@article{HoffmannWohltatMuelleretal.2017,
  author    = {Hoffmann, Stefan A. and Wohltat, Christian and M{\"u}ller, Kristian M. and Arndt, Katja Maren},
  title     = {A user-friendly, low-cost turbidostat with versatile growth rate estimation based on an extended Kalman filter},
  series = {PLoS one},
  volume    = {12},
  journal   = {PLoS one},
  number    = {7},
  publisher = {PLoS},
  address   = {Lawrence, Kan.},
  issn      = {1932-6203},
  doi       = {10.1371/JOURNAL.PONE.0181923},
  pages     = {1 -- 15},
  year      = {2017},
  abstract  = {For various experimental applications, microbial cultures at defined, constant densities are highly advantageous over simple batch cultures. Due to high costs, however, devices for continuous culture at freely defined densities still experience limited use. We have developed a small-scale turbidostat for research purposes, which is manufactured from inexpensive components and 3D printed parts. A high degree of spatial system integration and a graphical user interface provide user-friendly operability. The used optical density feedback control allows for constant continuous culture at a wide range of densities and offers to vary culture volume and dilution rates without additional parametrization. Further, a recursive algorithm for on-line growth rate estimation has been implemented. The employed Kalman filtering approach based on a very general state model retains the flexibility of the used control type and can be easily adapted to other bioreactor designs. Within several minutes it can converge to robust, accurate growth rate estimates. This is particularly useful for directed evolution experiments or studies on metabolic challenges, as it allows direct monitoring of the population fitness.},
  language  = {en}
}
@misc{HoffmannWohltatMuelleretal.2017,
  author    = {Hoffmann, Stefan A. and Wohltat, Christian and M{\"u}ller, Kristian M. and Arndt, Katja Maren},
  title     = {A user-friendly, low-cost turbidostat with versatile growth rate estimation based on an extended Kalman filter},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-403406},
  pages     = {15},
  year      = {2017},
  abstract  = {For various experimental applications, microbial cultures at defined, constant densities are highly advantageous over simple batch cultures. Due to high costs, however, devices for continuous culture at freely defined densities still experience limited use. We have developed a small-scale turbidostat for research purposes, which is manufactured from inexpensive components and 3D printed parts. A high degree of spatial system integration and a graphical user interface provide user-friendly operability. The used optical density feedback control allows for constant continuous culture at a wide range of densities and offers to vary culture volume and dilution rates without additional parametrization. Further, a recursive algorithm for on-line growth rate estimation has been implemented. The employed Kalman filtering approach based on a very general state model retains the flexibility of the used control type and can be easily adapted to other bioreactor designs. Within several minutes it can converge to robust, accurate growth rate estimates. This is particularly useful for directed evolution experiments or studies on metabolic challenges, as it allows direct monitoring of the population fitness.},
  language  = {en}
}
@article{HoffmannWohltatMuelleretal.2017,
  author    = {Hoffmann, Stefan A. and Wohltat, Christian and Mueller, Kristian M. and Arndt, Katja Maren},
  title     = {A user-friendly, low-cost turbidostat with versatile growth rate estimation based on an extended Kalman filter},
  series = {PLoS one},
  volume    = {12},
  journal   = {PLoS one},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0181923},
  pages     = {5944 -- 5952},
  year      = {2017},
  abstract  = {For various experimental applications, microbial cultures at defined, constant densities are highly advantageous over simple batch cultures. Due to high costs, however, devices for continuous culture at freely defined densities still experience limited use. We have developed a small-scale turbidostat for research purposes, which is manufactured from inexpensive components and 3D printed parts. A high degree of spatial system integration and a graphical user interface provide user-friendly operability. The used optical density feedback control allows for constant continuous culture at a wide range of densities and offers to vary culture volume and dilution rates without additional parametrization. Further, a recursive algorithm for on-line growth rate estimation has been implemented. The employed Kalman filtering approach based on a very general state model retains the flexibility of the used control type and can be easily adapted to other bioreactor designs. Within several minutes it can converge to robust, accurate growth rate estimates. This is particularly useful for directed evolution experiments or studies on metabolic challenges, as it allows direct monitoring of the population fitness.},
  language  = {en}
}
@article{OhlWohltatKliegletal.2016,
  author    = {Ohl, Sven and Wohltat, Christian and Kliegl, Reinhold and Pollatos, Olga and Engbert, Ralf},
  title     = {Microsaccades Are Coupled to Heartbeat},
  series = {The journal of neuroscience},
  volume    = {36},
  journal   = {The journal of neuroscience},
  publisher = {Society for Neuroscience},
  address   = {Washington},
  issn      = {0270-6474},
  doi       = {10.1523/JNEUROSCI.2211-15.2016},
  pages     = {1237 -- 1241},
  year      = {2016},
  abstract  = {During visual fixation, the eye generates microsaccades and slower components of fixational eye movements that are part of the visual processing strategy in humans. Here, we show that ongoing heartbeat is coupled to temporal rate variations in the generation of microsaccades. Using coregistration of eye recording and ECG in humans, we tested the hypothesis that microsaccade onsets are coupled to the relative phase of the R-R intervals in heartbeats. We observed significantly more microsaccades during the early phase after the R peak in the ECG. This form of coupling between heartbeat and eye movements was substantiated by the additional finding of a coupling between heart phase and motion activity in slow fixational eye movements; i.e., retinal image slip caused by physiological drift. Our findings therefore demonstrate a coupling of the oculomotor system and ongoing heartbeat, which provides further evidence for bodily influences on visuomotor functioning.},
  language  = {en}
}