subsample. Discussion The study will provide insights into the multiple longer-term stressors during the COVID-19 pandemic in families with a child with a CC. The simultaneous consideration of medical and psycho-social endpoints will help to gain a deeper understanding of the complex interactions affecting family functioning, psychological well-being, and health care delivery.},
  language  = {en}
}
@article{WarschburgerPetersenvonRezorietal.2021,
  author    = {Warschburger, Petra and Petersen, Ann-Christin and von Rezori, Roman Enzio and Buchallik, Friederike and Baumeister, Harald and Holl, Reinhard and Minden, Kirsten and M{\"u}ller-​Stierlin, Annabel Sandra and Reinauer, Christina and Staab, Doris and COACH consortium,},
  title     = {A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study},
  series = {BMC Pediatrics},
  volume    = {21},
  journal   = {BMC Pediatrics},
  publisher = {BMC pediatrics},
  address   = {London},
  issn      = {1471-2431},
  doi       = {10.1186/s12887-021-02869-9},
  pages     = {1 -- 13},
  year      = {2021},
  abstract  = {Background Relatively little is known about protective factors and the emergence and maintenance of positive outcomes in the field of adolescents with chronic conditions. Therefore, the primary aim of the study is to acquire a deeper understanding of the dynamic process of resilience factors, coping strategies and psychosocial adjustment of adolescents living with chronic conditions. Methods/design We plan to consecutively recruit N = 450 adolescents (12-21 years) from three German patient registries for chronic conditions (type 1 diabetes, cystic fibrosis, or juvenile idiopathic arthritis). Based on screening for anxiety and depression, adolescents are assigned to two parallel groups - "inconspicuous" (PHQ-9 and GAD-7 < 7) vs. "conspicuous" (PHQ-9 or GAD-7 ≥ 7) - participating in a prospective online survey at baseline and 12-month follow-up. At two time points (T1, T2), we assess (1) intra- and interpersonal resiliency factors, (2) coping strategies, and (3) health-related quality of life, well-being, satisfaction with life, anxiety and depression. Using a cross-lagged panel design, we will examine the bidirectional longitudinal relations between resiliency factors and coping strategies, psychological adaptation, and psychosocial adjustment. To monitor Covid-19 pandemic effects, participants are also invited to take part in an intermediate online survey. Discussion The study will provide a deeper understanding of adaptive, potentially modifiable processes and will therefore help to develop novel, tailored interventions supporting a positive adaptation in youths with a chronic condition. These strategies should not only support those at risk but also promote the maintenance of a successful adaptation. Trial registration German Clinical Trials Register (DRKS), no. DRKS00025125. Registered on May 17, 2021.},
  language  = {en}
}
@article{HeimannVasyuraBathkeSudhausetal.2019,
  author    = {Heimann, Sebastian and Vasyura-Bathke, Hannes and Sudhaus, Henriette and Isken, Marius Paul and Kriegerowski, Marius and Steinberg, Andreas and Dahm, Torsten},
  title     = {A Python framework for efficient use of pre-computed Green's functions in seismological and other physical forward and inverse source problems},
  series = {Solid earth},
  volume    = {10},
  journal   = {Solid earth},
  number    = {6},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1869-9510},
  doi       = {10.5194/se-10-1921-2019},
  pages     = {1921 -- 1935},
  year      = {2019},
  abstract  = {The computation of such synthetic GFs is computationally and operationally demanding. As a consequence, the onthe-fly recalculation of synthetic GFs in each iteration of an optimisation is time-consuming and impractical. Therefore, the pre-calculation and efficient storage of synthetic GFs on a dense grid of source to receiver combinations enables the efficient lookup and utilisation of GFs in time-critical scenarios. We present a Python-based framework and toolkit - Pyrocko-GF - that enables the pre-calculation of synthetic GF stores, which are independent of their numerical calculation method and GF transfer function. The framework aids in the creation of such GF stores by interfacing a suite of established numerical forward modelling codes in seismology (computational back ends). So far, interfaces to back ends for layered Earth model cases have been provided; however, the architecture of Pyrocko-GF is designed to cover back ends for other geometries (e.g. full 3-D heterogeneous media) and other physical quantities (e.g. gravity, pressure, tilt). Therefore, Pyrocko-GF defines an extensible GF storage format suitable for a wide range of GF types, especially handling elasticity and wave propagation problems. The framework assists with visualisations, quality control, and the exchange of GF stores, which is supported through an online platform that provides many pre-calculated GF stores for local, regional, and global studies. The Pyrocko-GF toolkit comes with a well-documented application programming interface (API) for the Python programming language to efficiently facilitate forward modelling of geophysical processes, e.g. synthetic waveforms or static displacements for a wide range of source models.},
  language  = {en}
}
@article{ShlakaOuahibBerrada2023,
  author    = {Shlaka, Souhad and Ouahib, Sara and Berrada, Khalid},
  title     = {A retrospective feedback of MOOCS in Morocco},
  series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?},
  journal   = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?},
  editor    = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  doi       = {10.25932/publishup-62482},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624826},
  pages     = {317 -- 327},
  year      = {2023},
  abstract  = {The integration of MOOCs into the Moroccan Higher Education (MHE) took place in 2013 by developing different partnerships and projects at national and international levels. As elsewhere, the Covid-19 crisis has played an important role in accelerating distance education in MHE. However, based on our experience as both university professors and specialists in educational engineering, the effective execution of the digital transition has not yet been implemented. Thus, in this article, we present a retrospective feedback of MOOCs in Morocco, focusing on the policies taken by the government to better support the digital transition in general and MOOCs in particular. We are therefore seeking to establish an optimal scenario for the promotion of MOOCs, which emphasizes the policies to be considered, and which recalls the importance of conducting a delicate articulation taking into account four levels, namely environmental, institutional, organizational and individual. We conclude with recommendations that are inspired by the Moroccan academic contex that focus on the major role that MOOCs plays for university students and on maintaining lifelong learning.},
  language  = {en}
}
@article{KuehnHainzlDahmetal.2022,
  author    = {K{\"u}hn, Daniela and Hainzl, Sebastian and Dahm, Torsten and Richter, Gudrun and Vera Rodriguez, Ismael},
  title     = {A review of source models to further the understanding of the seismicity of the Groningen field},
  series = {Netherlands journal of geosciences : NJG},
  volume    = {101},
  journal   = {Netherlands journal of geosciences : NJG},
  publisher = {Cambridge Univ. Press},
  address   = {Cambridge},
  issn      = {0016-7746},
  doi       = {10.1017/njg.2022.7},
  pages     = {12},
  year      = {2022},
  abstract  = {The occurrence of felt earthquakes due to gas production in Groningen has initiated numerous studies and model attempts to understand and quantify induced seismicity in this region. The whole bandwidth of available models spans the range from fully deterministic models to purely empirical and stochastic models. In this article, we summarise the most important model approaches, describing their main achievements and limitations. In addition, we discuss remaining open questions and potential future directions of development.},
  language  = {en}
}
@article{SolgerKunzFinketal.2019,
  author    = {Solger, Franziska and Kunz, Tobias C. and Fink, Julian and Paprotka, Kerstin and Pfister, Pauline and Hagen, Franziska and Schumacher, Fabian and Kleuser, Burkhard and Seibel, J{\"u}rgen and Rudel, Thomas},
  title     = {A role of sphingosine in the intracellular survival of Neisseria gonorrhoeae},
  series = {Frontiers in Cellular and Infection Microbiology},
  volume    = {10},
  journal   = {Frontiers in Cellular and Infection Microbiology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2235-2988},
  doi       = {10.3389/fcimb.2020.00215},
  pages     = {12},
  year      = {2019},
  abstract  = {Obligate human pathogenic Neisseria gonorrhoeae are the second most frequent bacterial cause of sexually transmitted diseases. These bacteria invade different mucosal tissues and occasionally disseminate into the bloodstream. Invasion into epithelial cells requires the activation of host cell receptors by the formation of ceramide-rich platforms. Here, we investigated the role of sphingosine in the invasion and intracellular survival of gonococci. Sphingosine exhibited an anti-gonococcal activity in vitro. We used specific sphingosine analogs and click chemistry to visualize sphingosine in infected cells. Sphingosine localized to the membrane of intracellular gonococci. Inhibitor studies and the application of a sphingosine derivative indicated that increased sphingosine levels reduced the intracellular survival of gonococci. We demonstrate here, that sphingosine can target intracellular bacteria and may therefore exert a direct bactericidal effect inside cells.},
  language  = {en}
}
@article{Grewing2020,
  author    = {Grewing, Farouk F.},
  title     = {A Saturnalian poet as a literary critic},
  series = {thersites = tessellae - Birthday Issue for Christine Walde},
  volume    = {2020},
  journal   = {thersites = tessellae - Birthday Issue for Christine Walde},
  number    = {11},
  editor    = {Amb{\"u}hl, Annemarie},
  issn      = {2364-7612},
  doi       = {10.34679/thersites.vol11.170},
  pages     = {176 -- 204},
  year      = {2020},
  abstract  = {This paper analyzes a specific section of Martial's Apophoreta (Book 14), the 'list' of fourteen literary works that the poet-persona suggests to the reader as potentially suitable presents to give to friends on the occasion of the Saturnalia. It focuses strictly on the literary aspects of the poems and their underlying carnivalesque poetics. This includes an assessment of the logic of the poems' arrangement and alleged inconsistencies. It is suggested that the section be read as a complex statement of Martial's on various works and genres of Greek and Roman literature. The last couplet of the section (14.196), a certain Calvus' work 'On the use of cold water' (De aquae frigidae usu), which is unidentifiable, receives particular attention, for previous scholarship has wasted a lot of ink on guessing what kind of work this may have been, thereby losing touch with the rich (meta-)poetics the couplet actually conveys.},
  language  = {en}
}
@article{Buerger2019,
  author    = {B{\"u}rger, Gerd},
  title     = {A seamless filter for daily to seasonal forecasts, with applications to Iran and Brazil},
  series = {Quarterly Journal of the Royal Meteorological Society},
  volume    = {146},
  journal   = {Quarterly Journal of the Royal Meteorological Society},
  number    = {726},
  publisher = {WILEY-VCH},
  address   = {Weinheim},
  pages     = {14},
  year      = {2019},
  abstract  = {A digital filter is introduced which treats the problem of predictability versus time averaging in a continuous, seamless manner. This seamless filter (SF) is characterized by a unique smoothing rule that determines the strength of smoothing in dependence on lead time. The rule needs to be specified beforehand, either by expert knowledge or by user demand. As a result, skill curves are obtained that allow a predictability assessment across a whole range of time-scales, from daily to seasonal, in a uniform manner. The SF is applied to downscaled SEAS5 ensemble forecasts for two focus regions in or near the tropical belt, the river basins of the Karun in Iran and the Sao Francisco in Brazil. Both are characterized by strong seasonality and semi-aridity, so that predictability across various time-scales is in high demand. Among other things, it is found that from the start of the water year (autumn), areal precipitation is predictable with good skill for the Karun basin two and a half months ahead; for the Sao Francisco it is only one month, longer-term prediction skill is just above the critical level.},
  language  = {en}
}
@article{Schmidt2021,
  author    = {Schmidt, Imanuel Clemens},
  title     = {A Secular Tradition},
  series = {PaRDeS : Journal of the Association for Jewish Studies in Germany},
  journal   = {PaRDeS : Journal of the Association for Jewish Studies in Germany},
  number    = {27},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-520-0},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-53286},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-532868},
  pages     = {85 -- 100},
  year      = {2021},
  abstract  = {This article focuses on the social philosopher Horace Kallen and the revisions he made to the concept of cultural pluralism that he first developed in the early 20th century, applying it to postwar America and the young State of Israel. It shows how he opposed the assumption that the United States' social order was based on a "Judeo-Christian tradition." By constructing pluralism as a civil religion and carving out space for secular self-understandings in midcentury America, Kallen attempted to preserve the integrity of his earlier political visions, developed during World War I, of pluralist societies in the United States and Palestine within an internationalist global order. While his perspective on the State of Israel was largely shaped by his American experiences, he revised his approach to politically functionalizing religious traditions as he tested his American understanding of a secular, pluralist society against the political theology effective in the State of Israel. The trajectory of Kallen's thought points to fundamental questions about the compatibility of American and Israeli understandings of religion's function in society and its relation to political belonging, especially in light of their transnational connection through American Jewish support for the recently established state.},
  language  = {en}
}
@article{GailletonMuddClubbetal.2019,
  author    = {Gailleton, Boris and Mudd, Simon M. and Clubb, Fiona J. and Peifer, Daniel and Hurst, Martin D.},
  title     = {A segmentation approach for the reproducible extraction and quantification of knickpoints from river long profiles},
  series = {Earth surface dynamics},
  volume    = {7},
  journal   = {Earth surface dynamics},
  number    = {1},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {2196-6311},
  doi       = {10.5194/esurf-7-211-2019},
  pages     = {211 -- 230},
  year      = {2019},
  abstract  = {Changes in the steepness of river profiles or abrupt vertical steps (i.e. waterfalls) are thought to be indicative of changes in erosion rates, lithology or other factors that affect landscape evolution. These changes are referred to as knickpoints or knickzones and are pervasive in bedrock river systems. Such features are thought to reveal information about landscape evolution and patterns of erosion, and therefore their locations are often reported in the geomorphic literature. It is imperative that studies reporting knickpoints and knickzones use a reproducible method of quantifying their locations, as their number and spatial distribution play an important role in interpreting tectonically active landscapes. In this contribution we introduce a reproducible knickpoint and knickzone extraction algorithm that uses river profiles transformed by integrating drainage area along channel length (the so-called integral or chi method). The profile is then statistically segmented and the differing slopes and step changes in the elevations of these segments are used to identify knickpoints, knickzones and their relative magnitudes. The output locations of identified knickpoints and knickzones compare favourably with human mapping: we test the method on Santa Cruz Island, CA, using previously reported knickzones and also test the method against a new dataset from the Quadrilatero Ferrifero in Brazil. The algorithm allows for the extraction of varying knickpoint morphologies, including stepped, positive slope-break (concave upward) and negative slope-break knickpoints. We identify parameters that most affect the resulting knickpoint and knickzone locations and provide guidance for both usage and outputs of the method to produce reproducible knickpoint datasets.},
  language  = {en}
}
@article{MummHermanussen2021,
  author    = {Mumm, Rebekka and Hermanussen, Michael},
  title     = {A short note on the BMI and on secular changes in BMI},
  series = {Human biology and public health},
  journal   = {Human biology and public health},
  number    = {2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2748-9957},
  doi       = {10.52905/hbph.v2.17},
  year      = {2021},
  abstract  = {Human size changes over time with worldwide secular trends in height, weight, and body mass index (BMI). There is general agreement to relate the state of nutrition to height and weight, and to ratios of weight-to-height. The BMI is a ratio. It is commonly used to classify underweight, overweight and obesity in adults. Yet, the BMI is inappropriate to provide any immediate information on body composition. It is accepted that the BMI is "a simple index to classify underweight, overweight and obesity in adults". It is stated that "policies, programmes and investments need to be "nutrition-sensitive", which means they must have positive impacts on nutrition". It is also stated that "a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions". But these statements are neither warranted by arithmetic considerations, nor by historic evidence. Measuring the BMI is an appropriate screening tool for detecting an unusual weight-to-height ratio, but the BMI is an inappropriate tool for estimating body composition, or suggesting medical and health policy decisions.},
  language  = {en}
}
@article{SchlemmLevermann2021,
  author    = {Schlemm, Tanja and Levermann, Anders},
  title     = {A simple parametrization of m{\´e}lange buttressing for calving glaciers},
  series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union},
  volume    = {15},
  journal   = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union},
  number    = {2},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1994-0416},
  doi       = {10.5194/tc-15-531-2021},
  pages     = {531 -- 545},
  year      = {2021},
  abstract  = {Both ice sheets in Greenland and Antarctica are discharging ice into the ocean. In many regions along the coast of the ice sheets, the icebergs calve into a bay. If the addition of icebergs through calving is faster than their transport out of the embayment, the icebergs will be frozen into a melange with surrounding sea ice in winter. In this case, the buttressing effect of the ice melange can be considerably stronger than any buttressing by mere sea ice would be. This in turn stabilizes the glacier terminus and leads to a reduction in calving rates. Here we propose a simple parametrization of ice melange buttressing which leads to an upper bound on calving rates and can be used in numerical and analytical modelling.},
  language  = {en}
}
@article{SchlemmLevermann2019,
  author    = {Schlemm, Tanja and Levermann, Anders},
  title     = {A simple stress-based cliff-calving law},
  series = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union},
  volume    = {13},
  journal   = {The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union},
  number    = {9},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1994-0416},
  doi       = {10.5194/tc-13-2475-2019},
  pages     = {2475 -- 2488},
  year      = {2019},
  abstract  = {Over large coastal regions in Greenland and Antarctica the ice sheet calves directly into the ocean. In contrast to ice-shelf calving, an increase in calving from grounded glaciers contributes directly to sea-level rise. Ice cliffs with a glacier freeboard larger than approximate to 100 m are currently not observed, but it has been shown that such ice cliffs are increasingly unstable with increasing ice thickness. This cliff calving can constitute a self-amplifying ice loss mechanism that may significantly alter sea-level projections both of Greenland and Antarctica. Here we seek to derive a minimalist stress-based parametrization for cliff calving from grounded glaciers whose freeboards exceed the 100m stability limit derived in previous studies. This will be an extension of existing calving laws for tidewater glaciers to higher ice cliffs. To this end we compute the stress field for a glacier with a simplified two-dimensional geometry from the two-dimensional Stokes equation. First we assume a constant yield stress to derive the failure region at the glacier front from the stress field within the glacier. Secondly, we assume a constant response time of ice failure due to exceedance of the yield stress. With this strongly constraining but very simple set of assumptions we propose a cliff-calving law where the calving rate follows a power-law dependence on the freeboard of the ice with exponents between 2 and 3, depending on the relative water depth at the calving front. The critical freeboard below which the ice front is stable decreases with increasing relative water depth of the calving front. For a dry water front it is, for example, 75 m. The purpose of this study is not to provide a comprehensive calving law but to derive a particularly simple equation with a transparent and minimalist set of assumptions.},
  language  = {en}
}
@article{BalderjahnAppenfeller2023,
  author    = {Balderjahn, Ingo and Appenfeller, Dennis},
  title     = {A social marketing approach to voluntary simplicity},
  series = {Sustainability},
  volume    = {15},
  journal   = {Sustainability},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2071-1050},
  doi       = {10.3390/su15032302},
  pages     = {17},
  year      = {2023},
  abstract  = {Higher eco-efficiency will not be enough to slow global warming caused by climate change. To keep global warming to 2 degrees, people also need to reduce their consumption. At present, however, many who would be able to do so seem unwilling to comply. Given the threats of a runaway climate change, urgent measures are needed to promote less personal consumption. This study, therefore, examines whether social marketing consume-less appeals can be used to encourage consumers to voluntarily abstain from consumption. As part of an online experiment with nearly 2000 randomly sampled users of an online platform for sustainable consumption, we tested the effectiveness of five different "consume-less" appeals based on traditional advertising formats (including emotional, informational, and social claims). The study shows that consume-less appeals are capable of limiting personal desire to buy. However, significant differences in the effectiveness of the appeal formats used in this study were observed. In addition, we found evidence of rebound effects, which leads us to critically evaluate the overall potential of social marketing to promote more resource-conserving lifestyles. While commercial consumer-free appeals have previously been studied (e.g., Patagonia's "Don't Buy This Jacked"), this study on the effectiveness of non-commercial consume-free appeals is novel and provides new insights.},
  language  = {en}
}
@article{KoertingKoellnerKurasetal.2021,
  author    = {K{\"o}rting, Friederike Magdalena and K{\"o}llner, Nicole and Kuras, Agnieszka and B{\"o}sche, Nina Kristin and Rogass, Christian and Mielke, Christian and Elger, Kirsten and Altenberger, Uwe},
  title     = {A solar optical hyperspectral library of rare-earth-bearing minerals, rare-earth oxide powders, copper-bearing minerals and Apliki mine surface samples},
  series = {Earth system science data : ESSD},
  volume    = {13},
  journal   = {Earth system science data : ESSD},
  publisher = {Copernics Publications},
  address   = {Katlenburg-Lindau},
  issn      = {1866-3508},
  doi       = {10.5194/essd-13-923-2021},
  pages     = {923 -- 942},
  year      = {2021},
  abstract  = {Mineral resource exploration and mining is an essential part of today's high-tech industry. Elements such as rare-earth elements (REEs) and copper are, therefore, in high demand. Modern exploration techniques from multiple platforms (e.g., spaceborne and airborne), to detect and map the spectral characteristics of the materials of interest, require spectral libraries as an essential reference. They include field and laboratory spectral information in combination with geochemical analyses for validation. Here, we present a collection of REE- and copper-related hyperspectral spectra with associated geochemical information. The libraries contain reflectance spectra from rare-earth element oxides, REE-bearing minerals, copper-bearing minerals and mine surface samples from the Apliki copper-gold-pyrite mine in the Republic of Cyprus. The samples were measured with the HySpex imaging spectrometers in the visible and near infrared (VNIR) and shortwave infrared (SWIR) range (400-2500 nm). The geochemical validation of each sample is provided with the reflectance spectra. The spectral libraries are openly available to assist future mineral mapping campaigns and laboratory spectroscopic analyses. The spectral libraries and corresponding geochemistry are published via GFZ Data Services with the following DOIs: https://doi.org/10.5880/GFZ.1.4.2019.004 (13 REE-bearing minerals and 16 oxide powders, Koerting et al., 2019a), https://doi.org/10.5880/GFZ.1.4.2019.003 (20 copper-bearing minerals, Koellner et al., 2019), and https://doi.org/10.5880/GFZ.1.4.2019.005 (37 copper-bearing surface material samples from the Apliki coppergold-pyrite mine in Cyprus, Koerting et al., 2019b). All spectral libraries are united and comparable by the internally consistent method of hyperspectral data acquisition in the laboratory.},
  language  = {en}
}
@article{PickEffenbergerZhelavskayaetal.2019,
  author    = {Pick, Leonie and Effenberger, Frederic and Zhelavskaya, Irina and Korte, Monika},
  title     = {A Statistical Classifier for Historical Geomagnetic Storm Drivers Derived Solely From Ground-Based Magnetic Field Measurements},
  series = {Earth and Space Science},
  volume    = {6},
  journal   = {Earth and Space Science},
  publisher = {American Geophysical Union},
  address   = {Malden, Mass.},
  issn      = {2333-5084},
  doi       = {10.1029/2019EA000726},
  pages     = {2000 -- 2015},
  year      = {2019},
  abstract  = {Solar wind observations show that geomagnetic storms are mainly driven by interplanetary coronal mass ejections (ICMEs) and corotating or stream interaction regions (C/SIRs). We present a binary classifier that assigns one of these drivers to 7,546 storms between 1930 and 2015 using ground-based geomagnetic field observations only. The input data consists of the long-term stable Hourly Magnetospheric Currents index alongside the corresponding midlatitude geomagnetic observatory time series. This data set provides comprehensive information on the global storm time magnetic disturbance field, particularly its spatial variability, over eight solar cycles. For the first time, we use this information statistically with regard to an automated storm driver identification. Our supervised classification model significantly outperforms unskilled baseline models (78\% accuracy with 26[19]\% misidentified interplanetary coronal mass ejections [corotating or stream interaction regions]) and delivers plausible driver occurrences with regard to storm intensity and solar cycle phase. Our results can readily be used to advance related studies fundamental to space weather research, for example, studies connecting galactic cosmic ray modulation and geomagnetic disturbances. They are fully reproducible by means of the underlying open-source software (Pick, 2019, http://doi.org/10.5880/GFZ.2.3.2019.003)},
  language  = {en}
}
@article{KuekenWenderingLangaryetal.2021,
  author    = {K{\"u}ken, Anika and Wendering, Philipp and Langary, Damoun and Nikoloski, Zoran},
  title     = {A structural property for reduction of biochemical networks},
  series = {Scientific reports},
  volume    = {11},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-96835-1},
  pages     = {11},
  year      = {2021},
  abstract  = {Large-scale biochemical models are of increasing sizes due to the consideration of interacting organisms and tissues. Model reduction approaches that preserve the flux phenotypes can simplify the analysis and predictions of steady-state metabolic phenotypes. However, existing approaches either restrict functionality of reduced models or do not lead to significant decreases in the number of modelled metabolites. Here, we introduce an approach for model reduction based on the structural property of balancing of complexes that preserves the steady-state fluxes supported by the network and can be efficiently determined at genome scale. Using two large-scale mass-action kinetic models of Escherichia coli, we show that our approach results in a substantial reduction of 99\% of metabolites. Applications to genome-scale metabolic models across kingdoms of life result in up to 55\% and 85\% reduction in the number of metabolites when arbitrary and mass-action kinetics is assumed, respectively. We also show that predictions of the specific growth rate from the reduced models match those based on the original models. Since steady-state flux phenotypes from the original model are preserved in the reduced, the approach paves the way for analysing other metabolic phenotypes in large-scale biochemical networks.},
  language  = {en}
}
@article{RodriguezZuluagaStolleYamazakietal.2021,
  author    = {Rodr{\´i}guez Zuluaga, Juan and Stolle, Claudia and Yamazaki, Yosuke and Xiong, Chao and England, Scott L.},
  title     = {A synoptic-scale wavelike structure in the nighttime equatorial ionization anomaly},
  series = {Earth and Space Science : ESS},
  volume    = {8},
  journal   = {Earth and Space Science : ESS},
  number    = {2},
  publisher = {American Geophysical Union},
  address   = {Malden, Mass.},
  issn      = {2333-5084},
  doi       = {10.1029/2020EA001529},
  pages     = {10},
  year      = {2021},
  abstract  = {Both ground- and satellite-based airglow imaging have significantly contributed to understanding the low-latitude ionosphere, especially the morphology and dynamics of the equatorial ionization anomaly (EIA). The NASA Global-scale Observations of the Limb and Disk (GOLD) mission focuses on far-ultraviolet airglow images from a geostationary orbit at 47.5 degrees W. This region is of particular interest at low magnetic latitudes because of the high magnetic declination (i.e., about -20 degrees) and proximity of the South Atlantic magnetic anomaly. In this study, we characterize an exciting feature of the nighttime EIA using GOLD observations from October 5, 2018 to June 30, 2020. It consists of a wavelike structure of a few thousand kilometers seen as poleward and equatorward displacements of the EIA-crests. Initial analyses show that the synoptic-scale structure is symmetric about the dip equator and appears nearly stationary with time over the night. In quasi-dipole coordinates, maxima poleward displacements of the EIA-crests are seen at about +/- 12 degrees latitude and around 20 and 60 degrees longitude (i.e., in geographic longitude at the dip equator, about 53 degrees W and 14 degrees W). The wavelike structure presents typical zonal wavelengths of about 6.7 x 10(3) km and 3.3 x 10(3) km. The structure's occurrence and wavelength are highly variable on a day-to-day basis with no apparent dependence on geomagnetic activity. In addition, a cluster or quasi-periodic wave train of equatorial plasma depletions (EPDs) is often detected within the synoptic-scale structure. We further outline the difference in observing these EPDs from FUV images and in situ measurements during a GOLD and Swarm mission conjunction.},
  language  = {en}
}
@article{PrillWalterKrolikowskaetal.2021,
  author    = {Prill, Robert and Walter, Marina and Kr{\´o}likowska, Aleksandra and Becker, Roland},
  title     = {A systematic review of diagnostic accuracy and clinical applications of wearable movement sensors for knee joint rehabilitation},
  series = {Sensors},
  volume    = {21},
  journal   = {Sensors},
  number    = {24},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s21248221},
  pages     = {14},
  year      = {2021},
  abstract  = {In clinical practice, only a few reliable measurement instruments are available for monitoring knee joint rehabilitation. Advances to replace motion capturing with sensor data measurement have been made in the last years. Thus, a systematic review of the literature was performed, focusing on the implementation, diagnostic accuracy, and facilitators and barriers of integrating wearable sensor technology in clinical practices based on a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. For critical appraisal, the COSMIN Risk of Bias tool for reliability and measurement of error was used. PUBMED, Prospero, Cochrane database, and EMBASE were searched for eligible studies. Six studies reporting reliability aspects in using wearable sensor technology at any point after knee surgery in humans were included. All studies reported excellent results with high reliability coefficients, high limits of agreement, or a few detectable errors. They used different or partly inappropriate methods for estimating reliability or missed reporting essential information. Therefore, a moderate risk of bias must be considered. Further quality criterion studies in clinical settings are needed to synthesize the evidence for providing transparent recommendations for the clinical use of wearable movement sensors in knee joint rehabilitation.},
  language  = {en}
}
@article{PradhanCostaRybskietal.2017,
  author    = {Pradhan, Prajal and Costa, Lu{\´i}s F{\´i}l{\´i}pe Carvalho da and Rybski, Diego and Lucht, Wolfgang and Kropp, J{\"u}rgen},
  title     = {A Systematic Study of Sustainable Development Goal (SDG) Interactions},
  series = {Earths Future},
  volume    = {5},
  journal   = {Earths Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000632},
  pages     = {1169 -- 1179},
  year      = {2017},
  abstract  = {Sustainable development goals (SDGs) have set the 2030 agenda to transform our world by tackling multiple challenges humankind is facing to ensure well-being, economic prosperity, and environmental protection. In contrast to conventional development agendas focusing on a restricted set of dimensions, the SDGs provide a holistic and multidimensional view on development. Hence, interactions among the SDGs may cause diverging results. To analyze the SDG interactions we systematize the identification of synergies and trade-offs using official SDG indicator data for 227 countries. A significant positive correlation between a pair of SDG indicators is classified as a synergy while a significant negative correlation is classified as a trade-off. We rank synergies and trade-offs between SDGs pairs on global and country scales in order to identify the most frequent SDG interactions. For a given SDG, positive correlations between indicator pairs were found to outweigh the negative ones in most countries. Among SDGs the positive and negative correlations between indicator pairs allowed for the identification of particular global patterns. SDG 1 (No poverty) has synergetic relationship with most of the other goals, whereas SDG 12 (Responsible consumption and production) is the goal most commonly associated with trade-offs. The attainment of the SDG agenda will greatly depend on whether the identified synergies among the goals can be leveraged. In addition, the highlighted trade-offs, which constitute obstacles in achieving the SDGs, need to be negotiated and made structurally nonobstructive by deeper changes in the current strategies.},
  language  = {en}
}
@article{KabothBahrBahrZeedenetal.2021,
  author    = {Kaboth-Bahr, Stefanie and Bahr, Andr{\´e} and Zeeden, Christian and Yamoah, Kweku A. and Lone, Mahjoor Ahmad and Chuang, Chih-Kai and L{\"o}wemark, Ludvig and Wei, Kuo-Yen},
  title     = {A tale of shifting relations},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-85444-7},
  pages     = {10},
  year      = {2021},
  abstract  = {Understanding the dynamics between the East Asian summer (EASM) and winter monsoon (EAWM) is needed to predict their variability under future global warming scenarios. Here, we investigate the relationship between EASM and EAWM as well as the mechanisms driving their variability during the last 10,000 years by stacking marine and terrestrial (non-speleothem) proxy records from the East Asian realm. This provides a regional and proxy independent signal for both monsoonal systems. The respective signal was subsequently analysed using a linear regression model. We find that the phase relationship between EASM and EAWM is not time-constant and significantly depends on orbital configuration changes. In addition, changes in the Atlantic Meridional Overturning circulation, Arctic sea-ice coverage, El Ni{\~n}o-Southern Oscillation and Sun Spot numbers contributed to millennial scale changes in the EASM and EAWM during the Holocene. We also argue that the bulk signal of monsoonal activity captured by the stacked non-speleothem proxy records supports the previously argued bias of speleothem climatic archives to moisture source changes and/or seasonality.},
  language  = {en}
}
@article{CaoTianAndreevetal.2020,
  author    = {Cao, Xianyong and Tian, Fang and Andreev, Andrei and Anderson, Patricia M. and Lozhkin, Anatoly V. and Bezrukova, Elena and Ni, Jian and Rudaya, Natalia and Stobbe, Astrid and Wieczorek, Mareike and Herzschuh, Ulrike},
  title     = {A taxonomically harmonized and temporally standardized fossil pollen dataset from Siberia covering the last 40 kyr},
  series = {Earth System Science Data},
  volume    = {12},
  journal   = {Earth System Science Data},
  number    = {1},
  publisher = {Copernics Publications},
  address   = {Katlenburg-Lindau},
  issn      = {1866-3508},
  doi       = {10.5194/essd-12-119-2020},
  pages     = {119 -- 135},
  year      = {2020},
  abstract  = {Pollen records from Siberia are mostly absent in global or Northern Hemisphere synthesis works. Here we present a taxonomically harmonized and temporally standardized pollen dataset that was synthesized using 173 palynological records from Siberia and adjacent areas (northeastern Asia, 42-75 degrees N, 50-180 degrees E). Pollen data were taxonomically harmonized, i.e. the original 437 taxa were assigned to 106 combined pollen taxa. Age-depth models for all records were revised by applying a constant Bayesian age-depth modelling routine. The pollen dataset is available as count data and percentage data in a table format (taxa vs. samples), with age information for each sample. The dataset has relatively few sites covering the last glacial period between 40 and 11.5 ka (calibrated thousands of years before 1950 CE) particularly from the central and western part of the study area. In the Holocene period, the dataset has many sites from most of the area, with the exception of the central part of Siberia. Of the 173 pollen records, 81 \% of pollen counts were downloaded from open databases (GPD, EPD, PANGAEA) and 10 \% were contributions by the original data gatherers, while a few were digitized from publications. Most of the pollen records originate from peatlands (48 \%) and lake sediments (33 \%). Most of the records (83 \%) have >= 3 dates, allowing the establishment of reliable chronologies. The dataset can be used for various purposes, including pollen data mapping (example maps for Larix at selected time slices are shown) as well as quantitative climate and vegetation reconstructions. The datasets for pollen counts and pollen percentages are available at https://doi.org/10.1594/PANGAEA.898616 (Cao et al., 2019a), also including the site information, data source, original publication, dating data, and the plant functional type for each pollen taxa.},
  language  = {en}
}
@article{ScheibelTrappLimbergeretal.2020,
  author    = {Scheibel, Willy and Trapp, Matthias and Limberger, Daniel and D{\"o}llner, J{\"u}rgen Roland Friedrich},
  title     = {A taxonomy of treemap visualization techniques},
  series = {Science and Technology Publications},
  journal   = {Science and Technology Publications},
  publisher = {Springer},
  address   = {Berlin},
  pages     = {8},
  year      = {2020},
  abstract  = {A treemap is a visualization that has been specifically designed to facilitate the exploration of tree-structured data and, more general, hierarchically structured data. The family of visualization techniques that use a visual metaphor for parent-child relationships based "on the property of containment" (Johnson, 1993) is commonly referred to as treemaps. However, as the number of variations of treemaps grows, it becomes increasingly important to distinguish clearly between techniques and their specific characteristics. This paper proposes to discern between Space-filling Treemap TS, Containment Treemap TC, Implicit Edge Representation Tree TIE, and Mapped Tree TMT for classification of hierarchy visualization techniques and highlights their respective properties. This taxonomy is created as a hyponymy, i.e., its classes have an is-a relationship to one another: TS TC TIE TMT. With this proposal, we intend to stimulate a discussion on a more unambiguous classification of treemaps and, furthermore, broaden what is understood by the concept of treemap itself.},
  language  = {en}
}
@article{NohrHaugsbakken2023,
  author    = {Nohr, Magnus and Haugsbakken, Halvdan},
  title     = {A taxonomy of video genres as a scaffolding strategy for video making in education},
  series = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?},
  journal   = {EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?},
  editor    = {Meinel, Christoph and Schweiger, Stefanie and Staubitz, Thomas and Conrad, Robert and Alario Hoyos, Carlos and Ebner, Martin and Sancassani, Susanna and Żur, Agnieszka and Friedl, Christian and Halawa, Sherif and Gamage, Dilrukshi and Scott, Jeffrey and Kristine Jonson Carlon, May and Deville, Yves and Gaebel, Michael and Delgado Kloos, Carlos and von Schmieden, Karen},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  doi       = {10.25932/publishup-62429},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624294},
  pages     = {201 -- 220},
  year      = {2023},
  abstract  = {This research paper aims to introduce a novel practitioner-oriented and research-based taxonomy of video genres. This taxonomy can serve as a scaffolding strategy to support educators throughout the entire educational system in creating videos for pedagogical purposes. A taxonomy of video genres is essential as videos are highly valued resources among learners. Although the use of videos in education has been extensively researched and well-documented in systematic research reviews, gaps remain in the literature. Predominantly, researchers employ sophisticated quantitative methods and similar approaches to measure the performance of videos. This trend has led to the emergence of a strong learning analytics research tradition with its embedded literature. This body of research includes analysis of performance of videos in online courses such as Massive Open Online Courses (MOOCs). Surprisingly, this same literature is limited in terms of research outlining approaches to designing and creating educational videos, which applies to both video-based learning and online courses. This issue results in a knowledge gap, highlighting the need for developing pedagogical tools and strategies for video making. These can be found in frameworks, guidelines, and taxonomies, which can serve as scaffolding strategies. In contrast, there appears to be very few frameworks available for designing and creating videos for pedagogica purposes, apart from a few well-known frameworks. In this regard, this research paper proposes a novel taxonomy of video genres that educators can utilize when creating videos intended for use in either video-based learning environments or online courses. To create this taxonomy, a large number of videos from online courses were collected and analyzed using a mixed-method research design approach.},
  language  = {en}
}
@misc{FrankKreitz2018,
  author    = {Frank, Mario and Kreitz, Christoph},
  title     = {A theorem prover for scientific and educational purposes},
  series = {Electronic proceedings in theoretical computer science},
  journal   = {Electronic proceedings in theoretical computer science},
  number    = {267},
  publisher = {Open Publishing Association},
  address   = {Sydney},
  issn      = {2075-2180},
  doi       = {10.4204/EPTCS.267.4},
  pages     = {59 -- 69},
  year      = {2018},
  abstract  = {We present a prototype of an integrated reasoning environment for educational purposes. The presented tool is a fragment of a proof assistant and automated theorem prover. We describe the existing and planned functionality of the theorem prover and especially the functionality of the educational fragment. This currently supports working with terms of the untyped lambda calculus and addresses both undergraduate students and researchers. We show how the tool can be used to support the students' understanding of functional programming and discuss general problems related to the process of building theorem proving software that aims at supporting both research and education.},
  language  = {en}
}
@article{CordonnierBovyBraun2019,
  author    = {Cordonnier, Guillaume and Bovy, Benoit and Braun, Jean},
  title     = {A versatile, linear complexity algorithm for flow routing in topographies with depressions},
  series = {Earth surface dynamics},
  volume    = {7},
  journal   = {Earth surface dynamics},
  number    = {2},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {2196-6311},
  doi       = {10.5194/esurf-7-549-2019},
  pages     = {549 -- 562},
  year      = {2019},
  abstract  = {We present a new algorithm for solving the common problem of flow trapped in closed depressions within digital elevation models, as encountered in many applications relying on flow routing. Unlike other approaches (e.g., the Priority-Flood depression filling algorithm), this solution is based on the explicit computation of the flow paths both within and across the depressions through the construction of a graph connecting together all adjacent drainage basins. Although this represents many operations, a linear time complexity can be reached for the whole computation, making it very efficient. Compared to the most optimized solutions proposed so far, we show that this algorithm of flow path enforcement yields the best performance when used in landscape evolution models. In addition to its efficiency, our proposed method also has the advantage of letting the user choose among different strategies of flow path enforcement within the depressions (i.e., filling vs. carving). Furthermore, the computed graph of basins is a generic structure that has the potential to be reused for solving other problems as well, such as the simulation of erosion. This sequential algorithm may be helpful for those who need to, e.g., process digital elevation models of moderate size on single computers or run batches of simulations as part of an inference study.},
  language  = {en}
}
@article{SurethKalkuhlEdenhoferetal.2023,
  author    = {Sureth, Michael and Kalkuhl, Matthias and Edenhofer, Ottmar and Rockstr{\"o}m, Johan},
  title     = {A welfare economic approach to planetary boundaries},
  series = {Jahrb{\"u}cher f{\"u}r National{\"o}konomie und Statistik},
  volume    = {243},
  journal   = {Jahrb{\"u}cher f{\"u}r National{\"o}konomie und Statistik},
  number    = {5},
  publisher = {De Gruyter Oldenbourg},
  address   = {Berlin},
  issn      = {0021-4027},
  doi       = {10.1515/jbnst-2022-0022},
  pages     = {477 -- 542},
  year      = {2023},
  abstract  = {The crises of both the climate and the biosphere are manifestations of the imbalance between human extractive, and polluting activities and the Earth's regenerative capacity. Planetary boundaries define limits for biophysical systems and processes that regulate the stability and life support capacity of the Earth system, and thereby also define a safe operating space for humanity on Earth. Budgets associated to planetary boundaries can be understood as global commons: common pool resources that can be utilized within finite limits. Despite the analytical interpretation of planetary boundaries as global commons, the planetary boundaries framework is missing a thorough integration into economic theory. We aim to bridge the gap between welfare economic theory and planetary boundaries as derived in the natural sciences by presenting a unified theory of cost-benefit and cost-effectiveness analysis. Our pragmatic approach aims to overcome shortcomings of the practical applications of CEA and CBA to environmental problems of a planetary scale. To do so, we develop a model framework and explore decision paradigms that give guidance to setting limits on human activities. This conceptual framework is then applied to planetary boundaries. We conclude by using the realized insights to derive a research agenda that builds on the understanding of planetary boundaries as global commons.},
  language  = {en}
}
@article{BoekstegersMarcelainBarahonaPonceetal.2020,
  author    = {Boekstegers, Felix and Marcelain, Katherine and Barahona Ponce, Carol and Baez Benavides, Pablo F. and M{\"u}ller, Bettina and de Toro, Gonzalo and Retamales, Javier and Barajas, Olga and Ahumada, Monica and Aleksandrova, Krasimira and Bermejo, Justo Lorenzo},
  title     = {ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans},
  series = {Cancer Epidemiology},
  volume    = {65},
  journal   = {Cancer Epidemiology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  pages     = {5},
  year      = {2020},
  abstract  = {Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.},
  language  = {en}
}
@article{Stellmacher2023,
  author    = {Stellmacher, Martha},
  title     = {Abgelegte Musik},
  series = {Genisa-Bl{\"a}tter IV},
  journal   = {Genisa-Bl{\"a}tter IV},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-539-2},
  doi       = {10.25932/publishup-58490},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-584908},
  pages     = {83 -- 95},
  year      = {2023},
  language  = {de}
}
@article{CortiCioniFranceschinietal.2019,
  author    = {Corti, Giacomo and Cioni, Raffaello and Franceschini, Zara and Sani, Federico and Scaillet, Stephane and Molin, Paola and Isola, Ilaria and Mazzarini, Francesco and Brune, Sascha and Keir, Derek and Erbello Doelesso, Asfaw and Muluneh, Ameha and Illsley-Kemp, Finnigan and Glerum, Anne},
  title     = {Aborted propagation of the Ethiopian rift caused by linkage with the Kenyan rift},
  series = {Nature Communications},
  volume    = {10},
  journal   = {Nature Communications},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-019-09335-2},
  pages     = {11},
  year      = {2019},
  abstract  = {Continental rift systems form by propagation of isolated rift segments that interact, and eventually evolve into continuous zones of deformation. This process impacts many aspects of rifting including rift morphology at breakup, and eventual ocean-ridge segmentation. Yet, rift segment growth and interaction remain enigmatic. Here we present geological data from the poorly documented Ririba rift (South Ethiopia) that reveals how two major sectors of the East African rift, the Kenyan and Ethiopian rifts, interact. We show that the Ririba rift formed from the southward propagation of the Ethiopian rift during the Pliocene but this propagation was short-lived and aborted close to the Pliocene-Pleistocene boundary. Seismicity data support the abandonment of laterally offset, overlapping tips of the Ethiopian and Kenyan rifts. Integration with new numerical models indicates that rift abandonment resulted from progressive focusing of the tectonic and magmatic activity into an oblique, throughgoing rift zone of near pure extension directly connecting the rift sectors.},
  language  = {en}
}
@article{DoeringGrigorievTapioetal.2021,
  author    = {Doering, Ulrike and Grigoriev, Dmitry and Tapio, Kosti and Rosencrantz, Sophia and Rosencrantz, Ruben R. and Bald, Ilko and B{\"o}ker, Alexander},
  title     = {About the mechanism of ultrasonically induced protein capsule formation},
  series = {RSC Advances : an international journal to further the chemical sciences / Royal Society of Chemistry},
  volume    = {11},
  journal   = {RSC Advances : an international journal to further the chemical sciences / Royal Society of Chemistry},
  number    = {27},
  publisher = {RSC Publishing},
  address   = {London},
  issn      = {2046-2069},
  doi       = {10.1039/d0ra08100k},
  pages     = {16152 -- 16157},
  year      = {2021},
  abstract  = {In this paper, we propose a consistent mechanism of protein microcapsule formation upon ultrasound treatment. Aqueous suspensions of bovine serum albumin (BSA) microcapsules filled with toluene are prepared by use of high-intensity ultrasound following a reported method. Stabilization of the oil-in-water emulsion by the adsorption of the protein molecules at the interface of the emulsion droplets is accompanied by the creation of the cross-linked capsule shell due to formation of intermolecular disulfide bonds caused by highly reactive species like superoxide radicals generated sonochemically. The evidence for this mechanism, which until now remained elusive and was not proven properly, is presented based on experimental data from SDS-PAGE, Raman spectroscopy and dynamic light scattering.},
  language  = {en}
}
@article{GoswamiBoersRheinwaltetal.2018,
  author    = {Goswami, Bedartha and Boers, Niklas and Rheinwalt, Aljoscha and Marwan, Norbert and Heitzig, Jobst and Breitenbach, Sebastian Franz Martin and Kurths, J{\"u}rgen},
  title     = {Abrupt transitions in time series with uncertainties},
  series = {Nature Communications},
  volume    = {9},
  journal   = {Nature Communications},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-017-02456-6},
  pages     = {10},
  year      = {2018},
  abstract  = {Identifying abrupt transitions is a key question in various disciplines. Existing transition detection methods, however, do not rigorously account for time series uncertainties, often neglecting them altogether or assuming them to be independent and qualitatively similar. Here, we introduce a novel approach suited to handle uncertainties by representing the time series as a time-ordered sequence of probability density functions. We show how to detect abrupt transitions in such a sequence using the community structure of networks representing probabilities of recurrence. Using our approach, we detect transitions in global stock indices related to well-known periods of politico-economic volatility. We further uncover transitions in the El Ni{\~n}o-Southern Oscillation which coincide with periods of phase locking with the Pacific Decadal Oscillation. Finally, we provide for the first time an 'uncertainty-aware' framework which validates the hypothesis that ice-rafting events in the North Atlantic during the Holocene were synchronous with a weakened Asian summer monsoon.},
  language  = {en}
}
@techreport{MeyerRichterRichter2022,
  author    = {Meyer, Andr{\´e} and Richter, Eric and Richter, Dirk},
  title     = {Abschlussbericht zur wissenschaftlichen Evaluation der Werkstatt "Schule leiten"},
  doi       = {10.25932/publishup-54886},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-548869},
  pages     = {75},
  year      = {2022},
  abstract  = {Der vorliegende Abschlussbericht umfasst die Ergebnisse der wissenschaftlichen Evaluation der Werkstatt „Schule leiten". Bei dieser Werkstatt handelt es sich um ein 18-monatiges Fortbildungsangebot f{\"u}r Schulleitungen, das durch die Deutsche Schulakademie konzipiert und in Kooperation mit dem saarl{\"a}ndischen Kultusministerium f{\"u}r Bildung und Kultur sowie dem saarl{\"a}ndischen Landesinstitut f{\"u}r P{\"a}dagogik und Medien durchgef{\"u}hrt wurde. Im Zeitraum 2016-2020 absolvierten jeweils zwei Personen des Schulleitungsteams allgemeinbildender Schulen erstmalig in insgesamt drei Durchg{\"a}ngen verschiedene Angebote der Werkstatt. Weiterhin erhielten die Teilnehmenden die Aufgaben, im Zuge ihres Fortbildungsbesuches ein individuelles Schulentwicklungsprojekt zu planen, zu entwickeln und unter Anleitung der Werkstatt in der Schule zu implementieren. Zur {\"U}berpr{\"u}fung der wahrgenommenen Qualit{\"a}t sowie der Wirksamkeit des Fortbildungsangebotes wurde die Universit{\"a}t Potsdam, Arbeitsbereich Prof. Dr. Dirk Richter, beauftragt. Der vorliegende Bericht pr{\"a}sentiert die Evaluationsergebnisse der Durchg{\"a}nge 2 und 3. Im Zentrum der Evaluation stehen die folgenden Forschungsfragen: (1) Wie beurteilen die Teilnehmenden die Qualit{\"a}t der Werkstatt „Schule leiten"? (2) Inwiefern hat die Werkstatt „Schule leiten" dazu beigetragen, die Leitungskompetenzen (u.a. Einstellungen und F{\"u}hrungshandeln) der Teilnehmenden zu st{\"a}rken? sowie (3) Wie haben sich schulische Strukturen und Prozesse zur F{\"o}rderung von Schulentwicklung in den teilnehmenden Schulen durch die Werkstatt „Schule leiten" ver{\"a}ndert? Zur Beantwortung der Fragestellungen wurden eine Reihe schriftlicher Befragungen mit den teilnehmenden Schulleitungen sowie den Lehrkr{\"a}ften der teilnehmenden Schulen durchgef{\"u}hrt. Diese Befragungen erfolgten sowohl begleitend zum Fortbildungsprogramm (nach Absolvieren der einzelnen Angebote) sowie in einem Pr{\"a}-Post-Follow-Up-Design. Weiterhin wurden im Rahmen einer qualitativen Begleitstudie verschiedene Personen (Schulleitung, Mitglieder des Schulleitungsteams, Lehrkr{\"a}fte) von insgesamt f{\"u}nf Schulen {\"u}ber drei Zeitpunkte dazu befragt, wie die Planung, Entwicklung und Implementation der Schulentwicklungsprojekte erfolgten. Die Befunde der Evaluation deuten insgesamt darauf hin, dass die Qualit{\"a}t der Werkstatt „Schule leiten" als Gesamtprogramm sowie die einzelnen Angebote der Werkstatt sehr positiv bewertet werden. Dabei nehmen die Teilnehmenden von Durchgang 2 die Werkstatt in einer Reihe von Merkmalen positiver wahr als die Teilnehmenden von Durchgang 3. Weiterhin deuten die Ergebnisse darauf hin, dass sich bestimmte Facetten des F{\"u}hrungshandelns der Teilnehmenden im zeitlichen Verlauf positiv ver{\"a}ndert haben. Hierf{\"u}r existieren Hinweise sowohl aus Perspektive der Teilnehmenden selbst als auch aus Perspektive der Lehrkr{\"a}fte ihrer Schulen. Motivationale Merkmale der Teilnehmenden sowie Aspekte des F{\"u}hrungshandelns, die sich auf T{\"a}tigkeiten zur Unterst{\"u}tzung der innerschulischen Kooperation beziehen, bleiben aus Perspektive der Teilnehmenden hingegen weitestgehend konstant. Hinsichtlich der Ver{\"a}nderungen schulischer Strukturen zur Schulentwicklung deuten die Ergebnisse auf eine positive Entwicklung der wahrgenommenen Offenheit gegen{\"u}ber Kooperation im Kollegium aus Perspektive der Lehrkr{\"a}fte hin. Die Befunde der qualitativen Begleitstudie liefern weitere Informationen {\"u}ber die wahrgenommene Qualit{\"a}t der Werkstatt sowie {\"u}ber Ver{\"a}nderungen aufseiten der Teilnehmenden und der schulischen Strukturen.},
  language  = {de}
}
@article{GuggenbergerChechkinMetzler2022,
  author    = {Guggenberger, Tobias and Chechkin, Aleksei and Metzler, Ralf},
  title     = {Absence of stationary states and non-Boltzmann distributions of fractional Brownian motion in shallow external potentials},
  series = {New journal of physics : the open-access journal for physics},
  volume    = {24},
  journal   = {New journal of physics : the open-access journal for physics},
  number    = {7},
  publisher = {Dt. Physikalische Ges.},
  address   = {[Bad Honnef]},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ac7b3c},
  pages     = {18},
  year      = {2022},
  abstract  = {We study the diffusive motion of a particle in a subharmonic potential of the form U(x) = |x|( c ) (0 < c < 2) driven by long-range correlated, stationary fractional Gaussian noise xi ( alpha )(t) with 0 < alpha <= 2. In the absence of the potential the particle exhibits free fractional Brownian motion with anomalous diffusion exponent alpha. While for an harmonic external potential the dynamics converges to a Gaussian stationary state, from extensive numerical analysis we here demonstrate that stationary states for shallower than harmonic potentials exist only as long as the relation c > 2(1 - 1/alpha) holds. We analyse the motion in terms of the mean squared displacement and (when it exists) the stationary probability density function. Moreover we discuss analogies of non-stationarity of Levy flights in shallow external potentials.},
  language  = {en}
}
@article{Kulawiak2021,
  author    = {Kulawiak, Pawel R.},
  title     = {Academic benefits of wearing noise-cancelling headphones during class for typically developing students and students with special needs},
  series = {Cogent education},
  volume    = {8},
  journal   = {Cogent education},
  number    = {1},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {2331-186X},
  doi       = {10.1080/2331186X.2021.1957530},
  pages     = {21},
  year      = {2021},
  abstract  = {Classroom noise impairs students' cognition and learning. At a first glance, it seems useful to prevent the negative effects of noise on academic learning by wearing noise-cancelling (NC) headphones during class. The literature and guidelines emphasize the academic benefits of wearing NC headphones (decreased auditory distraction, increased concentration, learning improvement, and decreased distress). These benefits are particularly expected for students with special needs. None of the recommendations to wear NC headphones during class refer to any empirical studies, indicating a potential research gap and lack of evidence. Therefore, the question arises: Is there any empirical evidence supporting academic benefits of wearing NC headphones during class for typically developing students or students with special needs? A total of 13 empirical studies (quantitative and qualitative) were identified through a systematic scoping review of the existing literature. A wide range of outcomes (cognition, learning, academic performance, behaviour, and emotions) were reported related to the use of NC headphones. Most of the studies refer to specific groups of students with special needs (learning disabilities, autism, ADHD, etc.). In view of the limited number of studies, small sample sizes, and lack of replication studies, all studies give the impression of being pilot studies on the academic benefits of wearing NC headphones. The practice of wearing NC headphones during class is an understudied topic. The current body of evidence does not meet the standards for evidence-based practices in both general and special education. Implications for educational practice and future research are discussed.},
  language  = {en}
}
@article{GoeldelKamrathMindenetal.2022,
  author    = {G{\"o}ldel, Julia Marlen and Kamrath, Clemens and Minden, Kirsten and Wiegand, Susanna and Lanzinger, Stefanie and Sengler, Claudia and Weihrauch-Bl{\"u}her, Susann and Holl, Reinhard and Tittel, Sascha Ren{\´e} and Warschburger, Petra},
  title     = {Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany},
  series = {Children},
  volume    = {10},
  journal   = {Children},
  edition   = {1},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9067},
  doi       = {10.3390/children10010010},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {This study examines the access to healthcare for children and adolescents with three common chronic diseases (type-1 diabetes (T1D), obesity, or juvenile idiopathic arthritis (JIA)) within the 4th (Delta), 5th (Omicron), and beginning of the 6th (Omicron) wave (June 2021 until July 2022) of the COVID-19 pandemic in Germany in a cross-sectional study using three national patient registries. A paper-and-pencil questionnaire was given to parents of pediatric patients (<21 years) during the routine check-ups. The questionnaire contains self-constructed items assessing the frequency of healthcare appointments and cancellations, remote healthcare, and satisfaction with healthcare. In total, 905 parents participated in the T1D-sample, 175 in the obesity-sample, and 786 in the JIA-sample. In general, satisfaction with healthcare (scale: 0-10; 10 reflecting the highest satisfaction) was quite high (median values: T1D 10, JIA 10, obesity 8.5). The proportion of children and adolescents with canceled appointments was relatively small (T1D 14.1\%, JIA 11.1\%, obesity 20\%), with a median of 1 missed appointment, respectively. Only a few parents (T1D 8.6\%; obesity 13.1\%; JIA 5\%) reported obstacles regarding health services during the pandemic. To conclude, it seems that access to healthcare was largely preserved for children and adolescents with chronic health conditions during the COVID-19 pandemic in Germany.},
  language  = {en}
}
@article{GrafMorenodelasHerasRuizetal.2018,
  author    = {Graf, Lukas and Moreno-de-las-Heras, Mariano and Ruiz, Maurici and Calsamiglia, Aleix and Garc{\´i}a-Comendador, Juli{\´a}n and Fortesa, Josep and L{\´o}pez-Taraz{\´o}n, Jos{\´e} A. and Estrany, Joan},
  title     = {Accuracy assessment of digital terrain model dataset sources for hydrogeomorphological modelling in small mediterranean catchments},
  series = {Remote sensing},
  volume    = {10},
  journal   = {Remote sensing},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-4292},
  doi       = {10.3390/rs10122014},
  pages     = {26},
  year      = {2018},
  abstract  = {Digital terrain models (DTMs) are a fundamental source of information in Earth sciences. DTM-based studies, however, can contain remarkable biases if limitations and inaccuracies in these models are disregarded. In this work, four freely available datasets, including Shuttle Radar Topography Mission C-Band Synthetic Aperture Radar (SRTM C-SAR V3 DEM), Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Map (ASTER GDEM V2), and two nationwide airborne light detection and ranging (LiDAR)-derived DTMs (at 5-m and 1-m spatial resolution, respectively) were analysed in three geomorphologically contrasting, small (3-5 km2) catchments located in Mediterranean landscapes under intensive human influence (Mallorca Island, Spain). Vertical accuracy as well as the influence of each dataset's characteristics on hydrological and geomorphological modelling applicability were assessed by using ground-truth data, classic geometric and morphometric parameters, and a recently proposed index of sediment connectivity. Overall vertical accuracy—expressed as the root mean squared error (RMSE) and normalised median deviation (NMAD)—revealed the highest accuracy for the 1-m (RMSE = 1.55 m; NMAD = 0.44 m) and 5-m LiDAR DTMs (RMSE = 1.73 m; NMAD = 0.84 m). Vertical accuracy of the SRTM data was lower (RMSE = 6.98 m; NMAD = 5.27 m), but considerably higher than for the ASTER data (RMSE = 16.10 m; NMAD = 11.23 m). All datasets were affected by systematic distortions. Propagation of these errors and coarse horizontal resolution caused negative impacts on flow routing, stream network, and catchment delineation, and to a lower extent, on the distribution of slope values. These limitations should be carefully considered when applying DTMs for catchment hydrogeomorphological modelling.},
  language  = {en}
}
@article{LangBohnBhatetal.2020,
  author    = {Lang, Judith and Bohn, Patrick and Bhat, Hilal and Jastrow, Holger and Walkenfort, Bernd and Cansiz, Feyza and Fink, Julian and Bauer, Michael and Schumacher, Fabian and Kleuser, Burkhard and Lang, Karl S.},
  title     = {Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease},
  series = {Nature Communications},
  volume    = {11},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature Publishing Group UK},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-020-15072-8},
  pages     = {1 -- 15},
  year      = {2020},
  abstract  = {Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs). In MVBs, acid ceramidase (aCDase) converts ceramide into sphingosine and increases the formation of sphingosine-rich intraluminal vesicles (ILVs). Once HSV-1 particles reach MVBs, sphingosine-rich ILVs bind to HSV-1 particles, which restricts fusion with the limiting endosomal membrane and prevents cellular infection. Lack of aCDase in macrophage cultures or in Asah1(-/-) mice results in replication of HSV-1 and Asah1(-/-) mice die soon after systemic or intravaginal inoculation. The treatment of macrophages with sphingosine enhancing compounds blocks HSV-1 propagation, suggesting a therapeutic potential of this pathway. In conclusion, aCDase loads ILVs with sphingosine, which prevents HSV-1 capsids from penetrating into the cytosol.},
  language  = {en}
}
@article{BeckmannBeckerKadowetal.2019,
  author    = {Beckmann, Nadine and Becker, Katrin Anne and Kadow, Stephanie and Schumacher, Fabian and Kramer, Melanie and Kuehn, Claudine and Schulz-Schaeffer, Walter J. and Edwards, Michael J. and Kleuser, Burkhard and Gulbins, Erich and Carpinteiro, Alexander},
  title     = {Acid Sphingomyelinase Deficiency Ameliorates Farber Disease},
  series = {International journal of molecular sciences},
  volume    = {20},
  journal   = {International journal of molecular sciences},
  number    = {24},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms20246253},
  pages     = {18},
  year      = {2019},
  abstract  = {Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can't achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients.},
  language  = {en}
}
@article{OmaneHoehle2020,
  author    = {Omane, Paul Okyere and H{\"o}hle, Barbara},
  title     = {Acquiring syntactic variability},
  series = {Frontiers in communication},
  volume    = {2021},
  journal   = {Frontiers in communication},
  publisher = {Frontiers Media},
  address   = {Lausanne, Schweiz},
  issn      = {2297-900X},
  doi       = {10.3389/fcomm.2021.604951},
  pages     = {15},
  year      = {2020},
  abstract  = {This paper investigates the predictions of the Derivational Complexity Hypothesis by studying the acquisition of wh-questions in 4- and 5-year-old Akan-speaking children in an experimental approach using an elicited production and an elicited imitation task. Akan has two types of wh-question structures (wh-in-situ and wh-ex-situ questions), which allows an investigation of children's acquisition of these two question structures and their preferences for one or the other. Our results show that adults prefer to use wh-ex-situ questions over wh-in-situ questions. The results from the children show that both age groups have the two question structures in their linguistic repertoire. However, they differ in their preferences in usage in the elicited production task: while the 5-year-olds preferred the wh-in-situ structure over the wh-ex-situ structure, the 4-year-olds showed a selective preference for the wh-in-situ structure in who-questions. These findings suggest a developmental change in wh-question preferences in Akan-learning children between 4 and 5 years of age with a so far unobserved u-shaped developmental pattern. In the elicited imitation task, all groups showed a strong tendency to maintain the structure of in-situ and ex-situ questions in repeating grammatical questions. When repairing ungrammatical ex-situ questions, structural changes to grammatical in-situ questions were hardly observed but the insertion of missing morphemes while keeping the ex-situ structure. Together, our findings provide only partial support for the Derivational Complexity Hypothesis.},
  language  = {en}
}
@article{KrauseGrosseDetersBaumannetal.2022,
  author    = {Krause, Hannes-Vincent and Große Deters, Fenne and Baumann, Annika and Krasnova, Hanna},
  title     = {Active social media use and its impact on well-being},
  series = {Journal of computer-mediated communication : a journal of the International Communication Association},
  volume    = {28},
  journal   = {Journal of computer-mediated communication : a journal of the International Communication Association},
  number    = {1},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {1083-6101},
  doi       = {10.1093/jcmc/zmac037},
  pages     = {12},
  year      = {2022},
  abstract  = {Active use of social networking sites (SNSs) has long been assumed to benefit users' well-being. However, this established hypothesis is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with considerable heterogeneity among existing studies on the hypothesis and causal evidence still limited, a final verdict on its robustness is still pending. To contribute to this ongoing debate, we conducted a week-long randomized control trial with N = 381 adult Instagram users recruited via Prolific. Specifically, we tested how active SNS use, operationalized as picture postings on Instagram, affects different dimensions of well-being. The results depicted a positive effect on users' positive affect but null findings for other well-being outcomes. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs. <br /> Lay Summary Active use of social networking sites (SNSs) has long been assumed to benefit users' well-being. However, this established assumption is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with great diversity among conducted studies on the hypothesis and a lack of causal evidence, a final verdict on its viability is still pending. To contribute to this ongoing debate, we conducted a week-long experimental investigation with 381 adult Instagram users. Specifically, we tested how posting pictures on Instagram affects different aspects of well-being. The results of this study depicted a positive effect of posting Instagram pictures on users' experienced positive emotions but no effects on other aspects of well-being. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs on users.},
  language  = {en}
}
@article{JansenKolesnikov2020,
  author    = {Jansen, Sabine and Kolesnikov, Leonid},
  title     = {Activity expansions for Gibbs correlation functions},
  series = {Lectures in pure and applied mathematics},
  journal   = {Lectures in pure and applied mathematics},
  number    = {6},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-485-2},
  issn      = {2199-4951},
  doi       = {10.25932/publishup-47212},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472121},
  pages     = {145 -- 154},
  year      = {2020},
  language  = {en}
}
@article{HammamiChaabeneKharratetal.2021,
  author    = {Hammami, Raouf and Chaabene, Helmi and Kharrat, Fatma and Werfelli, Hanen and Duncan, Michael and Rebai, Haithem and Granacher, Urs},
  title     = {Acute effects of different balance exercise types on selected measures of physical fitness in youth female volleyball players},
  series = {BMC Sports Science, Medicine and Rehabilitation},
  volume    = {13},
  journal   = {BMC Sports Science, Medicine and Rehabilitation},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1758-2555},
  doi       = {10.1186/s13102-021-00249-5},
  pages     = {8},
  year      = {2021},
  abstract  = {Background Earlier studies have shown that balance training (BT) has the potential to induce performance enhancements in selected components of physical fitness (i.e., balance, muscle strength, power, speed). While there is ample evidence on the long-term effects of BT on components of physical fitness in youth, less is known on the short-term or acute effects of single BT sessions on selected measures of physical fitness. Objective To examine the acute effects of different balance exercise types on balance, change-of-direction (CoD) speed, and jump performance in youth female volleyball players. Methods Eleven female players aged 14 years participated in this study. Three types of balance exercises (i.e., anterior, posterolateral, rotational type) were conducted in randomized order. For each exercise, 3 sets including 5 repetitions were performed. Before and after the performance of the balance exercises, participants were tested for their static balance (center of pressure surface area [CoP SA] and velocity [CoP V]) on foam and firm surfaces, CoD speed (T-Half test), and vertical jump height (countermovement jump [CMJ] height). A 3 (condition: anterior, mediolateral, rotational balance exercise type) × 2 (time: pre, post) analysis of variance was computed with repeated measures on time. Results Findings showed no significant condition × time interactions for all outcome measures (p > 0.05). However, there were small main effects of time for CoP SA on firm and foam surfaces (both d = 0.38; all p < 0.05) with no effect for CoP V on both surface conditions (p > 0.05). For CoD speed, findings showed a large main effect of time (d = 0.91; p < 0.001). However, for CMJ height, no main effect of time was observed (p > 0.05). Conclusions Overall, our results indicated small-to-large changes in balance and CoD speed performances but not in CMJ height in youth female volleyball players, regardless of the balance exercise type. Accordingly, it is recommended to regularly integrate balance exercises before the performance of sport-specific training to optimize performance development in youth female volleyball players.},
  language  = {en}
}
@article{WerfelliHammamiSelmietal.2021,
  author    = {Werfelli, Hanen and Hammami, Raouf and Selmi, Mohamed Amine and Selmi, Walid and Gabrilo, Goran and Clark, Cain C. T. and Duncan, Michael and Sekulic, Damir and Granacher, Urs and Rebai, Haithem},
  title     = {Acute Effects of Different Plyometric and Strength Exercises on Balance Performance in Youth Weightlifters},
  series = {Frontiers in Physiology},
  volume    = {12},
  journal   = {Frontiers in Physiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2021.716981},
  pages     = {9},
  year      = {2021},
  abstract  = {Background: High-intensity muscle actions have the potential to temporarily improve the performance which has been denoted as postactivation performance enhancement. Objectives: This study determined the acute effects of different stretch-shortening (fast vs. low) and strength (dynamic vs. isometric) exercises executed during one training session on subsequent balance performance in youth weightlifters. Materials and Methods: Sixteen male and female young weightlifters, aged 11.3±0.6years, performed four strength exercise conditions in randomized order, including dynamic strength (DYN; 3 sets of 3 repetitions of 10 RM) and isometric strength exercises (ISOM; 3 sets of maintaining 3s of 10 RM of back-squat), as well as fast (FSSC; 3 sets of 3 repetitions of 20-cm drop-jumps) and slow (SSSC; 3 sets of 3 hurdle jumps over a 20-cm obstacle) stretch-shortening cycle protocols. Balance performance was tested before and after each of the four exercise conditions in bipedal stance on an unstable surface (i.e., BOSU ball with flat side facing up) using two dependent variables, i.e., center of pressure surface area (CoP SA) and velocity (CoP V). Results: There was a significant effect of time on CoP SA and CoP V [F(1,60)=54.37, d=1.88, p<0.0001; F(1,60)=9.07, d=0.77, p=0.003]. In addition, a statistically significant effect of condition on CoP SA and CoP V [F(3,60)=11.81, d=1.53, p<0.0001; F(3,60)=7.36, d=1.21, p=0.0003] was observed. Statistically significant condition-by-time interactions were found for the balance parameters CoP SA (p<0.003, d=0.54) and CoP V (p<0.002, d=0.70). Specific to contrast analysis, all specified hypotheses were tested and demonstrated that FSSC yielded significantly greater improvements than all other conditions in CoP SA and CoP V [p<0.0001 (d=1.55); p=0.0004 (d=1.19), respectively]. In addition, FSSC yielded significantly greater improvements compared with the two conditions for both balance parameters [p<0.0001 (d=2.03); p<0.0001 (d=1.45)]. Conclusion: Fast stretch-shortening cycle exercises appear to be more effective to improve short-term balance performance in young weightlifters. Due to the importance of balance for overall competitive achievement in weightlifting, it is recommended that young weightlifters implement dynamic plyometric exercises in the fast stretch-shortening cycle during the warm-up to improve their balance performance.},
  language  = {en}
}
@article{DellepianeVaidJaladankietal.2021,
  author    = {Dellepiane, Sergio and Vaid, Akhil and Jaladanki, Suraj K. and Coca, Steven and Fayad, Zahi A. and Charney, Alexander W. and B{\"o}ttinger, Erwin and He, John Cijiang and Glicksberg, Benjamin S. and Chan, Lili and Nadkarni, Girish},
  title     = {Acute kidney injury in patients hospitalized with COVID-19 in New York City},
  series = {Kidney medicine},
  volume    = {3},
  journal   = {Kidney medicine},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2590-0595},
  doi       = {10.1016/j.xkme.2021.06.008},
  pages     = {877 -- 879},
  year      = {2021},
  language  = {en}
}
@article{WillnerLevermannZhaoetal.2018,
  author    = {Willner, Sven N. and Levermann, Anders and Zhao, Fang and Frieler, Katja},
  title     = {Adaptation required to preserve future high-end river flood risk at present levels},
  series = {Science Advances},
  volume    = {4},
  journal   = {Science Advances},
  number    = {1},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {2375-2548},
  doi       = {10.1126/sciadv.aao1914},
  pages     = {8},
  year      = {2018},
  abstract  = {Earth's surface temperature will continue to rise for another 20 to 30 years even with the strongest carbon emission reduction currently considered. The associated changes in rainfall patterns can result in an increased flood risk worldwide. We compute the required increase in flood protection to keep high-end fluvial flood risk at present levels. The analysis is carried out worldwide for subnational administrative units. Most of the United States, Central Europe, and Northeast and West Africa, as well as large parts of India and Indonesia, require the strongest adaptation effort. More than half of the United States needs to at least double their protection within the next two decades. Thus, the need for adaptation to increased river flood is a global problem affecting industrialized regions as much as developing countries.},
  language  = {en}
}
@article{WutzlerHudsonThieken2022,
  author    = {Wutzler, Bianca and Hudson, Paul and Thieken, Annegret},
  title     = {Adaptation strategies of flood-damaged businesses in Germany},
  series = {Frontiers in water},
  volume    = {4},
  journal   = {Frontiers in water},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2624-9375},
  doi       = {10.3389/frwa.2022.932061},
  pages     = {13},
  year      = {2022},
  abstract  = {Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication.},
  language  = {en}
}
@article{WutzlerHudsonThieken2022,
  author    = {Wutzler, Bianca and Hudson, Paul and Thieken, Annegret},
  title     = {Adaptation strategies of flood-damaged businesses in Germany},
  series = {Frontiers in Water},
  journal   = {Frontiers in Water},
  publisher = {Frontiers Media SA},
  address   = {Lausanne, Schweiz},
  issn      = {2624-9375},
  doi       = {10.3389/frwa.2022.932061},
  pages     = {13},
  year      = {2022},
  abstract  = {Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication.},
  language  = {en}
}
@article{KreibichDiBaldassarreVorogushynetal.2017,
  author    = {Kreibich, Heidi and Di Baldassarre, Giuliano and Vorogushyn, Sergiy and Aerts, Jeroen C. J. H. and Apel, Heiko and Aronica, Giuseppe T. and Arnbjerg-Nielsen, Karsten and Bouwer, Laurens M. and Bubeck, Philip and Caloiero, Tommaso and Chinh, Do T. and Cortes, Maria and Gain, Animesh K. and Giampa, Vincenzo and Kuhlicke, Christian and Kundzewicz, Zbigniew W. and Llasat, Maria Carmen and Mard, Johanna and Matczak, Piotr and Mazzoleni, Maurizio and Molinari, Daniela and Dung, Nguyen V. and Petrucci, Olga and Schr{\"o}ter, Kai and Slager, Kymo and Thieken, Annegret and Ward, Philip J. and Merz, Bruno},
  title     = {Adaptation to flood risk},
  series = {Earth's Future},
  volume    = {5},
  journal   = {Earth's Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000606},
  pages     = {953 -- 965},
  year      = {2017},
  abstract  = {As flood impacts are increasing in large parts of the world, understanding the primary drivers of changes in risk is essential for effective adaptation. To gain more knowledge on the basis of empirical case studies, we analyze eight paired floods, that is, consecutive flood events that occurred in the same region, with the second flood causing significantly lower damage. These success stories of risk reduction were selected across different socioeconomic and hydro-climatic contexts. The potential of societies to adapt is uncovered by describing triggered societal changes, as well as formal measures and spontaneous processes that reduced flood risk. This novel approach has the potential to build the basis for an international data collection and analysis effort to better understand and attribute changes in risk due to hydrological extremes in the framework of the IAHSs Panta Rhei initiative. Across all case studies, we find that lower damage caused by the second event was mainly due to significant reductions in vulnerability, for example, via raised risk awareness, preparedness, and improvements of organizational emergency management. Thus, vulnerability reduction plays an essential role for successful adaptation. Our work shows that there is a high potential to adapt, but there remains the challenge to stimulate measures that reduce vulnerability and risk in periods in which extreme events do not occur.},
  language  = {en}
}
@article{PrieskeChaabeneMoranetal.2022,
  author    = {Prieske, Olaf and Chaabene, Helmi and Moran, Jason and Saeterbakken, Atle Hole},
  title     = {Adaptations to Advanced Resistance Training Strategies in Youth and Adult Athletes},
  series = {Frontiers in physiology / Frontiers Research Foundation},
  volume    = {13},
  journal   = {Frontiers in physiology / Frontiers Research Foundation},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2022.888118},
  pages     = {3},
  year      = {2022},
  language  = {en}
}
@article{OpelNetzerDesel2023,
  author    = {Opel, Simone and Netzer, Cajus Marian and Desel, J{\"o}rg},
  title     = {Adaption von Lernwegen in adaptierten Lehrmaterialien f{\"u}r Studierende mit Berufsausbildungsabschluss},
  series = {Hochschuldidaktik Informatik HDI 2021 (Commentarii informaticae didacticae)},
  journal   = {Hochschuldidaktik Informatik HDI 2021 (Commentarii informaticae didacticae)},
  number    = {13},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-548-4},
  issn      = {1868-0844},
  doi       = {10.25932/publishup-61418},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-614188},
  pages     = {91 -- 114},
  year      = {2023},
  abstract  = {Obwohl immer mehr Menschen nicht direkt ein Studium aufnehmen, sondern zuvor eine berufliche Ausbildung absolvieren, werden die in der Ausbildung erworbenen Kompetenzen von den Hochschulen inhaltlich und didaktisch meist ignoriert. Ein Ansatz, diese Kompetenzen zu w{\"u}rdigen, ist die formale Anrechnung von mitgebrachten Kompetenzen als (f{\"u}r den Studienabschluss erforderliche) Leistungspunkte. Eine andere Variante ist der Einsatz von speziell f{\"u}r die Zielgruppe der Studierenden mit Vorkenntnissen adaptiertem Lehr-Lernmaterial. Um dar{\"u}ber hinaus individuelle Unterschiede zu ber{\"u}cksichtigen, erlaubt eine weitere Adaption individueller Lernpfade den Lernenden, genau die jeweils fehlenden Kompetenzen zu erwerben. In diesem Beitrag stellen wir die exemplarische Entwicklung derartigen Materials anhand des Kurses „Datenbanken" f{\"u}r die Zielgruppe der Studierenden mit einer abgeschlossenen Ausbildung zum Fachinformatiker bzw. zur Fachinformatikerin vor.},
  language  = {de}
}
@article{RomeroMujalliRochowKahletal.2021,
  author    = {Romero-Mujalli, Daniel and Rochow, Markus and Kahl, Sandra M. and Paraskevopoulou, Sofia and Folkertsma, Remco and Jeltsch, Florian and Tiedemann, Ralph},
  title     = {Adaptive and nonadaptive plasticity in changing environments: Implications for sexual species with different life history strategies},
  series = {Ecology and Evolution},
  volume    = {11},
  journal   = {Ecology and Evolution},
  number    = {11},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {New Jersey},
  issn      = {2045-7758},
  pages     = {17},
  year      = {2021},
  abstract  = {Populations adapt to novel environmental conditions by genetic changes or phenotypic plasticity. Plastic responses are generally faster and can buffer fitness losses under variable conditions. Plasticity is typically modeled as random noise and linear reaction norms that assume simple one-to- one genotype-phenotype maps and no limits to the phenotypic response. Most studies on plasticity have focused on its effect on population viability. However, it is not clear, whether the advantage of plasticity depends solely on environmental fluctuations or also on the genetic and demographic properties (life histories) of populations. Here we present an individual-based model and study the relative importance of adaptive and nonadaptive plasticity for populations of sexual species with different life histories experiencing directional stochastic climate change. Environmental fluctuations were simulated using differentially autocorrelated climatic stochasticity or noise color, and scenarios of directiona climate change. Nonadaptive plasticity was simulated as a random environmental effect on trait development, while adaptive plasticity as a linear, saturating, or sinusoidal reaction norm. The last two imposed limits to the plastic response and emphasized flexible interactions of the genotype with the environment. Interestingly, this assumption led to (a) smaller phenotypic than genotypic variance in the population (many-to- one genotype-phenotype map) and the coexistence of polymorphisms, and (b) the maintenance of higher genetic variation—compared to linear reaction norms and genetic determinism—even when the population was exposed to a constant environment for several generations. Limits to plasticity led to genetic accommodation, when costs were negligible, and to the appearance of cryptic variation when limits were exceeded. We found that adaptive plasticity promoted population persistence under red environmental noise and was particularly important for life histories with low fecundity. Populations produing more offspring could cope with environmental fluctuations solely by genetic changes or random plasticity, unless environmental change was too fast.},
  language  = {en}
}
@article{SchaeferDechBittmann2021,
  author    = {Schaefer, Laura and Dech, Silas and Bittmann, Frank},
  title     = {Adaptive force and emotionally related imaginations},
  series = {Heliyon},
  volume    = {7},
  journal   = {Heliyon},
  number    = {8},
  publisher = {Elsevier},
  address   = {London},
  issn      = {2405-8440},
  doi       = {10.1016/j.heliyon.2021.e07827},
  pages     = {13},
  year      = {2021},
  abstract  = {The link between emotions and motor control has been discussed for years. The measurement of the Adaptive Force (AF) provides the possibility to get insights into the adaptive control of the neuromuscular system in reaction to external forces. It was hypothesized that the holding isometric AF is especially vulnerable to disturbing inputs. Here, the behavior of the AF under the influence of positive (tasty) vs. negative (disgusting) food imaginations was investigated. The AF was examined in n = 12 cases using an objectified manual muscle test of the hip flexors, elbow flexors or pectoralis major muscle, performed by one of two experienced testers while the participants imagined their most tasty or most disgusting food. The reaction force and the limb position were measured by a handheld device. While the slope of force rises and the maximal AF did not differ significantly between tasty and disgusting imaginations (p > 0.05), the maximal isometric AF was significantly lower and the AF at the onset of oscillations was significantly higher under disgusting vs. tasty imaginations (both p = 0.001). A proper length tension control of muscles seems to be a crucial functional parameter of the neuromuscular system which can be impaired instantaneously by emotionally related negative imaginations. This might be a potential approach to evaluate somatic reactions to emotions.},
  language  = {en}
}