@article{MiddeldorpMahajanHorikoshietal.2019, author = {Middeldorp, Christel M. and Mahajan, Anubha and Horikoshi, Momoko and Robertson, Neil R. and Beaumont, Robin N. and Bradfield, Jonathan P. and Bustamante, Mariona and Cousminer, Diana L. and Day, Felix R. and De Silva, N. Maneka and Guxens, Monica and Mook-Kanamori, Dennis O. and St Pourcain, Beate and Warrington, Nicole M. and Adair, Linda S. and Ahlqvist, Emma and Ahluwalia, Tarunveer Singh and Almgren, Peter and Ang, Wei and Atalay, Mustafa and Auvinen, Juha and Bartels, Meike and Beckmann, Jacques S. and Bilbao, Jose Ramon and Bond, Tom and Borja, Judith B. and Cavadino, Alana and Charoen, Pimphen and Chen, Zhanghua and Coin, Lachlan and Cooper, Cyrus and Curtin, John A. and Custovic, Adnan and Das, Shikta and Davies, Gareth E. and Dedoussis, George V. and Duijts, Liesbeth and Eastwood, Peter R. and Eliasen, Anders U. and Elliott, Paul and Eriksson, Johan G. and Estivill, Xavier and Fadista, Joao and Fedko, Iryna O. and Frayling, Timothy M. and Gaillard, Romy and Gauderman, W. James and Geller, Frank and Gilliland, Frank and Gilsanz, Vincente and Granell, Raquel and Grarup, Niels and Groop, Leif and Hadley, Dexter and Hakonarson, Hakon and Hansen, Torben and Hartman, Catharina A. and Hattersley, Andrew T. and Hayes, M. Geoffrey and Hebebrand, Johannes and Heinrich, Joachim and Helgeland, Oyvind and Henders, Anjali K. and Henderson, John and Henriksen, Tine B. and Hirschhorn, Joel N. and Hivert, Marie-France and Hocher, Berthold and Holloway, John W. and Holt, Patrick and Hottenga, Jouke-Jan and Hypponen, Elina and Iniguez, Carmen and Johansson, Stefan and Jugessur, Astanand and Kahonen, Mika and Kalkwarf, Heidi J. and Kaprio, Jaakko and Karhunen, Ville and Kemp, John P. and Kerkhof, Marjan and Koppelman, Gerard H. and Korner, Antje and Kotecha, Sailesh and Kreiner-Moller, Eskil and Kulohoma, Benard and Kumar, Ashish and Kutalik, Zoltan and Lahti, Jari and Lappe, Joan M. and Larsson, Henrik and Lehtimaki, Terho and Lewin, Alexandra M. and Li, Jin and Lichtenstein, Paul and Lindgren, Cecilia M. and Lindi, Virpi and Linneberg, Allan and Liu, Xueping and Liu, Jun and Lowe, William L. and Lundstrom, Sebastian and Lyytikainen, Leo-Pekka and Ma, Ronald C. W. and Mace, Aurelien and Magi, Reedik and Magnus, Per and Mamun, Abdullah A. and Mannikko, Minna and Martin, Nicholas G. and Mbarek, Hamdi and McCarthy, Nina S. and Medland, Sarah E. and Melbye, Mads and Melen, Erik and Mohlke, Karen L. and Monnereau, Claire and Morgen, Camilla S. and Morris, Andrew P. and Murray, Jeffrey C. and Myhre, Ronny and Najman, Jackob M. and Nivard, Michel G. and Nohr, Ellen A. and Nolte, Ilja M. and Ntalla, Ioanna and Oberfield, Sharon E. and Oken, Emily and Oldehinkel, Albertine J. and Pahkala, Katja and Palviainen, Teemu and Panoutsopoulou, Kalliope and Pedersen, Oluf and Pennell, Craig E. and Pershagen, Goran and Pitkanen, Niina and Plomin, Robert and Power, Christine and Prasad, Rashmi B. and Prokopenko, Inga and Pulkkinen, Lea and Raikkonen, Katri and Raitakari, Olli T. and Reynolds, Rebecca M. and Richmond, Rebecca C. and Rivadeneira, Fernando and Rodriguez, Alina and Rose, Richard J. and Salem, Rany and Santa-Marina, Loreto and Saw, Seang-Mei and Schnurr, Theresia M. and Scott, James G. and Selzam, Saskia and Shepherd, John A. and Simpson, Angela and Skotte, Line and Sleiman, Patrick M. A. and Snieder, Harold and Sorensen, Thorkild I. A. and Standl, Marie and Steegers, Eric A. P. and Strachan, David P. and Straker, Leon and Strandberg, Timo and Taylor, Michelle and Teo, Yik-Ying and Thiering, Elisabeth and Torrent, Maties and Tyrrell, Jessica and Uitterlinden, Andre G. and van Beijsterveldt, Toos and van der Most, Peter J. and van Duijn, Cornelia M. and Viikari, Jorma and Vilor-Tejedor, Natalia and Vogelezang, Suzanne and Vonk, Judith M. and Vrijkotte, Tanja G. M. and Vuoksimaa, Eero and Wang, Carol A. and Watkins, William J. and Wichmann, H-Erich and Willemsen, Gonneke and Williams, Gail M. and Wilson, James F. and Wray, Naomi R. and Xu, Shujing and Xu, Cheng-Jian and Yaghootkar, Hanieh and Yi, Lu and Zafarmand, Mohammad Hadi and Zeggini, Eleftheria and Zemel, Babette S. and Hinney, Anke and Lakka, Timo A. and Whitehouse, Andrew J. O. and Sunyer, Jordi and Widen, Elisabeth E. and Feenstra, Bjarke and Sebert, Sylvain and Jacobsson, Bo and Njolstad, Pal R. and Stoltenberg, Camilla and Smith, George Davey and Lawlor, Debbie A. and Paternoster, Lavinia and Timpson, Nicholas J. and Ong, Ken K. and Bisgaard, Hans and Bonnelykke, Klaus and Jaddoe, Vincent W. V. and Tiemeier, Henning and Jarvelin, Marjo-Riitta and Evans, David M. and Perry, John R. B. and Grant, Struan F. A. and Boomsma, Dorret I. and Freathy, Rachel M. and McCarthy, Mark I. and Felix, Janine F.}, title = {The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia}, series = {European journal of epidemiology}, volume = {34}, journal = {European journal of epidemiology}, number = {3}, publisher = {Springer}, address = {Dordrecht}, organization = {EArly Genetics Lifecourse EGG Consortium EGG Membership EAGLE Membership}, issn = {0393-2990}, doi = {10.1007/s10654-019-00502-9}, pages = {279 -- 300}, year = {2019}, abstract = {The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.}, language = {en} } @article{ChipmanFerrierBrenaetal.2014, author = {Chipman, Ariel D. and Ferrier, David E. K. and Brena, Carlo and Qu, Jiaxin and Hughes, Daniel S. T. and Schroeder, Reinhard and Torres-Oliva, Montserrat and Znassi, Nadia and Jiang, Huaiyang and Almeida, Francisca C. and Alonso, Claudio R. and Apostolou, Zivkos and Aqrawi, Peshtewani and Arthur, Wallace and Barna, Jennifer C. J. and Blankenburg, Kerstin P. and Brites, Daniela and Capella-Gutierrez, Salvador and Coyle, Marcus and Dearden, Peter K. and Du Pasquier, Louis and Duncan, Elizabeth J. and Ebert, Dieter and Eibner, Cornelius and Erikson, Galina and Evans, Peter D. and Extavour, Cassandra G. and Francisco, Liezl and Gabaldon, Toni and Gillis, William J. and Goodwin-Horn, Elizabeth A. and Green, Jack E. and Griffiths-Jones, Sam and Grimmelikhuijzen, Cornelis J. P. and Gubbala, Sai and Guigo, Roderic and Han, Yi and Hauser, Frank and Havlak, Paul and Hayden, Luke and Helbing, Sophie and Holder, Michael and Hui, Jerome H. L. and Hunn, Julia P. and Hunnekuhl, Vera S. and Jackson, LaRonda and Javaid, Mehwish and Jhangiani, Shalini N. and Jiggins, Francis M. and Jones, Tamsin E. and Kaiser, Tobias S. and Kalra, Divya and Kenny, Nathan J. and Korchina, Viktoriya and Kovar, Christie L. and Kraus, F. Bernhard and Lapraz, Francois and Lee, Sandra L. and Lv, Jie and Mandapat, Christigale and Manning, Gerard and Mariotti, Marco and Mata, Robert and Mathew, Tittu and Neumann, Tobias and Newsham, Irene and Ngo, Dinh N. and Ninova, Maria and Okwuonu, Geoffrey and Ongeri, Fiona and Palmer, William J. and Patil, Shobha and Patraquim, Pedro and Pham, Christopher and Pu, Ling-Ling and Putman, Nicholas H. and Rabouille, Catherine and Ramos, Olivia Mendivil and Rhodes, Adelaide C. and Robertson, Helen E. and Robertson, Hugh M. and Ronshaugen, Matthew and Rozas, Julio and Saada, Nehad and Sanchez-Gracia, Alejandro and Scherer, Steven E. and Schurko, Andrew M. and Siggens, Kenneth W. and Simmons, DeNard and Stief, Anna and Stolle, Eckart and Telford, Maximilian J. and Tessmar-Raible, Kristin and Thornton, Rebecca and van der Zee, Maurijn and von Haeseler, Arndt and Williams, James M. and Willis, Judith H. and Wu, Yuanqing and Zou, Xiaoyan and Lawson, Daniel and Muzny, Donna M. and Worley, Kim C. and Gibbs, Richard A. and Akam, Michael and Richards, Stephen}, title = {The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima}, series = {PLoS biology}, volume = {12}, journal = {PLoS biology}, number = {11}, publisher = {PLoS}, address = {San Fransisco}, issn = {1545-7885}, doi = {10.1371/journal.pbio.1002005}, pages = {24}, year = {2014}, abstract = {Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.}, language = {en} } @article{deJongKukrejaTrabantetal.2013, author = {de Jong, S. and Kukreja, R. and Trabant, C. and Pontius, N. and Chang, C. F. and Kachel, T. and Beye, Martin and Sorgenfrei, Nomi and Back, C. H. and Braeuer, B. and Schlotter, W. F. and Turner, J. J. and Krupin, O. and Doehler, M. and Zhu, D. and Hossain, M. A. and Scherz, A. O. and Fausti, D. and Novelli, F. and Esposito, M. and Lee, W. S. and Chuang, Y. D. and Lu, D. H. and Moore, R. G. and Yi, M. and Trigo, M. and Kirchmann, P. and Pathey, L. and Golden, M. S. and Buchholz, Marcel and Metcalf, P. and Parmigiani, F. and Wurth, W. and F{\"o}hlisch, Alexander and Schuessler-Langeheine, Christian and Duerr, H. A.}, title = {Speed limit of the insulator-metal transition in magnetite}, series = {Nature materials}, volume = {12}, journal = {Nature materials}, number = {10}, publisher = {Nature Publ. Group}, address = {London}, issn = {1476-1122}, doi = {10.1038/NMAT3718}, pages = {882 -- 886}, year = {2013}, abstract = {As the oldest known magnetic material, magnetite (Fe3O4) has fascinated mankind for millennia. As the first oxide in which a relationship between electrical conductivity and fluctuating/localized electronic order was shown(1), magnetite represents a model system for understanding correlated oxides in general. Nevertheless, the exact mechanism of the insulator-metal, or Verwey, transition has long remained inaccessible(2-8). Recently, three- Fe- site lattice distortions called trimeronswere identified as the characteristic building blocks of the low-temperature insulating electronically ordered phase(9). Here we investigate the Verwey transition with pump- probe X- ray diffraction and optical reflectivity techniques, and show how trimerons become mobile across the insulator-metal transition. We find this to be a two- step process. After an initial 300 fs destruction of individual trimerons, phase separation occurs on a 1.5 +/- 0.2 ps timescale to yield residual insulating and metallic regions. This work establishes the speed limit for switching in future oxide electronics(10).}, language = {en} } @article{RoggeItagakiFishkinetal.2005, author = {Rogge, B. and Itagaki, Y. and Fishkin, N. and Levi, E. and Ruhl, R. and Yi, S. S. and Nakanishi, K. and Hammerling, U.}, title = {Retinoylserine and retinoylalanine, natural products of the moth Trichoplusia ni}, issn = {0163-3864}, year = {2005}, abstract = {Insect cells convert vitamin A into a number of retinoids that are evolutionarily conserved with those of mammalian cells. However, insect cells also produce additional natural retinoids. Namely, two retinoic acid peptides, N- trans-retinoylserine (1) and N-trans-retinoylalanine (2), have been isolated from a cell line of the common cabbage looper, Trichoplusia ni. These are the first examples of naturally occurring retinoic acid linked to amino acids through an amide bond; the amino acid moieties are depicted in the more common L-configuration, although the absolute configuration was not determined due to the minuscule sample amount}, language = {en} } @article{HsuSchmidtKempfetal.2018, author = {Hsu, Hsiang-Wen and Schmidt, J{\"u}rgen and Kempf, Sascha and Postberg, Frank and Moragas-Klostermeyer, Georg and Seiss, Martin and Hoffmann, Holger and Burton, Marcia and Ye, ShengYi and Kurth, William S. and Horanyi, Mihaly and Khawaja, Nozair and Spahn, Frank and Schirdewahn, Daniel and Moore, Luke and Cuzzi, Jeff and Jones, Geraint H. and Srama, Ralf}, title = {In situ collection of dust grains falling from Saturn's rings into its atmosphere}, series = {Science}, volume = {362}, journal = {Science}, number = {6410}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.aat3185}, pages = {49 -- +}, year = {2018}, abstract = {Saturn's main rings are composed of >95\% water ice, and the nature of the remaining few percent has remained unclear. The Cassini spacecraft's traversals between Saturn and its innermost D ring allowed its cosmic dust analyzer (CDA) to collect material released from the main rings and to characterize the ring material infall into Saturn. We report the direct in situ detection of material from Saturn's dense rings by the CDA impact mass spectrometer. Most detected grains are a few tens of nanometers in size and dynamically associated with the previously inferred "ring rain." Silicate and water-ice grains were identified, in proportions that vary with latitude. Silicate grains constitute up to 30\% of infalling grains, a higher percentage than the bulk silicate content of the rings.}, language = {en} } @article{KronerWildeO'Brienetal.2005, author = {Kroner, Alfred and Wilde, S. A. and O'Brien, Patrick J. and Li, J. H. and Passchier, C. W. and Walte, N. P. and Liu, Dun Yi}, title = {Field relationships, geochemistry, zircon ages and evolution of a late Archaean to Palaeoproterozoic lower crustal section in the Hengshan Terrain of northern China}, issn = {1000-9515}, year = {2005}, abstract = {The Hengshan complex forms part of the central zone of the North China Craton and consists predominantly of ductilely-deformed late Archaean to Palaeoproterozoic high-grade, partly migmatitic, granitoid orthogneisses, intruded by mafic dykes of gabbroic composition. Many highly strained rocks were previously misinterpreted as supracrustal sequences and represent mylonitized granitoids and sheared dykes. Our single zircon dating documents magmatic granitoid emplacement ages between 2.52 Ga and 2.48 Ga, with rare occurrences of 2.7 Ga gneisses, possibly reflecting an older basement. A few granitic gneisses have emplacement ages between 2.35 and 2.1 Ga and show the same structural features as the older rocks, indicating that the main deformation occurred after similar to 2.1 Ga. Intrusion of gabbroic dykes occurred at similar to 1920 Ma, and all Hengshan rocks underwent granulite-facies metamorphism at 1.88-1.85 Ga, followed by retrogression, shearing and uplift. We interpret the Hengshan and adjacent Fuping granitoid gneisses as the lower, plutonic, part of a late Archaean to early Palaeoproterozoic Japan-type magmatic arc, with the upper, volcanic part represented by the nearby Wutai complex. Components of this arc may have evolved at a continental margin as indicated by the 2.7 Ga zircons. Major deformation and HP metamorphism occurred in the late Palaeoproterozoic during the Luliang orogeny when the Eastern and Western blocks of the North China Craton collided to form the Trans-North China orogen. Shear zones in the Hengshan are interpreted as major lower crustal discontinuities post-dating the peak of HP metamorphism, and we suggest that they formed during orogenic collapse and uplift of the Hengshan complex in the late Palaeoproterozoic (< 1.85 Ga)}, language = {en} } @article{KroenerWildeZhaoetal.2006, author = {Kr{\"o}ner, Alfred and Wilde, Simon A. and Zhao, Guochun and O'Brien, Patrick J. and Sun, Min and Liu, Dun Yi and Wan, Yusheng and Liu, S. W. and Guo, Jianbin H.}, title = {Zircon geochronology and metamorphic evolution of mafic dykes in the Hengshan Complex of northern China: Evidence for late Palaeoproterozoic extension and subsequent high-pressure metamorphism in the North China Craton}, issn = {0301-9268}, doi = {10.1016/j.precamres.2006.01.008}, year = {2006}, abstract = {Magmatic and metamorphic zircons have been dated from ductilely deformed gabbroic dykes defining a dyke swarm and signifying crustal extension in the northern part of the Hengshan Complex of the North China Craton, These dykes now occur as boudins and deformed sheets within migmatitic tonalitic, trondhjemitic, granodioritic and granitic gneisses and are conspicuous due to relics of high-pressure granulite or even former eclogite facies garnet + pyroxene-bearing assemblages. SHRIMP ages for magmatic zircons from two dykes reflect the time of dyke emplacement at similar to 1915 Ma, whereas metamorphic zircons dated by both SHRIMP and evaporation techniques are consistently in the range 1848-1888 Ma. The Youngest granitoid gneiss yet dated in the Hengshan has an emplacement age of 18 2 17 Ma. These results complement recent geochronological studies from the neighbouring Wutai and Fuping Complexes, to the SE of the Hengshan, showing that a crustal extension event Occurred in the late Palaeoproterozoic. This preceded a major high-pressure collision- type metamorphic event in the central part of the North China Craton that occurred in the Palaeoproterozoic and not in the late Archaean as previously thought. Our data support recent suggestions that the North China Craton experienced a major, craton-wide orogenic event in the late Palaeoproterozoic after which it became cratonized and acted as a stable block.}, language = {en} }