@article{BeerenwinkelSingLengaueretal.2005, author = {Beerenwinkel, Niko and Sing, Tobias and Lengauer, Thomas and Rahnenfuhrer, Joerg and Roomp, Kirsten and Savenkov, Igor and Fischer, Roman and Hoffmann, Daniel and Selbig, Joachim and Korn, Klaus and Walter, Hauke and Berg, Thomas and Braun, Patrick and Faetkenheuer, Gerd and Oette, Mark and Rockstroh, Juergen and Kupfer, Bernd and Kaiser, Rolf and Daeumer, Martin}, title = {Computational methods for the design of effective therapies against drug resistant HIV strains}, year = {2005}, abstract = {The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data}, language = {en} } @article{JedrusikBodeStudenckaSmolkaetal.2013, author = {Jedrusik-Bode, Monika and Studencka, Maja and Smolka, Christian and Baumann, Tobias and Schmidt, Henning and Kampf, Jan and Paap, Franziska and Martin, Sophie and Tazi, Jamal and M{\"u}ller, Kristian M. and Kr{\"u}ger, Marcus and Braun, Thomas and Bober, Eva}, title = {The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals}, series = {Journal of cell science}, volume = {126}, journal = {Journal of cell science}, number = {22}, publisher = {Company of Biologists Limited}, address = {Cambridge}, issn = {0021-9533}, doi = {10.1242/jcs.130708}, pages = {5166 -- +}, year = {2013}, abstract = {SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.}, language = {en} } @article{StieglitzMirbabaieDeubeletal.2023, author = {Stieglitz, Stefan and Mirbabaie, Milad and Deubel, Annika and Braun, Lea-Marie and Kissmer, Tobias}, title = {The potential of digital nudging to bridge the gap between environmental attitude and behavior in the usage of smart home applications}, series = {International Journal of Information Management}, volume = {72}, journal = {International Journal of Information Management}, publisher = {Elsevier}, address = {Oxford}, issn = {0268-4012}, doi = {10.1016/j.ijinfomgt.2023.102665}, year = {2023}, abstract = {Despite energy efficiency measures, global energy demand has gradually increased due to global economic growth and changes in consumer behavior. Even if people are aware of the problem and want to change their energy consumption, they have difficulty acting on their attitudes. This is called the attitude-behavior gap. To narrow this gap and reduce energy consumption and CO2 emissions, behavioral interventions beyond technological advances must be considered. A promising intervention is nudging, which uses insights from behavioral economics to gently nudge individuals toward more sustainable choices. In this study, we investigate how modifying digital choice architectures with nudges can be used to influence consumer energy conservation behavior in smart home applications (SHAs). We conducted an online experiment with 391 participants to test the effectiveness of the following three digital nudges in an SHA: self-commitment, reminder, and social norm nudge. While the results of a structural equation model indicated no effect on bridging the gap between attitude and behavior, we found the potential to promote energy conservation with two nudge types. Thus, this paper makes substantial contribution to persuasive and information systems-enabled sustainability for a better world in the form of digital nudges for emerging technologies.}, language = {en} } @article{WirthHatterDrostetal.2015, author = {Wirth, Jonas and Hatter, Nino and Drost, Robert and Umbach, Tobias R. and Barja, Sara and Zastrow, Matthias and R{\"u}ck-Braun, Karola and Pascual, Jose Ignacio and Saalfrank, Peter and Franke, Katharina J.}, title = {Diarylethene Molecules on a Ag(111) Surface: Stability and Electron-Induced Switching}, series = {The journal of physical chemistry : C, Nanomaterials and interfaces}, volume = {119}, journal = {The journal of physical chemistry : C, Nanomaterials and interfaces}, number = {9}, publisher = {American Chemical Society}, address = {Washington}, issn = {1932-7447}, doi = {10.1021/jp5122036}, pages = {4874 -- 4883}, year = {2015}, abstract = {Diarylethene derivatives are photochromic molecular switches, undergoing a ring-opening/-closing reaction by illumination with light. The symmetry of the closed form is determined by the WoodWard Hoffinann rules according to which the reaction proceeds by corirotatory rotation -in that case. Here, we show by a cOrnbined approach of scanning tunneling microscopy (STM) and density functional theory (DFT) calculations that the Open isomer of 4,4'-(4,4'-(perfluorocydopent-1-ene-1,2-diyl)bis(5-methyl-thiophent-4,2,4-dipyridine) (PDTE) retains its open form upon adsorption on a Ag(111) surface. It caribe switched into a closed form, which we identify as the digrotatOly cydization product, by controlled manipulation 'With the STM tip, Evidence of an electric-field dependent switching-process 'is interpreted on the basis of a Simple electroStatic Model, which suggests that the reaction proceedS via an "upright" intermediate state. This pathway thus strongly differs from the switching reaction in solution.}, language = {en} } @inproceedings{KeilKonertDamniketal.2018, author = {Keil, Reinhard and Konert, Johannes and Damnik, Gregor and Gierl, Mark J. and Proske, Antje and K{\"o}rndle, Hermann and Narciss, Susanne and Wahl, Marina and H{\"o}lscher, Michael and Mariani, Ennio and Jaisli, Isabel and Tscherejkina, Anna and Morgiel, Anna and Moebert, Tobias and Herbstreit, Stephanie and M{\"a}ker, Daniela and Szalai, Cynthia and Braun, Iris and Kapp, Felix and Hara, Tenshi C. and Kubica, Tommy and Stumpf, Sarah}, title = {E-Learning Symposium 2018}, editor = {Lucke, Ulrike and Strickroth, Sven}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, doi = {10.25932/publishup-42071}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-420711}, pages = {71}, year = {2018}, abstract = {In den vergangenen Jahren sind viele E-Learning-Innovationen entstanden. Einige davon wurden auf den vergangenen E-Learning Symposien der Universit{\"a}t Potsdam pr{\"a}sentiert: Das erste E-Learning Symposium im Jahr 2012 konzentrierte sich auf unterschiedliche M{\"o}glichkeiten der Studierendenaktivierung und Lehrgestaltung. Das Symposium 2014 r{\"u}ckte vor allem die Studierenden ins Zentrum der Aufmerksamkeit. Im Jahr 2016 kam es durch das Zusammengehen des Symposiums mit der DeLFI-Tagung zu einer Fokussierung auf technische Innovationen. Doch was ist aus den Leuchtt{\"u}rmen von gestern geworden, und brauchen wir {\"u}berhaupt noch neue Leuchtt{\"u}rme? Das Symposium setzt sich in diesem Jahr unter dem Motto „Innovation und Nachhaltigkeit - (k)ein Gegensatz?" mit mediengest{\"u}tzten Lehr- und Lernprozessen im universit{\"a}ren Kontext auseinander und reflektiert aktuelle technische sowie didaktische Entwicklungen mit Blick auf deren mittel- bis langfristigen Einsatz in der Praxis. Dieser Tagungsband zum E-Learning Symposium 2018 an der Universit{\"a}t Potsdam beinhaltet eine Mischung von Forschungs- und Praxisbeitr{\"a}gen aus verschiedenen Fachdisziplinen und er{\"o}ffnet vielschichtige Perspektiven auf das Thema E-Learning. Dabei werden die Vielfalt der didaktischen Einsatzszenarien als auch die Potentiale von Werk-zeugen und Methoden der Informatik in ihrem Zusammenspiel beleuchtet. In seiner Keynote widmet sich Reinhard Keil dem Motto des Symposiums und geht der Nachhaltigkeit bei E-Learning-Projekten auf den Grund. Dabei analysiert und beleuchtet er anhand seiner {\"u}ber 15-j{\"a}hrigen Forschungspraxis die wichtigsten Wirkfaktoren und formuliert Empfehlungen zur Konzeption von E-Learning-Projekten. Im Gegensatz zu rein auf Kostenersparnis ausgerichteten (hochschul-)politischen Forderungen proklamiert er den Ansatz der hypothesengeleiteten Technikgestaltung, in der Nachhaltigkeit als Leitfrage oder Forschungsstrategie verstanden werden kann. In eine {\"a}hnliche Richtung geht der Beitrag von Iris Braun et al., die {\"u}ber Erfolgsfaktoren beim Einsatz von Audience Response Systemen in der universit{\"a}ren Lehre berichten. Ein weiteres aktuelles Thema, sowohl f{\"u}r die Bildungstechnologie als auch in den Bildungswissenschaften allgemein, ist die Kompetenzorientierung und -modellierung. Hier geht es darum (Probleml{\"o}se-)F{\"a}higkeiten gezielt zu beschreiben und in den Mittelpunkt der Lehre zu stellen. Johannes Konert stellt in einem eingeladenen Vortrag zwei Projekte vor, die den Prozess beginnend bei der Definition von Kompetenzen, deren Modellierung in einem semantischen maschinenlesbaren Format bis hin zur Erarbeitung von Methoden zur Kompetenzmessung und der elektronischen Zertifizierung aufzeigen. Dabei geht er auf technische M{\"o}glichkeiten, aber auch Grenzen ein. Auf einer spezifischeren Ebene besch{\"a}ftigt sich Sarah Stumpf mit digitalen bzw. mediendidaktischen Kompetenzen im Lehramtsstudium und stellt ein Framework f{\"u}r die F{\"o}rderung ebensolcher Kompetenzen bei angehenden Lehrkr{\"a}ften vor. Der Einsatz von E-Learning birgt noch einige Herausforderungen. Dabei geht es oft um die Verbindung von Didaktik und Technik, den Erhalt von Aufmerksamkeit oder den Aufwand f{\"u}r das Erstellen von interaktiven Lehr- und Lerninhalten. Drei Beitr{\"a}ge in diesem Tagungsband besch{\"a}ftigen sich mit dieser Thematik in unterschiedlichen Kontexten und zeigen Best-Practices und L{\"o}sungsans{\"a}tze auf: Der Beitrag von Martina Wahl und Michael H{\"o}lscher behandelt den besonderen Kontext von Blended Learning-Szenarien in berufsbegleitenden Studieng{\"a}ngen. Um die Ver{\"o}ffentlichung eines global frei verf{\"u}gbaren Onlinekurses abseits der großen MOOC Plattformen und den didaktischen Herausforderungen auch hinsichtlich der Motivation geht es im Beitrag von Ennio Marani und Isabel Jaisli. Schließlich schlagen Gregor Damnik et al. die automatische Erzeugung von Aufgaben zur Erh{\"o}hung von Interaktivit{\"a}t und Adaptivit{\"a}t in digitalen Lernressourcen vor, um den teilweise erheblichen Erstellungsaufwand zu reduzieren. Zum Thema E-Learning z{\"a}hlen auch immer mobile Apps bzw. Spiele. Gleich zwei Beitr{\"a}ge besch{\"a}ftigen sich mit dem Einsatz von E-Learning-Tools im Gesundheitskontext: Anna Tscherejkina und Anna Morgiel stellen in ihrem Beitrag Minispiele zum Training von sozio-emotionalen Kompetenzen f{\"u}r Menschen mit Autismus vor, und Stephanie Herbstreit et al. berichten vom Einsatz einer mobilen Lern-App zur Verbesserung von klinisch-praktischem Unterricht.}, language = {de} } @phdthesis{Braun2023, author = {Braun, Tobias}, title = {Recurrences in past climates}, doi = {10.25932/publishup-58690}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-586900}, school = {Universit{\"a}t Potsdam}, pages = {xxviii, 251}, year = {2023}, abstract = {Our ability to predict the state of a system relies on its tendency to recur to states it has visited before. Recurrence also pervades common intuitions about the systems we are most familiar with: daily routines, social rituals and the return of the seasons are just a few relatable examples. To this end, recurrence plots (RP) provide a systematic framework to quantify the recurrence of states. Despite their conceptual simplicity, they are a versatile tool in the study of observational data. The global climate is a complex system for which an understanding based on observational data is not only of academical relevance, but vital for the predurance of human societies within the planetary boundaries. Contextualizing current global climate change, however, requires observational data far beyond the instrumental period. The palaeoclimate record offers a valuable archive of proxy data but demands methodological approaches that adequately address its complexities. In this regard, the following dissertation aims at devising novel and further developing existing methods in the framework of recurrence analysis (RA). The proposed research questions focus on using RA to capture scale-dependent properties in nonlinear time series and tailoring recurrence quantification analysis (RQA) to characterize seasonal variability in palaeoclimate records ('Palaeoseasonality'). In the first part of this thesis, we focus on the methodological development of novel approaches in RA. The predictability of nonlinear (palaeo)climate time series is limited by abrupt transitions between regimes that exhibit entirely different dynamical complexity (e.g. crossing of 'tipping points'). These possibly depend on characteristic time scales. RPs are well-established for detecting transitions and capture scale-dependencies, yet few approaches have combined both aspects. We apply existing concepts from the study of self-similar textures to RPs to detect abrupt transitions, considering the most relevant time scales. This combination of methods further results in the definition of a novel recurrence based nonlinear dependence measure. Quantifying lagged interactions between multiple variables is a common problem, especially in the characterization of high-dimensional complex systems. The proposed 'recurrence flow' measure of nonlinear dependence offers an elegant way to characterize such couplings. For spatially extended complex systems, the coupled dynamics of local variables result in the emergence of spatial patterns. These patterns tend to recur in time. Based on this observation, we propose a novel method that entails dynamically distinct regimes of atmospheric circulation based on their recurrent spatial patterns. Bridging the two parts of this dissertation, we next turn to methodological advances of RA for the study of Palaeoseasonality. Observational series of palaeoclimate 'proxy' records involve inherent limitations, such as irregular temporal sampling. We reveal biases in the RQA of time series with a non-stationary sampling rate and propose a correction scheme. In the second part of this thesis, we proceed with applications in Palaeoseasonality. A review of common and promising time series analysis methods shows that numerous valuable tools exist, but their sound application requires adaptions to archive-specific limitations and consolidating transdisciplinary knowledge. Next, we study stalagmite proxy records from the Central Pacific as sensitive recorders of mid-Holocene El Ni{\~n}o-Southern Oscillation (ENSO) dynamics. The records' remarkably high temporal resolution allows to draw links between ENSO and seasonal dynamics, quantified by RA. The final study presented here examines how seasonal predictability could play a role for the stability of agricultural societies. The Classic Maya underwent a period of sociopolitical disintegration that has been linked to drought events. Based on seasonally resolved stable isotope records from Yok Balum cave in Belize, we propose a measure of seasonal predictability. It unveils the potential role declining seasonal predictability could have played in destabilizing agricultural and sociopolitical systems of Classic Maya populations. The methodological approaches and applications presented in this work reveal multiple exciting future research avenues, both for RA and the study of Palaeoseasonality.}, language = {en} } @article{StieglitzMirbabaieDeubeletal.2024, author = {Stieglitz, Stefan and Mirbabaie, Milad and Deubel, Annika and Braun, Lea-Marie and Kissmer, Tobias}, title = {Corrigendum to "The potential of digital nudging to bridge the gap between environmental attitude and behavior in the usage of smart home applications" [International Journal of Information Management 72 (2023) 102665]}, series = {International journal of information management}, volume = {76}, journal = {International journal of information management}, publisher = {Elsevier}, address = {Oxford}, issn = {0268-4012}, doi = {10.1016/j.ijinfomgt.2024.102774}, pages = {2}, year = {2024}, abstract = {We would like to inform the readers and editors of the journal that we have discovered some errors in the references of our paper. These errors were brought to our attention by a reader who noticed some inconsistencies between the citations in the text and the bibliography. Upon further investigation, we realized that our literature management software had mistakenly linked some of the references to wrong or non-existent sources. We apologize for this oversight and assure you that it did not affect the validity or quality of our arguments and results, which were based on the correct sources. Below you find a list of the incorrect references along with their corresponding correct ones. We hope that this correction statement will clarify any confusion or misunderstanding that may have arisen from this mistake. The authors would like to apologise for any inconvenience caused.}, language = {en} }