@article{Wallenta2014, author = {Wallenta, Daniel}, title = {A Lefschetz fixed point formula for elliptic quasicomplexes}, series = {Integral equations and operator theor}, volume = {78}, journal = {Integral equations and operator theor}, number = {4}, publisher = {Springer}, address = {Basel}, issn = {0378-620X}, doi = {10.1007/s00020-014-2122-4}, pages = {577 -- 587}, year = {2014}, abstract = {In a recent paper, the Lefschetz number for endomorphisms (modulo trace class operators) of sequences of trace class curvature was introduced. We show that this is a well defined, canonical extension of the classical Lefschetz number and establish the homotopy invariance of this number. Moreover, we apply the results to show that the Lefschetz fixed point formula holds for geometric quasiendomorphisms of elliptic quasicomplexes.}, language = {en} } @unpublished{Wallenta2013, author = {Wallenta, Daniel}, title = {A Lefschetz fixed point formula for elliptic quasicomplexes}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-67016}, year = {2013}, abstract = {In a recent paper with N. Tarkhanov, the Lefschetz number for endomorphisms (modulo trace class operators) of sequences of trace class curvature was introduced. We show that this is a well defined, canonical extension of the classical Lefschetz number and establish the homotopy invariance of this number. Moreover, we apply the results to show that the Lefschetz fixed point formula holds for geometric quasiendomorphisms of elliptic quasicomplexes.}, language = {en} } @unpublished{SchulzeTarkhanov1998, author = {Schulze, Bert-Wolfgang and Tarkhanov, Nikolai Nikolaevich}, title = {A Lefschetz fixed point formula in the relative elliptic theory}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-25159}, year = {1998}, abstract = {A version of the classical Lefschetz fixed point formula is proved for the cohomology of the cone of a cochain mapping of elliptic complexes. As a particular case we show a Lefschetz formula for the relative de Rham cohomology.}, language = {en} } @unpublished{NazaikinskiiSchulzeSterninetal.1997, author = {Nazaikinskii, Vladimir and Schulze, Bert-Wolfgang and Sternin, Boris and Shatalov, Victor}, title = {A Lefschetz fixed point theorem for manifolds with conical singularities}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-25073}, year = {1997}, abstract = {We establish an Atiyah-Bott-Lefschetz formula for elliptic operators on manifolds with conical singular points.}, language = {en} } @article{BoesenbergAlpersBoeckmannetal.1998, author = {B{\"o}senberg, Jens and Alpers, Matthias and B{\"o}ckmann, Christine and J{\"a}ger, Horst and Matthias, Volker and Trickl, Thomas and Wandinger, Ulla and Wiegner, Matthias}, title = {A Lidar Network for the Establishment of an Aerosol Climatology}, year = {1998}, language = {en} } @article{BergemannReich2010, author = {Bergemann, Kay and Reich, Sebastian}, title = {A localization technique for ensemble Kalman filters}, issn = {0035-9009}, doi = {10.1002/Qj.591}, year = {2010}, abstract = {Ensemble Kalman filter techniques are widely used to assimilate observations into dynamical models. The phase- space dimension is typically much larger than the number of ensemble members, which leads to inaccurate results in the computed covariance matrices. These inaccuracies can lead, among other things, to spurious long-range correlations, which can be eliminated by Schur-product-based localization techniques. In this article, we propose a new technique for implementing such localization techniques within the class of ensemble transform/square-root Kalman filters. Our approach relies on a continuous embedding of the Kalman filter update for the ensemble members, i.e. we state an ordinary differential equation (ODE) with solutions that, over a unit time interval, are equivalent to the Kalman filter update. The ODE formulation forms a gradient system with the observations as a cost functional. Besides localization, the new ODE ensemble formulation should also find useful application in the context of nonlinear observation operators and observations that arrive continuously in time.}, language = {en} } @article{MalemShinitskiOpperReichetal.2020, author = {Malem-Shinitski, Noa and Opper, Manfred and Reich, Sebastian and Schwetlick, Lisa and Seelig, Stefan A. and Engbert, Ralf}, title = {A mathematical model of local and global attention in natural scene viewing}, series = {PLoS Computational Biology : a new community journal}, volume = {16}, journal = {PLoS Computational Biology : a new community journal}, number = {12}, publisher = {PLoS}, address = {San Fransisco}, issn = {1553-734X}, doi = {10.1371/journal.pcbi.1007880}, pages = {21}, year = {2020}, abstract = {Author summary
Switching between local and global attention is a general strategy in human information processing. We investigate whether this strategy is a viable approach to model sequences of fixations generated by a human observer in a free viewing task with natural scenes. Variants of the basic model are used to predict the experimental data based on Bayesian inference. Results indicate a high predictive power for both aggregated data and individual differences across observers. The combination of a novel model with state-of-the-art Bayesian methods lends support to our two-state model using local and global internal attention states for controlling eye movements.
Understanding the decision process underlying gaze control is an important question in cognitive neuroscience with applications in diverse fields ranging from psychology to computer vision. The decision for choosing an upcoming saccade target can be framed as a selection process between two states: Should the observer further inspect the information near the current gaze position (local attention) or continue with exploration of other patches of the given scene (global attention)? Here we propose and investigate a mathematical model motivated by switching between these two attentional states during scene viewing. The model is derived from a minimal set of assumptions that generates realistic eye movement behavior. We implemented a Bayesian approach for model parameter inference based on the model's likelihood function. In order to simplify the inference, we applied data augmentation methods that allowed the use of conjugate priors and the construction of an efficient Gibbs sampler. This approach turned out to be numerically efficient and permitted fitting interindividual differences in saccade statistics. Thus, the main contribution of our modeling approach is two-fold; first, we propose a new model for saccade generation in scene viewing. Second, we demonstrate the use of novel methods from Bayesian inference in the field of scan path modeling.}, language = {en} } @article{HartungBorghardt2020, author = {Hartung, Niklas and Borghardt, Jens Markus}, title = {A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs}, series = {PLoS Computational Biology : a new community journal}, volume = {16}, journal = {PLoS Computational Biology : a new community journal}, number = {12}, publisher = {PLoS}, address = {San Fransisco}, issn = {1553-734X}, doi = {10.1371/journal.pcbi.1008466}, pages = {24}, year = {2020}, abstract = {Author summary
The use of orally inhaled drugs for treating lung diseases is appealing since they have the potential for lung selectivity, i.e. high exposure at the site of action -the lung- without excessive side effects. However, the degree of lung selectivity depends on a large number of factors, including physiochemical properties of drug molecules, patient disease state, and inhalation devices. To predict the impact of these factors on drug exposure and thereby to understand the characteristics of an optimal drug for inhalation, we develop a predictive mathematical framework (a "pharmacokinetic model"). In contrast to previous approaches, our model allows combining knowledge from different sources appropriately and its predictions were able to adequately predict different sets of clinical data. Finally, we compare the impact of different factors and find that the most important factors are the size of the inhaled particles, the affinity of the drug to the lung tissue, as well as the rate of drug dissolution in the lung. In contrast to the common belief, the solubility of a drug in the lining fluids is not found to be relevant. These findings are important to understand how inhaled drugs should be designed to achieve best treatment results in patients.
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Even though each single process has been systematically investigated, a quantitative understanding on the interaction of processes remains limited and therefore identifying optimal drug and formulation characteristics for orally inhaled drugs is still challenging. To investigate this complex interplay, the pulmonary processes can be integrated into mathematical models. However, existing modeling attempts considerably simplify these processes or are not systematically evaluated against (clinical) data. In this work, we developed a mathematical framework based on physiologically-structured population equations to integrate all relevant pulmonary processes mechanistically. A tailored numerical resolution strategy was chosen and the mechanistic model was evaluated systematically against data from different clinical studies. Without adapting the mechanistic model or estimating kinetic parameters based on individual study data, the developed model was able to predict simultaneously (i) lung retention profiles of inhaled insoluble particles, (ii) particle size-dependent pharmacokinetics of inhaled monodisperse particles, (iii) pharmacokinetic differences between inhaled fluticasone propionate and budesonide, as well as (iv) pharmacokinetic differences between healthy volunteers and asthmatic patients. Finally, to identify the most impactful optimization criteria for orally inhaled drugs, the developed mechanistic model was applied to investigate the impact of input parameters on both the pulmonary and systemic exposure. Interestingly, the solubility of the inhaled drug did not have any relevant impact on the local and systemic pharmacokinetics. Instead, the pulmonary dissolution rate, the particle size, the tissue affinity, and the systemic clearance were the most impactful potential optimization parameters. In the future, the developed prediction framework should be considered a powerful tool for identifying optimal drug and formulation characteristics.}, language = {en} } @article{LeimkuhlerReich2009, author = {Leimkuhler, Benedict and Reich, Sebastian}, title = {A metropolis adjusted Nos{\ยดe}-Hoover thermostat}, issn = {0764-583X}, doi = {10.1051/M2an/2009023}, year = {2009}, abstract = {We present a Monte Carlo technique for sampling from the canonical distribution in molecular dynamics. The method is built upon the Nose-Hoover constant temperature formulation and the generalized hybrid Monte Carlo method. In contrast to standard hybrid Monte Carlo methods only the thermostat degree of freedom is stochastically resampled during a Monte Carlo step.}, language = {en} } @article{Boeckmann1995, author = {B{\"o}ckmann, Christine}, title = {A modification of the trust-region Gauss-Newton method to solve separable nonlinear least squares problems}, year = {1995}, language = {en} } @book{Boeckmann1992, author = {B{\"o}ckmann, Christine}, title = {A modification of the Trust-Region Gauss-Newton method to solve separable nonlinear least squares problems}, series = {Preprint / Universit{\"a}t Potsdam, Fachbereich Mathematik}, volume = {1992, 17}, journal = {Preprint / Universit{\"a}t Potsdam, Fachbereich Mathematik}, publisher = {Univ.}, address = {Potsdam}, pages = {14 Bl.}, year = {1992}, language = {en} } @book{Baumgaertel1994, author = {Baumg{\"a}rtel, Hellmut}, title = {A modified approach to the Doplicher-Roberts theorem on the construction of field algebra and the symmetry group in superselection theory}, series = {Preprint / SFB 288, Differentialgeometrie und Quantenphysik}, volume = {134}, journal = {Preprint / SFB 288, Differentialgeometrie und Quantenphysik}, address = {Berlin}, pages = {33 S.}, year = {1994}, language = {en} } @article{Baumgaertel1997, author = {Baumg{\"a}rtel, Hellmut}, title = {A modified approach to the Doplicher-Roberts theorem on the construction of the field algebra and the symmetry group in superselection theory}, year = {1997}, language = {en} } @article{PornsawadSapsakulBoeckmann2019, author = {Pornsawad, Pornsarp and Sapsakul, Nantawan and B{\"o}ckmann, Christine}, title = {A modified asymptotical regularization of nonlinear ill-posed problems}, series = {Mathematics}, volume = {7}, journal = {Mathematics}, edition = {5}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2227-7390}, doi = {10.3390/math7050419}, pages = {19}, year = {2019}, abstract = {In this paper, we investigate the continuous version of modified iterative Runge-Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of โˆฅ๐น(๐‘ฅ๐›ฟ(๐‘‡))-๐‘ฆ๐›ฟโˆฅ=๐œ๐›ฟ+ for some ๐›ฟ+>๐›ฟ, and an appropriate source condition. We yield the optimal rate of convergence.}, language = {en} } @misc{PornsawadSapsakulBoeckmann2019, author = {Pornsawad, Pornsarp and Sapsakul, Nantawan and B{\"o}ckmann, Christine}, title = {A modified asymptotical regularization of nonlinear ill-posed problems}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1335}, issn = {1866-8372}, doi = {10.25932/publishup-47343}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473433}, pages = {19}, year = {2019}, abstract = {In this paper, we investigate the continuous version of modified iterative Runge-Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of โˆฅ๐น(๐‘ฅ๐›ฟ(๐‘‡))-๐‘ฆ๐›ฟโˆฅ=๐œ๐›ฟ+ for some ๐›ฟ+>๐›ฟ, and an appropriate source condition. We yield the optimal rate of convergence.}, language = {en} } @book{Ramlau1997, author = {Ramlau, Ronny}, title = {A modified Landweber-method for inverse problems}, series = {Preprint / Universit{\"a}t Potsdam, Institut f{\"u}r Mathematik}, volume = {1997, 03}, journal = {Preprint / Universit{\"a}t Potsdam, Institut f{\"u}r Mathematik}, publisher = {Univ.}, address = {Potsdam}, pages = {24 Bl.}, year = {1997}, language = {en} } @article{BergemannReich2010, author = {Bergemann, Kay and Reich, Sebastian}, title = {A mollified ensemble Kalman filter}, issn = {0035-9009}, doi = {10.1002/Qj.672}, year = {2010}, abstract = {It is well recognized that discontinuous analysis increments of sequential data assimilation systems, such as ensemble Kalman filters, might lead to spurious high-frequency adjustment processes in the model dynamics. Various methods have been devised to spread out the analysis increments continuously over a fixed time interval centred about the analysis time. Among these techniques are nudging and incremental analysis updates (IAU). Here we propose another alternative, which may be viewed as a hybrid of nudging and IAU and which arises naturally from a recently proposed continuous formulation of the ensemble Kalman analysis step. A new slow-fast extension of the popular Lorenz-96 model is introduced to demonstrate the properties of the proposed mollified ensemble Kalman filter.}, language = {en} } @book{BoeckmannNiebsch1996, author = {B{\"o}ckmann, Christine and Niebsch, Jenny}, title = {A mollifier method for aerosol size}, series = {Preprint / Universit{\"a}t Potsdam, Institut f{\"u}r Mathematik}, volume = {1996, 07}, journal = {Preprint / Universit{\"a}t Potsdam, Institut f{\"u}r Mathematik}, publisher = {Univ.}, address = {Potsdam}, pages = {[5] Bl.}, year = {1996}, language = {en} } @phdthesis{Zass2021, author = {Zass, Alexander}, title = {A multifaceted study of marked Gibbs point processes}, doi = {10.25932/publishup-51277}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-512775}, school = {Universit{\"a}t Potsdam}, pages = {vii, 104}, year = {2021}, abstract = {This thesis focuses on the study of marked Gibbs point processes, in particular presenting some results on their existence and uniqueness, with ideas and techniques drawn from different areas of statistical mechanics: the entropy method from large deviations theory, cluster expansion and the Kirkwood--Salsburg equations, the Dobrushin contraction principle and disagreement percolation. We first present an existence result for infinite-volume marked Gibbs point processes. More precisely, we use the so-called entropy method (and large-deviation tools) to construct marked Gibbs point processes in R^d under quite general assumptions. In particular, the random marks belong to a general normed space S and are not bounded. Moreover, we allow for interaction functionals that may be unbounded and whose range is finite but random. The entropy method relies on showing that a family of finite-volume Gibbs point processes belongs to sequentially compact entropy level sets, and is therefore tight. We then present infinite-dimensional Langevin diffusions, that we put in interaction via a Gibbsian description. In this setting, we are able to adapt the general result above to show the existence of the associated infinite-volume measure. We also study its correlation functions via cluster expansion techniques, and obtain the uniqueness of the Gibbs process for all inverse temperatures ฮฒ and activities z below a certain threshold. This method relies in first showing that the correlation functions of the process satisfy a so-called Ruelle bound, and then using it to solve a fixed point problem in an appropriate Banach space. The uniqueness domain we obtain consists then of the model parameters z and ฮฒ for which such a problem has exactly one solution. Finally, we explore further the question of uniqueness of infinite-volume Gibbs point processes on R^d, in the unmarked setting. We present, in the context of repulsive interactions with a hard-core component, a novel approach to uniqueness by applying the discrete Dobrushin criterion to the continuum framework. We first fix a discretisation parameter a>0 and then study the behaviour of the uniqueness domain as a goes to 0. With this technique we are able to obtain explicit thresholds for the parameters z and ฮฒ, which we then compare to existing results coming from the different methods of cluster expansion and disagreement percolation. Throughout this thesis, we illustrate our theoretical results with various examples both from classical statistical mechanics and stochastic geometry.}, language = {en} } @article{ShinZoellerHolschneideretal.2011, author = {Shin, Seoleun and Z{\"o}ller, Gert and Holschneider, Matthias and Reich, Sebastian}, title = {A multigrid solver for modeling complex interseismic stress fields}, series = {Computers \& geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology}, volume = {37}, journal = {Computers \& geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology}, number = {8}, publisher = {Elsevier}, address = {Oxford}, issn = {0098-3004}, doi = {10.1016/j.cageo.2010.11.011}, pages = {1075 -- 1082}, year = {2011}, abstract = {We develop a multigrid, multiple time stepping scheme to reduce computational efforts for calculating complex stress interactions in a strike-slip 2D planar fault for the simulation of seismicity. The key elements of the multilevel solver are separation of length scale, grid-coarsening, and hierarchy. In this study the complex stress interactions are split into two parts: the first with a small contribution is computed on a coarse level, and the rest for strong interactions is on a fine level. This partition leads to a significant reduction of the number of computations. The reduction of complexity is even enhanced by combining the multigrid with multiple time stepping. Computational efficiency is enhanced by a factor of 10 while retaining a reasonable accuracy, compared to the original full matrix-vortex multiplication. The accuracy of solution and computational efficiency depend on a given cut-off radius that splits multiplications into the two parts. The multigrid scheme is constructed in such a way that it conserves stress in the entire half-space.}, language = {en} }