@article{ScharfWeineltSchroederetal.2022,
  author    = {Scharf, Christina and Weinelt, Ferdinand Anton and Schroeder, Ines and Paal, Michael and Weigand, Michael and Zoller, Michael and Irlbeck, Michael and Kloft, Charlotte and Briegel, Josef and Liebchen, Uwe},
  title     = {Does the cytokine adsorber CytoSorb (R) reduce vancomycin exposure in critically ill patients with sepsis or septic shock?},
  series = {Annals of intensive care},
  volume    = {12},
  journal   = {Annals of intensive care},
  number    = {1},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {2110-5820},
  doi       = {10.1186/s13613-022-01017-5},
  pages     = {8},
  year      = {2022},
  abstract  = {Background: Hemadsorption of cytokines is used in critically ill patients with sepsis or septic shock. Concerns have been raised that the cytokine adsorber CytoSorb (R) unintentionally adsorbs vancomycin. This study aimed to quantify vancomycin elimination by CytoSorb (R) . Methods: Critically ill patients with sepsis or septic shock receiving continuous renal replacement therapy and CytoSorb (R) treatment during a prospective observational study were included in the analysis. Vancomycin pharmacokinetics was characterized using population pharmacokinetic modeling. Adsorption of vancomycin by the CytoSorb (R) was investigated as linear or saturable process. The final model was used to derive dosing recommendations based on stochastic simulations. Results: 20 CytoSorb (R) treatments in 7 patients (160 serum samples/24 during CytoSorb (R)-treatment, all continuous infusion) were included in the study. A classical one-compartment model, including effluent flow rate of the continuous hemodialysis as linear covariate on clearance, best described the measured concentrations (without CytoSorb (R)). Significant adsorption with a linear decrease during CytoSorb (R) treatment was identified (p <0.0001) and revealed a maximum increase in vancomycin clearance of 291\% (initially after CytoSorb (R) installation) and a maximum adsorption capacity of 572 mg. For a representative patient of our cohort a reduction of the area under the curve (AUC) by 93 mg/L*24 h during CytoSorb (R) treatment was observed. The additional administration of 500 mg vancomycin over 2 h during CytoSorb (R) attenuated the effect and revealed a negligible reduction of the AUC by 4 mg/L*24h. Conclusion: We recommend the infusion of 500 mg vancomycin over 2 h during CytoSorb (R) treatment to avoid subtherapeutic concentrations.},
  language  = {en}
}
@misc{CorbettSiegelThulinetal.2024,
  author    = {Corbett, Tim and Siegel, Bj{\"o}rn and Thulin, Mirjam and Cs{\´a}ky, Moritz and H{\"o}dl, Klaus and Kasper-Marienberg, Verena and Berkovich, Ilya and Czakai, Johannes and Maślak-Maciejewska, Alicja and Stechauner, Martin and Dodou, Lida-Maria and Heimann-Jelinek, Felicitas and Nasr, Omar T. and Halbinger, Monika and J{\´a}noš{\´i}kov{\´a}, Magdal{\´e}na and Keßler, Katrin and Kauders, Anthony D. and Piskačov{\´a}, Zora and Arnold, Rafael D. and Schulz, Michael K. and Shapira, Elena and Sidky, Sean and Sun, Cheuk Him Ryan and Tirosh-Samuelson, Hava and Tusan, Michelle and Weigand, Susanne},
  title     = {Intersections between Jewish Studies and Habsburg Studies},
  series = {PaRDeS : Journal of the Association for Jewish Studies in Germany},
  journal   = {PaRDeS : Journal of the Association for Jewish Studies in Germany},
  number    = {29},
  editor    = {Siegel, Bj{\"o}rn and Thulin, Mirjam and Corbett, Tim},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-62207},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-622072},
  pages     = {202},
  year      = {2024},
  abstract  = {In the aftermath of the Shoah and the ostensible triumph of nationalism, it became common in historiography to relegate Jews to the position of the "eternal other" in a series of binaries: Christian/Jewish, Gentile/Jewish, European/Jewish, non-Jewish/Jewish, and so forth. For the longest time, these binaries remained characteristic of Jewish historiography, including in the Central European context. Assuming instead, as the more recent approaches in Habsburg studies do, that pluriculturalism was the basis of common experience in formerly Habsburg Central Europe, and accepting that no single "majority culture" existed, but rather hegemonies were imposed in certain contexts, then the often used binaries are misleading and conceal the complex and sometimes even paradoxical conditions that shaped Jewish life in the region before the Shoah. The very complexity of Habsburg Central Europe both in synchronic and diachronic perspective precludes any singular historical narrative of "Habsburg Jewry," and it is not the intention of this volume to offer an overview of "Habsburg Jewish history." The selected articles in this volume illustrate instead how important it is to reevaluate categories, deconstruct historical narratives, and reconceptualize implemented approaches in specific geographic, temporal, and cultural contexts in order to gain a better understanding of the complex and pluricultural history of the Habsburg Empire and the region as a whole.},
  language  = {en}
}