@article{HesseKlierSgarzietal.2018, author = {Hesse, Julia and Klier, Dennis Tobias and Sgarzi, Massimo and Nsubuga, Anne and Bauer, Christoph and Grenzer, Joerg and H{\"u}bner, Rene and Wislicenus, Marcus and Joshi, Tanmaya and Kumke, Michael Uwe and Stephan, Holger}, title = {Rapid Synthesis of Sub-10nm Hexagonal NaYF4-Based Upconverting Nanoparticles using Therminol((R))66}, series = {ChemistryOpen : including thesis treasury}, volume = {7}, journal = {ChemistryOpen : including thesis treasury}, number = {2}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {2191-1363}, doi = {10.1002/open.201700186}, pages = {159 -- 168}, year = {2018}, abstract = {We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.}, language = {en} } @article{HoffmannWirthBessleretal.2017, author = {Hoffmann, Mathias and Wirth, Stephan J. and Bessler, Holger and Engels, Christof and Jochheim, Hubert and Sommer, Michael and Augustin, J{\"u}rgen}, title = {Combining a root exclusion technique with continuous chamber and porous tube measurements for a pin-point separation of ecosystem respiration in croplands}, series = {Journal of plant nutrition and soil science = Zeitschrift f{\"u}r Pflanzenern{\"a}hrung und Bodenkunde}, volume = {181}, journal = {Journal of plant nutrition and soil science = Zeitschrift f{\"u}r Pflanzenern{\"a}hrung und Bodenkunde}, number = {1}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1436-8730}, doi = {10.1002/jpln.201600489}, pages = {41 -- 50}, year = {2017}, abstract = {To better assess ecosystem C budgets of croplands and understand their potential response to climate and management changes, detailed information on the mechanisms and environmental controls driving the individual C flux components are needed. This accounts in particular for the ecosystem respiration (R-eco) and its components, the autotrophic (R-a) and heterotrophic respiration (R-h) which vary tremendously in time and space. This study presents a method to separate R-eco into R-a [as the sum of R-a (shoot) and R-a (root)] and R-h in order to detect temporal and small-scale spatial dynamics within their relative contribution to overall R-eco. Thus, predominant environmental drivers and underlying mechanisms can be revealed. R-eco was derived during nighttime by automatic chamber CO2 flux measurements on plant covered plots. R-h was derived from CO2 efflux measurements, which were performed in parallel to R-eco measurements on a fallow plot using CO2 sampling tubes in 10 cm soil depth. R-a (root) was calculated as the difference between sampling tube CO2 efflux measurements on a plant covered plot and R-h. R-a (shoot) was calculated as R-eco - R-a (root) - R-h. Measurements were carried out for winter wheat (Triticum aestivum L.) during the crop season 2015 at an experimental plot located in the hummocky ground moraine landscape of NE Germany. R-eco varied seasonally from < 1 to 9.5 g C m(-2) d(-1), and was higher in adult (a) and reproductive (r) than juvenile (j) stands (gC m(-2) d(-1): j = 1.2, a = 4.6, r = 5.3). Observed R-a and R-h were in general smaller compared to the independently measured R-eco, contributing in average 58\% and 42\% to R-eco. However, both varied strongly regarding their environmental drivers and particular contribution throughout the study period, following the seasonal development of soil temperature and moisture (R-h) as well as crop development (R-a). Thus, our results consistently revealed temporal dynamics regarding the relative contribution of R-a (root) and R-a (shoot) to R-a, as well as of R-a and R-h to R-eco. Based on the observed results, implications for partitioning of R-eco in croplands are given.}, language = {en} } @book{GieseHildebrandtNeumannetal.2012, author = {Giese, Holger and Hildebrandt, Stephan and Neumann, Stefan and W{\"a}tzoldt, Sebastian}, title = {Industrial case study on the integration of SysML and AUTOSAR with triple graph grammars}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-191-2}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-60184}, publisher = {Universit{\"a}t Potsdam}, pages = {vi, 51}, year = {2012}, abstract = {During the overall development of complex engineering systems different modeling notations are employed. For example, in the domain of automotive systems system engineering models are employed quite early to capture the requirements and basic structuring of the entire system, while software engineering models are used later on to describe the concrete software architecture. Each model helps in addressing the specific design issue with appropriate notations and at a suitable level of abstraction. However, when we step forward from system design to the software design, the engineers have to ensure that all decisions captured in the system design model are correctly transferred to the software engineering model. Even worse, when changes occur later on in either model, today the consistency has to be reestablished in a cumbersome manual step. In this report, we present in an extended version of [Holger Giese, Stefan Neumann, and Stephan Hildebrandt. Model Synchronization at Work: Keeping SysML and AUTOSAR Models Consistent. In Gregor Engels, Claus Lewerentz, Wilhelm Sch{\"a}fer, Andy Sch{\"u}rr, and B. Westfechtel, editors, Graph Transformations and Model Driven Enginering - Essays Dedicated to Manfred Nagl on the Occasion of his 65th Birthday, volume 5765 of Lecture Notes in Computer Science, pages 555-579. Springer Berlin / Heidelberg, 2010.] how model synchronization and consistency rules can be applied to automate this task and ensure that the different models are kept consistent. We also introduce a general approach for model synchronization. Besides synchronization, the approach consists of tool adapters as well as consistency rules covering the overlap between the synchronized parts of a model and the rest. We present the model synchronization algorithm based on triple graph grammars in detail and further exemplify the general approach by means of a model synchronization solution between system engineering models in SysML and software engineering models in AUTOSAR which has been developed for an industrial partner. In the appendix as extension to [19] the meta-models and all TGG rules for the SysML to AUTOSAR model synchronization are documented.}, language = {en} } @book{GieseHildebrandtLambers2010, author = {Giese, Holger and Hildebrandt, Stephan and Lambers, Leen}, title = {Toward bridging the gap between formal semantics and implementation of triple graph grammars}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-078-6}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-45219}, publisher = {Universit{\"a}t Potsdam}, pages = {26}, year = {2010}, abstract = {The correctness of model transformations is a crucial element for the model-driven engineering of high quality software. A prerequisite to verify model transformations at the level of the model transformation specification is that an unambiguous formal semantics exists and that the employed implementation of the model transformation language adheres to this semantics. However, for existing relational model transformation approaches it is usually not really clear under which constraints particular implementations are really conform to the formal semantics. In this paper, we will bridge this gap for the formal semantics of triple graph grammars (TGG) and an existing efficient implementation. Whereas the formal semantics assumes backtracking and ignores non-determinism, practical implementations do not support backtracking, require rule sets that ensure determinism, and include further optimizations. Therefore, we capture how the considered TGG implementation realizes the transformation by means of operational rules, define required criteria and show conformance to the formal semantics if these criteria are fulfilled. We further outline how static analysis can be employed to guarantee these criteria.}, language = {en} } @book{GieseHildebrandt2009, author = {Giese, Holger and Hildebrandt, Stephan}, title = {Efficient model synchronization of large-scale models}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-940793-84-3}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-29281}, publisher = {Universit{\"a}t Potsdam}, pages = {27}, year = {2009}, abstract = {Model-driven software development requires techniques to consistently propagate modifications between different related models to realize its full potential. For large-scale models, efficiency is essential in this respect. In this paper, we present an improved model synchronization algorithm based on triple graph grammars that is highly efficient and, therefore, can also synchronize large-scale models sufficiently fast. We can show, that the overall algorithm has optimal complexity if it is dominating the rule matching and further present extensive measurements that show the efficiency of the presented model transformation and synchronization technique.}, language = {en} } @article{UhlemannGloeStephanetal.1994, author = {Uhlemann, Erhard and Gloe, Karsten and Stephan, Holger and Heitzsch, Olaf and Bukowsky, Heinz and Pollex, Rolf and Weber, Erwin}, title = {Preorganized endo-dicarboxylic host macrocycles having superior extraction selectivity for small alkaline earth metal ions}, year = {1994}, language = {en} } @article{GieseHildebrandtLambers2014, author = {Giese, Holger and Hildebrandt, Stephan and Lambers, Leen}, title = {Bridging the gap between formal semantics and implementation of triple graph grammars}, series = {Software and systems modeling}, volume = {13}, journal = {Software and systems modeling}, number = {1}, publisher = {Springer}, address = {Heidelberg}, issn = {1619-1366}, doi = {10.1007/s10270-012-0247-y}, pages = {273 -- 299}, year = {2014}, abstract = {The correctness of model transformations is a crucial element for model-driven engineering of high-quality software. A prerequisite to verify model transformations at the level of the model transformation specification is that an unambiguous formal semantics exists and that the implementation of the model transformation language adheres to this semantics. However, for existing relational model transformation approaches, it is usually not really clear under which constraints particular implementations really conform to the formal semantics. In this paper, we will bridge this gap for the formal semantics of triple graph grammars (TGG) and an existing efficient implementation. While the formal semantics assumes backtracking and ignores non-determinism, practical implementations do not support backtracking, require rule sets that ensure determinism, and include further optimizations. Therefore, we capture how the considered TGG implementation realizes the transformation by means of operational rules, define required criteria, and show conformance to the formal semantics if these criteria are fulfilled. We further outline how static and runtime checks can be employed to guarantee these criteria.}, language = {en} } @misc{HesseKlierSgarzietal.2018, author = {Hesse, Julia and Klier, Dennis Tobias and Sgarzi, Massimo and Nsubuga, Anne and Bauer, Christoph and Grenzer, J{\"o}rg and H{\"u}bner, Ren{\´e} and Wislicenus, Marcus and Joshi, Tanmaya and Kumke, Michael Uwe and Stephan, Holger}, title = {Rapid synthesis of sub-10 nm hexagonal NaYF4-based upconverting nanoparticles using Therminol® 66}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {613}, issn = {1866-8372}, doi = {10.25932/publishup-42351}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-423515}, pages = {10}, year = {2018}, abstract = {We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.}, language = {en} } @misc{PetersenFabianMeieretal.2012, author = {Petersen, Sven and Fabian, Steffi and Meier, Martin and Oldach, Robert and Giersch, Stephan and Gr{\"a}f, Holger and S{\"u}ß, Karsten}, title = {Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit}, volume = {16}, number = {2}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Arbeitskreis Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit e. V.}, issn = {1617-9722}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62068}, year = {2012}, abstract = {Der Arbeitskreis Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit e. V. wurde im Fr{\"u}hjahr 1995 gegr{\"u}ndet. Er hat es sich zur Aufgabe gemacht, die Erforschung des Milit{\"a}rs im Rahmen der fr{\"u}hneuzeitlichen Geschichte zu bef{\"o}rdern und zugleich das Bewusstsein der Fr{\"u}hneuzeit-HistorikerInnen f{\"u}r die Bedeutung des Milit{\"a}rs in all seinen Funktionen zu wecken. Das Milit{\"a}r steht somit als soziale Gruppe selbst im Mittelpunkt der Aktivit{\"a}ten des Arbeitskreises, wird aber auch in seinen Wirkungen und Repr{\"a}sentationen thematisiert. Ziel ist es, die Rolle des Milit{\"a}rs als Teil der fr{\"u}hneuzeitlichen Gesellschaft umfassend herauszuarbeiten und zu w{\"u}rdigen. Insofern versteht der AMG seine Arbeit nicht nur als Beitrag zur Milit{\"a}rgeschichte, sondern vor allem als Beitrag zur Geschichte der Fr{\"u}hen Neuzeit insgesamt. Der Arbeitskreis bietet ein Diskussions- und Informationsforum durch die Organisation von Tagungen, die Herausgabe der Schriftenreihe ‚Herrschaft und soziale Systeme in der Fr{\"u}hen Neuzeit', die Zeitschrift ‚Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit' und die Mailingliste mil-fnz.}, language = {de} } @article{GierschGraef2012, author = {Giersch, Stephan and Gr{\"a}f, Holger}, title = {Hessische Truppen im Amerikanischen Unabh{\"a}ngigkeitskrieg}, series = {Milit{\"a}r und Gesellschaft in der fr{\"u}hen Neuzeit}, volume = {16}, journal = {Milit{\"a}r und Gesellschaft in der fr{\"u}hen Neuzeit}, number = {2}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-9722}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-63765}, pages = {257 -- 263}, year = {2012}, language = {de} } @article{ScherberEisenhauerWeisseretal.2010, author = {Scherber, Christoph and Eisenhauer, Nico and Weisser, Wolfgang W. and Schmid, Bernhard and Voigt, Winfried and Fischer, Markus and Schukze, Ernst-Detlef and Roscher, Christiane and Weigelt, Alexandra and Allan, Eric and Beßler, Holger and Bonkowski, Michael and Buchmann, Nina and Buscot, Fran{\c{c}}ois and Clement, Lars W. and Ebeling, Anne and Engels, Christof and Halle, Stefan and Kertscher, Ilona and Klein, Alexandra-Maria and Koller, Robert and K{\"o}nig, Stephan and Kowalski, Esther and Kummer, Volker and Kuu, Annely and Lange, Markus and Lauterbach, Dirk}, title = {Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment}, issn = {0028-0836}, year = {2010}, language = {en} } @article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} }