@article{LyTarkhanov2020, author = {Ly, Ibrahim and Tarkhanov, Nikolaj Nikolaevič}, title = {Asymptotic expansions at nonsymmetric cuspidal points}, series = {Mathematical notes}, volume = {108}, journal = {Mathematical notes}, number = {1-2}, publisher = {Springer Science}, address = {New York}, issn = {0001-4346}, doi = {10.1134/S0001434620070238}, pages = {219 -- 228}, year = {2020}, abstract = {We study the asymptotics of solutions to the Dirichlet problem in a domain X subset of R3 whose boundary contains a singular point O. In a small neighborhood of this point, the domain has the form {z > root x(2) + y(4)}, i.e., the origin is a nonsymmetric conical point at the boundary. So far, the behavior of solutions to elliptic boundary-value problems has not been studied sufficiently in the case of nonsymmetric singular points. This problem was posed by V.A. Kondrat'ev in 2000. We establish a complete asymptotic expansion of solutions near the singular point.}, language = {en} } @article{Clavier2020, author = {Clavier, Pierre J.}, title = {Double shuffle relations for arborified zeta values}, series = {Journal of algebra}, volume = {543}, journal = {Journal of algebra}, publisher = {Elsevier}, address = {San Diego}, issn = {0021-8693}, doi = {10.1016/j.jalgebra.2019.10.015}, pages = {111 -- 155}, year = {2020}, abstract = {Arborified zeta values are defined as iterated series and integrals using the universal properties of rooted trees. This approach allows to study their convergence domain and to relate them to multiple zeta values. Generalisations to rooted trees of the stuffle and shuffle products are defined and studied. It is further shown that arborified zeta values are algebra morphisms for these new products on trees.}, language = {en} } @article{HammPelivanGrottetal.2020, author = {Hamm, Maximilian and Pelivan, Ivanka and Grott, Matthias and de Wiljes, Jana}, title = {Thermophysical modelling and parameter estimation of small solar system bodies via data assimilation}, series = {Monthly notices of the Royal Astronomical Society}, volume = {496}, journal = {Monthly notices of the Royal Astronomical Society}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/staa1755}, pages = {2776 -- 2785}, year = {2020}, abstract = {Deriving thermophysical properties such as thermal inertia from thermal infrared observations provides useful insights into the structure of the surface material on planetary bodies. The estimation of these properties is usually done by fitting temperature variations calculated by thermophysical models to infrared observations. For multiple free model parameters, traditional methods such as least-squares fitting or Markov chain Monte Carlo methods become computationally too expensive. Consequently, the simultaneous estimation of several thermophysical parameters, together with their corresponding uncertainties and correlations, is often not computationally feasible and the analysis is usually reduced to fitting one or two parameters. Data assimilation (DA) methods have been shown to be robust while sufficiently accurate and computationally affordable even for a large number of parameters. This paper will introduce a standard sequential DA method, the ensemble square root filter, for thermophysical modelling of asteroid surfaces. This method is used to re-analyse infrared observations of the MARA instrument, which measured the diurnal temperature variation of a single boulder on the surface of near-Earth asteroid (162173) Ryugu. The thermal inertia is estimated to be 295 +/- 18 Jm(-2) K-1 s(-1/2), while all five free parameters of the initial analysis are varied and estimated simultaneously. Based on this thermal inertia estimate the thermal conductivity of the boulder is estimated to be between 0.07 and 0.12,Wm(-1) K-1 and the porosity to be between 0.30 and 0.52. For the first time in thermophysical parameter derivation, correlations and uncertainties of all free model parameters are incorporated in the estimation procedure that is more than 5000 times more efficient than a comparable parameter sweep.}, language = {en} } @article{LudewigRoos2020, author = {Ludewig, Matthias and Roos, Saskia}, title = {The chiral anomaly of the free fermion in functorial field theory}, series = {Annales Henri Poincar{\´e} : a journal of theoretical and mathematical physics}, volume = {21}, journal = {Annales Henri Poincar{\´e} : a journal of theoretical and mathematical physics}, number = {4}, publisher = {Springer International Publishing AG}, address = {Cham (ZG)}, issn = {1424-0637}, doi = {10.1007/s00023-020-00893-6}, pages = {1191 -- 1233}, year = {2020}, abstract = {When trying to cast the free fermion in the framework of functorial field theory, its chiral anomaly manifests in the fact that it assigns the determinant of the Dirac operator to a top-dimensional closed spin manifold, which is not a number as expected, but an element of a complex line. In functorial field theory language, this means that the theory is twisted, which gives rise to an anomaly theory. In this paper, we give a detailed construction of this anomaly theory, as a functor that sends manifolds to infinite-dimensional Clifford algebras and bordisms to bimodules.}, language = {en} } @article{HartungBorghardt2020, author = {Hartung, Niklas and Borghardt, Jens Markus}, title = {A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs}, series = {PLoS Computational Biology : a new community journal}, volume = {16}, journal = {PLoS Computational Biology : a new community journal}, number = {12}, publisher = {PLoS}, address = {San Fransisco}, issn = {1553-734X}, doi = {10.1371/journal.pcbi.1008466}, pages = {24}, year = {2020}, abstract = {Author summary
The use of orally inhaled drugs for treating lung diseases is appealing since they have the potential for lung selectivity, i.e. high exposure at the site of action -the lung- without excessive side effects. However, the degree of lung selectivity depends on a large number of factors, including physiochemical properties of drug molecules, patient disease state, and inhalation devices. To predict the impact of these factors on drug exposure and thereby to understand the characteristics of an optimal drug for inhalation, we develop a predictive mathematical framework (a "pharmacokinetic model"). In contrast to previous approaches, our model allows combining knowledge from different sources appropriately and its predictions were able to adequately predict different sets of clinical data. Finally, we compare the impact of different factors and find that the most important factors are the size of the inhaled particles, the affinity of the drug to the lung tissue, as well as the rate of drug dissolution in the lung. In contrast to the common belief, the solubility of a drug in the lining fluids is not found to be relevant. These findings are important to understand how inhaled drugs should be designed to achieve best treatment results in patients.
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Even though each single process has been systematically investigated, a quantitative understanding on the interaction of processes remains limited and therefore identifying optimal drug and formulation characteristics for orally inhaled drugs is still challenging. To investigate this complex interplay, the pulmonary processes can be integrated into mathematical models. However, existing modeling attempts considerably simplify these processes or are not systematically evaluated against (clinical) data. In this work, we developed a mathematical framework based on physiologically-structured population equations to integrate all relevant pulmonary processes mechanistically. A tailored numerical resolution strategy was chosen and the mechanistic model was evaluated systematically against data from different clinical studies. Without adapting the mechanistic model or estimating kinetic parameters based on individual study data, the developed model was able to predict simultaneously (i) lung retention profiles of inhaled insoluble particles, (ii) particle size-dependent pharmacokinetics of inhaled monodisperse particles, (iii) pharmacokinetic differences between inhaled fluticasone propionate and budesonide, as well as (iv) pharmacokinetic differences between healthy volunteers and asthmatic patients. Finally, to identify the most impactful optimization criteria for orally inhaled drugs, the developed mechanistic model was applied to investigate the impact of input parameters on both the pulmonary and systemic exposure. Interestingly, the solubility of the inhaled drug did not have any relevant impact on the local and systemic pharmacokinetics. Instead, the pulmonary dissolution rate, the particle size, the tissue affinity, and the systemic clearance were the most impactful potential optimization parameters. In the future, the developed prediction framework should be considered a powerful tool for identifying optimal drug and formulation characteristics.}, language = {en} } @phdthesis{Reinhardt2020, author = {Reinhardt, Maria}, title = {Hybrid filters and multi-scale models}, doi = {10.25932/publishup-47435}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-474356}, school = {Universit{\"a}t Potsdam}, pages = {xiii, 102}, year = {2020}, abstract = {This thesis is concerned with Data Assimilation, the process of combining model predictions with observations. So called filters are of special interest. One is inter- ested in computing the probability distribution of the state of a physical process in the future, given (possibly) imperfect measurements. This is done using Bayes' rule. The first part focuses on hybrid filters, that bridge between the two main groups of filters: ensemble Kalman filters (EnKF) and particle filters. The first are a group of very stable and computationally cheap algorithms, but they request certain strong assumptions. Particle filters on the other hand are more generally applicable, but computationally expensive and as such not always suitable for high dimensional systems. Therefore it exists a need to combine both groups to benefit from the advantages of each. This can be achieved by splitting the likelihood function, when assimilating a new observation and treating one part of it with an EnKF and the other part with a particle filter. The second part of this thesis deals with the application of Data Assimilation to multi-scale models and the problems that arise from that. One of the main areas of application for Data Assimilation techniques is predicting the development of oceans and the atmosphere. These processes involve several scales and often balance rela- tions between the state variables. The use of Data Assimilation procedures most often violates relations of that kind, which leads to unrealistic and non-physical pre- dictions of the future development of the process eventually. This work discusses the inclusion of a post-processing step after each assimilation step, in which a minimi- sation problem is solved, which penalises the imbalance. This method is tested on four different models, two Hamiltonian systems and two spatially extended models, which adds even more difficulties.}, language = {en} } @misc{PornsawadSungcharoenBoeckmann2020, author = {Pornsawad, Pornsarp and Sungcharoen, Parada and B{\"o}ckmann, Christine}, title = {Convergence rate of the modified Landweber method for solving inverse potential problems}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1034}, issn = {1866-8372}, doi = {10.25932/publishup-47194}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-471942}, pages = {24}, year = {2020}, abstract = {In this paper, we present the convergence rate analysis of the modified Landweber method under logarithmic source condition for nonlinear ill-posed problems. The regularization parameter is chosen according to the discrepancy principle. The reconstructions of the shape of an unknown domain for an inverse potential problem by using the modified Landweber method are exhibited.}, language = {en} } @article{Zagrebnov2020, author = {Zagrebnov, Valentin}, title = {Trotter product formula on Hilbert and Banach spaces for operator-norm convergence}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47197}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-471971}, pages = {23 -- 34}, year = {2020}, language = {en} } @article{Zass2020, author = {Zass, Alexander}, title = {A Gibbs point process of diffusions: Existence and uniqueness}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47195}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-471951}, pages = {13 -- 22}, year = {2020}, language = {en} } @article{SukiasyanMelkonyan2020, author = {Sukiasyan, Hayk and Melkonyan, Tatev}, title = {Semi-recursive algorithm of piecewise linear approximation of two-dimensional function by the method of worst segment dividing}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47198}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-471982}, pages = {35 -- 44}, year = {2020}, language = {en} } @article{BoldrighiniFrigioMaponietal.2020, author = {Boldrighini, Carlo and Frigio, Sandro and Maponi, Pierluigi and Pellegrinotti, Alessandro and Sinai, Yakov G.}, title = {3-D incompressible Navier-Stokes equations: Complex blow-up and related real flows}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47220}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472201}, pages = {185 -- 194}, year = {2020}, language = {en} } @article{FigariTeta2020, author = {Figari, Rodolfo and Teta, Alessandro}, title = {Zero-range hamiltonians for three quantum particles}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47218}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472189}, pages = {175 -- 184}, year = {2020}, language = {en} } @article{Houdebert2020, author = {Houdebert, Pierre}, title = {Numerical study for the phase transition of the area-interaction model}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47217}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472177}, pages = {165 -- 174}, year = {2020}, language = {en} } @article{JansenKunaTsagkarogiannis2020, author = {Jansen, Sabine and Kuna, Tobias and Tsagkarogiannis, Dimitrios}, title = {Virial inversion for inhomogeneous systems}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47211}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472111}, pages = {135 -- 144}, year = {2020}, language = {en} } @article{HrynivWallace2020, author = {Hryniv, Ostap and Wallace, Clare}, title = {Phase separation and sharp large deviations}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47216}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472168}, pages = {155 -- 164}, year = {2020}, language = {en} } @article{JansenKolesnikov2020, author = {Jansen, Sabine and Kolesnikov, Leonid}, title = {Activity expansions for Gibbs correlation functions}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47212}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472121}, pages = {145 -- 154}, year = {2020}, language = {en} } @article{JansenTsagkarogiannis2020, author = {Jansen, Sabine and Tsagkarogiannis, Dimitrios}, title = {Mayer expansion for the Asakura-Oosawa model of colloid theory}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47210}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472109}, pages = {127 -- 134}, year = {2020}, language = {en} } @article{PiatnitskiZhizhina2020, author = {Piatnitski, Andrey and Zhizhina, Elena}, title = {Non-local convolution type parabolic equations with fractional and regular time derivative}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47202}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472024}, pages = {65 -- 67}, year = {2020}, language = {en} } @article{Jursenas2020, author = {Jursenas, Rytis}, title = {The peak model for finite rank supersingular perturbations}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-47209}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472090}, pages = {117 -- 126}, year = {2020}, language = {en} } @article{Mazzonetto2020, author = {Mazzonetto, Sara}, title = {On an approximation of 2-D stochastic Navier-Stokes equations}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-485-2}, issn = {2199-4951}, doi = {10.25932/publishup-47205}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472053}, pages = {87 -- 96}, year = {2020}, language = {en} }