@article{Capra2022,
  author    = {Capra, Elena Sofia},
  title     = {"Orfeo out of Care"},
  series = {thersites 15},
  volume    = {2022},
  journal   = {thersites 15},
  number    = {15},
  editor    = {Amb{\"u}hl, Annemarie and Carl{\`a}-Uhink, Filippo and Rollinger, Christian and Walde, Christine},
  issn      = {2364-7612},
  doi       = {10.34679/thersites.vol15.209},
  pages     = {52 -- 89},
  year      = {2022},
  abstract  = {The paper focuses on an example of multiple-step reception: the contribution of the classical story of Orpheus and Eurydice and the mediaeval lay Sir Orfeo to Tolkien's work. In the first part, I compare the lay with Virgilian and Ovidian versions of Orpheus' myth. This comparison shows the anonymous author's deep knowledge of the ancient texts and complex way of rewriting them through stealing and hybridization. The lay was highly esteemed by Tolkien, who translated it and took inspiration from it while describing the Elven kingdom in The Hobbit and building the storyline of Beren and L{\´u}thien in The Silmarillion. Through this key tale, Orpheus/Orfeo's romance has a deep influence also on Aragorn and Arwen's story in The Lord of the Rings. The most important element that Tolkien takes from the Sir Orfeo figuration of the ancient story is undoubtedly the insertion of political theme: the link established between the recovery of the main character's beloved and the return to royal responsability. The second part of the paper is, thus, dedicated to the reception of Sir Orfeo and the classical myth in Tolkien. It shows how in his work the different steps of the tradition of Orpheus' story are co-present, creating an inextricable substrate of inspiration that nourishes his imagination.},
  language  = {en}
}
@article{Pezzini2022,
  author    = {Pezzini, Giuseppe},
  title     = {(Classical) Narratives of Decline in Tolkien: Renewal, Accommodation, Focalisation},
  series = {thersites 15},
  volume    = {2022},
  journal   = {thersites 15},
  number    = {15},
  editor    = {Amb{\"u}hl, Annemarie and Carl{\`a}-Uhink, Filippo and Rollinger, Christian and Walde, Christine},
  issn      = {2364-7612},
  doi       = {10.34679/thersites.vol15.213},
  pages     = {25 -- 51},
  year      = {2022},
  abstract  = {The paper investigates Tolkien's narratives of decline through the lens of their classical ancestry. Narratives of decline are widespread in ancient culture, in both philosophical and literary discourses. They normally posit a gradual degradation (moral and ontological) from an idealized Golden Age, which went hand-in-hand with increasing detachment of gods from mortal affairs. Narratives of decline are also at the core of Tolkien's mythology, constituting yet another underresearched aspect of classical influence on Tolkien. Such Classical narratives reverberate e.g. in Tolkien's division of Arda's history into ages, from an idealized First Age filled with Joy and Light to a Third Age, described as "Twilight Age (…) the first of the broken and changed world" (Letters 131). More generally, these narratives are related to Tolkien's notorious perception of history as a "long defeat" (Letters 195) and to that "heart-racking sense of the vanished past" which pervades Tolkien's works - the emotion which, in his words, moved him "supremely" and which he found "small difficulty in evoking" (Letters 91). The paper analyses the reception of narratives of decline in Tolkien's legendarium, pointing out similarities but also contrasts and differences, with the aim to discuss some key patterns of (classical) reception in Tolkien's theory and practice ('renewal', 'accommodation', 'focalization').},
  language  = {en}
}
@article{FranzSudoKhomenko2022,
  author    = {Franz, Gerhard and Sudo, Masafumi and Khomenko, Vladimir},
  title     = {40Ar/39Ar dating of a hydrothermal pegmatitic buddingtonite-muscovite assemblage from Volyn, Ukraine},
  series = {European journal of mineralogy : EJM : an international journal on mineralogy, petrology, geochemistry, and related sciences},
  volume    = {34},
  journal   = {European journal of mineralogy : EJM : an international journal on mineralogy, petrology, geochemistry, and related sciences},
  number    = {1},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {0935-1221},
  doi       = {10.5194/ejm-34-7-2022},
  pages     = {7 -- 18},
  year      = {2022},
  abstract  = {We determined Ar-40/Ar-39 ages of buddingtonite, occurring together with muscovite, with the laser-ablation method. This is the first attempt to date the NH4-feldspar buddingtonite, which is typical for sedimentary-diagenetic environments of sediments, rich in organic matter, or in hydrothermal environments, associated with volcanic geyser systems. The sample is a hydrothermal breccia, coming from the Paleoproterozoic pegmatite field of the Korosten Plutonic Complex, Volyn, Ukraine. A detailed characterization by optical methods, electron microprobe analyses, backscattered electron imaging, and IR analyses showed that the buddingtonite consists of euhedral-appearing platy crystals of tens of micrometers wide, 100 or more micrometers in length, which consist of fine-grained fibers of <= 1 mu m thickness. The crystals are sector and growth zoned in terms of K-NH4-H3O content. The content of K allows for an age determination with the Ar-40/Ar-39 method, as well as in the accompanying muscovite, intimately intergrown with the buddingtonite. The determinations on muscovite yielded an age of 1491 +/- 9 Ma, interpreted as the hydrothermal event forming the breccia. However, buddingtonite apparent ages yielded a range of 563 +/- 14 Ma down to 383 +/- 12 Ma, which are interpreted as reset ages due to Ar loss of the fibrous buddingtonite crystals during later heating. We conclude that buddingtonite is suited for Ar-40/Ar-39 age determinations as a supplementary method, together with other methods and minerals; however, it requires a detailed mineralogical characterization, and the ages will likely represent minimum ages.},
  language  = {en}
}
@article{HaueisStechKubick2022,
  author    = {Haueis, Lisa and Stech, Marlitt and Kubick, Stefan},
  title     = {A Cell-free Expression Pipeline for the Generation and Functional Characterization of Nanobodies},
  series = {Frontiers in Bioengineering and Biotechnology},
  volume    = {10},
  journal   = {Frontiers in Bioengineering and Biotechnology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-4185},
  doi       = {10.3389/fbioe.2022.896763},
  pages     = {11},
  year      = {2022},
  abstract  = {Cell-free systems are well-established platforms for the rapid synthesis, screening, engineering and modification of all kinds of recombinant proteins ranging from membrane proteins to soluble proteins, enzymes and even toxins. Also within the antibody field the cell-free technology has gained considerable attention with respect to the clinical research pipeline including antibody discovery and production. Besides the classical full-length monoclonal antibodies (mAbs), so-called "nanobodies" (Nbs) have come into focus. A Nb is the smallest naturally-derived functional antibody fragment known and represents the variable domain (VHH, similar to 15 kDa) of a camelid heavy-chain-only antibody (HCAb). Based on their nanoscale and their special structure, Nbs display striking advantages concerning their production, but also their characteristics as binders, such as high stability, diversity, improved tissue penetration and reaching of cavity-like epitopes. The classical way to produce Nbs depends on the use of living cells as production host. Though cell-based production is well-established, it is still time-consuming, laborious and hardly amenable for high-throughput applications. Here, we present for the first time to our knowledge the synthesis of functional Nbs in a standardized mammalian cell-free system based on Chinese hamster ovary (CHO) cell lysates. Cell-free reactions were shown to be time-efficient and easy-to-handle allowing for the "on demand" synthesis of Nbs. Taken together, we complement available methods and demonstrate a promising new system for Nb selection and validation.},
  language  = {en}
}
@article{KrebsRakotoarinoroStechetal.2022,
  author    = {Krebs, Simon K. and Rakotoarinoro, Nathanael and Stech, Marlitt and Zemella, Anne and Kubick, Stefan},
  title     = {A CHO-based cell-free dual fluorescence reporter system for the straightforward assessment of amber suppression and scFv functionality},
  series = {Frontiers in Bioengineering and Biotechnology},
  volume    = {10},
  journal   = {Frontiers in Bioengineering and Biotechnology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-4185},
  doi       = {10.3389/fbioe.2022.873906},
  pages     = {15},
  year      = {2022},
  abstract  = {Incorporation of noncanonical amino acids (ncAAs) with bioorthogonal reactive groups by amber suppression allows the generation of synthetic proteins with desired novel properties. Such modified molecules are in high demand for basic research and therapeutic applications such as cancer treatment and in vivo imaging. The positioning of the ncAA-responsive codon within the protein's coding sequence is critical in order to maintain protein function, achieve high yields of ncAA-containing protein, and allow effective conjugation. Cell-free ncAA incorporation is of particular interest due to the open nature of cell-free systems and their concurrent ease of manipulation. In this study, we report a straightforward workflow to inquire ncAA positions in regard to incorporation efficiency and protein functionality in a Chinese hamster ovary (CHO) cell-free system. As a model, the well-established orthogonal translation components Escherichia coli tyrosyl-tRNA synthetase (TyrRS) and tRNATyr(CUA) were used to site-specifically incorporate the ncAA p-azido-l-phenylalanine (AzF) in response to UAG codons. A total of seven ncAA sites within an anti-epidermal growth factor receptor (EGFR) single-chain variable fragment (scFv) N-terminally fused to the red fluorescent protein mRFP1 and C-terminally fused to the green fluorescent protein sfGFP were investigated for ncAA incorporation efficiency and impact on antigen binding. The characterized cell-free dual fluorescence reporter system allows screening for ncAA incorporation sites with high incorporation efficiency that maintain protein activity. It is parallelizable, scalable, and easy to operate. We propose that the established CHO-based cell-free dual fluorescence reporter system can be of particular interest for the development of antibody-drug conjugates (ADCs).},
  language  = {en}
}
@article{MbebiBreitlerBordeauxetal.2022,
  author    = {Mbebi, Alain J. and Breitler, Jean-Christophe and Bordeaux, M'elanie and Sulpice, Ronan and McHale, Marcus and Tong, Hao and Toniutti, Lucile and Castillo, Jonny Alonso and Bertrand, Benoit and Nikoloski, Zoran},
  title     = {A comparative analysis of genomic and phenomic predictions of growth-related traits in 3-way coffee hybrids},
  series = {G3: Genes, genomes, genetics},
  volume    = {12},
  journal   = {G3: Genes, genomes, genetics},
  number    = {9},
  publisher = {Genetics Soc. of America},
  address   = {Pittsburgh, PA},
  issn      = {2160-1836},
  doi       = {10.1093/g3journal/jkac170},
  pages     = {11},
  year      = {2022},
  abstract  = {Genomic prediction has revolutionized crop breeding despite remaining issues of transferability of models to unseen environmental conditions and environments. Usage of endophenotypes rather than genomic markers leads to the possibility of building phenomic prediction models that can account, in part, for this challenge. Here, we compare and contrast genomic prediction and phenomic prediction models for 3 growth-related traits, namely, leaf count, tree height, and trunk diameter, from 2 coffee 3-way hybrid populations exposed to a series of treatment-inducing environmental conditions. The models are based on 7 different statistical methods built with genomic markers and ChlF data used as predictors. This comparative analysis demonstrates that the best-performing phenomic prediction models show higher predictability than the best genomic prediction models for the considered traits and environments in the vast majority of comparisons within 3-way hybrid populations. In addition, we show that phenomic prediction models are transferrable between conditions but to a lower extent between populations and we conclude that chlorophyll a fluorescence data can serve as alternative predictors in statistical models of coffee hybrid performance. Future directions will explore their combination with other endophenotypes to further improve the prediction of growth-related traits for crops.},
  language  = {en}
}
@article{ZoccaratoSherMikietal.2022,
  author    = {Zoccarato, Luca and Sher, Daniel and Miki, Takeshi and Segre, Daniel and Grossart, Hans-Peter},
  title     = {A comparative whole-genome approach identifies bacterial traits for marine microbial interactions},
  series = {Communications biology},
  volume    = {5},
  journal   = {Communications biology},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {2399-3642},
  doi       = {10.1038/s42003-022-03184-4},
  pages     = {13},
  year      = {2022},
  abstract  = {Luca Zoccarato, Daniel Sher et al. leverage publicly available bacterial genomes from marine and other environments to examine traits underlying microbial interactions. Their results provide a valuable resource to investigate clusters of functional and linked traits to better understand marine bacteria community assembly and dynamics. Microbial interactions shape the structure and function of microbial communities with profound consequences for biogeochemical cycles and ecosystem health. Yet, most interaction mechanisms are studied only in model systems and their prevalence is unknown. To systematically explore the functional and interaction potential of sequenced marine bacteria, we developed a trait-based approach, and applied it to 473 complete genomes (248 genera), representing a substantial fraction of marine microbial communities. We identified genome functional clusters (GFCs) which group bacterial taxa with common ecology and life history. Most GFCs revealed unique combinations of interaction traits, including the production of siderophores (10\% of genomes), phytohormones (3-8\%) and different B vitamins (57-70\%). Specific GFCs, comprising Alpha- and Gammaproteobacteria, displayed more interaction traits than expected by chance, and are thus predicted to preferentially interact synergistically and/or antagonistically with bacteria and phytoplankton. Linked trait clusters (LTCs) identify traits that may have evolved to act together (e.g., secretion systems, nitrogen metabolism regulation and B vitamin transporters), providing testable hypotheses for complex mechanisms of microbial interactions. Our approach translates multidimensional genomic information into an atlas of marine bacteria and their putative functions, relevant for understanding the fundamental rules that govern community assembly and dynamics.},
  language  = {en}
}
@article{StaufferMengeshaSeifertetal.2022,
  author    = {Stauffer, Maxime and Mengesha, Isaak and Seifert, Konrad and Krawczuk, Igor and Fischer, Jens and Serugendo, Giovanna Di Marzo},
  title     = {A computational turn in policy process studies},
  series = {Complexity},
  volume    = {2022},
  journal   = {Complexity},
  publisher = {Wiley-Hindawi},
  address   = {London},
  issn      = {1076-2787},
  doi       = {10.1155/2022/8210732},
  pages     = {17},
  year      = {2022},
  abstract  = {The past three decades of policy process studies have seen the emergence of a clear intellectual lineage with regard to complexity. Implicitly or explicitly, scholars have employed complexity theory to examine the intricate dynamics of collective action in political contexts. However, the methodological counterparts to complexity theory, such as computational methods, are rarely used and, even if they are, they are often detached from established policy process theory. Building on a critical review of the application of complexity theory to policy process studies, we present and implement a baseline model of policy processes using the logic of coevolving networks. Our model suggests that an actor's influence depends on their environment and on exogenous events facilitating dialogue and consensus-building. Our results validate previous opinion dynamics models and generate novel patterns. Our discussion provides ground for further research and outlines the path for the field to achieve a computational turn.},
  language  = {en}
}
@article{MaierWiljesHartungetal.2022,
  author    = {Maier, Corinna Sabrina and Wiljes, Jana de and Hartung, Niklas and Kloft, Charlotte and Huisinga, Wilhelm},
  title     = {A continued learning approach for model-informed precision dosing},
  series = {CPT: pharmacometrics \& systems pharmacology},
  volume    = {11},
  journal   = {CPT: pharmacometrics \& systems pharmacology},
  number    = {2},
  publisher = {London},
  address   = {Nature Publ. Group},
  issn      = {2163-8306},
  doi       = {10.1002/psp4.12745},
  pages     = {185 -- 198},
  year      = {2022},
  abstract  = {Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment. Structural models and prior parameter distributions used in MIPD approaches typically build on prior clinical trials that involve only a limited number of patients selected according to some exclusion/inclusion criteria. Compared to the prior clinical trial population, the patient population in clinical practice can be expected to also include altered behavior and/or increased interindividual variability, the extent of which, however, is typically unknown. Here, we address the question of how to adapt and refine models on the level of the model parameters to better reflect this real-world diversity. We propose an approach for continued learning across patients during MIPD using a sequential hierarchical Bayesian framework. The approach builds on two stages to separate the update of the individual patient parameters from updating the population parameters. Consequently, it enables continued learning across hospitals or study centers, because only summary patient data (on the level of model parameters) need to be shared, but no individual TDM data. We illustrate this continued learning approach with neutrophil-guided dosing of paclitaxel. The present study constitutes an important step toward building confidence in MIPD and eventually establishing MIPD increasingly in everyday therapeutic use.},
  language  = {en}
}
@article{LangenhanJaegerBaumetal.2022,
  author    = {Langenhan, Jennifer and Jaeger, Carsten and Baum, Katharina and Simon, Mareike and Lisec, Jan},
  title     = {A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments},
  series = {Metabolites},
  volume    = {12},
  journal   = {Metabolites},
  number    = {5},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2218-1989},
  doi       = {10.3390/metabo12050408},
  pages     = {10},
  year      = {2022},
  abstract  = {The investigation of metabolic fluxes and metabolite distributions within cells by means of tracer molecules is a valuable tool to unravel the complexity of biological systems. Technological advances in mass spectrometry (MS) technology such as atmospheric pressure chemical ionization (APCI) coupled with high resolution (HR), not only allows for highly sensitive analyses but also broadens the usefulness of tracer-based experiments, as interesting signals can be annotated de novo when not yet present in a compound library. However, several effects in the APCI ion source, i.e., fragmentation and rearrangement, lead to superimposed mass isotopologue distributions (MID) within the mass spectra, which need to be corrected during data evaluation as they will impair enrichment calculation otherwise. Here, we present and evaluate a novel software tool to automatically perform such corrections. We discuss the different effects, explain the implemented algorithm, and show its application on several experimental datasets. This adjustable tool is available as an R package from CRAN.},
  language  = {en}
}
@article{HeroldLabottGraessleretal.2022,
  author    = {Herold, Fabian and Labott, Berit K. and Gr{\"a}ssler, Bernhard and Halfpaap, Nicole and Langhans, Corinna and M{\"u}ller, Patrick and Ammar, Achraf and Dordevic, Milos and H{\"o}kelmann, Anita and M{\"u}ller, Notger Germar},
  title     = {A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls},
  series = {Healthcare : open access journal},
  volume    = {10},
  journal   = {Healthcare : open access journal},
  edition   = {2},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9032},
  doi       = {10.3390/healthcare10020230},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A\&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.},
  language  = {en}
}
@article{HassaninKliemSeehaferetal.2022,
  author    = {Hassanin, Alshaimaa and Kliem, Bernhard and Seehafer, Norbert and T{\"o}r{\"o}k, Tibor},
  title     = {A model of homologous confined and ejective eruptions involving kink instability and flux cancellation},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {929},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {2},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {2041-8205},
  doi       = {10.3847/2041-8213/ac64a9},
  pages     = {7},
  year      = {2022},
  abstract  = {In this study, we model a sequence of a confined and a full eruption, employing the relaxed end state of the confined eruption of a kink-unstable flux rope as the initial condition for the ejective one. The full eruption, a model of a coronal mass ejection, develops as a result of converging motions imposed at the photospheric boundary, which drive flux cancellation. In this process, parts of the positive and negative external flux converge toward the polarity inversion line, reconnect, and cancel each other. Flux of the same amount as the canceled flux transfers to a flux rope, increasing the free magnetic energy of the coronal field. With sustained flux cancellation and the associated progressive weakening of the magnetic tension of the overlying flux, we find that a flux reduction of approximate to 11\% initiates the torus instability of the flux rope, which leads to a full eruption. These results demonstrate that a homologous full eruption, following a confined one, can be driven by flux cancellation.},
  language  = {en}
}
@article{Brandenburger2022,
  author    = {Brandenburger, Bonny},
  title     = {A multidimensional and analytical perspective on Open Educational Practices in the 21st century},
  series = {Frontiers in education},
  volume    = {7},
  journal   = {Frontiers in education},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2504-284X},
  doi       = {10.3389/feduc.2022.990675},
  pages     = {17},
  year      = {2022},
  abstract  = {Participatory approaches to teaching and learning are experiencing a new lease on life in the 21st century as a result of the rapid technology development. Knowledge, practices, and tools can be shared across spatial and temporal boundaries in higher education by means of Open Educational Resources, Massive Open Online Courses, and open-source technologies. In this context, the Open Education Movement calls for new didactic approaches that encourage greater learner participation in formal higher education. Based on a representative literature review and focus group research, in this study an analytical framework was developed that enables researchers and practitioners to assess the form of participation in formal, collaborative teaching and learning practices. The analytical framework is focused on the micro-level of higher education, in particular on the interaction between students and lecturers when organizing the curriculum. For this purpose, the research reflects anew on the concept of participation, taking into account existing stage models for participation in the educational context. These are then brought together with the dimensions of teaching and learning processes, such as methods, objectives and content, etc. This paper aims to make a valuable contribution to the opening up of learning and teaching, and expands the discourse around possibilities for interpreting Open Educational Practices.},
  language  = {en}
}
@article{JannaschNickelBergmannetal.2022,
  author    = {Jannasch, Franziska and Nickel, Daniela V. and Bergmann, Manuela M. and Schulze, Matthias Bernd},
  title     = {A new evidence-based diet score to capture associations of food consumption and chronic disease risk},
  series = {Nutrients / Molecular Diversity Preservation International (MDPI)},
  volume    = {14},
  journal   = {Nutrients / Molecular Diversity Preservation International (MDPI)},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6643},
  doi       = {10.3390/nu14112359},
  pages     = {16},
  year      = {2022},
  abstract  = {Previously, the attempt to compile German dietary guidelines into a diet score was predominantly not successful with regards to preventing chronic diseases in the EPIC-Potsdam study. Current guidelines were supplemented by the latest evidence from systematic reviews and expert papers published between 2010 and 2020 on the prevention potential of food groups on chronic diseases such as type 2 diabetes, cardiovascular diseases and cancer. A diet score was developed by scoring the food groups according to a recommended low, moderate or high intake. The relative validity and reliability of the diet score, assessed by a food frequency questionnaire, was investigated. The consideration of current evidence resulted in 10 key food groups being preventive of the chronic diseases of interest. They served as components in the diet score and were scored from 0 to 1 point, depending on their recommended intake, resulting in a maximum of 10 points. Both the reliability (r = 0.53) and relative validity (r = 0.43) were deemed sufficient to consider the diet score as a stable construct in future investigations. This new diet score can be a promising tool to investigate dietary intake in etiological research by concentrating on 10 key dietary determinants with evidence-based prevention potential for chronic diseases.},
  language  = {en}
}
@article{VoitHeistermann2022,
  author    = {Voit, Paul and Heistermann, Maik},
  title     = {A new index to quantify the extremeness of precipitation across scales},
  series = {NHESS - Natural Hazards and Earth System Sciences},
  volume    = {22},
  journal   = {NHESS - Natural Hazards and Earth System Sciences},
  edition   = {8},
  publisher = {Copernicus},
  address   = {Katlenburg-Lindau},
  issn      = {1684-9981},
  doi       = {10.5194/nhess-22-2791-2022},
  pages     = {2791 -- 2805},
  year      = {2022},
  abstract  = {Quantifying the extremeness of heavy precipitation allows for the comparison of events. Conventional quantitative indices, however, typically neglect the spatial extent or the duration, while both are important to understand potential impacts. In 2014, the weather extremity index (WEI) was suggested to quantify the extremeness of an event and to identify the spatial and temporal scale at which the event was most extreme. However, the WEI does not account for the fact that one event can be extreme at various spatial and temporal scales. To better understand and detect the compound nature of precipitation events, we suggest complementing the original WEI with a "cross-scale weather extremity index" (xWEI), which integrates extremeness over relevant scales instead of determining its maximum. Based on a set of 101 extreme precipitation events in Germany, we outline and demonstrate the computation of both WEI and xWEI. We find that the choice of the index can lead to considerable differences in the assessment of past events but that the most extreme events are ranked consistently, independently of the index. Even then, the xWEI can reveal cross-scale properties which would otherwise remain hidden. This also applies to the disastrous event from July 2021, which clearly outranks all other analyzed events with regard to both WEI and xWEI. While demonstrating the added value of xWEI, we also identify various methodological challenges along the required computational workflow: these include the parameter estimation for the extreme value distributions, the definition of maximum spatial extent and temporal duration, and the weighting of extremeness at different scales. These challenges, however, also represent opportunities to adjust the retrieval of WEI and xWEI to specific user requirements and application scenarios.},
  language  = {en}
}
@article{KuehnHainzlDahmetal.2022,
  author    = {K{\"u}hn, Daniela and Hainzl, Sebastian and Dahm, Torsten and Richter, Gudrun and Vera Rodriguez, Ismael},
  title     = {A review of source models to further the understanding of the seismicity of the Groningen field},
  series = {Netherlands journal of geosciences : NJG},
  volume    = {101},
  journal   = {Netherlands journal of geosciences : NJG},
  publisher = {Cambridge Univ. Press},
  address   = {Cambridge},
  issn      = {0016-7746},
  doi       = {10.1017/njg.2022.7},
  pages     = {12},
  year      = {2022},
  abstract  = {The occurrence of felt earthquakes due to gas production in Groningen has initiated numerous studies and model attempts to understand and quantify induced seismicity in this region. The whole bandwidth of available models spans the range from fully deterministic models to purely empirical and stochastic models. In this article, we summarise the most important model approaches, describing their main achievements and limitations. In addition, we discuss remaining open questions and potential future directions of development.},
  language  = {en}
}
@techreport{MeyerRichterRichter2022,
  author    = {Meyer, Andr{\´e} and Richter, Eric and Richter, Dirk},
  title     = {Abschlussbericht zur wissenschaftlichen Evaluation der Werkstatt "Schule leiten"},
  doi       = {10.25932/publishup-54886},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-548869},
  pages     = {75},
  year      = {2022},
  abstract  = {Der vorliegende Abschlussbericht umfasst die Ergebnisse der wissenschaftlichen Evaluation der Werkstatt „Schule leiten". Bei dieser Werkstatt handelt es sich um ein 18-monatiges Fortbildungsangebot f{\"u}r Schulleitungen, das durch die Deutsche Schulakademie konzipiert und in Kooperation mit dem saarl{\"a}ndischen Kultusministerium f{\"u}r Bildung und Kultur sowie dem saarl{\"a}ndischen Landesinstitut f{\"u}r P{\"a}dagogik und Medien durchgef{\"u}hrt wurde. Im Zeitraum 2016-2020 absolvierten jeweils zwei Personen des Schulleitungsteams allgemeinbildender Schulen erstmalig in insgesamt drei Durchg{\"a}ngen verschiedene Angebote der Werkstatt. Weiterhin erhielten die Teilnehmenden die Aufgaben, im Zuge ihres Fortbildungsbesuches ein individuelles Schulentwicklungsprojekt zu planen, zu entwickeln und unter Anleitung der Werkstatt in der Schule zu implementieren. Zur {\"U}berpr{\"u}fung der wahrgenommenen Qualit{\"a}t sowie der Wirksamkeit des Fortbildungsangebotes wurde die Universit{\"a}t Potsdam, Arbeitsbereich Prof. Dr. Dirk Richter, beauftragt. Der vorliegende Bericht pr{\"a}sentiert die Evaluationsergebnisse der Durchg{\"a}nge 2 und 3. Im Zentrum der Evaluation stehen die folgenden Forschungsfragen: (1) Wie beurteilen die Teilnehmenden die Qualit{\"a}t der Werkstatt „Schule leiten"? (2) Inwiefern hat die Werkstatt „Schule leiten" dazu beigetragen, die Leitungskompetenzen (u.a. Einstellungen und F{\"u}hrungshandeln) der Teilnehmenden zu st{\"a}rken? sowie (3) Wie haben sich schulische Strukturen und Prozesse zur F{\"o}rderung von Schulentwicklung in den teilnehmenden Schulen durch die Werkstatt „Schule leiten" ver{\"a}ndert? Zur Beantwortung der Fragestellungen wurden eine Reihe schriftlicher Befragungen mit den teilnehmenden Schulleitungen sowie den Lehrkr{\"a}ften der teilnehmenden Schulen durchgef{\"u}hrt. Diese Befragungen erfolgten sowohl begleitend zum Fortbildungsprogramm (nach Absolvieren der einzelnen Angebote) sowie in einem Pr{\"a}-Post-Follow-Up-Design. Weiterhin wurden im Rahmen einer qualitativen Begleitstudie verschiedene Personen (Schulleitung, Mitglieder des Schulleitungsteams, Lehrkr{\"a}fte) von insgesamt f{\"u}nf Schulen {\"u}ber drei Zeitpunkte dazu befragt, wie die Planung, Entwicklung und Implementation der Schulentwicklungsprojekte erfolgten. Die Befunde der Evaluation deuten insgesamt darauf hin, dass die Qualit{\"a}t der Werkstatt „Schule leiten" als Gesamtprogramm sowie die einzelnen Angebote der Werkstatt sehr positiv bewertet werden. Dabei nehmen die Teilnehmenden von Durchgang 2 die Werkstatt in einer Reihe von Merkmalen positiver wahr als die Teilnehmenden von Durchgang 3. Weiterhin deuten die Ergebnisse darauf hin, dass sich bestimmte Facetten des F{\"u}hrungshandelns der Teilnehmenden im zeitlichen Verlauf positiv ver{\"a}ndert haben. Hierf{\"u}r existieren Hinweise sowohl aus Perspektive der Teilnehmenden selbst als auch aus Perspektive der Lehrkr{\"a}fte ihrer Schulen. Motivationale Merkmale der Teilnehmenden sowie Aspekte des F{\"u}hrungshandelns, die sich auf T{\"a}tigkeiten zur Unterst{\"u}tzung der innerschulischen Kooperation beziehen, bleiben aus Perspektive der Teilnehmenden hingegen weitestgehend konstant. Hinsichtlich der Ver{\"a}nderungen schulischer Strukturen zur Schulentwicklung deuten die Ergebnisse auf eine positive Entwicklung der wahrgenommenen Offenheit gegen{\"u}ber Kooperation im Kollegium aus Perspektive der Lehrkr{\"a}fte hin. Die Befunde der qualitativen Begleitstudie liefern weitere Informationen {\"u}ber die wahrgenommene Qualit{\"a}t der Werkstatt sowie {\"u}ber Ver{\"a}nderungen aufseiten der Teilnehmenden und der schulischen Strukturen.},
  language  = {de}
}
@article{GuggenbergerChechkinMetzler2022,
  author    = {Guggenberger, Tobias and Chechkin, Aleksei and Metzler, Ralf},
  title     = {Absence of stationary states and non-Boltzmann distributions of fractional Brownian motion in shallow external potentials},
  series = {New journal of physics : the open-access journal for physics},
  volume    = {24},
  journal   = {New journal of physics : the open-access journal for physics},
  number    = {7},
  publisher = {Dt. Physikalische Ges.},
  address   = {[Bad Honnef]},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ac7b3c},
  pages     = {18},
  year      = {2022},
  abstract  = {We study the diffusive motion of a particle in a subharmonic potential of the form U(x) = |x|( c ) (0 < c < 2) driven by long-range correlated, stationary fractional Gaussian noise xi ( alpha )(t) with 0 < alpha <= 2. In the absence of the potential the particle exhibits free fractional Brownian motion with anomalous diffusion exponent alpha. While for an harmonic external potential the dynamics converges to a Gaussian stationary state, from extensive numerical analysis we here demonstrate that stationary states for shallower than harmonic potentials exist only as long as the relation c > 2(1 - 1/alpha) holds. We analyse the motion in terms of the mean squared displacement and (when it exists) the stationary probability density function. Moreover we discuss analogies of non-stationarity of Levy flights in shallow external potentials.},
  language  = {en}
}
@article{GoeldelKamrathMindenetal.2022,
  author    = {G{\"o}ldel, Julia Marlen and Kamrath, Clemens and Minden, Kirsten and Wiegand, Susanna and Lanzinger, Stefanie and Sengler, Claudia and Weihrauch-Bl{\"u}her, Susann and Holl, Reinhard and Tittel, Sascha Ren{\´e} and Warschburger, Petra},
  title     = {Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany},
  series = {Children},
  volume    = {10},
  journal   = {Children},
  edition   = {1},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9067},
  doi       = {10.3390/children10010010},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {This study examines the access to healthcare for children and adolescents with three common chronic diseases (type-1 diabetes (T1D), obesity, or juvenile idiopathic arthritis (JIA)) within the 4th (Delta), 5th (Omicron), and beginning of the 6th (Omicron) wave (June 2021 until July 2022) of the COVID-19 pandemic in Germany in a cross-sectional study using three national patient registries. A paper-and-pencil questionnaire was given to parents of pediatric patients (<21 years) during the routine check-ups. The questionnaire contains self-constructed items assessing the frequency of healthcare appointments and cancellations, remote healthcare, and satisfaction with healthcare. In total, 905 parents participated in the T1D-sample, 175 in the obesity-sample, and 786 in the JIA-sample. In general, satisfaction with healthcare (scale: 0-10; 10 reflecting the highest satisfaction) was quite high (median values: T1D 10, JIA 10, obesity 8.5). The proportion of children and adolescents with canceled appointments was relatively small (T1D 14.1\%, JIA 11.1\%, obesity 20\%), with a median of 1 missed appointment, respectively. Only a few parents (T1D 8.6\%; obesity 13.1\%; JIA 5\%) reported obstacles regarding health services during the pandemic. To conclude, it seems that access to healthcare was largely preserved for children and adolescents with chronic health conditions during the COVID-19 pandemic in Germany.},
  language  = {en}
}
@article{KrauseGrosseDetersBaumannetal.2022,
  author    = {Krause, Hannes-Vincent and Große Deters, Fenne and Baumann, Annika and Krasnova, Hanna},
  title     = {Active social media use and its impact on well-being},
  series = {Journal of computer-mediated communication : a journal of the International Communication Association},
  volume    = {28},
  journal   = {Journal of computer-mediated communication : a journal of the International Communication Association},
  number    = {1},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {1083-6101},
  doi       = {10.1093/jcmc/zmac037},
  pages     = {12},
  year      = {2022},
  abstract  = {Active use of social networking sites (SNSs) has long been assumed to benefit users' well-being. However, this established hypothesis is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with considerable heterogeneity among existing studies on the hypothesis and causal evidence still limited, a final verdict on its robustness is still pending. To contribute to this ongoing debate, we conducted a week-long randomized control trial with N = 381 adult Instagram users recruited via Prolific. Specifically, we tested how active SNS use, operationalized as picture postings on Instagram, affects different dimensions of well-being. The results depicted a positive effect on users' positive affect but null findings for other well-being outcomes. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs. <br /> Lay Summary Active use of social networking sites (SNSs) has long been assumed to benefit users' well-being. However, this established assumption is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with great diversity among conducted studies on the hypothesis and a lack of causal evidence, a final verdict on its viability is still pending. To contribute to this ongoing debate, we conducted a week-long experimental investigation with 381 adult Instagram users. Specifically, we tested how posting pictures on Instagram affects different aspects of well-being. The results of this study depicted a positive effect of posting Instagram pictures on users' experienced positive emotions but no effects on other aspects of well-being. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs on users.},
  language  = {en}
}
@article{WutzlerHudsonThieken2022,
  author    = {Wutzler, Bianca and Hudson, Paul and Thieken, Annegret},
  title     = {Adaptation strategies of flood-damaged businesses in Germany},
  series = {Frontiers in water},
  volume    = {4},
  journal   = {Frontiers in water},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2624-9375},
  doi       = {10.3389/frwa.2022.932061},
  pages     = {13},
  year      = {2022},
  abstract  = {Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication.},
  language  = {en}
}
@article{WutzlerHudsonThieken2022,
  author    = {Wutzler, Bianca and Hudson, Paul and Thieken, Annegret},
  title     = {Adaptation strategies of flood-damaged businesses in Germany},
  series = {Frontiers in Water},
  journal   = {Frontiers in Water},
  publisher = {Frontiers Media SA},
  address   = {Lausanne, Schweiz},
  issn      = {2624-9375},
  doi       = {10.3389/frwa.2022.932061},
  pages     = {13},
  year      = {2022},
  abstract  = {Flood risk management in Germany follows an integrative approach in which both private households and businesses can make an important contribution to reducing flood damage by implementing property-level adaptation measures. While the flood adaptation behavior of private households has already been widely researched, comparatively less attention has been paid to the adaptation strategies of businesses. However, their ability to cope with flood risk plays an important role in the social and economic development of a flood-prone region. Therefore, using quantitative survey data, this study aims to identify different strategies and adaptation drivers of 557 businesses damaged by a riverine flood in 2013 and 104 businesses damaged by pluvial or flash floods between 2014 and 2017. Our results indicate that a low perceived self-efficacy may be an important factor that can reduce the motivation of businesses to adapt to flood risk. Furthermore, property-owners tended to act more proactively than tenants. In addition, high experience with previous flood events and low perceived response costs could strengthen proactive adaptation behavior. These findings should be considered in business-tailored risk communication.},
  language  = {en}
}
@article{PrieskeChaabeneMoranetal.2022,
  author    = {Prieske, Olaf and Chaabene, Helmi and Moran, Jason and Saeterbakken, Atle Hole},
  title     = {Adaptations to Advanced Resistance Training Strategies in Youth and Adult Athletes},
  series = {Frontiers in physiology / Frontiers Research Foundation},
  volume    = {13},
  journal   = {Frontiers in physiology / Frontiers Research Foundation},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2022.888118},
  pages     = {3},
  year      = {2022},
  language  = {en}
}
@article{FoongPradhanFroeretal.2022,
  author    = {Foong, Adrian and Pradhan, Prajal and Fr{\"o}r, Oliver and Kropp, J{\"u}rgen P.},
  title     = {Adjusting agricultural emissions for trade matters for climate change mitigation},
  series = {Nature Communications},
  volume    = {13},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-022-30607-x},
  pages     = {10},
  year      = {2022},
  abstract  = {Reducing greenhouse gas emissions in food systems is becoming more challenging as food is increasingly consumed away from producer regions, highlighting the need to consider emissions embodied in trade in agricultural emissions accounting. To address this, our study explores recent trends in trade-adjusted agricultural emissions of food items at the global, regional, and national levels. We find that emissions are largely dependent on a country's consumption patterns and their agricultural emission intensities relative to their trading partners'. The absolute differences between the production-based and trade-adjusted emissions accounting approaches are especially apparent for major agricultural exporters and importers and where large shares of emission-intensive items such as ruminant meat, milk products and rice are involved. In relative terms, some low-income and emerging and developing economies with consumption of high emission intensity food products show large differences between approaches. Similar trends are also found under various specifications that account for trade and re-exports differently. These findings could serve as an important element towards constructing national emissions reduction targets that consider trading partners, leading to more effective emissions reductions overall.},
  language  = {en}
}
@article{NeumannTiberiusBiendarra2022,
  author    = {Neumann, Daniel and Tiberius, Victor and Biendarra, Florin},
  title     = {Adopting wearables to customize health insurance contributions},
  series = {BMC medical informatics and decision making},
  volume    = {22},
  journal   = {BMC medical informatics and decision making},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {1472-6947},
  doi       = {10.1186/s12911-022-01851-4},
  pages     = {1 -- 7},
  year      = {2022},
  abstract  = {Background Wearables, as small portable computer systems worn on the body, can track user fitness and health data, which can be used to customize health insurance contributions individually. In particular, insured individuals with a healthy lifestyle can receive a reduction of their contributions to be paid. However, this potential is hardly used in practice. Objective This study aims to identify which barrier factors impede the usage of wearables for assessing individual risk scores for health insurances, despite its technological feasibility, and to rank these barriers according to their relevance. Methods To reach these goals, we conduct a ranking-type Delphi study with the following three stages. First, we collected possible barrier factors from a panel of 16 experts and consolidated them to a list of 11 barrier categories. Second, the panel was asked to rank them regarding their relevance. Third, to enhance the panel consensus, the ranking was revealed to the experts, who were then asked to re-rank the barriers. Results The results suggest that regulation is the most important barrier. Other relevant barriers are false or inaccurate measurements and application errors caused by the users. Additionally, insurers could lack the required technological competence to use the wearable data appropriately. Conclusion A wider use of wearables and health apps could be achieved through regulatory modifications, especially regarding privacy issues. Even after assuring stricter regulations, users' privacy concerns could partly remain, if the data exchange between wearables manufacturers, health app providers, and health insurers does not become more transparent.},
  language  = {en}
}
@article{ZuhrDolmanHoetal.2022,
  author    = {Zuhr, Alexandra M. and Dolman, Andrew M. and Ho, Sze Ling and Groeneveld, Jeroen and Loewemark, Ludvig and Grotheer, Hendrik and Su, Chih-Chieh and Laepple, Thomas},
  title     = {Age-heterogeneity in marine sediments revealed by three-dimensional high-resolution radiocarbon measurements},
  series = {Frontiers in Earth Science},
  volume    = {10},
  journal   = {Frontiers in Earth Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-6463},
  doi       = {10.3389/feart.2022.871902},
  pages     = {15},
  year      = {2022},
  abstract  = {Marine sedimentary archives are routinely used to reconstruct past environmental changes. In many cases, bioturbation and sedimentary mixing affect the proxy time-series and the age-depth relationship. While idealized models of bioturbation exist, they usually assume homogeneous mixing, thus that a single sample is representative for the sediment layer it is sampled from. However, it is largely unknown to which extent this assumption holds for sediments used for paleoclimate reconstructions. To shed light on 1) the age-depth relationship and its full uncertainty, 2) the magnitude of mixing processes affecting the downcore proxy variations, and 3) the representativity of the discrete sample for the sediment layer, we designed and performed a case study on South China Sea sediment material which was collected using a box corer and which covers the last glacial cycle. Using the radiocarbon content of foraminiferal tests as a tracer of time, we characterize the spatial age-heterogeneity of sediments in a three-dimensional setup. In total, 118 radiocarbon measurements were performed on defined small- and large-volume bulk samples ( similar to 200 specimens each) to investigate the horizontal heterogeneity of the sediment. Additionally, replicated measurements on small numbers of specimens (10 x 5 specimens) were performed to assess the heterogeneity within a sample volume. Visual assessment of X-ray images and a quantitative assessment of the mixing strength show typical mixing from bioturbation corresponding to around 10 cm mixing depth. Notably, our 3D radiocarbon distribution reveals that the horizontal heterogeneity (up to 1,250 years), contributing to the age uncertainty, is several times larger than the typically assumed radiocarbon based age-model error (single errors up to 250 years). Furthermore, the assumption of a perfectly bioturbated layer with no mixing underneath is not met. Our analysis further demonstrates that the age-heterogeneity might be a function of sample size; smaller samples might contain single features from the incomplete mixing and are thus less representative than larger samples. We provide suggestions for future studies, optimal sampling strategies for quantitative paleoclimate reconstructions and realistic uncertainty in age models, as well as discuss possible implications for the interpretation of paleoclimate records.},
  language  = {en}
}
@article{MenzeMuellerMuelleretal.2022,
  author    = {Menze, Inga and M{\"u}ller, Patrick and M{\"u}ller, Notger Germar and Schmicker, Marlen},
  title     = {Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Nature portfolio},
  address   = {Berlin},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-11283-9},
  pages     = {16},
  year      = {2022},
  abstract  = {Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health. Here we asked how restriction-related changes influence cognitive performance and how age, perceived loneliness, depressiveness and affectedness by restrictions contribute to these effects. 51 Germans completed three assessments of an online based study during the first lockdown in Germany (April 2020), a month later, and during the beginning of the second lockdown (November 2020). Participants completed nine online cognitive tasks of the MyBrainTraining and online questionnaires about their perceived strain and impact on lifestyle factors by the situation (affectedness), perceived loneliness, depressiveness as well as subjective cognitive performance. The results suggested a possible negative impact of depressiveness and affectedness on objective cognitive performance within the course of the lockdown. The younger the participants, the more pronounced these effects were. Loneliness and depressiveness moreover contributed to a worse evaluation of subjective cognition. In addition, especially younger individuals reported increased distress. As important educational and social input has partly been scarce during this pandemic and mental health problems have increased, future research should also assess cognitive long-term consequences.},
  language  = {en}
}
@misc{Nguyen2022,
  type      = {Master Thesis},
  author    = {Nguyen, Huyen Evelyn},
  title     = {Agilit{\"a}t und F{\"u}hrungskr{\"a}fte-Mitarbeiter-Beziehung in der {\"o}ffentlichen Verwaltung},
  issn      = {2190-4561},
  doi       = {10.25932/publishup-56583},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565831},
  school      = {Universit{\"a}t Potsdam},
  pages     = {VII, 64},
  year      = {2022},
  abstract  = {Zunehmend komplexe Herausforderungen und Aufgaben lassen sich nicht mehr mit den bisherigen Strukturen, Methoden und Prozessen der klassischen Verwaltung bew{\"a}ltigen. Vielmehr gewinnen Ans{\"a}tze und Methoden des New Work im {\"o}ffentlichen Sektor angesichts der sich stetig {\"a}ndernden und dynamischen Arbeitswelt eine immer gr{\"o}ßere Bedeutung. Umso mehr besteht die Notwendigkeit, sich in der Verwaltung agil aufzustellen. Unter Agilit{\"a}t wird hierbei die F{\"a}higkeit einer Organisation verstanden, sich schnell ver{\"a}ndernden Rahmenbedingungen flexibel und dynamisch anzupassen. Im Fokus dieser Arbeit steht der Einfluss von Agilit{\"a}t auf die F{\"u}hrungskr{\"a}fte-Mitarbeiter-Beziehung. Mittels einer halbstandardisierten Online-Befragung im Landesamt f{\"u}r Fl{\"u}chtlingsangelegenheiten und im Bezirksamt Neuk{\"o}lln von Berlin wird zun{\"a}chst der vorliegende Agilit{\"a}tsgrad mit dem Fokus auf agile Organisationsstrukturen, agile Organisationskultur und agile F{\"u}hrung ermittelt und sodann anhand der Qualit{\"a}t der dyadischen Arbeitsbeziehung von F{\"u}hrungskraft und Mitarbeiter (LMX-Qualit{\"a}t) {\"u}berpr{\"u}ft, inwiefern die agile Arbeitsweise im Vergleich zu einer nicht-agilen Arbeitsumgebung die Beziehung beeinflusst. Im Ergebnis der Untersuchung zeigt sich, dass ein positiver Zusammenhang zwischen Agilit{\"a}t und der F{\"u}hrungskr{\"a}fte-Mitarbeiter-Beziehung besteht. Es stellt sich in beiden {\"A}mtern ein m{\"a}ßig bis starker Agilit{\"a}tsgrad heraus, wobei besonders agile F{\"u}hrungseigenschaften zu den wesentlichen Faktoren z{\"a}hlen, die eine hochqualitative Beziehung beg{\"u}nstigen. W{\"a}hrend im Bezirksamt ein Zusammenhang zwischen Agilit{\"a}t und hoher LMX-Qualit{\"a}t ermittelt wurde, konnte dieser nicht f{\"u}r die untersuchte Stichprobe des Landesamts festgestellt werden. Dennoch ließ sich in beiden Beh{\"o}rden ein positiver Einfluss von Agilit{\"a}t auf zumindest die Entwicklung einer erfolgreichen F{\"u}hrungskr{\"a}fte-Mitarbeiter-Beziehung erfassen.},
  language  = {de}
}
@article{ReegStriglJeltsch2022,
  author    = {Reeg, Jette and Strigl, Lea and Jeltsch, Florian},
  title     = {Agricultural buffer zone thresholds to safeguard functional bee diversity},
  series = {Ecology and Evolution},
  volume    = {12},
  journal   = {Ecology and Evolution},
  edition   = {3},
  publisher = {Wiley Online Library},
  address   = {Hoboken, New Jersey, USA},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.8748},
  pages     = {1 -- 17},
  year      = {2022},
  abstract  = {Wild bee species are important pollinators in agricultural landscapes. However, population decline was reported over the last decades and is still ongoing. While agricultural intensification is a major driver of the rapid loss of pollinating species, transition zones between arable fields and forest or grassland patches, i.e., agricultural buffer zones, are frequently mentioned as suitable mitigation measures to support wild bee populations and other pollinator species. Despite the reported general positive effect, it remains unclear which amount of buffer zones is needed to ensure a sustainable and permanent impact for enhancing bee diversity and abundance. To address this question at a pollinator community level, we implemented a process-based, spatially explicit simulation model of functional bee diversity dynamics in an agricultural landscape. More specifically, we introduced a variable amount of agricultural buffer zones (ABZs) at the transition of arable to grassland, or arable to forest patches to analyze the impact on bee functional diversity and functional richness. We focused our study on solitary bees in a typical agricultural area in the Northeast of Germany. Our results showed positive effects with at least 25\% of virtually implemented agricultural buffer zones. However, higher amounts of ABZs of at least 75\% should be considered to ensure a sufficient increase in Shannon diversity and decrease in quasi-extinction risks. These high amounts of ABZs represent effective conservation measures to safeguard the stability of pollination services provided by solitary bee species. As the model structure can be easily adapted to other mobile species in agricultural landscapes, our community approach offers the chance to compare the effectiveness of conservation measures also for other pollinator communities in future.},
  language  = {en}
}
@article{Ette2022,
  author    = {Ette, Ottmar},
  title     = {Alexander von Humboldt im Archiv},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XXIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {45},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2568-3543},
  doi       = {10.25932/publishup-59232},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-592326},
  pages     = {13 -- 28},
  year      = {2022},
  abstract  = {Der Aufsatz erschließt die Anf{\"a}nge, Ergebnisse und Erfolge der editionsphilologischen Arbeit im laufenden Projekt des BBAW-Langzeitvorhabens „Alexander von Humboldt auf Reisen - Wissenschaft aus der Bewegung" und gibt einen {\"U}berblick {\"u}ber die Zuk{\"u}nfte philologischen Arbeitens mit den Methoden der Digital Humanities. Dabei werden auch bibliophile Druckausgaben digitaler Publikationen und die kontinuierliche {\"O}ffentlichkeitsarbeit der Figur Alexander von Humboldts in den Blick genommen, was durch zahlreiche Vernetzungen zwischen Institutionen international gef{\"o}rdert und durch kontinuierliche Kooperationen insbesondere durch das neu gegr{\"u}ndete Humboldt Center for Transdisciplinary Studies (HCTS) in China/Changsha erweitert wird. Diskutiert wird die wissenschaftliche Bedeutung der graphischen und visuellen Dimension des Humboldt'schen Archivs, die durch die digitale Aufbereitung des Materials Forscher:innen weltweit miteinander verbindet und neue Forschungskonzepte er{\"o}ffnet.},
  language  = {de}
}
@article{Korneffel2022,
  author    = {Korneffel, Peter},
  title     = {Alexander von Humboldt postfrisch},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XXIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {44},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.25932/publishup-58943},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-589433},
  pages     = {59 -- 82},
  year      = {2022},
  abstract  = {Seit 1950 erschienen weltweit {\"u}ber hundert Briefmarken mit Alexander von Humboldt und/oder seinen grafischen Arbeiten als Motive. Peter Korneffel verarbeitete die komplette Sammlung der Marken aus {\"u}ber 25 L{\"a}ndern zu dem Buch Alexander von Humboldt. Weltmarken sowie zu mehreren philatelistischen Ausstellungen und Vortr{\"a}gen. Der Festvortrag vom 5.9.2019 in Berlin zum offiziellen Erscheinen der Sonderbriefmarke 250. Geburtstag Alexander von Humboldt bildet die Grundlage zu diesem Beitrag. Die Motive, ihre Gestaltung, ihre thematische Kontextualisierung, sowie die Herausgeber und die Zeitpunkte des Erscheinens der jeweiligen Briefmarken dokumentieren eine teils zuf{\"a}llige und teils {\"u}berraschende Humboldt-Rezeption. Recherchierte Hintergr{\"u}nde zu den Ausgaben und Illustrationen vertiefen hierin eine bislang weitestgehend unbekannte Rezeptionsgeschichte.},
  language  = {de}
}
@article{SchulzLuepertz2022,
  author    = {Schulz-L{\"u}pertz, Eberhard},
  title     = {Alexander von Humboldt und Ulrich Jasper Seetzen},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XXIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {44},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.25932/publishup-58987},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-589870},
  pages     = {95 -- 130},
  year      = {2022},
  abstract  = {Die beiden Forschungsreisenden Alexander von Humboldt und Ulrich Jasper Seetzen haben sich w{\"a}hrend der gemeinsamen Studienzeit in G{\"o}ttingen kennengelernt und sich dort {\"u}ber ihre Arbeiten zur Naturkunde ausgetauscht. Sp{\"a}ter brach Seetzen, wie Humboldt, zu einer großen Expedition auf, die ihn als ersten Europ{\"a}er durch das zentrale Afrika f{\"u}hren sollte. Seine Forschungen im Nahen Osten gelten bis heute als Pionierleistungen der Orientalistik. Das Unternehmen fand auf der arabischen Halbinsel ein vorzeitiges, tragisches Ende. {\"U}ber die Beziehung der beiden Kommilitonen w{\"a}hrend ihrer G{\"o}ttinger Zeit war bislang wenig bekannt. Ein k{\"u}rzlich entdecktes Brieffragment erm{\"o}glicht neue Einblicke. Es erweist sich als eine Abschrift Seetzens aus einem bislang unbekannten Brief des einundzwanzigj{\"a}hrigen Humboldt {\"u}ber dessen Helgolandreise 1790. Im Zusammenhang mit weiteren Quellen kann diese Jugendfreundschaft nun besser bewertet werden.},
  language  = {de}
}
@article{BadePicatChungetal.2022,
  author    = {Bade, Nadine and Picat, Leo and Chung, WooJin and Mascarenhas, Salvador},
  title     = {Alternatives and attention in language and reasoning: A reply to Mascarenhas \& Picat (2019)},
  series = {Semantics and Pragmatics},
  volume    = {15},
  journal   = {Semantics and Pragmatics},
  publisher = {Linguistic Society of America},
  address   = {Washington},
  issn      = {1937-8912},
  doi       = {10.3765/sp.15.2},
  pages     = {31},
  year      = {2022},
  abstract  = {In this paper, we employ an experimental paradigm using insights from the psychology of reasoning to investigate the question whether certain modals generate and draw attention to alternatives. The article extends and builds on the methodology and findings of Mascarenhas \& Picat (2019). Based on experimental results, they argue that the English epistemic modal might raises alternatives. We apply the same methodology to the English modal allowed to to test different hypotheses regarding the involvement of alternatives in deontic modality. We find commonalities and differences between the two modals we tested. We discuss theoretical consequences for existing semantic analyses of these modals, and argue that reasoning tasks can serve as a diagnostic tool to discover which natural language expressions involve alternatives.},
  language  = {en}
}
@article{WarschburgerWortmannGischetal.2022,
  author    = {Warschburger, Petra and Wortmann, Hanna Rosalie and Gisch, Ulrike Alexandra and Baer, Nadja-Raphaela and Schenk, Liane and Anton, Verena and Bergmann, Manuela M.},
  title     = {An experimental approach to training interoceptive sensitivity},
  series = {Nutrition Journal},
  volume    = {21},
  journal   = {Nutrition Journal},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {1475-2891},
  doi       = {10.1186/s12937-022-00827-4},
  pages     = {16},
  year      = {2022},
  abstract  = {Background Eating in absence of hunger is quite common and often associated with an increased energy intake co-existent with a poorer food choice. Intuitive eating (IE), i.e., eating in accordance with internal hunger and satiety cues, may protect from overeating. IE, however, requires accurate perception and processing of one's own bodily signals, also referred to as interoceptive sensitivity. Training interoceptive sensitivity might therefore be an effective method to promote IE and prevent overeating. As most studies on eating behavior are conducted in younger adults and close social relationships influence health-related behavior, this study focuses on middle-aged and older couples. Methods The present pilot randomized intervention study aims at investigating the feasibility and effectiveness of a 21-day mindfulness-based training program designed to increase interoceptive sensitivity. A total of N = 60 couples participating in the NutriAct Family Study, aged 50-80 years, will be recruited. This randomized-controlled intervention study comprises three measurement points (pre-intervention, post-intervention, 4-week follow-up) and a 21-day training that consists of daily mindfulness-based guided audio exercises (e.g., body scan). A three-arm intervention study design is applied to compare two intervention groups (training together as a couple vs. training alone) with a control group (no training). Each measurement point includes the assessment of self-reported and objective indicators of interoceptive sensitivity (primary outcome), self-reported indicators of intuitive and maladaptive eating (secondary outcomes), and additional variables. A training evaluation applying focus group discussions will be conducted to assess participants' overall acceptance of the training and its feasibility. Discussion By investigating the feasibility and effectiveness of a mindfulness-based training program to increase interoceptive sensitivity, the present study will contribute to a deeper understanding of how to promote healthy eating in older age.},
  language  = {en}
}
@article{HoanRichterBorsigetal.2022,
  author    = {Hoan, Tran Viet and Richter, Karl-Gerd and Borsig, Nicolas and Bauer, Jonas and Ha, Nguyen Thi and Norra, Stefan},
  title     = {An improved groundwater model framework for aquifer structures of the quaternary-formed sediment body in the southernmost parts of the Mekong Delta, Vietnam},
  series = {Hydrology : open access journal},
  volume    = {9},
  journal   = {Hydrology : open access journal},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2306-5338},
  doi       = {10.3390/hydrology9040061},
  pages     = {20},
  year      = {2022},
  abstract  = {The Ca Mau peninsula (CMP) is a key economic region in southern Vietnam. In recent decades, the high demand for water has increased the exploitation of groundwater, thus lowering the groundwater level and leading to risks of degradation, depletion, and land subsidence, as well as salinity intrusion in the groundwater of the whole Mekong Delta region. By using a finite element groundwater model with boundary expansion to the sea, we updated the latest data on hydrogeological profiles, groundwater levels, and exploitation. The basic model setup covers seven aquifers and seven aquitards. It is determined that the inflow along the coastline to the mainland is 39\% of the total inflow. The exploitation of the study area in 2019 was 567,364 m(3)/day. The most exploited aquifers are the upper-middle Pleistocene (qp(2-3)) and the middle Pliocene (n(2)(2)), accounting for 63.7\% and 24.6\%, respectively; the least exploited aquifers are the upper Pleistocene and the upper Miocene, accounting for 0.35\% and 0.02\%, respectively. In the deeper aquifers, qp(2-3) and n(2)(2), the change in storage is negative due to the high exploitation rate, leading to a decline in the reserves of these aquifers. These groundwater model results are the calculations of groundwater reserves from the coast to the mainland in the entire system of aquifers in the CMP. This makes groundwater decision managers, stakeholders, and others more efficient in sustainable water resources planning in the CMP and Mekong Delta (MKD).},
  language  = {en}
}
@article{ArkesAbereggArpin2022,
  author    = {Arkes, Hal R. and Aberegg, Scott K. and Arpin, Kevin A.},
  title     = {Analysis of physicians' probability estimates of a medical outcome based on a sequence of events},
  series = {JAMA network open / American Medical Association},
  volume    = {5},
  journal   = {JAMA network open / American Medical Association},
  number    = {6},
  publisher = {American Veterinary Medical Association},
  address   = {Chicago},
  issn      = {2574-3805},
  doi       = {10.1001/jamanetworkopen.2022.18804},
  pages     = {10},
  year      = {2022},
  abstract  = {IMPORTANCE The probability of a conjunction of 2 independent events is the product of the probabilities of the 2 components and therefore cannot exceed the probability of either component; violation of this basic law is called the conjunction fallacy. A common medical decision-making scenario involves estimating the probability of a final outcome resulting from a sequence of independent events; however, little is known about physicians' ability to accurately estimate the overall probability of success in these situations. OBJECTIVE To ascertain whether physicians are able to correctly estimate the overall probability of a medical outcome resulting from 2 independent events. DESIGN, SETTING, AND PARTICIPANTS This survey study consisted of 3 separate substudies, in which 215 physicians were asked via internet-based survey to estimate the probability of success of each of 2 components of a diagnostic or prognostic sequence as well as the overall probability of success of the 2-step sequence. Substudy 1 was performed from April 2 to 4, 2021, substudy 2 from November 2 toll, 2021, and substudy 3 from May 13 to 19, 2021. All physicians were board certified or board eligible in the primary specialty germane to the substudy (ie, obstetrics and gynecology for substudies land 3 and pulmonology for substudy 2), were recruited from a commercial survey service, and volunteered to participate in the study. EXPOSURES Case scenarios presented in an online survey. MAIN OUTCOMES AND MEASURES Respondents were asked to provide their demographic information in addition to 3 probability estimates. The first substudy included a scenario describing a brow presentation discovered during labor; the 2 conjuncts were the probabilities that the brow presentation would resolve and that the delivery would be vaginal. The second substudy involved a diagnostic evaluation of an incidentally discovered pulmonary nodule; the 2 conjuncts were the probabilities that the patient had a malignant condition and that a technically successful transthoracic needle biopsy would reveal a malignant condition. The third substudy included a modification of the first substudy in an attempt to debias the conjunction fallacy prevalent in the first substudy. Respondents' own probability estimates of the individual events were used to calculate the mathematically correct conjunctive probability. RESULTS Among 215 respondents, the mean (SD) age was 54.0 (9.5) years; 142 respondents (66.0\%) were male. Data on race and ethnicity were not collected. A total of 168 physicians (78.1\%) estimated the probability of the 2-step sequence to be greater than the probability of at least 1 of the 2 component events. Compared with the product of their 2 estimated components, respondents overestimated the combined probability by 12.8\% (95\% CI, 9.6\%-16.1\%; P < .001) in substudy 1, 19.8\% (95\% Cl, 16.6\%-23.0\%; P < .001) in substudy 2, and 18.0\% (95\% CI, 13.4\%-22.5\%; P < .001) in substudy 3, results that were mathematically incoherent (ie, formally illogical and mathematically incorrect). CONCLUSIONS AND RELEVANCE In this survey study of 215 physicians, respondents consistently overestimated the combined probability of 2 events compared with the probability calculated from their own estimates of the individual events. This biased estimation, consistent with the conjunction fallacy, may have substantial implications for diagnostic and prognostic decision-making.},
  language  = {en}
}
@article{DieterichLindemannMoskoppetal.2022,
  author    = {Dieterich, Peter and Lindemann, Otto and Moskopp, Mats Leif and Tauzin, Sebastien and Huttenlocher, Anna and Klages, Rainer and Chechkin, Aleksei V. and Schwab, Albrecht},
  title     = {Anomalous diffusion and asymmetric tempering memory in neutrophil chemotaxis},
  series = {PLoS Computational Biology : a new community journal},
  volume    = {18},
  journal   = {PLoS Computational Biology : a new community journal},
  number    = {5},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1553-734X},
  doi       = {10.1371/journal.pcbi.1010089},
  pages     = {26},
  year      = {2022},
  abstract  = {Neutrophil granulocytes are essential for the first host defense. After leaving the blood circulation they migrate efficiently towards sites of inflammation. They are guided by chemoattractants released from cells within the inflammatory foci. On a cellular level, directional migration is a consequence of cellular front-rear asymmetry which is induced by the concentration gradient of the chemoattractants. The generation and maintenance of this asymmetry, however, is not yet fully understood. Here we analyzed the paths of chemotacting neutrophils with different stochastic models to gain further insight into the underlying mechanisms. Wildtype chemotacting neutrophils show an anomalous superdiffusive behavior. CXCR2 blockade and TRPC6-knockout cause the tempering of temporal correlations and a reduction of chemotaxis. Importantly, such tempering is found both in vitro and in vivo. These findings indicate that the maintenance of anomalous dynamics is crucial for chemotactic behavior and the search efficiency of neutrophils. The motility of neutrophils and their ability to sense and to react to chemoattractants in their environment are of central importance for the innate immunity. Neutrophils are guided towards sites of inflammation following the activation of G-protein coupled chemoattractant receptors such as CXCR2 whose signaling strongly depends on the activity of Ca2+ permeable TRPC6 channels. It is the aim of this study to analyze data sets obtained in vitro (murine neutrophils) and in vivo (zebrafish neutrophils) with a stochastic mathematical model to gain deeper insight into the underlying mechanisms. The model is based on the analysis of trajectories of individual neutrophils. Bayesian data analysis, including the covariances of positions for fractional Brownian motion as well as for exponentially and power-law tempered model variants, allows the estimation of parameters and model selection. Our model-based analysis reveals that wildtype neutrophils show pure superdiffusive fractional Brownian motion. This so-called anomalous dynamics is characterized by temporal long-range correlations for the movement into the direction of the chemotactic CXCL1 gradient. Pure superdiffusion is absent vertically to this gradient. This points to an asymmetric 'memory' of the migratory machinery, which is found both in vitro and in vivo. CXCR2 blockade and TRPC6-knockout cause tempering of temporal correlations in the chemotactic gradient. This can be interpreted as a progressive loss of memory, which leads to a marked reduction of chemotaxis and search efficiency of neutrophils. In summary, our findings indicate that spatially differential regulation of anomalous dynamics appears to play a central role in guiding efficient chemotactic behavior.},
  language  = {en}
}
@article{IlicicWoodhouseKarstenetal.2022,
  author    = {Ilicic, Doris and Woodhouse, Jason Nicholas and Karsten, Ulf and Zimmermann, Jonas and Wichard, Thomas and Quartino, Maria Liliana and Campana, Gabriela Laura and Livenets, Alexandra and Van den Wyngaert, Silke and Grossart, Hans-Peter},
  title     = {Antarctic Glacial Meltwater Impacts the Diversity of Fungal Parasites Associated With Benthic Diatoms in Shallow Coastal Zones},
  series = {Frontiers in microbiology},
  journal   = {Frontiers in microbiology},
  number    = {13},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-302X},
  doi       = {10.3389/fmicb.2022.805694},
  pages     = {12},
  year      = {2022},
  abstract  = {Aquatic ecosystems are frequently overlooked as fungal habitats, although there is increasing evidence that their diversity and ecological importance are greater than previously considered. Aquatic fungi are critical and abundant components of nutrient cycling and food web dynamics, e.g., exerting top-down control on phytoplankton communities and forming symbioses with many marine microorganisms. However, their relevance for microphytobenthic communities is almost unexplored. In the light of global warming, polar regions face extreme changes in abiotic factors with a severe impact on biodiversity and ecosystem functioning. Therefore, this study aimed to describe, for the first time, fungal diversity in Antarctic benthic habitats along the salinity gradient and to determine the co-occurrence of fungal parasites with their algal hosts, which were dominated by benthic diatoms. Our results reveal that Ascomycota and Chytridiomycota are the most abundant fungal taxa in these habitats. We show that also in Antarctic waters, salinity has a major impact on shaping not just fungal but rather the whole eukaryotic community composition, with a diversity of aquatic fungi increasing as salinity decreases. Moreover, we determined correlations between putative fungal parasites and potential benthic diatom hosts, highlighting the need for further systematic analysis of fungal diversity along with studies on taxonomy and ecological roles of Chytridiomycota.},
  language  = {en}
}
@incollection{Balderjahn2022,
  author    = {Balderjahn, Ingo},
  title     = {Anti-Consumption und Nachhaltigkeit},
  series = {Marke, Nachhaltigkeit und Verbraucherpolitik : Die Gew{\"a}hrleistungsmarke im Spannungsfeld zwischen Unternehmen, Konsumenten und Regulierung},
  booktitle = {Marke, Nachhaltigkeit und Verbraucherpolitik : Die Gew{\"a}hrleistungsmarke im Spannungsfeld zwischen Unternehmen, Konsumenten und Regulierung},
  editor    = {Boltz, Dirk-Mario and Bruhn, Manfred and Gr{\"o}ppel-Klein, Andrea and Hellmann, Kai-Uwe},
  publisher = {Nomos},
  address   = {Baden-Baden},
  isbn      = {978-3-7489-1271-2},
  doi       = {10.5771/9783748912712-29},
  pages     = {29 -- 40},
  year      = {2022},
  language  = {de}
}
@article{HerrmannBodenMaureretal.2022,
  author    = {Herrmann, Matthias L. and Boden, Cindy and Maurer, Christoph and Kentischer, Felix and Mennig, Eva and Wagner, S{\"o}ren and Conzelmann, Lars O. and F{\"o}rstner, Bernd R. and Rapp, Michael A. and von Arnim, Christine A. F. and Denkinger, Michael and Eschweiler, Gerhard W. and Thomas, Christine},
  title     = {Anticholinergic drug exposure increases the risk of delirium in older patients undergoing elective surgery},
  series = {Frontiers in medicine},
  volume    = {9},
  journal   = {Frontiers in medicine},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-858X},
  doi       = {10.3389/fmed.2022.871229},
  pages     = {8},
  year      = {2022},
  abstract  = {IntroductionPostoperative delirium (POD) is a common and serious adverse event of surgery in older people. Because of its great impact on patients' safety and quality of life, identification of modifiable risk factors could be useful. Although preoperative medication intake is assumed to be an important modifiable risk factor, the impact of anticholinergic drugs on the occurrence of POD seems underestimated in elective surgery. The aim of this study was to investigate the association between preoperative anticholinergic burden and POD. We hypothesized that a high preoperative anticholinergic burden is an independent, potentially modifiable predisposing and precipitating factor of POD in older people. MethodsBetween November 2017 and April 2019, 1,470 patients of 70 years and older undergoing elective orthopedic, general, cardiac, or vascular surgery were recruited in the randomized, prospective, multicenter PAWEL trial. Anticholinergic burden of a sub-cohort of 899 patients, who did not receive a multimodal intervention for preventing POD, was assessed by two different tools at hospital admission: The established Anticholinergic Risk Scale (ARS) and the recently developed Anticholinergic Burden Score (ABS). POD was detected by confusion assessment method (CAM) and a validated post discharge medical record review. Logistic regression analyses were performed to evaluate the association between anticholinergic burden and POD. ResultsPOD was observed in 210 of 899 patients (23.4\%). Both ARS and ABS were independently associated with POD. The association persisted after adjustment for relevant confounding factors such as age, sex, comorbidities, preoperative cognitive and physical status, number of prescribed drugs, surgery time, type of surgery and anesthesia, usage of heart-lung-machine, and treatment in intensive care unit. If a patient was taking one of the 56 drugs listed in the ABS, risk for POD was 2.7-fold higher (OR = 2.74, 95\% CI = 1.55-4.94) and 1.5-fold higher per additional point on the ARS (OR = 1.54, 95\% CI = 1.15-2.02). ConclusionPreoperative anticholinergic drug exposure measured by ARS or ABS was independently associated with POD in older patients undergoing elective surgery. Therefore, identification, discontinuation or substitution of anticholinergic medication prior to surgery may be a promising approach to reduce the risk of POD in older patients.},
  language  = {en}
}
@article{Huelsenberg2022,
  author    = {H{\"u}lsenberg, Dagmar},
  title     = {Anwendung naturwissenschaftlicher und kameralistischer Erkenntnisse auf die Verarbeitung von Rohstoffen durch den jungen Alexander von Humboldt},
  series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  volume    = {XXIII},
  journal   = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies},
  number    = {44},
  editor    = {Ette, Ottmar and Knobloch, Eberhard},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1617-5239},
  doi       = {10.25932/publishup-58936},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-589363},
  pages     = {33 -- 57},
  year      = {2022},
  abstract  = {Alexander von Humboldt geh{\"o}rt zu den ersten Fachleuten, die f{\"u}r die sichere Beherrschung technischer und {\"o}konomischer Prozesse gleichzeitig naturwissenschaftliche und kameralistische Kenntnisse anwendeten und dabei weiterentwickelten. Durch die allseitige Betrachtung von Herstellungsvorg{\"a}ngen gelang es ihm, f{\"u}r seine Vorgesetzten gut durchdachte Vorschl{\"a}ge zur Gestaltung der Rohstoffverarbeitung zu formulieren. Nach einigen Fakten aus seinem kameralistischen und h{\"u}ttenm{\"a}nnischen Studium wird das anhand von Beispielen belegt. Dazu geh{\"o}ren u. a. die Anlage von Gradierwerken, der Einsatz hochwertiger Rohstoffe in der Steingutfertigung, die Anwendung von Komplexrohstoffen zur Glasschmelze, die Auswahl effektiver Wasserr{\"a}der, die Dimensionierung der Gaskan{\"a}le in Porzellanbrenn{\"o}fen sowie der Einsatz von Flussmitteln f{\"u}r die Roheisenschmelze. Bei der Ausreichung eines k{\"o}niglichen Kredites f{\"u}r die Blaufarbenherstellung zeigte sich der Kameralist.},
  language  = {de}
}
@article{HuelscherSobelKallniketal.2022,
  author    = {H{\"u}lscher, Julian and Sobel, Edward and Kallnik, Niklas and Hoffmann, J. Elis and Millar, Ian L. and Hartmann, Kai and Bernhardt, Anne},
  title     = {Apatites record sedimentary provenance change 4-5 myrs before clay in the Oligocene/Miocene Alpine molasse},
  series = {Frontiers in Earth Science},
  volume    = {10},
  journal   = {Frontiers in Earth Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-6463},
  doi       = {10.3389/feart.2022.914409},
  pages     = {16},
  year      = {2022},
  abstract  = {Extracting information about past tectonic or climatic environmental changes from sedimentary records is a key objective of provenance research. Interpreting the imprint of such changes remains challenging as signals might be altered in the sediment-routing system. We investigate the sedimentary provenance of the Oligocene/Miocene Upper Austrian Northern Alpine Foreland Basin and its response to the tectonically driven exhumation of the Tauern Window metamorphic dome (28 +/- 1 Ma) in the Eastern European Alps by using the unprecedented combination of Nd isotopic composition of bulk-rock clay-sized samples and partly previously published multi-proxy (Nd isotopic composition, trace-element geochemistry, U-Pb dating) sand-sized apatite single-grain analysis. The basin offers an excellent opportunity to investigate environmental signal propagation into the sedimentary record because comprehensive stratigraphic and seismic datasets can be combined with present research results. The bulk-rock clay-sized fraction epsilon Nd values of well-cutting samples from one well on the northern basin slope remained stable at similar to-9.7 from 27 to 19 Ma but increased after 19 Ma to similar to-9.1. In contrast, apatite single-grain distributions, which were extracted from 22 drill-core samples, changed significantly around 23.3 Ma from apatites dominantly from low-grade (<upper amphibolite-facies) metamorphic sources with Permo-Mesozoic and late Variscan U-Pb ages and epsilon Nd values of -4.4 to dominantly high-grade metamorphic apatites with late Variscan U-Pb ages and epsilon Nd values of -2.2. The change in apatite single-grain distributions at 23.3 Ma is interpreted to result from the exposure of a new Upper Austroalpine source nappe with less negative epsilon Nd values triggered by the ongoing Tauern Window exhumation. Combining these data with the clay-sized bulk-rock epsilon Nd values reveals that the provenance changed 4-5 Myrs later at 19 Ma in the clay-sized fraction. Reasons for the delayed provenance-change recording are rooted in the characteristics of the applied methods. Whereas single-grain distributions of orogen-wide sediment-routing systems can be dominated by geographically small areas with high erosion and mineral fertility rates, bulk-rock methods integrate over the entire drainage basin, thus diminishing extreme values. Hence, by combining these two methods, spatial information are uncovered, enabling a previously unattained understanding of the underlying environmental change.},
  language  = {en}
}
@article{WochatzSchraplauEngeletal.2022,
  author    = {Wochatz, Monique and Schraplau, Anne and Engel, Tilman and Zecher, Mahli Megan and Sharon, Hadar and Alt, Yasmin and Mayer, Frank and Kalron, Alon},
  title     = {Application of eccentric training in various clinical populations},
  series = {PLoS ONE},
  volume    = {17},
  journal   = {PLoS ONE},
  number    = {12},
  publisher = {Public Library of Science},
  address   = {San Francisco, California, USA},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0270875},
  pages     = {15},
  year      = {2022},
  abstract  = {Physical activity and exercise are effective approaches in prevention and therapy of multiple diseases. Although the specific characteristics of lengthening contractions have the potential to be beneficial in many clinical conditions, eccentric training is not commonly used in clinical populations with metabolic, orthopaedic, or neurologic conditions. The purpose of this pilot study is to investigate the feasibility, functional benefits, and systemic responses of an eccentric exercise program focused on the trunk and lower extremities in people with low back pain (LBP) and multiple sclerosis (MS). A six-week eccentric training program with three weekly sessions is performed by people with LBP and MS. The program consists of ten exercises addressing strength of the trunk and lower extremities. The study follows a four-group design (N = 12 per group) in two study centers (Israel and Germany): three groups perform the eccentric training program: A) control group (healthy, asymptomatic); B) people with LBP; C) people with MS; group D (people with MS) receives standard care physiotherapy. Baseline measurements are conducted before first training, post-measurement takes place after the last session both comprise blood sampling, self-reported questionnaires, mobility, balance, and strength testing. The feasibility of the eccentric training program will be evaluated using quantitative and qualitative measures related to the study process, compliance and adherence, safety, and overall program assessment. For preliminary assessment of potential intervention effects, surrogate parameters related to mobility, postural control, muscle strength and systemic effects are assessed. The presented study will add knowledge regarding safety, feasibility, and initial effects of eccentric training in people with orthopaedic and neurological conditions. The simple exercises, that are easily modifiable in complexity and intensity, are likely beneficial to other populations. Thus, multiple applications and implementation pathways for the herein presented training program are conceivable.},
  language  = {en}
}
@article{RadosavljevicLantuitKnoblauchetal.2022,
  author    = {Radosavljevic, Boris and Lantuit, Hugues and Knoblauch, Christian and Couture, Nicole and Herzschuh, Ulrike and Fritz, Michael},
  title     = {Arctic nearshore sediment dynamics - an example from Herschel Island - Qikiqtaruk, Canada},
  series = {Journal of marine science and engineering},
  volume    = {10},
  journal   = {Journal of marine science and engineering},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2077-1312},
  doi       = {10.3390/jmse10111589},
  pages     = {18},
  year      = {2022},
  abstract  = {Increasing arctic coastal erosion rates imply a greater release of sediments and organic matter into the coastal zone. With 213 sediment samples taken around Herschel Island-Qikiqtaruk, Canadian Beaufort Sea, we aimed to gain new insights on sediment dynamics and geochemical properties of a shallow arctic nearshore zone. Spatial characteristics of nearshore sediment texture (moderately to poorly sorted silt) are dictated by hydrodynamic processes, but ice-related processes also play a role. We determined organic matter (OM) distribution and inferred the origin and quality of organic carbon by C/N ratios and stable carbon isotopes delta C-13. The carbon content was higher offshore and in sheltered areas (mean: 1.0 wt.\%., S.D.: 0.9) and the C/N ratios also showed a similar spatial pattern (mean: 11.1, S.D.: 3.1), while the delta C-13 (mean: -26.4 parts per thousand VPDB, S.D.: 0.4) distribution was more complex. We compared the geochemical parameters of our study with terrestrial and marine samples from other studies using a bootstrap approach. Sediments of the current study contained 6.5 times and 1.8 times less total organic carbon than undisturbed and disturbed terrestrial sediments, respectively. Therefore, degradation of OM and separation of carbon pools take place on land and continue in the nearshore zone, where OM is leached, mineralized, or transported beyond the study area.},
  language  = {en}
}
@article{RolphOverduinRavensetal.2022,
  author    = {Rolph, Rebecca and Overduin, Pier Paul and Ravens, Thomas and Lantuit, Hugues and Langer, Moritz},
  title     = {ArcticBeach v1.0},
  series = {Frontiers in Earth Science},
  volume    = {10},
  journal   = {Frontiers in Earth Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-6463},
  doi       = {10.3389/feart.2022.962208},
  pages     = {19},
  year      = {2022},
  abstract  = {In the Arctic, air temperatures are increasing and sea ice is declining, resulting in larger waves and a longer open water season, all of which intensify the thaw and erosion of ice-rich coasts. Climate change has been shown to increase the rate of Arctic coastal erosion, causing problems for Arctic cultural heritage, existing industrial, military, and civil infrastructure, as well as changes in nearshore biogeochemistry. Numerical models that reproduce historical and project future Arctic erosion rates are necessary to understand how further climate change will affect these problems, and no such model yet exists to simulate the physics of erosion on a pan-Arctic scale. We have coupled a bathystrophic storm surge model to a simplified physical erosion model of a permafrost coastline. This Arctic erosion model, called ArcticBeach v1.0, is a first step toward a physical parameterization of Arctic shoreline erosion for larger-scale models. It is forced by wind speed and direction, wave period and height, sea surface temperature, all of which are masked during times of sea ice cover near the coastline. Model tuning requires observed historical retreat rates (at least one value), as well as rough nearshore bathymetry. These parameters are already available on a pan-Arctic scale. The model is validated at three study sites at 1) Drew Point (DP), Alaska, 2) Mamontovy Khayata (MK), Siberia, and 3) Veslebogen Cliffs, Svalbard. Simulated cumulative retreat rates for DP and MK respectively (169 and 170 m) over the time periods studied at each site (2007-2016, and 1995-2018) are found to the same order of magnitude as observed cumulative retreat (172 and 120 m). The rocky Veslebogen cliffs have small observed cumulative retreat rates (0.05 m over 2014-2016), and our model was also able to reproduce this same order of magnitude of retreat (0.08 m). Given the large differences in geomorphology between the study sites, this study provides a proof-of-concept that ArcticBeach v1.0 can be applied on very different permafrost coastlines. ArcticBeach v1.0 provides a promising starting point to project retreat of Arctic shorelines, or to evaluate historical retreat in places that have had few observations.},
  language  = {en}
}
@article{HoffmannOttRaupbachetal.2022,
  author    = {Hoffmann, Holger and Ott, Christiane and Raupbach, Jana and Andernach, Lars and Renz, Matthias and Grune, Tilman and Hanschen, Franziska S.},
  title     = {Assessing bioavailability and bioactivity of 4-Hydroxythiazolidine-2-Thiones, newly discovered glucosinolate degradation products formed during domestic boiling of cabbage},
  series = {Frontiers in nutrition},
  volume    = {9},
  journal   = {Frontiers in nutrition},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-861X},
  doi       = {10.3389/fnut.2022.941286},
  pages     = {13},
  year      = {2022},
  abstract  = {Glucosinolates are plant secondary metabolites found in cruciferous vegetables (Brassicaceae) that are valued for their potential health benefits. Frequently consumed representatives of these vegetables, for example, are white or red cabbage, which are typically boiled before consumption. Recently, 3-alk(en)yl-4-hydroxythiazolidine-2-thiones were identified as a class of thermal glucosinolate degradation products that are formed during the boiling of cabbage. Since these newly discovered compounds are frequently consumed, this raises questions about their potential uptake and their possible bioactive functions. Therefore, 3-allyl-4-hydroxythiazolidine-2-thione (allyl HTT) and 4-hydroxy-3-(4-(methylsulfinyl) butyl)thiazolidine-2-thione (4-MSOB HTT) as degradation products of the respective glucosinolates sinigrin and glucoraphanin were investigated. After consumption of boiled red cabbage broth, recoveries of consumed amounts of the degradation products in urine collected for 24 h were 18 +/- 5\% for allyl HTT and 21 +/- 4\% for 4-MSOB HTT (mean +/- SD, n = 3). To investigate the stability of the degradation products during uptake and to elucidate the uptake mechanism, both an in vitro stomach and an in vitro intestinal model were applied. The results indicate that the uptake of allyl HTT and 4-MSOB HTT occurs by passive diffusion. Both compounds show no acute cell toxicity, no antioxidant potential, and no change in NAD(P)H dehydrogenase quinone 1 (NQO1) activity up to 100 mu M. However, inhibition of glycogen synthase kinases-3 (GSK-3) in the range of 20\% for allyl HTT for the isoform GSK-3 beta and 29\% for 4-MSOB HTT for the isoform GSK-3 alpha at a concentration of 100 mu M was found. Neither health-promoting nor toxic effects of 3-alk(en)yl-4-hydroxythiazolidine-2-thiones were found in the four tested assays carried out in this study, which contrasts with the properties of other glucosinolate degradation products, such as isothiocyanates.},
  language  = {en}
}
@article{JesusSchmidtFickeletal.2022,
  author    = {Jesus, Sonia A. and Schmidt, Anke and Fickel, J{\"o}rns and Doherr, Marcus G. and Boonprasert, Khajohnpat and Thitaram, Chatchote and Sariya, Ladawan and Ratanakron, Parntep and Hildebrandt, Thomas Bernd},
  title     = {Assessing coagulation parameters in healthy Asian Elephants (Elephas maximus) from European and thai populations},
  series = {Animals},
  volume    = {12},
  journal   = {Animals},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2076-2615},
  doi       = {10.3390/ani12030361},
  pages     = {16},
  year      = {2022},
  abstract  = {Simple Summary Asian elephants (Elephas maximus) are considered endangered and their population is in continuous decline. Understanding their social interactions, health, and welfare status has been a topic of intense research in recent decades. Coagulation assessments have been underutilized in wildlife but can give valuable information on individual health. This study aims to increase the knowledge of the coagulation status in healthy Asian elephants from different backgrounds and age groups, using a fast point-of-care analyzer. This tool can be further used in either routine health check-ups performed by caretakers or in a clinical emergency, such as in cases of elephant endotheliotropic herpesvirus hemorrhagic disease outbreaks. We have also investigated the presence of genomic mutations in one coagulation factor-factor VII-where a disorder was previously reported in an Asian elephant. Hereby, we report new reference values for coagulation parameters, such as coagulation times and fibrinogen concentration of Asian elephants assessed in Thailand and in Europe, as well as several single point mutations found in the exons of Elephas maximus coagulation F7 gene. We found the point-of-care analyzer used in this study to be very practical and user friendly for a zoo and field environment and hope that this project will incentivize further coagulation studies in Asian elephants and in other wildlife species. The Asian elephant population is continuously declining due to several extrinsic reasons in their range countries, but also due to diseases in captive populations worldwide. One of these diseases, the elephant endotheliotropic herpesvirus (EEHV) hemorrhagic disease, is very impactful because it particularly affects Asian elephant calves. It is commonly fatal and presents as an acute and generalized hemorrhagic syndrome. Therefore, having reference values of coagulation parameters, and obtaining such values for diseased animals in a very short time, is of great importance. We analyzed prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen concentrations using a portable and fast point-of-care analyzer (VetScan Pro) in 127 Asian elephants from Thai camps and European captive herds. We found significantly different PT and aPTT coagulation times between elephants from the two regions, as well as clear differences in fibrinogen concentration. Nevertheless, these alterations were not expected to have biological or clinical implications. We have also sequenced the coagulation factor VII gene of 141 animals to assess the presence of a previously reported hereditary coagulation disorder in Asian elephants and to investigate the presence of other mutations. We did not find the previously reported mutation in our study population. Instead, we discovered the presence of several new single nucleotide polymorphisms, two of them being considered as deleterious by effect prediction software.},
  language  = {en}
}
@article{HeinzeWeckKuehne2022,
  author    = {Heinze, Peter Eric and Weck, Florian and K{\"u}hne, Franziska},
  title     = {Assessing patient preferences},
  series = {Frontiers in psychology},
  volume    = {12},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2021.795776},
  pages     = {10},
  year      = {2022},
  abstract  = {Despite the positive effects of including patients' preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP.},
  language  = {en}
}
@article{HeinzeWeckKuehne2022,
  author    = {Heinze, Peter Eric and Weck, Florian and K{\"u}hne, Franziska},
  title     = {Assessing Patient Preferences},
  series = {Frontiers in Psychology},
  volume    = {12},
  journal   = {Frontiers in Psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2021.795776},
  pages     = {10},
  year      = {2022},
  abstract  = {Despite the positive effects of including patients' preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP.},
  language  = {en}
}
@article{FanselowZimmermannPhilipp2022,
  author    = {Fanselow, Gisbert and Zimmermann, Malte and Philipp, Mareike},
  title     = {Assessing the availability of inverse scope in German in the covered box paradigm},
  series = {Glossa : a journal of general linguistics},
  volume    = {7},
  journal   = {Glossa : a journal of general linguistics},
  number    = {1},
  publisher = {Open Library of Humanities},
  address   = {London},
  issn      = {2397-1835},
  doi       = {10.16995/glossa.5766},
  pages     = {1 -- 24},
  year      = {2022},
  abstract  = {This paper presents the results of a novel experimental approach to relative quantifier scope in German that elicits data in an indirect manner. Applying the covered-box method (Huang et al. 2013) to scope phenomena, we show that inverse scope is available to some extent in the free constituent order language German, thereby validating earlier findings on other syntactic configurations in German (Rado \& Bott 2018) and empirical claims on other free constituent order languages (Japanese, Russian, Hindi), as well as recent corpus findings in Webelhuth (2020). Moreover, the results of the indirect covered-box experiment replicate findings from an earlier direct-query experiment with comparable target items, in which participants were asked directly about the availability of surface scope and inverse scope readings. The configuration of interest consisted of canonical transitive clauses with deaccented existential subject and universal object QPs, in which the restriction of the universal QP was controlled for by the context.},
  language  = {en}
}
@article{FranckeHeistermannKoehlietal.2022,
  author    = {Francke, Till and Heistermann, Maik and K{\"o}hli, Markus and Budach, Christian and Schr{\"o}n, Martin and Oswald, Sascha},
  title     = {Assessing the feasibility of a directional cosmic-ray neutron sensing sensor for estimating soil moisture},
  series = {Geoscientific Instrumentation, Methods and Data Systems},
  volume    = {11},
  journal   = {Geoscientific Instrumentation, Methods and Data Systems},
  publisher = {Copernicus Publ.},
  address   = {G{\"o}ttingen},
  issn      = {2193-0864},
  doi       = {10.5194/gi-11-75-2022},
  pages     = {75 -- 92},
  year      = {2022},
  abstract  = {Cosmic-ray neutron sensing (CRNS) is a non-invasive tool for measuring hydrogen pools such as soil moisture, snow or vegetation. The intrinsic integration over a radial hectare-scale footprint is a clear advantage for averaging out small-scale heterogeneity, but on the other hand the data may become hard to interpret in complex terrain with patchy land use. This study presents a directional shielding approach to prevent neutrons from certain angles from being counted while counting neutrons entering the detector from other angles and explores its potential to gain a sharper horizontal view on the surrounding soil moisture distribution. Using the Monte Carlo code URANOS (Ultra Rapid Neutron-Only Simulation), we modelled the effect of additional polyethylene shields on the horizontal field of view and assessed its impact on the epithermal count rate, propagated uncertainties and aggregation time. The results demonstrate that directional CRNS measurements are strongly dominated by isotropic neutron transport, which dilutes the signal of the targeted direction especially from the far field. For typical count rates of customary CRNS stations, directional shielding of half-spaces could not lead to acceptable precision at a daily time resolution. However, the mere statistical distinction of two rates should be feasible.},
  language  = {en}
}
@article{PohlMaciasColemanetal.2022,
  author    = {Pohl, Martin and Macias, Oscar and Coleman, Phaedra and Gordon, Chris},
  title     = {Assessing the impact of hydrogen absorption on the characteristics of the Galactic center excess},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {929},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {2},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {0004-637X},
  doi       = {10.3847/1538-4357/ac6032},
  pages     = {13},
  year      = {2022},
  abstract  = {We present a new reconstruction of the distribution of atomic hydrogen in the inner Galaxy that is based on explicit radiation transport modeling of line and continuum emission and a gas-flow model in the barred Galaxy that provides distance resolution for lines of sight toward the Galactic center. The main benefits of the new gas model are (a) the ability to reproduce the negative line signals seen with the HI4PI survey and (b) the accounting for gas that primarily manifests itself through absorption. We apply the new model of Galactic atomic hydrogen to an analysis of the diffuse gamma-ray emission from the inner Galaxy, for which an excess at a few GeV was reported that may be related to dark matter. We find with high significance an improved fit to the diffuse gamma-ray emission observed with the Fermi-LAT, if our new H i model is used to estimate the cosmic-ray induced diffuse gamma-ray emission. The fit still requires a nuclear bulge at high significance. Once this is included there is no evidence of a dark-matter signal, be it cuspy or cored. But an additional so-called boxy bulge is still favored by the data. This finding is robust under the variation of various parameters, for example, the excitation temperature of atomic hydrogen, and a number of tests for systematic issues.},
  language  = {en}
}
@article{PawlakNoetzelDragoetal.2022,
  author    = {Pawlak, Julia and Noetzel, Dominique Christian and Drago, Claudia and Weithoff, Guntram},
  title     = {Assessing the toxicity of polystyrene beads and silica particles on the microconsumer Brachionus calyciflorus at different timescales},
  series = {Frontiers in Environmental Science},
  journal   = {Frontiers in Environmental Science},
  publisher = {Frontiers},
  address   = {Lausanne, Schweiz},
  issn      = {2296-665X},
  doi       = {10.3389/fenvs.2022.955425},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {Environmental pollution by microplastics has become a severe problem in terrestrial and aquatic ecosystems and, according to actual prognoses, problems will further increase in the future. Therefore, assessing and quantifying the risk for the biota is crucial. Standardized short-term toxicological procedures as well as methods quantifying potential toxic effects over the whole life span of an animal are required. We studied the effect of the microplastic polystyrene on the survival and reproduction of a common freshwater invertebrate, the rotifer Brachionus calyciflorus, at different timescales. We used pristine polystyrene spheres of 1, 3, and 6 µm diameter and fed them to the animals together with food algae in different ratios ranging from 0 to 50\% nonfood particles. As a particle control, we used silica to distinguish between a pure particle effect and a plastic effect. After 24 h, no toxic effect was found, neither with polystyrene nor with silica. After 96 h, a toxic effect was detectable for both particle types. The size of the particles played a negligible role. Studying the long-term effect by using life table experiments, we found a reduced reproduction when the animals were fed with 3 µm spheres together with similar-sized food algae. We conclude that the fitness reduction is mainly driven by the dilution of food by the nonfood particles rather than by a direct toxic effect.},
  language  = {en}
}
@article{HenschkeKaplickWochatzetal.2022,
  author    = {Henschke, Jakob and Kaplick, Hannes and Wochatz, Monique and Engel, Tilman},
  title     = {Assessing the validity of inertial measurement units for shoulder kinematics using a commercial sensor-software system},
  series = {Health science reports},
  volume    = {5},
  journal   = {Health science reports},
  number    = {5},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2398-8835},
  doi       = {10.1002/hsr2.772},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {Background and Aims Wearable inertial sensors may offer additional kinematic parameters of the shoulder compared to traditional instruments such as goniometers when elaborate and time-consuming data processing procedures are undertaken. However, in clinical practice simple-real time motion analysis is required to improve clinical reasoning. Therefore, the aim was to assess the criterion validity between a portable "off-the-shelf" sensor-software system (IMU) and optical motion (Mocap) for measuring kinematic parameters during active shoulder movements. Methods 24 healthy participants (9 female, 15 male, age 29 +/- 4 years, height 177 +/- 11 cm, weight 73 +/- 14 kg) were included. Range of motion (ROM), total range of motion (TROM), peak and mean angular velocity of both systems were assessed during simple (abduction/adduction, horizontal flexion/horizontal extension, vertical flexion/extension, and external/internal rotation) and complex shoulder movements. Criterion validity was determined using intraclass-correlation coefficients (ICC), root mean square error (RMSE) and Bland and Altmann analysis (bias; upper and lower limits of agreement). Results ROM and TROM analysis revealed inconsistent validity during simple (ICC: 0.040-0.733, RMSE: 9.7 degrees-20.3 degrees, bias: 1.2 degrees-50.7 degrees) and insufficient agreement during complex shoulder movements (ICC: 0.104-0.453, RMSE: 10.1 degrees-23.3 degrees, bias: 1.0 degrees-55.9 degrees). Peak angular velocity (ICC: 0.202-0.865, RMSE: 14.6 degrees/s-26.7 degrees/s, bias: 10.2 degrees/s-29.9 degrees/s) and mean angular velocity (ICC: 0.019-0.786, RMSE:6.1 degrees/s-34.2 degrees/s, bias: 1.6 degrees/s-27.8 degrees/s) were inconsistent. Conclusions The "off-the-shelf" sensor-software system showed overall insufficient agreement with the gold standard. Further development of commercial IMU-software-solutions may increase measurement accuracy and permit their integration into everyday clinical practice.},
  language  = {en}
}
@article{BenNsirJomaaYildirimetal.2022,
  author    = {Ben Nsir, Siwar and Jomaa, Seifeddine and Yildirim, Umit and Zhou, Xiangqian and D'Oria, Marco and Rode, Michael and Khlifi, Slaheddine},
  title     = {Assessment of climate change impact on discharge of the lakhmass catchment (Northwest Tunisia)},
  series = {Water},
  volume    = {14},
  journal   = {Water},
  number    = {14},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4441},
  doi       = {10.3390/w14142242},
  pages     = {17},
  year      = {2022},
  abstract  = {The Mediterranean region is increasingly recognized as a climate change hotspot but is highly underrepresented in hydrological climate change studies. This study aims to investigate the climate change effects on the hydrology of Lakhmass catchment in Tunisia. Lakhmass catchment is a part of the Medium Valley of Medjerda in northwestern Tunisia that drains an area of 126 km(2). First, the Hydrologiska Byrans Vattenbalansavdelning light (HBV-light) model was calibrated and validated successfully at a daily time step to simulate discharge during the 1981-1986 period. The Nash Sutcliffe Efficiency and Percent bias (NSE, PBIAS) were (0.80, +2.0\%) and (0.53, -9.5\%) for calibration (September 1982-August 1984) and validation (September 1984-August 1986) periods, respectively. Second, HBV-light model was considered as a predictive tool to simulate discharge in a baseline period (1981-2009) and future projections using data (precipitation and temperature) from thirteen combinations of General Circulation Models (GCMs) and Regional Climatic Models (RCMs). We used two trajectories of Representative Concentration Pathways, RCP4.5 and RCP8.5, suggested by the Intergovernmental Panel on Climate Change (IPCC). Each RCP is divided into three projection periods: near-term (2010-2039), mid-term (2040-2069) and long-term (2070-2099). For both scenarios, a decrease in precipitation and discharge will be expected with an increase in air temperature and a reduction in precipitation with almost 5\% for every +1 degrees C of global warming. By long-term (2070-2099) projection period, results suggested an increase in temperature with about 2.7 degrees C and 4 degrees C, and a decrease in precipitation of approximately 7.5\% and 15\% under RCP4.5 and RCP8.5, respectively. This will likely result in a reduction of discharge of 12.5\% and 36.6\% under RCP4.5 and RCP8.5, respectively. This situation calls for early climate change adaptation measures under a participatory approach, including multiple stakeholders and water users.},
  language  = {en}
}
@article{OseiBlockWippert2022,
  author    = {Osei, Francis and Block, Andrea and Wippert, Pia-Maria},
  title     = {Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review},
  series = {Frontiers in Endocrinology},
  volume    = {13},
  journal   = {Frontiers in Endocrinology},
  publisher = {Frontiers},
  address   = {Lausanne, Schweiz},
  issn      = {1664-2392},
  doi       = {10.3389/fendo.2022.946740},
  pages     = {16},
  year      = {2022},
  abstract  = {Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case-control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case-control studies. The included studies had a completeness of reporting score of COR \% = 87.0 ± 6.4\%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50\% (urinary cortisol), 40\% (serum cortisol), 60\% (salivary cortisol), and 100\% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60\% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100\% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS.},
  language  = {en}
}
@article{WachsMachimbarrenaWrightetal.2022,
  author    = {Wachs, Sebastian and Machimbarrena, Juan Manuel and Wright, Michelle F. and G{\´a}mez-Guadix, Manuel and Yang, Soeun and Sittichai, Ruthaychonnee and Singh, Ritu and Biswal, Ramakrishna and Flora, Katerina and Daskalou, Vassiliki and Maziridou, Evdoxia and Sung Hong, Jun and Krause, Norman},
  title     = {Associations between coping strategies and cyberhate involvement},
  series = {International journal of environmental research and public health},
  volume    = {19},
  journal   = {International journal of environmental research and public health},
  edition   = {11},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph19116749},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {Cyberhate represents a risk to adolescents' development and peaceful coexistence in democratic societies. Yet, not much is known about the relationship between adolescents' ability to cope with cyberhate and their cyberhate involvement. To fill current gaps in the literature and inform the development of media education programs, the present study investigated various coping strategies in a hypothetical cyberhate scenario as correlates for being cyberhate victims, perpetrators, and both victim-perpetrators. The sample consisted of 6829 adolescents aged 12-18 years old (Mage = 14.93, SD = 1.64; girls: 50.4\%, boys: 48.9\%, and 0.7\% did not indicate their gender) from Asia, Europe, and North America. Results showed that adolescents who endorsed distal advice or endorsed technical coping showed a lower likelihood to be victims, perpetrators, or victim-perpetrators. In contrast, if adolescents felt helpless or endorsed retaliation to cope with cyberhate, they showed higher odds of being involved in cyberhate as victims, perpetrators, or victim-perpetrators. Finally, adolescents who endorsed close support as a coping strategy showed a lower likelihood to be victim-perpetrators, and adolescents who endorsed assertive coping showed higher odds of being victims. In conclusion, the results confirm the importance of addressing adolescents' ability to deal with cyberhate to develop more tailored prevention approaches. More specifically, such initiatives should focus on adolescents who feel helpless or feel inclined to retaliate. In addition, adolescents should be educated to practice distal advice and technical coping when experiencing cyberhate. Implications for the design and instruction of evidence-based cyberhate prevention (e.g., online educational games, virtual learning environments) will be discussed.},
  language  = {en}
}
@article{WickKriemlerGranacher2022,
  author    = {Wick, Kristin and Kriemler, Susi and Granacher, Urs},
  title     = {Associations between measures of physical fitness and cognitive performance in preschool children},
  series = {BMC sports science, medicine \& rehabilitation},
  volume    = {14},
  journal   = {BMC sports science, medicine \& rehabilitation},
  number    = {1},
  publisher = {BMC},
  address   = {London},
  issn      = {2052-1847},
  doi       = {10.1186/s13102-022-00470-w},
  pages     = {8},
  year      = {2022},
  abstract  = {Background: Given that recent studies report negative secular declines in physical fitness, associations between fitness and cognition in childhood are strongly discussed. The preschool age is characterized by high neuroplasticity which effects motor skill learning, physical fitness, and cognitive development. The aim of this study was to assess the relation of physical fitness and attention (including its individual dimensions (quantitative, qualitative)) as one domain of cognitive performance in preschool children. We hypothesized that fitness components which need precise coordination compared to simple fitness components are stronger related to attention. Methods: Physical fitness components like static balance (i.e., single-leg stance), muscle strength (i.e., handgrip strength), muscle power (i.e., standing long jump), and coordination (i.e., hopping on one leg) were assessed in 61 healthy children (mean age 4.5 +/- 0.6 years; girls n = 30). Attention was measured with the "Konzentrations-Handlungsverfahren fur Vorschulkinder" [concentration-action procedure for preschoolers]). Analyses were adjusted for age, body height, and body mass. Results: Results from single linear regression analysis revealed a significant (p < 0.05) association between physical fitness (composite score) and attention (composite score) (standardized ss = 0.40), showing a small to medium effect (F-2 = 0.14). Further, coordination had a significant relation with the composite score and the quantitative dimension of attention (standardized ss = 0.35; p < 0.01; standardized ss = - 0.33; p < 0.05). Coordination explained about 11\% (composite score) and 9\% (quantitative dimension) of the variance in the stepwise multiple regression model. Conclusion: The results indicate that performance in physical fitness, particularly coordination, is related to attention in preschool children. Thus, high performance in complex fitness components (i.e., hopping on one leg) tends to predict attention in preschool children. Further longitudinal studies should focus on the effectiveness of physical activity programs implementing coordination and complex exercises at preschool age to examine cause-effect relationships between physical fitness and attention precisely.},
  language  = {en}
}
@article{PadashSandevKantzetal.2022,
  author    = {Padash, Amin and Sandev, Trifce and Kantz, Holger and Metzler, Ralf and Chechkin, Aleksei},
  title     = {Asymmetric Levy flights are more efficient in random search},
  series = {Fractal and fractional},
  volume    = {6},
  journal   = {Fractal and fractional},
  number    = {5},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2504-3110},
  doi       = {10.3390/fractalfract6050260},
  pages     = {23},
  year      = {2022},
  abstract  = {We study the first-arrival (first-hitting) dynamics and efficiency of a one-dimensional random search model performing asymmetric Levy flights by leveraging the Fokker-Planck equation with a delta-sink and an asymmetric space-fractional derivative operator with stable index alpha and asymmetry (skewness) parameter beta. We find exact analytical results for the probability density of first-arrival times and the search efficiency, and we analyse their behaviour within the limits of short and long times. We find that when the starting point of the searcher is to the right of the target, random search by Brownian motion is more efficient than Levy flights with beta <= 0 (with a rightward bias) for short initial distances, while for beta>0 (with a leftward bias) Levy flights with alpha -> 1 are more efficient. When increasing the initial distance of the searcher to the target, Levy flight search (except for alpha=1 with beta=0) is more efficient than the Brownian search. Moreover, the asymmetry in jumps leads to essentially higher efficiency of the Levy search compared to symmetric Levy flights at both short and long distances, and the effect is more pronounced for stable indices alpha close to unity.},
  language  = {en}
}
@article{Dieter2022,
  author    = {Dieter, Heribert},
  title     = {AUKUS und die strukturellen Ver{\"a}nderungen der sicherheitspolitischen Lage im indo-pazifischen Raum},
  series = {SIRIUS - Zeitschrift f{\"u}r Strategische Analysen},
  volume    = {6},
  journal   = {SIRIUS - Zeitschrift f{\"u}r Strategische Analysen},
  number    = {2},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2510-263X},
  doi       = {10.1515/sirius-2022-2007},
  pages     = {210 -- 217},
  year      = {2022},
  language  = {de}
}
@article{Martin2022,
  author    = {Martin, Angela},
  title     = {Ausgebeutet, diskriminiert, aber dringend gebraucht},
  series = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  journal   = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-506-4},
  doi       = {10.25932/publishup-54685},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-546850},
  pages     = {193 -- 208},
  year      = {2022},
  language  = {de}
}
@article{AscheBrechenmacher2022,
  author    = {Asche, Matthias and Brechenmacher, Thomas},
  title     = {Auswahlbibliographie zur berlin-brandenburgischen Immigrationsgeschichte},
  series = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  journal   = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-506-4},
  doi       = {10.25932/publishup-54689},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-546899},
  pages     = {251 -- 262},
  year      = {2022},
  language  = {de}
}
@article{PuppeLeueSommeretal.2022,
  author    = {Puppe, Daniel and Leue, Martin and Sommer, Michael and Schaller, J{\"o}rg and Kaczorek, Danuta},
  title     = {Auto-fluorescence in phytoliths},
  series = {Frontiers in Environmental Science},
  volume    = {10},
  journal   = {Frontiers in Environmental Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-665X},
  doi       = {10.3389/fenvs.2022.915947},
  pages     = {14},
  year      = {2022},
  abstract  = {The detection of auto-fluorescence in phytogenic, hydrated amorphous silica depositions (phytoliths) has been found to be a promising approach to verify if phytoliths were burnt or not, especially in archaeological contexts. However, it is unknown so far at what temperature and how auto-fluorescence is induced in phytoliths. We used fluorescence microscopy, scanning electron microscope-energy dispersive X-ray spectroscopy (SEM-EDX), and Fourier transform infrared spectroscopy to analyze auto-fluorescence in modern phytoliths extracted from plant samples or in intact leaves of winter wheat. Leaves and extracted phytoliths were heated at different temperatures up to 600 degrees C. The aims of our experiments were i) to find out what temperature is needed to induce auto-fluorescence in phytoliths, ii) to detect temperature-dependent changes in the molecular structure of phytoliths related to auto-fluorescence, and iii) to derive a mechanistic understanding of auto-fluorescence in phytoliths. We found organic compounds associated with phytoliths to cause auto-fluorescence in phytoliths treated at temperatures below approx. 400 degrees C. In phytoliths treated at higher temperatures, i.e., 450 and 600 degrees C, phytolith auto-fluorescence was mainly caused by molecular changes of phytolith silica. Based on our results we propose that auto-fluorescence in phytoliths is caused by clusterization-triggered emissions, which are caused by overlapping electron clouds forming non-conventional chromophores. In phytoliths heated at temperatures above about 400 degrees C dihydroxylation and the formation of siloxanes result in oxygen clusters that serve as non-conventional chromophores in fluorescence events. Furthermore, SEM-EDX analyses revealed that extractable phytoliths were dominated by lumen phytoliths (62\%) compared to cell wall phytoliths (38\%). Our findings might be not only relevant in archaeological phytolith-based examinations, but also for studies on the temperature-dependent release of silicon from phytoliths and the potential of long-term carbon sequestration in phytoliths.},
  language  = {en}
}
@article{DaempflingMielkeKoellneretal.2022,
  author    = {D{\"a}mpfling, Helge L. C. and Mielke, Christian and Koellner, Nicole and Lorenz, Melanie and Rogass, Christian and Altenberger, Uwe and Harlov, Daniel E. and Knoper, Michael},
  title     = {Automatic element and mineral detection in thin sections using hyperspectral transmittance imaging microscopy (HyperTIM)},
  series = {European journal of mineralogy},
  volume    = {34},
  journal   = {European journal of mineralogy},
  number    = {3},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {0935-1221},
  doi       = {10.5194/ejm-34-275-2022},
  pages     = {275 -- 284},
  year      = {2022},
  abstract  = {In this study we present a novel method for the automatic detection of minerals and elements using hyperspectral transmittance imaging microscopy measurements of complete thin sections (HyperTIM). This is accomplished by using a hyperspectral camera system that operates in the visible and near-infrared (VNIR) range with a specifically designed sample holder, scanning setup, and a microscope lens. We utilize this method on a monazite ore thin section from Steenkampskraal (South Africa), which we analyzed for the rare earth element (REE)-bearing mineral monazite ((Ce,Nd,La)PO4), with high concentrations of Nd. The transmittance analyses with the hyperspectral VNIR camera can be used to identify REE minerals and Nd in thin sections. We propose a three-point band depth index, the Nd feature depth index (NdFD), and its related product the Nd band depth index (NdBDI), which enables automatic mineral detection and classification for the Nd-bearing monazites in thin sections. In combination with the average concentration of the relative Nd content, it permits a destruction-free, total concentration calculation for Nd across the entire thin section.},
  language  = {en}
}
@article{EsmaeilishirazifardUsherTrimetal.2022,
  author    = {Esmaeilishirazifard, Elham and Usher, Louise and Trim, Carol and Denise, Hubert and Sangal, Vartul and Tyson, Gregory H. and Barlow, Axel and Redway, Keith F. and Taylor, John D. and Kremyda-Vlachou, Myrto and Davies, Sam and Loftus, Teresa D. and Lock, Mikaella M. G. and Wright, Kstir and Dalby, Andrew and Snyder, Lori A. S. and Wuster, Wolfgang and Trim, Steve and Moschos, Sterghios A.},
  title     = {Bacterial adaptation to venom in snakes and arachnida},
  series = {Microbiology spectrum},
  volume    = {10},
  journal   = {Microbiology spectrum},
  number    = {3},
  publisher = {American Society for Microbiology},
  address   = {Birmingham, Ala.},
  issn      = {2165-0497},
  doi       = {10.1128/spectrum.02408-21},
  pages     = {16},
  year      = {2022},
  abstract  = {Notwithstanding their 3 to 5\% mortality, the 2.7 million envenomation-related injuries occurring annually-predominantly across Africa, Asia, and Latin America-are also major causes of morbidity. Venom toxin-damaged tissue will develop infections in some 75\% of envenomation victims, with E. faecalis being a common culprit of disease; however, such infections are generally considered to be independent of envenomation. Animal venoms are considered sterile sources of antimicrobial compounds with strong membrane-disrupting activity against multidrug-resistant bacteria. However, venomous bite wound infections are common in developing nations. Investigating the envenomation organ and venom microbiota of five snake and two spider species, we observed venom community structures that depend on the host venomous animal species and evidenced recovery of viable microorganisms from black-necked spitting cobra (Naja nigricollis) and Indian ornamental tarantula (Poecilotheria regalis) venoms. Among the bacterial isolates recovered from N. nigricollis, we identified two venom-resistant, novel sequence types of Enterococcus faecalis whose genomes feature 16 virulence genes, indicating infectious potential, and 45 additional genes, nearly half of which improve bacterial membrane integrity. Our findings challenge the dogma of venom sterility and indicate an increased primary infection risk in the clinical management of venomous animal bite wounds. IMPORTANCE Notwithstanding their 3 to 5\% mortality, the 2.7 million envenomation-related injuries occurring annually-predominantly across Africa, Asia, and Latin America-are also major causes of morbidity. Venom toxin-damaged tissue will develop infections in some 75\% of envenomation victims, with E. faecalis being a common culprit of disease; however, such infections are generally considered to be independent of envenomation. Here, we provide evidence on venom microbiota across snakes and arachnida and report on the convergent evolution mechanisms that can facilitate adaptation to black-necked cobra venom in two independent E. faecalis strains, easily misidentified by biochemical diagnostics. Therefore, since inoculation with viable and virulence gene-harboring bacteria can occur during envenomation, acute infection risk management following envenomation is warranted, particularly for immunocompromised and malnourished victims in resource-limited settings. These results shed light on how bacteria evolve for survival in one of the most extreme environments on Earth and how venomous bites must be also treated for infections.},
  language  = {en}
}
@article{IlicicGrossart2022,
  author    = {Ilicic, Doris and Grossart, Hans-Peter},
  title     = {Basal parasitic fungi in marine food webs-a mystery yet to unravel},
  series = {Journal of Fungi},
  volume    = {8},
  journal   = {Journal of Fungi},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2309-608X},
  doi       = {10.3390/jof8020114},
  pages     = {16},
  year      = {2022},
  abstract  = {Although aquatic and parasitic fungi have been well known for more than 100 years, they have only recently received increased awareness due to their key roles in microbial food webs and biogeochemical cycles. There is growing evidence indicating that fungi inhabit a wide range of marine habitats, from the deep sea all the way to surface waters, and recent advances in molecular tools, in particular metagenome approaches, reveal that their diversity is much greater and their ecological roles more important than previously considered. Parasitism constitutes one of the most widespread ecological interactions in nature, occurring in almost all environments. Despite that, the diversity of fungal parasites, their ecological functions, and, in particular their interactions with other microorganisms remain largely speculative, unexplored and are often missing from current theoretical concepts in marine ecology and biogeochemistry. In this review, we summarize and discuss recent research avenues on parasitic fungi and their ecological potential in marine ecosystems, e.g., the fungal shunt, and emphasize the need for further research.},
  language  = {en}
}
@article{PietrekKangasKliegletal.2022,
  author    = {Pietrek, Anou F. and Kangas, Maria and Kliegl, Reinhold and Rapp, Michael A. and Heinzel, Stephan and Van der Kaap-Deeder, Jolene and Heissel, Andreas},
  title     = {Basic psychological need satisfaction and frustration in major depressive disorder},
  series = {Frontiers in Psychiatry - Mood Disorders},
  journal   = {Frontiers in Psychiatry - Mood Disorders},
  publisher = {Frontiers Media S.A.},
  address   = {Lausanne, Schweiz},
  issn      = {1664-0640},
  doi       = {10.3389/fpsyt.2022.962501},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Basic psychological needs theory postulates that a social environment that satisfies individuals' three basic psychological needs of autonomy, competence, and relatedness leads to optimal growth and well-being. On the other hand, the frustration of these needs is associated with ill-being and depressive symptoms foremost investigated in non-clinical samples; yet, there is a paucity of research on need frustration in clinical samples. Survey data were compared between adult individuals with major depressive disorder (MDD; n = 115; 48.69\% female; 38.46 years, SD = 10.46) with those of a non-depressed comparison sample (n = 201; 53.23\% female; 30.16 years, SD = 12.81). Need profiles were examined with a linear mixed model (LMM). Individuals with depression reported higher levels of frustration and lower levels of satisfaction in relation to the three basic psychological needs when compared to non-depressed adults. The difference between depressed and non-depressed groups was significantly larger for frustration than satisfaction regarding the needs for relatedness and competence. LMM correlation parameters confirmed the expected positive correlation between the three needs. This is the first study showing substantial differences in need-based experiences between depressed and non-depressed adults. The results confirm basic assumptions of the self-determination theory and have preliminary implications in tailoring therapy for depression.},
  language  = {en}
}
@article{SecklerMetzler2022,
  author    = {Seckler, Henrik and Metzler, Ralf},
  title     = {Bayesian deep learning for error estimation in the analysis of anomalous diffusion},
  series = {Nature Communnications},
  volume    = {13},
  journal   = {Nature Communnications},
  publisher = {Nature Publishing Group UK},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-022-34305-6},
  pages     = {13},
  year      = {2022},
  abstract  = {Modern single-particle-tracking techniques produce extensive time-series of diffusive motion in a wide variety of systems, from single-molecule motion in living-cells to movement ecology. The quest is to decipher the physical mechanisms encoded in the data and thus to better understand the probed systems. We here augment recently proposed machine-learning techniques for decoding anomalous-diffusion data to include an uncertainty estimate in addition to the predicted output. To avoid the Black-Box-Problem a Bayesian-Deep-Learning technique named Stochastic-Weight-Averaging-Gaussian is used to train models for both the classification of the diffusionmodel and the regression of the anomalous diffusion exponent of single-particle-trajectories. Evaluating their performance, we find that these models can achieve a wellcalibrated error estimate while maintaining high prediction accuracies. In the analysis of the output uncertainty predictions we relate these to properties of the underlying diffusion models, thus providing insights into the learning process of the machine and the relevance of the output.},
  language  = {en}
}
@article{SecklerMetzler2022,
  author    = {Seckler, Henrik and Metzler, Ralf},
  title     = {Bayesian deep learning for error estimation in the analysis of anomalous diffusion},
  series = {Nature Communications},
  volume    = {13},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature portfolio},
  address   = {Berlin},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-022-34305-6},
  pages     = {13},
  year      = {2022},
  abstract  = {Modern single-particle-tracking techniques produce extensive time-series of diffusive motion in a wide variety of systems, from single-molecule motion in living-cells to movement ecology. The quest is to decipher the physical mechanisms encoded in the data and thus to better understand the probed systems. We here augment recently proposed machine-learning techniques for decoding anomalous-diffusion data to include an uncertainty estimate in addition to the predicted output. To avoid the Black-Box-Problem a Bayesian-Deep-Learning technique named Stochastic-Weight-Averaging-Gaussian is used to train models for both the classification of the diffusion model and the regression of the anomalous diffusion exponent of single-particle-trajectories. Evaluating their performance, we find that these models can achieve a well-calibrated error estimate while maintaining high prediction accuracies. In the analysis of the output uncertainty predictions we relate these to properties of the underlying diffusion models, thus providing insights into the learning process of the machine and the relevance of the output. <br /> Diffusive motions in complex environments such as living biological cells or soft matter systems can be analyzed with single-particle-tracking approaches, where accuracy of output may vary. The authors involve a machine-learning technique for decoding anomalous-diffusion data and provide an uncertainty estimate together with predicted output.},
  language  = {en}
}
@article{daSilvaCostaHortobagyidenOtteretal.2022,
  author    = {da Silva Costa, Andreia Abud and Hortobagyi, Tibor and den Otter, Rob and Sawers, Andrew and Moraes, Renato},
  title     = {Beam width and arm position but not cognitive task affect walking balance in older adults},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Nature Research},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-10848-y},
  pages     = {10},
  year      = {2022},
  abstract  = {Detection of changes in dynamic balance could help identify older adults at fall risk. Walking on a narrow beam with its width, cognitive load, and arm position manipulated could be an alternative to current tests. Therefore, we examined additive and interactive effects of beam width, cognitive task (CT), and arm position on dynamic balance during beam walking in older adults. Twenty older adults (69 +/- 4y) walked on 6, 8, and 10-cm wide beams (2-cm high, 4-m-long), with and without CT, with three arm positions (free, crossed, akimbo). We determined cognitive errors, distance walked, step speed, root mean square (RMS) of center of mass (COM) displacement and trunk acceleration in the frontal plane. Beam width decrease progressively reduced distance walked and increased trunk acceleration RMS. Step speed decreased on the narrowest beam and with CT. Arm crossing decreased distance walked and step speed. COM displacement RMS and cognitive errors were not affected by any manipulation. In conclusion, distance walked indicated that beam width and arm position, but less so CT, affected dynamic balance, implying that beam walking has the potential to become a test of fall risk. Stability measurements suggested effective trunk adjustments to control COM position and keep dynamic balance during the task.},
  language  = {en}
}
@article{GüntherReitzKoncebovskiKlöpping2022,
  author    = {G{\"u}nther, Claudia-Susanne and Reitz-Koncebovski, Karen and Klöpping, Peter M.},
  title     = {Begegnungen mit Mathematik},
  series = {Professionalisierung in Praxisphasen : Ergebnisse der Lehrerbildungsforschung an der Universit{\"a}t Potsdam (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 2)},
  journal   = {Professionalisierung in Praxisphasen : Ergebnisse der Lehrerbildungsforschung an der Universit{\"a}t Potsdam (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 2)},
  number    = {2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-508-8},
  issn      = {2626-3556},
  doi       = {10.25932/publishup-57075},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-570755},
  pages     = {123 -- 143},
  year      = {2022},
  abstract  = {Die Reflexion der eigenen mathematischen Bildungsbiografie angehender Mathematiklehrkr{\"a}fte bietet eine bisher wenig beachtete, aber lohnende Perspektive auf ihre zuk{\"u}nftige Lehrt{\"a}tigkeit. Insbesondere bei negativen Vorerfahrungen mit Mathematik bietet die biografische Reflexion eine Gelegenheit zur Aufarbeitung. An der Universit{\"a}t Potsdam wurde deshalb f{\"u}r Studierende des Mathematiklehramts f{\"u}r die Primar- und die Sekundarstufe ein freiwilliges Angebot zur Besch{\"a}ftigung mit der mathematischen Bildungsbiografie geschaffen. Seit dem Wintersemester 2018/19 ist dieses Angebot in das Fachdidaktische Tagespraktikum integriert. Dieser Artikel stellt den theoretischen und methodischen Hintergrund des Workshops dar. Zudem werden erste Ergebnisse einer begleitenden Untersuchung unter den Workshopteilnehmenden vorgestellt.},
  language  = {de}
}
@article{ParrySchlaegelTiedemannetal.2022,
  author    = {Parry, Victor and Schl{\"a}gel, Ulrike E. and Tiedemann, Ralph and Weithoff, Guntram},
  title     = {Behavioural Responses of Defended and Undefended Prey to Their Predator},
  series = {Biology},
  volume    = {11},
  journal   = {Biology},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2079-7737},
  doi       = {10.3390/biology11081217},
  pages     = {14},
  year      = {2022},
  abstract  = {Predation is a strong species interaction causing severe harm or death to prey. Thus, prey species have evolved various defence strategies to minimize predation risk, which may be immediate (e.g., a change in behaviour) or transgenerational (morphological defence structures). We studied the behaviour of two strains of a rotiferan prey (Brachionus calyciflorus) that differ in their ability to develop morphological defences in response to their predator Asplanchna brightwellii. Using video analysis, we tested: (a) if two strains differ in their response to predator presence and predator cues when both are undefended; (b) whether defended individuals respond to live predators or their cues; and (c) if the morphological defence (large spines) per se has an effect on the swimming behaviour. We found a clear increase in swimming speed for both undefended strains in predator presence. However, the defended specimens responded neither to the predator presence nor to their cues, showing that they behave indifferently to their predator when they are defended. We did not detect an effect of the spines on the swimming behaviour. Our study demonstrates a complex plastic behaviour of the prey, not only in the presence of their predator, but also with respect to their defence status.},
  language  = {en}
}
@article{ParrySchlaegelTiedemannetal.2022,
  author    = {Parry, Victor and Schl{\"a}gel, Ulrike E. and Tiedemann, Ralph and Weithoff, Guntram},
  title     = {Behavioural responses of defended and undefended prey to their predator},
  series = {Biology : open access journal},
  volume    = {11},
  journal   = {Biology : open access journal},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-7737},
  doi       = {10.3390/biology11081217},
  pages     = {14},
  year      = {2022},
  abstract  = {Many animals that have to cope with predation have evolved mechanisms to reduce their predation risk. One of these mechanisms is change in morphology, for example, the development of spines. These spines are induced, when mothers receive chemical signals of a predator (kairomones) and their daughters are then equipped with defensive spines. We studied the behaviour of a prey and its predator when the prey is either defended or undefended. We used common aquatic micro-invertebrates, the rotifers Brachionus calyciflorus (prey) and Asplanchna brightwellii (predator) as experimental animals. We found that undefended prey increased its swimming speed in the presence of the predator. The striking result was that the defended prey did not respond to the predator's presence. This suggests that defended prey has a different response behaviour to a predator than undefended conspecifics. Our study provides further insights into complex zooplankton predator-prey interactions. Predation is a strong species interaction causing severe harm or death to prey. Thus, prey species have evolved various defence strategies to minimize predation risk, which may be immediate (e.g., a change in behaviour) or transgenerational (morphological defence structures). We studied the behaviour of two strains of a rotiferan prey (Brachionus calyciflorus) that differ in their ability to develop morphological defences in response to their predator Asplanchna brightwellii. Using video analysis, we tested: (a) if two strains differ in their response to predator presence and predator cues when both are undefended; (b) whether defended individuals respond to live predators or their cues; and (c) if the morphological defence (large spines) per se has an effect on the swimming behaviour. We found a clear increase in swimming speed for both undefended strains in predator presence. However, the defended specimens responded neither to the predator presence nor to their cues, showing that they behave indifferently to their predator when they are defended. We did not detect an effect of the spines on the swimming behaviour. Our study demonstrates a complex plastic behaviour of the prey, not only in the presence of their predator, but also with respect to their defence status.},
  language  = {en}
}
@article{Bahl2022,
  author    = {Bahl, Peter},
  title     = {Belastung und Bereicherung - Vertriebene in Brandenburg ab 1945},
  series = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  journal   = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-506-4},
  doi       = {10.25932/publishup-54686},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-546864},
  pages     = {209 -- 223},
  year      = {2022},
  language  = {de}
}
@article{EscalanteDominguezGomezRuizetal.2022,
  author    = {Escalante, Ignacio and Dominguez, Marisol and Gomez-Ruiz, Daisy Alejandra and Machado, Glauco},
  title     = {Benefits and costs of mixed-species aggregations in Harvestmen (Arachnida: Opiliones)},
  series = {Frontiers in ecology and evolution},
  volume    = {9},
  journal   = {Frontiers in ecology and evolution},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-701X},
  doi       = {10.3389/fevo.2021.766323},
  pages     = {24},
  year      = {2022},
  abstract  = {Many animals form aggregations with individuals of the same species (single-species aggregations, SSA). Less frequently, individuals may also aggregate with individuals of other species (mixed-species aggregations, MSA). Although the benefits and costs of SSA have been intensively studied, the same is not true for MSA. Here, we first review the cases of MSA in harvestmen, an arachnid order in which the records of MSA are more frequent than other arthropod orders. We then propose several benefits and costs of MSA in harvestmen, and contrast them with those of SSA. Second, using field-gathered data we describe gregariousness in seven species of Prionostemma harvestmen from Costa Rica. These species form MSA, but individuals are also found solitarily or in SSA. We tested one possible benefit and one possible cost of gregariousness in Prionostemma harvestmen. Regarding the benefit, we hypothesized that individuals missing legs would be more exposed to predation than eight-legged individuals and thus they should be found preferentially in aggregations, where they would be more protected from predators. Our data, however, do not support this hypothesis. Regarding the cost, we hypothesized that gregariousness increases the chances of parasitism. We found no support for this hypothesis either because both mite prevalence and infestation intensity did not differ between solitary or aggregated individuals. Additionally, the type of aggregation (SSA or MSA) was not associated with the benefit or the cost we explored. This lack of effect may be explained by the fluid membership of the aggregations, as we found high turnover over time in the number of individuals and species composition of the aggregations. In conclusion, we hope our review and empirical data stimulate further studies on MSA, which remains one of the most elusive forms of group living in animals.},
  language  = {en}
}
@article{GerickeSoemerSchiefele2022,
  author    = {Gericke, Christian and Soemer, Alexander and Schiefele, Ulrich},
  title     = {Benefits of Mind Wandering for Learning in School Through Its Positive Effects on Creativity},
  series = {Frontiers in Education},
  volume    = {7},
  journal   = {Frontiers in Education},
  publisher = {Frontiers Media SA},
  address   = {Lausanne, Schweiz},
  issn      = {2504-284X},
  doi       = {10.3389/feduc.2022.774731},
  pages     = {11},
  year      = {2022},
  abstract  = {There is broad agreement among researchers to view mind wandering as an obstacle to learning because it draws attention away from learning tasks. Accordingly, empirical findings revealed negative correlations between the frequency of mind wandering during learning and various kinds of learning outcomes (e.g., text retention). However, a few studies have indicated positive effects of mind wandering on creativity in real-world learning environments. The present article reviews these studies and highlights potential benefits of mind wandering for learning mediated through creative processes. Furthermore, we propose various ways to promote useful mind wandering and, at the same time, minimize its negative impact on learning.},
  language  = {en}
}
@article{YangKimTuomainenetal.2022,
  author    = {Yang, Jingdan and Kim, Jae-Hyun and Tuomainen, Outi and Rattanasone, Nan Xu},
  title     = {Bilingual Mandarin-English preschoolers' spoken narrative skills and contributing factors},
  series = {Frontiers in Psyhology},
  volume    = {13},
  journal   = {Frontiers in Psyhology},
  publisher = {Frontiers Media SA},
  address   = {Lausanne, Schweiz},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2022.797602},
  pages     = {12},
  year      = {2022},
  abstract  = {This study examined the spoken narrative skills of a group of bilingual Mandarin-English speaking 3-6-year-olds (N = 25) in Australia, using a remote online story-retell task. Bilingual preschoolers are an understudied population, especially those who are speaking typologically distinct languages such as Mandarin and English which have fewer structural overlaps compared to language pairs that are typologically closer, reducing cross-linguistic positive transfer. We examined these preschoolers' spoken narrative skills as measured by macrostructures (the global organization of a story) and microstructures (linguistic structures, e.g., total number of utterances, nouns, verbs, phrases, and modifiers) across and within each language, and how various factors such as age and language experiences contribute to individual variability. The results indicate that our bilingual preschoolers acquired spoken narrative skills similarly across their two languages, i.e., showing similar patterns of productivity for macrostructure and microstructure elements in both of their two languages. While chronological age was positively correlated with macrostructures in both languages (showing developmental effects), there were no significant correlations between measures of language experiences and the measures of spoken narrative skills (no effects for language input/output). The findings suggest that although these preschoolers acquire two typologically diverse languages in different learning environments, Mandarin at home with highly educated parents, and English at preschool, they displayed similar levels of oral narrative skills as far as these macro-/micro-structure measures are concerned. This study provides further evidence for the feasibility of remote online assessment of preschoolers' narrative skills.},
  language  = {en}
}
@article{NagakuraSchubertWagneretal.2022,
  author    = {Nagakura, Toshiki and Schubert, Florian and Wagner, Dirk and Kallmeyer, Jens},
  title     = {Biological sulfate reduction in deep subseafloor sediment of Guaymas Basin},
  series = {Frontiers in microbiology},
  volume    = {13},
  journal   = {Frontiers in microbiology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  organization    = {IODP Exp 385 Shipboard Sci Party},
  issn      = {1664-302X},
  doi       = {10.3389/fmicb.2022.845250},
  pages     = {12},
  year      = {2022},
  abstract  = {Sulfate reduction is the quantitatively most important process to degrade organic matter in anoxic marine sediment and has been studied intensively in a variety of settings. Guaymas Basin, a young marginal ocean basin, offers the unique opportunity to study sulfate reduction in an environment characterized by organic-rich sediment, high sedimentation rates, and high geothermal gradients (100-958 degrees C km(-1)). We measured sulfate reduction rates (SRR) in samples taken during the International Ocean Discovery Program (IODP) Expedition 385 using incubation experiments with radiolabeled (SO42-)-S-35 carried out at in situ pressure and temperature. The highest SRR (387 nmol cm(-3) d(-1)) was recorded in near-surface sediments from Site U1548C, which had the steepest geothermal gradient (958 degrees C km(-1)). At this site, SRR were generally over an order of magnitude higher than at similar depths at other sites (e.g., 387-157 nmol cm(-3) d(-1) at 1.9 mbsf from Site U1548C vs. 46-1.0 nmol cm(-3) d(-1) at 2.1 mbsf from Site U1552B). Site U1546D is characterized by a sill intrusion, but it had already reached thermal equilibrium and SRR were in the same range as nearby Site U1545C, which is minimally affected by sills. The wide temperature range observed at each drill site suggests major shifts in microbial community composition with very different temperature optima but awaits confirmation by molecular biological analyses. At the transition between the mesophilic and thermophilic range around 40 degrees C-60 degrees C, sulfate-reducing activity appears to be decreased, particularly in more oligotrophic settings, but shows a slight recovery at higher temperatures.},
  language  = {en}
}
@article{LehmannKuhnKelleretal.2022,
  author    = {Lehmann, Nico and Kuhn, Yves-Alain and Keller, Martin and Aye, Norman and Herold, Fabian and Draganski, Bogdan and Taube, Wolfgang and Taubert, Marco},
  title     = {Brain activation during active balancing and its behavioral relevance in younger and older adults},
  series = {Frontiers in Aging Neuroscience},
  volume    = {14},
  journal   = {Frontiers in Aging Neuroscience},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1663-4365},
  doi       = {10.3389/fnagi.2022.828474},
  pages     = {20},
  year      = {2022},
  abstract  = {Age-related deterioration of balance control is widely regarded as an important phenomenon influencing quality of life and longevity, such that a more comprehensive understanding of the neural mechanisms underlying this process is warranted. Specifically, previous studies have reported that older adults typically show higher neural activity during balancing as compared to younger counterparts, but the implications of this finding on balance performance remain largely unclear. Using functional near-infrared spectroscopy (fNIRS), differences in the cortical control of balance between healthy younger (n = 27) and older (n = 35) adults were explored. More specifically, the association between cortical functional activity and balance performance across and within age groups was investigated. To this end, we measured hemodynamic responses (i.e., changes in oxygenated and deoxygenated hemoglobin) while participants balanced on an unstable device. As criterion variables for brain-behavior-correlations, we also assessed postural sway while standing on a free-swinging platform and while balancing on wobble boards with different levels of difficulty. We found that older compared to younger participants had higher activity in prefrontal and lower activity in postcentral regions. Subsequent robust regression analyses revealed that lower prefrontal brain activity was related to improved balance performance across age groups, indicating that higher activity of the prefrontal cortex during balancing reflects neural inefficiency. We also present evidence supporting that age serves as a moderator in the relationship between brain activity and balance, i.e., cortical hemodynamics generally appears to be a more important predictor of balance performance in the older than in the younger. Strikingly, we found that age differences in balance performance are mediated by balancing-induced activation of the superior frontal gyrus, thus suggesting that differential activation of this region reflects a mechanism involved in the aging process of the neural control of balance. Our study suggests that differences in functional brain activity between age groups are not a mere by-product of aging, but instead of direct behavioral relevance for balance performance. Potential implications of these findings in terms of early detection of fall-prone individuals and intervention strategies targeting balance and healthy aging are discussed.},
  language  = {en}
}
@article{AscheBrechenmacher2022,
  author    = {Asche, Matthias and Brechenmacher, Thomas},
  title     = {Brandenburg und die Migration - thematische Einf{\"u}hrung und chronologische {\"U}bersicht},
  series = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  journal   = {Hier geblieben? Brandenburg als Einwanderungsland vom Mittelalter bis heute},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-506-4},
  doi       = {10.25932/publishup-54651},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-546516},
  pages     = {11 -- 34},
  year      = {2022},
  language  = {de}
}
@article{IrobBlaumBaldaufetal.2022,
  author    = {Irob, Katja and Blaum, Niels and Baldauf, Selina and Kerger, Leon and Strohbach, Ben and Kanduvarisa, Angelina and Lohmann, Dirk and Tietjen, Britta},
  title     = {Browsing herbivores improve the state and functioning of savannas},
  series = {Ecology and evolution},
  volume    = {12},
  journal   = {Ecology and evolution},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.8715},
  pages     = {19},
  year      = {2022},
  abstract  = {Changing climatic conditions and unsustainable land use are major threats to savannas worldwide. Historically, many African savannas were used intensively for livestock grazing, which contributed to widespread patterns of bush encroachment across savanna systems. To reverse bush encroachment, it has been proposed to change the cattle-dominated land use to one dominated by comparatively specialized browsers and usually native herbivores. However, the consequences for ecosystem properties and processes remain largely unclear. We used the ecohydrological, spatially explicit model EcoHyD to assess the impacts of two contrasting, herbivore land-use strategies on a Namibian savanna: grazer- versus browser-dominated herbivore communities. We varied the densities of grazers and browsers and determined the resulting composition and diversity of the plant community, total vegetation cover, soil moisture, and water use by plants. Our results showed that plant types that are less palatable to herbivores were best adapted to grazing or browsing animals in all simulated densities. Also, plant types that had a competitive advantage under limited water availability were among the dominant ones irrespective of land-use scenario. Overall, the results were in line with our expectations: under high grazer densities, we found heavy bush encroachment and the loss of the perennial grass matrix. Importantly, regardless of the density of browsers, grass cover and plant functional diversity were significantly higher in browsing scenarios. Browsing herbivores increased grass cover, and the higher total cover in turn improved water uptake by plants overall. We concluded that, in contrast to grazing-dominated land-use strategies, land-use strategies dominated by browsing herbivores, even at high herbivore densities, sustain diverse vegetation communities with high cover of perennial grasses, resulting in lower erosion risk and bolstering ecosystem services.},
  language  = {en}
}
@article{BarcenaAslamPozdniakovaetal.2022,
  author    = {Barcena, Maria Luisa and Aslam, Muhammad and Pozdniakova, Sofya and Norman, Kristina and Ladilov, Yury},
  title     = {Cardiovascular inflammaging: mechanisms and translational aspects},
  series = {Cells},
  volume    = {11},
  journal   = {Cells},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4409},
  doi       = {10.3390/cells11061010},
  pages     = {15},
  year      = {2022},
  abstract  = {Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.},
  language  = {en}
}
@article{SchaeferBittmann2022,
  author    = {Schaefer, Laura and Bittmann, Frank},
  title     = {Case Study: Intra- and Interpersonal Coherence of Muscle and Brain Activity of Two Coupled Persons during Pushing and Holding Isometric Muscle Action},
  series = {Brain Sciences},
  volume    = {12},
  journal   = {Brain Sciences},
  edition   = {6},
  publisher = {MDPI Open Access Publishing},
  address   = {Basel, Schweiz},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci12060703},
  pages     = {27},
  year      = {2022},
  abstract  = {Inter-brain synchronization is primarily investigated during social interactions but had not been examined during coupled muscle action between two persons until now. It was previously shown that mechanical muscle oscillations can develop coherent behavior between two isometrically interacting persons. This case study investigated if inter-brain synchronization appears thereby, and if differences of inter- and intrapersonal muscle and brain coherence exist regarding two different types of isometric muscle action. Electroencephalography (EEG) and mechanomyography/mechanotendography (MMG/MTG) of right elbow extensors were recorded during six fatiguing trials of two coupled isometrically interacting participants (70\% MVIC). One partner performed holding and one pushing isometric muscle action (HIMA/PIMA; tasks changed). The wavelet coherence of all signals (EEG, MMG/MTG, force, ACC) were analyzed intra- and interpersonally. The five longest coherence patches in 8-15 Hz and their weighted frequency were compared between real vs. random pairs and between HIMA vs. PIMA. Real vs. random pairs showed significantly higher coherence for intra-muscle, intra-brain, and inter-muscle-brain activity (p < 0.001 to 0.019). Inter-brain coherence was significantly higher for real vs. random pairs for EEG of right and central areas and for sub-regions of EEG left (p = 0.002 to 0.025). Interpersonal muscle-brain synchronization was significantly higher than intrapersonal one, whereby it was significantly higher for HIMA vs. PIMA. These preliminary findings indicate that inter-brain synchronization can arise during muscular interaction. It is hypothesized both partners merge into one oscillating neuromuscular system. The results reinforce the hypothesis that HIMA is characterized by more complex control strategies than PIMA. The pilot study suggests investigating the topic further to verify these results on a larger sample size. Findings could contribute to the basic understanding of motor control and is relevant for functional diagnostics such as the manual muscle test which is applied in several disciplines, e.g., neurology, physiotherapy.},
  language  = {en}
}
@article{Miklashevsky2022,
  author    = {Miklashevsky, Alex},
  title     = {Catch the star! Spatial information activates the manual motor system},
  series = {PLoS ONE},
  journal   = {PLoS ONE},
  publisher = {PLOS},
  address   = {San Francisco, California, US},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0262510},
  pages     = {1 -- 30},
  year      = {2022},
  abstract  = {Previous research demonstrated a close bidirectional relationship between spatial attention and the manual motor system. However, it is unclear whether an explicit hand movement is necessary for this relationship to appear. A novel method with high temporal resolution-bimanual grip force registration-sheds light on this issue. Participants held two grip force sensors while being presented with lateralized stimuli (exogenous attentional shifts, Experiment 1), left- or right-pointing central arrows (endogenous attentional shifts, Experiment 2), or the words "left" or "right" (endogenous attentional shifts, Experiment 3). There was an early interaction between the presentation side or arrow direction and grip force: lateralized objects and central arrows led to a larger increase of the ipsilateral force and a smaller increase of the contralateral force. Surprisingly, words led to the opposite pattern: larger force increase in the contralateral hand and smaller force increase in the ipsilateral hand. The effect was stronger and appeared earlier for lateralized objects (60 ms after stimulus presentation) than for arrows (100 ms) or words (250 ms). Thus, processing visuospatial information automatically activates the manual motor system, but the timing and direction of this effect vary depending on the type of stimulus.},
  language  = {en}
}
@article{SchlosshauerCavakZemellaetal.2022,
  author    = {Schloßhauer, Jeffrey and Cavak, Ni{\~n}o and Zemella, Anne and Thoring, Lena and Kubick, Stefan},
  title     = {Cell engineering and cultivation of chinese hamster ovary cells for the development of orthogonal eukaryotic cell-free translation systems},
  series = {Frontiers in molecular biosciences},
  volume    = {9},
  journal   = {Frontiers in molecular biosciences},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-889X},
  doi       = {10.3389/fmolb.2022.832379},
  pages     = {13},
  year      = {2022},
  abstract  = {The investigation of protein structures, functions and interactions often requires modifications to adapt protein properties to the specific application. Among many possible methods to equip proteins with new chemical groups, the utilization of orthogonal aminoacyl-tRNA synthetase/tRNA pairs enables the site-specific incorporation of non-canonical amino acids at defined positions in the protein. The open nature of cell-free protein synthesis reactions provides an optimal environment, as the orthogonal components do not need to be transported across the cell membrane and the impact on cell viability is negligible. In the present work, it was shown that the expression of orthogonal aminoacyl-tRNA synthetases in CHO cells prior to cell disruption enhanced the modification of the pharmaceutically relevant adenosine A2a receptor. For this purpose, in complement to transient transfection of CHO cells, an approach based on CRISPR/Cas9 technology was selected to generate a translationally active cell lysate harboring endogenous orthogonal aminoacyl-tRNA synthetase.},
  language  = {en}
}
@article{RammJackKaseretal.2022,
  author    = {Ramm, Franziska and Jack, Lena and Kaser, Danny and Schloßhauer, Jeffrey L. and Zemella, Anne and Kubick, Stefan},
  title     = {Cell-Free Systems Enable the Production of AB(5) Toxins for Diagnostic Applications},
  series = {Toxins},
  volume    = {14},
  journal   = {Toxins},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6651},
  doi       = {10.3390/toxins14040233},
  pages     = {19},
  year      = {2022},
  abstract  = {Cell-free protein synthesis (CFPS) represents a versatile key technology for the production of toxic proteins. As a cell lysate, rather than viable cells, is used, the toxic effects on the host organism can be circumvented. The open nature of cell-free systems allows for the addition of supplements affecting protein concentration and folding. Here, we present the cell-free synthesis and functional characterization of two AB(5) toxins, namely the cholera toxin (Ctx) and the heat-labile enterotoxin (LT), using two eukaryotic cell-free systems based on Chinese hamster ovary (CHO) and Spodoptera frugiperda (Sf21) cells. Through an iterative optimization procedure, the synthesis of the individual AB(5) toxins was established, and the formation of multimeric structures could be shown by autoradiography. A functional analysis was performed using cell-based assays, thereby demonstrating that the LT complex induced the characteristic cell elongation of target cells after 24 h. The LT complex induced cell death at higher concentrations, starting at an initial concentration of 5 nM. The initial toxic effects of the Ctx multimer could already be detected at 4 nM. The detection and characterization of such AB(5) toxins is of utmost importance, and the monitoring of intracellular trafficking facilitates the further identification of the mechanism of action of these toxins. We showed that the B-subunit of LT (LTB) could be fluorescently labeled using an LTB-Strep fusion protein, which is a proof-of-concept for future Trojan horse applications. Further, we performed a mutational analysis of the CtxA subunit as its template was modified, and an amber stop codon was inserted into CtxA's active site. Subsequently, a non-canonical amino acid was site-specifically incorporated using bio-orthogonal systems. Finally, a fluorescently labeled CtxA protein was produced using copper-catalyzed click reactions as well as a Staudinger ligation. As expected, the modified Ctx multimer no longer induced toxic effects. In our study, we showed that CFPS could be used to study the active centers of toxins by inserting mutations. Additionally, this methodology can be applied for the design of Trojan horses and targeted toxins, as well as enabling the intracellular trafficking of toxins as a prerequisite for the analysis of the toxin's mechanism of action.},
  language  = {en}
}
@article{KretzschmarAshbyFearonetal.2022,
  author    = {Kretzschmar, Mirjam E. and Ashby, Ben and Fearon, Elizabeth and Overton, Christopher E. and Panovska-Griffiths, Jasmina and Pellis, Lorenzo and Quaife, Matthew and Rozhnova, Ganna and Scarabel, Francesca and Stage, Helena B. and Swallow, Ben and Thompson, Robin N. and Tildesley, Michael J. and Villela, Daniel Campos},
  title     = {Challenges for modelling interventions for future pandemics},
  series = {Epidemics},
  volume    = {38},
  journal   = {Epidemics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1755-4365},
  doi       = {10.1016/j.epidem.2022.100546},
  pages     = {13},
  year      = {2022},
  abstract  = {Mathematical modelling and statistical inference provide a framework to evaluate different non-pharmaceutical and pharmaceutical interventions for the control of epidemics that has been widely used during the COVID-19 pandemic. In this paper, lessons learned from this and previous epidemics are used to highlight the challenges for future pandemic control. We consider the availability and use of data, as well as the need for correct parameterisation and calibration for different model frameworks. We discuss challenges that arise in describing and distinguishing between different interventions, within different modelling structures, and allowing both within and between host dynamics. We also highlight challenges in modelling the health economic and political aspects of interventions. Given the diversity of these challenges, a broad variety of interdisciplinary expertise is needed to address them, combining mathematical knowledge with biological and social insights, and including health economics and communication skills. Addressing these challenges for the future requires strong cross disciplinary collaboration together with close communication between scientists and policy makers.},
  language  = {en}
}
@masterthesis{Koenig2022,
  type      = {Bachelor Thesis},
  author    = {K{\"o}nig, Alexander},
  title     = {Change-Prozesse in der {\"o}ffentlichen Verwaltung - Der Einfluss von direkten Vorgesetzten auf die Einstellung von Mitarbeitenden},
  issn      = {2190-4561},
  doi       = {10.25932/publishup-56571},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565713},
  school      = {Universit{\"a}t Potsdam},
  pages     = {IV, 35},
  year      = {2022},
  abstract  = {Die {\"o}ffentliche Verwaltung wird in den n{\"a}chsten Jahrzehnten große Reformen durchlaufen m{\"u}ssen. Ein wichtiger Einflussfaktor f{\"u}r das Gelingen von geplanten organisatorischen Ver{\"a}nderungen ist auch im Verwaltungskontext die Einstellung von Mitarbeiter*innen gegen{\"u}ber diesem Wandel. Hier existieren gerade bei Mitarbeiter*innen ohne F{\"u}hrungsverantwortlichkeit h{\"a}ufig negative Einstellungen gegen{\"u}ber Ver{\"a}nderungen. Dies wird auch mit dem hohen Stress in diesen Situationen in Verbindung gebracht. Besonders direkte F{\"u}hrungskr{\"a}fte sind hier eine wichtige Einflussgr{\"o}ße auf die Einstellungen. Die folgende Bachelorarbeit besch{\"a}ftigt sich dementsprechend mit diesen Einfluss und konzentriert sich dabei auf den Effekt der sozialen Unterst{\"u}tzung dieser F{\"u}hrungskr{\"a}fte auf die Einstellung der Mitarbeiter*innen, da soziale Unterst{\"u}tzung einen nachgewiesenen mildernden Effekt auf den wahrgenommenen Stress besitzt. Soziale Unterst{\"u}tzung wird nach der Social-Support-Theorie in die dort identifizierten vier Unter-arten differenziert, namentlich Appraisal, Emotional, Informational und Instrumental Support. Im Rahmen einer Literaturanalyse konnte f{\"u}r zwei der vier Supportarten (Emotional, Informational) ein Einfluss nachgewiesen werden. Auch f{\"u}r die anderen Supportarten bestehen Hinweise auf einen positiven Effekt. Dies weist darauf hin, dass direkte F{\"u}hrungskr{\"a}fte w{\"a}hrend Reformen der {\"o}ffentlichen Verwaltung als Quellen der Unterst{\"u}tzung fungieren und mittels dieser die Einstellung der Mitarbeiter*innen gegen{\"u}ber Wandel positiv beeinflussen. Dar{\"u}ber hinaus k{\"o}nnen die Unterschiede der Ergebnisse nach Supportart darauf hinweisen, dass situationsspezifisch ver-schiedene Unterst{\"u}tzung mehr oder weniger relevant ist. F{\"u}r F{\"u}hrungskr{\"a}fte in diesem Kontext verweisen die Ergebnisse der Arbeit darauf, dass der unterst{\"u}tzende Kontakt mit direkt Untergebenen in Phasen des Wandels wichtig und die Anforderungen breiter als die reine Anweisung dieser Untergebenen sind.},
  language  = {de}
}
@article{KruseAltattanLauxetal.2022,
  author    = {Kruse, Marlen and Altattan, Basma and Laux, Eva-Maria and Grasse, Nico and Heinig, Lars and M{\"o}ser, Christin and Smith, David M. and H{\"o}lzel, Ralph},
  title     = {Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-16914-9},
  pages     = {12},
  year      = {2022},
  abstract  = {Binding interactions of the spike proteins of the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) to a peptide fragment derived from the human angiotensin converting enzyme 2 (hACE2) receptor are investigated. The peptide is employed as capture moiety in enzyme linked immunosorbent assays (ELISA) and quantitative binding interaction measurements that are based on fluorescence proximity sensing (switchSENSE). In both techniques, the peptide is presented on an oligovalent DNA nanostructure, in order to assess the impact of mono- versus trivalent binding modes. As the analyte, the spike protein and several of its subunits are tested as well as inactivated SARS-CoV-2 and pseudo viruses. While binding of the peptide to the full-length spike protein can be observed, the subunits RBD and S1 do not exhibit binding in the employed concentrations. Variations of the amino acid sequence of the recombinant full-length spike proteins furthermore influence binding behavior. The peptide was coupled to DNA nanostructures that form a geometric complement to the trimeric structure of the spike protein binding sites. An increase in binding strength for trimeric peptide presentation compared to single peptide presentation could be generally observed in ELISA and was quantified in switchSENSE measurements. Binding to inactivated wild type viruses could be shown as well as qualitatively different binding behavior of the Alpha and Beta variants compared to the wild type virus strain in pseudo virus models.},
  language  = {en}
}
@article{WelkeSperberBergmannetal.2022,
  author    = {Welke, Robert-William and Sperber, Hannah Sabeth and Bergmann, Ronny and Koikkarah, Amit and Menke, Laura and Sieben, Christian and Kr{\"u}ger, Detlev H. and Chiantia, Salvatore and Herrmann, Andreas and Schwarzer, Roland},
  title     = {Characterization of hantavirus N protein intracellular dynamics and localization},
  series = {Viruses},
  volume    = {14},
  journal   = {Viruses},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1999-4915},
  doi       = {10.3390/v14030457},
  pages     = {14},
  year      = {2022},
  abstract  = {Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome. The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation, and several other crucial processes during hantavirus infection. In this study, we generated fluorescently tagged N protein constructs derived from Puumalavirus (PUUV), the dominant hantavirus species in Central, Northern, and Eastern Europe. We comprehensively characterized this protein in the rodent cell line CHO-K1, monitoring the dynamics of N protein complex formation and investigating co-localization with host proteins as well as the viral glycoproteins Gc and Gn. We observed formation of large, fibrillar PUUV N protein aggregates, rapidly coalescing from early punctate and spike-like assemblies. Moreover, we found significant spatial correlation of N with vimentin, actin, and P-bodies but not with microtubules. N constructs also co-localized with Gn and Gc albeit not as strongly as the glycoproteins associated with each other. Finally, we assessed oligomerization of N constructs, observing efficient and concentration-dependent multimerization, with complexes comprising more than 10 individual proteins.},
  language  = {en}
}
@article{MoradianRochAnthoferetal.2022,
  author    = {Moradian, Hanieh and Roch, Toralf and Anthofer, Larissa and Lendlein, Andreas and Gossen, Manfred},
  title     = {Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages},
  series = {Molecular therapy},
  volume    = {27},
  journal   = {Molecular therapy},
  publisher = {Cell Press},
  address   = {Cambridge},
  issn      = {2162-2531},
  doi       = {10.1016/j.omtn.2022.01.004},
  pages     = {854 -- 869},
  year      = {2022},
  abstract  = {In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines. Robust expression levels, lack of genotoxicity, and their manageable immunogenicity benefit its clinical applicability. We postulated that innate immune responses of therapeutically relevant human cells can be tailored or abrogated by combinations of 5'-end and internal IVT-mRNA modifications. Using primary human macrophages as targets, our data show the particular importance of uridine modifications for IVT-mRNA performance. Among five nucleotide modification schemes tested, 5-methoxy-uridine outperformed other modifications up to 4-fold increased transgene expression, triggering moderate proinflammatory and non-detectable antiviral responses. Macrophage responses against IVT-mRNAs exhibiting high immunogenicity (e.g., pseudouridine) could be minimized upon HPLC purification. Conversely, 5'-end modifications had only modest effects on mRNA expression and immune responses. Our results revealed how the uptake of chemically modified IVT-mRNA impacts human macrophages, responding with distinct patterns of innate immune responses concomitant with increased transient transgene expression. We anticipate our findings are instrumental to predictively address specific cell responses required for a wide range of therapeutic applications from eliciting controlled immunogenicity in mRNA vaccines to, e.g., completely abrogating cell activation in protein replacement therapies.},
  language  = {en}
}
@article{LindnerMoellerDresenetal.2022,
  author    = {Lindner, Nadja and Moeller, Korbinian and Dresen, Verena and Pixner, Silvia and Lonnemann, Jan},
  title     = {Children's spatial language skills predict their verbal number skills},
  series = {PLOS ONE},
  volume    = {17},
  journal   = {PLOS ONE},
  number    = {10},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0277026},
  pages     = {15},
  year      = {2022},
  abstract  = {The process of number symbolization is assumed to be critically influenced by the acquisition of so-called verbal number skills (e.g., verbally reciting the number chain and naming Arabic numerals). For the acquisition of these verbal number skills, verbal and visuospatial skills are discussed as contributing factors. In this context, children's verbal number skills have been found to be associated with their concurrent spatial language skills such as mastery of verbal descriptions of spatial position (e.g., in front of, behind). In a longitudinal study with three measurement times (T1, T2, T3) at an interval of about 6 months, we evaluated the predictive role of preschool children's (mean age at T1: 3 years and 10 months) spatial language skills for the acquisition of verbal number skills. Children's spatial language skills at T2 significantly predicted their verbal number skills at T3, when controlling for influences of important covariates such as vocabulary knowledge. In addition, further analyses replicated previous results indicating that children's spatial language skills at T2 were associated with their verbal number skills at T2. Exploratory analyses further revealed that children's verbal number skills at T1 predict their spatial language at T2. Results suggests that better spatial language skills at the age of 4 years facilitate the future acquisition of verbal number skills.},
  language  = {en}
}
@article{LindnerMoellerHildebrandtetal.2022,
  author    = {Lindner, Nadja and Moeller, Korbinian and Hildebrandt, Frauke and Hasselhorn, Marcus and Lonnemann, Jan},
  title     = {Children's use of egocentric reference frames in spatial language is related to their numerical magnitude understanding},
  series = {Frontiers in Psychology},
  journal   = {Frontiers in Psychology},
  publisher = {Frontiers},
  address   = {Lausanne, Schweiz},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2022.943191},
  pages     = {1 -- 13},
  year      = {2022},
  abstract  = {Numerical magnitude information is assumed to be spatially represented in the form of a mental number line defined with respect to a body-centred, egocentric frame of reference. In this context, spatial language skills such as mastery of verbal descriptions of spatial position (e.g., in front of, behind, to the right/left) have been proposed to be relevant for grasping spatial relations between numerical magnitudes on the mental number line. We examined 4- to 5-year-old's spatial language skills in tasks that allow responses in egocentric and allocentric frames of reference, as well as their relative understanding of numerical magnitude (assessed by a number word comparison task). In addition, we evaluated influences of children's absolute understanding of numerical magnitude assessed by their number word comprehension (montring different numbers using their fingers) and of their knowledge on numerical sequences (determining predecessors and successors as well as identifying missing dice patterns of a series). Results indicated that when considering responses that corresponded to the egocentric perspective, children's spatial language was associated significantly with their relative numerical magnitude understanding, even after controlling for covariates, such as children's SES, mental rotation skills, and also absolute magnitude understanding or knowledge on numerical sequences. This suggests that the use of egocentric reference frames in spatial language may facilitate spatial representation of numbers along a mental number line and thus seem important for preschoolers' relative understanding of numerical magnitude.},
  language  = {en}
}
@article{RamachandranRupakhetiCherianetal.2022,
  author    = {Ramachandran, Srikanthan and Rupakheti, Maheswar and Cherian, R. and Lawrence, Mark},
  title     = {Climate Benefits of Cleaner Energy Transitions in East and South Asia Through Black Carbon Reduction},
  series = {Frontiers in environmental science},
  volume    = {10},
  journal   = {Frontiers in environmental science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-665X},
  doi       = {10.3389/fenvs.2022.842319},
  pages     = {16},
  year      = {2022},
  abstract  = {The state of air pollution has historically been tightly linked to how we produce and use energy. Air pollutant emissions over Asia are now changing rapidly due to cleaner energy transitions; however, magnitudes of benefits for climate and air quality remain poorly quantified. The associated risks involve adverse health impacts, reduced agricultural yields, reduced freshwater availability, contributions to climate change, and economic costs. We focus particularly on climate benefits of energy transitions by making first-time use of two decades of high quality observations of atmospheric loading of light-absorbing black carbon (BC) over Kanpur (South Asia) and Beijing (East Asia) and relating these observations to changing energy, emissions, and economic trends in India and China. Our analysis reveals that absorption aerosol optical depth (AAOD) due to BC has decreased substantially, by 40\% over Kanpur and 60\% over Beijing between 2001 and 2017, and thus became decoupled from regional economic growth. Furthermore, the resultant decrease in BC emissions and BC AAOD over Asia is regionally coherent and occurs primarily due to transitions into cleaner energies (both renewables and fossil fuels) and not due to the decrease in primary energy supply or decrease in use of fossil use and biofuels and waste. Model simulations show that BC aerosols alone contribute about half of the surface temperature change (warming) of the total forcing due to greenhouse gases, natural and internal variability, and aerosols, thus clearly revealing the climate benefits due to a reduction in BC emissions, which would significantly reduce global warming. However, this modeling study excludes responses from natural variability, circulation, and sea ice responses, which cause relatively strong temperature fluctuations that may mask signals from BC aerosols. Our findings show additional benefits for climate (beyond benefits of CO2 reduction) and for several other issues of sustainability over South and East Asia, provide motivation for ongoing cleaner energy production, and consumption transitions, especially when they are associated with reduced emissions of air pollutants. Such an analysis connecting the trends in energy transitions and aerosol absorption loading, unavailable so far, is crucial for simulating the aerosol climate impacts over Asia which is quite uncertain.},
  language  = {en}
}
@article{AlLabanRegerLucke2022,
  author    = {Al Laban, Firas and Reger, Martin and Lucke, Ulrike},
  title     = {Closing the Policy Gap in the Academic Bridge},
  series = {Education sciences},
  volume    = {12},
  journal   = {Education sciences},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-7102},
  doi       = {10.3390/educsci12120930},
  year      = {2022},
  abstract  = {The highly structured nature of the educational sector demands effective policy mechanisms close to the needs of the field. That is why evidence-based policy making, endorsed by the European Commission under Erasmus+ Key Action 3, aims to make an alignment between the domains of policy and practice. Against this background, this article addresses two issues: First, that there is a vertical gap in the translation of higher-level policies to local strategies and regulations. Second, that there is a horizontal gap between educational domains regarding the policy awareness of individual players. This was analyzed in quantitative and qualitative studies with domain experts from the fields of virtual mobility and teacher training. From our findings, we argue that the combination of both gaps puts the academic bridge from secondary to tertiary education at risk, including the associated knowledge proficiency levels. We discuss the role of digitalization in the academic bridge by asking the question: which value does the involved stakeholders expect from educational policies? As a theoretical basis, we rely on the model of value co-creation for and by stakeholders. We describe the used instruments along with the obtained results and proposed benefits. Moreover, we reflect on the methodology applied, and we finally derive recommendations for future academic bridge policies.},
  language  = {en}
}
@article{AbramovaBatzelModesti2022,
  author    = {Abramova, Olga and Batzel, Katharina and Modesti, Daniela},
  title     = {Collective response to the health crisis among German Twitter users},
  series = {International Journal of Information Management Data Insights},
  volume    = {2},
  journal   = {International Journal of Information Management Data Insights},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2667-0968},
  doi       = {10.1016/j.jjimei.2022.100126},
  pages     = {13},
  year      = {2022},
  abstract  = {We used structural topic modeling to analyze over 800,000 German tweets about COVID-19 to answer the questions: What patterns emerge in tweets as a response to a health crisis? And how do topics discussed change over time? The study leans on the goals associated with the health information seeking (GAINS) model, discerning whether a post aims at tackling and eliminating the problem (i.e., problem-focused) or managing the emotions (i.e., emotion-focused); whether it strives to maximize positive outcomes (promotion focus) or to minimize negative outcomes (prevention focus). The findings indicate four clusters salient in public reactions: 1) "Understanding" (problem-promotion); 2) "Action planning" (problem-prevention); 3) "Hope" (emotion-promotion) and 4) "Reassurance" (emotion-prevention). Public communication is volatile over time, and a shift is evidenced from self-centered to community-centered topics within 4.5 weeks. Our study illustrates social media text mining's potential to quickly and efficiently extract public opinions and reactions. Monitoring fears and trending topics enable policymakers to rapidly respond to deviant behavior, like resistive attitudes toward containment measures or deteriorating physical health. Healthcare workers can use the insights to provide mental health services for battling anxiety or extensive loneliness from staying home.},
  language  = {en}
}
@article{ProlSmirnovHoqueetal.2022,
  author    = {Prol, Fabricio S. and Smirnov, Artem G. and Hoque, M. Mainul and Shprits, Yuri Y.},
  title     = {Combined model of topside ionosphere and plasmasphere derived from radio-occultation and Van Allen Probes data},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Macmillan Publishers Limited, part of Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-13302-1},
  pages     = {11},
  year      = {2022},
  abstract  = {In the last years, electron density profile functions characterized by a linear dependence on the scale height showed good results when approximating the topside ionosphere. The performance above 800 km, however, is not yet well investigated. This study investigates the capability of the semi-Epstein functions to represent electron density profiles from the peak height up to 20,000 km. Electron density observations recorded by the Van Allen Probes were used to resolve the scale height dependence in the plasmasphere. It was found that the linear dependence of the scale height in the topside ionosphere cannot be directly used to extrapolate profiles above 800 km. We find that the dependence of scale heights on altitude is quadratic in the plasmasphere. A statistical model of the scale heights is therefore proposed. After combining the topside ionosphere and plasmasphere by a unified model, we have obtained good estimations not only in the profile shapes, but also in the Total Electron Content magnitude and distributions when compared to actual measurements from 2013, 2014, 2016 and 2017. Our investigation shows that Van Allen Probes can be merged to radio-occultation data to properly represent the upper ionosphere and plasmasphere by means of a semi-Epstein function.},
  language  = {en}
}
@article{WenderingNikoloski2022,
  author    = {Wendering, Philipp and Nikoloski, Zoran},
  title     = {COMMIT},
  series = {PLoS Computational Biology : a new community journal / publ. by the Public Library of Science (PLoS) in association with the International Society for Computational Biology (ISCB)},
  volume    = {18},
  journal   = {PLoS Computational Biology : a new community journal / publ. by the Public Library of Science (PLoS) in association with the International Society for Computational Biology (ISCB)},
  number    = {3},
  publisher = {Public Library of Science},
  address   = {San Fransisco},
  issn      = {1553-734X},
  doi       = {10.1371/journal.pcbi.1009906},
  pages     = {24},
  year      = {2022},
  abstract  = {Composition and functions of microbial communities affect important traits in diverse hosts, from crops to humans. Yet, mechanistic understanding of how metabolism of individual microbes is affected by the community composition and metabolite leakage is lacking. Here, we first show that the consensus of automatically generated metabolic reconstructions improves the quality of the draft reconstructions, measured by comparison to reference models. We then devise an approach for gap filling, termed COMMIT, that considers metabolites for secretion based on their permeability and the composition of the community. By applying COMMIT with two soil communities from the Arabidopsis thaliana culture collection, we could significantly reduce the gap-filling solution in comparison to filling gaps in individual reconstructions without affecting the genomic support. Inspection of the metabolic interactions in the soil communities allows us to identify microbes with community roles of helpers and beneficiaries. Therefore, COMMIT offers a versatile fully automated solution for large-scale modelling of microbial communities for diverse biotechnological applications. <br /> Author summaryMicrobial communities are important in ecology, human health, and crop productivity. However, detailed information on the interactions within natural microbial communities is hampered by the community size, lack of detailed information on the biochemistry of single organisms, and the complexity of interactions between community members. Metabolic models are comprised of biochemical reaction networks based on the genome annotation, and can provide mechanistic insights into community functions. Previous analyses of microbial community models have been performed with high-quality reference models or models generated using a single reconstruction pipeline. However, these models do not contain information on the composition of the community that determines the metabolites exchanged between the community members. In addition, the quality of metabolic models is affected by the reconstruction approach used, with direct consequences on the inferred interactions between community members. Here, we use fully automated consensus reconstructions from four approaches to arrive at functional models with improved genomic support while considering the community composition. We applied our pipeline to two soil communities from the Arabidopsis thaliana culture collection, providing only genome sequences. Finally, we show that the obtained models have 90\% genomic support and demonstrate that the derived interactions are corroborated by independent computational predictions.},
  language  = {en}
}
@article{PotenteLeveilleBourretYousefietal.2022,
  author    = {Potente, Giacomo and L{\´e}veill{\´e}-Bourret, {\´E}tienne and Yousefi, Narjes and Choudhury, Rimjhim Roy and Keller, Barbara and Diop, Seydina Issa and Duijsings, Dani{\"e}l and Pirovano, Walter and Lenhard, Michael and Sz{\"o}v{\´e}nyi, P{\´e}ter and Conti, Elena},
  title     = {Comparative genomics elucidates the origin of a supergene controlling floral heteromorphism},
  series = {Molecular biology and evolution : MBE},
  volume    = {39},
  journal   = {Molecular biology and evolution : MBE},
  number    = {2},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0737-4038},
  doi       = {10.1093/molbev/msac035},
  pages     = {16},
  year      = {2022},
  abstract  = {Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula?},
  language  = {en}
}
@article{Braun2022,
  author    = {Braun, Jean},
  title     = {Comparing the transport-limited and ξ-q models for sediment transport},
  series = {Earth surface dynamics},
  volume    = {10},
  journal   = {Earth surface dynamics},
  number    = {2},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {2196-6311},
  doi       = {10.5194/esurf-10-301-2022},
  pages     = {301 -- 327},
  year      = {2022},
  abstract  = {Here I present a comparison between two of the most widely used reduced-complexity models for the representation of sediment transport and deposition processes, namely the transport-limited (or TL) model and the under-capacity (or xi-q) model more recently developed by Davy and Lague (2009). Using both models, I investigate the behavior of a sedimentary continental system of length L fed by a fixed sedimentary flux from a catchment of size A(0) in a nearby active orogen through which sediments transit to a fixed base level representing a large river, a lake or an ocean. This comparison shows that the two models share the same steady-state solution, for which I derive a simple 1D analytical expression that reproduces the major features of such sedimentary systems: a steep fan that connects to a shallower alluvial plain. The resulting fan geometry obeys basic observational constraints on fan size and slope with respect to the upstream drainage area, A(0). The solution is strongly dependent on the size of the system, L, in comparison to a distance L-0, which is determined by the size of A(0), and gives rise to two fundamentally different types of sedimentary systems: a constrained system where L < L-0 and open systems where L > L-0. I derive simple expressions that show the dependence of the system response time on the system characteristics, such as its length, the size of the upstream catchment area, the amplitude of the incoming sedimentary flux and the respective rate parameters (diffusivity or erodibility) for each of the two models. I show that the xi-q model predicts longer response times. I demonstrate that although the manner in which signals propagates through the sedimentary system differs greatly between the two models, they both predict that perturbations that last longer than the response time of the system can be recorded in the stratigraphy of the sedimentary system and in particular of the fan. Interestingly, the xi-q model predicts that all perturbations in the incoming sedimentary flux will be transmitted through the system, whereas the TL model predicts that rapid perturbations cannot. I finally discuss why and under which conditions these differences are important and propose observational ways to determine which of the two models is most appropriate to represent natural systems.},
  language  = {en}
}