@article{MelcherHartmannZopfetal.2011,
  author    = {Melcher, Ralph and Hartmann, Elena and Zopf, Waltraud and Herterich, Sabine and Wilke, Philipp and Mueller, Ludwig and Rosler, Eduard and Kudlich, Theodor and Al-Taie, Oliver and Rosenwald, Andreas and Katzenberger, Tiemo and Scholtka, Bettina and Seibold, Stefan and Rogoll, Dorothee and Scheppach, Wolfgang and Scheurlen, Michael and Luehrs, Hardi},
  title     = {LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability},
  series = {Carcinogenesis : a comprehensive survey},
  volume    = {32},
  journal   = {Carcinogenesis : a comprehensive survey},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0143-3334},
  doi       = {10.1093/carcin/bgr011},
  pages     = {636 -- 642},
  year      = {2011},
  abstract  = {Background and aims. Tumor suppressor genes are often located in frequently deleted chromosomal regions of colorectal cancers (CRCs). In contrast to microsatellite stable (MSS) tumors, only few loss of heterozygosity (LOH) studies were performed in microsatellite instable (MSI) tumors, because MSI carcinomas are generally considered to be chromosomally stable and classical LOH studies are not feasible due to MSI. The single nucleotide polymorphism (SNP) array technique enables LOH studies also in MSI CRC. The aim of our study was to analyse tissue from MSI and MSS CRC for the existence of (frequently) deleted chromosomal regions and tumor suppressor genes located therein. Methods and results. We analyzed tissues from 32 sporadic CRCs and their corresponding normal mucosa (16 MSS and 16 MSI tumors) by means of 50K SNP array analysis. MSS tumors displayed chromosomal instability that resulted in multiple deleted (LOH) and amplified regions and led to the identification of MTUS1 (8p22) as a candidate tumor suppressor gene in this region. Although the MSI tumors were chromosomally stable, we found several copy neutral LOHs (cnLOH) in the MSI tumors; these appear to be instrumental in the inactivation of the tumor suppressor gene hMLH1 and a gene located in chromosomal region 6pter-p22. Discussion. Our results suggest that in addition to classical LOH, cnLOH is an important mutational event in relation to the carcinogenesis of MSS and MSI tumors, causing the inactivation of a tumor suppressor gene without copy number alteration of the respective region; this is crucial for the development of MSI tumors and for some chromosomal regions in MSS tumors.},
  language  = {en}
}
@article{AnklamBehlerDingermannetal.2013,
  author    = {Anklam, Elke and Behler, J{\"o}rg and Dingermann, Theodor and Elsinghorst, Paul and Fischer, Jochen and Esselen, Melanie and Foerster, Christian and Fr{\"o}hlich, Daniel and Goedel, Werner Andreas and Gregory, Peter and Grimme, Stefan and Hackenberger, Christian and Hansmann, Max and Heppekausen, Johannes and Hasenstab-Riedel, Sebastian and Kirchhoff, Erhard and Kratz, Karl-Ludwig and Krausz, Ferenc and Linker, Torsten and List, Benjamin and Ray, Kallol and Salzer, Reiner and Schubert, Ulrich and Schueth, Ferdi and Schwarz, Helmut and Schwietzke, Uta and Strey, Reinhard and Stumpf, Thorsten and Vaagt, Franziska and Volodkin, Dmitry and Wilke, Guenther and Zass, Engelbert and Zemb, Thomas},
  title     = {Awards},
  series = {Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker},
  volume    = {61},
  journal   = {Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker},
  number    = {11},
  publisher = {Ges. Dt. Chemiker},
  address   = {Frankfurt, Main},
  issn      = {1439-9598},
  doi       = {10.1002/nadc.201390372},
  pages     = {1145 -- 1148},
  year      = {2013},
  language  = {de}
}
@article{SchmitzMoellerWilkeetal.2009,
  author    = {Schmitz, Sylvia and Moeller, Andreas and Wilke, Max and Malzer, Wolfgang and Kanngiesser, Birgit and Bousquet, Romain and Berger, Alfons and Schefer, Senecio},
  title     = {Chemical U-Th-Pb dating of monazite by 3D-Micro X-ray fluorescence analysis with synchrotron radiation},
  issn      = {0935-1221},
  doi       = {10.1127/0935-1221/2009/0021-1964},
  year      = {2009},
  abstract  = {A confocal set-up for three-dimensional (3D) micro X-ray fluorescence (micro-XRF) was used at the mySpot beamline at BESSY II, which allows compositional depth profiling for various applications. We present results obtained with a confocal 3D micro-XRF set-up for chemical age dating using the U, Th and Pb concentrations of monazite within rock thin sections. The probing volume was determined to be approximately 21 x 21 x 24 mu m(3) for W-L alpha using an excitation energy of 19 keV. The relative detection limits particularly for Pb are below 10 ppm (for Counting times},
  language  = {en}
}
@article{WilkeSchmidtZiemann2015,
  author    = {Wilke, Franziska Daniela Helena and Schmidt, Alexander and Ziemann, Martin Andreas},
  title     = {Subduction, peak and multi-stage exhumation metamorphism: Traces from one coesite-bearing eclogite, Tso Moran, western Himalaya},
  series = {Lithos : an international journal of mineralogy, petrology, and geochemistry},
  volume    = {231},
  journal   = {Lithos : an international journal of mineralogy, petrology, and geochemistry},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0024-4937},
  doi       = {10.1016/j.lithos2015.06.007},
  pages     = {77 -- 91},
  year      = {2015},
  abstract  = {Ultrahigh-pressure (UHP), coesite-bearing edogites in the Himalaya have been documented from the Kaghan Valley in Pakistan and the Tso Morani area in northwest India. These complexes are part of the northern edge of the Indian plate that has been subducted to, and metamorphosed at, mantle depths of more than 100 km before being exhumed. Both UHP complexes are located today directly adjacent to the Indus-Tsangpo suture zone and are not separated by non-metamorphosed sequences of Tethyan sediments from the Asian margin. Herein, we present new data for one fresh coesite-bearing eclogite from the Tso Moran massif. Therein, garnets are zoned reflecting their growth during prograde and peak metamorphism and showing a thin retrograde overgrowth. Inclusions can be directly correlated to the compositional zoning and are seen as either relicts of the protolith mineral paragenesis and as "snap shots" of the mineral paragenesis during subduction and under peak conditions. Rare earth element concentrations (REE) were obtained for garnet, mineral inclusions in garnet and matrix minerals. The REE pattern in garnet reflects a sequential change in matrix minerals and their proportions due to net transfer reactions during subduction and peak metamorphism. Using conventional geothermobarometry, a peak pressure of ca. 44-48 kbar at 560-760 degrees C followed by an S-shaped exhumation curve has been deduced. Gibbs free energy minimization modelling was used to supplement our analytical findings. (C) 2015 Elsevier B.V. All rights reserved.},
  language  = {en}
}
@article{OnckenLuschenMechieetal.1999,
  author    = {Oncken, Onno and Luschen, Ewald and Mechie, James and Sobolev, Stephan Vladimir and Schulze, Albrecht and Gaedicke, Christoph and Grunewald, Steffen and Bribach, Jens and Asch, G{\"u}nter and Giese, Peter and Wigger, Peter and Schmitz, Michael and Lueth, Stefan and Scheuber, Ekkehard and Haberland, Christian and Rietbrock, Andreas and G{\"o}tze, Hans-J{\"u}rgen and Brasse, Heinrich and Patzwahl, Regina and Chong, Guillermo and Wilke, Hans-Gerhard and Gonzalez, Gabriel and Jensen, Arturo and Araneda, Manuel and Vieytes, Hugo and Behn, Gerardo and Martinez, Eloy},
  title     = {Seismic reflection image revealing offset of Andean subduction-zone earthquake locations into oceanic mantle},
  year      = {1999},
  language  = {en}
}
@article{AlSa'diJaiserBagnichetal.2012,
  author    = {Al-Sa'di, Mahmoud and Jaiser, Frank and Bagnich, Sergey A. and Unger, Thomas and Blakesley, James C. and Wilke, Andreas and Neher, Dieter},
  title     = {Electrical and optical simulations of a polymer-based phosphorescent organic light-emitting diode with high efficiency},
  series = {Journal of polymer science : B, Polymer physics},
  volume    = {50},
  journal   = {Journal of polymer science : B, Polymer physics},
  number    = {22},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0887-6266},
  doi       = {10.1002/polb.23158},
  pages     = {1567 -- 1576},
  year      = {2012},
  abstract  = {A comprehensive numerical device simulation of the electrical and optical characteristics accompanied with experimental measurements of a new highly efficient system for polymer-based light-emitting diodes doped with phosphorescent dyes is presented. The system under investigation comprises an electron transporter attached to a polymer backbone blended with an electronically inert small molecule and an iridium-based green phosphorescent dye which serves as both emitter and hole transporter. The device simulation combines an electrical and an optical model. Based on the known highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels of all components as well as the measured electrical and optical characteristics of the devices, we model the emissive layer as an effective medium using the dye's HOMO as hole transport level and the polymer LUMO as electron transport level. By fine-tuning the injection barriers at the electron and hole-injecting contact, respectively, in simulated devices, unipolar device characteristics were fitted to the experimental data. Simulations using the so-obtained set of parameters yielded very good agreement to the measured currentvoltage, luminancevoltage characteristics, and the emission profile of entire bipolar light-emitting diodes, without additional fitting parameters. The simulation was used to gain insight into the physical processes and the mechanisms governing the efficiency of the organic light-emitting diode, including the position and extent of the recombination zone, carrier concentration profiles, and field distribution inside the device. The simulations show that the device is severely limited by hole injection, and that a reduction of the hole-injection barrier would improve the device efficiency by almost 50\%.},
  language  = {en}
}