@article{YangDingKochovskietal.2017,
  author    = {Yang, Guang and Ding, Hong-ming and Kochovski, Zdravko and Hu, Rongting and Lu, Yan and Ma, Yu-qiang and Chen, Guosong and Jiang, Ming},
  title     = {Highly Ordered Self-Assembly of Native Proteins into 1D, 2D, and 3D Structures Modulated by the Tether Length of Assembly-Inducing Ligands},
  series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition},
  volume    = {56},
  journal   = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1433-7851},
  doi       = {10.1002/anie.201703052},
  pages     = {10691 -- 10695},
  year      = {2017},
  abstract  = {In nature, proteins self-assemble into various structures with different dimensions. To construct these nanostructures in laboratories, normally proteins with different symmetries are selected. However, most of these approaches are engineering-intensive and highly dependent on the accuracy of the protein design. Herein, we report that a simple native protein LecA assembles into one-dimensional nanoribbons and nanowires, two-dimensional nanosheets, and three-dimensional layered structures controlled mainly by small-molecule assembly-inducing ligands RnG (n = 1, 2, 3, 4, 5) with varying numbers of ethylene oxide repeating units. To understand the formation mechanism of the different morphologies controlled by the small-molecule structure, molecular simulations were performed from microscopic and mesoscopic view, which presented a clear relationship between the molecular structure of the ligands and the assembled patterns. These results introduce an easy strategy to control the assembly structure and dimension, which could shed light on controlled protein assembly.},
  language  = {en}
}
@article{LuoChenZengetal.2018,
  author    = {Luo, Ting and Chen, Xiaoyi and Zeng, Shufei and Guan, Baozhang and Hu, Bo and Meng, Yu and Liu, Fanna and Wong, Taksui and Lu, Yongpin and Yun, Chen and Hocher, Berthold and Yin, Lianghong},
  title     = {Bioinformatic identification of key genes and analysis of prognostic values in clear cell renal cell carcinoma},
  series = {Oncology Letters},
  volume    = {16},
  journal   = {Oncology Letters},
  number    = {2},
  publisher = {Spandidos publ LTD},
  address   = {Athens},
  issn      = {1792-1074},
  doi       = {10.3892/ol.2018.8842},
  pages     = {1747 -- 1757},
  year      = {2018},
  abstract  = {The present study aimed to identify new key genes as potential biomarkers for the diagnosis, prognosis or targeted therapy of clear cell renal cell carcinoma (ccRCC). Three expression profiles (GSE36895, GSE46699 and GSE71963) were collected from Gene Expression Omnibus. GEO2R was used to identify differentially expressed genes (DEGs) in ccRCC tissues and normal samples. The Database for Annotation, Visualization and Integrated Discovery was utilized for functional and pathway enrichment analysis. STRING v10.5 and Molecular Complex Detection were used for protein-protein interaction (PPI) network construction and module analysis, respectively. Regulation network analyses were performed with the WebGestal tool. UALCAN web-portal was used for expression validation and survival analysis of hub genes in ccRCC patients from The Cancer Genome Atlas (TCGA). A total of 65 up- and 164 downregulated genes were identified as DEGs. DEGs were enriched with functional terms and pathways compactly related to ccRCC pathogenesis. Seventeen hub genes and one significant module were filtered out and selected from the PPI network. The differential expression of hub genes was verified in TCGA patients. Kaplan-Meier plot showed that high mRNA expression of enolase 2 (ENO2) was associated with short overall survival in ccRCC patients (P=0.023). High mRNA expression of cyclin D1 (CCND1) (P<0.001), fms related tyrosine kinase 1 (FLT1) (P=0.004), plasminogen (PLG) (P<0.001) and von Willebrand factor (VWF) (P=0.008) appeared to serve as favorable factors in survival. These findings indicate that the DEGs may be key genes in ccRCC pathogenesis and five genes, including ENO2, CCND1, PLT1, PLG and VWF, may serve as potential prognostic biomarkers in ccRCC.},
  language  = {en}
}
@article{WangHuangSachseetal.2016,
  author    = {Wang, Xinxin and Huang, Xianyu and Sachse, Dirk and Hu, Yu and Xue, Jiantao and Meyers, Philip A.},
  title     = {Comparisons of lipid molecular and carbon isotopic compositions in two particle-size fractions from surface peat and their implications for lipid preservation},
  series = {Environmental earth sciences},
  volume    = {75},
  journal   = {Environmental earth sciences},
  publisher = {Springer},
  address   = {New York},
  issn      = {1866-6280},
  doi       = {10.1007/s12665-016-5960-3},
  pages     = {375 -- 385},
  year      = {2016},
  abstract  = {Knowledge of the possible impacts of early diagenesis on lipid biomarkers in geologic settings is important for robust applications of lipid proxies for paleoclimate reconstructions. In this study, molecular distributions and carbon isotopic compositions of lipids were compared in two particle-size fractions (<0.3 mm and >0.3 mm) of twelve surface peat samples collected from Dajiuhu peatland, central China. The average chain length (ACL) values of long-chain n-alkanes, n-fatty alcohols, n-fatty acids and n-alkan-2-ones show no significant differences between the finer and coarser fractions. In contrast, the carbon preference index values of long-chain n-alkanes, n-fatty alcohols and n-alkan-2-ones have relatively smaller values in the finer fractions than in the coarser ones. Stanols were also more abundant in the finer fractions. In addition, the delta C-13 values of odd-numbered n-alkanes (C-23-C-33) were generally less negative in the finer fractions. Our results indicate that (1) the finer fractions probably experienced stronger degradation than the coarser fractions; (2) the less negative delta(CC)-C-13 values of odd-numbered n-alkanes (C-23-C-33) in the finer fractions were largely a result of greater heterotrophic reworking during degradation; (3) ACL values of long-chain n-alkyl lipids (n-alkanes, n-fatty alcohols and n-fatty acids, n-alkan-2-ones) appear to be reliable proxies to trace lipid sources and their associated paleoenvironmental signals in peat deposits.},
  language  = {en}
}
@article{SongLiNowaketal.2019,
  author    = {Song, Yu and Li, Gang and Nowak, Jacqueline and Zhang, Xiaoqing and Xu, Dongbei and Yang, Xiujuan and Huang, Guoqiang and Liang, Wanqi and Yang, Litao and Wang, Canhua and Bulone, Vincent and Nikoloski, Zoran and Hu, Jianping and Persson, Staffan and Zhang, Dabing},
  title     = {The Rice Actin-Binding Protein RMD Regulates Light-Dependent Shoot Gravitropism},
  series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
  volume    = {181},
  journal   = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
  number    = {2},
  publisher = {American Society of Plant Physiologists},
  address   = {Rockville},
  issn      = {0032-0889},
  doi       = {10.1104/pp.19.00497},
  pages     = {630 -- 644},
  year      = {2019},
  abstract  = {Light and gravity are two key determinants in orientating plant stems for proper growth and development. The organization and dynamics of the actin cytoskeleton are essential for cell biology and critically regulated by actin-binding proteins. However, the role of actin cytoskeleton in shoot negative gravitropism remains controversial. In this work, we report that the actin-binding protein Rice Morphology Determinant (RMD) promotes reorganization of the actin cytoskeleton in rice (Oryza sativa) shoots. The changes in actin organization are associated with the ability of the rice shoots to respond to negative gravitropism. Here, light-grown rmd mutant shoots exhibited agravitropic phenotypes. By contrast, etiolated rmd shoots displayed normal negative shoot gravitropism. Furthermore, we show that RMD maintains an actin configuration that promotes statolith mobility in gravisensing endodermal cells, and for proper auxin distribution in light-grown, but not dark-grown, shoots. RMD gene expression is diurnally controlled and directly repressed by the phytochrome-interacting factor-like protein OsPIL16. Consequently, overexpression of OsPIL16 led to gravisensing and actin patterning defects that phenocopied the rmd mutant. Our findings outline a mechanism that links light signaling and gravity perception for straight shoot growth in rice.},
  language  = {en}
}
@article{YangHuDingetal.2018,
  author    = {Yang, Guang and Hu, Rongting and Ding, Hong-ming and Kochovski, Zdravko and Mei, Shilin and Lu, Yan and Ma, Yu-qiang and Chen, Guosong and Jiang, Ming},
  title     = {CO2-switchable response of protein microtubules},
  series = {Materials chemistry frontiers},
  volume    = {2},
  journal   = {Materials chemistry frontiers},
  number    = {9},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2052-1537},
  doi       = {10.1039/c8qm00245b},
  pages     = {1642 -- 1646},
  year      = {2018},
  abstract  = {Recently, we proposed a small molecular inducing ligand strategy to assemble proteins into highly-ordered structures via dual non-covalent interactions, i.e. carbohydrate-protein interaction and dimerization of Rhodamine B. Using this approach, artificial protein microtubules were successfully constructed. In this study, we find that these microtubules exhibit a perfect CO2 responsiveness; assembly and disassembly of these microtubules were nicely controlled by the alternative passage of CO2 and N-2. Upon the injection of CO2, a negative net-charged SBA turns into a neutral or positive net-charged SBA, which elongated, to some extent, the effective distance between SBA and Rhodamine B, resulting in the disassociation of the Rhodamine B dimer. Further experimental and simulation results reveal that the CO2-responsive mechanism differs from that of solubility change of the previously reported CO2-responsive synthetic materials.},
  language  = {en}
}
@article{HuChengXuetal.2021,
  author    = {Hu, Ting-Li and Cheng, Feng and Xu, Zhen and Chen, Zhong-Zheng and Yu, Lei and Ban, Qian and Li, Chun-Lin and Pan, Tao and Zhang, Bao-Wei},
  title     = {Molecular and morphological evidence for a new species of the genus Typhlomys (Rodentia: Platacanthomyidae)},
  series = {Zoological research : ZR = Dongwuxue-yanjiu : jikan / published by Kunming Institute of Zoology, Chinese Academy of Sciences, Zhongguo Kexueyuan Kunming Dongwu Yanjiusuo zhuban, Dongwuxue-yanjiu Bianji Weiyuanhui bianji},
  volume    = {42},
  journal   = {Zoological research : ZR = Dongwuxue-yanjiu : jikan / published by Kunming Institute of Zoology, Chinese Academy of Sciences, Zhongguo Kexueyuan Kunming Dongwu Yanjiusuo zhuban, Dongwuxue-yanjiu Bianji Weiyuanhui bianji},
  number    = {1},
  publisher = {Yunnan Renmin Chubanshe},
  address   = {Kunming},
  issn      = {2095-8137},
  doi       = {10.24272/j.issn.2095-8137.2020.132},
  pages     = {100 -- 107},
  year      = {2021},
  abstract  = {In this study, we reassessed the taxonomic position of Typhlomys (Rodentia: Platacanthomyidae) from Huangshan, Anhui, China, based on morphological and molecular evidence. Results suggested that Typhlomys is comprised of up to six species, including four currently recognized species ( Typhlomys cinereus, T. chapensis, T. daloushanensis, and T. nanus), one unconfirmed candidate species, and one new species ( Typhlomys huangshanensis sp. nov.). Morphological analyses further supported the designation of the Huangshan specimens found at mid-elevations in the southern Huangshan Mountains (600 m to 1 200 m a.s.l.) as a new species.},
  language  = {en}
}