@article{PenningHochmuthKirchner2023, author = {Penning, Isabelle and Hochmuth, J{\"o}rg and Kirchner, Vera}, title = {Virtual Reality}, series = {Handbuch Digitale Instrumente in der {\"O}konomischen Bildung}, journal = {Handbuch Digitale Instrumente in der {\"O}konomischen Bildung}, publisher = {Wochenschau Verlag}, address = {Frankfurt am Main}, isbn = {978-3-7566-1554-4}, pages = {190}, year = {2023}, language = {de} } @article{KirchnerHochmuthPenning2023, author = {Kirchner, Vera and Hochmuth, J{\"o}rg and Penning, Isabelle}, title = {Social Media}, series = {Handbuch digitale Instrumente der {\"O}konomischen Bildung}, journal = {Handbuch digitale Instrumente der {\"O}konomischen Bildung}, publisher = {Wochenschau Verlag}, address = {Frankfurt am Main}, isbn = {978-3-7566-1554-4}, pages = {145 -- 159}, year = {2023}, language = {de} } @article{KirchnerPenning2023, author = {Kirchner, Vera and Penning, Isabelle}, title = {Berufswahl differenzieren(d)}, series = {F{\"o}rdermagazin : Sekundarstufe}, journal = {F{\"o}rdermagazin : Sekundarstufe}, number = {3}, publisher = {Friedrich Verlag}, address = {Hannover}, issn = {2195-7142}, pages = {2 -- 6}, year = {2023}, abstract = {B{\"a}cker:in, Beik{\"o}ch:in oder B{\"u}romanager:in: Welcher berufliche Lebensweg passt zu mir? Gerade f{\"u}r Sch{\"u}ler:innen mit Unterst{\"u}tzungsbedarf kann die Antwort auf diese Frage besonders schwierig sein. Doch Unterricht kann mit vielf{\"a}ltigen Maßnahmen die Berufswahl unterst{\"u}tzen.}, language = {de} } @article{HochmuthKirchner2021, author = {Hochmuth, J{\"o}rg and Kirchner, Vera}, title = {{\"O}konomische Bildung digital}, series = {Unterricht Wirtschaft + Politik}, journal = {Unterricht Wirtschaft + Politik}, number = {1}, publisher = {Friedrich Verlag GmbH}, address = {Hannover}, pages = {48 -- 51}, year = {2021}, language = {de} } @book{KirchnerHinzAlischetal.2022, author = {Kirchner, Vera and Hinz, Carsten and Alisch, Julia and Hammer, Carolin and Klitsch, Constantin and L{\"o}ffler, Robert and Penning, Isabelle and Richter, Christin}, title = {\#WAT 1}, editor = {Kirchner, Vera}, publisher = {Buchner Verlag}, address = {Bamberg}, isbn = {978-3-661-82301-0}, pages = {288}, year = {2022}, language = {de} } @book{KirchnerDeekenHinzetal.2022, author = {Kirchner, Vera and Deeken, Johannes and Hinz, Carsten and Klitsch, Constantin and L{\"o}ffler, Robert and Penning, Isabelle and Richter, Christin and Sch{\"a}fer, David}, title = {Differenzierungsheft}, series = {\#Wirtschaft Band 7/8 - Nordrhein-Westfalen}, journal = {\#Wirtschaft Band 7/8 - Nordrhein-Westfalen}, publisher = {Buchner}, address = {Bamberg}, isbn = {978-3-66182-249-5}, pages = {56}, year = {2022}, language = {de} } @article{NordmeyerKrausZiehmetal.2023, author = {Nordmeyer, Sarah and Kraus, Milena and Ziehm, Matthias and Kirchner, Marieluise and Schafstedde, Marie and Kelm, Marcus and Niquet, Sylvia and Stephen, Mariet Mathew and Baczko, Istvan and Knosalla, Christoph and Schapranow, Matthieu-Patrick and Dittmar, Gunnar and Gotthardt, Michael and Falcke, Martin and Regitz-Zagrosek, Vera and Kuehne, Titus and Mertins, Philipp}, title = {Disease- and sex-specific differences in patients with heart valve disease}, series = {Life Science Alliance}, volume = {6}, journal = {Life Science Alliance}, number = {3}, publisher = {EMBO Press}, address = {Heidelberg}, issn = {2575-1077}, doi = {10.26508/lsa.202201411}, pages = {18}, year = {2023}, abstract = {Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients with aortic stenosis showed more proteins related to fibrosis and less to energy metabolism, whereas female patients showed strong reduction in proteostasis-related proteins. Clinical imaging was in line with proteomic findings, showing elevation of fibrosis in both patient groups and sex differences. Disease-and sex-specific proteomic profiles provide insight into cardiac remodeling in patients with heart valve disease and might help improve the understanding of molecular mechanisms and the development of individualized treatment strategies.}, language = {en} }