@misc{KossertZirrRichteretal.2011,
  author    = {Kossert, Thomas and Zirr, Alexander and Richter, Wenke and Sch{\"o}nauer, Tobias and Langer, Herbert and H{\"a}cker, Susanne and F{\"u}ssel, Marian and Asche, Matthias and Br{\"o}chler, Anja and Oldach, Robert and Kloosterhuis, J{\"u}rgen and Pr{\"o}ve, Ralf and Ludwig, Ulrike and Rischke, Janine and Theilig, Stephan},
  title     = {Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit = Themenheft: Universit{\"a}ten im Dreißigj{\"a}hrigen Krieg},
  volume    = {15},
  number    = {1},
  editor    = {Kossert, Thomas},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-152-3},
  issn      = {1617-9722},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-53892},
  year      = {2011},
  abstract  = {Die Geschichte der deutschen Universit{\"a}ten in der Zeit des Dreißigj{\"a}hrigen Krieges geh{\"o}rt traditionell nicht zu den bevorzugten Themen der historischen Forschung - weder der universit{\"a}ts-, noch der milit{\"a}rgeschichtlichen. Dieses ausgesprochene Desiderat hat spezifisch historiographiegeschichtliche Gr{\"u}nde und ist noch heute f{\"u}r viele Verzerrungen und Einseitigkeiten bei der Darstellung dieser f{\"u}r das deutsche Universit{\"a}tswesen durchaus z{\"a}surhaften Epoche verantwortlich. Die in diesem Heft pr{\"a}sentierten exemplarischen Studien gehen auf Vortr{\"a}ge eines Workshops des Arbeitskreises Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit auf Schloss Friedenstein in Gotha im Mai 2010 zur{\"u}ck und verstehen sich als eine erste Ann{\"a}herung an ein noch weithin offenes, aber keineswegs ausgesch{\"o}pftes Forschungsfeld.},
  language  = {de}
}
@article{DreymannWuenscheSabrowskietal.2022,
  author    = {Dreymann, Nico and Wuensche, Julia and Sabrowski, Wiebke and Moeller, Anja and Czepluch, Denise and Vu Van, Dana and F{\"u}ssel, Susanne and Menger, Marcus M.},
  title     = {Inhibition of Human Urokinase-Type Plasminogen Activator (uPA) Enzyme Activity and Receptor Binding by DNA Aptamers as Potential Therapeutics through Binding to the Different Forms of uPA},
  series = {International journal of molecular sciences},
  volume    = {23},
  journal   = {International journal of molecular sciences},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1661-6596},
  doi       = {10.3390/ijms23094890},
  pages     = {22},
  year      = {2022},
  abstract  = {Urokinase-type plasminogen activator is widely discussed as a marker for cancer prognosis and diagnosis and as a target for cancer therapies. Together with its receptor, uPA plays an important role in tumorigenesis, tumor progression and metastasis. In the present study, systematic evolution of ligands by exponential enrichment (SELEX) was used to select single-stranded DNA aptamers targeting different forms of human uPA. Selected aptamers allowed the distinction between HMW-uPA and LMW-uPA, and therefore, presumably, have different binding regions. Here, uPAapt-02-FR showed highly affine binding with a K-D of 0.7 nM for HMW-uPA and 21 nM for LMW-uPA and was also able to bind to pro-uPA with a K-D of 14 nM. Furthermore, no cross-reactivity to mouse uPA or tissue-type plasminogen activator (tPA) was measured, demonstrating high specificity. Suppression of the catalytic activity of uPA and inhibition of uPAR-binding could be demonstrated through binding with different aptamers and several of their truncated variants. Since RNA aptamers are already known to inhibit uPA-uPAR binding and other pathological functions of the uPA system, these aptamers represent a novel, promising tool not only for detection of uPA but also for interfering with the pathological functions of the uPA system by additionally inhibiting uPA activity.},
  language  = {en}
}