@article{JonscherFlemmingSchmittetal.2018,
  author    = {Jonscher, Ernst and Flemming, Sven and Schmitt, Marius and Sabitzki, Ricarda and Reichard, Nick and Birnbaum, Jakob and Bergmann, B{\"a}rbel and H{\"o}hn, Katharina and Spielmann, Tobias},
  title     = {PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites},
  series = {Cell host \& microbe},
  volume    = {25},
  journal   = {Cell host \& microbe},
  number    = {1},
  publisher = {Cell Press},
  address   = {Cambridge},
  issn      = {1931-3128},
  doi       = {10.1016/j.chom.2018.11.010},
  pages     = {166 -- 173},
  year      = {2018},
  abstract  = {During development in human erythrocytes, the malaria parasite Plasmodium falciparum internalizes a large part of the cellular content of the host cell. The internalized cytosol, consisting largely of hemoglobin, is transported to the parasite's food vacuole where it is degraded, providing nutrients and space for growth. This host cell cytosol uptake (HCCU) is crucial for parasite survival but the parasite proteins mediating this process remain obscure. Here, we identify P. falciparum VPS45 as an essential factor in HCCU. Conditional inactivation of PfVPS45 led to an accumulation of host cell cytosol-filled vesicles within the parasite and inhibited the delivery of hemoglobin to the parasite's digestive vacuole, resulting in arrested parasite growth. A proportion of these HCCU vesicle intermediates was positive for phosphatidylinositol 3-phosphate, suggesting endosomal characteristics. Thus PfVPS45 provides insight into the elusive machinery of the ingestion pathway in a parasite that contains an endolysosomal system heavily repurposed for protein secretion.},
  language  = {en}
}
@article{HagenBaumannWagneretal.2014,
  author    = {Hagen, Sven and Baumann, Tobias and Wagner, Hanna J. and Morath, Volker and Kaufmann, Beate and Fischer, Adrian and Bergmann, Stefan and Schindler, Patrick and Arndt, Katja Maren and Mueller, Kristian M.},
  title     = {Modular adeno-associated virus (rAAV) vectors used for cellular virus-directed enzyme prodrug therapy},
  series = {Scientific reports},
  volume    = {4},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/srep03759},
  pages     = {11},
  year      = {2014},
  abstract  = {The pre-clinical and clinical development of viral vehicles for gene transfer increased in recent years, and a recombinant adeno-associated virus (rAAV) drug took center stage upon approval in the European Union. However, lack of standardization, inefficient purification methods and complicated retargeting limit general usability. We address these obstacles by fusing rAAV-2 capsids with two modular targeting molecules (DARPin or Affibody) specific for a cancer cell-surface marker (EGFR) while simultaneously including an affinity tag (His-tag) in a surface-exposed loop. Equipping these particles with genes coding for prodrug converting enzymes (thymidine kinase or cytosine deaminase) we demonstrate tumor marker specific transduction and prodrug-dependent apoptosis of cancer cells. Coding terminal and loop modifications in one gene enabled specific and scalable purification. Our genetic parts for viral production adhere to a standardized cloning strategy facilitating rapid prototyping of virus directed enzyme prodrug therapy (VDEPT).},
  language  = {en}
}
@article{DeyBergmannCuellarCamachoetal.2018,
  author    = {Dey, Pradip and Bergmann, Tobias and Cuellar-Camacho, Jose Luis and Ehrmann, Svenja and Chowdhury, Mohammad Suman and Zhang, Minze and Dahmani, Ismail and Haag, Rainer and Azad, Walid},
  title     = {Multivalent flexible nanogels exhibit broad-spectrum antiviral activity by blocking virus entry},
  series = {ACS nano},
  volume    = {12},
  journal   = {ACS nano},
  number    = {7},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1936-0851},
  doi       = {10.1021/acsnano.8b01616},
  pages     = {6429 -- 6442},
  year      = {2018},
  abstract  = {The entry process of viruses into host cells is complex and involves stable but transient multivalent interactions with different cell surface receptors. The initial contact of several viruses begins with attachment to heparan sulfate (HS) proteoglycans on the cell surface, which results in a cascade of events that end up with virus entry. The development of antiviral agents based on multivalent interactions to shield virus particles and block initial interactions with cellular receptors has attracted attention in antiviral research. Here, we designed nanogels with different degrees of flexibility based on dendritic polyglycerol sulfate to mimic cellular HS. The designed nanogels are nontoxic and broad-spectrum, can multivalently interact with viral glycoproteins, shield virus surfaces, and efficiently block infection. We also visualized virus-nanogel interactions as well as the uptake of nanogels by the cells through clathrin-mediated endocytosis using confocal microscopy. As many human viruses attach to the cells through HS moieties, we introduce our flexible nanogels as robust inhibitors for these viruses.},
  language  = {en}
}
@article{AmbergausdemMooreBekketal.2022,
  author    = {Amberg, Maximilian and aus dem Moore, Nils and Bekk, Anke and Bergmann, Tobias and Edenhofer, Ottmar and Flachsland, Christian and George, Jan and Haywood, Luke and Heinemann, Maik and Held, Anne and Kalkuhl, Matthias and Kellner, Maximilian and Koch, Nicolas and Luderer, Gunnar and Meyer, Henrika and Nikodinoska, Dragana and Pahle, Michael and Roolfs, Christina and Schill, Wolf-Peter},
  title     = {Reformoptionen f{\"u}r ein nachhaltiges Steuer- und Abgabensystem},
  series = {Perspektiven der Wirtschaftspolitik},
  volume    = {23},
  journal   = {Perspektiven der Wirtschaftspolitik},
  number    = {3},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {1465-6493},
  doi       = {10.1515/pwp-2021-0051},
  pages     = {165 -- 199},
  year      = {2022},
  abstract  = {Steuern und Abgaben auf Produkte oder Verbrauch mit gesellschaftlichen Folgekosten (externe Kosten) - sogenannte Pigou- oder Lenkungssteuern - sind ein gesellschaftliches „Win-Win-Instrument". Sie verbessern die Wohlfahrt und sch{\"u}tzen gleichzeitig die Umwelt und das Klima. Dies wird erreicht, indem umweltsch{\"a}digende Aktivit{\"a}ten einen Preis bekommen, der m{\"o}glichst exakt der H{\"o}he des Schadens entspricht. Eine konsequente Bepreisung der externen Kosten nach diesem Prinzip k{\"o}nnte in Deutschland erhebliche zus{\"a}tzliche Einnahmen erbringen: Basierend auf bisherigen Studien zu externen Kosten w{\"a}ren zus{\"a}tzliche Einnahmen in der Gr{\"o}ßenordnung von 348 bis 564 Milliarden Euro pro Jahr (44 bis 71 Prozent der gesamten Steuereinnahmen) m{\"o}glich. Die Autoren warnen allerdings, dass die Bezifferung der externen Kosten mit erheblichen Unsicherheiten verbunden ist. Damit Lenkungssteuern und -abgaben ihre positiven Lenkungs- und Wohlstandseffekte voll entfalten k{\"o}nnen, seien zudem institutionelle Reformen notwendig.},
  language  = {de}
}
@techreport{KalkuhlFlachslandKnopfetal.2022,
  type      = {Working Paper},
  author    = {Kalkuhl, Matthias and Flachsland, Christian and Knopf, Brigitte and Amberg, Maximilian and Bergmann, Tobias and Kellner, Maximilian and St{\"u}ber, Sophia and Haywood, Luke and Roolfs, Christina and Edenhofer, Ottmar},
  title     = {Effects of the energy price crisis on households in Germany},
  publisher = {Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH},
  address   = {Berlin},
  pages     = {35},
  year      = {2022},
  language  = {en}
}
@techreport{KalkuhlFlachslandKnopfetal.2022,
  type      = {Working Paper},
  author    = {Kalkuhl, Matthias and Flachsland, Christian and Knopf, Brigitte and Amberg, Maximilian and Bergmann, Tobias and Kellner, Maximilian and St{\"u}ber, Sophia and Haywood, Luke and Roolfs, Christina and Edenhofer, Ottmar},
  title     = {Auswirkungen der Energiepreiskrise auf Haushalte in Deutschland},
  publisher = {Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH},
  address   = {Berlin},
  pages     = {37},
  year      = {2022},
  language  = {de}
}
@techreport{KalkuhlAmbergBergmannetal.2022,
  type      = {Working Paper},
  author    = {Kalkuhl, Matthias and Amberg, Maximilian and Bergmann, Tobias and Knopf, Brigitte and Edenhofer, Ottmar},
  title     = {Gaspreisdeckel, Mehrwertsteuersenkung, Energiepauschale},
  publisher = {Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH},
  address   = {Berlin},
  pages     = {23},
  year      = {2022},
  language  = {de}
}
@techreport{KellnerAmbergBergmannetal.2022,
  type      = {Working Paper},
  author    = {Kellner, Maximilian and Amberg, Maximilian and Bergmann, Tobias and Roolfs, Christina and Kalkuhl, Matthias},
  title     = {Entlastungspakete f{\"u}r Energiepreisanstiege},
  publisher = {Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH},
  address   = {Berlin},
  doi       = {10.5281/zenodo.6617130},
  pages     = {23},
  year      = {2022},
  language  = {de}
}
@article{SchwingshacklRuzanskaAntonetal.2018,
  author    = {Schwingshackl, Lukas and Ruzanska, Ulrike Alexandra and Anton, Verena and Wallroth, Raphael and Ohla, Kathrin and Knueppel, Sven and Schulze, Matthias Bernd and Pischon, Tobias and Deutschbein, Johannes and Schenk, Liane and Warschburger, Petra and Harttig, Ulrich and Boeing, Heiner and Bergmann, Manuela M.},
  title     = {The NutriAct Family Study: a web-based prospective study on the epidemiological, psychological and sociological basis of food choice},
  series = {BMC public health},
  volume    = {18},
  journal   = {BMC public health},
  publisher = {BMC},
  address   = {London},
  issn      = {1471-2458},
  doi       = {10.1186/s12889-018-5814-x},
  pages     = {12},
  year      = {2018},
  abstract  = {Background: Most studies on food choice have been focussing on the individual level but familial aspects may also play an important role. This paper reports of a novel study that will focus on the familial aspects of the formation of food choice among men and women aged 50-70 years by recruiting spouses and siblings (NutriAct Family Study; NFS). Discussion: Until August 4th 2017, 4783 EPIC-Participants were contacted by mail of which 446 persons recruited 2 to 5 family members (including themselves) resulting in 1032 participants, of whom 82\% had started answering or already completed the questionnaires. Of the 4337 remaining EPIC-participants who had been contacted, 1040 (24\%) did not respond at all, and 3297 (76\%) responded but declined, in 51\% of the cases because of the request to recruit at least 2 family members in the respective age range. The developed recruitment procedures and web-based methods of data collection are capable to generate the required study population including the data on individual and inter-personal determinants which will be linkable to food choice. The information on familial links among the study participants will show the role of familial traits in midlife for the adoption of food choices supporting healthy aging.},
  language  = {en}
}