@article{LaemkeBaeurle2017,
  author    = {L{\"a}mke, J{\"o}rn and B{\"a}urle, Isabel},
  title     = {Epigenetic and chromatin-based mechanisms in environmental stress adaptation and stress memory in plants},
  series = {Genome biology : biology for the post-genomic era},
  volume    = {18},
  journal   = {Genome biology : biology for the post-genomic era},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1474-760X},
  doi       = {10.1186/s13059-017-1263-6},
  pages     = {8685 -- 8693},
  year      = {2017},
  abstract  = {Plants frequently have to weather both biotic and abiotic stressors, and have evolved sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications, nucleosome positioning, and DNA methylation have been recognized as important components in these adaptations. Given their potential epigenetic nature, such modifications may provide a mechanistic basis for a stress memory, enabling plants to respond more efficiently to recurring stress or even to prepare their offspring for potential future assaults. In this review, we discuss both the involvement of chromatin in stress responses and the current evidence on somatic, intergenerational, and transgenerational stress memory.},
  language  = {en}
}
@misc{HussBookhagenHuggeletal.2017,
  author    = {Huss, Matthias and Bookhagen, Bodo and Huggel, C. and Jacobsen, Dean and Bradley, Raymond S. and Clague, J. J. and Vuille, Mathias and Buytaert, Wouter and Cayan, D. R. and Greenwood, G. and Mark, B. G. and Milner, A. M. and Weingartner, Rolf and Winder, M.},
  title     = {Toward mountains without permanent snow and ice},
  series = {Earths future},
  volume    = {5},
  journal   = {Earths future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2016EF000514},
  pages     = {418 -- 435},
  year      = {2017},
  abstract  = {The cryosphere in mountain regions is rapidly declining, a trend that is expected to accelerate over the next several decades due to anthropogenic climate change. A cascade of effects will result, extending from mountains to lowlands with associated impacts on human livelihood, economy, and ecosystems. With rising air temperatures and increased radiative forcing, glaciers will become smaller and, in some cases, disappear, the area of frozen ground will diminish, the ratio of snow to rainfall will decrease, and the timing and magnitude of both maximum and minimum streamflow will change. These changes will affect erosion rates, sediment, and nutrient flux, and the biogeochemistry of rivers and proglacial lakes, all of which influence water quality, aquatic habitat, and biotic communities. Changes in the length of the growing season will allow low-elevation plants and animals to expand their ranges upward. Slope failures due to thawing alpine permafrost, and outburst floods from glacier-and moraine-dammed lakes will threaten downstream populations.Societies even well beyond the mountains depend on meltwater from glaciers and snow for drinking water supplies, irrigation, mining, hydropower, agriculture, and recreation. Here, we review and, where possible, quantify the impacts of anticipated climate change on the alpine cryosphere, hydrosphere, and biosphere, and consider the implications for adaptation to a future of mountains without permanent snow and ice.},
  language  = {en}
}
@article{HentrichTauerEspanoletal.2017,
  author    = {Hentrich, Doreen and Tauer, Klaus and Espanol, Montserrat and Ginebra, Maria-Pau and Taubert, Andreas},
  title     = {EDTA and NTA effectively tune the mineralization of calcium phosphate from bulk aqueous solution},
  series = {Biomimetics},
  volume    = {2},
  journal   = {Biomimetics},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2313-7673},
  doi       = {10.3390/biomimetics2040024},
  pages     = {21},
  year      = {2017},
  abstract  = {This study describes the effects of nitrilotriacetic acid (NTA) and ethylenediaminotetraacetic acid (EDTA) on themineralization of calciumphosphate from bulk aqueous solution. Mineralization was performed between pH 6 and 9 and with NTA or EDTA concentrations of 0, 5, 10, and 15 mM. X-ray diffraction and infrared spectroscopy show that at low pH, mainly brushite precipitates and at higher pH, mostly hydroxyapatite forms. Both additives alter the morphology of the precipitates. Without additive, brushite precipitates as large plates. With NTA, the morphology changes to an unusual rod-like shape. With EDTA, the edges of the particles are rounded and disk-like particles form. Conductivity and pH measurements suggest that the final products form through several intermediate steps.},
  language  = {en}
}
@article{SurminskiThieken2017,
  author    = {Surminski, Swenja and Thieken, Annegret},
  title     = {Promoting flood risk reduction},
  series = {Earth's Future},
  volume    = {5},
  journal   = {Earth's Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000587},
  pages     = {979 -- 1001},
  year      = {2017},
  abstract  = {Improving society's ability to prepare for, respond to and recover from flooding requires integrated, anticipatory flood risk management (FRM). However, most countries still focus their efforts on responding to flooding events if and when they occur rather than addressing their current and future vulnerability to flooding. Flood insurance is one mechanism that could promote a more ex ante approach to risk by supporting risk reduction activities. This paper uses an adapted version of Easton's System Theory to investigate the role of insurance for FRM in Germany and England. We introduce an anticipatory FRM framework, which allows flood insurance to be considered as part of a broader policy field. We analyze if and how flood insurance can catalyze a change toward a more anticipatory approach to FRM. In particular we consider insurance's role in influencing five key components of anticipatory FRM: risk knowledge, prevention through better planning, property\&\#8208;level protection measures, structural protection and preparedness (for response). We find that in both countries FRM is still a reactive, event\&\#8208;driven process, while anticipatory FRM remains underdeveloped. Collaboration between insurers and FRM decision\&\#8208;makers has already been successful, for example in improving risk knowledge and awareness, while in other areas insurance acts as a disincentive for more risk reduction action. In both countries there is evidence that insurance can play a significant role in encouraging anticipatory FRM, but this remains underutilized. Effective collaboration between insurers and government should not be seen as a cost, but as an investment to secure future insurability through flood resilience.},
  language  = {en}
}
@article{ReilRosenfeldImholtetal.2017,
  author    = {Reil, Daniela and Rosenfeld, Ulrike M. and Imholt, Christian and Schmidt, Sabrina and Ulrich, Rainer G. and Eccard, Jana and Jacob, Jens},
  title     = {Puumala hantavirus infections in bank vole populations},
  series = {BMC ecology},
  volume    = {17},
  journal   = {BMC ecology},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1472-6785},
  doi       = {10.1186/s12898-017-0118-z},
  pages     = {13},
  year      = {2017},
  abstract  = {Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk},
  language  = {en}
}
@article{OlatunjiKolawoleOloruntolaetal.2017,
  author    = {Olatunji, Akinade S. and Kolawole, Tesleem O. and Oloruntola, Moroof and G{\"u}nter, Christina},
  title     = {Evaluation of pollution of soils and particulate matter around metal recycling factories in Southwestern Nigeria},
  series = {Journal of health and pollutuin},
  volume    = {8},
  journal   = {Journal of health and pollutuin},
  number    = {17},
  publisher = {Blacksmith Institute and Pure Earth},
  address   = {New York},
  issn      = {2156-9614},
  doi       = {10.5696/2156-9614-8.17.20},
  pages     = {20 -- 30},
  year      = {2017},
  abstract  = {Background. Metal recycling factories (MRFs) have developed rapidly in Nigeria as recycling policies have been increasingly embraced. These MRFs are point sources for introducing potentially toxic elements (PTEs) into environmental media. Objectives. The aim of this study was to determine the constituents (elemental and mineralogy) of the wastes (slag and particulate matter, (PM)) and soils around the MRFs and to determine the level of pollution within the area. Methods. Sixty samples (30 slag samples, 15 soil samples and 15 PM samples) were collected for this study. The soils, slag and PM samples were analyzed for elemental constituents using inductively coupled plasma optical emission spectrometry. Mineralogy of the PM was determined using scanning electron microscope-energy dispersive spectroscopy (SEM-EDS), and soil mineralogy was determined by an X-ray diffractometer (XRD). Results. The results of the soil analyses revealed the following concentrations for the selected metals in mg/kg include lead (Pb) (21.0-2399.0), zinc (Zn) (56.0-4188.0), copper (Cu) (10.0-1470.0), nickel (Ni) (6.0-215.0), chromium (Cr) (921.0-1737.0) and cadmium (Cd) (below detectable limit (Bdl)-18.1). For the slags the results were Pb (68.0-.333.0), Zn (1364.0-3062), Cu (119.0-1470.0), Ni (12.0-675.0), Cr (297-1737) and Cd (Bdl-15.8). The results in mu g/g for the metal analysis in PM were Pb (4.6-160.0), Zn (18.0-471.0), Cu (2.5-11.0), Ni (0.8-4.2), and Cr (2.5-11.0), while Cd was undetected. The slags are currently utilized for filling the foundations of buildings and roads, providing additional pathways for the introduction of PTEs into the environment from the suspended materials generated from mechanical breakdown of the slags. Conclusions. The MRFs were found to have impacted the quality of environmental media through the introduction of PTEs, impairing soil quality, in addition to PM, which can have detrimental health consequences. Further studies on the health implications of these pollutants and their impacts on human health are needed. Competing Interests. The authors declare no competing financial interests},
  language  = {en}
}
@article{PradhanCostaRybskietal.2017,
  author    = {Pradhan, Prajal and Costa, Lu{\´i}s F{\´i}l{\´i}pe Carvalho da and Rybski, Diego and Lucht, Wolfgang and Kropp, J{\"u}rgen},
  title     = {A Systematic Study of Sustainable Development Goal (SDG) Interactions},
  series = {Earths Future},
  volume    = {5},
  journal   = {Earths Future},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2328-4277},
  doi       = {10.1002/2017EF000632},
  pages     = {1169 -- 1179},
  year      = {2017},
  abstract  = {Sustainable development goals (SDGs) have set the 2030 agenda to transform our world by tackling multiple challenges humankind is facing to ensure well-being, economic prosperity, and environmental protection. In contrast to conventional development agendas focusing on a restricted set of dimensions, the SDGs provide a holistic and multidimensional view on development. Hence, interactions among the SDGs may cause diverging results. To analyze the SDG interactions we systematize the identification of synergies and trade-offs using official SDG indicator data for 227 countries. A significant positive correlation between a pair of SDG indicators is classified as a synergy while a significant negative correlation is classified as a trade-off. We rank synergies and trade-offs between SDGs pairs on global and country scales in order to identify the most frequent SDG interactions. For a given SDG, positive correlations between indicator pairs were found to outweigh the negative ones in most countries. Among SDGs the positive and negative correlations between indicator pairs allowed for the identification of particular global patterns. SDG 1 (No poverty) has synergetic relationship with most of the other goals, whereas SDG 12 (Responsible consumption and production) is the goal most commonly associated with trade-offs. The attainment of the SDG agenda will greatly depend on whether the identified synergies among the goals can be leveraged. In addition, the highlighted trade-offs, which constitute obstacles in achieving the SDGs, need to be negotiated and made structurally nonobstructive by deeper changes in the current strategies.},
  language  = {en}
}
@article{ZimmermannRaschkeEppetal.2017,
  author    = {Zimmermann, Heike Hildegard and Raschke, Elena and Epp, Laura Saskia and Stoof-Leichsenring, Kathleen Rosemarie and Schirrmeister, Lutz and Schwamborn, Georg and Herzschuh, Ulrike},
  title     = {The history of tree and shrub taxa on Bol'shoy Lyakhovsky Island (New Siberian Archipelago) since the Last Interglacial Uncovered by Sedimentary Ancient DNA and Pollen Data},
  series = {Genes},
  volume    = {8},
  journal   = {Genes},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4425},
  doi       = {10.3390/genes8100273},
  pages     = {273},
  year      = {2017},
  abstract  = {Ecosystem boundaries, such as the Arctic-Boreal treeline, are strongly coupled with climate and were spatially highly dynamic during past glacial-interglacial cycles. Only a few studies cover vegetation changes since the last interglacial, as most of the former landscapes are inundated and difficult to access. Using pollen analysis and sedimentary ancient DNA (sedaDNA) metabarcoding, we reveal vegetation changes on Bol'shoy Lyakhovsky Island since the last interglacial from permafrost sediments. Last interglacial samples depict high levels of floral diversity with the presence of trees (Larix, Picea, Populus) and shrubs (Alnus, Betula, Ribes, Cornus, Saliceae) on the currently treeless island. After the Last Glacial Maximum, Larix re-colonised the island but disappeared along with most shrub taxa. This was probably caused by Holocene sea-level rise, which led to increased oceanic conditions on the island. Additionally, we applied two newly developed larch-specific chloroplast markers to evaluate their potential for tracking past population dynamics from environmental samples. The novel markers were successfully re-sequenced and exhibited two variants of each marker in last interglacial samples. SedaDNA can track vegetation changes as well as genetic changes across geographic space through time and can improve our understanding of past processes that shape modern patterns.},
  language  = {en}
}
@article{BernacchioniGhiniCencettietal.2017,
  author    = {Bernacchioni, Caterina and Ghini, Veronica and Cencetti, Francesca and Japtok, Lukasz and Donati, Chiara and Bruni, Paola and Turano, Paola},
  title     = {NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells},
  series = {Molecular oncology / Federation of European Biochemical Societies},
  volume    = {11},
  journal   = {Molecular oncology / Federation of European Biochemical Societies},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1878-0261},
  doi       = {10.1002/1878-0261.12048},
  pages     = {517 -- 533},
  year      = {2017},
  abstract  = {Strong experimental evidence in animal and cellular models supports a pivotal role of sphingosine kinase-1 (SK1) in oncogenesis. In many human cancers, SK1 levels are upregulated and these increases are linked to poor prognosis in patients. Here, by employing untargeted NMR- based metabolomic profiling combined with functional validations, we report the crucial role of SK1 in the metabolic shift known as the Warburg effect in A2780 ovarian cancer cells. Indeed, expression of SK1 induced a high glycolytic rate, characterized by increased levels of lactate along with increased expression of the proton/monocarboxylate symporter MCT1, and decreased oxidative metabolism, associated with the accumulation of intermediates of the tricarboxylic acid cycle and reduction in CO2 production. Additionally, SK1-expressing cells displayed a significant increase in glucose uptake paralleled by GLUT3 transporter upregulation. The role of SK1 is not limited to the induction of aerobic glycolysis, affecting metabolic pathways that appear to support the biosynthesis of macromolecules. These findings highlight the role of SK1 signaling axis in cancer metabolic reprogramming, pointing out innovative strategies for cancer therapies.},
  language  = {en}
}
@article{HintscheWaljorGrossmannetal.2017,
  author    = {Hintsche, Marius and Waljor, Veronika and Grossmann, Robert and K{\"u}hn, Marco J. and Thormann, Kai M. and Peruani, Fernando and Beta, Carsten},
  title     = {A polar bundle of flagella can drive bacterial swimming by pushing, pulling, or coiling around the cell body},
  series = {Scientific reports},
  volume    = {7},
  journal   = {Scientific reports},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-16428-9},
  pages     = {10},
  year      = {2017},
  abstract  = {Bacteria swim in sequences of straight runs that are interrupted by turning events. They drive their swimming locomotion with the help of rotating helical flagella. Depending on the number of flagella and their arrangement across the cell body, different run-and-turn patterns can be observed. Here, we present fluorescence microscopy recordings showing that cells of the soil bacterium Pseudomonas putida that are decorated with a polar tuft of helical flagella, can alternate between two distinct swimming patterns. On the one hand, they can undergo a classical push-pull-push cycle that is well known from monopolarly flagellated bacteria but has not been reported for species with a polar bundle of multiple flagella. Alternatively, upon leaving the pulling mode, they can enter a third slow swimming phase, where they propel themselves with their helical bundle wrapped around the cell body. A theoretical estimate based on a random-walk model shows that the spreading of a population of swimmers is strongly enhanced when cycling through a sequence of pushing, pulling, and wrapped flagellar configurations as compared to the simple push-pull-push pattern.},
  language  = {en}
}