@article{WuttkeLiLietal.2019,
  author    = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian},
  title     = {A catalog of genetic loci associated with kidney function from analyses of a million individuals},
  series = {Nature genetics},
  volume    = {51},
  journal   = {Nature genetics},
  number    = {6},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {Lifelines COHort Study},
  issn      = {1061-4036},
  doi       = {10.1038/s41588-019-0407-x},
  pages     = {957 -- +},
  year      = {2019},
  abstract  = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.},
  language  = {en}
}
@article{AbdoAckermannAjelloetal.2011,
  author    = {Abdo, A. A. and Ackermann, Margit and Ajello, M. and Allafort, A. J. and Baldini, L. and Ballet, J. and Barbiellini, G. and Baring, M. G. and Bastieri, D. and Bechtol, K. C. and Bellazzini, R. and Berenji, B. and Blandford, R. D. and Bloom, E. D. and Bonamente, E. and Borgland, A. W. and Bouvier, A. and Brandt, T. J. and Bregeon, Johan and Brez, A. and Brigida, M. and Bruel, P. and Buehler, R. and Buson, S. and Caliandro, G. A. and Cameron, R. A. and Cannon, A. and Caraveo, P. A. and Carrigan, Svenja and Casandjian, J. M. and Cavazzuti, E. and Cecchi, C. and Celik, O. and Charles, E. and Chekhtman, A. and Cheung, C. C. and Chiang, J. and Ciprini, S. and Claus, R. and Cohen-Tanugi, J. and Conrad, Jan and Cutini, S. and Dermer, C. D. and de Palma, F. and do Couto e Silva, E. and Drell, P. S. and Dubois, R. and Dumora, D. and Favuzzi, C. and Fegan, S. J. and Ferrara, E. C. and Focke, W. B. and Fortin, P. and Frailis, M. and Fuhrmann, L. and Fukazawa, Y. and Funk, S. and Fusco, P. and Gargano, F. and Gasparrini, D. and Gehrels, N. and Germani, S. and Giglietto, N. and Giordano, F. and Giroletti, M. and Glanzman, T. and Godfrey, G. and Grenier, I. A. and Guillemot, L. and Guiriec, S. and Hayashida, M. and Hays, E. and Horan, D. and Hughes, R. E. and Johannesson, G. and Johnson, A. S. and Johnson, W. N. and Kadler, M. and Kamae, T. and Katagiri, H. and Kataoka, J. and Knoedlseder, J. and Kuss, M. and Lande, J. and Latronico, L. and Lee, S. -H. and Lemoine-Goumard, M. and Longo, F. and Loparco, F. and Lott, B. and Lovellette, M. N. and Lubrano, P. and Madejski, G. M. and Makeev, A. and Max-Moerbeck, W. and Mazziotta, Mario Nicola and McEnery, J. E. and Mehault, J. and Michelson, P. F. and Mitthumsiri, W. and Mizuno, T. and Moiseev, A. A. and Monte, C. and Monzani, M. E. and Morselli, A. and Moskalenko, I. V. and Murgia, S. and Naumann-Godo, M. and Nishino, S. and Nolan, P. L. and Norris, J. P. and Nuss, E. and Ohsugi, T. and Okumura, A. and Omodei, N. and Orlando, E. and Ormes, J. F. and Paneque, D. and Panetta, J. H. and Parent, D. and Pavlidou, V. and Pearson, T. J. and Pelassa, V. and Pepe, M. and Pesce-Rollins, M. and Piron, F. and Porter, T. A. and Raino, S. and Rando, R. and Razzano, M. and Readhead, A. and Reimer, A. and Reimer, O. and Richards, J. L. and Ripken, J. and Ritz, S. and Roth, M. and Sadrozinski, H. F. -W. and Sanchez, D. and Sander, A. and Scargle, J. D. and Sgro, C. and Siskind, E. J. and Smith, P. D. and Spandre, G. and Spinelli, P. and Stawarz, L. and Stevenson, M. and Strickman, M. S. and Sokolovsky, K. V. and Suson, D. J. and Takahashi, H. and Takahashi, T. and Tanaka, T. and Thayer, J. B. and Thayer, J. G. and Thompson, D. J. and Tibaldo, L. and Torres, F. and Tosti, G. and Tramacere, A. and Uchiyama, Y. and Usher, T. L. and Vandenbroucke, J. and Vasileiou, V. and Vilchez, N. and Vitale, V. and Waite, A. P. and Wang, P. and Wehrle, A. E. and Winer, B. L. and Wood, K. S. and Yang, Z. and Ylinen, T. and Zensus, J. A. and Ziegler, M. and Aleksic, J. and Antonelli, L. A. and Antoranz, P. and Backes, Michael and Barrio, J. A. and Gonzalez, J. Becerra and Bednarek, W. and Berdyugin, A. and Berger, K. and Bernardini, E. and Biland, A. and Blanch Bigas, O. and Bock, R. K. and Boller, A. and Bonnoli, G. and Bordas, Pol and Tridon, D. Borla and Bosch-Ramon, Valentin and Bose, D. and Braun, I. and Bretz, T. and Camara, M. and Carmona, E. and Carosi, A. and Colin, P. and Colombo, E. and Contreras, J. L. and Cortina, J. and Covino, S. and Dazzi, F. and de Angelis, A. and del Pozo, E. De Cea and De Lotto, B. and De Maria, M. and De Sabata, F. and Mendez, C. Delgado and Ortega, A. Diago and Doert, M. and Dominguez, A. and Prester, Dijana Dominis and Dorner, D. and Doro, M. and Elsaesser, D. and Ferenc, D. and Fonseca, M. V. and Font, L. and Lopen, R. J. Garcia and Garczarczyk, M. and Gaug, M. and Giavitto, G. and Godinovi, N. and Hadasch, D. and Herrero, A. and Hildebrand, D. and Hoehne-Moench, D. and Hose, J. and Hrupec, D. and Jogler, T. and Klepser, S. and Kraehenbuehl, T. and Kranich, D. and Krause, J. and La Barbera, A. and Leonardo, E. and Lindfors, E. and Lombardi, S. and Lopez, M. and Lorenz, E. and Majumdar, P. and Makariev, E. and Maneva, G. and Mankuzhiyil, N. and Mannheim, K. and Maraschi, L. and Mariotti, M. and Martinez, M. and Mazin, D. and Meucci, M. and Miranda, J. M. and Mirzoyan, R. and Miyamoto, H. and Moldon, J. and Moralejo, A. and Nieto, D. and Nilsson, K. and Orito, R. and Oya, I. and Paoletti, R. and Paredes, J. M. and Partini, S. and Pasanen, M. and Pauss, F. and Pegna, R. G. and Perez-Torres, M. A. and Persic, M. and Peruzzo, J. and Pochon, J. and Moroni, P. G. Prada and Prada, F. and Prandini, E. and Puchades, N. and Puljak, I. and Reichardt, T. and Reinthal, R. and Rhode, W. and Ribo, M. and Rico, J. and Rissi, M. and Ruegamer, S. and Saggion, A. and Saito, K. and Saito, T. Y. and Salvati, M. and Sanchez-Conde, M. and Satalecka, K. and Scalzotto, V. and Scapin, V. and Schultz, C. and Schweizer, T. and Shayduk, M. and Shore, S. N. and Sierpowska-Bartosik, A. and Sillanpaa, A. and Sitarek, J. and Sobczynska, D. and Spanier, F. and Spiro, S. and Stamerra, A. and Steinke, B. and Storz, J. and Strah, N. and Struebig, J. C. and Suric, T. and Takalo, L. O. and Tavecchio, F. and Temnikov, P. and Terzic, T. and Tescaro, D. and Teshima, M. and Vankov, H. and Wagner, R. M. and Weitzel, Q. and Zabalza, V. and Zandanel, F. and Zanin, R. and Acciari, V. A. and Arlen, T. and Aune, T. and Benbow, W. and Boltuch, D. and Bradbury, S. M. and Buckley, J. H. and Bugaev, V. and Cannon, A. and Cesarini, A. and Ciupik, L. and Cui, W. and Dickherber, R. and Errando, M. and Falcone, A. and Finley, J. P. and Finnegan, G. and Fortson, L. and Furniss, A. and Galante, N. and Gall, D. and Gillanders, G. H. and Godambe, S. and Grube, J. and Guenette, R. and Gyuk, G. and Hanna, D. and Holder, J. and Huang, D. and Hui, C. M. and Humensky, T. B. and Kaaret, P. and Karlsson, N. and Kertzman, M. and Kieda, D. and Konopelko, A. and Krawczynski, H. and Krennrich, F. and Lang, M. J. and Maier, G. and McArthur, S. and McCann, A. and McCutcheon, M. and Moriarty, P. and Mukherjee, R. and Ong, R. and Otte, N. and Pandel, D. and Perkins, J. S. and Pichel, A. and Pohl, M. and Quinn, J. and Ragan, K. and Reyes, L. C. and Reynolds, P. T. and Roache, E. and Rose, H. J. and Rovero, A. C. and Schroedter, M. and Sembroski, G. H. and Senturk, G. D. and Steele, D. and Swordy, S. P. and Tesic, G. and Theiling, M. and Thibadeau, S. and Varlotta, A. and Vincent, S. and Wakely, S. P. and Ward, J. E. and Weekes, T. C. and Weinstein, A. and Weisgarber, T. and Williams, D. A. and Wood, M. and Zitzer, B. and Villata, M. and Raiteri, C. M. and Aller, H. D. and Aller, M. F. and Arkharov, A. A. and Blinov, D. A. and Calcidese, P. and Chen, W. P. and Efimova, N. V. and Kimeridze, G. and Konstantinova, T. S. and Kopatskaya, E. N. and Koptelova, E. and Kurtanidze, O. M. and Kurtanidze, S. O. and Lahteenmaki, A. and Larionov, V. M. and Larionova, E. G. and Larionova, L. V. and Ligustri, R. and Morozova, D. A. and Nikolashvili, M. G. and Sigua, L. A. and Troitsky, I. S. and Angelakis, E. and Capalbi, M. and Carraminana, A. and Carrasco, L. and Cassaro, P. and de la Fuente, E. and Gurwell, M. A. and Kovalev, Y. Y. and Kovalev, Yu. A. and Krichbaum, T. P. and Krimm, H. A. and Leto, Paolo and Lister, M. L. and Maccaferri, G. and Moody, J. W. and Mori, Y. and Nestoras, I. and Orlati, A. and Pagani, C. and Pace, C. and Pearson, R. and Perri, M. and Piner, B. G. and Pushkarev, A. B. and Ros, E. and Sadun, A. C. and Sakamoto, T. and Tornikoski, M. and Yatsu, Y. and Zook, A.},
  title     = {Insights into the high-energy gamma-Ray emission of markarian 501 fromextensive multifrequency observations in the fermi era},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {727},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {2},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  organization    = {Fermi-LAT Collaboration, MAGIC Collaboration, VERITAS Collaboration},
  issn      = {0004-637X},
  doi       = {10.1088/0004-637X/727/2/129},
  pages     = {26},
  year      = {2011},
  abstract  = {We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.},
  language  = {en}
}
@article{AckermannAjelloAllafortetal.2011,
  author    = {Ackermann, Margit and Ajello, M. and Allafort, A. J. and Baldini, L. and Ballet, J. and Barbiellini, G. and Bastieri, D. and Belfiore, A. and Bellazzini, R. and Berenji, B. and Blandford, R. D. and Bloom, E. D. and Bonamente, E. and Borgland, A. W. and Bottacini, E. and Brigida, M. and Bruel, P. and Buehler, R. and Buson, S. and Caliandro, G. A. and Cameron, R. A. and Caraveo, P. A. and Casandjian, J. M. and Cecchi, C. and Chekhtman, A. and Cheung, C. C. and Chiang, J. and Ciprini, S. and Claus, R. and Cohen-Tanugi, J. and de Angelis, A. and de Palma, F. and Dermer, C. D. and do Couto e Silva, E. and Drell, P. S. and Dumora, D. and Favuzzi, C. and Fegan, S. J. and Focke, W. B. and Fortin, P. and Fukazawa, Y. and Fusco, P. and Gargano, F. and Germani, S. and Giglietto, N. and Giordano, F. and Giroletti, M. and Glanzman, T. and Godfrey, G. and Grenier, I. A. and Guillemot, L. and Guiriec, S. and Hadasch, D. and Hanabata, Y. and Harding, A. K. and Hayashida, M. and Hayashi, K. and Hays, E. and Johannesson, G. and Johnson, A. S. and Kamae, T. and Katagiri, H. and Kataoka, J. and Kerr, M. and Knoedlseder, J. and Kuss, M. and Lande, J. and Latronico, L. and Lee, S. -H. and Longo, F. and Loparco, F. and Lott, B. and Lovellette, M. N. and Lubrano, P. and Martin, P. and Mazziotta, Mario Nicola and McEnery, J. E. and Mehault, J. and Michelson, P. F. and Mitthumsiri, W. and Mizuno, T. and Monte, C. and Monzani, M. E. and Morselli, A. and Moskalenko, I. V. and Murgia, S. and Naumann-Godo, M. and Nolan, P. L. and Norris, J. P. and Nuss, E. and Ohsugi, T. and Okumura, A. and Orlando, E. and Ormes, J. F. and Ozaki, M. and Paneque, D. and Parent, D. and Pesce-Rollins, M. and Pierbattista, M. and Piron, F. and Pohl, Martin and Prokhorov, D. and Raino, S. and Rando, R. and Razzano, M. and Reposeur, T. and Ritz, S. and Parkinson, P. M. Saz and Sgro, C. and Siskind, E. J. and Smith, P. D. and Spinelli, P. and Strong, A. W. and Takahashi, H. and Tanaka, T. and Thayer, J. G. and Thayer, J. B. and Thompson, D. J. and Tibaldo, L. and Torres, D. F. and Tosti, G. and Tramacere, A. and Troja, E. and Uchiyama, Y. and Vandenbroucke, J. and Vasileiou, V. and Vianello, G. and Vitale, V. and Waite, A. P. and Wang, P. and Winer, B. L. and Wood, K. S. and Yang, Z. and Zimmer, S. and Bontemps, S.},
  title     = {A cocoon of freshly accelerated cosmic rays detected by fermi in the cygnus superbubble},
  series = {Science},
  volume    = {334},
  journal   = {Science},
  number    = {6059},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {0036-8075},
  doi       = {10.1126/science.1210311},
  pages     = {1103 -- 1107},
  year      = {2011},
  abstract  = {The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.},
  language  = {en}
}
@article{AbdoAckermannAjelloetal.2011,
  author    = {Abdo, A. A. and Ackermann, Margit and Ajello, M. and Allafort, A. J. and Baldini, L. and Ballet, J. and Barbiellini, G. and Baring, M. G. and Bastieri, D. and Bellazzini, R. and Berenji, B. and Blandford, R. D. and Bloom, E. D. and Bonamente, E. and Borgland, A. W. and Bouvier, A. and Brandt, T. J. and Bregeon, Johan and Brigida, M. and Bruel, P. and Buehler, R. and Buson, S. and Caliandro, G. A. and Cameron, R. A. and Caraveo, P. A. and Casandjian, J. M. and Cecchi, C. and Chaty, S. and Chekhtman, A. and Cheung, C. C. and Chiang, J. and Cillis, A. N. and Ciprini, S. and Claus, R. and Cohen-Tanugi, J. and Conrad, Jan and Corbel, S. and Cutini, S. and de Angelis, A. and de Palma, F. and Dermer, C. D. and Digel, S. W. and do Couto e Silva, E. and Drell, P. S. and Drlica-Wagner, A. and Dubois, R. and Dumora, D. and Favuzzi, C. and Ferrara, E. C. and Fortin, P. and Frailis, M. and Fukazawa, Y. and Fukui, Y. and Funk, S. and Fusco, P. and Gargano, F. and Gasparrini, D. and Gehrels, N. and Germani, S. and Giglietto, N. and Giordano, F. and Giroletti, M. and Glanzman, T. and Godfrey, G. and Grenier, I. A. and Grondin, M. -H. and Guiriec, S. and Hadasch, D. and Hanabata, Y. and Harding, A. K. and Hayashida, M. and Hayashi, K. and Hays, E. and Horan, D. and Jackson, M. S. and Johannesson, G. and Johnson, A. S. and Kamae, T. and Katagiri, H. and Kataoka, J. and Kerr, M. and Knoedlseder, J. and Kuss, M. and Lande, J. and Latronico, L. and Lee, S. -H. and Lemoine-Goumard, M. and Longo, F. and Loparco, F. and Lovellette, M. N. and Lubrano, P. and Madejski, G. M. and Makeev, A. and Mazziotta, Mario Nicola and McEnery, J. E. and Michelson, P. F. and Mignani, R. P. and Mitthumsiri, W. and Mizuno, T. and Moiseev, A. A. and Monte, C. and Monzani, M. E. and Morselli, A. and Moskalenko, I. V. and Murgia, S. and Naumann-Godo, M. and Nolan, P. L. and Norris, J. P. and Nuss, E. and Ohsugi, T. and Okumura, A. and Orlando, E. and Ormes, J. F. and Paneque, D. and Parent, D. and Pelassa, V. and Pesce-Rollins, M. and Pierbattista, M. and Piron, F. and Pohl, Martin and Porter, T. A. and Raino, S. and Rando, R. and Razzano, M. and Reimer, O. and Reposeur, T. and Ritz, S. and Romani, R. W. and Roth, M. and Sadrozinski, H. F. -W. and Parkinson, P. M. Saz and Sgro, C. and Smith, D. A. and Smith, P. D. and Spandre, G. and Spinelli, P. and Strickman, M. S. and Tajima, H. and Takahashi, H. and Takahashi, T. and Tanaka, T. and Thayer, J. G. and Thayer, J. B. and Thompson, D. J. and Tibaldo, L. and Tibolla, O. and Torres, D. F. and Tosti, G. and Tramacere, A. and Troja, E. and Uchiyama, Y. and Vandenbroucke, J. and Vasileiou, V. and Vianello, G. and Vilchez, N. and Vitale, V. and Waite, A. P. and Wang, P. and Winer, B. L. and Wood, K. S. and Yamamoto, H. and Yamazaki, R. and Yang, Z. and Ziegler, M.},
  title     = {Observations of the young supernova remnant RX J1713.7-3946 with the fermi large area telescope},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {734},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {1},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {0004-637X},
  doi       = {10.1088/0004-637X/734/1/28},
  pages     = {9},
  year      = {2011},
  abstract  = {We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0 degrees.55 +/- 0 degrees.04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Gamma = 1.5 +/- 0.1 that coincides in normalization with the steeper H. E. S. S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.},
  language  = {en}
}
@article{DeAngelisTatischeffGrenieretal.2018,
  author    = {De Angelis, A. and Tatischeff, V. and Grenier, I. A. and McEnery, J. and Mallamaci, Manuela and Tavani, M. and Oberlack, U. and Hanlon, L. and Walter, R. and Argan, A. and Von Ballmoos, P. and Bulgarelli, A. and Bykov, A. and Hernanz, M. and Kanbach, G. and Kuvvetli, I. and Pearce, M. and Zdziarski, A. and Conrad, J. and Ghisellini, G. and Harding, A. and Isern, J. and Leising, M. and Longo, F. and Madejski, G. and Martinez, M. and Mazziotta, Mario Nicola and Paredes, J. M. and Pohl, Martin and Rando, R. and Razzano, M. and Aboudan, A. and Ackermann, M. and Addazi, A. and Ajello, M. and Albertus, C. and Alvarez, J. M. and Ambrosi, G. and Anton, S. and Antonelli, L. A. and Babic, A. and Baibussinov, B. and Balbom, M. and Baldini, L. and Balman, S. and Bambi, C. and Barres de Almeida, U. and Barrio, J. A. and Bartels, R. and Bastieri, D. and Bednarek, W. and Bernard, D. and Bernardini, E. and Bernasconi, T. and Bertucci, B. and Biland, A. and Bissaldi, E. and Boettcher, M. and Bonvicini, V. and Bosch-Ramon, V. and Bottacini, E. and Bozhilov, V. and Bretz, T. and Branchesi, M. and Brdar, V. and Bringmann, T. and Brogna, A. and Jorgensen, C. Budtz and Busetto, G. and Buson, S. and Busso, M. and Caccianiga, A. and Camera, S. and Campana, R. and Caraveo, P. and Cardillo, M. and Carlson, P. and Celestin, S. and Cermeno, M. and Chen, A. and Cheung, C. C. and Churazov, E. and Ciprini, S. and Coc, A. and Colafrancesco, S. and Coleiro, A. and Collmar, W. and Coppi, P. and Curado da Silva, R. and Cutini, S. and De Lotto, B. and de Martino, D. and De Rosa, A. and Del Santo, M. and Delgado, L. and Diehl, R. and Dietrich, S. and Dolgov, A. D. and Dominguez, A. and Prester, D. Dominis and Donnarumma, I. and Dorner, D. and Doro, M. and Dutra, M. and Elsaesser, D. and Fabrizio, M. and Fernandez-Barral, A. and Fioretti, V. and Foffano, L. and Formato, V. and Fornengo, N. and Foschini, L. and Franceschini, A. and Franckowiak, A. and Funk, S. and Fuschino, F. and Gaggero, D. and Galanti, G. and Gargano, F. and Gasparrini, D. and Gehrz, R. and Giammaria, P. and Giglietto, N. and Giommi, P. and Giordano, F. and Giroletti, M. and Ghirlanda, G. and Godinovic, N. and Gouiffes, C. and Grove, J. E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Hryczuk, A. and Jean, P. and Johnson, T. and Jose, J. and Kaufmann, S. and Khelifi, B. and Kiener, J. and Knodlseder, J. and Kolem, M. and Kopp, J. and Kozhuharov, V. and Labanti, C. and Lalkovski, S. and Laurent, P. and Limousin, O. and Linares, M. and Lindfors, E. and Lindner, M. and Liu, J. and Lombardi, S. and Loparco, F. and Lopez-Coto, R. and Lopez Moya, M. and Lott, B. and Lubrano, P. and Malyshev, D. and Mankuzhiyil, N. and Mannheim, K. and Marcha, M. J. and Marciano, A. and Marcote, B. and Mariotti, M. and Marisaldi, M. and McBreen, S. and Mereghetti, S. and Merle, A. and Mignani, R. and Minervini, G. and Moiseev, A. and Morselli, A. and Moura, F. and Nakazawa, K. and Nava, L. and Nieto, D. and Orienti, M. and Orio, M. and Orlando, E. and Orleanski, P. and Paiano, S. and Paoletti, R. and Papitto, A. and Pasquato, M. and Patricelli, B. and Perez-Garcia, M. A. and Persic, M. and Piano, G. and Pichel, A. and Pimenta, M. and Pittori, C. and Porter, T. and Poutanen, J. and Prandini, E. and Prantzos, N. and Produit, N. and Profumo, S. and Queiroz, F. S. and Raino, S. and Raklev, A. and Regis, M. and Reichardt, I. and Rephaeli, Y. and Rico, J. and Rodejohann, W. and Fernandez, G. Rodriguez and Roncadelli, M. and Roso, L. and Rovero, A. and Ruffini, R. and Sala, G. and Sanchez-Conde, M. A. and Santangelo, Andrea and Parkinson, P. Saz and Sbarrato, T. and Shearer, A. and Shellard, R. and Short, K. and Siegert, T. and Siqueira, C. and Spinelli, P. and Stamerra, A. and Starrfield, S. and Strong, A. and Strumke, I. and Tavecchio, F. and Taverna, R. and Terzic, T. and Thompson, D. J. and Tibolla, O. and Torres, D. F. and Turolla, R. and Ulyanov, A. and Ursi, A. and Vacchi, A. and Van den Abeele, J. and Vankova-Kirilovai, G. and Venter, C. and Verrecchia, F. and Vincent, P. and Wang, X. and Weniger, C. and Wu, X. and Zaharijas, G. and Zampieri, L. and Zane, S. and Zimmer, S. and Zoglauer, A.},
  title     = {Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics},
  series = {Journal of High Energy Astrophysics},
  volume    = {19},
  journal   = {Journal of High Energy Astrophysics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  organization    = {e-ASTROGAM Collaboration},
  issn      = {2214-4048},
  doi       = {10.1016/j.jheap.2018.07.001},
  pages     = {1 -- 106},
  year      = {2018},
  language  = {en}
}
@article{WarringtonBeaumontHorikoshietal.2019,
  author    = {Warrington, Nicole and Beaumont, Robin and Horikoshi, Momoko and Day, Felix R. and Helgeland, {\O}yvind and Laurin, Charles and Bacelis, Jonas and Peng, Shouneng and Hao, Ke and Feenstra, Bjarke and Wood, Andrew R. and Mahajan, Anubha and Tyrrell, Jessica and Robertson, Neil R. and Rayner, N. William and Qiao, Zhen and Moen, Gunn-Helen and Vaudel, Marc and Marsit, Carmen and Chen, Jia and Nodzenski, Michael and Schnurr, Theresia M. and Zafarmand, Mohammad Hadi and Bradfield, Jonathan P. and Grarup, Niels and Kooijman, Marjolein N. and Li-Gao, Ruifang and Geller, Frank and Ahluwalia, Tarunveer Singh and Paternoster, Lavinia and Rueedi, Rico and Huikari, Ville and Hottenga, Jouke-Jan and Lyytik{\"a}inen, Leo-Pekka and Cavadino, Alana and Metrustry, Sarah and Cousminer, Diana L. and Wu, Ying and Thiering, Elisabeth Paula and Wang, Carol A. and Have, Christian Theil and Vilor-Tejedor, Natalia and Joshi, Peter K. and Painter, Jodie N. and Ntalla, Ioanna and Myhre, Ronny and Pitk{\"a}nen, Niina and van Leeuwen, Elisabeth M. and Joro, Raimo and Lagou, Vasiliki and Richmond, Rebecca C. and Espinosa, Ana and Barton, Sheila J. and Inskip, Hazel M. and Holloway, John W. and Santa-Marina, Loreto and Estivill, Xavier and Ang, Wei and Marsh, Julie A. and Reichetzeder, Christoph and Marullo, Letizia and Hocher, Berthold and Lunetta, Kathryn L. and Murabito, Joanne M. and Relton, Caroline L. and Kogevinas, Manolis and Chatzi, Leda and Allard, Catherine and Bouchard, Luigi and Hivert, Marie-France and Zhang, Ge and Muglia, Louis J. and Heikkinen, Jani and Morgen, Camilla S. and van Kampen, Antoine H. C. and van Schaik, Barbera D. C. and Mentch, Frank D. and Langenberg, Claudia and Scott, Robert A. and Zhao, Jing Hua and Hemani, Gibran and Ring, Susan M. and Bennett, Amanda J. and Gaulton, Kyle J. and Fernandez-Tajes, Juan and van Zuydam, Natalie R. and Medina-Gomez, Carolina and de Haan, Hugoline G. and Rosendaal, Frits R. and Kutalik, Zolt{\´a}n and Marques-Vidal, Pedro and Das, Shikta and Willemsen, Gonneke and Mbarek, Hamdi and M{\"u}ller-Nurasyid, Martina and Standl, Marie and Appel, Emil V. R. and Fonvig, Cilius Esmann and Trier, Caecilie and van Beijsterveldt, Catharina E. M. and Murcia, Mario and Bustamante, Mariona and Bon{\`a}s-Guarch, S{\´i}lvia and Hougaard, David M. and Mercader, Josep M. and Linneberg, Allan and Schraut, Katharina E. and Lind, Penelope A. and Medland, Sarah Elizabeth and Shields, Beverley M. and Knight, Bridget A. and Chai, Jin-Fang and Panoutsopoulou, Kalliope and Bartels, Meike and S{\´a}nchez, Friman and Stokholm, Jakob and Torrents, David and Vinding, Rebecca K. and Willems, Sara M. and Atalay, Mustafa and Chawes, Bo L. and Kovacs, Peter and Prokopenko, Inga and Tuke, Marcus A. and Yaghootkar, Hanieh and Ruth, Katherine S. and Jones, Samuel E. and Loh, Po-Ru and Murray, Anna and Weedon, Michael N. and T{\"o}njes, Anke and Stumvoll, Michael and Michaelsen, Kim Fleischer and Eloranta, Aino-Maija and Lakka, Timo A. and van Duijn, Cornelia M. and Kiess, Wieland and Koerner, Antje and Niinikoski, Harri and Pahkala, Katja and Raitakari, Olli T. and Jacobsson, Bo and Zeggini, Eleftheria and Dedoussis, George V. and Teo, Yik-Ying and Saw, Seang-Mei and Montgomery, Grant W. and Campbell, Harry and Wilson, James F. and Vrijkotte, Tanja G. M. and Vrijheid, Martine and de Geus, Eco J. C. N. and Hayes, M. Geoffrey and Kadarmideen, Haja N. and Holm, Jens-Christian and Beilin, Lawrence J. and Pennell, Craig E. and Heinrich, Joachim and Adair, Linda S. and Borja, Judith B. and Mohlke, Karen L. and Eriksson, Johan G. and Widen, Elisabeth E. and Hattersley, Andrew T. and Spector, Tim D. and Kaehoenen, Mika and Viikari, Jorma S. and Lehtimaeki, Terho and Boomsma, Dorret I. and Sebert, Sylvain and Vollenweider, Peter and Sorensen, Thorkild I. A. and Bisgaard, Hans and Bonnelykke, Klaus and Murray, Jeffrey C. and Melbye, Mads and Nohr, Ellen A. and Mook-Kanamori, Dennis O. and Rivadeneira, Fernando and Hofman, Albert and Felix, Janine F. and Jaddoe, Vincent W. V. and Hansen, Torben and Pisinger, Charlotta and Vaag, Allan A. and Pedersen, Oluf and Uitterlinden, Andre G. and Jarvelin, Marjo-Riitta and Power, Christine and Hypponen, Elina and Scholtens, Denise M. and Lowe, William L. and Smith, George Davey and Timpson, Nicholas J. and Morris, Andrew P. and Wareham, Nicholas J. and Hakonarson, Hakon and Grant, Struan F. A. and Frayling, Timothy M. and Lawlor, Debbie A. and Njolstad, Pal R. and Johansson, Stefan and Ong, Ken K. and McCarthy, Mark I. and Perry, John R. B. and Evans, David M. and Freathy, Rachel M.},
  title     = {Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors},
  series = {Nature genetics},
  volume    = {51},
  journal   = {Nature genetics},
  number    = {5},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {EGG Consortium},
  issn      = {1061-4036},
  pages     = {804 -- +},
  year      = {2019},
  abstract  = {Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.},
  language  = {en}
}
@article{MiddeldorpMahajanHorikoshietal.2019,
  author    = {Middeldorp, Christel M. and Mahajan, Anubha and Horikoshi, Momoko and Robertson, Neil R. and Beaumont, Robin N. and Bradfield, Jonathan P. and Bustamante, Mariona and Cousminer, Diana L. and Day, Felix R. and De Silva, N. Maneka and Guxens, Monica and Mook-Kanamori, Dennis O. and St Pourcain, Beate and Warrington, Nicole M. and Adair, Linda S. and Ahlqvist, Emma and Ahluwalia, Tarunveer Singh and Almgren, Peter and Ang, Wei and Atalay, Mustafa and Auvinen, Juha and Bartels, Meike and Beckmann, Jacques S. and Bilbao, Jose Ramon and Bond, Tom and Borja, Judith B. and Cavadino, Alana and Charoen, Pimphen and Chen, Zhanghua and Coin, Lachlan and Cooper, Cyrus and Curtin, John A. and Custovic, Adnan and Das, Shikta and Davies, Gareth E. and Dedoussis, George V. and Duijts, Liesbeth and Eastwood, Peter R. and Eliasen, Anders U. and Elliott, Paul and Eriksson, Johan G. and Estivill, Xavier and Fadista, Joao and Fedko, Iryna O. and Frayling, Timothy M. and Gaillard, Romy and Gauderman, W. James and Geller, Frank and Gilliland, Frank and Gilsanz, Vincente and Granell, Raquel and Grarup, Niels and Groop, Leif and Hadley, Dexter and Hakonarson, Hakon and Hansen, Torben and Hartman, Catharina A. and Hattersley, Andrew T. and Hayes, M. Geoffrey and Hebebrand, Johannes and Heinrich, Joachim and Helgeland, Oyvind and Henders, Anjali K. and Henderson, John and Henriksen, Tine B. and Hirschhorn, Joel N. and Hivert, Marie-France and Hocher, Berthold and Holloway, John W. and Holt, Patrick and Hottenga, Jouke-Jan and Hypponen, Elina and Iniguez, Carmen and Johansson, Stefan and Jugessur, Astanand and Kahonen, Mika and Kalkwarf, Heidi J. and Kaprio, Jaakko and Karhunen, Ville and Kemp, John P. and Kerkhof, Marjan and Koppelman, Gerard H. and Korner, Antje and Kotecha, Sailesh and Kreiner-Moller, Eskil and Kulohoma, Benard and Kumar, Ashish and Kutalik, Zoltan and Lahti, Jari and Lappe, Joan M. and Larsson, Henrik and Lehtimaki, Terho and Lewin, Alexandra M. and Li, Jin and Lichtenstein, Paul and Lindgren, Cecilia M. and Lindi, Virpi and Linneberg, Allan and Liu, Xueping and Liu, Jun and Lowe, William L. and Lundstrom, Sebastian and Lyytikainen, Leo-Pekka and Ma, Ronald C. W. and Mace, Aurelien and Magi, Reedik and Magnus, Per and Mamun, Abdullah A. and Mannikko, Minna and Martin, Nicholas G. and Mbarek, Hamdi and McCarthy, Nina S. and Medland, Sarah E. and Melbye, Mads and Melen, Erik and Mohlke, Karen L. and Monnereau, Claire and Morgen, Camilla S. and Morris, Andrew P. and Murray, Jeffrey C. and Myhre, Ronny and Najman, Jackob M. and Nivard, Michel G. and Nohr, Ellen A. and Nolte, Ilja M. and Ntalla, Ioanna and Oberfield, Sharon E. and Oken, Emily and Oldehinkel, Albertine J. and Pahkala, Katja and Palviainen, Teemu and Panoutsopoulou, Kalliope and Pedersen, Oluf and Pennell, Craig E. and Pershagen, Goran and Pitkanen, Niina and Plomin, Robert and Power, Christine and Prasad, Rashmi B. and Prokopenko, Inga and Pulkkinen, Lea and Raikkonen, Katri and Raitakari, Olli T. and Reynolds, Rebecca M. and Richmond, Rebecca C. and Rivadeneira, Fernando and Rodriguez, Alina and Rose, Richard J. and Salem, Rany and Santa-Marina, Loreto and Saw, Seang-Mei and Schnurr, Theresia M. and Scott, James G. and Selzam, Saskia and Shepherd, John A. and Simpson, Angela and Skotte, Line and Sleiman, Patrick M. A. and Snieder, Harold and Sorensen, Thorkild I. A. and Standl, Marie and Steegers, Eric A. P. and Strachan, David P. and Straker, Leon and Strandberg, Timo and Taylor, Michelle and Teo, Yik-Ying and Thiering, Elisabeth and Torrent, Maties and Tyrrell, Jessica and Uitterlinden, Andre G. and van Beijsterveldt, Toos and van der Most, Peter J. and van Duijn, Cornelia M. and Viikari, Jorma and Vilor-Tejedor, Natalia and Vogelezang, Suzanne and Vonk, Judith M. and Vrijkotte, Tanja G. M. and Vuoksimaa, Eero and Wang, Carol A. and Watkins, William J. and Wichmann, H-Erich and Willemsen, Gonneke and Williams, Gail M. and Wilson, James F. and Wray, Naomi R. and Xu, Shujing and Xu, Cheng-Jian and Yaghootkar, Hanieh and Yi, Lu and Zafarmand, Mohammad Hadi and Zeggini, Eleftheria and Zemel, Babette S. and Hinney, Anke and Lakka, Timo A. and Whitehouse, Andrew J. O. and Sunyer, Jordi and Widen, Elisabeth E. and Feenstra, Bjarke and Sebert, Sylvain and Jacobsson, Bo and Njolstad, Pal R. and Stoltenberg, Camilla and Smith, George Davey and Lawlor, Debbie A. and Paternoster, Lavinia and Timpson, Nicholas J. and Ong, Ken K. and Bisgaard, Hans and Bonnelykke, Klaus and Jaddoe, Vincent W. V. and Tiemeier, Henning and Jarvelin, Marjo-Riitta and Evans, David M. and Perry, John R. B. and Grant, Struan F. A. and Boomsma, Dorret I. and Freathy, Rachel M. and McCarthy, Mark I. and Felix, Janine F.},
  title     = {The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia},
  series = {European journal of epidemiology},
  volume    = {34},
  journal   = {European journal of epidemiology},
  number    = {3},
  publisher = {Springer},
  address   = {Dordrecht},
  organization    = {EArly Genetics Lifecourse EGG Consortium EGG Membership EAGLE Membership},
  issn      = {0393-2990},
  doi       = {10.1007/s10654-019-00502-9},
  pages     = {279 -- 300},
  year      = {2019},
  abstract  = {The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.},
  language  = {en}
}
@article{NitschkeWangSchmiederetal.2013,
  author    = {Nitschke, Felix and Wang, Peixiang and Schmieder, Peter and Girard, Jean-Marie and Awrey, Donald E. and Wang, Tony and Israelian, Johan and Zhao, XiaoChu and Turnbull, Julie and Heydenreich, Matthias and Kleinpeter, Erich and Steup, Martin and Minassian, Berge A.},
  title     = {Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy lafora disease},
  series = {Cell metabolism},
  volume    = {17},
  journal   = {Cell metabolism},
  number    = {5},
  publisher = {Cell Press},
  address   = {Cambridge},
  issn      = {1550-4131},
  doi       = {10.1016/j.cmet.2013.04.006},
  pages     = {756 -- 767},
  year      = {2013},
  abstract  = {Laforin or malin deficiency causes Lafora disease, characterized by altered glycogen metabolism and teenage-onset neurodegeneration with intractable and invariably fatal epilepsy. Plant starches possess small amounts of metabolically essential monophosphate esters. Glycogen contains similar phosphate amounts, which are thought to originate from a glycogen synthase error side reaction and therefore lack any specific function. Glycogen is also believed to lack monophosphates at glucosyl carbon C6, an essential phosphorylation site in plant starch metabolism. We now show that glycogen phosphorylation is not due to a glycogen synthase side reaction, that C6 is a major glycogen phosphorylation site, and that C6 monophosphates predominate near centers of glycogen molecules and positively correlate with glycogen chain lengths. Laforin or malin deficiency causes C6 hyperphosphorylation, which results in malformed long-chained glycogen that accumulates in many tissues, causing neurodegeneration in brain. Our work advances the understanding of Lafora disease pathogenesis and suggests that glycogen phosphorylation has important metabolic function.},
  language  = {en}
}
@article{WangKirbyFurlongetal.2012,
  author    = {Wang, E. and Kirby, E. and Furlong, K. P. and van Soest, M. and Xu, G. and Shi, X. and Kamp, P. J. J. and Hodges, K. V.},
  title     = {Two-phase growth of high topography in eastern Tibet during the Cenozoic},
  series = {NATURE GEOSCIENCE},
  volume    = {5},
  journal   = {NATURE GEOSCIENCE},
  number    = {9},
  publisher = {NATURE PUBLISHING GROUP},
  address   = {NEW YORK},
  issn      = {1752-0894},
  doi       = {10.1038/NGEO1538},
  pages     = {640 -- 645},
  year      = {2012},
  abstract  = {High topography in eastern Tibet is thought to have formed when deep crust beneath the central Tibetan Plateau flowed towards the plateau margin, causing crustal thickening and surface uplift(1,2). Rapid exhumation starting about 10-15 million years ago is inferred to mark the onset of surface uplift and fluvial incision(3-6). Although geophysical data are consistent with weak crust capable of flow(7,8), it is unclear how the timing(9) and amount of deformation adjacent to the Sichuan Basin during the Cenozoic era can be explained in this way(10,11). Here we use thermochronology to measure the cooling histories of rocks exposed in a section that stretches vertically over 3 km adjacent to the Sichuan Basin. Our thermal models of exhumation-driven cooling show that these rocks, and hence the plateau margin, were subject to slow, steady exhumation during early Cenozoic time, followed by two pulses of rapid exhumation, one beginning 30-25 million years ago and a second 10-15 million years ago that continues to present. Our findings imply that significant topographic relief existed adjacent to the Sichuan Basin before the Indo-Asian collision. Furthermore, the onset of Cenozoic mountain building probably pre-dated development of the weak lower crust, implying that early topography was instead formed during thickening of the upper crust along faults. We suggest that episodes of mountain building may reflect distinct geodynamic mechanisms of crustal thickening.},
  language  = {en}
}
@article{TiegsCostelloIskenetal.2019,
  author    = {Tiegs, Scott D. and Costello, David M. and Isken, Mark W. and Woodward, Guy and McIntyre, Peter B. and Gessner, Mark O. and Chauvet, Eric and Griffiths, Natalie A. and Flecker, Alex S. and Acuna, Vicenc and Albarino, Ricardo and Allen, Daniel C. and Alonso, Cecilia and Andino, Patricio and Arango, Clay and Aroviita, Jukka and Barbosa, Marcus V. M. and Barmuta, Leon A. and Baxter, Colden V. and Bell, Thomas D. C. and Bellinger, Brent and Boyero, Luz and Brown, Lee E. and Bruder, Andreas and Bruesewitz, Denise A. and Burdon, Francis J. and Callisto, Marcos and Canhoto, Cristina and Capps, Krista A. and Castillo, Maria M. and Clapcott, Joanne and Colas, Fanny and Colon-Gaud, Checo and Cornut, Julien and Crespo-Perez, Veronica and Cross, Wyatt F. and Culp, Joseph M. and Danger, Michael and Dangles, Olivier and de Eyto, Elvira and Derry, Alison M. and Diaz Villanueva, Veronica and Douglas, Michael M. and Elosegi, Arturo and Encalada, Andrea C. and Entrekin, Sally and Espinosa, Rodrigo and Ethaiya, Diana and Ferreira, Veronica and Ferriol, Carmen and Flanagan, Kyla M. and Fleituch, Tadeusz and Shah, Jennifer J. Follstad and Frainer, Andre and Friberg, Nikolai and Frost, Paul C. and Garcia, Erica A. and Lago, Liliana Garcia and Garcia Soto, Pavel Ernesto and Ghate, Sudeep and Giling, Darren P. and Gilmer, Alan and Goncalves, Jose Francisco and Gonzales, Rosario Karina and Graca, Manuel A. S. and Grace, Mike and Grossart, Hans-Peter and Guerold, Francois and Gulis, Vlad and Hepp, Luiz U. and Higgins, Scott and Hishi, Takuo and Huddart, Joseph and Hudson, John and Imberger, Samantha and Iniguez-Armijos, Carlos and Iwata, Tomoya and Janetski, David J. and Jennings, Eleanor and Kirkwood, Andrea E. and Koning, Aaron A. and Kosten, Sarian and Kuehn, Kevin A. and Laudon, Hjalmar and Leavitt, Peter R. and Lemes da Silva, Aurea L. and Leroux, Shawn J. and Leroy, Carri J. and Lisi, Peter J. and MacKenzie, Richard and Marcarelli, Amy M. and Masese, Frank O. and Mckie, Brendan G. and Oliveira Medeiros, Adriana and Meissner, Kristian and Milisa, Marko and Mishra, Shailendra and Miyake, Yo and Moerke, Ashley and Mombrikotb, Shorok and Mooney, Rob and Moulton, Tim and Muotka, Timo and Negishi, Junjiro N. and Neres-Lima, Vinicius and Nieminen, Mika L. and Nimptsch, Jorge and Ondruch, Jakub and Paavola, Riku and Pardo, Isabel and Patrick, Christopher J. and Peeters, Edwin T. H. M. and Pozo, Jesus and Pringle, Catherine and Prussian, Aaron and Quenta, Estefania and Quesada, Antonio and Reid, Brian and Richardson, John S. and Rigosi, Anna and Rincon, Jose and Risnoveanu, Geta and Robinson, Christopher T. and Rodriguez-Gallego, Lorena and Royer, Todd V. and Rusak, James A. and Santamans, Anna C. and Selmeczy, Geza B. and Simiyu, Gelas and Skuja, Agnija and Smykla, Jerzy and Sridhar, Kandikere R. and Sponseller, Ryan and Stoler, Aaron and Swan, Christopher M. and Szlag, David and Teixeira-de Mello, Franco and Tonkin, Jonathan D. and Uusheimo, Sari and Veach, Allison M. and Vilbaste, Sirje and Vought, Lena B. M. and Wang, Chiao-Ping and Webster, Jackson R. and Wilson, Paul B. and Woelfl, Stefan and Xenopoulos, Marguerite A. and Yates, Adam G. and Yoshimura, Chihiro and Yule, Catherine M. and Zhang, Yixin X. and Zwart, Jacob A.},
  title     = {Global patterns and drivers of ecosystem functioning in rivers and riparian zones},
  series = {Science Advances},
  volume    = {5},
  journal   = {Science Advances},
  number    = {1},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {2375-2548},
  doi       = {10.1126/sciadv.aav0486},
  pages     = {8},
  year      = {2019},
  abstract  = {River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth's biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented "next-generation biomonitoring" by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.},
  language  = {en}
}
@article{DenglerWagnerDembiczetal.2018,
  author    = {Dengler, J{\"u}rgen and Wagner, Viktoria and Dembicz, Iwona and Garcia-Mijangos, Itziar and Naqinezhad, Alireza and Boch, Steffen and Chiarucci, Alessandro and Conradi, Timo and Filibeck, Goffredo and Guarino, Riccardo and Janisova, Monika and Steinbauer, Manuel J. and Acic, Svetlana and Acosta, Alicia T. R. and Akasaka, Munemitsu and Allers, Marc-Andre and Apostolova, Iva and Axmanova, Irena and Bakan, Branko and Baranova, Alina and Bardy-Durchhalter, Manfred and Bartha, Sandor and Baumann, Esther and Becker, Thomas and Becker, Ute and Belonovskaya, Elena and Bengtsson, Karin and Benito Alonso, Jose Luis and Berastegi, Asun and Bergamini, Ariel and Bonini, Ilaria and Bruun, Hans Henrik and Budzhak, Vasyl and Bueno, Alvaro and Antonio Campos, Juan and Cancellieri, Laura and Carboni, Marta and Chocarro, Cristina and Conti, Luisa and Czarniecka-Wiera, Marta and De Frenne, Pieter and Deak, Balazs and Didukh, Yakiv P. and Diekmann, Martin and Dolnik, Christian and Dupre, Cecilia and Ecker, Klaus and Ermakov, Nikolai and Erschbamer, Brigitta and Escudero, Adrian and Etayo, Javier and Fajmonova, Zuzana and Felde, Vivian A. and Fernandez Calzado, Maria Rosa and Finckh, Manfred and Fotiadis, Georgios and Fracchiolla, Mariano and Ganeva, Anna and Garcia-Magro, Daniel and Gavilan, Rosario G. and Germany, Markus and Giladi, Itamar and Gillet, Francois and Giusso del Galdo, Gian Pietro and Gonzalez, Jose M. and Grytnes, John-Arvid and Hajek, Michal and Hajkova, Petra and Helm, Aveliina and Herrera, Mercedes and Hettenbergerova, Eva and Hobohm, Carsten and Huellbusch, Elisabeth M. and Ingerpuu, Nele and Jandt, Ute and Jeltsch, Florian and Jensen, Kai and Jentsch, Anke and Jeschke, Michael and Jimenez-Alfaro, Borja and Kacki, Zygmunt and Kakinuma, Kaoru and Kapfer, Jutta and Kavgaci, Ali and Kelemen, Andras and Kiehl, Kathrin and Koyama, Asuka and Koyanagi, Tomoyo F. and Kozub, Lukasz and Kuzemko, Anna and Kyrkjeeide, Magni Olsen and Landi, Sara and Langer, Nancy and Lastrucci, Lorenzo and Lazzaro, Lorenzo and Lelli, Chiara and Leps, Jan and Loebel, Swantje and Luzuriaga, Arantzazu L. and Maccherini, Simona and Magnes, Martin and Malicki, Marek and Marceno, Corrado and Mardari, Constantin and Mauchamp, Leslie and May, Felix and Michelsen, Ottar and Mesa, Joaquin Molero and Molnar, Zsolt and Moysiyenko, Ivan Y. and Nakaga, Yuko K. and Natcheva, Rayna and Noroozi, Jalil and Pakeman, Robin J. and Palpurina, Salza and Partel, Meelis and Paetsch, Ricarda and Pauli, Harald and Pedashenko, Hristo and Peet, Robert K. and Pielech, Remigiusz and Pipenbaher, Natasa and Pirini, Chrisoula and Pleskova, Zuzana and Polyakova, Mariya A. and Prentice, Honor C. and Reinecke, Jennifer and Reitalu, Triin and Pilar Rodriguez-Rojo, Maria and Rolecek, Jan and Ronkin, Vladimir and Rosati, Leonardo and Rosen, Ejvind and Ruprecht, Eszter and Rusina, Solvita and Sabovljevic, Marko and Maria Sanchez, Ana and Savchenko, Galina and Schuhmacher, Oliver and Skornik, Sonja and Sperandii, Marta Gaia and Staniaszek-Kik, Monika and Stevanovic-Dajic, Zora and Stock, Marin and Suchrow, Sigrid and Sutcliffe, Laura M. E. and Swacha, Grzegorz and Sykes, Martin and Szabo, Anna and Talebi, Amir and Tanase, Catalin and Terzi, Massimo and Tolgyesi, Csaba and Torca, Marta and Torok, Peter and Tothmeresz, Bela and Tsarevskaya, Nadezda and Tsiripidis, Ioannis and Tzonev, Rossen and Ushimaru, Atushi and Valko, Orsolya and van der Maarel, Eddy and Vanneste, Thomas and Vashenyak, Iuliia and Vassilev, Kiril and Viciani, Daniele and Villar, Luis and Virtanen, Risto and Kosic, Ivana Vitasovic and Wang, Yun and Weiser, Frank and Went, Julia and Wesche, Karsten and White, Hannah and Winkler, Manuela and Zaniewski, Piotr T. and Zhang, Hui and Ziv, Yaron and Znamenskiy, Sergey and Biurrun, Idoia},
  title     = {GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands},
  series = {Phytocoenologia},
  volume    = {48},
  journal   = {Phytocoenologia},
  number    = {3},
  publisher = {Cramer},
  address   = {Stuttgart},
  issn      = {0340-269X},
  doi       = {10.1127/phyto/2018/0267},
  pages     = {331 -- 347},
  year      = {2018},
  abstract  = {GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.},
  language  = {en}
}
@article{MuellerFoerstendorfSteudtneretal.2019,
  author    = {M{\"u}ller, Katharina and Foerstendorf, Harald and Steudtner, Robin and Tsushima, Satoru and Kumke, Michael Uwe and Lef{\`e}vre, Gr{\´e}gory and Rothe, J{\"o}rg and Mason, Harris and Szab{\´o}, Zolt{\´a}n and Yang, Ping and Adam, Christian K. R. and Andr{\´e}, R{\´e}mi and Brennenstuhl, Katlen and Chiorescu, Ion and Cho, Herman M. and Creff, Ga{\"e}lle and Coppin, Fr{\´e}d{\´e}ric and Dardenne, Kathy and Den Auwer, Christophe and Drobot, Bj{\"o}rn and Eidner, Sascha and Hess, Nancy J. and Kaden, Peter and Kremleva, Alena and Kretzschmar, Jerome and Kr{\"u}ger, Sven and Platts, James A. and Panak, Petra and Polly, Robert and Powell, Brian A. and Rabung, Thomas and Redon, Roland and Reiller, Pascal E. and R{\"o}sch, Notker and Rossberg, Andr{\´e} and Scheinost, Andreas C. and Schimmelpfennig, Bernd and Schreckenbach, Georg and Skerencak-Frech, Andrej and Sladkov, Vladimir and Solari, Pier Lorenzo and Wang, Zheming and Washton, Nancy M. and Zhang, Xiaobin},
  title     = {Interdisciplinary Round-Robin Test on molecular spectroscopy of the U(VI) Acetate System},
  series = {ACS omega / American Chemical Society},
  volume    = {4},
  journal   = {ACS omega / American Chemical Society},
  number    = {5},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {2470-1343},
  doi       = {10.1021/acsomega.9b00164},
  pages     = {8167 -- 8177},
  year      = {2019},
  abstract  = {A comprehensive molecular analysis of a simple aqueous complexing system. U(VI) acetate. selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). Twenty laboratories from six different countries with a focus on actinide or geochemical research participated and contributed to this scientific endeavor. The outcomes of this RRT were considered on two levels of complexity: first, within each technical discipline, conformities as well as discrepancies of the results and their sources were evaluated. The raw data from the different experimental approaches were found to be generally consistent. In particular, for complex setups such as accelerator-based X-ray absorption spectroscopy, the agreement between the raw data was high. By contrast, luminescence spectroscopic data turned out to be strongly related to the chosen acquisition parameters. Second, the potentials and limitations of coupling various spectroscopic and theoretical approaches for the comprehensive study of actinide molecular complexes were assessed. Previous spectroscopic data from the literature were revised and the benchmark data on the U(VI) acetate system provided an unambiguous molecular interpretation based on the correlation of spectroscopic and theoretical results. The multimethodologic approach and the conclusions drawn address not only important aspects of actinide spectroscopy but particularly general aspects of modern molecular analytical chemistry.},
  language  = {en}
}
@article{WangRazzaqRudolphetal.2018,
  author    = {Wang, Li and Razzaq, Muhammad Yasar and Rudolph, Tobias and Heuchel, Matthias and N{\"o}chel, Ulrich and Mansfeld, Ulrich and Jiang, Yi and Gould, Oliver E. C. and Behl, Marc and Kratz, Karl and Lendlein, Andreas},
  title     = {Reprogrammable, magnetically controlled polymeric nanocomposite actuators},
  series = {Material horizons},
  volume    = {5},
  journal   = {Material horizons},
  number    = {5},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2051-6347},
  doi       = {10.1039/c8mh00266e},
  pages     = {861 -- 867},
  year      = {2018},
  abstract  = {Soft robots and devices with the advanced capability to perform adaptive motions similar to that of human beings often have stimuli-sensitive polymeric materials as the key actuating component. The external signals triggering the smart polymers' actuations can be transmitted either via a direct physical connection between actuator and controlling unit (tethered) or remotely without a connecting wire. However, the vast majority of such polymeric actuator materials are limited to one specific type of motion as their geometrical information is chemically fixed. Here, we present magnetically driven nanocomposite actuators, which can be reversibly reprogrammed to different actuation geometries by a solely physical procedure. Our approach is based on nanocomposite materials comprising spatially segregated crystallizable actuation and geometry determining units. Upon exposure to a specific magnetic field strength the actuators' geometric memory is erased by the melting of the geometry determining units allowing the implementation of a new actuator shape. The actuation performance of the nanocomposites can be tuned and the technical significance was demonstrated in a multi-cyclic experiment with several hundreds of repetitive free-standing shape shifts without losing performance.},
  language  = {en}
}
@article{LeFriantIshizukaBoudonetal.2015,
  author    = {Le Friant, A. and Ishizuka, O. and Boudon, G. and Palmer, M. R. and Talling, P. J. and Villemant, B. and Adachi, T. and Aljahdali, M. and Breitkreuz, C. and Brunet, M. and Caron, B. and Coussens, M. and Deplus, C. and Endo, D. and Feuillet, N. and Fraas, A. J. and Fujinawa, A. and Hart, M. B. and Hatfield, R. G. and Hornbach, M. and Jutzeler, M. and Kataoka, K. S. and Komorowski, J. -C. and Lebas, E. and Lafuerza, S. and Maeno, F. and Manga, M. and Martinez-Colon, M. and McCanta, M. and Morgan, S. and Saito, T. and Slagle, A. and Sparks, S. and Stinton, A. and Stroncik, Nicole and Subramanyam, K. S. V. and Tamura, Yui and Trofimovs, J. and Voight, B. and Wall-Palmer, D. and Wang, F. and Watt, S. F. L.},
  title     = {Submarine record of volcanic island construction and collapse in the Lesser Antilles arc: First scientific drilling of submarine volcanic island landslides by IODP Expedition 340},
  series = {Geochemistry, geophysics, geosystems},
  volume    = {16},
  journal   = {Geochemistry, geophysics, geosystems},
  number    = {2},
  publisher = {American Geophysical Union},
  address   = {Washington},
  issn      = {1525-2027},
  doi       = {10.1002/2014GC005652},
  pages     = {420 -- 442},
  year      = {2015},
  abstract  = {IODP Expedition 340 successfully drilled a series of sites offshore Montserrat, Martinique and Dominica in the Lesser Antilles from March to April 2012. These are among the few drill sites gathered around volcanic islands, and the first scientific drilling of large and likely tsunamigenic volcanic island-arc landslide deposits. These cores provide evidence and tests of previous hypotheses for the composition and origin of those deposits. Sites U1394, U1399, and U1400 that penetrated landslide deposits recovered exclusively seafloor sediment, comprising mainly turbidites and hemipelagic deposits, and lacked debris avalanche deposits. This supports the concepts that i/ volcanic debris avalanches tend to stop at the slope break, and ii/ widespread and voluminous failures of preexisting low-gradient seafloor sediment can be triggered by initial emplacement of material from the volcano. Offshore Martinique (U1399 and 1400), the landslide deposits comprised blocks of parallel strata that were tilted or microfaulted, sometimes separated by intervals of homogenized sediment (intense shearing), while Site U1394 offshore Montserrat penetrated a flat-lying block of intact strata. The most likely mechanism for generating these large-scale seafloor sediment failures appears to be propagation of a decollement from proximal areas loaded and incised by a volcanic debris avalanche. These results have implications for the magnitude of tsunami generation. Under some conditions, volcanic island landslide deposits composed of mainly seafloor sediment will tend to form smaller magnitude tsunamis than equivalent volumes of subaerial block-rich mass flows rapidly entering water. Expedition 340 also successfully drilled sites to access the undisturbed record of eruption fallout layers intercalated with marine sediment which provide an outstanding high-resolution data set to analyze eruption and landslides cycles, improve understanding of magmatic evolution as well as offshore sedimentation processes.},
  language  = {en}
}
@article{TownsleyBroosCorcoranetal.2011,
  author    = {Townsley, Leisa K. and Broos, Patrick S. and Corcoran, Michael F. and Feigelson, Eric D. and Gagne, Marc and Montmerle, Thierry and Oey, M. S. and Smith, Nathan and Garmire, Gordon P. and Getman, Konstantin V. and Povich, Matthew S. and Evans, Nancy Remage and Naze, Yael and Parkin, E. R. and Preibisch, Thomas and Wang, Junfeng and Wou, Scott J. and Chu, You-Hua and Cohen, David H. and Gruendl, Robert A. and Hamaguchi, Kenji and King, Robert R. and Mac Low, Mordecai-Mark and McCaughrean, Mark J. and Moffat, Anthony F. J. and Oskinova, Lida and Pittard, Julian M. and Stassun, Keivan G. and Ud-Doula, Asif and Walborn, Nolan R. and Waldron, Wayne L. and Churchwell, Ed and Nictiols, J. S. and Owocki, Stanley P. and Schulz, Norbert S.},
  title     = {An introduction to the chandra carina complex project},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series},
  volume    = {194},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series},
  number    = {1},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {0067-0049},
  doi       = {10.1088/0067-0049/194/1/1},
  pages     = {28},
  year      = {2011},
  abstract  = {The Great Nebula in Carina provides an exceptional view into the violent massive star formation and feedback that typifies giant H II regions and starburst galaxies. We have mapped the Carina star-forming complex in X-rays, using archival Chandra data and a mosaic of 20 new 60 ks pointings using the Chandra X-ray Observatory's Advanced CCD Imaging Spectrometer, as a testbed for understanding recent and ongoing star formation and to probe Carina's regions of bright diffuse X-ray emission. This study has yielded a catalog of properties of > 14,000 X-ray point sources;> 9800 of them have multiwavelength counterparts. Using Chandra's unsurpassed X-ray spatial resolution, we have separated these point sources from the extensive, spatially-complex diffuse emission that pervades the region; X-ray properties of this diffuse emission suggest that it traces feedback from Carina's massive stars. In this introductory paper, we motivate the survey design, describe the Chandra observations, and present some simple results, providing a foundation for the 15 papers that follow in this special issue and that present detailed catalogs, methods, and science results.},
  language  = {en}
}
@misc{DengWangXuaetal.2020,
  author    = {Deng, Zijun and Wang, Weiwei and Xua, Xun and Gould, Oliver E. C. and Kratz, Karl and Ma, Nan and Lendlein, Andreas},
  title     = {Polymeric sheet actuators with programmable bioinstructivity},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {4},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-51549},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-515490},
  pages     = {9},
  year      = {2020},
  abstract  = {Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.},
  language  = {en}
}
@article{YanXueJiangetal.2022,
  author    = {Yan, Xiaoli and Xue, Zhike and Jiang, Chaowei and Priest, E. R. and Kliem, Bernhard and Yang, Liheng and Wang, Jincheng and Kong, Defang and Song, Yongliang and Feng, Xueshang and Liu, Zhong},
  title     = {Fast plasmoid-mediated reconnection in a solar flare},
  series = {Nature Communications},
  volume    = {13},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Nature Publishing Group UK},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-022-28269-w},
  pages     = {14},
  year      = {2022},
  abstract  = {Magnetic reconnection is a multi-faceted process of energy conversion in astrophysical, space and laboratory plasmas that operates at microscopic scales but has macroscopic drivers and consequences. Solar flares present a key laboratory for its study, leaving imprints of the microscopic physics in radiation spectra and allowing the macroscopic evolution to be imaged, yet a full observational characterization remains elusive. Here we combine high resolution imaging and spectral observations of a confined solar flare at multiple wavelengths with data-constrained magnetohydrodynamic modeling to study the dynamics of the flare plasma from the current sheet to the plasmoid scale. The analysis suggests that the flare resulted from the interaction of a twisted magnetic flux rope surrounding a filament with nearby magnetic loops whose feet are anchored in chromospheric fibrils. Bright cusp-shaped structures represent the region around a reconnecting separator or quasi-separator (hyperbolic flux tube). The fast reconnection, which is relevant for other astrophysical environments, revealed plasmoids in the current sheet and separatrices and associated unresolved turbulent motions. Solar flares provide wide range of observational details about fundamental processes involved. Here, the authors show evidence for magnetic reconnection in a strong confined solar flare displaying all four reconnection flows with plasmoids in the current sheet and the separatrices.},
  language  = {en}
}
@article{DrozdovAllisonShpritsetal.2022,
  author    = {Drozdov, Alexander and Allison, Hayley J. and Shprits, Yuri Y. and Usanova, Maria E. and Saikin, Anthony and Wang, Dedong},
  title     = {Depletions of Multi-MeV Electrons and their association to Minima in Phase Space Density},
  series = {Geophysical research letters},
  volume    = {49},
  journal   = {Geophysical research letters},
  number    = {8},
  publisher = {American Geophysical Union},
  address   = {Washington},
  issn      = {0094-8276},
  doi       = {10.1029/2021GL097620},
  pages     = {11},
  year      = {2022},
  abstract  = {Fast-localized electron loss, resulting from interactions with electromagnetic ion cyclotron (EMIC) waves, can produce deepening minima in phase space density (PSD) radial profiles. Here, we perform a statistical analysis of local PSD minima to quantify how readily these are associated with radiation belt depletions. The statistics of PSD minima observed over a year are compared to the Versatile Electron Radiation Belts (VERB) simulations, both including and excluding EMIC waves. The observed minima distribution can only be achieved in the simulation including EMIC waves, indicating their importance in the dynamics of the radiation belts. By analyzing electron flux depletions in conjunction with the observed PSD minima, we show that, in the heart of the outer radiation belt (L* < 5), on average, 53\% of multi-MeV electron depletions are associated with PSD minima, demonstrating that fast localized loss by interactions with EMIC waves are a common and crucial process for ultra-relativistic electron populations.},
  language  = {en}
}
@article{AseevShpritsDrozdovetal.2017,
  author    = {Aseev, Nikita and Shprits, Yuri Y. and Drozdov, Alexander and Kellerman, Adam C. and Usanova, Maria E. and Wang, D. and Zhelavskaya, Irina},
  title     = {Signatures of Ultrarelativistic Electron Loss in the Heart of the Outer Radiation Belt Measured by Van Allen Probes},
  series = {Journal of geophysical research : Space physics},
  volume    = {122},
  journal   = {Journal of geophysical research : Space physics},
  publisher = {American Geophysical Union},
  address   = {Washington},
  issn      = {2169-9380},
  doi       = {10.1002/2017JA024485},
  pages     = {10102 -- 10111},
  year      = {2017},
  abstract  = {Up until recently, signatures of the ultrarelativistic electron loss driven by electromagnetic ion cyclotron (EMIC) waves in the Earth's outer radiation belt have been limited to direct or indirect measurements of electron precipitation or the narrowing of normalized pitch angle distributions in the heart of the belt. In this study, we demonstrate additional observational evidence of ultrarelativistic electron loss that can be driven by resonant interaction with EMIC waves. We analyzed the profiles derived from Van Allen Probe particle data as a function of time and three adiabatic invariants between 9 October and 29 November 2012. New local minimums in the profiles are accompanied by the narrowing of normalized pitch angle distributions and ground\&\#8208;based detection of EMIC waves. Such a correlation may be indicative of ultrarelativistic electron precipitation into the Earth's atmosphere caused by resonance with EMIC waves.},
  language  = {en}
}
@misc{GorskiJungLietal.2020,
  author    = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.},
  title     = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t},
  number    = {19},
  doi       = {10.25932/publishup-56537},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565379},
  pages     = {14},
  year      = {2020},
  abstract  = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.},
  language  = {en}
}
@article{GorskiJungLietal.2020,
  author    = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.},
  title     = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline},
  series = {Kidney international : official journal of the International Society of Nephrology},
  volume    = {99},
  journal   = {Kidney international : official journal of the International Society of Nephrology},
  number    = {4},
  publisher = {Elsevier},
  address   = {New York},
  organization    = {Lifelines Cohort Study<br /> Regeneron Genetics Ctr},
  issn      = {0085-2538},
  doi       = {10.1016/j.kint.2020.09.030},
  pages     = {926 -- 939},
  year      = {2020},
  abstract  = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.},
  language  = {en}
}
@article{DengWangXuaetal.2020,
  author    = {Deng, Zijun and Wang, Weiwei and Xua, Xun and Gould, Oliver E. C. and Kratz, Karl and Ma, Nan and Lendlein, Andreas},
  title     = {Polymeric sheet actuators with programmable bioinstructivity},
  series = {PNAS},
  volume    = {117},
  journal   = {PNAS},
  number    = {4},
  publisher = {National Academy of Sciences},
  address   = {Washington, DC},
  issn      = {1091-6490},
  doi       = {10.1073/pnas.1910668117},
  pages     = {1895 -- 1901},
  year      = {2020},
  abstract  = {Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.},
  language  = {en}
}