@article{HartmannHelbigBiernackaetal.2019,
  author    = {Hartmann, Niklas K. and Helbig, Kerstin and Biernacka, Katarzyna and Buchholz, Petra and Dolzycka, Dominika and Hartmann, Thomas and Hiemenz, Bea and Jacob, Boris and Kuberek, Monika and Weiß, Nadin and Dreyer, Malte},
  title     = {L{\"o}sungen und Leitf{\"a}den f{\"u}r das institutionelle Forschungsdatenmanagement},
  series = {o-bib Das offene Bibliotheksjournal},
  volume    = {6},
  journal   = {o-bib Das offene Bibliotheksjournal},
  number    = {3},
  publisher = {VDB - Verein Deutscher Bibliothekarinnen und Bibliothekare e.V.},
  address   = {Erlangen},
  issn      = {2363-9814},
  doi       = {10.5282/o-bib/2019H3S21-39},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472370},
  pages     = {21 -- 39},
  year      = {2019},
  abstract  = {Hochschulen und deren Zentraleinrichtungen besch{\"a}ftigen sich zunehmend mit dem Thema Forschungsdatenmanagement (FDM), um ihre Forschenden ad{\"a}quat zu unterst{\"u}tzen. Nicht zuletzt aufgrund neuer Verlags- und F{\"o}rderanforderungen w{\"u}nschen sich Forschende Beratung und Orientierung, wie sie mit ihren Forschungsdaten umgehen sollen. Damit Hochschulen schnell und nachhaltig L{\"o}sungen zum institutionellen FDM etablieren k{\"o}nnen, haben f{\"u}nf Berliner und Brandenburger Universit{\"a}ten im gemeinsamen Verbundvorhaben FDMentor mit F{\"o}rderung des Bundesministeriums f{\"u}r Bildung und Forschung (BMBF) entsprechende Leitf{\"a}den und Werkzeuge erarbeitet. Die innerhalb von zwei Jahren (2017-2019) entstandenen Ergebnisse in den Bereichen Strategieentwicklung, Forschungsdaten-Policy, rechtliche Aspekte und Kompetenzausbau finden {\"u}ber das Verbundprojekt hinaus ihre Anwendung.},
  language  = {de}
}
@article{HartmannWaiHuetal.2016,
  author    = {Hartmann, Bianca and Wai, Timothy and Hu, Hao and MacVicar, Thomas and Musante, Luciana and Fischer-Zirnsak, Bj{\"o}rn and Stenzel, Werner and Gr{\"a}f, Ralph and van den Heuvel, Lambert and Ropers, Hans-Hilger and Wienker, Thomas F. and H{\"u}bner, Christoph and Langer, Thomas and Kaindl, Angela M.},
  title     = {Homozygous YME1L1 Mutation Causes Mitochondriopathy with Optic Atrophy and Mitochondrial Network Fragmentation},
  series = {eLife},
  volume    = {5},
  journal   = {eLife},
  publisher = {eLife Sciences Publications},
  address   = {Cambridge},
  issn      = {2050-084X},
  doi       = {10.7554/eLife.16078},
  pages     = {1156 -- 1165},
  year      = {2016},
  abstract  = {Mitochondriopathies often present clinically as multisystemic disorders of primarily high-energy consuming organs. Assembly, turnover, and surveillance of mitochondrial proteins are essential for mitochondrial function and a key task of AAA family members of metalloproteases. We identified a homozygous mutation in the nuclear encoded mitochondrial escape 1-like 1 gene YME1L1, member of the AAA protease family, as a cause of a novel mitochondriopathy in a consanguineous pedigree of Saudi Arabian descent. The homozygous missense mutation, located in a highly conserved region in the mitochondrial pre-sequence, inhibits cleavage of YME1L1 by the mitochondrial processing peptidase, which culminates in the rapid degradation of YME1L1 precursor protein. Impaired YME1L1 function causes a proliferation defect and mitochondrial network fragmentation due to abnormal processing of OPA1. Our results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans.},
  language  = {en}
}
@article{HilgersHartmannHofreiteretal.2018,
  author    = {Hilgers, Leon and Hartmann, Stefanie and Hofreiter, Michael and von Rintelen, Thomas},
  title     = {Novel Genes, Ancient Genes, and Gene Co-Option Contributed o the Genetic Basis of the Radula, a Molluscan Innovation},
  series = {Molecular biology and evolution},
  volume    = {35},
  journal   = {Molecular biology and evolution},
  number    = {7},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0737-4038},
  doi       = {10.1093/molbev/msy052},
  pages     = {1638 -- 1652},
  year      = {2018},
  abstract  = {The radula is the central foraging organ and apomorphy of the Mollusca. However, in contrast to other innovations, including the mollusk shell, genetic underpinnings of radula formation remain virtually unknown. Here, we present the first radula formative tissue transcriptome using the viviparous freshwater snail Tylomelania sarasinorum and compare it to foot tissue and the shell-building mantle of the same species. We combine differential expression, functional enrichment, and phylostratigraphic analyses to identify both specific and shared genetic underpinnings of the three tissues as well as their dominant functions and evolutionary origins. Gene expression of radula formative tissue is very distinct, but nevertheless more similar to mantle than to foot. Generally, the genetic bases of both radula and shell formation were shaped by novel orchestration of preexisting genes and continuous evolution of novel genes. A significantly increased proportion of radula-specific genes originated since the origin of stem-mollusks, indicating that novel genes were especially important for radula evolution. Genes with radula-specific expression in our study are frequently also expressed during the formation of other lophotrochozoan hard structures, like chaetae (hes1, arx), spicules (gbx), and shells of mollusks (gbx, heph) and brachiopods (heph), suggesting gene co-option for hard structure formation. Finally, a Lophotrochozoa-specific chitin synthase with a myosin motor domain (CS-MD), which is expressed during mollusk and brachiopod shell formation, had radula-specific expression in our study. CS-MD potentially facilitated the construction of complex chitinous structures and points at the potential of molecular novelties to promote the evolution of different morphological innovations.},
  language  = {en}
}
@misc{VossMeyerSchwonbecketal.2005,
  author    = {Voss, Henning and Meyer, Jeannette and Schwonbeck, Susanne and Fritsche, Immo and Hartmann, Bernhard and Wegwarth, Odette and Friedrich, Anke and Buchheister-Knappe, Stefanie and Marwan, Norbert and Bandau, Anja and Bullinger, Hans-J{\"o}rg and Weith, Thomas},
  title     = {Portal alumni},
  series = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
  volume    = {2005},
  journal   = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
  number    = {3},
  organization    = {Stabsstelle Studierendenmarketing/Alumniprogramm Im Auftrag der Pr{\"a}sidentin der Universit{\"a}t Potsdam},
  doi       = {10.25932/publishup-48160},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-481608},
  pages     = {58},
  year      = {2005},
  abstract  = {Liebe Leserin, lieber Leser, erforschen, was die Welt im Innersten zusammenh{\"a}lt- das ist f{\"u}r viele Studierende ein Traum. Doch welche Opfer muss man bringen, um ihn zu verwirklichen? Welche Bemfsperspektive hat der Bemf Forscher heute noch? Auch viele Absolventen der Universit{\"a}t Potsdam m{\"u}ssen sich diese Fragen beantworten. Zu welchen Antworten einige dabei gekommen sind und welche Probleme sie zu bew{\"a}ltigen haben, vom Spaß am Forschen und von Zukunfts{\"a}ngsten berichten sie in der Rubrik "Forscherkarrieren". Gelder f{\"u}r die Forschung fließen in Deutschland zu sp{\"a}rlich, verglichen mit anderen f{\"u}hrenden Industrienationen. So sind die Bedingungen f{\"u}r Forscher hierzulande nicht die besten. Manchen jungen Wissenschaftler zieht es- mitunter notgedrungen- ins Ausland. Wie Deutschland dadurch seine ZukunftsHihigkeit riskiert, thematisiert der Pr{\"a}sident der Fraunhofer-Gesellschaft, Prof. Dr. Hans-J{\"o}rg Bullinger, in der Rubrik "wissenstransfer". Auch die Universit{\"a}t ist kein Garant f{\"u}r eine gesicherte Zukunft in der Forschung. Wer sechs Jahre nach der Promotion den Sprung zur Professur nicht geschafft hat, geht einer ungewissen Zukunft als Privatdozent entgegen. Seit einigen Jahren gibt es neben der Habilitation noch einen zweiten Weg zur Professur- die Juniorprofessur. Auch an der Universit{\"a}t Potsdam gibt es seit 2002 Juniorprofessoren, von denen die ersten jetzt evaluiert wurden. N{\"a}heres dazu finden Sie ebenfalls in der Rubrik "wissenstransfer". Wer noch nach einer Finanzierungsm{\"o}glichkeit f{\"u}r seine Promotion sucht, findet Tipps in der Rubrik "wegweiser". Die Redaktion w{\"u}nscht Ihnen viel Vergn{\"u}gen beim Lesen von Portal alumni und freut sich auf zahlreiche Leserbriefe.},
  language  = {de}
}
@article{HilgersHartmannPfaenderetal.2022,
  author    = {Hilgers, Leon and Hartmann, Stefanie and Pfaender, Jobst and Lentge-Maass, Nora and Marwoto, Ristiyanti M. and von Rintelen, Thomas and Hofreiter, Michael},
  title     = {Evolutionary divergence and radula diversification in two ecomorphs from an adaptive radiation of freshwater snails},
  series = {Genes},
  volume    = {13},
  journal   = {Genes},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4425},
  doi       = {10.3390/genes13061029},
  pages     = {16},
  year      = {2022},
  abstract  = {(1) Background: Adaptive diversification of complex traits plays a pivotal role in the evolution of organismal diversity. In the freshwater snail genus Tylomelania, adaptive radiations were likely promoted by trophic specialization via diversification of their key foraging organ, the radula. (2) Methods: To investigate the molecular basis of radula diversification and its contribution to lineage divergence, we used tissue-specific transcriptomes of two sympatric Tylomelania sarasinorum ecomorphs. (3) Results: We show that ecomorphs are genetically divergent lineages with habitat-correlated abundances. Sequence divergence and the proportion of highly differentially expressed genes are significantly higher between radula transcriptomes compared to the mantle and foot. However, the same is not true when all differentially expressed genes or only non-synonymous SNPs are considered. Finally, putative homologs of some candidate genes for radula diversification (hh, arx, gbb) were also found to contribute to trophic specialization in cichlids and Darwin's finches. (4) Conclusions: Our results are in line with diversifying selection on the radula driving Tylomelania ecomorph divergence and indicate that some molecular pathways may be especially prone to adaptive diversification, even across phylogenetically distant animal groups.},
  language  = {en}
}