@article{MaazKrueckenBluemkeetal.2018,
  author    = {Maaz, Denny and Kr{\"u}cken, Juergen and Bl{\"u}mke, Julia and Richter, Dania and McKay-Demeler, Janina and Matuschka, Franz-Rainer and Hartmann, Susanne and von Samson-Himmelstjerna, Georg},
  title     = {Factors associated with diversity, quantity and zoonotic potential of ectoparasites on urban mice and voles},
  series = {PLoS one},
  volume    = {13},
  journal   = {PLoS one},
  number    = {6},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0199385},
  pages     = {32},
  year      = {2018},
  abstract  = {Wild rodents are important hosts for tick larvae but co-infestations with other mites and insects are largely neglected. Small rodents were trapped at four study sites in Berlin, Germany, to quantify their ectoparasite diversity. Host-specific, spatial and temporal occurrence of ectoparasites was determined to assess their influence on direct and indirect zoonotic risk due to mice and voles in an urban agglomeration. Rodent-associated arthropods were diverse, including 63 species observed on six host species with an overall prevalence of 99\%. The tick Ixodes ricinus was the most prevalent species, found on 56\% of the rodents. The trapping location clearly affected the presence of different rodent species and, therefore, the occurrence of particular host-specific parasites. In Berlin, fewer temporary and periodic parasite species as well as non-parasitic species (fleas, chiggers and nidicolous Gamasina) were detected than reported from rural areas. In addition, abundance of parasites with low host-specificity (ticks, fleas and chiggers) apparently decreased with increasing landscape fragmentation associated with a gradient of urbanisation. In contrast, stationary ectoparasites, closely adapted to the rodent host, such as the fur mites Myobiidae and Listrophoridae, were most abundant at the two urban sites. A direct zoonotic risk of infection for people may only be posed by Nosopsyllus fasciatus fleas, which were prevalent even in the city centre. More importantly, peridomestic rodents clearly supported the life cycle of ticks in the city as hosts for their subadult stages. In addition to trapping location, season, host species, body condition and host sex, infestation with fleas, gamasid Laelapidae mites and prostigmatic Myobiidae mites were associated with significantly altered abundance of I. ricinus larvae on mice and voles. Whether this is caused by predation, grooming behaviour or interaction with the host immune system is unclear. The present study constitutes a basis to identify interactions and vector function of rodent-associated arthropods and their potential impact on zoonotic diseases.},
  language  = {en}
}
@article{MaazRauschRichteretal.2016,
  author    = {Maaz, Denny and Rausch, Sebastian and Richter, Dania and Kruecken, Juergen and Kuehl, Anja A. and Demeler, Janina and Bluemke, Julia and Matuschka, Franz-Rainer and von Samson-Himmelstjerna, Georg and Hartmann, Susanne},
  title     = {Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes},
  series = {Infection and immunity},
  volume    = {84},
  journal   = {Infection and immunity},
  publisher = {American Society for Microbiology},
  address   = {Washington},
  issn      = {0019-9567},
  doi       = {10.1128/IAI.01309-15},
  pages     = {1274 -- 1286},
  year      = {2016},
  abstract  = {Small rodents serve as reservoir hosts for tick-borne pathogens, such as the spirochetes causing Lyme disease. Whether natural coinfections with other macroparasites alter the success of tick feeding, antitick immunity, and the host's reservoir competence for tick-borne pathogens remains to be determined. In a parasitological survey of wild mice in Berlin, Germany, approximately 40\% of Ixodes ricinus-infested animals simultaneously harbored a nematode of the genus Heligmosomoides. We therefore aimed to analyze the immunological impact of the nematode/tick coinfection as well as its effect on the tick-borne pathogen Borrelia afzelii. Hosts experimentally coinfected with Heligmosomoides polygyrus and larval/nymphal I. ricinus ticks developed substantially stronger systemic type 2 T helper cell (Th2) responses, on the basis of the levels of GATA-3 and interleukin-13 expression, than mice infected with a single pathogen. During repeated larval infestations, however, anti-tick Th2 reactivity and an observed partial immunity to tick feeding were unaffected by concurrent nematode infections. Importantly, the strong systemic Th2 immune response in coinfected mice did not affect susceptibility to tick-borne B. afzelii. An observed trend for decreased local and systemic Th1 reactivity against B. afzelii in coinfected mice did not result in a higher spirochete burden, nor did it facilitate bacterial dissemination or induce signs of immunopathology. Hence, this study indicates that strong systemic Th2 responses in nematode/tick-coinfected house mice do not affect the success of tick feeding and the control of the causative agent of Lyme disease.},
  language  = {en}
}
@misc{MaazKrueckenBluemkeetal.2018,
  author    = {Maaz, Denny and Kr{\"u}cken, J{\"u}rgen and Bl{\"u}mke, Julia and Richter, Dania and McKay-Demeler, Janina and Matuschka, Franz-Rainer and Hartmann, Susanne and von Samson-Himmelstjerna, Georg},
  title     = {Factors associated with diversity, quantity and zoonotic potential of ectoparasites on urban mice and voles},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {685},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42684},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-426843},
  pages     = {32},
  year      = {2018},
  abstract  = {Wild rodents are important hosts for tick larvae but co-infestations with other mites and insects are largely neglected. Small rodents were trapped at four study sites in Berlin, Germany, to quantify their ectoparasite diversity. Host-specific, spatial and temporal occurrence of ectoparasites was determined to assess their influence on direct and indirect zoonotic risk due to mice and voles in an urban agglomeration. Rodent-associated arthropods were diverse, including 63 species observed on six host species with an overall prevalence of 99\%. The tick Ixodes ricinus was the most prevalent species, found on 56\% of the rodents. The trapping location clearly affected the presence of different rodent species and, therefore, the occurrence of particular host-specific parasites. In Berlin, fewer temporary and periodic parasite species as well as non-parasitic species (fleas, chiggers and nidicolous Gamasina) were detected than reported from rural areas. In addition, abundance of parasites with low host-specificity (ticks, fleas and chiggers) apparently decreased with increasing landscape fragmentation associated with a gradient of urbanisation. In contrast, stationary ectoparasites, closely adapted to the rodent host, such as the fur mites Myobiidae and Listrophoridae, were most abundant at the two urban sites. A direct zoonotic risk of infection for people may only be posed by Nosopsyllus fasciatus fleas, which were prevalent even in the city centre. More importantly, peridomestic rodents clearly supported the life cycle of ticks in the city as hosts for their subadult stages. In addition to trapping location, season, host species, body condition and host sex, infestation with fleas, gamasid Laelapidae mites and prostigmatic Myobiidae mites were associated with significantly altered abundance of I. ricinus larvae on mice and voles. Whether this is caused by predation, grooming behaviour or interaction with the host immune system is unclear. The present study constitutes a basis to identify interactions and vector function of rodent-associated arthropods and their potential impact on zoonotic diseases.},
  language  = {en}
}
@article{KachlerBailerHeimetal.2017,
  author    = {Kachler, Katerina and Bailer, Maximilian and Heim, Lisanne and Schumacher, Fabian and Reichel, Martin and Holzinger, Corinna D. and Trump, Sonja and Mittler, Susanne and Monti, Juliana and Trufa, Denis I. and Rieker, Ralf J. and Hartmann, Arndt and Sirbu, Horia and Kleuser, Burkhard and Kornhuber, Johannes and Finotto, Susetta},
  title     = {Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma},
  series = {Cancer research},
  volume    = {77},
  journal   = {Cancer research},
  number    = {21},
  publisher = {American Association for Cancer Research},
  address   = {Philadelphia},
  issn      = {0008-5472},
  doi       = {10.1158/0008-5472.CAN-16-3313},
  pages     = {5963 -- 5976},
  year      = {2017},
  abstract  = {The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal therapeutic target. In this study, we demonstrate elevated ASM activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC). RNAi-mediated attenuation of SMPD1 in human NSCLC cells rendered them resistant to serum starvation-induced apoptosis. In a murine model of lung adenocarcinoma, ASM deficiency reduced tumor development in a manner associated with significant enhancement of Th1-mediated and cytotoxic T-cell-mediated antitumor immunity. Our findings indicate that targeting ASM in NSCLC can act by tumor cell-intrinsic and-extrinsic mechanisms to suppress tumor cell growth, most notably by enabling an effective antitumor immune response by the host. (C) 2017 AACR.},
  language  = {en}
}
@misc{VossMeyerSchwonbecketal.2005,
  author    = {Voss, Henning and Meyer, Jeannette and Schwonbeck, Susanne and Fritsche, Immo and Hartmann, Bernhard and Wegwarth, Odette and Friedrich, Anke and Buchheister-Knappe, Stefanie and Marwan, Norbert and Bandau, Anja and Bullinger, Hans-J{\"o}rg and Weith, Thomas},
  title     = {Portal alumni},
  series = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
  volume    = {2005},
  journal   = {Das Ehemaligen-Magazin der Universit{\"a}t Potsdam},
  number    = {3},
  organization    = {Stabsstelle Studierendenmarketing/Alumniprogramm Im Auftrag der Pr{\"a}sidentin der Universit{\"a}t Potsdam},
  doi       = {10.25932/publishup-48160},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-481608},
  pages     = {58},
  year      = {2005},
  abstract  = {Liebe Leserin, lieber Leser, erforschen, was die Welt im Innersten zusammenh{\"a}lt- das ist f{\"u}r viele Studierende ein Traum. Doch welche Opfer muss man bringen, um ihn zu verwirklichen? Welche Bemfsperspektive hat der Bemf Forscher heute noch? Auch viele Absolventen der Universit{\"a}t Potsdam m{\"u}ssen sich diese Fragen beantworten. Zu welchen Antworten einige dabei gekommen sind und welche Probleme sie zu bew{\"a}ltigen haben, vom Spaß am Forschen und von Zukunfts{\"a}ngsten berichten sie in der Rubrik "Forscherkarrieren". Gelder f{\"u}r die Forschung fließen in Deutschland zu sp{\"a}rlich, verglichen mit anderen f{\"u}hrenden Industrienationen. So sind die Bedingungen f{\"u}r Forscher hierzulande nicht die besten. Manchen jungen Wissenschaftler zieht es- mitunter notgedrungen- ins Ausland. Wie Deutschland dadurch seine ZukunftsHihigkeit riskiert, thematisiert der Pr{\"a}sident der Fraunhofer-Gesellschaft, Prof. Dr. Hans-J{\"o}rg Bullinger, in der Rubrik "wissenstransfer". Auch die Universit{\"a}t ist kein Garant f{\"u}r eine gesicherte Zukunft in der Forschung. Wer sechs Jahre nach der Promotion den Sprung zur Professur nicht geschafft hat, geht einer ungewissen Zukunft als Privatdozent entgegen. Seit einigen Jahren gibt es neben der Habilitation noch einen zweiten Weg zur Professur- die Juniorprofessur. Auch an der Universit{\"a}t Potsdam gibt es seit 2002 Juniorprofessoren, von denen die ersten jetzt evaluiert wurden. N{\"a}heres dazu finden Sie ebenfalls in der Rubrik "wissenstransfer". Wer noch nach einer Finanzierungsm{\"o}glichkeit f{\"u}r seine Promotion sucht, findet Tipps in der Rubrik "wegweiser". Die Redaktion w{\"u}nscht Ihnen viel Vergn{\"u}gen beim Lesen von Portal alumni und freut sich auf zahlreiche Leserbriefe.},
  language  = {de}
}