@article{HeisigMatthewes2022, author = {Heisig, Jan Paul and Matthewes, S{\"o}nke Hendrik}, title = {No evidence that strict educational tracking improves student performance through classroom homogeneity}, series = {Zeitschrift f{\"u}r Soziologie}, volume = {51}, journal = {Zeitschrift f{\"u}r Soziologie}, number = {1}, publisher = {de Gruyter Oldenbourg}, address = {Berlin}, issn = {0340-1804}, doi = {10.1515/zfsoz-2022-0001}, pages = {99 -- 111}, year = {2022}, abstract = {In a recent contribution to this journal, Esser and Seuring (2020) draw on data from the National Educational Panel Study to attack the widespread view that tracking in lower secondary education exacerbates inequalities in student outcomes without improving average student performance. Exploiting variation in the strictness of tracking across 13 of the 16 German federal states (e. g., whether teacher recommendations are binding), Esser and Seuring claim to demonstrate that stricter tracking after grade 4 results in better performance in grade 7 and that this can be attributed to the greater homogeneity of classrooms under strict tracking. We show these conclusions to be untenable: Esser and Seuring's measures of classroom composition are highly dubious because the number of observed students is very small for many classrooms. Even when we adopt their classroom composition measures, simple corrections and extensions of their analysis reveal that there is no meaningful evidence for a positive relationship between classroom homogeneity and student achievement - the channel supposed to mediate the alleged positive effect of strict tracking. We go on to show that students from more strictly tracking states perform better already at the start of tracking (grade 5), which casts further doubt on the alleged positive effect of strict tracking on learning progress and leaves selection or anticipation effects as more plausible explanations. On a conceptual level, we emphasize that Esser and Seuring's analysis is limited to states that implement different forms of early tracking and cannot inform us about the relative performance of comprehensive and tracked systems that is the focus of most prior research.}, language = {en} } @article{OPUS4-4948, title = {{\"U}ber die Autoren}, volume = {XI}, number = {21}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-51859}, year = {2010}, language = {de} } @article{OPUS4-6577, title = {{\"U}ber die Autoren}, volume = {XIV}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68120}, pages = {68 -- 69}, year = {2013}, language = {de} } @article{Kroeger2013, author = {Kr{\"o}ger, Bj{\"o}rn}, title = {Remarks on a scene, depicting the primeval world}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-69848}, pages = {7 -- 35}, year = {2013}, abstract = {The Prussian geologist Leopold von Buch was a lifelong friend of Alexander von Humboldt and had a significant influence on Humboldt's geological ideas. In a talk, held in Berlin in 1831, which is published here for the first time, von Buch presented the Duria Antiquior of 1830 by the English geologist Henry De La Beche. The Duria Antiquior is widely regarded as the earliest depiction of a scene of prehistoric life from deep time. The print raised new questions about the processes of geohistorical change. The talk reveals that Leopold von Buch was a true scientist of the Romantic Age. His descriptions of geohistorical organismic transformations are taken from pictorial examples of organismic transformation from the classical literature. The talk also illustrates how influential English geologists were for geo-historical reconstructions in Germany.}, language = {en} } @article{Beck2013, author = {Beck, Hanno}, title = {Das literarische Testament Alexander von Humboldts 1799}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70126}, pages = {87 -- 95}, year = {2013}, language = {de} } @article{Schmuck2013, author = {Schmuck, Thomas}, title = {Tod in den Anden}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70061}, pages = {55 -- 68}, year = {2013}, abstract = {Der Forschungsreisende Francis Hall kam als Soldat nach S{\"u}damerika und bet{\"a}tigte sich hier auch als Pflanzensammler, Reiseschriftsteller und Bergsteiger. Er war Freund und Briefpartner Jeremy Benthams und versuchte gemeinsam mit Jean-Baptiste Boussingault den Chimborazo zu besteigen. Der liberale Journalist wurde 1833 in b{\"u}rgerkriegs{\"a}hnlichen Unruhen in Ecuador ermordet. Der einzige Brief Halls an Humboldt, in dem er diesen f{\"u}r die Naturerschließung des Landes zu gewinnen versucht, eine Sammlung andiner Pflanzen {\"u}bersendet und seine Einsch{\"a}tzung zur politischen Lage und Zukunft S{\"u}damerikas kundtut, wird hier ver{\"o}ffentlicht und kommentiert.}, language = {de} } @article{Roussanova2013, author = {Roussanova, Elena}, title = {Hermann Trautschold und die Ehrung Alexander von Humboldts in Russland}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70083}, pages = {36 -- 54}, year = {2013}, abstract = {Der 100. Geburtstag von Alexander von Humboldt im Jahre 1869 wurde in Russland groß gefeiert, besonders von der Soci{\´e}t{\´e} Imp{\´e}riale des Naturalistes de Moscou. Der sp{\"a}tere Sekret{\"a}r dieser Gesellschaft, Hermann Trautschold, hielt damals eine vielbeachtete Lobrede auf den weltbekannten deutschen Naturforscher und Forschungsreisenden. Im Fokus des Aufsatzes steht der deutsch-russische Geologe und Pal{\"a}ontologe Trautschold sowie seine im Jahre 1869 in Moskau gehaltene Lobrede.}, language = {de} } @article{ThiemerSachse2013, author = {Thiemer-Sachse, Ursula}, title = {„Wir verbrachten mehr als 24 Stunden, ohne etwas anderes als Schokolade und Limonade zu uns zu nehmen"}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70106}, pages = {77 -- 83}, year = {2013}, abstract = {In Alexander von Humboldts Tageb{\"u}chern seiner ber{\"u}hmten Forschungsreise durch Spanisch-Amerika finden sich Bemerkungen und Hinweise f{\"u}r k{\"u}nftige Leser seiner Reisedarstellungen zu Problemen der Verpflegung. Zumeist werden Engp{\"a}sse und Missst{\"a}nde erw{\"a}hnt sowie Fragen soziopolitischer Situation verdeutlicht. Sie beziehen sich auf Extrembedingungen in stadtfernen Gebieten und im Kontakt mit den indigenen Tr{\"a}gern und Helfern w{\"a}hrend der einzelnen Exkursionen. Die Darstellungen der allt{\"a}glichen Gegebenheiten sind zugleich eine interessante Quelle f{\"u}r Verhaltensmuster der verschiedenen Schichten der spanischkolonialen Gesellschaft wie der Forschungsreisenden, die mit den Schwierigkeiten umzugehen hatten, sich anzupassen verstanden oder ihre eigenen Verhaltensmuster entwickelt haben. Damit erm{\"o}glichen Humboldts Aufzeichnungen zugleich auch auf diesem Gebiet manchen Blick auf den seither erfolgten Kulturwandel.}, language = {de} } @article{Schwarz2013, author = {Schwarz, Ingo}, title = {Hanno Beck zum 90. Geburtstag}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70113}, pages = {84 -- 86}, year = {2013}, language = {de} } @article{OPUS4-6886, title = {{\"U}ber die Autoren}, volume = {XIV}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-71271}, pages = {68 -- 69}, year = {2013}, language = {de} } @article{Schnoepf2013, author = {Schn{\"o}pf, Markus}, title = {Evaluationskriterien f{\"u}r digitale Editionen und die reale Welt}, series = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, volume = {XIV}, journal = {HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies}, number = {27}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70091}, pages = {69 -- 76}, year = {2013}, abstract = {In den letzten Jahren sind immer mehr Editionen im Internet erschienen. Sie zeigen eine {\"a}hnlich große Vielfalt wie gedruckte Editionen. Somit ist es an der Zeit, den Begriff der digitalen Edition zu sch{\"a}rfen. Wie k{\"o}nnen digitale Editionen eingeordnet und evaluiert werden? Wie k{\"o}nnen neben editionswissenschaftlichen Kriterien weitere Bewertungssysteme dazu beitragen, qualitative Unterschiede zwischen den vorhandenen Editionen herauszuarbeiten? Das Institut f{\"u}r Dokumentologie und Editorik hat dazu einen Kriterienkatalog erstellt, der in diesem Beitrag einerseits vorgestellt werden soll, andererseits an bestehende Projekte angewendet werden soll. Ziel dieser {\"U}bung ist, den Blick auf digital vorliegende Quellen zu sch{\"a}rfen.}, language = {de} } @article{Moennich2013, author = {M{\"o}nnich, Katja}, title = {Eine Freundschaft, die Jahrzehnte {\"u}berdauerte!}, series = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, volume = {XIV}, journal = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-66716}, pages = {6 -- 11}, year = {2013}, abstract = {Der vorliegende Brief Alexander von Humboldts an seinen Jugendfreund Johann Karl Freiesleben (1774-1846) reiht sich ein in das Vorhaben, unpublizierte Briefe aus Humboldts Jugendzeit der {\"O}ffentlichkeit zug{\"a}nglich zu machen. Editorisch f{\"u}gt sich der Brief in die von Ilse Jahn und Fritz Gustav Lange herausgegebenen Jugendbriefe Alexander von Humboldts 1787-1799 ein. In diesem Band findet der Brief seinen Platz zwischen zwei Briefen Humboldts an Freiesleben, die er w{\"a}hrend seines Aufenthaltes in Dresden am 10.07.1797 sowie am 11. oder 18.07.1797 geschrieben hat.}, language = {de} } @article{Doherr2013, author = {Doherr, Detlev}, title = {Interconnectedness und digitale Texte}, series = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, volume = {XIV}, journal = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-66728}, pages = {13 -- 19}, year = {2013}, abstract = {Die multimedialen Informationsdienste im Internet werden immer umfangreicher und umfassender, wobei auch die nur in gedruckter Form vorliegenden Dokumente von den Bibliotheken digitalisiert und ins Netz gestellt werden. {\"U}ber Online-Dokumentenverwaltungen oder Suchmaschinen k{\"o}nnen diese Dokumente gefunden und dann in g{\"a}ngigen Formaten wie z.B. PDF bereitgestellt werden. Dieser Artikel beleuchtet die Funktionsweise der Humboldt Digital Library, die seit mehr als zehn Jahren Dokumente von Alexander von Humboldt in englischer {\"U}bersetzung im Web als HDL (Humboldt Digital Library) kostenfrei zur Verf{\"u}gung stellt. Anders als eine digitale Bibliothek werden dabei allerdings nicht nur digitalisierte Dokumente als Scan oder PDF bereitgestellt, sondern der Text als solcher und in vernetzter Form verf{\"u}gbar gemacht. Das System gleicht damit eher einem Informationssystem als einer digitalen Bibliothek, was sich auch in den verf{\"u}gbaren Funktionen zur Auffindung von Texten in unterschiedlichen Versionen und {\"U}bersetzungen, Vergleichen von Abs{\"a}tzen verschiedener Dokumente oder der Darstellung von Bilden in ihrem Kontext widerspiegelt. Die Entwicklung von dynamischen Hyperlinks auf der Basis der einzelnen Textabs{\"a}tze der Humboldt'schen Werke in Form von Media Assets erm{\"o}glicht eine Nutzung der Programmierschnittstelle von Google Maps zur geographischen wie auch textinhaltlichen Navigation. {\"U}ber den Service einer digitalen Bibliothek hinausgehend, bietet die HDL den Prototypen eines mehrdimensionalen Informationssystems, das mit dynamischen Strukturen arbeitet und umfangreiche thematische Auswertungen und Vergleiche erm{\"o}glicht.}, language = {de} } @article{ThiemerSachse2013, author = {Thiemer-Sachse, Ursula}, title = {Steinpatrizen aus dem alten Kolumbien zur Vorbereitung des Gusses von Goldobjekten in verlorener Form}, series = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, volume = {XIV}, journal = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-66733}, pages = {20 -- 26}, year = {2013}, abstract = {Im vorspanischen Zentralkolumbien, vor allem in der Muisca-Kultur, wurden Hochreliefs auf Steinpatrizen zur Abformung von Wachsmatrizen f{\"u}r den Guss in verlorener Form benutzt, die Alexander von Humboldt irrt{\"u}mlich f{\"u}r „Kalendersteine" der Muisca hielt. Der wissenschaftsgeschichtliche {\"U}berblick besch{\"a}ftigt sich mit den Ursachen dieses Irrtums und dessen {\"U}berwindung.}, language = {de} } @article{Schneider2013, author = {Schneider, Birgit}, title = {Berglinien im Vergleich}, series = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, volume = {XIV}, journal = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-66745}, pages = {27 -- 44}, year = {2013}, abstract = {Der Artikel analysiert aus bildwissenschaftlicher und historischer Perspektive die unver{\"o}ffentlichte Skizze zu einem Bergdiagramm aus dem handschriftlichen Nachlass Alexander von Humboldts. Das mehrfach beklebte Skizzenblatt stand im Zentrum klimageografischer Fragestellungen nach den Gr{\"u}nden f{\"u}r die weltweit unterschiedlich hohen Schneegrenzen in Gebirgen. Aufgrund des unfertigen, skizzenhaften Charakters des Diagramms lassen sich Fragen {\"u}ber den Forschungskontext des Diagramms, den epistemischen Stellenwert zeichnerischer Praktiken sowie {\"u}ber die heuristische Rolle der Berge und ihrer charakteristischen Profillinien in Humboldts Forschungen stellen. Gezeigt wird, wie das visuelle Denken und das Interesse Humboldts an neuen grafischen Methoden zu einer wichtigen Bedingung wurden, um die holistische Synopsis der Welt als {\"o}kologisches System erforschen und darstellen zu k{\"o}nnen.}, language = {de} } @article{Schwarz2013, author = {Schwarz, Ingo}, title = {Friedrich L. Brand}, series = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, volume = {XIV}, journal = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-66759}, pages = {45 -- 48}, year = {2013}, language = {de} } @article{Knobloch2013, author = {Knobloch, Eberhard}, title = {„Es w{\"a}re mir unm{\"o}glich nur ein halbes Jahr so zu leben wie er"}, series = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, volume = {XIV}, journal = {HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies}, number = {26}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-66766}, pages = {49 -- 68}, year = {2013}, language = {de} } @article{Knobloch2008, author = {Knobloch, Eberhard}, title = {Publikationen von Herbert Pieper}, volume = {IX}, number = {16}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42238}, pages = {5 -- 9}, year = {2008}, language = {de} } @article{OPUS4-4134, title = {{\"U}ber die Autoren}, volume = {XI}, number = {20}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42991}, year = {2010}, language = {de} } @article{Jobst2007, author = {Jobst, Anne}, title = {"Briefe wie gemahlt"}, volume = {VIII}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41654}, pages = {6 -- 9}, year = {2007}, abstract = {Am 19. Dezember 1831 wurde der verdienstvolle Mikrobiologe Christian Gottfried Ehrenberg zum korrespondierenden Mitglied des Institut de France gew{\"a}hlt. Alexander von Humboldt, der Ehrenberg als Wissenschaftler hoch sch{\"a}tzte, hat sich energisch f{\"u}r diese Wahl eingesetzt. Ein Zeugnis seines Engagements ist ein Brief an den Mediziner Antoine Baron Portal (1742-1832), den er um seine Stimme bei der bevorstehenden Wahl bat. Die Geschichte der Wahl Ehrenbergs in Verbindung mit diesem Brief und die Gr{\"u}nde f{\"u}r Humboldts Interesse daran sollen hier kurz skizziert werden.}, language = {de} } @article{HampeMartinez2007, author = {Hampe Mart{\´i}nez, Teodoro}, title = {Introducci{\´o}n al tema de enfoque "Humboldt y la Am{\´e}rica ilustrada"}, volume = {VIII}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41661}, pages = {10 -- 11}, year = {2007}, language = {es} } @article{HampeMartinez2007, author = {Hampe Mart{\´i}nez, Teodoro}, title = {Humboldt y el mar peruano}, volume = {VIII}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41678}, pages = {13 -- 21}, year = {2007}, abstract = {La presencia del cient{\´i}fico berlin{\´e}s Alexander von Humboldt en las actuales Rep{\´u}blicas del Ecuador y Per{\´u} (desde enero de 1802 hasta febrero de 1803) trajo consigo una serie de sustanciales aportes al conocimiento cient{\´i}fico de ambas naciones. Bien sabido es que Humboldt, considerado desde aquella {\´e}poca un verdadero Universalgelehrter o «sabio universal», fue capaz de resumir los saberes de disciplinas tan variadas como la etnolog{\´i}a, la arqueolog{\´i}a, la ling{\"u}{\´i}stica, la mineralog{\´i}a, la geolog{\´i}a, la bot{\´a}nica, la oceanograf{\´i}a y la biolog{\´i}a marina, entre otras. Con respecto al Oc{\´e}ano Pac{\´i}fico, sus aportaciones m{\´a}s importantes est{\´a}n vinculadas a la n{\´a}utica y la cosmograf{\´i}a, entre las cuales destacan su determinaci{\´o}n de la longitud del puerto del Callao y su teor{\´i}a sobre el origen de las aguas fr{\´i}as de la Corriente Peruana. Aqu{\´i} nos fijaremos especialmente en las incidencias personales y en los apuntes manuscritos que Humboldt realiz{\´o} durante su navegaci{\´o}n del Callao ?salida mar{\´i}tima de Lima? hasta Guayaquil, la cual tuvo lugar entre diciembre de 1802 y enero de 1803 a bordo de la corbeta real Castor, comandada por el teniente de fragata Jos{\´e} de Moraleda y Montero.}, language = {es} } @article{OrtizSotelo2007, author = {Ortiz Sotelo, Jorge}, title = {Aportes de Humboldt}, volume = {VIII}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41686}, pages = {23 -- 31}, year = {2007}, abstract = {La corta estad{\´i}a de Alexander von Humboldt en el Per{\´u} dej{\´o} su huella m{\´a}s notoria en el estudio que realizara del sistema de corrientes mar{\´i}timas que fluyen delante de la costa peruana, bautizada en su honor Corriente de Humboldt o la Corriente Peruana. Para ello llev{\´o} a cabo varias mediciones de la temperatura de mar durante su viaje de Trujillo a Lima, durante su permanencia en El Callao, y en el viaje que realiz{\´o} entre dicho puerto y Guayaquil a bordo de la corbeta de la Real Armada Castor. Por otro lado, con la colaboraci{\´o}n de algunos oficiales de la Real Armada estacionados en El Callao realiz{\´o} observaciones astron{\´o}micas que le permitieron determinar con mayor precisi{\´o}n la longitud del puerto de El Callao. En este trabajo se abordan estos aspectos de la presencia de Humboldt en el Per{\´u}.}, language = {es} } @article{PuigSamperRebok2007, author = {Puig-Samper, Miguel {\´A}ngel and Rebok, Sandra}, title = {Alejandro de Humboldt y Espa{\~n}a}, volume = {VIII}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41696}, pages = {33 -- 47}, year = {2007}, abstract = {Este estudio ofrece una visi{\´o}n muy general de la estancia de Alexander von Humboldt en Espa{\~n}a en el primer semestre de 1799 as{\´i} como de la preparaci{\´o}n de su viaje americano durante ese espacio de tiempo. Gracias a diversos documentos que han podido ser localizados en el transcurso de un proyecto de investigaci{\´o}n sobre este tema se han podido llenar unos vanos en la investigaci{\´o}n humboldtiana. Se presentan los motivos por los que el prusiano, junto a su compa{\~n}ero de viaje franc{\´e}s Aim{\´e} Bonpland, emprendi{\´o} el camino hac{\´i}a la Pen{\´i}nsula Ib{\´e}rica, su itinerario y las actividades cient{\´i}ficas llevadas a cabo por ellos. Adem{\´a}s, se analiza el significado que para {\´e}l tuvo su estancia en Espa{\~n}a, interpretado a partir de sus propios escritos, y se describe as{\´i} mismo su colaboraci{\´o}n con la comunidad cient{\´i}fica de Madrid. Especial atenci{\´o}n se ha puesto en detallar la preparaci{\´o}n administrativa en Madrid de su expedici{\´o}n a Am{\´e}rica, as{\´i} como los documentos creados y utilizados en este proceso. En el anexo se adjuntan dos documentos poco conocidos: la memoria entregada por Humboldt al rey Carlos IV y un pasaporte firmado por Mariano Luis de Urquijo.}, language = {es} } @article{OPUS4-4127, title = {{\"U}ber die Autoren}, volume = {X}, number = {19}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42902}, year = {2009}, language = {de} } @article{OPUS4-4086, title = {{\"U}ber die Autoren}, volume = {X}, number = {18}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42600}, year = {2009}, language = {de} } @article{OPUS4-4079, title = {Hinweis auf die elektronischen Ressourcen, bereitgestellt von der Alexander-von-Humboldt-Forschungsstelle der Berlin-Brandenburgischen Akademie der Wissenschaften}, volume = {IX}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42495}, year = {2008}, language = {de} } @article{BoernertRinglebWestphalZarubaetal.2020, author = {B{\"o}rnert-Ringleb, Moritz and Westphal, Andrea and Zaruba, Nicole and Gutmann, Franziska and Vock, Miriam}, title = {The relationship between attitudes toward inclusion, beliefs about teaching and learning, and subsequent automatic evaluations amongst student teachers}, series = {Frontiers in education}, volume = {5}, journal = {Frontiers in education}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2504-284X}, doi = {10.3389/feduc.2020.584464}, pages = {11}, year = {2020}, abstract = {Teachers' attitudes toward inclusion are frequently cited as being an important predictor of how successfully a given inclusive school system is implemented. At the same time, beliefs about the nature of teaching and learning are discussed as a possible predictor of attitudes toward inclusion. However, more recent research emphasizes the need of considering implicit processes, such as automatic evaluations, when describing attitudes and beliefs. Previous evidence on the association of attitudes toward inclusion and beliefs about teaching and learning is solely based on explicit reports. Therefore, this study aims to examine the relationship between attitudes toward inclusion, beliefs about teaching and learning, and the subsequent automatic evaluations of pre-service teachers (N = 197). The results revealed differences between pre-service teachers' explicit attitudes/beliefs and their subsequent automatic evaluations. Differences in the relationship between attitudes toward inclusion and beliefs about teaching and learning occur when teachers focus either on explicit measures or automatic evaluations. These differences might be due to different facets of the same attitude object being represented. Relying solely on either explicit measures or automatic evaluations at the exclusion of the other might lead to erroneous assumptions about the relation of attitudes toward inclusion and beliefs about teaching and learning.}, language = {en} } @article{ZollDiehlSiebert2019, author = {Zoll, Felix and Diehl, Katharina and Siebert, Rosemarie}, title = {Integrating sustainability goals in innovation processes}, series = {Sustainability}, volume = {11}, journal = {Sustainability}, number = {14}, publisher = {MDPI}, address = {Basel}, issn = {2071-1050}, doi = {10.3390/su11143761}, pages = {15}, year = {2019}, abstract = {The innovative dual-purpose chicken approach aims at contributing to the transition towards sustainable poultry production by avoiding the culling of male chickens. To successfully integrate sustainability aspects into innovation, goal congruency among actors and clearly communicating the added value within the actor network and to consumers is needed. The challenge of identifying common sustainability goals calls for decision support tools. The objectives of our research were to investigate whether the tool could assist in improving communication and marketing with respect to sustainability and optimizing the value chain organization. Three actor groups participated in the tool application, in which quantitative and qualitative data were collected. The results showed that there were manifold sustainability goals within the innovation network, but only some goals overlapped, and the perception of their implementation also diverged. While easily marketable goals such as 'animal welfare' were perceived as being largely implemented, economic goals were prioritized less often, and the implementation was perceived as being rather low. By visualizing congruencies and differences in the goals, the tool helped identify fields of action, such as improved information flows and prompted thinking processes. We conclude that the tool is useful for managing complex decision processes with several actors involved.}, language = {en} } @article{BrinkmannKoellnerMerketal.2023, author = {Brinkmann, Pia and K{\"o}llner, Nicole and Merk, Sven and Beitz, Toralf and Altenberger, Uwe and L{\"o}hmannsr{\"o}ben, Hans-Gerd}, title = {Comparison of handheld and echelle spectrometer to assess copper in ores by means of laser-induced breakdown spectroscopy (LIBS)}, series = {Minerals}, volume = {13}, journal = {Minerals}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2075-163X}, doi = {10.3390/min13010113}, pages = {19}, year = {2023}, abstract = {Its properties make copper one of the world's most important functional metals. Numerous megatrends are increasing the demand for copper. This requires the prospection and exploration of new deposits, as well as the monitoring of copper quality in the various production steps. A promising technique to perform these tasks is Laser Induced Breakdown Spectroscopy (LIBS). Its unique feature, among others, is the ability to measure on site without sample collection and preparation. In this work, copper-bearing minerals from two different deposits are studied. The first set of field samples come from a volcanogenic massive sulfide (VMS) deposit, the second part from a stratiform sedimentary copper (SSC) deposit. Different approaches are used to analyze the data. First, univariate regression (UVR) is used. However, due to the strong influence of matrix effects, this is not suitable for the quantitative analysis of copper grades. Second, the multivariate method of partial least squares regression (PLSR) is used, which is more suitable for quantification. In addition, the effects of the surrounding matrices on the LIBS data are characterized by principal component analysis (PCA), alternative regression methods to PLSR are tested and the PLSR calibration is validated using field samples.}, language = {en} } @article{VidalGarciaBandaraKeogh2018, author = {Vidal-Garcia, Marta and Bandara, Lashi and Keogh, J. Scott}, title = {ShapeRotator}, series = {Ecology and evolution}, volume = {8}, journal = {Ecology and evolution}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {2045-7758}, doi = {10.1002/ece3.4018}, pages = {4669 -- 4675}, year = {2018}, abstract = {The quantification of complex morphological patterns typically involves comprehensive shape and size analyses, usually obtained by gathering morphological data from all the structures that capture the phenotypic diversity of an organism or object. Articulated structures are a critical component of overall phenotypic diversity, but data gathered from these structures are difficult to incorporate into modern analyses because of the complexities associated with jointly quantifying 3D shape in multiple structures. While there are existing methods for analyzing shape variation in articulated structures in two-dimensional (2D) space, these methods do not work in 3D, a rapidly growing area of capability and research. Here, we describe a simple geometric rigid rotation approach that removes the effect of random translation and rotation, enabling the morphological analysis of 3D articulated structures. Our method is based on Cartesian coordinates in 3D space, so it can be applied to any morphometric problem that also uses 3D coordinates (e.g., spherical harmonics). We demonstrate the method by applying it to a landmark-based dataset for analyzing shape variation using geometric morphometrics. We have developed an R tool (ShapeRotator) so that the method can be easily implemented in the commonly used R package geomorph and MorphoJ software. This method will be a valuable tool for 3D morphological analyses in articulated structures by allowing an exhaustive examination of shape and size diversity.}, language = {en} } @article{ScheibelTrappLimbergeretal.2020, author = {Scheibel, Willy and Trapp, Matthias and Limberger, Daniel and D{\"o}llner, J{\"u}rgen Roland Friedrich}, title = {A taxonomy of treemap visualization techniques}, series = {Science and Technology Publications}, journal = {Science and Technology Publications}, publisher = {Springer}, address = {Berlin}, pages = {8}, year = {2020}, abstract = {A treemap is a visualization that has been specifically designed to facilitate the exploration of tree-structured data and, more general, hierarchically structured data. The family of visualization techniques that use a visual metaphor for parent-child relationships based "on the property of containment" (Johnson, 1993) is commonly referred to as treemaps. However, as the number of variations of treemaps grows, it becomes increasingly important to distinguish clearly between techniques and their specific characteristics. This paper proposes to discern between Space-filling Treemap TS, Containment Treemap TC, Implicit Edge Representation Tree TIE, and Mapped Tree TMT for classification of hierarchy visualization techniques and highlights their respective properties. This taxonomy is created as a hyponymy, i.e., its classes have an is-a relationship to one another: TS TC TIE TMT. With this proposal, we intend to stimulate a discussion on a more unambiguous classification of treemaps and, furthermore, broaden what is understood by the concept of treemap itself.}, language = {en} } @article{HudsonHagedoornBubeck2020, author = {Hudson, Paul and Hagedoorn, Liselotte and Bubeck, Philip}, title = {Potential linkages between social capital, flood risk perceptions, and self-efficacy}, series = {International journal of disaster risk science}, volume = {11}, journal = {International journal of disaster risk science}, number = {3}, publisher = {Springer}, address = {Berlin}, issn = {2095-0055}, doi = {10.1007/s13753-020-00259-w}, pages = {251 -- 262}, year = {2020}, abstract = {A growing focus is being placed on both individuals and communities to adapt to flooding as part of the Sendai Framework for Disaster Risk Reduction 2015-2030. Adaptation to flooding requires sufficient social capital (linkages between members of society), risk perceptions (understanding of risk), and self-efficacy (self-perceived ability to limit disaster impacts) to be effective. However, there is limited understanding of how social capital, risk perceptions, and self-efficacy interact. We seek to explore how social capital interacts with variables known to increase the likelihood of successful adaptation. To study these linkages we analyze survey data of 1010 respondents across two communities in Thua Tien-Hue Province in central Vietnam, using ordered probit models. We find positive correlations between social capital, risk perceptions, and self-efficacy overall. This is a partly contrary finding to what was found in previous studies linking these concepts in Europe, which may be a result from the difference in risk context. The absence of an overall negative exchange between these factors has positive implications for proactive flood risk adaptation.}, language = {en} } @article{BanerjeeLipowskySanter2020, author = {Banerjee, Pallavi and Lipowsky, Reinhard and Santer, Mark}, title = {Coarse-grained molecular model for the Glycosylphosphatidylinositol anchor with and without protein}, series = {Journal of Chemical Theory and Computation}, volume = {16}, journal = {Journal of Chemical Theory and Computation}, number = {6}, publisher = {ACS Publications}, address = {Washington DC}, issn = {1549-9626}, doi = {10.1021/acs.jctc.0c00056}, pages = {15}, year = {2020}, abstract = {Glycosylphosphatidylinositol (GPI) anchors are a unique class of complex glycolipids that anchor a great variety of proteins to the extracellular leaflet of plasma membranes of eukaryotic cells. These anchors can exist either with or without an attached protein called GPI-anchored protein (GPI-AP) both in vitro and in vivo. Although GPIs are known to participate in a broad range of cellular functions, it is to a large extent unknown how these are related to GPI structure and composition. Their conformational flexibility and microheterogeneity make it difficult to study them experimentally. Simplified atomistic models are amenable to all-atom computer simulations in small lipid bilayer patches but not suitable for studying their partitioning and trafficking in complex and heterogeneous membranes. Here, we present a coarse-grained model of the GPI anchor constructed with a modified version of the MARTINI force field that is suited for modeling carbohydrates, proteins, and lipids in an aqueous environment using MARTINI's polarizable water. The nonbonded interactions for sugars were reparametrized by calculating their partitioning free energies between polar and apolar phases. In addition, sugar-sugar interactions were optimized by adjusting the second virial coefficients of osmotic pressures for solutions of glucose, sucrose, and trehalose to match with experimental data. With respect to the conformational dynamics of GPI-anchored green fluorescent protein, the accessible time scales are now at least an order of magnitude larger than for the all-atom system. This is particularly important for fine-tuning the mutual interactions of lipids, carbohydrates, and amino acids when comparing to experimental results. We discuss the prospective use of the coarse-grained GPI model for studying protein-sorting and trafficking in membrane models.}, language = {en} } @article{HartungBorghardt2020, author = {Hartung, Niklas and Borghardt, Jens Markus}, title = {A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs}, series = {PLoS Computational Biology : a new community journal}, volume = {16}, journal = {PLoS Computational Biology : a new community journal}, number = {12}, publisher = {PLoS}, address = {San Fransisco}, issn = {1553-734X}, doi = {10.1371/journal.pcbi.1008466}, pages = {24}, year = {2020}, abstract = {Author summary
The use of orally inhaled drugs for treating lung diseases is appealing since they have the potential for lung selectivity, i.e. high exposure at the site of action -the lung- without excessive side effects. However, the degree of lung selectivity depends on a large number of factors, including physiochemical properties of drug molecules, patient disease state, and inhalation devices. To predict the impact of these factors on drug exposure and thereby to understand the characteristics of an optimal drug for inhalation, we develop a predictive mathematical framework (a "pharmacokinetic model"). In contrast to previous approaches, our model allows combining knowledge from different sources appropriately and its predictions were able to adequately predict different sets of clinical data. Finally, we compare the impact of different factors and find that the most important factors are the size of the inhaled particles, the affinity of the drug to the lung tissue, as well as the rate of drug dissolution in the lung. In contrast to the common belief, the solubility of a drug in the lining fluids is not found to be relevant. These findings are important to understand how inhaled drugs should be designed to achieve best treatment results in patients.
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Even though each single process has been systematically investigated, a quantitative understanding on the interaction of processes remains limited and therefore identifying optimal drug and formulation characteristics for orally inhaled drugs is still challenging. To investigate this complex interplay, the pulmonary processes can be integrated into mathematical models. However, existing modeling attempts considerably simplify these processes or are not systematically evaluated against (clinical) data. In this work, we developed a mathematical framework based on physiologically-structured population equations to integrate all relevant pulmonary processes mechanistically. A tailored numerical resolution strategy was chosen and the mechanistic model was evaluated systematically against data from different clinical studies. Without adapting the mechanistic model or estimating kinetic parameters based on individual study data, the developed model was able to predict simultaneously (i) lung retention profiles of inhaled insoluble particles, (ii) particle size-dependent pharmacokinetics of inhaled monodisperse particles, (iii) pharmacokinetic differences between inhaled fluticasone propionate and budesonide, as well as (iv) pharmacokinetic differences between healthy volunteers and asthmatic patients. Finally, to identify the most impactful optimization criteria for orally inhaled drugs, the developed mechanistic model was applied to investigate the impact of input parameters on both the pulmonary and systemic exposure. Interestingly, the solubility of the inhaled drug did not have any relevant impact on the local and systemic pharmacokinetics. Instead, the pulmonary dissolution rate, the particle size, the tissue affinity, and the systemic clearance were the most impactful potential optimization parameters. In the future, the developed prediction framework should be considered a powerful tool for identifying optimal drug and formulation characteristics.}, language = {en} } @article{CanitzKirschbaumTiedemann2020, author = {Canitz, Julia and Kirschbaum, Frank and Tiedemann, Ralph}, title = {Transcriptome-wide single nucleotide polymorphisms related to electric organ discharge differentiation among African weakly electric fish species}, series = {PLoS one}, volume = {15}, journal = {PLoS one}, number = {10}, publisher = {PLoS}, address = {San Francisco, California, US}, issn = {1932-6203}, doi = {10.1371/journal.pone.0240812}, pages = {21}, year = {2020}, abstract = {African weakly electric fish of the mormyrid genus Campylomormyrus generate pulse-type electric organ discharges (EODs) for orientation and communication. Their pulse durations are species-specific and elongated EODs are a derived trait. So far, differential gene expression among tissue-specific transcriptomes across species with different pulses and point mutations in single ion channel genes indicate a relation of pulse duration and electrocyte geometry/excitability. However, a comprehensive assessment of expressed Single Nucleotide Polymorphisms (SNPs) throughout the entire transcriptome of African weakly electric fish, with the potential to identify further genes influencing EOD duration, is still lacking. This is of particular value, as discharge duration is likely based on multiple cellular mechanisms and various genes. Here we provide the first transcriptome-wide SNP analysis of African weakly electric fish species (genus Campylomormyrus) differing by EOD duration to identify candidate genes and cellular mechanisms potentially involved in the determination of an elongated discharge of C. tshokwe. Non-synonymous substitutions specific to C. tshokwe were found in 27 candidate genes with inferred positive selection among Campylomormyrus species. These candidate genes had mainly functions linked to transcriptional regulation, cell proliferation and cell differentiation. Further, by comparing gene annotations between C. compressirostris (ancestral short EOD) and C. tshokwe (derived elongated EOD), we identified 27 GO terms and 2 KEGG pathway categories for which C. tshokwe significantly more frequently exhibited a species-specific expressed substitution than C. compressirostris. The results indicate that transcriptional regulation as well cell proliferation and differentiation take part in the determination of elongated pulse durations in C. tshokwe. Those cellular processes are pivotal for tissue morphogenesis and might determine the shape of electric organs supporting the observed correlation between electrocyte geometry/tissue structure and discharge duration. The inferred expressed SNPs and their functional implications are a valuable resource for future investigations on EOD durations.}, language = {en} } @article{WiebkingLinWippert2022, author = {Wiebking, Christine and Lin, Chiao-I and Wippert, Pia-Maria}, title = {Training intervention effects on cognitive performance and neuronal plasticity — A pilot study}, series = {Frontiers in Neurology, section Neurorehabilitation}, volume = {13}, journal = {Frontiers in Neurology, section Neurorehabilitation}, publisher = {Frontiers}, address = {Lausanne, Schweiz}, issn = {1664-2295}, doi = {10.3389/fneur.2022.773813}, pages = {11}, year = {2022}, abstract = {Studies suggest that people suffering from chronic pain may have altered brain plasticity, along with altered functional connectivity between pain-processing brain regions. These may be related to decreased mood and cognitive performance. There is some debate as to whether physical activity combined with behavioral therapy (e.g. cognitive distraction, body scan) may counteract these changes. However, underlying neuronal mechanisms are unclear. The aim of the current pilot study with a 3-armed randomized controlled trial design was to examine the effects of sensorimotor training for nonspecific chronic low back pain on (1) cognitive performance; (2) fMRI activity co-fluctuations (functional connectivity) between pain-related brain regions; and (3) the relationship between functional connectivity and subjective variables (pain and depression). Six hundred and sixty two volunteers with non-specific chronic low back pain were randomly allocated to a unimodal (sensorimotor training), multidisciplinary (sensorimotor training and behavioral therapy) intervention, or to a control group within a multicenter study. A subsample of patients (n = 21) from one study center participated in the pilot study presented here. Measurements were at baseline, during (3 weeks, M2) and after intervention (12 weeks, M4 and 24 weeks, M5). Cognitive performance was measured by the Trail Making Test and functional connectivity by MRI. Pain perception and depression were assessed by the Von Korff questionnaire and the Hospital and Anxiety. Group differences were calculated by univariate and repeated ANOVA measures and Bayesian statistics; correlations by Pearson's r. Change and correlation of functional connection were analyzed within a pooled intervention group (uni-, multidisciplinary group). Results revealed that participants with increased pain intensity at baseline showed higher functional connectivity between pain-related brain areas used as ROIs in this study. Though small sample sizes limit generalization, cognitive performance increased in the multimodal group. Increased functional connectivity was observed in participants with increased pain ratings. Pain ratings and connectivity in pain-related brain regions decreased after the intervention. The results provide preliminary indication that intervention effects can potentially be achieved on the cognitive and neuronal level. The intervention may be suitable for therapy and prevention of non-specific chronic low back pain.}, language = {en} } @article{BlockBonaventuraGrahnetal.2022, author = {Block, Andrea and Bonaventura, Klaus and Grahn, Patricia and Bestgen, Felix and Wippert, Pia-Maria}, title = {Stress management in pre-and postoperative care amongst practitioners and patients in cardiac catheterization laboratory: a study protocol}, series = {Frontiers in Cardiovascular Medicine}, volume = {9}, journal = {Frontiers in Cardiovascular Medicine}, publisher = {Frontiers}, address = {Lausanne, Schweiz}, issn = {2297-055X}, doi = {10.3389/fcvm.2022.830256}, pages = {1 -- 10}, year = {2022}, abstract = {Background: As the number of cardiac diseases continuously increases within the last years in modern society, so does cardiac treatment, especially cardiac catheterization. The procedure of a cardiac catheterization is challenging for both patients and practitioners. Several potential stressors of psychological or physical nature can occur during the procedure. The objective of the study is to develop and implement a stress management intervention for both practitioners and patients that aims to reduce the psychological and physical strain of a cardiac catheterization. Methods: The clinical study (DRKS00026624) includes two randomized controlled intervention trials with parallel groups, for patients with elective cardiac catheterization and practitioners at the catheterization lab, in two clinic sites of the Ernst-von-Bergmann clinic network in Brandenburg, Germany. Both groups received different interventions for stress management. The intervention for patients comprises a psychoeducational video with different stress management technics and additional a standardized medical information about the cardiac catheterization examination. The control condition includes the in hospitals practiced medical patient education before the examination (usual care). Primary and secondary outcomes are measured by physiological parameters and validated questionnaires, the day before (M1) and after (M2) the cardiac catheterization and at a postal follow-up 6 months later (M3). It is expected that people with standardized information and psychoeducation show reduced complications during cardiac catheterization procedures, better pre- and post-operative wellbeing, regeneration, mood and lower stress levels over time. The intervention for practitioners includes a Mindfulness-based stress reduction program (MBSR) over 8 weeks supervised by an experienced MBSR practitioner directly at the clinic site and an operative guideline. It is expected that practitioners with intervention show improved perceived and chronic stress, occupational health, physical and mental function, higher effort-reward balance, regeneration and quality of life. Primary and secondary outcomes are measured by physiological parameters (heart rate variability, saliva cortisol) and validated questionnaires and will be assessed before (M1) and after (M2) the MBSR intervention and at a postal follow-up 6 months later (M3). Physiological biomarkers in practitioners will be assessed before (M1) and after intervention (M2) on two work days and a two days off. Intervention effects in both groups (practitioners and patients) will be evaluated separately using multivariate variance analysis. Discussion: This study evaluates the effectiveness of two stress management intervention programs for patients and practitioners within cardiac catheter laboratory. Study will disclose strains during a cardiac catheterization affecting both patients and practitioners. For practitioners it may contribute to improved working conditions and occupational safety, preservation of earning capacity, avoidance of participation restrictions and loss of performance. In both groups less anxiety, stress and complications before and during the procedures can be expected. The study may add knowledge how to eliminate stressful exposures and to contribute to more (psychological) security, less output losses and exhaustion during work. The evolved stress management guidelines, training manuals and the standardized patient education should be transferred into clinical routines}, language = {en} } @article{EllermannMcDowellSchirrenetal.2022, author = {Ellermann, Christin and McDowell, Michelle and Schirren, Clara O. and Lindemann, Ann-Kathrin and Koch, Severine and Lohmann, Mark and Jenny, Mirjam Annina}, title = {Identifying content to improve risk assessment communications within the Risk Profile: Literature reviews and focus groups with expert and non-expert stakeholders}, series = {PLoS ONE}, volume = {17}, journal = {PLoS ONE}, edition = {4}, publisher = {Public Library of Science (PLOS)}, address = {San Francisco, California, USA}, issn = {1553-7358}, doi = {10.1371/journal.pone.0266800}, pages = {23}, year = {2022}, abstract = {Objective To improve consumer decision making, the results of risk assessments on food, feed, consumer products or chemicals need to be communicated not only to experts but also to non-expert audiences. The present study draws on evidence from literature reviews and focus groups with diverse stakeholders to identify content to integrate into an existing risk assessment communication (Risk Profile). Methods A combination of rapid literature reviews and focus groups with experts (risk assessors (n = 15), risk managers (n = 8)), and non-experts (general public (n = 18)) were used to identify content and strategies for including information about risk assessment results in the "Risk Profile" from the German Federal Institute for Risk Assessment. Feedback from initial focus groups was used to develop communication prototypes that informed subsequent feedback rounds in an iterative process. A final prototype was validated in usability tests with experts. Results Focus group feedback and suggestions from risk assessors were largely in line with findings from the literature. Risk managers and lay persons offered similar suggestions on how to improve the existing communication of risk assessment results (e.g., including more explanatory detail, reporting probabilities for individual health impairments, and specifying risks for subgroups in additional sections). Risk managers found information about quality of evidence important to communicate, whereas people from the general public found this information less relevant. Participants from lower educational backgrounds had difficulties understanding the purpose of risk assessments. User tests found that the final prototype was appropriate and feasible to implement by risk assessors. Conclusion An iterative and evidence-based process was used to develop content to improve the communication of risk assessments to the general public while being feasible to use by risk assessors. Remaining challenges include how to communicate dose-response relationships and standardise quality of evidence ratings across disciplines.}, language = {en} } @article{OseiBlockWippert2022, author = {Osei, Francis and Block, Andrea and Wippert, Pia-Maria}, title = {Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review}, series = {Frontiers in Endocrinology}, volume = {13}, journal = {Frontiers in Endocrinology}, publisher = {Frontiers}, address = {Lausanne, Schweiz}, issn = {1664-2392}, doi = {10.3389/fendo.2022.946740}, pages = {16}, year = {2022}, abstract = {Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case-control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case-control studies. The included studies had a completeness of reporting score of COR \% = 87.0 ± 6.4\%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50\% (urinary cortisol), 40\% (serum cortisol), 60\% (salivary cortisol), and 100\% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60\% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100\% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS.}, language = {en} } @article{KolyvushkoLatzkeDahmanietal.2020, author = {Kolyvushko, Oleksandr and Latzke, Juliane and Dahmani, Ismail and Osterrieder, Nikolaus and Chiantia, Salvatore and Azab, Walid}, title = {Differentially-charged liposomes interact with alphaherpesviruses and interfere with virus entry}, series = {Pathogens}, volume = {9}, journal = {Pathogens}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2076-0817}, doi = {10.3390/pathogens9050359}, pages = {9}, year = {2020}, abstract = {Exposure of phosphatidylserine (PS) in the outer leaflet of the plasma membrane is induced by infection with several members of the Alphaherpesvirinae subfamily. There is evidence that PS is used by the equine herpesvirus type 1 (EHV-1) during entry, but the exact role of PS and other phospholipids in the entry process remains unknown. Here, we investigated the interaction of differently charged phospholipids with virus particles and determined their influence on infection. Our data show that liposomes containing negatively charged PS or positively charged DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium) inhibited EHV-1 infection, while neutral phosphatidylcholine (PC) had no effect. Inhibition of infection with PS was transient, decreased with time, and was dose dependent. Our findings indicate that both cationic and anionic phospholipids can interact with the virus and reduce infectivity, while, presumably, acting through different mechanisms. Charged phospholipids were found to have antiviral effects and may be used to inhibit EHV-1 infection.}, language = {en} } @article{SeržantMoroz2022, author = {Seržant, Ilja A. and Moroz, George A.}, title = {Universal attractors in language evolution provide evidence for the kinds of efficiency pressures involved}, series = {Humanities \& Social Sciences Communications}, volume = {9}, journal = {Humanities \& Social Sciences Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-9992}, doi = {10.1057/s41599-022-01072-0}, pages = {9}, year = {2022}, abstract = {Efficiency is central to understanding the communicative and cognitive underpinnings of language. However, efficiency management is a complex mechanism in which different efficiency effects-such as articulatory, processing and planning ease, mental accessibility, and informativity, online and offline efficiency effects-conspire to yield the coding of linguistic signs. While we do not yet exactly understand the interactional mechanism of these different effects, we argue that universal attractors are an important component of any dynamic theory of efficiency that would be aimed at predicting efficiency effects across languages. Attractors are defined as universal states around which language evolution revolves. Methodologically, we approach efficiency from a cross-linguistic perspective on the basis of a world-wide sample of 383 languages from 53 families, balancing all six macro-areas (Eurasia, North and South America, Australia, Africa, and Oceania). We explore the grammatical domain of verbal person-number subject indexes. We claim that there is an attractor state in this domain to which languages tend to develop and tend not to leave if they happen to comply with the attractor in their earlier stages of evolution. The attractor is characterized by different lengths for each person and number combination, structured along Zipf's predictions. Moreover, the attractor strongly prefers non-compositional, cumulative coding of person and number. On the basis of these and other properties of the attractor, we conclude that there are two domains in which efficiency pressures are most powerful: strive towards less processing and articulatory effort. The latter, however, is overridden by constant information flow. Strive towards lower lexicon complexity and memory costs are weaker efficiency pressures for this grammatical category due to its order of frequency.}, language = {en} } @article{FliesserDeWittHubertsWippert2017, author = {Fliesser, Michael and De Witt Huberts, Jessie and Wippert, Pia-Maria}, title = {The choice that matters: the relative influence of socioeconomic status indicators on chronic back pain- a longitudinal study}, series = {BMC health services research}, volume = {17}, journal = {BMC health services research}, publisher = {BioMed Central}, address = {London}, issn = {1472-6963}, doi = {10.1186/s12913-017-2735-9}, pages = {8}, year = {2017}, abstract = {Background: In health research, indicators of socioeconomic status (SES) are often used interchangeably and often lack theoretical foundation. This makes it difficult to compare results from different studies and to explore the relationship between SES and health outcomes. To aid researchers in choosing appropriate indicators of SES, this article proposes and tests a theory-based selection of SES indicators using chronic back pain as a health outcome. Results: Chronic back pain intensity was best predicted by the multidimensional index (beta = 0.31, p < 0.05), followed by job position (beta = 0.29, p < 0.05) and education (beta = -0.29, p < 0.05); whereas, income exerted no significant influence. Back pain disability was predicted strongest by education (beta = -0.30, p < 0.05) and job position (beta = 0. 29, p < 0.05). Here, multidimensional index and income had no significant influence. Conclusions: The choice of SES indicators influences predictive power on both back pain dimensions, suggesting SES predictors cannot be used interchangeably. Therefore, researchers should carefully consider prior to each study which SES indicator to use. The introduced framework can be valuable in supporting this decision because it allows for a stable prediction of SES indicator influence and their hierarchy on a specific health outcomes.}, language = {en} } @article{StarzonekRoscherBlitheretal.2019, author = {Starzonek, Janine and Roscher, Katja and Blither, Matthias and Blaue, Dominique and Schedlbauer, Carola and Hire, Manuela and Raila, Jens and Vervuert, Ingrid}, title = {Effects of a blend of green tea and curcuma extract supplementation on lipopolysaccharide-induced inflammation in horses and ponies}, series = {PeerJ}, volume = {7}, journal = {PeerJ}, publisher = {PeerJ Inc.}, address = {London}, issn = {2167-8359}, doi = {10.7717/peerj.8053}, pages = {17}, year = {2019}, abstract = {Background. In horses and ponies numerous medical conditions are known to be linked with inflammation in different tissues, especially in the liver. Besides affecting other metabolic pathways such as the expression of certain interleukins (IL), inflammation is associated with stress of the endoplasmic reticulum (ER). In particular, ER stress leads to adaptive stress response and can be measured by several markers of inflammatory and stress signalling pathways, like nuclear factor kappa B (NF-kB). Objectives. To investigate lipopolysaccharide (LPS)-induced inflammatory reactions and their modulation in horses and ponies by feeding a polyphenol-rich supplement consisting of green tea and curcuma. Methods. In a cross-over study, 11 animals were allocated to either a placebo or a supplement group and supplemented with 10 g of a blend of green tea and curcuma extract (GCE) or a placebo (calcium carbonate) once daily. After 21 days of supplementation, all animals underwent a LPS challenge to induce moderate systemic inflammation. Blood samples and liver biopsies were taken at standardized time points: 24 hours before and 12 hours after LPS challenge. Inflammatory blood parameters such as serum amyloid A (SAA), haptoglobin and retinol binding protein 4 (RBP4) were measured in serum. Hepatic mRNA levels of selected markers of inflammation such as haptoglobin, tumor necrosis factor alpha (TNF-alpha), IL-1 beta, IL-6, cluster of differentiation 68 (CD68), fibroblast growth factor 21 (FGF-21), NF-kappa B, activating transcription factor 4 (ATF4) were quantified by RT-qPCR. In addition, liver biopsies were examined histologically for inflammatory alterations. Results. Blood markers of acute inflammatory response increased after LPS challenge. In the liver, the proinflammatory cytokine IL-1 beta showed significantly lower mRNA levels after LPS challenge in the supplemented group (P = 0.04) compared to the placebo group. Levels of the hepatic CD68 mRNA increased significantly in the placebo group (P = 0.04). There were no significant differences between supplemented and placebo groups concerning other markers of inflammation and markers of ER stress within the liver. The number of hepatic macrophages were not different after LPS challenge in both feeding groups. Conclusion. LPS was able to induce inflammation but seemed less suitable to induce ER stress in the horses and ponies. The polyphenol-rich supplement showed some potential to reduce inflammatory responses. Nevertheless, the supplementation did not exert an overall anti-inflammatory effect in horses and ponies.}, language = {en} } @article{TutuSteinbergerSobolevetal.2018, author = {Tutu, Anthony Osei and Steinberger, Bernhard and Sobolev, Stephan Vladimir and Rogozhina, Irina and Popov, Anton A.}, title = {Effects of upper mantle heterogeneities on the lithospheric stress field and dynamic topography}, series = {Solid earth}, volume = {9}, journal = {Solid earth}, number = {3}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1869-9510}, doi = {10.5194/se-9-649-2018}, pages = {649 -- 668}, year = {2018}, abstract = {The orientation and tectonic regime of the observed crustal/lithospheric stress field contribute to our knowledge of different deformation processes occurring within the Earth's crust and lithosphere. In this study, we analyze the influence of the thermal and density structure of the upper mantle on the lithospheric stress field and topography. We use a 3-D lithosphere-asthenosphere numerical model with power-law rheology, coupled to a spectral mantle flow code at 300 km depth. Our results are validated against the World Stress Map 2016 (WSM2016) and the observation-based residual topography. We derive the upper mantle thermal structure from either a heat flow model combined with a seafloor age model (TM1) or a global S-wave velocity model (TM2). We show that lateral density heterogeneities in the upper 300 km have a limited influence on the modeled horizontal stress field as opposed to the resulting dynamic topography that appears more sensitive to such heterogeneities. The modeled stress field directions, using only the mantle heterogeneities below 300 km, are not perturbed much when the effects of lithosphere and crust above 300 km are added. In contrast, modeled stress magnitudes and dynamic topography are to a greater extent controlled by the upper mantle density structure. After correction for the chemical depletion of continents, the TM2 model leads to a much better fit with the observed residual topography giving a good correlation of 0.51 in continents, but this correction leads to no significant improvement of the fit between the WSM2016 and the resulting lithosphere stresses. In continental regions with abundant heat flow data, TM1 results in relatively small angular misfits. For example, in western Europe the misfit between the modeled and observation-based stress is 18.3°. Our findings emphasize that the relative contributions coming from shallow and deep mantle dynamic forces are quite different for the lithospheric stress field and dynamic topography.}, language = {en} } @article{TchewonpiSaguLandgraeberHenkeletal.2021, author = {Tchewonpi Sagu, Sorel and Landgr{\"a}ber, Eva and Henkel, Ina M. and Huschek, Gerd and Homann, Thomas and Bußler, Sara and Schl{\"u}ter, Oliver K. and Rawel, Harshadrai Manilal}, title = {Effect of cereal α-amylase/trypsin inhibitors on developmental characteristics and abundance of digestive enzymes of mealworm larvae (Tenebrio molitor L.)}, series = {Insects}, volume = {12}, journal = {Insects}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2075-4450}, doi = {10.3390/insects12050454}, pages = {16}, year = {2021}, abstract = {The objective of this work was to investigate the potential effect of cereal α-amylase/trypsin inhibitors (ATIs) on growth parameters and selective digestive enzymes of Tenebrio molitor L. larvae. The approach consisted of feeding the larvae with wheat, sorghum and rice meals containing different levels and composition of α-amylase/trypsin inhibitors. The developmental and biochemical characteristics of the larvae were assessed over feeding periods of 5 h, 5 days and 10 days, and the relative abundance of α-amylase and selected proteases in larvae were determined using liquid chromatography tandem mass spectrometry. Overall, weight gains ranged from 21\% to 42\% after five days of feeding. The larval death rate significantly increased in all groups after 10 days of feeding (p < 0.05), whereas the pupation rate was about 25\% among larvae fed with rice (Oryza sativa L.) and Siyazan/Esperya wheat meals, and only 8\% and 14\% among those fed with Damougari and S35 sorghum meals. As determined using the Lowry method, the protein contents of the sodium phosphate extracts ranged from 7.80 ± 0.09 to 9.42 ± 0.19 mg/mL and those of the ammonium bicarbonate/urea reached 19.78 ± 0.16 to 37.47 ± 1.38 mg/mL. The total protein contents of the larvae according to the Kjeldahl method ranged from 44.0 and 49.9 g/100 g. The relative abundance of α-amylase, CLIP domain-containing serine protease, modular serine protease zymogen and C1 family cathepsin significantly decreased in the larvae, whereas dipeptidylpeptidase I and chymotrypsin increased within the first hours after feeding (p < 0.05). Trypsin content was found to be constant independently of time or feed material. Finally, based on the results we obtained, it was difficult to substantively draw conclusions on the likely effects of meal ATI composition on larval developmental characteristics, but their effects on the digestive enzyme expression remain relevant.}, language = {en} } @article{AloniPerovicWeitmanetal.2019, author = {Aloni, Sapir Shekef and Perovic, Milena and Weitman, Michal and Cohen, Reut and Oschatz, Martin and Mastai, Yitzhak}, title = {Amino acid-based ionic liquids as precursors for the synthesis of chiral nanoporous carbons}, series = {Nanoscale Advances}, volume = {1}, journal = {Nanoscale Advances}, number = {12}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2516-0230}, doi = {10.1039/c9na00520j}, pages = {4981 -- 4988}, year = {2019}, abstract = {The synthesis of chiral nanoporous carbons based on chiral ionic liquids (CILs) of amino acids as precursors is described. Such unique precursors for the carbonization of CILs yield chiral carbonaceous materials with high surface area (approximate to 620 m(2) g(-1)). The enantioselectivities of the porous carbons are examined by advanced techniques such as selective adsorption of enantiomers using cyclic voltammetry, isothermal titration calorimetry, and mass spectrometry. These techniques demonstrate the chiral nature and high enantioselectivity of the chiral carbon materials. Overall, we believe that the novel approach presented here can contribute significantly to the development of new chiral carbon materials that will find important applications in chiral chemistry, such as in chiral catalysis and separation and in chiral sensors. From a scientific point of view, the approach and results reported here can significantly deepen our understanding of chirality at the nanoscale and of the structure and nature of chiral nonporous materials and surfaces.}, language = {en} } @article{MendelHercherZupoketal.2020, author = {Mendel, Ralf R. and Hercher, Thomas W. and Zupok, Arkadiusz and Hasnat, Muhammad Abrar and Leimk{\"u}hler, Silke}, title = {The requirement of inorganic Fe-S clusters for the biosynthesis of the organometallic molybdenum cofactor}, series = {Inorganics : open access journal}, volume = {8}, journal = {Inorganics : open access journal}, number = {7}, publisher = {MDPI}, address = {Basel}, issn = {2304-6740}, doi = {10.3390/inorganics8070043}, pages = {23}, year = {2020}, abstract = {Iron-sulfur (Fe-S) clusters are essential protein cofactors. In enzymes, they are present either in the rhombic [2Fe-2S] or the cubic [4Fe-4S] form, where they are involved in catalysis and electron transfer and in the biosynthesis of metal-containing prosthetic groups like the molybdenum cofactor (Moco). Here, we give an overview of the assembly of Fe-S clusters in bacteria and humans and present their connection to the Moco biosynthesis pathway. In all organisms, Fe-S cluster assembly starts with the abstraction of sulfur froml-cysteine and its transfer to a scaffold protein. After formation, Fe-S clusters are transferred to carrier proteins that insert them into recipient apo-proteins. In eukaryotes like humans and plants, Fe-S cluster assembly takes place both in mitochondria and in the cytosol. Both Moco biosynthesis and Fe-S cluster assembly are highly conserved among all kingdoms of life. Moco is a tricyclic pterin compound with molybdenum coordinated through its unique dithiolene group. Moco biosynthesis begins in the mitochondria in a Fe-S cluster dependent step involving radical/S-adenosylmethionine (SAM) chemistry. An intermediate is transferred to the cytosol where the dithiolene group is formed, to which molybdenum is finally added. Further connections between Fe-S cluster assembly and Moco biosynthesis are discussed in detail.}, language = {en} } @article{PottsSchlaegel2020, author = {Potts, Jonathan R. and Schl{\"a}gel, Ulrike E.}, title = {Parametrizing diffusion-taxis equations from animal movement trajectories using step selection analysis}, series = {Methods in ecology and evolution : an official journal of the British Ecological Society}, volume = {11}, journal = {Methods in ecology and evolution : an official journal of the British Ecological Society}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {2041-210X}, doi = {10.1111/2041-210X.13406}, pages = {1092 -- 1105}, year = {2020}, abstract = {Mathematical analysis of partial differential equations (PDEs) has led to many insights regarding the effect of organism movements on spatial population dynamics. However, their use has mainly been confined to the community of mathematical biologists, with less attention from statistical and empirical ecologists. We conjecture that this is principally due to the inherent difficulties in fitting PDEs to data. To help remedy this situation, in the context of movement ecology, we show how the popular technique of step selection analysis (SSA) can be used to parametrize a class of PDEs, calleddiffusion-taxismodels, from an animal's trajectory. We examine the accuracy of our technique on simulated data, then demonstrate the utility of diffusion-taxis models in two ways. First, for non-interacting animals, we derive the steady-state utilization distribution in a closed analytic form. Second, we give a recipe for deriving spatial pattern formation properties that emerge from interacting animals: specifically, do those interactions cause heterogeneous spatial distributions to emerge and if so, do these distributions oscillate at short times or emerge without oscillations? The second question is applied to data on concurrently tracked bank volesMyodes glareolus. Our results show that SSA can accurately parametrize diffusion-taxis equations from location data, providing the frequency of the data is not too low. We show that the steady-state distribution of our diffusion-taxis model, where it is derived, has an identical functional form to the utilization distribution given by resource selection analysis (RSA), thus formally linking (fine scale) SSA with (broad scale) RSA. For the bank vole data, we show how our SSA-PDE approach can give predictions regarding the spatial aggregation and segregation of different individuals, which are difficult to predict purely by examining results of SSA. Our methods provide a user-friendly way into the world of PDEs, via a well-used statistical technique, which should lead to tighter links between the findings of mathematical ecology and observations from empirical ecology. By providing a non-speculative link between observed movement behaviours and space use patterns on larger spatio-temporal scales, our findings will also aid integration of movement ecology into understanding spatial species distributions.}, language = {en} } @article{LevyMussackBrunneretal.2020, author = {Levy, Jessica and Mussack, Dominic and Brunner, Martin and Keller, Ulrich and Cardoso-Leite, Pedro and Fischbach, Antoine}, title = {Contrasting classical and machine learning approaches in the estimation of value-added scores in large-scale educational data}, series = {Frontiers in psychology}, volume = {11}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2020.02190}, pages = {18}, year = {2020}, abstract = {There is no consensus on which statistical model estimates school value-added (VA) most accurately. To date, the two most common statistical models used for the calculation of VA scores are two classical methods: linear regression and multilevel models. These models have the advantage of being relatively transparent and thus understandable for most researchers and practitioners. However, these statistical models are bound to certain assumptions (e.g., linearity) that might limit their prediction accuracy. Machine learning methods, which have yielded spectacular results in numerous fields, may be a valuable alternative to these classical models. Although big data is not new in general, it is relatively new in the realm of social sciences and education. New types of data require new data analytical approaches. Such techniques have already evolved in fields with a long tradition in crunching big data (e.g., gene technology). The objective of the present paper is to competently apply these "imported" techniques to education data, more precisely VA scores, and assess when and how they can extend or replace the classical psychometrics toolbox. The different models include linear and non-linear methods and extend classical models with the most commonly used machine learning methods (i.e., random forest, neural networks, support vector machines, and boosting). We used representative data of 3,026 students in 153 schools who took part in the standardized achievement tests of the Luxembourg School Monitoring Program in grades 1 and 3. Multilevel models outperformed classical linear and polynomial regressions, as well as different machine learning models. However, it could be observed that across all schools, school VA scores from different model types correlated highly. Yet, the percentage of disagreements as compared to multilevel models was not trivial and real-life implications for individual schools may still be dramatic depending on the model type used. Implications of these results and possible ethical concerns regarding the use of machine learning methods for decision-making in education are discussed.}, language = {en} }