@article{KonakWegnerArnrich2020, author = {Konak, Orhan and Wegner, Pit and Arnrich, Bert}, title = {IMU-Based Movement Trajectory Heatmaps for Human Activity Recognition}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {24}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20247179}, pages = {15}, year = {2020}, abstract = {Recent trends in ubiquitous computing have led to a proliferation of studies that focus on human activity recognition (HAR) utilizing inertial sensor data that consist of acceleration, orientation and angular velocity. However, the performances of such approaches are limited by the amount of annotated training data, especially in fields where annotating data is highly time-consuming and requires specialized professionals, such as in healthcare. In image classification, this limitation has been mitigated by powerful oversampling techniques such as data augmentation. Using this technique, this work evaluates to what extent transforming inertial sensor data into movement trajectories and into 2D heatmap images can be advantageous for HAR when data are scarce. A convolutional long short-term memory (ConvLSTM) network that incorporates spatiotemporal correlations was used to classify the heatmap images. Evaluation was carried out on Deep Inertial Poser (DIP), a known dataset composed of inertial sensor data. The results obtained suggest that for datasets with large numbers of subjects, using state-of-the-art methods remains the best alternative. However, a performance advantage was achieved for small datasets, which is usually the case in healthcare. Moreover, movement trajectories provide a visual representation of human activities, which can help researchers to better interpret and analyze motion patterns.}, language = {en} } @article{ZhouFischerTuncaetal.2020, author = {Zhou, Lin and Fischer, Eric and Tunca, Can and Brahms, Clemens Markus and Ersoy, Cem and Granacher, Urs and Arnrich, Bert}, title = {How We Found Our IMU}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {15}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s20154090}, pages = {29}, year = {2020}, abstract = {Inertial measurement units (IMUs) are commonly used for localization or movement tracking in pervasive healthcare-related studies, and gait analysis is one of the most often studied topics using IMUs. The increasing variety of commercially available IMU devices offers convenience by combining the sensor modalities and simplifies the data collection procedures. However, selecting the most suitable IMU device for a certain use case is increasingly challenging. In this study, guidelines for IMU selection are proposed. In particular, seven IMUs were compared in terms of their specifications, data collection procedures, and raw data quality. Data collected from the IMUs were then analyzed by a gait analysis algorithm. The difference in accuracy of the calculated gait parameters between the IMUs could be used to retrace the issues in raw data, such as acceleration range or sensor calibration. Based on our algorithm, we were able to identify the best-suited IMUs for our needs. This study provides an overview of how to select the IMUs based on the area of study with concrete examples, and gives insights into the features of seven commercial IMUs using real data.}, language = {en} } @article{TrautmannZhouBrahmsetal.2021, author = {Trautmann, Justin and Zhou, Lin and Brahms, Clemens Markus and Tunca, Can and Ersoy, Cem and Granacher, Urs and Arnrich, Bert}, title = {TRIPOD}, series = {Data : open access ʻData in scienceʼ journal}, volume = {6}, journal = {Data : open access ʻData in scienceʼ journal}, number = {9}, publisher = {MDPI}, address = {Basel}, issn = {2306-5729}, doi = {10.3390/data6090095}, pages = {19}, year = {2021}, abstract = {Inertial measurement units (IMUs) enable easy to operate and low-cost data recording for gait analysis. When combined with treadmill walking, a large number of steps can be collected in a controlled environment without the need of a dedicated gait analysis laboratory. In order to evaluate existing and novel IMU-based gait analysis algorithms for treadmill walking, a reference dataset that includes IMU data as well as reliable ground truth measurements for multiple participants and walking speeds is needed. This article provides a reference dataset consisting of 15 healthy young adults who walked on a treadmill at three different speeds. Data were acquired using seven IMUs placed on the lower body, two different reference systems (Zebris FDMT-HQ and OptoGait), and two RGB cameras. Additionally, in order to validate an existing IMU-based gait analysis algorithm using the dataset, an adaptable modular data analysis pipeline was built. Our results show agreement between the pressure-sensitive Zebris and the photoelectric OptoGait system (r = 0.99), demonstrating the quality of our reference data. As a use case, the performance of an algorithm originally designed for overground walking was tested on treadmill data using the data pipeline. The accuracy of stride length and stride time estimations was comparable to that reported in other studies with overground data, indicating that the algorithm is equally applicable to treadmill data. The Python source code of the data pipeline is publicly available, and the dataset will be provided by the authors upon request, enabling future evaluations of IMU gait analysis algorithms without the need of recording new data.}, language = {en} } @article{ChromikKirstenHerdicketal.2022, author = {Chromik, Jonas and Kirsten, Kristina and Herdick, Arne and Kappattanavar, Arpita Mallikarjuna and Arnrich, Bert}, title = {SensorHub}, series = {Sensors}, volume = {22}, journal = {Sensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s22010408}, pages = {18}, year = {2022}, abstract = {Observational studies are an important tool for determining whether the findings from controlled experiments can be transferred into scenarios that are closer to subjects' real-life circumstances. A rigorous approach to observational studies involves collecting data from different sensors to comprehensively capture the situation of the subject. However, this leads to technical difficulties especially if the sensors are from different manufacturers, as multiple data collection tools have to run simultaneously. We present SensorHub, a system that can collect data from various wearable devices from different manufacturers, such as inertial measurement units, portable electrocardiographs, portable electroencephalographs, portable photoplethysmographs, and sensors for electrodermal activity. Additionally, our tool offers the possibility to include ecological momentary assessments (EMAs) in studies. Hence, SensorHub enables multimodal sensor data collection under real-world conditions and allows direct user feedback to be collected through questionnaires, enabling studies at home. In a first study with 11 participants, we successfully used SensorHub to record multiple signals with different devices and collected additional information with the help of EMAs. In addition, we evaluated SensorHub's technical capabilities in several trials with up to 21 participants recording simultaneously using multiple sensors with sampling frequencies as high as 1000 Hz. We could show that although there is a theoretical limitation to the transmissible data rate, in practice this limitation is not an issue and data loss is rare. We conclude that with modern communication protocols and with the increasingly powerful smartphones and wearables, a system like our SensorHub establishes an interoperability framework to adequately combine consumer-grade sensing hardware which enables observational studies in real life.}, language = {en} } @article{GmeinerWarschburger2020, author = {Gmeiner, Michaela Silvia and Warschburger, Petra}, title = {Intrapersonal predictors of weight bias internalization among elementary school children}, series = {BMC Pediatrics}, volume = {20}, journal = {BMC Pediatrics}, publisher = {BioMed Central}, address = {London}, issn = {1471-2431}, doi = {10.1186/s12887-020-02264-w}, pages = {9}, year = {2020}, abstract = {Background Weight-related stigmatization is a widespread problem. Particularly the internalization of weight-related stereotypes and prejudices (weight bias internalization, WBI) is related to mental and physical health impairments. To date, little is known about the risk factors of WBI. Previous studies are mainly cross-sectional and based on adult samples. As childhood is a sensitive period for the development of a healthy self-concept, we examined predictors of WBI in children. Methods The final sample included 1,463 schoolchildren (6-11 years, 51.7\% female) who took part in a prospective study consisting of three measurement waves. The first two waves delivered data on objective weight status and self-reported weight-related teasing, body dissatisfaction, relevance of one's own figure, self-esteem and depressive symptoms; WBI was measured during the third wave. To examine predictors of WBI, we ran hierarchical regression analyses and exploratory mediation analyses. Results Lower parental education level, higher child weight status, female gender, experience of teasing, higher body dissatisfaction, higher figure-relevance, and higher depression scores were found to be predictive for higher WBI scores. Body dissatisfaction (only for girls) and the relevance of one's own figure (both genders) mediated the association between self-esteem and WBI; no weight-related differences were observed. Conclusions Our study offers longitudinal evidence for variables that enable the identification of children who are at risk for WBI. Thus, the findings deliver starting points for interventions aimed at the prevention of adverse health developments that come along with WBI.}, language = {en} } @article{BouamraZouhalRateletal.2022, author = {Bouamra, Marwa and Zouhal, Hassane and Ratel, S{\´e}bastien and Makhlouf, Issam and Bezrati, Ikram and Chtara, Mokhtar and Behm, David G. and Granacher, Urs and Chaouachi, Anis}, title = {Concurrent training promotes greater gains on body composition and components of physical fitness than single-mode training (endurance or resistance) in youth with obesity}, series = {Frontiers in physiology}, volume = {13}, journal = {Frontiers in physiology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2022.869063}, pages = {16}, year = {2022}, abstract = {The prevalence of obesity in the pediatric population has become a major public health issue. Indeed, the dramatic increase of this epidemic causes multiple and harmful consequences, Physical activity, particularly physical exercise, remains to be the cornerstone of interventions against childhood obesity. Given the conflicting findings with reference to the relevant literature addressing the effects of exercise on adiposity and physical fitness outcomes in obese children and adolescents, the effect of duration-matched concurrent training (CT) [50\% resistance (RT) and 50\% high-intensity-interval-training (HIIT)] on body composition and physical fitness in obese youth remains to be elucidated. Thus, the purpose of this study was to examine the effects of 9-weeks of CT compared to RT or HIIT alone, on body composition and selected physical fitness components in healthy sedentary obese youth. Out of 73 participants, only 37; [14 males and 23 females; age 13.4 +/- 0.9 years; body-mass-index (BMI): 31.2 +/- 4.8 kg center dot m-2] were eligible and randomized into three groups: HIIT (n = 12): 3-4 setsx12 runs at 80-110\% peak velocity, with 10-s passive recovery between bouts; RT (n = 12): 6 exercises; 3-4 sets x 10 repetition maximum (RM) and CT (n = 13): 50\% serial completion of RT and HIIT. CT promoted significant greater gains compared to HIIT and RT on body composition (p < 0.01, d = large), 6-min-walking test distance (6 MWT-distance) and on 6 MWT-VO2max (p < 0.03, d = large). In addition, CT showed substantially greater improvements than HIIT in the medicine ball throw test (20.2 vs. 13.6\%, p < 0.04, d = large). On the other hand, RT exhibited significantly greater gains in relative hand grip strength (p < 0.03, d = large) and CMJ (p < 0.01, d = large) than HIIT and CT. CT promoted greater benefits for fat, body mass loss and cardiorespiratory fitness than HIIT or RT modalities. This study provides important information for practitioners and therapists on the application of effective exercise regimes with obese youth to induce significant and beneficial body composition changes. The applied CT program and the respective programming parameters in terms of exercise intensity and volume can be used by practitioners as an effective exercise treatment to fight the pandemic overweight and obesity in youth.}, language = {en} } @article{MkaouerAmaraBouguezzietal.2023, author = {Mkaouer, Bessem and Amara, Samiha and Bouguezzi, Raja and Ben Abderrahmen, Abderraouf and Chaabene, Helmi}, title = {Validity of a new sport-specific endurance test in artistic gymnastics}, series = {Frontiers in sports and active living}, volume = {5}, journal = {Frontiers in sports and active living}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2023.1159807}, pages = {8}, year = {2023}, abstract = {Introduction General and particularly sport-specific testing is an integral aspect of performance optimization in artistic gymnastics. In artistic gymnastics, however, only non-specific field tests have been used to assess endurance performance (e.g., Multistage Shuttle Run Test; Cooper's Test). Methods This study aimed to examine the validity of a new sport-specific endurance test in artistic gymnastics. Fourteen elite-level gymnasts (i.e., eight males and six females) participated in this study. The newly developed artistic gymnastics-specific endurance test (AGSET) was conducted on two different occasions seven days apart to determine its reliability. To assess the concurrent validity of AGSET, participants performed the multistage shuttle run test (MSRT). Maximum oxygen uptake (VO2max) and respiratory exchange ratio (RER) were directly assessed using a portable gas analyzer system during both protocols. Additionally, the total time maintained (TTM) during the AGSET, maximum heart rate (HRmax), maximal aerobic speed (MAS), and blood lactate concentration (BLa) during the two protocols were collected. Results The main findings indicated that all variables derived from the AGSET (i.e., VO2max, MAS, HRmax, BLa, and RER) displayed very good relative (all intraclass correlation coefficients [ICC] > 0.90) and absolute (all typical errors of measurement [TEM] < 5\%) reliability. Further, results showed that the ability of the AGSET to detect small changes in VO2max, MAS, BLa, and RER was good (smallest worthwhile change [SWC0.2] > TEM), except HRmax (SWC0.2 < TEM). Additionally, results showed a nearly perfect association between the VO2max values derived from the AGSET and MSRT (r = 0.985; coefficient of determination [R-2] = 97\%) with no statistically significant differences (p>0.05). The mean (bias) +/- 95\% limits of agreement between the two protocols were 0.28 +/- 0.55 mlminkg-1. Discussion AGSET seems to present very good reliability and concurrent validity for assessing endurance performance in elite artistic gymnastics. In addition, the newly developed protocol presents a good ability to detect small changes in performance.}, language = {en} } @article{KamaliJahanbakhshiDogaruetal.2022, author = {Kamali, Bahareh and Jahanbakhshi, Farshid and Dogaru, Diana and Dietrich, J{\"o}rg and Nendel, Claas and AghaKouchak, Amir}, title = {Probabilistic modeling of crop-yield loss risk under drought: a spatial showcase for sub-Saharan Africa}, series = {Environmental research letters}, volume = {17}, journal = {Environmental research letters}, number = {2}, publisher = {IOP Publishing}, address = {Bristol}, issn = {1748-9326}, doi = {10.1088/1748-9326/ac4ec1}, pages = {15}, year = {2022}, abstract = {Assessing the risk of yield loss in African drought-affected regions is key to identify feasible solutions for stable crop production. Recent studies have demonstrated that Copula-based probabilistic methods are well suited for such assessment owing to reasonably inferring important properties in terms of exceedance probability and joint dependence of different characterization. However, insufficient attention has been given to quantifying the probability of yield loss and determining the contribution of climatic factors. This study applies the Copula theory to describe the dependence between drought and crop yield anomalies for rainfed maize, millet, and sorghum crops in sub-Saharan Africa (SSA). The environmental policy integrated climate model, calibrated with Food and Agriculture Organization country-level yield data, was used to simulate yields across SSA (1980-2012). The results showed that the severity of yield loss due to drought had a higher magnitude than the severity of drought itself. Sensitivity analysis to identify factors contributing to drought and high-temperature stresses for all crops showed that the amount of precipitation during vegetation and grain filling was the main driver of crop yield loss, and the effect of temperature was stronger for sorghum than for maize and millet. The results demonstrate the added value of probabilistic methods for drought-impact assessment. For future studies, we recommend looking into factors influencing drought and high-temperature stresses as individual/concurrent climatic extremes.}, language = {en} } @article{BrownFanselowHalletal.2021, author = {Brown, J. M. M. and Fanselow, Gisbert and Hall, Rebecca and Kliegl, Reinhold}, title = {Middle ratings rise regardless of grammatical construction}, series = {PLOS ONE / Public Library of Science}, volume = {16}, journal = {PLOS ONE / Public Library of Science}, number = {5}, publisher = {PLOS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0251280}, pages = {26}, year = {2021}, abstract = {People perceive sentences more favourably after hearing or reading them many times. A prominent approach in linguistic theory argues that these types of exposure effects (satiation effects) show direct evidence of a generative approach to linguistic knowledge: only some sentences improve under repeated exposure, and which sentences do improve can be predicted by a model of linguistic competence that yields natural syntactic classes. However, replications of the original findings have been inconsistent, and it remains unclear whether satiation effects can be reliably induced in an experimental setting at all. Here we report four findings regarding satiation effects in wh-questions across German and English. First, the effects pertain to zone of well-formedness rather than syntactic class: all intermediate ratings, including calibrated fillers, increase at the beginning of the experimental session regardless of syntactic construction. Second, though there is satiation, ratings asymptote below maximum acceptability. Third, these effects are consistent across judgments of superiority effects in English and German. Fourth, wh-questions appear to show similar profiles in English and German, despite these languages being traditionally considered to differ strongly in whether they show effects on movement: violations of the superiority condition can be modulated to a similar degree in both languages by manipulating subject-object initiality and animacy congruency of the wh-phrase. We improve on classic satiation methods by distinguishing between two crucial tests, namely whether exposure selectively targets certain grammatical constructions or whether there is a general repeated exposure effect. We conclude that exposure effects can be reliably induced in rating experiments but exposure does not appear to selectively target certain grammatical constructions. Instead, they appear to be a phenomenon of intermediate gradient judgments.}, language = {en} } @article{GeirhosDomhardtLunkenheimeretal.2022, author = {Geirhos, Agnes and Domhardt, Matthias and Lunkenheimer, Frederike and Temming, Svenja and Holl, Reinhard and Minden, Kirsten and Warschburger, Petra and Meissner, Thomas and Mueller-Stierlin, Annabel S. and Baumeister, Harald}, title = {Feasibility and potential efficacy of a guided internet- and mobile-based CBT for adolescents and young adults with chronic medical conditions and comorbid depression or anxiety symptoms (youthCOACH(CD)): a randomized controlled pilot trial}, series = {BMC pediatrics}, volume = {22}, journal = {BMC pediatrics}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {1471-2431}, doi = {10.1186/s12887-022-03134-3}, pages = {15}, year = {2022}, abstract = {Background: Adolescents and young adults (AYA) with a chronic medical condition show an increased risk for developing mental comorbidities compared to their healthy peers. Internet- and mobile-based cognitive behavioral therapy (iCBT) might be a low-threshold treatment to support affected AYA. In this randomized controlled pilot trial, the feasibility and potential efficacy of youthCOACH(CD), an iCBT targeting symptoms of anxiety and depression in AYA with chronic medical conditions, was evaluated. Methods: A total of 30 AYA (M-age 16.13; SD= 2.34; 73\% female), aged 12-21 years either suffering from cystic fibrosis, juvenile idiopathic arthritis or type 1 diabetes, were randomly assigned to either a guided version of the iCBT youthCOACH(CD) (IC, n=15) or to a waitlist control group (CG, n=15), receiving an unguided version of the iCBT six months post-randomization. Participants of the IG and the CG were assessed before (t0), twelve weeks after (t1) and six months after (t2) randomization. Primary outcome was the feasibility of the iCBT. Different parameters of feasibility e.g. acceptance, client satisfaction or potential side effects were evaluated. First indications of the possible efficacy with regard to the primary efficacy outcome, the Patient Health Questionnaire Anxiety and Depression Scale, and further outcome variables were evaluated using linear regression models, adjusting for baseline values. Results: Regarding feasibility, intervention completion was 60\%; intervention satisfaction (M = 25.42, SD = 5.85) and perceived therapeutic alliance (M = 2.83, SD = 1.25) were moderate and comparable to other iCBTs. No patterns emerged regarding subjective and objective negative side effects due to participation in youthCOACH(CD). Estimates of potential efficacy showed between group differences, with a potential medium-term benefit of youthCOACH(CD) (beta = -0.55, 95\%Cl: -1.17; 0.07), but probably not short-term (beta = 0.20, 95\%Cl: -0.47; 0.88). Conclusions: Our results point to the feasibility of youthCOACH(CD) and the implementation of a future definitive randomized controlled trial addressing its effectiveness and cost-effectiveness. Due to the small sample size, conclusions are premature, however, further strategies to foster treatment adherence should be considered.}, language = {en} } @article{WiemkerBunovaNeufeldetal.2022, author = {Wiemker, Veronika and Bunova, Anna and Neufeld, Maria and Gornyi, Boris and Yurasova, Elena and Konigorski, Stefan and Kalinina, Anna and Kontsevaya, Anna and Ferreira-Borges, Carina and Probst, Charlotte}, title = {Pilot study to evaluate usability and acceptability of the 'Animated Alcohol Assessment Tool' in Russian primary healthcare}, series = {Digital health}, volume = {8}, journal = {Digital health}, publisher = {Sage Publications}, address = {London}, issn = {2055-2076}, doi = {10.1177/20552076211074491}, pages = {11}, year = {2022}, abstract = {Background and aims: Accurate and user-friendly assessment tools quantifying alcohol consumption are a prerequisite to effective prevention and treatment programmes, including Screening and Brief Intervention. Digital tools offer new potential in this field. We developed the 'Animated Alcohol Assessment Tool' (AAA-Tool), a mobile app providing an interactive version of the World Health Organization's Alcohol Use Disorders Identification Test (AUDIT) that facilitates the description of individual alcohol consumption via culturally informed animation features. This pilot study evaluated the Russia-specific version of the Animated Alcohol Assessment Tool with regard to (1) its usability and acceptability in a primary healthcare setting, (2) the plausibility of its alcohol consumption assessment results and (3) the adequacy of its Russia-specific vessel and beverage selection. Methods: Convenience samples of 55 patients (47\% female) and 15 healthcare practitioners (80\% female) in 2 Russian primary healthcare facilities self-administered the Animated Alcohol Assessment Tool and rated their experience on the Mobile Application Rating Scale - User Version. Usage data was automatically collected during app usage, and additional feedback on regional content was elicited in semi-structured interviews. Results: On average, patients completed the Animated Alcohol Assessment Tool in 6:38 min (SD = 2.49, range = 3.00-17.16). User satisfaction was good, with all subscale Mobile Application Rating Scale - User Version scores averaging >3 out of 5 points. A majority of patients (53\%) and practitioners (93\%) would recommend the tool to 'many people' or 'everyone'. Assessed alcohol consumption was plausible, with a low number (14\%) of logically impossible entries. Most patients reported the Animated Alcohol Assessment Tool to reflect all vessels (78\%) and all beverages (71\%) they typically used. Conclusion: High acceptability ratings by patients and healthcare practitioners, acceptable completion time, plausible alcohol usage assessment results and perceived adequacy of region-specific content underline the Animated Alcohol Assessment Tool's potential to provide a novel approach to alcohol assessment in primary healthcare. After its validation, the Animated Alcohol Assessment Tool might contribute to reducing alcohol-related harm by facilitating Screening and Brief Intervention implementation in Russia and beyond.}, language = {en} } @article{HoangGryzikHoppeetal.2022, author = {Hoang, Yen and Gryzik, Stefanie and Hoppe, Ines and Rybak, Alexander and Sch{\"a}dlich, Martin and Kadner, Isabelle and Walther, Dirk and Vera, Julio and Radbruch, Andreas and Groth, Detlef and Baumgart, Sabine and Baumgrass, Ria}, title = {PRI: Re-analysis of a public mass cytometry dataset reveals patterns of effective tumor treatments}, series = {Frontiers in immunology}, volume = {13}, journal = {Frontiers in immunology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-3224}, doi = {10.3389/fimmu.2022.849329}, pages = {9}, year = {2022}, abstract = {Recently, mass cytometry has enabled quantification of up to 50 parameters for millions of cells per sample. It remains a challenge to analyze such high-dimensional data to exploit the richness of the inherent information, even though many valuable new analysis tools have already been developed. We propose a novel algorithm "pattern recognition of immune cells (PRI)" to tackle these high-dimensional protein combinations in the data. PRI is a tool for the analysis and visualization of cytometry data based on a three or more-parametric binning approach, feature engineering of bin properties of multivariate cell data, and a pseudo-multiparametric visualization. Using a publicly available mass cytometry dataset, we proved that reproducible feature engineering and intuitive understanding of the generated bin plots are helpful hallmarks for re-analysis with PRI. In the CD4(+)T cell population analyzed, PRI revealed two bin-plot patterns (CD90/CD44/CD86 and CD90/CD44/CD27) and 20 bin plot features for threshold-independent classification of mice concerning ineffective and effective tumor treatment. In addition, PRI mapped cell subsets regarding co-expression of the proliferation marker Ki67 with two major transcription factors and further delineated a specific Th1 cell subset. All these results demonstrate the added insights that can be obtained using the non-cluster-based tool PRI for re-analyses of high-dimensional cytometric data.}, language = {en} } @article{ArnousZeckraVenerdinietal.2020, author = {Arnous, Ahmad and Zeckra, Martin and Venerdini, Agostina and Alvarado, Patricia and Arrowsmith, Ram{\´o}n and Guillemoteau, Julien and Landgraf, Angela and Guti{\´e}rrez, Adolfo Antonio and Strecker, Manfred}, title = {Neotectonic Activity in the Low-Strain Broken Foreland (Santa B{\´a}rbara System) of the North-Western Argentinean Andes (26°S)}, series = {Lithosphere}, volume = {2020}, journal = {Lithosphere}, number = {1}, publisher = {GSA}, address = {Boulder, Colo.}, issn = {1947-4253}, doi = {10.2113/2020/8888588}, pages = {1 -- 25}, year = {2020}, abstract = {Uplift in the broken Andean foreland of the Argentine Santa B{\´a}rbara System (SBS) is associated with the contractional reactivation of basement anisotropies, similar to those reported from the thick-skinned Cretaceous-Eocene Laramide province of North America. Fault scarps, deformed Quaternary deposits and landforms, disrupted drainage patterns, and medium-sized earthquakes within the SBS suggest that movement along these structures may be a recurring phenomenon, with yet to be defined repeat intervals and rupture lengths. In contrast to the Subandes thrust belt farther north, where eastward-migrating deformation has generated a well-defined thrust front, the SBS records spatiotemporally disparate deformation along structures that are only known to the first order. We present herein the results of geomorphic desktop analyses, structural field observations, and 2D electrical resistivity tomography and seismic-refraction tomography surveys and an interpretation of seismic reflection profiles across suspected fault scarps in the sedimentary basins adjacent to the Candelaria Range (CR) basement uplift, in the south-central part of the SBS. Our analysis in the CR piedmont areas reveals consistency between the results of near-surface electrical resistivity and seismic-refraction tomography surveys, the locations of prominent fault scarps, and structural geometries at greater depth imaged by seismic reflection data. We suggest that this deformation is driven by deep-seated blind thrusting beneath the CR and associated regional warping, while shortening involving Mesozoic and Cenozoic sedimentary strata in the adjacent basins was accommodated by layer-parallel folding and flexural-slip faults that cut through Quaternary landforms and deposits at the surface.}, language = {en} } @article{ArboledaZapataAngelopoulosOverduinetal.2022, author = {Arboleda-Zapata, Mauricio and Angelopoulos, Michael and Overduin, Pier Paul and Grosse, Guido and Jones, Benjamin M. and Tronicke, Jens}, title = {Exploring the capabilities of electrical resistivity tomography to study subsea permafrost}, series = {The Cryosphere}, volume = {16}, journal = {The Cryosphere}, publisher = {Copernicus}, address = {Katlenburg-Lindau}, issn = {1994-0424}, doi = {10.5194/tc-16-4423-2022}, pages = {4423 -- 4445}, year = {2022}, abstract = {Sea level rise and coastal erosion have inundated large areas of Arctic permafrost. Submergence by warm and saline waters increases the rate of inundated permafrost thaw compared to sub-aerial thawing on land. Studying the contact between the unfrozen and frozen sediments below the seabed, also known as the ice-bearing permafrost table (IBPT), provides valuable information to understand the evolution of sub-aquatic permafrost, which is key to improving and understanding coastal erosion prediction models and potential greenhouse gas emissions. In this study, we use data from 2D electrical resistivity tomography (ERT) collected in the nearshore coastal zone of two Arctic regions that differ in their environmental conditions (e.g., seawater depth and resistivity) to image and study the subsea permafrost. The inversion of 2D ERT data sets is commonly performed using deterministic approaches that favor smoothed solutions, which are typically interpreted using a user-specified resistivity threshold to identify the IBPT position. In contrast, to target the IBPT position directly during inversion, we use a layer-based model parameterization and a global optimization approach to invert our ERT data. This approach results in ensembles of layered 2D model solutions, which we use to identify the IBPT and estimate the resistivity of the unfrozen and frozen sediments, including estimates of uncertainties. Additionally, we globally invert 1D synthetic resistivity data and perform sensitivity analyses to study, in a simpler way, the correlations and influences of our model parameters. The set of methods provided in this study may help to further exploit ERT data collected in such permafrost environments as well as for the design of future field experiments.}, language = {en} } @article{WeberPutaLesinskietal.2018, author = {Weber, Stephanie and Puta, Christian and Lesinski, Melanie and Gabriel, Brunhild and Steidten, Thomas and B{\"a}r, Karl-J{\"u}rgen and Herbsleb, Marco and Granacher, Urs and Gabriel, Holger H. W.}, title = {Symptoms of anxiety and depression in young athletes using the hospital anxiety and depression scale}, series = {Frontiers in physiology}, volume = {9}, journal = {Frontiers in physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2018.00182}, pages = {12}, year = {2018}, abstract = {Elite young athletes have to cope with multiple psychological demands such as training volume, mental and physical fatigue, spatial separation of family and friends or time management problems may lead to reduced mental and physical recovery. While normative data regarding symptoms of anxiety and depression for the general population is available (Hinz and Brahler, 2011), hardly any information exists for adolescents in general and young athletes in particular. Therefore, the aim of this study was to assess overall symptoms of anxiety and depression in young athletes as well as possible sex differences. The survey was carried out within the scope of the study "Resistance Training in Young Athletes" (KINGS-Study). Between August 2015 and September 2016, 326 young athletes aged (mean +/- SD) 14.3 +/- 1.6 years completed the Hospital Anxiety and Depression Scale (HAD Scale). Regarding the analysis of age on the anxiety and depression subscales, age groups were classified as follows: late childhood (12-14 years) and late adolescence (15-18 years). The participating young athletes were recruited from Olympic weight lifting, handball, judo, track and field athletics, boxing, soccer, gymnastics, ice speed skating, volleyball, and rowing. Anxiety and depression scores were (mean +/- SD) 4.3 +/- 3.0 and 2.8 +/- 2.9, respectively. In the subscale anxiety, 22 cases (6.7\%) showed subclinical scores and 11 cases (3.4\%) showed clinical relevant score values. When analyzing the depression subscale, 31 cases (9.5\%) showed subclinical score values and 12 cases (3.7\%) showed clinically important values. No significant differences were found between male and female athletes (p >= 0.05). No statistically significant differences in the HADS scores were found between male athletes of late childhood and late adolescents (p >= 0.05). To the best of our knowledge, this is the first report describing questionnaire based indicators of symptoms of anxiety and depression in young athletes. Our data implies the need for sports medical as well as sports psychiatric support for young athletes. In addition, our results demonstrated that the chronological classification concerning age did not influence HAD Scale outcomes. Future research should focus on sports medical and sports psychiatric interventional approaches with the goal to prevent anxiety and depression as well as teaching coping strategies to young athletes.}, language = {en} } @article{WarschburgerKamrathLanzingeretal.2023, author = {Warschburger, Petra and Kamrath, Clemens and Lanzinger, Stefanie and Sengler, Claudia and Wiegand, Susanna and G{\"o}ldel, Julia Marlen and Weihrauch-Bl{\"u}her, Susann and Holl, Reinhard and Minden, Kirsten}, title = {A prospective analysis of the long-term impact of the COVID-19 pandemic on well-being and health care among children with a chronic condition and their families}, series = {BMC pediatrics}, volume = {23}, journal = {BMC pediatrics}, number = {1}, publisher = {BioMed Central}, address = {London}, issn = {1471-2431}, doi = {10.1186/s12887-023-03912-7}, pages = {15}, year = {2023}, abstract = {Background There is consistent evidence that the COVID-19 pandemic is associated with an increased psychosocial burden on children and adolescents and their parents. Relatively little is known about its particular impact on high-risk groups with chronic physical health conditions (CCs). Therefore, the primary aim of the study is to analyze the multiple impacts on health care and psychosocial well-being on these children and adolescents and their parents. Methods We will implement a two-stage approach. In the first step, parents and their underage children from three German patient registries for diabetes, obesity, and rheumatic diseases, are invited to fill out short questionnaires including questions about corona-specific stressors, the health care situation, and psychosocial well-being. In the next step, a more comprehensive, in-depth online survey is carried out in a smaller subsample. Discussion The study will provide insights into the multiple longer-term stressors during the COVID-19 pandemic in families with a child with a CC. The simultaneous consideration of medical and psycho-social endpoints will help to gain a deeper understanding of the complex interactions affecting family functioning, psychological well-being, and health care delivery.}, language = {en} } @article{ChengDennisOsuohaetal.2023, author = {Cheng, Feng and Dennis, Alice B. and Osuoha, Josephine Ijeoma and Canitz, Julia and Kirschbaum, Frank and Tiedemann, Ralph}, title = {A new genome assembly of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha}, series = {BMC genomics}, volume = {24}, journal = {BMC genomics}, number = {1}, publisher = {BMC}, address = {London}, issn = {1471-2164}, doi = {10.1186/s12864-023-09196-6}, pages = {13}, year = {2023}, abstract = {Background Teleost fishes comprise more than half of the vertebrate species. Within teleosts, most phylogenies consider the split between Osteoglossomorpha and Euteleosteomorpha/Otomorpha as basal, preceded only by the derivation of the most primitive group of teleosts, the Elopomorpha. While Osteoglossomorpha are generally species poor, the taxon contains the African weakly electric fish (Mormyroidei), which have radiated into numerous species. Within the mormyrids, the genus Campylomormyrus is mostly endemic to the Congo Basin. Campylomormyrus serves as a model to understand mechanisms of adaptive radiation and ecological speciation, especially with regard to its highly diverse species-specific electric organ discharges (EOD). Currently, there are few well-annotated genomes available for electric fish in general and mormyrids in particular. Our study aims at producing a high-quality genome assembly and to use this to examine genome evolution in relation to other teleosts. This will facilitate further understanding of the evolution of the osteoglossomorpha fish in general and of electric fish in particular. Results A high-quality weakly electric fish (C. compressirostris) genome was produced from a single individual with a genome size of 862 Mb, consisting of 1,497 contigs with an N50 of 1,399 kb and a GC-content of 43.69\%. Gene predictions identified 34,492 protein-coding genes, which is a higher number than in the two other available Osteoglossomorpha genomes of Paramormyrops kingsleyae and Scleropages formosus. A Computational Analysis of gene Family Evolution (CAFE5) comparing 33 teleost fish genomes suggests an overall faster gene family turnover rate in Osteoglossomorpha than in Otomorpha and Euteleosteomorpha. Moreover, the ratios of expanded/contracted gene family numbers in Osteoglossomorpha are significantly higher than in the other two taxa, except for species that had undergone an additional genome duplication (Cyprinus carpio and Oncorhynchus mykiss). As potassium channel proteins are hypothesized to play a key role in EOD diversity among species, we put a special focus on them, and manually curated 16 Kv1 genes. We identified a tandem duplication in the KCNA7a gene in the genome of C. compressirostris. Conclusions We present the fourth genome of an electric fish and the third well-annotated genome for Osteoglossomorpha, enabling us to compare gene family evolution among major teleost lineages. Osteoglossomorpha appear to exhibit rapid gene family evolution, with more gene family expansions than contractions. The curated Kv1 gene family showed seven gene clusters, which is more than in other analyzed fish genomes outside Osteoglossomorpha. The KCNA7a, encoding for a potassium channel central for EOD production and modulation, is tandemly duplicated which may related to the diverse EOD observed among Campylomormyrus species.}, language = {en} } @article{CescaSuganRudzinskietal.2022, author = {Cesca, Simone and Sugan, Monica and Rudzinski, Lukasz and Vajedian, Sanaz and Niemz, Peter and Plank, Simon and Petersen, Gesa and Deng, Zhiguo and Rivalta, Eleonora and Vuan, Alessandro and Linares, Milton Percy Plasencia and Heimann, Sebastian and Dahm, Torsten}, title = {Massive earthquake swarm driven by magmatic intrusion at the Bransfield Strait, Antarctica}, series = {Communications earth and environment}, volume = {3}, journal = {Communications earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-4435}, doi = {10.1038/s43247-022-00418-5}, pages = {11}, year = {2022}, abstract = {An earthquake swarm affected the Bransfield Strait, Antarctica, a unique rift basin in transition from intra-arc rifting to ocean spreading. The swarm, counting similar to 85,000 volcano-tectonic earthquakes since August 2020, is located close to the Orca submarine volcano, previously considered inactive. Simultaneously, geodetic data reported up to similar to 11 cm north-westward displacement over King George Island. We use a broad variety of geophysical data and methods to reveal the complex migration of seismicity, accompanying the intrusion of 0.26-0.56 km(3) of magma. Strike-slip earthquakes mark the intrusion at depth, while shallower normal faulting the similar to 20 km long lateral growth of a dike. Seismicity abruptly decreased after a Mw 6.0 earthquake, suggesting the magmatic dike lost pressure with the slipping of a large fault. A seafloor eruption is likely, but not confirmed by sea surface temperature anomalies. The unrest documents episodic magmatic intrusion in the Bransfield Strait, providing unique insights into active continental rifting.}, language = {en} } @article{FehrPiccininniKurthetal.2023, author = {Fehr, Jana and Piccininni, Marco and Kurth, Tobias and Konigorski, Stefan}, title = {Assessing the transportability of clinical prediction models for cognitive impairment using causal models}, series = {BMC medical research methodology}, volume = {23}, journal = {BMC medical research methodology}, number = {1}, publisher = {BMC}, address = {London}, issn = {1471-2288}, doi = {10.1186/s12874-023-02003-6}, pages = {14}, year = {2023}, abstract = {Background Machine learning models promise to support diagnostic predictions, but may not perform well in new settings. Selecting the best model for a new setting without available data is challenging. We aimed to investigate the transportability by calibration and discrimination of prediction models for cognitive impairment in simulated external settings with different distributions of demographic and clinical characteristics. Methods We mapped and quantified relationships between variables associated with cognitive impairment using causal graphs, structural equation models, and data from the ADNI study. These estimates were then used to generate datasets and evaluate prediction models with different sets of predictors. We measured transportability to external settings under guided interventions on age, APOE \& epsilon;4, and tau-protein, using performance differences between internal and external settings measured by calibration metrics and area under the receiver operating curve (AUC). Results Calibration differences indicated that models predicting with causes of the outcome were more transportable than those predicting with consequences. AUC differences indicated inconsistent trends of transportability between the different external settings. Models predicting with consequences tended to show higher AUC in the external settings compared to internal settings, while models predicting with parents or all variables showed similar AUC. Conclusions We demonstrated with a practical prediction task example that predicting with causes of the outcome results in better transportability compared to anti-causal predictions when considering calibration differences. We conclude that calibration performance is crucial when assessing model transportability to external settings.}, language = {en} } @article{WelkeSperberBergmannetal.2022, author = {Welke, Robert-William and Sperber, Hannah Sabeth and Bergmann, Ronny and Koikkarah, Amit and Menke, Laura and Sieben, Christian and Kr{\"u}ger, Detlev H. and Chiantia, Salvatore and Herrmann, Andreas and Schwarzer, Roland}, title = {Characterization of hantavirus N protein intracellular dynamics and localization}, series = {Viruses}, volume = {14}, journal = {Viruses}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {1999-4915}, doi = {10.3390/v14030457}, pages = {14}, year = {2022}, abstract = {Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome. The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation, and several other crucial processes during hantavirus infection. In this study, we generated fluorescently tagged N protein constructs derived from Puumalavirus (PUUV), the dominant hantavirus species in Central, Northern, and Eastern Europe. We comprehensively characterized this protein in the rodent cell line CHO-K1, monitoring the dynamics of N protein complex formation and investigating co-localization with host proteins as well as the viral glycoproteins Gc and Gn. We observed formation of large, fibrillar PUUV N protein aggregates, rapidly coalescing from early punctate and spike-like assemblies. Moreover, we found significant spatial correlation of N with vimentin, actin, and P-bodies but not with microtubules. N constructs also co-localized with Gn and Gc albeit not as strongly as the glycoproteins associated with each other. Finally, we assessed oligomerization of N constructs, observing efficient and concentration-dependent multimerization, with complexes comprising more than 10 individual proteins.}, language = {en} }