@article{CostaTomazdeSouzaAyzelHeistermann2020,
  author    = {Costa Tomaz de Souza, Arthur and Ayzel, Georgy and Heistermann, Maik},
  title     = {Quantifying the location error of precipitation nowcasts},
  series = {Advances in meteorology},
  volume    = {2020},
  journal   = {Advances in meteorology},
  publisher = {Hindawi},
  address   = {London},
  issn      = {1687-9309},
  doi       = {10.1155/2020/8841913},
  pages     = {12},
  year      = {2020},
  abstract  = {In precipitation nowcasting, it is common to track the motion of precipitation in a sequence of weather radar images and to extrapolate this motion into the future. The total error of such a prediction consists of an error in the predicted location of a precipitation feature and an error in the change of precipitation intensity over lead time. So far, verification measures did not allow isolating the extent of location errors, making it difficult to specifically improve nowcast models with regard to location prediction. In this paper, we introduce a framework to directly quantify the location error. To that end, we detect and track scale-invariant precipitation features (corners) in radar images. We then consider these observed tracks as the true reference in order to evaluate the performance (or, inversely, the error) of any model that aims to predict the future location of a precipitation feature. Hence, the location error of a forecast at any lead time Delta t ahead of the forecast time t corresponds to the Euclidean distance between the observed and the predicted feature locations at t + Delta t. Based on this framework, we carried out a benchmarking case study using one year worth of weather radar composites of the German Weather Service. We evaluated the performance of four extrapolation models, two of which are based on the linear extrapolation of corner motion from t - 1 to t (LK-Lin1) and t - 4 to t (LK-Lin4) and the other two are based on the Dense Inverse Search (DIS) method: motion vectors obtained from DIS are used to predict feature locations by linear (DIS-Lin1) and Semi-Lagrangian extrapolation (DIS-Rot1). Of those four models, DIS-Lin1 and LK-Lin4 turned out to be the most skillful with regard to the prediction of feature location, while we also found that the model skill dramatically depends on the sinuosity of the observed tracks. The dataset of 376,125 detected feature tracks in 2016 is openly available to foster the improvement of location prediction in extrapolation-based nowcasting models.},
  language  = {en}
}
@article{GrubicWierzba2021,
  author    = {Grubic, Mira and Wierzba, Marta},
  title     = {The German additive particle noch},
  series = {Glossa : a journal of general linguistics},
  volume    = {6},
  journal   = {Glossa : a journal of general linguistics},
  number    = {1},
  publisher = {Ubiquity Press},
  address   = {London},
  issn      = {2397-1835},
  doi       = {10.5334/gjgl.1275},
  pages     = {29},
  year      = {2021},
  abstract  = {The particle noch ('still') can have an additive reading similar to auch ('also'). We argue that both particles indicate that a previously partially answered QUD is re-opened to add a further answer. The particles differ in that the QUD, in the case of auch, can be re-opened with respect to the same topic situation, whereas noch indicates that the QUD is re-opened with respect to a new topic situation. This account predicts a difference in the accommodation behavior of the two particles. We present an experiment whose results are in line with this prediction.},
  language  = {en}
}
@article{MalassTarkhanov2020,
  author    = {Malass, Ihsane and Tarkhanov, Nikolaj Nikolaevič},
  title     = {A perturbation of the de Rham complex},
  series = {Journal of Siberian Federal University : Mathematics \& Physics},
  volume    = {13},
  journal   = {Journal of Siberian Federal University : Mathematics \& Physics},
  number    = {5},
  publisher = {Siberian Federal University},
  address   = {Krasnojarsk},
  issn      = {1997-1397},
  doi       = {10.17516/1997-1397-2020-13-5-519-532},
  pages     = {519 -- 532},
  year      = {2020},
  abstract  = {We consider a perturbation of the de Rham complex on a compact manifold with boundary. This perturbation goes beyond the framework of complexes, and so cohomology does not apply to it. On the other hand, its curvature is "small", hence there is a natural way to introduce an Euler characteristic and develop a Lefschetz theory for the perturbation. This work is intended as an attempt to develop a cohomology theory for arbitrary sequences of linear mappings.},
  language  = {en}
}
@article{TiedemannIobbiNivolLeimkuehler2022,
  author    = {Tiedemann, Kim and Iobbi-Nivol, Chantal and Leimk{\"u}hler, Silke},
  title     = {The Role of the Nucleotides in the Insertion of the bis-Molybdopterin Guanine Dinucleotide Cofactor into apo-Molybdoenzymes},
  series = {Molecules},
  volume    = {27},
  journal   = {Molecules},
  edition   = {9},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {1420-3049},
  doi       = {10.3390/molecules27092993},
  pages     = {1 -- 15},
  year      = {2022},
  abstract  = {The role of the GMP nucleotides of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor of the DMSO reductase family has long been a subject of discussion. The recent characterization of the bis-molybdopterin (bis-Mo-MPT) cofactor present in the E. coli YdhV protein, which differs from bis-MGD solely by the absence of the nucleotides, now enables studying the role of the nucleotides of bis-MGD and bis-MPT cofactors in Moco insertion and the activity of molybdoenzymes in direct comparison. Using the well-known E. coli TMAO reductase TorA as a model enzyme for cofactor insertion, we were able to show that the GMP nucleotides of bis-MGD are crucial for the insertion of the bis-MGD cofactor into apo-TorA.},
  language  = {en}
}
@article{OuerguiDelleliBouassidaetal.2021,
  author    = {Ouergui, Ibrahim and Delleli, Slaheddine and Bouassida, Anissa and Bouhlel, Ezdine and Chaabene, Helmi and Ardig{\`o}, Luca Paolo and Franchini, Emerson},
  title     = {Technical-tactical analysis of small combat games in male kickboxers},
  series = {BMC Sports Science, Medicine and Rehabilitation},
  journal   = {BMC Sports Science, Medicine and Rehabilitation},
  number    = {13},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {2052-1847},
  doi       = {10.1186/s13102-021-00391-0},
  pages     = {8},
  year      = {2021},
  abstract  = {Background: To handle the competition demands, sparring drills are used for specific technical-tactical training as well as physical-physiological conditioning in combat sports. While the effects of different area sizes and number of within-round sparring partners on physiological and perceptive responses in combats sports were examined in previous studies, technical and tactical aspects were not investigated. This study investigated the effect of different within-round sparring partners number (i.e., at a time; 1 vs. 1, 1 vs. 2, and 1 vs. 4) and area sizes (2 m × 2 m, 4 m × 4 m, and 6 m × 6 m) variation on the technical-tactical aspects of small combat games in kickboxing. Method: Twenty male kickboxers (mean ± standard deviation, age: 20.3 ± 0.9 years), regularly competing in regional and national events randomly performed nine different kickboxing combats, lasting 2 min each. All combats were video recorded and analyzed using the software Dartfish. Results: Results showed that the total number of punches was significantly higher in 1 versus 4 compared with 1 versus 1 (p = 0.011, d = 0.83). Further, the total number of kicks was significantly higher in 1 versus 4 compared with 1 versus 1 and 1 versus 2 (p < 0.001; d = 0.99 and d = 0.83, respectively). Moreover, the total number of kick combinations was significantly higher in 1 versus 4 compared with 1 versus 1 and 1 versus 2 (p < 0.001; d = 1.05 and d = 0.95, respectively). The same outcome was significantly lower in 2 m × 2 m compared with 4 m × 4 m and 6 m × 6 m areas (p = 0.010 and d = - 0.45; p < 0.001 and d = - 0.6, respectively). The number of block-and-parry was significantly higher in 1 versus 4 compared with 1 versus 1 (p < 0.001, d = 1.45) and 1 versus 2 (p = 0.046, d = 0.61) and in 2 m × 2 m compared with 4 m × 4 m and 6 × 6 m areas (p < 0.001; d = 0.47 and d = 0.66, respectively). Backwards lean actions occurred more often in 2 m × 2 m compared with 4 m × 4 m (p = 0.009, d = 0.53) and 6 m × 6 m (p = 0.003, d = 0.60). However, the number of foot defenses was significantly lower in 2 m × 2 m compared with 6 m × 6 m (p < 0.001, d = 1.04) and 4 m × 4 m (p = 0.004, d = 0.63). Additionally, the number of clinches was significantly higher in 1 versus 1 compared with 1 versus 2 (p = 0.002, d = 0.7) and 1 versus 4 (p = 0.034, d = 0.45). Conclusions: This study provides practical insights into how to manipulate within-round sparring partners' number and/or area size to train specific kickboxing technical-tactical fundamentals.},
  language  = {en}
}
@misc{YarmanScheller2020,
  author    = {Yarman, Aysu and Scheller, Frieder W.},
  title     = {How reliable is the electrochemical readout of MIP sensors?},
  series = {Sensors},
  volume    = {20},
  journal   = {Sensors},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s20092677},
  pages     = {23},
  year      = {2020},
  abstract  = {Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration.},
  language  = {en}
}
@article{AbdallaAdamAharonianetal.2020,
  author    = {Abdalla, Hassan E. and Adam, Remi and Aharonian, Felix A. and Benkhali, Faical Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, Masanori and Arcaro, C and Armand, Catherine and Armstrong, T. and Egberts, Kathrin},
  title     = {Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance},
  series = {Monthly Notices of the Royal Astronomical Society},
  volume    = {494},
  journal   = {Monthly Notices of the Royal Astronomical Society},
  number    = {4},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  pages     = {13},
  year      = {2020},
  abstract  = {We report on the detection of very high energy (VHE; E > 100 GeV) gamma-ray emission from the BL Lac objects KUV 00311-1938 and PKS 1440-389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE gamma-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311-1938 of z < 0.98 and of PKS 1440-389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311-1938 is constrained to 0.51 <= z < 0.98 and of PKS 1440-389 to 0.14 (sic) z < 0.53.},
  language  = {en}
}
@article{WeithoffBell2022,
  author    = {Weithoff, Guntram and Bell, Elanor Margaret},
  title     = {Complex Trophic Interactions in an Acidophilic Microbial Community},
  series = {Microorganisms},
  volume    = {10},
  journal   = {Microorganisms},
  edition   = {7},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2076-2607},
  doi       = {10.3390/microorganisms10071340},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Extreme habitats often harbor specific communities that differ substantially from non-extreme habitats. In many cases, these communities are characterized by archaea, bacteria and protists, whereas the number of species of metazoa and higher plants is relatively low. In extremely acidic habitats, mostly prokaryotes and protists thrive, and only very few metazoa thrive, for example, rotifers. Since many studies have investigated the physiology and ecology of individual species, there is still a gap in research on direct, trophic interactions among extremophiles. To fill this gap, we experimentally studied the trophic interactions between a predatory protist (Actinophrys sol, Heliozoa) and its prey, the rotifers Elosa woralli and Cephalodella sp., the ciliate Urosomoida sp. and the mixotrophic protist Chlamydomonas acidophila (a green phytoflagellate, Chlorophyta). We found substantial predation pressure on all animal prey. High densities of Chlamydomonas acidophila reduced the predation impact on the rotifers by interfering with the feeding behaviour of A. sol. These trophic relations represent a natural case of intraguild predation, with Chlamydomonas acidophila being the common prey and the rotifers/ciliate and A. sol being the intraguild prey and predator, respectively. We further studied this intraguild predation along a resource gradient using Cephalodella sp. as the intraguild prey. The interactions among the three species led to an increase in relative rotifer abundance with increasing resource (Chlamydomonas) densities. By applying a series of laboratory experiments, we revealed the complexity of trophic interactions within a natural extremophilic community.},
  language  = {en}
}
@article{PrasseIversenLienhardetal.2022,
  author    = {Prasse, Paul and Iversen, Pascal and Lienhard, Matthias and Thedinga, Kristina and Herwig, Ralf and Scheffer, Tobias},
  title     = {Pre-Training on In Vitro and Fine-Tuning on Patient-Derived Data Improves Deep Neural Networks for Anti-Cancer Drug-Sensitivity Prediction},
  series = {MDPI},
  volume    = {14},
  journal   = {MDPI},
  edition   = {16},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14163950},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {Large-scale databases that report the inhibitory capacities of many combinations of candidate drug compounds and cultivated cancer cell lines have driven the development of preclinical drug-sensitivity models based on machine learning. However, cultivated cell lines have devolved from human cancer cells over years or even decades under selective pressure in culture conditions. Moreover, models that have been trained on in vitro data cannot account for interactions with other types of cells. Drug-response data that are based on patient-derived cell cultures, xenografts, and organoids, on the other hand, are not available in the quantities that are needed to train high-capacity machine-learning models. We found that pre-training deep neural network models of drug sensitivity on in vitro drug-sensitivity databases before fine-tuning the model parameters on patient-derived data improves the models' accuracy and improves the biological plausibility of the features, compared to training only on patient-derived data. From our experiments, we can conclude that pre-trained models outperform models that have been trained on the target domains in the vast majority of cases.},
  language  = {en}
}
@article{RajuKoetz2021,
  author    = {Raju, Rajarshi Roy and Koetz, Joachim},
  title     = {Inner rotation of Pickering Janus emulsions},
  series = {Nanomaterials : open access journal},
  volume    = {11},
  journal   = {Nanomaterials : open access journal},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-4991},
  doi       = {10.3390/nano11123312},
  pages     = {6},
  year      = {2021},
  abstract  = {Janus droplets were prepared by vortex mixing of three non-mixable liquids, i.e., olive oil, silicone oil and water, in the presence of gold nanoparticles (AuNPs) in the aqueous phase and magnetite nanoparticles (MNPs) in the olive oil. The resulting Pickering emulsions were stabilized by a red-colored AuNP layer at the olive oil/water interface and MNPs at the oil/oil interface. The core-shell droplets can be stimulated by an external magnetic field. Surprisingly, an inner rotation of the silicon droplet is observed when MNPs are fixed at the inner silicon droplet interface. This is the first example of a controlled movement of the inner parts of complex double emulsions by magnetic manipulation via interfacially confined magnetic nanoparticles.},
  language  = {en}
}