@misc{Gassner2012, type = {Master Thesis}, author = {Gassner, Alexandra Carina}, title = {The character of the core-mantle boundary : a systematic study using PcP}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-63590}, school = {Universit{\"a}t Potsdam}, year = {2012}, abstract = {Assuming that liquid iron alloy from the outer core interacts with the solid silicate-rich lower mantle the influence on the core-mantle reflected phase PcP is studied. If the core-mantle boundary is not a sharp discontinuity, this becomes apparent in the waveform and amplitude of PcP. Iron-silicate mixing would lead to regions of partial melting with higher density which in turn reduces the velocity of seismic waves. On the basis of the calculation and interpretation of short-period synthetic seismograms, using the reflectivity and Gauss Beam method, a model space is evaluated for these ultra-low velocity zones (ULVZs). The aim of this thesis is to analyse the behaviour of PcP between 10° and 40° source distance for such models using different velocity and density configurations. Furthermore, the resolution limits of seismic data are discussed. The influence of the assumed layer thickness, dominant source frequency and ULVZ topography are analysed. The Gr{\"a}fenberg and NORSAR arrays are then used to investigate PcP from deep earthquakes and nuclear explosions. The seismic resolution of an ULVZ is limited both for velocity and density contrasts and layer thicknesses. Even a very thin global core-mantle transition zone (CMTZ), rather than a discrete boundary and also with strong impedance contrasts, seems possible: If no precursor is observable but the PcP_model /PcP_smooth amplitude reduction amounts to more than 10\%, a very thin ULVZ of 5 km with a first-order discontinuity may exist. Otherwise, if amplitude reductions of less than 10\% are obtained, this could indicate either a moderate, thin ULVZ or a gradient mantle-side CMTZ. Synthetic computations reveal notable amplitude variations as function of the distance and the impedance contrasts. Thereby a primary density effect in the very steep-angle range and a pronounced velocity dependency in the wide-angle region can be predicted. In view of the modelled findings, there is evidence for a 10 to 13.5 km thick ULVZ 600 km south-eastern of Moscow with a NW-SE extension of about 450 km. Here a single specific assumption about the velocity and density anomaly is not possible. This is in agreement with the synthetic results in which several models create similar amplitude-waveform characteristics. For example, a ULVZ model with contrasts of -5\% VP , -15\% VS and +5\% density explain the measured PcP amplitudes. Moreover, below SW Finland and NNW of the Caspian Sea a CMB topography can be assumed. The amplitude measurements indicate a wavelength of 200 km and a height of 1 km topography, previously also shown in the study by Kampfmann and M{\"u}ller (1989). Better constraints might be provided by a joined analysis of seismological data, mineralogical experiments and geodynamic modelling.}, language = {en} } @article{HofukuChoNishidaetal.2013, author = {Hofuku, Yoyoi and Cho, Shinya and Nishida, Tomohiro and Kanemune, Susumu}, title = {Why is programming difficult?}, series = {Commentarii informaticae didacticae : (CID)}, journal = {Commentarii informaticae didacticae : (CID)}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-64458}, pages = {13 -- 24}, year = {2013}, abstract = {In this article, we propose a model for an understanding process that learners can use while studying programming. We focus on the "small step" method, in which students learn only a few concepts for one program to avoid having trouble with learning programming. We also analyze the difference in the description order between several C programming textbooks on the basis of the model. We developed a tool to detect "gaps" (a lot of concepts to be learned in a program) in programming textbooks.}, language = {de} } @article{Linck2013, author = {Linck, Barbara}, title = {Test items for and misconceptions of competences in the domain of logic programming}, series = {Commentarii informaticae didacticae : (CID)}, journal = {Commentarii informaticae didacticae : (CID)}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-64461}, pages = {25 -- 34}, year = {2013}, abstract = {Development of competence-oriented curricula is still an important theme in informatics education. Unfortunately informatics curricula, which include the domain of logic programming, are still input-orientated or lack detailed competence descriptions. Therefore, the development of competence model and of learning outcomes' descriptions is essential for the learning process in this domain. A prior research developed both. The next research step is to formulate test items to measure the described learning outcomes. This article describes this procedure and exemplifies test items. It also relates a test in school to the items and shows which misconceptions and typical errors are important to discuss in class. The test result can also confirm or disprove the competence model. Therefore, this school test is important for theoretical research as well as for the concrete planning of lessons. Quantitative analysis in school is important for evaluation and improvement of informatics education.}, language = {en} } @article{KimPark2013, author = {Kim, Seungyon and Park, Seongbin}, title = {Teaching NP completeness in secondary schools}, series = {Commentarii informaticae didacticae : (CID)}, journal = {Commentarii informaticae didacticae : (CID)}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-64476}, pages = {35 -- 38}, year = {2013}, abstract = {In this paper, we show how the theory of NP completeness can be introduced to students in secondary schools. The motivation of this research is that although there are difficult issues that require technical backgrounds, students are already familiar with demanding computational problems through games such as Sudoku or Tetris. Our intention is to bring together important concepts in the theory of NP completeness in such a way that students in secondary schools can easily understand them. This is part of our ongoing research about how to teach fundamental issues in Computer Science in secondary schools. We discuss what needs to be taught in which sequence in order to introduce ideas behind NP completeness to students without technical backgrounds.}, language = {en} } @article{Vaniček2013, author = {Van{\´i}ček, Jiř{\´i}}, title = {Introducing topics from informatics into primary school curricula}, series = {Commentarii informaticae didacticae : (CID)}, journal = {Commentarii informaticae didacticae : (CID)}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-64482}, pages = {41 -- 51}, year = {2013}, abstract = {The process of introducing compulsory ICT education at primary school level in the Czech Republic should be completed next year. Programming and Information, two topics from the basics of computer science have been included in a new textbook. The question is whether the new chapters of the textbook are comprehensible for primary school teachers, who have undergone no training in computer science. The paper reports on a pilot verification project in which pre-service primary school teachers were trained to teach these informatics topics.}, language = {en} } @misc{Peters2013, author = {Peters, Friedrich Ernst}, title = {Friedrich Ernst Peters erz{\"a}hlt D{\"o}ntjes}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-61019}, year = {2013}, abstract = {Heitere Anekdoten um Prominente und weniger Prominente aus Schleswig-Holstein.}, language = {de} } @book{BadoBellingHeroldetal.2014, author = {Bad{\´o}, Attila and Belling, Detlev W. and Herold, Antje and Kneis, Marek and Cheesman, Samantha Joy and Farkas Csamang{\´o}, Erika and Ember, Alex and Hegyes, P{\´e}ter Istv{\´a}n and Nagy, Csongor Istv{\´a}n and Homoki-Nagy, M{\´a}ria and Nagy, Zsolt and Papp, Tekla and Schiffner, Imola and Varga, Norbert}, title = {Rechtsentwicklungen aus europ{\"a}ischer Perspektive im 21. Jahrhundert}, editor = {Bad{\´o}, Attila and Belling, Detlev W.}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-309-1}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-72260}, publisher = {Universit{\"a}t Potsdam}, pages = {289}, year = {2014}, abstract = {Zwischen den Juristischen Fakult{\"a}ten der Universit{\"a}t Szeged und der Universit{\"a}t Potsdam besteht seit etlichen Jahren eine fruchtbare Kooperation in der Lehre. Durch sie entwickelt sich allm{\"a}hlich eine wissenschaftliche Zusammenarbeit. Gemeinsame Konferenzen und Publikationen sind daf{\"u}r ein Beweis. Der vorliegende Band ist das Resultat dieser Kooperation. Der Buchtitel kennzeichnet das Engagement der ungarischen und der deutschen Juristen sowie die gemeinsamen Werte, welche der europ{\"a}ischen Rechtsentwicklung im 21. Jahrhundert zugrunde liegen und die Dogmatik der verschiedenen Rechtsgebiete verkn{\"u}pfen. Die einzelnen Beitr{\"a}ge legen dabei Zeugnis ab von der ganzen Breite der Interessen der ungarischen und deutschen Juristen.}, language = {de} } @phdthesis{Doerge2015, author = {D{\"o}rge, Christina}, title = {Informatische Schl{\"u}sselkompetenzen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-262-9}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-70470}, school = {Universit{\"a}t Potsdam}, pages = {458}, year = {2015}, abstract = {Seit den 60er Jahren gibt es im deutschsprachigen Raum Diskussionen um die Begriffe Schl{\"u}sselqualifikation und (Schl{\"u}ssel-)Kompetenz, welche seit ca. 2000 auch in der Informatikdidaktik angekommen sind. Die Diskussionen der Fachdisziplinen und ihre Bedeutung f{\"u}r die Informatikdidaktik sind Gegenstand des ersten Teils dieser Dissertation. Es werden Rahmenmodelle zur Strukturierung und Einordnung von Kompetenzen entworfen, die f{\"u}r alle Fachdisziplinen nutzbar sind. Im zweiten Teil wird ein methodologischer Weg gezeigt, Schl{\"u}sselkompetenzen herzuleiten, ohne normativ vorgehen zu m{\"u}ssen. Hierzu wird das Verfahren der Qualitativen Inhaltsanalyse (QI) auf informatikdidaktische Ansätze angewendet. Die resultierenden Kompetenzen werden in weiteren Schritten verfeinert und in die zuvor entworfenen Rahmenmodelle eingeordnet. Das Ergebnis sind informatische Schl{\"u}sselkompetenzen, welche ein spezifisches Bild der Informatik zeichnen und zur Analyse bereits bestehender Curricula genutzt werden können. Zusätzlich zeigt das Verfahren einen Weg auf, wie Schl{\"u}sselkompetenzen auf nicht-normativem Wege generell hergeleitet werden können.}, language = {de} } @book{KargSchopperPaschkeetal.2007, author = {Karg, Detlef and Schopper, Franz and Paschke, Ralph and Meyer, Michael and Ackermann, Irmgard and Baxmann, Matthias and Buchinger, Marie-Luise and Cante, Marcus and Dreger, Hans-Joachim and Gramlich, Sybille and Schwarz, Ulrike and H{\"u}bener, Dieter and Metzler, Matthias and Niemann, Alexander and Rohowski, Ilona and Senst, Ingetraud and Groß, Wera}, title = {Denkmalentdeckungen}, editor = {Brandenburgisches Landesamt f{\"u}r Denkmalpflege und Arch{\"a}ologisches Landesmuseum,}, edition = {1200}, publisher = {Wernersche Verlagsgesellschaft}, address = {Worms}, isbn = {978-3-88462-244-5}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-72290}, publisher = {Universit{\"a}t Potsdam}, pages = {288}, year = {2007}, abstract = {»Wenn du reisen willst, mußt du die Geschichte dieses Landes kennen und lieben. Das ist ganz unerl{\"a}ßlich. [...] Wag' es getrost und du wirst es nicht bereuen. Eigent{\"u}mliche Freuden und Gen{\"u}sse werden dich begleiten. Du wirst Entdeckungen machen, denn {\"u}berall wohin du kommst, wirst du, vom Touristenstandpunkt aus, eintreten wie in ›jungfr{\"a}uliches Land‹. Du wirst Klosterruinen begegnen, von deren Existenz h{\"o}chstens die n{\"a}chste Stadt eine leise Kenntnis hatte; du wirst inmitten alter Dorfkirchen, deren zerbr{\"o}ckelter Schindelturm nur auf Elend deutete, große Wandbilder oder in den treppenlosen Gr{\"u}ften reiche Kupfers{\"a}rge mit Kruzifix und vergoldeten Wappenschildern finden; du wirst Schlachtfelder {\"u}berschreiten, Wendenkirchh{\"o}fe, Heidengr{\"a}ber, von denen die Menschen nichts mehr wissen.« Die in diesem Bildband gesammelten »Denkmalentdeckungen« verstehen sich als Einladung zu einer Reise durch das Land Brandenburg. Theodor Fontane hatte f{\"u}r ein solches Unternehmen genau den richtigen Blick, als er in seinen »Wanderungen durch die Mark Brandenburg« 1864 diese S{\"a}tze schrieb. Auch heute noch sollten wir seiner Anregung zu Begegnungen mit der Geschichte und der Kunstgeschichte des Landes folgen, die uns im Dialog der Kulturen und der Zeiten eine Standortbestimmung in der Gegenwart und eine Orientierung f{\"u}r die Zukunft zugleich bietet.}, language = {de} } @article{Schmidt2014, author = {Schmidt, Carmen}, title = {Entstehung und Entwicklung der Verfassung der Russischen F{\"o}deration aus deutscher Sicht}, series = {Verfassungsentwicklung in Russland und Deutschland : Materialien des russisch-deutschen Symposiums anl{\"a}sslich des 20. Jahrestages der Verfassung der Russischen F{\"o}deration am 25. und 26. September 2013 an der Universit{\"a}t Potsdam}, journal = {Verfassungsentwicklung in Russland und Deutschland : Materialien des russisch-deutschen Symposiums anl{\"a}sslich des 20. Jahrestages der Verfassung der Russischen F{\"o}deration am 25. und 26. September 2013 an der Universit{\"a}t Potsdam}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70910}, pages = {65 -- 76}, year = {2014}, language = {de} } @book{OPUS4-6251, title = {Grammatica Grandonica}, editor = {Van Hal, Toon and Vielle, Christophe}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-63218}, publisher = {Universit{\"a}t Potsdam}, pages = {280}, year = {2013}, abstract = {In May 2010, Johann Ernst Hanxleden's Grammatica Grandonica was rediscovered in Montecompatri (Lazio, Rome). Although historiographers attached much weight to the nearly oldest western grammar of Sanskrit, the precious manuscript was lost for several decades. The first aim of the present digital publication is to offer a photographical reproduction of the manuscript. This facsimile is accompanied by a double edition: a facing diplomatic edition with the Sanskrit in Malayāḷam script, followed by a transliterated established text.}, language = {en} } @inproceedings{ArlettazBadoBakosKovacsetal.2014, author = {Arlettaz, Jordane and Bad{\´o}, Attila and Bakos-Kov{\´a}cs, Kitti and Bat{\´o}, Szilvia and B{\´o}ka, J{\´a}nos and Congnard, Laureline and Csatl{\´o}s, Erzs{\´e}bet and Gedeon, Magdolna and Guemar, Carine and Hajd{\´u}, D{\´o}ra and Jacs{\´o}, Judit and Kelemen, Katalin and Fekete, Bal{\´a}zs and Kruzslicz, P{\´e}ter and Mezei, P{\´e}ter and Szűcs, T{\"u}nde and Zolt{\´a}n, P{\´e}teri and Szab{\´o}, B{\´e}la P.}, title = {Internationale Konferenz zum zehnj{\"a}hrigen Bestehen des Instituts f{\"u}r Rechtsvergleichung der Universit{\"a}t Szeged}, editor = {Bad{\´o}, Attila and Belling, Detlev W. and B{\´o}ka, J{\´a}nos and Mezei, P{\´e}ter}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-308-4}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-72039}, pages = {296}, year = {2014}, abstract = {Die Konferenz „International Conference for the 10th Anniversary of the Institute of Comparative Law" hat am 24. Mai 2013 in Szeged stattgefunden. Im Rahmen der viersprachigen Konferenz haben mehr als dreißig Teilnehmer ihre Forschungsergebnisse pr{\"a}sentiert. Der Essay von Zolt{\´a}n P{\´e}teri blickt auf die Disziplin aus der Perspektive der Wissenschaftsgeschichte. Katalin Kelemen und Bal{\´a}zs Fekete gehen in ihrem Aufsatz der Frage nach, welchen Weg die Versuche der Klassifikation der Rechtssysteme von Osteuropa in der sp{\"a}ten Phase der Umbr{\"u}che der 1980/90er Jahren genommen haben. Die historische Betrachtungsweise mit Bezug auf Rechtsgeschichte und Rechtsvergleichung spiegelt sich auch in anderen Essays wider, vor allem in den Aufs{\"a}tzen von Szilvia Bat{\´o}, Magdolna Gedeon und B{\´e}la Szab{\´o} P. sowie auch in den Aufs{\"a}tzen von P{\´e}ter Mezei und T{\"u}nde Szűcs. Attila Bad{\´o} analysiert die Rechtsvergleichung aus der Sicht des Rechts, der Soziologie und der Politikwissenschaft anhand von Untersuchungen {\"u}ber das Sanktionsystem der Richter in den USA. Diese politikwissenschaftliche Seite wird auch in den Aufs{\"a}tzen {\"u}ber die aktuellen Fragen der europ{\"a}ischen Integration von Carine Guemar und Laureline Congnard betont. Eine Reihe von Aufs{\"a}tzen behandeln die konventionelle normative Komparatistik auf dem Gebiet des Verfassungsrechts (Jordane Arlettaz und P{\´e}ter Kruzslicz), Gesellschaftsrechts (Kitti Bakos-Kov{\´a}cs), Urheberrechts (D{\´o}ra Hajd{\´u}) und Steuerrechts (Judit Jacs{\´o}). Daneben bilden eine weitere Gruppe die Aufs{\"a}tze von J{\´a}nos B{\´o}ka und Erzs{\´e}bet Csatl{\´o}s, die die Verwendung der vergleichenden Methode in der Praxis der Rechtsprechung untersuchen. Die Rechtsvergleichung ist eine sich dynamisch entwickelnde Disziplin. Die Konferenz und dieser Band dienen nicht nur der W{\"u}rdigung der bisherigen Arbeit des Instituts f{\"u}r Rechtsvergleichung, sondern zeigen gleichzeitig neue Ziele auf. Die wichtigsten Grunds{\"a}tze bleiben aber fest verankert auch in einem sich stets ver{\"a}ndernden rechtlichen und geistigen Umfeld. Das Motto des Instituts lautet „instruere et docere omnes qui edoceri desiderant" - „alle lehren, die lernen wollen." Auch in den folgenden Jahrzehnten werden uns der Wille des Lernens und Lehrens, die Freiheit der Forschung sowie die {\"U}bertragung und Weiterentwicklung der ungarischen wie globalen Rechtskultur leiten.}, language = {de} } @phdthesis{Oey2008, author = {Oey, Melanie}, title = {Chloroplasts as bioreactors : high-yield production of active bacteriolytic protein antibiotics}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-28950}, school = {Universit{\"a}t Potsdam}, year = {2008}, abstract = {Plants, more precisely their chloroplasts with their bacterial-like expression machinery inherited from their cyanobacterial ancestors, can potentially offer a cheap expression system for proteinaceous pharmaceuticals. This system would be easily scalable and provides appropriate safety due to chloroplasts maternal inheritance. In this work, it was shown that three phage lytic enzymes (Pal, Cpl-1 and PlyGBS) could be successfully expressed at very high levels and with high stability in tobacco chloroplasts. PlyGBS expression reached an amount of foreign protein accumulation (> 70\% TSP) that has never been obtained before. Although the high expression levels of PlyGBS caused a pale green phenotype with retarded growth, presumably due to exhaustion of plastid protein synthesis capacity, development and seed production were not impaired under greenhouse conditions. Since Pal and Cpl-1 showed toxic effects when expressed in E. coli, a special plastid transformation vector (pTox) was constructed to allow DNA amplification in bacteria. The construction of the pTox transformation vector allowing a recombinase-mediated deletion of an E. coli transcription block in the chloroplast, leading to an increase of foreign protein accumulation to up to 40\% of TSP for Pal and 20\% of TSP for Cpl-1. High dose-dependent bactericidal efficiency was shown for all three plant-derived lytic enzymes using their pathogenic target bacteria S. pyogenes and S. pneumoniae. Confirmation of specificity was obtained for the endotoxic proteins Pal and Cpl-1 by application to E. coli cultures. These results establish tobacco chloroplasts as a new cost-efficient and convenient production platform for phage lytic enzymes and address the greatest obstacle for clinical application. The present study is the first report of lysin production in a non-bacterial system. The properties of chloroplast-produced lysins described in this work, their stability, high accumulation rate and biological activity make them highly attractive candidates for future antibiotics.}, language = {en} } @misc{Schrader1994, author = {Schrader, Lutz}, title = {Deutschland und die europ{\"a}ische Sicherheitsagenda}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-28999}, year = {1994}, language = {de} } @phdthesis{Regel2008, author = {Regel, Stefanie}, title = {The comprehension of figurative language : electrophysiological evidence on the processing of irony}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-33376}, school = {Universit{\"a}t Potsdam}, year = {2008}, abstract = {Diese Dissertation untersucht das Verstehen figurativer Sprache, im Besonderen die zeitliche Verarbeitung von verbaler Ironie. In sechs Experimenten wurde mittels ereignis-korrelierter Potentiale (EKP) die Gehirnaktivit{\"a}t beim Verstehen ironischer {\"A}ußerungen im Vergleich zu entsprechenden nicht-ironischen {\"A}ußerungen gemessen und analysiert. Dar{\"u}berhinaus wurde der Einfluss verschiedener sprachbegleitender Hinweisreize, z.B. von Prosodie oder der Verwendung von Satzzeichen, sowie außersprachlicher Hinweisreize, wie bspw. pragmatischen Wissens, auf das Ironieverstehen untersucht. Auf Grundlage dieser Ergebnisse werden verschiedene psycholinguistische Modelle figurativer Sprachverarbeitung, d.h. 'standard pragmatic model', 'graded salience hypothesis', sowie 'direct access view', diskutiert.}, language = {en} } @book{Ludwig2011, author = {Ludwig, Joachim}, title = {Forschungsbasierte Lehre als Lehre im Format der Forschung}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-49858}, publisher = {Universit{\"a}t Potsdam}, year = {2011}, abstract = {Wissenschaftler sind regelm{\"a}ßig mehr an Forschung interessiert als an Lehre. Dies hat verschiedene Gr{\"u}nde, auf die hier nicht im Einzelnen eingegangen werden soll. Einer dieser Gr{\"u}nde liegt im eigenen Professionsverst{\"a}ndnis als Forscher/in bzw. Wissenschaftler/in begr{\"u}ndet. Im Kern geht es dabei um Entdeckungen, um Innovationen, um die Weiterentwicklung vorhandenen Wissens. Lehre wird dem gegen{\"u}ber als intermedi{\"a}rer Bereich gesehen, in dem vorhandenes Wissen reproduziert wird, der deshalb mehr dem Berufssystem zugeh{\"o}rig ist und weniger dem Wissenschaftssystem (Fangmann 2006, S. 30). Lehre erscheint deshalb als Belastung, die mit Forschung nicht korrespondiert, eher von Forschung abh{\"a}lt, insbesondere wenn Studierende den eigenen Lehrbem{\"u}hungen passiv gegen{\"u}berstehen und der Ertrag der Lehre zweifelhaft erscheint. Im Folgenden soll die Verwandtschaft von Forschung und Lernen dargestellt und auf ihre korrespondierenden Logiken verwiesen werden. Grundlage daf{\"u}r ist ein lerntheoretisches Modell, das Lernen subjekttheoretisch als soziales Handeln konzipiert (Holzkamp 1993), das mit Forschen vergleichbar ist. Forschungsbasierte Lehre wird im Kontext einer subjekttheoretischen Didaktik (Ludwig 2006) als Lehre im Format der Forschung vorgestellt, die Lernen unterst{\"u}tzen kann, weil Lernen dem Forschungsprozess {\"a}hnelt. Typen, Ertr{\"a}ge und Umsetzungsprobleme forschungsbasierter Lehre werden kurz skizziert.}, language = {de} } @inproceedings{GoltzPieth2010, author = {Goltz, Hans-Joachim and Pieth, Norbert}, title = {A tool for generating partition schedules of multiprocessor systems}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41556}, year = {2010}, abstract = {A deterministic cycle scheduling of partitions at the operating system level is supposed for a multiprocessor system. In this paper, we propose a tool for generating such schedules. We use constraint based programming and develop methods and concepts for a combined interactive and automatic partition scheduling system. This paper is also devoted to basic methods and techniques for modeling and solving this partition scheduling problem. Initial application of our partition scheduling tool has proved successful and demonstrated the suitability of the methods used.}, language = {en} } @inproceedings{Schrijvers2010, author = {Schrijvers, Tom}, title = {Overview of the monadic constraint programming framework}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41411}, year = {2010}, abstract = {A constraint programming system combines two essential components: a constraint solver and a search engine. The constraint solver reasons about satisfiability of conjunctions of constraints, and the search engine controls the search for solutions by iteratively exploring a disjunctive search tree defined by the constraint program. The Monadic Constraint Programming framework gives a monadic definition of constraint programming where the solver is defined as a monad threaded through the monadic search tree. Search and search strategies can then be defined as firstclass objects that can themselves be built or extended by composable search transformers. Search transformers give a powerful and unifying approach to viewing search in constraint programming, and the resulting constraint programming system is first class and extremely flexible.}, language = {en} } @misc{OPUS4-2878, title = {Geographische Revue: Zeitschrift f{\"u}r Literatur und Diskussion = Geographie und Film}, issn = {1438-3039}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-30436}, year = {2005}, abstract = {Inhalt: Essays: Michael Flitner: Das M{\"a}dchen aus dem Urwald. {\"U}ber Geschlecht und Nation in einem Filmhit der 1950er Jahre Bj{\"o}rn Bollh{\"o}fer und Anke Str{\"u}ver: Geographische Ermittlungen in der M{\"u}nsteraner Filmwelt: Der Fall Wilsberg Helmut Kl{\"u}ter: Kultur als Ordnungshypothese {\"u}ber Raum? Thomas D{\"o}rfler: Geographie und Dekonstruktion. Zu einem zeitgen{\"o}ssischen Missverst{\"a}ndnis Besprechungsaufsatz: Heiner D{\"u}rr: Noch einmal, und zwar gr{\"u}ndlich: Was ist Geographie? Einzelrezensionen}, language = {de} } @phdthesis{Moerbt2010, author = {M{\"o}rbt, Nora}, title = {Differential proteome analysis of human lung epithelial cells following exposure to aromatic volatile organic compounds}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-49257}, school = {Universit{\"a}t Potsdam}, year = {2010}, abstract = {The widespread usage of products containing volatile organic compounds (VOC) has lead to a general human exposure to these chemicals in work places or homes being suspected to contribute to the growing incidence of environmental diseases. Since the causal molecular mechanisms for the development of these disorders are not completely understood, the overall objective of this thesis was to investigate VOC-mediated molecular effects on human lung cells in vitro at VOC concentrations comparable to exposure scenarios below current occupational limits. Although differential expression of single proteins in response to VOCs has been reported, effects on complex protein networks (proteome) have not been investigated. However, this information is indispensable when trying to ascertain a mechanism for VOC action on the cellular level and establishing preventive strategies. For this study, the alveolar epithelial cell line A549 has been used. This cell line, cultured in a two-phase (air/liquid) model allows the most direct exposure and had been successfully applied for the analysis of inflammatory effects in response to VOCs. Mass spectrometric identification of 266 protein spots provided the first proteomic map of A549 cell line to this extent that may foster future work with this frequently used cellular model. The distribution of three typical air contaminants, monochlorobenzene (CB), styrene and 1,2 dichlorobenzene (1,2-DCB), between gas and liquid phase of the exposure model has been analyzed by gas chromatography. The obtained VOC partitioning was in agreement with available literature data. Subsequently the adapted in vitro system has been successfully employed to characterize the effects of the aromatic compound styrene on the proteome of A549 cells (Chapter 4). Initially, the cell toxicity has been assessed in order to ensure that most of the concentrations used in the following proteomic approach were not cytotoxic. Significant changes in abundance and phosphorylation in the total soluble protein fraction of A549 cells have been detected following styrene exposure. All proteins have been identified using mass spectrometry and the main cellular functions have been assigned. Validation experiments on protein and transcript level confirmed the results of the 2-DE experiments. From the results, two main cellular pathways have been identified that were induced by styrene: the cellular oxidative stress response combined with moderate pro-apoptotic signaling. Measurement of cellular reactive oxygen species (ROS) as well as the styrene-mediated induction of oxidative stress marker proteins confirmed the hypothesis of oxidative stress as the main molecular response mechanism. Finally, adducts of cellular proteins with the reactive styrene metabolite styrene 7,8 oxide (SO) have been identified. Especially the SO-adducts observed at both the reactive centers of thioredoxin reductase 1, which is a key element in the control of the cellular redox state, may be involved in styrene-induced ROS formation and apoptosis. A similar proteomic approach has been carried out with the halobenzenes CB and 1,2-DCB (Chapter 5). In accordance with previous findings, cell toxicity assessment showed enhanced toxicity compared to the one caused by styrene. Significant changes in abundance and phosphorylation of total soluble proteins of A549 cells have been detected following exposure to subtoxic concentrations of CB and 1,2-DCB. All proteins have been identified using mass spectrometry and the main cellular functions have been assigned. As for the styrene experiment, the results indicated two main pathways to be affected in the presence of chlorinated benzenes, cell death signaling and oxidative stress response. The strong induction of pro-apoptotic signaling has been confirmed for both treatments by detection of the cleavage of caspase 3. Likewise, the induction of redox-sensitive protein species could be correlated to an increased cellular level of ROS observed following CB treatment. Finally, common mechanisms in the cellular response to aromatic VOCs have been investigated (Chapter 6). A similar number (4.6-6.9\%) of all quantified protein spots showed differential expression (p<0.05) following cell exposure to styrene, CB or 1,2-DCB. However, not more than three protein spots showed significant regulation in the same direction for all three volatile compounds: voltage-dependent anion-selective channel protein 2, peroxiredoxin 1 and elongation factor 2. However, all of these proteins are important molecular targets in stress- and cell death-related signaling pathways.}, language = {en} }