@phdthesis{Fliesser2018,
  author    = {Fließer, Michael},
  title     = {Der Einfluss unterschiedlicher Indikatoren des sozio{\"o}konomischen Status auf R{\"u}ckenschmerz},
  doi       = {10.25932/publishup-42345},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-423455},
  school      = {Universit{\"a}t Potsdam},
  pages     = {84},
  year      = {2018},
  abstract  = {Obwohl der sozio{\"o}konomische Status (SES) eine in der Sozialepidemiologie h{\"a}ufig gebrauchte Variable darstellt, ist seine Verwendung mit methodischen Problemen verkn{\"u}pft: Seine latente Struktur f{\"u}hrt dazu, dass sich verschiedene M{\"o}glichkeiten der Operationalisierung er{\"o}ffnen. Diese reichen von klassischen Ungleichheitsindikatoren wie Bildung, Einkommen oder Berufsposition, {\"u}ber multidimensionale oder {\"u}ber Nachbarschaftsmerkmale konstruierte Indizes, bis hin zu subjektiven Statuseinsch{\"a}tzungen. Problematisch ist dies insofern, als verschiedene Indikatoren auf unterschiedlichen theoretischen Konstrukten beruhen und unterschiedliche Schlussfolgerungen erlauben. In dieser Arbeit wird deshalb in einem ersten Schritt anhand eines systematischen Reviews zum Zusammenhang von SES und R{\"u}ckenschmerzen {\"u}berpr{\"u}ft, welche Indikatoren in wissenschaftlichen Publikationen eingesetzt werden und wie die Auswahl begr{\"u}ndet wird. Das Ergebnis zeigt eine klare Pr{\"a}ferenz f{\"u}r klassische Indikatoren (Bildung, Einkommen und Berufsposition). Erl{\"a}utert wurde die jeweilige Auswahl allerdings nur in einem geringen Prozentsatz der untersuchten Artikel, obwohl die unterschiedlichen Studienergebnisse nahelegen, dass der gew{\"a}hlte Indikator einen Einfluss auf den gefundenen Zusammenhang aus{\"u}ben k{\"o}nnte. Deshalb wurde in einem weiteren Schritt {\"u}berpr{\"u}ft, wie unterschiedliche SES-Indikatoren mit der Verbesserung von R{\"u}ckenschmerzen nach einer Rehabilitation (Studie 1) und der Neuentstehung von R{\"u}ckenschmerzen (Studie 2) zusammenh{\"a}ngen. Außerdem wurde untersucht, ob ein einfaches Modell den Zusammenhang von SES und Gesundheit so darstellen kann, dass a priori abzusch{\"a}tzen ist, wie hoch der Einfluss unterschiedlicher Indikatoren auf einen bestimmten Gesundheitsoutput sein k{\"o}nnte. Es zeigt sich, dass sich der errechnete Zusammenhang zwischen den verschiedenen Indikatoren und chronischen R{\"u}ckenschmerzen erheblich unterscheidet: F{\"u}r Menschen, die bereits wegen R{\"u}ckenschmerzen in Rehabilitation waren, erwiesen sich Bildung und Berufsposition als {\"a}hnlich einflussreiche Einflussfaktoren, w{\"a}hrend f{\"u}r das Einkommen kein bedeutender Zusammenhang festgestellt werden konnte. F{\"u}r die Neuentstehung chronischer R{\"u}ckenschmerzen zeigte sich die Berufsposition als wichtigster Indikator, gefolgt von Bildung, w{\"a}hrend f{\"u}r Einkommen kein signifikanter Zusammenhang gefunden werden konnte. Folglich bestimmt die Wahl des Indikators die H{\"o}he des festgestellten Zusammenhangs stark mit. Unterschiedliche Indikatoren d{\"u}rfen deshalb nicht als austauschbar betrachtet werden und es muss bei jeder Forschungsfrage genau {\"u}berlegt werden, welcher Indikator f{\"u}r die jeweilige Fragestellung am besten verwendet werden kann. Das vorgeschlagene theoretische Modell kann dabei als Unterst{\"u}tzung dienen.},
  language  = {de}
}
@phdthesis{He2023,
  author    = {He, Yangyang},
  title     = {Extracellular vesicles as the potential mediators of psychosocial stress contribution to osteoporosis},
  doi       = {10.25932/publishup-59437},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-594372},
  school      = {Universit{\"a}t Potsdam},
  pages     = {70},
  year      = {2023},
  abstract  = {Background: The characteristics of osteoporosis are decreased bone mass and destruction towards the microarchitecture of bone tissue, which raises the risk of fracture. Psychosocialstress and osteoporosis are linked by sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and other endocrine factors. Psychosocial stress causes a series of effects on the organism, and this long-term depletion at the cellular level is considered to be mitochondrial allostatic load, including mitochondrial dysfunction and oxidative stress. Extracellular vesicles (EVs) are involved in the mitochondrial allostatic load process and may as biomarkers in this setting. As critical participants during cell-to-cell communications, EVs serve as transport vehicles for nucleic acid and proteins, alter the phenotypic and functional characteristics of their target cells, and promote cell-to-cell contact. And hence, they play a significant role in the diagnosis and therapy of many diseases, such as osteoporosis. Aim: This narrative review attempts to outline the features of EVs, investigate their involvement in both psychosocial stress and osteoporosis, and analyze if EVs can be potential mediators between both. Methods: The online database from PubMed, Google Scholar, and Science Direct were searched for keywords related to the main topic of this study, and the availability of all the selected studies was verified. Afterward, the findings from the articles were summarized and synthesized. Results: Psychosocial stress affects bone remodeling through increased neurotransmitters such as glucocorticoids and catecholamines, as well as increased glucose metabolism. Furthermore, psychosocial stress leads to mitochondrial allostatic load, including oxidative stress, which may affect bone remodeling. In vitro and in vivo data suggest EVs might involve in the link between psychosocial stress and bone remodeling through the transfer of bioactive substances and thus be a potential mediator of psychosocial stress leading to osteoporosis. Conclusions: According to the included studies, psychosocial stress affects bone remodeling, leading to osteoporosis. By summarizing the specific properties of EVs and the function of EVs in both psychosocial stress and osteoporosis, respectively, it has been demonstrated that EVs are possible mediators of both, and have the prospects to be useful in innovative research areas.},
  language  = {en}
}
@phdthesis{Lin2021,
  author    = {Lin, Chiao-I},
  title     = {The survey of the prevalence of chronic ankle instability in elite Taiwanese basketball athletes},
  doi       = {10.25932/publishup-53553},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-535534},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xi, 128},
  year      = {2021},
  abstract  = {BACKGROUND: Ankle sprains are common in basketball. It could develop into Chronic Ankle Instability (CAI) causing decreased quality of life, functional performance, early osteoarthritis, and increased risk of other injuries. To develop a strategy of CAI prevention, localized epidemiology data and a valid/reliable tool are essential. However, the epidemiological data of CAI is not conclusive from previous studies and the prevalence of CAI in Taiwanese basketball athletes are not clear. In addition, a valid and reliable tool among the Taiwan-Chinese version to evaluate ankle instability is missing. PURPOSE: The aims were to have an overview of the prevalence of CAI in sports population using a systematic review, to develop a valid and reliable cross-cultural adapted Cumberland Ankle Instability Tool Questionnaire (CAIT) in Taiwan-Chinese (CAIT-TW), and to survey the prevalence of CAI in elite basketball athletes in Taiwan using CAIT-TW. METHODS: Firstly, a systematic search was conducted. Research articles applying CAI related questionnaires in order to survey the prevalence of CAI were included in the review. Second, the English version of CAIT was translated and cross-culturally adapted into the CAIT-TW. The construct validity, test-retest reliability, internal consistency, and cutoff score of CAIT-TW were evaluated in an athletic population (N=135). Finally, the cross-sectional data of CAI prevalence in 388 elite Taiwanese basketball athletes were presented. Demographics, presence of CAI, and difference of prevalence between gender, different competitive levels and play positions were evaluated. RESULTS: The prevalence of CAI was 25\%, ranging between 7\% and 53\%. The prevalence of CAI among participants with a history of ankle sprains was 46\%, ranging between 9\% and 76\%. In addition, the cross-cultural adapted CAIT-TW showed a moderate to strong construct validity, an excellent test-retest reliability, a good internal consistency, and a cutoff score of 21.5 for the Taiwanese athletic population. Finally, 26\% of Taiwanese basketball athletes had unilateral CAI while 50\% of them had bilateral CAI. In addition, women athletes in the investigated cohort had a higher prevalence of CAI than men. There was no difference in prevalence between competitive levels and among play positions. CONCLUSION: The systematic review shows that the prevalence of CAI has a wide range among included studies. This could be due to the different exclusion criteria, age, sports discipline, or other factors among the included studies. For future studies, standardized criteria to investigate the epidemiology of CAI are required. The CAI epidemiological study should be prospective. Factors affecting the prevalence of CAI ability should be investigated and described. The translated CAIT-TW is a valid and reliable tool to differentiate between stable and unstable ankles in athletes and may further apply for research or daily practice in Taiwan. In the Taiwanese basketball population, CAI is highly prevalent. This might relate to the research method, preexisting ankle instability, and training-related issues. Women showed a higher prevalence of CAI than men. When applying the preventive measure, gender should be taken into consideration.},
  language  = {en}
}